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WNT16 Gene

protein-coding   GIFtS: 65
GCID: GC07P120965

Wingless-Type MMTV Integration Site Family, Member 16

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 161 2
Protein Wnt-162
Wingless-Type MMTV Integration Site Family Member 16b2

External Ids:    HGNC: 162671   Entrez Gene: 513842   Ensembl: ENSG000000027457   OMIM: 6062675   UniProtKB: Q9UBV43   

Export aliases for WNT16 gene to outside databases

Previous GC identifers: GC07P119443 GC07P120506 GC07P120519 GC07P120559 GC07P120752 GC07P115328


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT16 Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two
transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate
promoters and not to be splice variants from a single promoter. They are differentially expressed in normal
tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one
(variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and
spleen. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT16 Gene:
WNT16 (wingless-type MMTV integration site family, member 16) is a protein-coding gene. Diseases associated with WNT16 include osteoporotic fracture, and coffin-siris syndrome. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT16_HUMAN, Q9UBV4
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters (By similarity)

Gene Wiki entry for WNT16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT16 gene promoter:
         E2F-4   E2F-3a   AREB6   E2F   E2F-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): WNT16 promoter sequence
   Search Chromatin IP Primers for WNT16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.31   HGNC cytogenetic band: 7q31

WNT16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT16 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P120965:  view genomic region     (about GC identifiers)

Start:
120,965,421 bp from pter      End:
120,981,158 bp from pter
Size:
15,738 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 120,360,161-120,375,904     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WNT16_HUMAN, Q9UBV4 (See protein sequence)
Recommended Name: Protein Wnt-16 precursor  
Size: 365 amino acids; 40690 Da
Secondary accessions: Q2M3G1 Q9Y5C0
Alternative splicing: 2 isoforms:  Q9UBV4-1   Q9UBV4-2   

Explore the universe of human proteins at neXtProt for WNT16: NX_Q9UBV4

Explore proteomics data for WNT16 at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-227 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-81. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)1
  • Glycosylation2 at Asn143, Asn189, Asn311
  • Modification sites at PhosphoSitePlus

  • See WNT16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_057171.2  NP_476509.1  

    ENSEMBL proteins: 
     ENSP00000355065   ENSP00000222462  
    Reactome Protein details: Q9UBV4

    WNT16 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for WNT16
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    Novus Biologicals WNT16 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT16

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    WNT16 Assay Products:

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    Cloud-Clone Corp. ELISAs for WNT16
    Cloud-Clone Corp. CLIAs for WNT16


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR013304 Wnt16
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q9UBV4

    ProtoNet protein and cluster: Q9UBV4

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT16_HUMAN, Q9UBV4
    Similarity: Belongs to the Wnt family


    WNT16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT16_HUMAN, Q9UBV4
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
         
    WNT16 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Wnt16):
     skeleton 

    WNT16 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT16
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WNT16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WNT16

    miRNA
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    miRTarBase miRNAs that target WNT16:
    hsa-mir-181a-5p (MIRT025130)

    Block miRNA regulation of human, mouse, rat WNT16 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate WNT16:
    hsa-miR-548a-3p hsa-miR-520d-5p hsa-miR-374b hsa-miR-548e hsa-miR-524-5p hsa-miR-374a hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidWNT16 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WNT16
    Predesigned siRNA for gene silencing in human, mouse, rat WNT16

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WNT16 (NM_057168)
    Sino Biological Human cDNA Clone for WNT16
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT16

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for WNT16 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WNT16_HUMAN, Q9UBV4: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytosol1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA10500199
    GO:0005737cytoplasm IDA17200136

    WNT16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT16 About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    2Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    3Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT16 (see all 6)
        GSK3 Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency
    WNT Signaling

    1 Tocris Bioscience Pathway for WNT16
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT16
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for WNT16
        Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency

    2 Sino Biological Pathways for WNT16
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    2 Reactome Pathways for WNT16
        WNT ligand biogenesis and trafficking
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT16) (see all 9):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT16 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT16: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT16 (Q9UBV43 ENSP000002224624) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    FZD10ENSP000002290304STRING: ENSP00000229030
    FZD2ENSP000003239014STRING: ENSP00000323901
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003408optic cup formation involved in camera-type eye development ISS16258938
    GO:0007275multicellular organismal development ----
    GO:0010628positive regulation of gene expression IMP16007226
    GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling IMP19951988
    GO:0016055Wnt signaling pathway IBA--

    WNT16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT16



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WNT16 gene (2 alternative transcripts): 
    NM_016087.2  NM_057168.1  

    Unigene Cluster for WNT16:

    Wingless-type MMTV integration site family, member 16
    Hs.272375  [show with all ESTs]
    Unigene Representative Sequence: NM_057168
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361301 ENST00000222462(uc003vjv.3 uc003vjw.3 uc010lkl.3)

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate WNT16:
    hsa-miR-548a-3p hsa-miR-520d-5p hsa-miR-374b hsa-miR-548e hsa-miR-524-5p hsa-miR-374a hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidWNT16 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WNT16
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    GenScript: all cDNA clones in your preferred vector (see all 2): WNT16 (NM_057168)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT16
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for WNT16
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT16
      QuantiTect SYBR Green Assays in human, mouse, rat WNT16
      QuantiFast Probe-based Assays in human, mouse, rat WNT16

    Additional mRNA sequence: 

    AF152584.1 AF169963.1 BC104919.1 BC104945.1 EU190890.1 

    2 DOTS entries:

    DT.91714133  DT.91714131 

    9 AceView cDNA sequences:

    NM_057168 BM687236 NM_016087 AF169963 BU727592 AF152584 AA757499 BG698997 
    BF360293 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAATGTCT
    WNT16 Expression
    About this image


    WNT16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Epithelial Cells
             Intermediate Keratinocytes Embryonic Epidermis
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Intermediate Keratinocytes Embryonic Epidermis
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Hair
             Basal Keratinocytes Embryonic Epidermis
    WNT16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272375

    UniProtKB/Swiss-Prot: WNT16_HUMAN, Q9UBV4
    Tissue specificity: Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph
    nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT16: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for WNT16
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    QuantiFast Probe-based Assays in human, mouse, rat WNT16
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WNT16 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt161 , 5 wingless-related MMTV integration site 161, 5 88(n)1
    90.93(a)1
      6 (9.22 cM)5
    937351  NM_053116.41  NP_444346.31 
     222882275 
    chicken
    (Gallus gallus)
    Aves WNT161 wingless-type MMTV integration site family, member more 78.6(n)
    85.99(a)
      427856  XM_001233677.3  XP_001233678.3 
    lizard
    (Anolis carolinensis)
    Reptilia WNT166
    wingless-type MMTV integration site family, member...
    80(a)
    1 ↔ 1
    5(68819099-68824696)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wnt161 wingless-type MMTV integration site family, member more 73.08(n)
    76.92(a)
      100125197  NM_001103081.1  NP_001096551.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt161 wingless-type MMTV integration site family, member more 64.86(n)
    68.29(a)
      791563  NM_001100046.1  NP_001093516.1 
    worm
    (Caenorhabditis elegans)
    Secernentea egl-201 , 3 WNT protein3
    egl-201
    41(a)
    (best of 3)3
    50.96(n)1
    43.63(a)1
      IV(9813360-9815698)3
    1778211  NM_069353.51  NP_501754.11 


    ENSEMBL Gene Tree for WNT16 (if available)
    TreeFam Gene Tree for WNT16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT16 gene
    WNT5B2  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  WNT12  
    WNT42  WNT7A2  WNT7B2  WNT32  
    16 SIMAP similar genes for WNT16 using alignment to 6 protein entries:     WNT16_HUMAN (see all proteins):
    WNT4    WNT2B    WNT7A    WNT1    WNT11    WNT7B
    WNT3A    WNT8A    WNT3    WNT5A    WNT2    WNT9A
    WNT8B    WNT9B    WNT5B    WNT6

    WNT16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WNT16 (see all 396)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362894
    A colorectal cancer sample4--see VAR_0362892 V M mis40--------
    rs720323351,2
    C--120374272(+) GGACC-/CTCT  
            
    TGAGA
    2 -- ut310--------
    rs106328841,2
    C--120374273(+) GACCT-/CTCT  
            
    GAGAG
    2 -- ut310--------
    rs711702461,2
    C--120376404(-) GTCTT-/AAAAAAA 2 -- ds50011Minor allele frequency- AA:0.00NA 2
    rs571149261,2
    C--120965187(+) CGCGC-/GCGC/ 
    GCGCGCAC
    ACACA
    1 -- us2k11NA 2
    rs557106881,2
    C--120965466(+) ACCCA-/CCCA  
            
    TGCAG
    1 -- ut510--------
    rs562191251,2
    C--120972291(+) TATAC-/GTGTGTG 2 -- int10--------
    rs362246141,2
    C--120976041(+) AACTT-/TGTG  
      TGTGTG
    TGTGT
    2 -- int10--------
    rs1404098561,2
    --124312283(+) CTACTA/GACACT 1 -- us2k10--------
    rs1503711761,2
    --124312354(+) TGGTTA/GTGGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT16 (120965421 - 120981158 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WNT16:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269393CNV Insertion20981092
    dgv2132e1CNV Complex17122850
    nsv7405OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): WNT16
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT16
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606267    OMIM disorders: --

    11 diseases for WNT16:    
    About MalaCards
    osteoporotic fracture    coffin-siris syndrome    basal cell carcinoma    breast and colorectal cancer
    lymphoblastic leukemia    chronic lymphocytic leukemia    colorectal cancer    leukemia
    prostate cancer    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for WNT16:
    Coffin-Siris syndrome

    WNT16 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WNT16
    Human Genome Epidemiology (HuGE) Navigator: WNT16 (1 document)

    Export disorders for WNT16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT16 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with WNT16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. (PubMed id 10500199)1, 2, 3 McWhirter J.R.... Murre C. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues. (PubMed id 11095990)1, 2, 9 Fear M.W.... Barnes M.R. (Biochem. Biophys. Res. Commun. 2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line. (PubMed id 16769578)1, 9 Casagrande G.... Basso G. (Haematologica 2006)
    6. Missense polymorphisms of the WNT16 gene are associated with bone mass, hip geometry and fractures. (PubMed id 23417354)1 GarcA-a-Ibarbia C....Riancho J.A. (Osteoporos Int 2013)
    7. Paracrine activation of WNT/I^-catenin pathway in uterine leiomyoma stem cells promotes tumor growth. (PubMed id 24082114)1 Ono M....Bulun S.E. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    8. Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women. (PubMed id 23074152)1 Koller D.L....Foroud T. (J. Bone Miner. Res. 2013)
    9. Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2. (PubMed id 23617586)1 Howard E.W....Sanghera D.K. (BMC Genet. 2013)
    10. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PubMed id 22504420)1 Estrada K....Rivadeneira F. (Nat. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 51384 HGNC: 16267 AceView: WNT16 Ensembl:ENSG00000002745 euGenes: HUgn51384
    ECgene: WNT16 Kegg: 51384 H-InvDB: WNT16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WNT16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT16 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for WNT16 gene:
    Search GeneIP for patents involving WNT16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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