Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WNT11 Gene

Aliases for WNT11 Gene

  • Wingless-Type MMTV Integration Site Family, Member 11 2 3
  • Protein Wnt-11 3
  • HWNT11 3

External Ids for WNT11 Gene

Summaries for WNT11 Gene

Entrez Gene Summary for WNT11 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT11 Gene

WNT11 (Wingless-Type MMTV Integration Site Family, Member 11) is a Protein Coding gene. Diseases associated with WNT11 include mass syndrome. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include transcription regulatory region DNA binding. An important paralog of this gene is WNT1.

UniProtKB/Swiss-Prot for WNT11 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters

Gene Wiki entry for WNT11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT11 Gene

Genomics for WNT11 Gene

Genomic Location for WNT11 Gene

Start:
76,186,325 bp from pter
End:
76,210,759 bp from pter
Size:
24,435 bases
Orientation:
Minus strand

Genomic View for WNT11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT11 Gene

Regulatory Elements for WNT11 Gene

Proteins for WNT11 Gene

  • Protein details for WNT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96014-WNT11_HUMAN
    Recommended name:
    Protein Wnt-11
    Protein Accession:
    O96014
    Secondary Accessions:
    • B2R8Z6
    • Q14DE8
    • Q8WZ98

    Protein attributes for WNT11 Gene

    Size:
    354 amino acids
    Molecular mass:
    39179 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WNT11 Gene

Proteomics data for WNT11 Gene at MOPED

Post-translational modifications for WNT11 Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn40, Asn90, Asn160, Asn300, and Asn304

Other Protein References for WNT11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT11 Gene

Domains for WNT11 Gene

Gene Families for WNT11 Gene

HGNC:
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT11 Gene

UniProtKB/Swiss-Prot:

WNT11_HUMAN
Family:
  • Belongs to the Wnt family.:
    • O96014
genes like me logo Genes that share domains with WNT11: view

Function for WNT11 Gene

Molecular function for WNT11 Gene

GENATLAS Biochemistry: wingless-type MMTV integration site 11,Drosophila wingless (Wg) segment polarity gene homolog,modulating cell fate and cell behavior during vertebrate development,expressed in the perichondrium of the developing skeleton
UniProtKB/Swiss-Prot Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters

Gene Ontology (GO) - Molecular Function for WNT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IMP 20103596
GO:0005102 receptor binding --
GO:0005109 frizzled binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0030295 protein kinase activator activity IMP 20103596
genes like me logo Genes that share ontologies with WNT11: view
genes like me logo Genes that share phenotypes with WNT11: view

Animal Models for WNT11 Gene

MGI Knock Outs for WNT11:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for WNT11 Gene

Localization for WNT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT11 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT11 Gene COMPARTMENTS Subcellular localization image for WNT11 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WNT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IDA 20103596
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with WNT11: view

Pathways for WNT11 Gene

genes like me logo Genes that share pathways with WNT11: view

Gene Ontology (GO) - Biological Process for WNT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0001822 kidney development --
GO:0003151 outflow tract morphogenesis IEA --
GO:0006468 protein phosphorylation IMP 20103596
GO:0007275 multicellular organismal development --
genes like me logo Genes that share ontologies with WNT11: view

Compounds for WNT11 Gene

(2) Novoseek inferred chemical compound relationships for WNT11 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 1
tyrosine 0 1
genes like me logo Genes that share compounds with WNT11: view

Transcripts for WNT11 Gene

Unigene Clusters for WNT11 Gene

Wingless-type MMTV integration site family, member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WNT11 Gene

No ASD Table

Relevant External Links for WNT11 Gene

GeneLoc Exon Structure for
WNT11
ECgene alternative splicing isoforms for
WNT11

Expression for WNT11 Gene

mRNA expression in normal human tissues for WNT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT11 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (6.5) and Adipose - Subcutaneous (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WNT11 Gene

SOURCE GeneReport for Unigene cluster for WNT11 Gene Hs.108219

mRNA Expression by UniProt/SwissProt for WNT11 Gene

O96014-WNT11_HUMAN
Tissue specificity: Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.
genes like me logo Genes that share expressions with WNT11: view

Orthologs for WNT11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WNT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT11 36
  • 99.91 (n)
  • 100 (a)
WNT11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT11 36
  • 94.44 (n)
  • 97.74 (a)
WNT11 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT11 36
  • 94.16 (n)
  • 98.59 (a)
WNT11 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt11 36
  • 92.37 (n)
  • 97.46 (a)
Wnt11 16
Wnt11 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT11 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT11 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt11 36
  • 92 (n)
  • 97.46 (a)
chicken
(Gallus gallus)
Aves WNT11 36
  • 77.68 (n)
  • 85.03 (a)
WNT11 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT11 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1073 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3082 36
wnt11r 36
  • 74.78 (n)
  • 80.29 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8886 36
zebrafish
(Danio rerio)
Actinopterygii wnt11r 36
  • 73.14 (n)
  • 78.24 (a)
wnt11r 37
  • 76 (a)
OneToOne
Species with no ortholog for WNT11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WNT11 Gene

ENSEMBL:
Gene Tree for WNT11 (if available)
TreeFam:
Gene Tree for WNT11 (if available)

Paralogs for WNT11 Gene

Paralogs for WNT11 Gene

Selected SIMAP similar genes for WNT11 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for WNT11 Gene

genes like me logo Genes that share paralogs with WNT11: view

Variants for WNT11 Gene

Sequence variations from dbSNP and Humsavar for WNT11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs94111 -- 76,204,095(+) ACGGC(A/G)CCTAG intron-variant
rs596339 -- 76,205,463(-) TTCCG(A/G)GGCTG intron-variant
rs608747 -- 76,205,433(+) CTCCC(A/G)GCAGC intron-variant
rs655814 -- 76,202,734(+) AGAAG(C/T)CCCTG intron-variant
rs663907 -- 76,212,025(+) GTGAG(C/T)TTCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WNT11 Gene

Variant ID Type Subtype PubMed ID
nsv897926 CNV Loss 21882294
nsv897927 CNV Loss 21882294
nsv897928 CNV Loss 21882294
nsv897929 CNV Loss 21882294

Relevant External Links for WNT11 Gene

HapMap Linkage Disequilibrium report
WNT11

Disorders for WNT11 Gene

(1) MalaCards Diseases for WNT11 Gene

Search for WNT11 Gene in MalaCards »

(2) Novoseek inferred disease relationships for WNT11 Gene

Disease -log(P) Hits PubMed IDs
gastric cancer 15.6 2
tumors 0 2

Relevant External Links for WNT11

Genetic Association Database (GAD)
WNT11
Human Genome Epidemiology (HuGE) Navigator
WNT11
genes like me logo Genes that share disorders with WNT11: view

No data available for UniProtKB/Swiss-Prot for WNT11 Gene

Publications for WNT11 Gene

  1. Molecular cloning and characterization of human WNT11. (PMID: 11712081) Kirikoshi H. … Katoh M. (Int. J. Mol. Med. 2001) 3 4 23
  2. Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. (PMID: 9757009) Lako M. … Lindsay S. (Gene 1998) 2 3 4
  3. Notch signaling contributes to the expression of cardiac markers in human circulating progenitor cells. (PMID: 17967789) Koyanagi M. … Dimmeler S. (Circ. Res. 2007) 3 23
  4. Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration. (PMID: 20103596) Toyama T. … Kim M. (Mol. Cancer Res. 2010) 3 23
  5. Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells. (PMID: 20219091) Uysal-Onganer P. … Kypta R.M. (Mol. Cancer 2010) 3 23

Products for WNT11 Gene

Sources for WNT11 Gene

Back to Top

Content