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WNT11 Gene

protein-coding   GIFtS: 64
GCID: GC11M075897

Wingless-Type MMTV Integration Site Family, Member 11

  See WNT11-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 111 2
HWNT112
Protein Wnt-112

External Ids:    HGNC: 127761   Entrez Gene: 74812   Ensembl: ENSG000000857417   OMIM: 6036995   UniProtKB: O960143   

Export aliases for WNT11 gene to outside databases

Previous GC identifers: GC11M078224 GC11M077436 GC11M076120 GC11M075623 GC11M075575 GC11M072194


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT11 Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein
which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively.
This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible
candidate gene for High Bone Mass Syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT11 Gene:
WNT11 (wingless-type MMTV integration site family, member 11) is a protein-coding gene. Diseases associated with WNT11 include mass syndrome. GO annotations related to this gene include Ras GTPase activator activity and transcription regulatory region DNA binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT11_HUMAN, O96014
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters

Gene Wiki entry for WNT11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT11 gene promoter:
         CREB   Spz1   Nkx2-2   deltaCREB   HNF-4alpha2   ATF   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT11 promoter sequence
   Search Chromatin IP Primers for WNT11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13.5

WNT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT11 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M075897:  view genomic region     (about GC identifiers)

Start:
75,897,369 bp from pter      End:
75,921,780 bp from pter
Size:
24,412 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WNT11_HUMAN, O96014 (See protein sequence)
Recommended Name: Protein Wnt-11 precursor  
Size: 354 amino acids; 39179 Da
Secondary accessions: B2R8Z6 Q14DE8 Q8WZ98

Explore the universe of human proteins at neXtProt for WNT11: NX_O96014

Explore proteomics data for WNT11 at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-80. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)1
  • Glycosylation2 at Asn40, Asn90, Asn160, Asn300, Asn304
  • Modification sites at PhosphoSitePlus

  • See WNT11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004617.2  
    ENSEMBL proteins: 
     ENSP00000325526   ENSP00000436140  
    Reactome Protein details: O96014

    WNT11 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for WNT11

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR026536 Wnt-11
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry O96014

    ProtoNet protein and cluster: O96014

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT11_HUMAN, O96014
    Similarity: Belongs to the Wnt family


    Find genes that share domains with WNT11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT11_HUMAN, O96014
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters

         Genatlas biochemistry entry for WNT11:
    wingless-type MMTV integration site 11,Drosophila wingless (Wg) segment polarity gene homolog,modulating cell fate
    and cell behavior during vertebrate development,expressed in the perichondrium of the developing skeleton

         Summary: 
    During embryonic development, WNT11 as signaling molecule is secreted from the following cells:
                fully expand
    Somite: Dermal Progenitor Cells (Cervical Central Dermomyotome), Dermal Progenitor Cells (Sacral Central Dermomyotome)      fully expand to see all 8 cells

    It affects the following cells:
    Heart: Cardiomyocyte Progenitor Cells (Myocardium), Cardiomyocytes (Outflow Tract)       to see all 2 cells
    Dermis: Dermal Mesenchyme Cells (Dorsal Subectodermal Mesenchyme)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005099Ras GTPase activator activity IMP--
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
    GO:0005515protein binding ----
    GO:0030295protein kinase activator activity IMP--
         
    Find genes that share ontologies with WNT11           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Wnt11):
     cardiovascular system  craniofacial  digestive/alimentary  mortality/aging  renal/urinary system 
     reproductive system 

    Find genes that share phenotypes with WNT11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wnt11tm1Amc for WNT11

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT11
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    hsa-miR-142-5p hsa-miR-4311 hsa-miR-4307 hsa-miR-485-3p hsa-miR-410 hsa-miR-340 hsa-miR-583 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidWNT11 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WNT11_HUMAN, O96014: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytoskeleton1
    lysosome1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--
    GO:0005737cytoplasm IDA--
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with WNT11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT11 About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    3beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    4Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    5Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43


    Find genes that share SuperPaths with WNT11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT11
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT11 (see all 7)
        Factors Promoting Cardiogenesis in Vertebrates
    GSK3 Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT11
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT11
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for WNT11
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)

    2 Sino Biological Pathways for WNT11
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    4 Reactome Pathways for WNT11
        PCP/CE pathway
    Ca2+ pathway
    WNT ligand biogenesis and trafficking
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT11) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT11: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT11 (O960142, 3 ENSP000003255264) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RSPO2Q6UXX93, ENSP000002766594I2D: score=1 STRING: ENSP00000276659
    TCF4P158843, ENSP000003464404I2D: score=1 STRING: ENSP00000346440
    WIF1Q9Y5W52, ENSP000002865744MINT-8389852 STRING: ENSP00000286574
    TDGF1P133853I2D: score=1 
    CER1ENSP000003702974STRING: ENSP00000370297
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 44):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation IEA--
    GO:0001822kidney development ----
    GO:0003151outflow tract morphogenesis IEA--
    GO:0006468protein phosphorylation IMP--
    GO:0007275multicellular organismal development ----

    Find genes that share ontologies with WNT11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT11

    2 Novoseek inferred chemical compound relationships for WNT11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 1 14766423 (1)
    tyrosine 0 1 19747829 (1)



    Find genes that share compounds with WNT11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WNT11 gene: 
    NM_004626.2  

    Unigene Cluster for WNT11:

    Wingless-type MMTV integration site family, member 11
    Hs.108219  [show with all ESTs]
    Unigene Representative Sequence: Y12692
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322563(uc001oxe.3 uc001oxf.1) ENST00000529461 ENST00000532150

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    hsa-miR-142-5p hsa-miR-4311 hsa-miR-4307 hsa-miR-485-3p hsa-miR-410 hsa-miR-340 hsa-miR-583 hsa-miR-3916
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    Additional mRNA sequence: 

    AB070218.1 AK075540.1 AK313570.1 BC074790.2 BC074791.2 BC113386.1 BC113388.1 BT019492.1 
    JF800675.1 Y12692.1 

    5 DOTS entries:

    DT.86821050  DT.75151395  DT.70104352  DT.99992523  DT.91753316 

    Selected AceView cDNA sequences (see all 60):

    AI767621 AI733704 NM_004626 BX109552 AI792427 AI371117 AK075540 BM851756 
    AI185936 CD514430 AW009544 AI139665 AA360026 AA033748 AW160642 BC074791 
    BC074790 AI193684 BV188045 AW161238 AW161773 AI733706 AI919282 BF194789 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATCACTAG
    WNT11 Expression
    About this image


    WNT11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 16 entries
             Dermal Mesenchyme Cells Dorsal Subectodermal Mesenchyme
     
     Somite (Muscoskeletal System)    fully expand to see all 8 entries
             Dermal Progenitor Cells Sacral Dorsomedial Dermomyotome Lip
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Kidney (Urinary System)    fully expand to see all 6 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
             mK3
             Renal progenitor cells (Urteric bud-like cells)
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Dermal Progenitor Cells Somatopleure
    WNT11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.108219

    UniProtKB/Swiss-Prot: WNT11_HUMAN, O96014
    Tissue specificity: Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT11: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Notch Signaling Pathway in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for WNT11 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt111 , 5 wingless-related MMTV integration site 111, 5 92.37(n)1
    97.46(a)1
      7 (53.90 cM)5
    224111  NM_009519.21  NP_033545.11 
     988351125 
    chicken
    (Gallus gallus)
    Aves WNT111 wingless-type MMTV integration site family, member more 77.68(n)
    85.03(a)
      395562  NM_204784.1  NP_990115.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT116
    wingless-type MMTV integration site family, member...
    86(a)
    1 ↔ 1
    GL343298.1(1595644-1666675)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.10732 Xenopus laevis maternal protein (wnt-11) mRNA, complete more 78.05(n)    L23542.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt11r2 wnt11-related 75.65(n)   30283  AF249266.1 


    ENSEMBL Gene Tree for WNT11 (if available)
    TreeFam Gene Tree for WNT11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT11 gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT22  WNT2B2  WNT3A2  WNT12  
    WNT42  WNT7A2  WNT7B2  WNT32  
    17 SIMAP similar genes for WNT11 using alignment to 1 protein entry:     WNT11_HUMAN:
    WNT4    WNT2    WNT3    WNT16    WNT2B    WNT3A
    WNT7B    WNT5A    WNT5B    WNT1    WNT7A    WNT6
    WNT8B    WNT8A    WNT9A    WNT9B    WNT10B

    Find genes that share paralogs with WNT11           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for WNT11
    PGOHUM00000250384


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WNT11 (see all 503)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156715021,2
    Cuntested175914444(+) GGGGGA/C/TGGCCT 1 -- int10--------
    rs758464161,2
    F--75896880(+) CCCACA/CTGCAA 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs1844410321,2
    --75897041(+) CTGCAA/GCTGGC 1 -- ds50010--------
    rs1408427751,2
    --75897069(+) GTCACA/GCAGAA 1 -- ds50010--------
    rs1447523671,2
    --75897266(+) CAAGAC/TGTCTG 1 -- ds50010--------
    rs1885332881,2
    --75897337(+) AGCGCA/GGGGGG 1 -- ds50010--------
    rs177492021,2
    C,F,H--75897374(+) TTGCCT/CGGAAA 1 -- ut31 ese316Minor allele frequency- C:0.20NA NS EA WA 1226
    rs49450441,2
    H--75897610(+) TATTTC/GTGTAG 1 -- ut31 ese34Minor allele frequency- G:0.00NS EA 420
    rs1918516301,2
    --75897726(+) GCCAGA/GGGGTC 1 -- ut310--------
    rs1512971661,2
    --75897733(+) GGTCCC/TGCAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for WNT11 (75897369 - 75921780 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WNT11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897926CNV Loss21882294
    nsv897927CNV Loss21882294
    nsv897928CNV Loss21882294
    nsv897929CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT11
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603699    OMIM disorders: --

    1 disease for WNT11:    
    About MalaCards
    mass syndrome


    Find genes that share disorders with WNT11           About GenesLikeMe

    2 Novoseek inferred disease relationships for WNT11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 15.6 2 11712081 (1), 19578797 (1)
    tumors 0 2 20103596 (2)

    Genetic Association Database (GAD): WNT11
    Human Genome Epidemiology (HuGE) Navigator: WNT11 (8 documents)

    Export disorders for WNT11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT11 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with WNT11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. (PubMed id 9757009)1, 2, 3 Lako M.... Lindsay S. (Gene 1998)
    2. Molecular cloning and characterization of human WNT11. (PubMed id 11712081)1, 2, 9 Kirikoshi H.... Katoh M. (Int. J. Mol. Med. 2001)
    3. Genome-wide association study of PR interval. (PubMed id 20062060)1, 4 Pfeufer A....Heckbert S.R. (Nat. Genet. 2010)
    4. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PubMed id 20890934)1, 4 Menezes R....Vieira A.R. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    8. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PubMed id 18413325)1, 4 Chiquet B.T....Hecht J.T. (Hum. Mol. Genet. 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells. (PubMed id 20219091)1, 9 Uysal-Onganer P....Kypta R.M. (Mol. Cancer 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7481 HGNC: 12776 AceView: WNT11 Ensembl:ENSG00000085741 euGenes: HUgn7481
    ECgene: WNT11 Kegg: 7481 H-InvDB: WNT11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WNT11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT11 gene:
    Search GeneIP for patents involving WNT11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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