Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WNT11 Gene

protein-coding GIFtS: 63
GCID: GC11M075897

wingless-type MMTV integration site family, member 11

Explore 21 diseases affiliated with
WNT11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 11¹ ²
HWNT11²
Protein Wnt-11²

External Ids:	HGNC: 12776¹	Entrez Gene: 7481²	Ensembl: ENSG00000085741⁷	OMIM: 603699⁵	UniProtKB: O96014³

Export aliases for WNT11 gene to outside databases

Previous GC identifers: GC11M078224 GC11M077436 GC11M076120 GC11M075623 GC11M075575 GC11M072194

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT11:

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins

have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and

patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%,

85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play

roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High

Bone Mass Syndrome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT11_HUMAN, O96014

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over

only few cell diameters

Gene Wiki entry for WNT11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WNT11 gene promoter:
CREB Spz1 Nkx2-2 deltaCREB HNF-4alpha2 ATF HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT11 promoter sequence

Search SABiosciences Chromatin IP Primers for WNT11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q13.5

WNT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT11 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M075897: view genomic region (about GC identifiers)

Start:	75,897,369 bp from pter	End:	75,921,803 bp from pter
Size:	24,435 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WNT11_HUMAN, O96014 (See protein sequence)

Recommended Name: Protein Wnt-11 precursor

Size: 354 amino acids; 39179 Da

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: B2R8Z6 Q14DE8 Q8WZ98

Explore the universe of human proteins at neXtProt for WNT11: NX_O96014

Post-translational modifications:

Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. It is also required for subsequent

palmitoylation at Cys-80. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O96014

WNT11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004617.2

ENSEMBL proteins:

ENSP00000325526 ENSP00000431755 ENSP00000436140

Reactome Protein details: O96014
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for WNT11 (Wnt-11)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: WNT11 OriGene Custom Protein Services for WNT11
	GenScript Custom Purified and Recombinant Proteins Services for WNT11
	Novus Biologicals WNT11 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for WNT11

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IBA	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IBA	--

WNT11 for ontologies About GeneDecksing

WNT11 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for WNT11 (Wnt-11)
	OriGene Antibodies: WNT11 OriGene Custom Antibody Services for WNT11
	GenScript Custom Superior Antibodies Services for WNT11
	Novus Biologicals WNT11 Antibodies
	Abcam antibodies for WNT11
	Uscn Antibodies for WNT11
	ThermoFisher Antibody for WNT11

Assay Products for WNT11:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for WNT11
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for WNT11

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WNT11 for domains About GeneDecksing

3 InterPro domains/families:

IPR005817 Wnt

IPR026536 Wnt-11

IPR018161 Wnt_CS

Graphical View of Domain Structure for InterPro Entry O96014

ProtoNet protein and cluster: O96014

1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

UniProtKB/Swiss-Prot: WNT11_HUMAN, O96014

Similarity: Belongs to the Wnt family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: WNT11_HUMAN, O96014

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over

only few cell diameters

Genatlas biochemistry entry for WNT11:

wingless-type MMTV integration site 11,Drosophila wingless (Wg) segment polarity gene homolog,modulating cell fate and

cell behavior during vertebrate development,expressed in the perichondrium of the developing skeleton

Summary:

During embryonic development, WNT11 as signaling molecule

affects the following cells: Cardiomyocytes in Outflow Tract, Cardiomyocytes Progenitor Cells in Myocardium

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT11
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT11 (see all 17):
		hsa-miR-142-5p hsa-miR-4311 hsa-miR-4307 hsa-miR-485-3p hsa-miR-410 hsa-miR-340 hsa-miR-583 hsa-miR-3916

		SwitchGear 3'UTR luciferase reporter plasmid: WNT11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT11 (see all 4) OriGene shRNA RFP: WNT11 OriGene siRNA: WNT11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT11

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for WNT11

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT11 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT11 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: WNT11 (NM_004626)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT11

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for WNT11
		Search LifeMap BioReagents cell lines for WNT11

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT11

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein coupled receptor binding	IBA	--
GO:0005099	Ras GTPase activator activity	IMP	--
GO:0005102	receptor binding	--	--
GO:0005515	protein binding	--	--
GO:0030295	protein kinase activator activity	IMP	--

WNT11 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Wnt11^tm1Amc for WNT11
     6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Wnt11):

cardiovascular system	craniofacial	digestive/alimentary	mortality/aging	renal/urinary system
reproductive system

WNT11 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt Signaling Pathway	0.33
Wnt Signaling Pathway and Pluripotency	0.55	Wnt signaling pathway	0.30
DNA damage response (only ATM dependent)	0.35

Basal cell carcinoma

	Basal cell carcinoma	1.00			Wnt Pathway	0.37
	Hedgehog signaling pathway	0.41			Melanogenesis	0.32

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for WNT11

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for WNT11

Wnt Signaling Pathway

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT11 (see all 7)

	Factors Promoting Cardiogenesis in Vertebrates
	GSK3 Signaling
	Colorectal Cancer Metastasis
	Human Embryonic Stem Cell Pluripotency
	Nanog in Mammalian ESC Pluripotency

1 Tocris Bioscience Pathway for WNT11

Wnt Pathway

2 GeneGo (Thomson Reuters) Pathways for WNT11

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

3 BioSystems Pathways for WNT11

	Wnt Signaling Pathway and Pluripotency
	Wnt Signaling Pathway
	DNA damage response (only ATM dependent)

4 Reactome Pathways for WNT11

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

5 Kegg Pathways (Kegg details for WNT11):

	Wnt signaling pathway
	Hedgehog signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

WNT11 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for WNT11

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/20 Interacting proteins for WNT11 (O96014^{2, 3} ENSP00000325526⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WIF1	Q9Y5W5², ENSP00000286574⁴	MINT-8389852 STRING: ENSP00000286574
RSPO2	Q6UXX9³	I2D: score=1
TCF4	P15884³	I2D: score=1
TDGF1	P13385³	I2D: score=1
CER1	ENSP00000370297⁴	STRING: ENSP00000370297

About this table

Gene Ontology (GO): 5/44 biological process terms (GO ID links to tree view) (see all 44): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001649	osteoblast differentiation	IBA	--
GO:0001822	kidney development	--	--
GO:0003151	outflow tract morphogenesis	IBA	--
GO:0006468	protein phosphorylation	IMP	--
GO:0007275	multicellular organismal development	--	--

WNT11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

WNT11 for compounds About GeneDecksing

EMD Millipore small molecules for WNT11:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WNT11
2 Novoseek chemical compound relationships for WNT11 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	0	1	14766423 (1)
tyrosine	0	1	19747829 (1)

Search CenterWatch for drugs/clinical trials and news about WNT11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WNT11 gene:

NM_004626.2

Unigene Cluster for WNT11:

Wingless-type MMTV integration site family, member 11

Hs.108219 [show with all ESTs]

Unigene Representative Sequence: Y12692

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000322563(uc001oxe.3 uc001oxf.1) ENST00000531317 ENST00000529461

ENST00000532150

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT11
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT11 (see all 17):
		hsa-miR-142-5p hsa-miR-4311 hsa-miR-4307 hsa-miR-485-3p hsa-miR-410 hsa-miR-340 hsa-miR-583 hsa-miR-3916

		SwitchGear 3'UTR luciferase reporter plasmid: WNT11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT11 (see all 4) OriGene shRNA RFP: WNT11 OriGene siRNA: WNT11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT11

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT11 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT11 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: WNT11 (NM_004626)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT11

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat WNT11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT11

Additional cDNA sequence:

AB070218.1 AK075540.1 AK313570.1 BC074790.2 BC074791.2 BC113386.1 BC113388.1 BT019492.1

JF800675.1 Y12692.1

5 DOTS entries:

DT.86821050 DT.75151395 DT.70104352 DT.99992523 DT.91753316

24/60 AceView cDNA sequences (see all 60):

BM851756 AI733704 BC074790 AW009544 AI185936 CD514430 NM_004626 AI792427

AA360026 AK075540 AI767621 BX109552 AW160642 AA033748 BC074791 AI371117

AI139665 AW161773 AW161238 AI378504 AB070218 BX357994 AI733706 Y12692

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WNT11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATCACTAG

About this image

WNT11 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Ureteric Bud Tip Cells

Kidney

Lateral Plate Mesoderm

Lateral Plate Mesoderm Cells

Mesoderm

Early Embryo

Cervical Dorsomedial Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Somite

Lumbar Dorsomedial Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Somite

Sacral Dorsomedial Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Somite

Thoracic Dorsomedial Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Kidney

Metanephros

Kidney

Ureteric Bud

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

mK3 (Cell line)

Kidney

mK4 (Cell line)

Kidney

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Renal progenitor cells (Urteric bud-like cells) (Stepwise renal linea...)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See WNT11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WNT11

SOURCE GeneReport for Unigene cluster: Hs.108219

UniProtKB/Swiss-Prot: WNT11_HUMAN, O96014

Tissue specificity: Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas

SABiosciences Expression via Pathway-Focused PCR Arrays including WNT11:

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Pathway in human mouse rat

Epithelial to Mesenchymal Transition (EMT) in human mouse rat

Notch Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat WNT11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT11

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for WNT11 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	WNT11¹	wingless-type MMTV integration site family, member more	77.68(n) 85.03(a)		395562 NM_204784.1 NP_990115.1
lizard (Anolis carolinensis)	Reptilia	WNT11⁶	--	83(a)	1 ↔ 1	GL343298.1(1599946-1621917)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1073²	Xenopus laevis maternal protein (wnt-11) mRNA, complete more	78.05(n)		L23542.1
zebrafish (Danio rerio)	Actinopterygii	wnt11r²	wnt11-related	75.65(n)		30283 AF249266.1
honey bee (Apis mellifera)	Insecta	--	--	39(a)	1 ↔ 1	GroupUn.149(18009-32364)
worm (Caenorhabditis elegans)	Secernentea	mom-2⁶	Protein mom-2	30(a)	1 → many	V(8355968-8358168)

ENSEMBL Gene Tree for WNT11 (if available)
TreeFam Gene Tree for WNT11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WNT11 gene

WNT5B² WNT16² WNT6² WNT5A² WNT2² WNT2B² WNT3A² WNT1²

WNT10B² WNT4² WNT7A² WNT7B² WNT10A² WNT3²

17 SIMAP similar genes for WNT11 using alignment to 2 protein entries: WNT11_HUMAN (see all proteins):

WNT4 WNT2 WNT3 WNT7B WNT16 WNT2B

WNT3A WNT5A WNT1 WNT7A WNT5B WNT6

WNT8B WNT8A WNT9A WNT9B WNT10B

WNT11 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for WNT11
PGOHUM00000250384

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115671502^1,2	C,	unknown	75914444(+)	`GGGGGA/C/TGGCCT`	1	--	int¹		0	--	--	--	--
rs75846416^1,2	F,	--	75896880(+)	`CCCACA/CTGCAA`	1	--	ds500¹		1		WA	118
rs184441032^1,2		--	75897041(+)	`CTGCAA/GCTGGC`	1	--	ds500¹		0	--	--	--	--
rs140842775^1,2		--	75897069(+)	`GTCACA/GCAGAA`	1	--	ds500¹		0	--	--	--	--
rs144752367^1,2		--	75897266(+)	`CAAGAC/TGTCTG`	1	--	ds500¹		0	--	--	--	--
rs188533288^1,2		--	75897337(+)	`AGCGCA/GGGGGG`	1	--	ds500¹		0	--	--	--	--
rs17749202^1,2	C,F,H,	--	75897374(+)	`TTGCCT/CGGAAA`	1	--	ut3¹ ese³		16		NA NS EA WA	1226
rs4945044^1,2	H	--	75897610(+)	`TATTTC/GTGTAG`	1	--	ut3¹ ese³		4		NS EA	420
rs191851630^1,2		--	75897726(+)	`GCCAGA/GGGGTC`	1	--	ut3¹		0	--	--	--	--
rs151297166^1,2		--	75897733(+)	`GGTCCC/TGCAGA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for WNT11 (75897369 - 75921803 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WNT11: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WNT11

DNA2.0 Custom Variant and Variant Library Synthesis for WNT11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WNT11 for disorders           About GeneDecksing

OMIM gene information: 603699    OMIM disorders: --

20/21 diseases for WNT11 (see all 21):    About MalaCards

cleft lip/palate cleft lip mass syndrome cleft palate

renal agenesis basal cell carcinoma chronic myeloid leukemia hyperopia

myeloid leukemia strabismus hermaphroditism hepatocellular carcinoma

colorectal cancer leukemia osteosarcoma prostate cancer

breast cancer sarcoma carcinoma prostatitis

2 Novoseek disease relationships for WNT11 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gastric cancer	15.6	2	11712081 (1), 19578797 (1)
tumors	0	2	20103596 (2)

Human Genome Epidemiology (HuGE) Navigator: WNT11 (8 documents)

Export disorders for WNT11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WNT11 gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with WNT11)

Utopia: connect your pdf to the dynamic
world of online information

Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. (PubMed id 9757009)^{1, 2, 3} Lako M.... Lindsay S. (1998)
Molecular cloning and characterization of human WNT11. (PubMed id 11712081)^{1, 2, 9} Kirikoshi H.... Katoh M. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells. (PubMed id 20219091)^{1, 9} Uysal-Onganer P....Kypta R.M. (2010)
Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus. (PubMed id 15708567)^{1, 9} Garriock R.J....Krieg P.A. (2005)
Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration. (PubMed id 20103596)^{1, 9} Toyama T....Kim M. (2010)
Wnt-11 signaling leads to down-regulation of the Wnt/beta-catenin, JNK/AP-1 and NF-kappaB pathways and promotes viability in the CHO-K1 cells. (PubMed id 18572162)^{1, 9} Railo A....Vainio S. (2008)
Notch signaling contributes to the expression of cardiac markers in human circulating progenitor cells. (PubMed id 17967789)^{1, 9} Koyanagi M....Dimmeler S. (2007)
Wingless homolog Wnt11 suppresses bacterial invasion and inflammation in intestinal epithelial cells. (PubMed id 21903761)¹ Liu X....Sun J. (2011)
Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG. (PubMed id 21242973)¹ Mochmann L.H....Baldus C.D. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7481	HGNC: 12776	AceView: WNT11	Ensembl:ENSG00000085741	euGenes: HUgn7481
ECgene: WNT11	Kegg: 7481	H-InvDB: WNT11

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WNT11	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WNT11	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for WNT11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WNT11 gene:
Search GeneIP for patents involving WNT11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore small molecules (inhibitor) for WNT11
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for WNT11 (Wnt-11)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for WNT11 (Wnt-11)

	OriGene Antibodies for WNT11		OriGene shRNA RFP for WNT11
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT11		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT11
	OriGene Protein Over-expression Lysate for WNT11		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for WNT11		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT11		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT11
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for WNT11		OriGene Custom Protein Services for WNT11
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WNT11
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WNT11
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT11
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT11
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT11
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT11

	GenScript Custom Purified and Recombinant Proteins Services for WNT11		GenScript cDNA clones with any tag delivered in your preferred vector for WNT11
	GenScript Custom Assay Services for WNT11		GenScript Custom Superior Antibodies Services for WNT11
	GenScript Custom overexpressing Cell Line Services for WNT11		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in WNT11 promoter
	Search Chromatin IP Primers for WNT11
	RT² qPCR Primer Assay in human, mouse, rat WNT11
	GNC Network for WNT11
	SABiosciences PCR Arrays including human, mouse, rat WNT11

Search Tocris compounds for WNT11

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	WNT11 antibodies
	WNT11 lysates

	Antibodies for WNT11
	See all of Abcam's Antibodies, Kits and Proteins for WNT11
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

WNT11 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for WNT11

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT11

	SwitchGear 3'UTR luciferase reporter plasmids for WNT11
	SwitchGear Promoter luciferase reporter plasmids for WNT11

ThermoFisher Antibody for WNT11

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT11

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes WNT11 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

WNT11 Gene

wingless-type MMTV integration site family, member 11

Aliases
for WNT11 gene

Summaries
for WNT11 gene

Genomic Views
for WNT11 gene

Proteins
for WNT11 gene

Protein Domains /
Families
for WNT11 gene

Function
for WNT11 gene

Pathways & Interactions
for WNT11 gene

Drugs & Compounds
for WNT11 gene

Transcripts
for WNT11 gene

Expression
for WNT11 gene

Orthologs
for WNT11 gene

Paralogs
for WNT11 gene

Genomic Variants
for WNT11 gene

Disorders / Diseases
for WNT11 gene

Publications
for WNT11 gene

External Searches for WNT11 gene

Genome Databases showing WNT11 gene

Other Databases showing WNT11 gene

Specialized Databases showing WNT11 gene

Intellectual Property
for WNT11 gene

Products
for WNT11 gene

View Random Gene

Advanced Search

Export list of displayed genes

WNT11 Gene

wingless-type MMTV integration site family, member 11

Aliasesfor WNT11 gene

Summariesfor WNT11 gene

Genomic Viewsfor WNT11 gene

Proteinsfor WNT11 gene

Protein Domains /Familiesfor WNT11 gene

Functionfor WNT11 gene

Pathways & Interactionsfor WNT11 gene

Drugs & Compoundsfor WNT11 gene

Transcriptsfor WNT11 gene

Expression for WNT11 gene

Orthologsfor WNT11 gene

Paralogsfor WNT11 gene

Genomic Variantsfor WNT11 gene

Disorders / Diseasesfor WNT11 gene

Publicationsfor WNT11 gene

External Searches for WNT11 gene

Genome Databases showing WNT11 gene

Other Databases showing WNT11 gene

Specialized Databases showing WNT11 gene

Intellectual Propertyfor WNT11 gene

Productsfor WNT11 gene

View Random Gene

Aliases
for WNT11 gene

Summaries
for WNT11 gene

Genomic Views
for WNT11 gene

Proteins
for WNT11 gene

Protein Domains /
Families
for WNT11 gene

Function
for WNT11 gene

Pathways & Interactions
for WNT11 gene

Drugs & Compounds
for WNT11 gene

Transcripts
for WNT11 gene

Expression
for WNT11 gene

Orthologs
for WNT11 gene

Paralogs
for WNT11 gene

Genomic Variants
for WNT11 gene

Disorders / Diseases
for WNT11 gene

Publications
for WNT11 gene

Intellectual Property
for WNT11 gene

Products
for WNT11 gene