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WNT10B Gene

protein-coding   GIFtS: 66
GCID: GC12M049359

Wingless-Type MMTV Integration Site Family, Member 10B

  See WNT10B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 10B1 2     WNT-10B Protein2
SHFM62 5     WNT123
WNT-122     Protein Wnt-123
Protein Wnt-10b2     

External Ids:    HGNC: 127751   Entrez Gene: 74802   Ensembl: ENSG000001698847   OMIM: 6019065   UniProtKB: O007443   

Export aliases for WNT10B gene to outside databases

Previous GC identifers: GC12P049449 GC12P049527 GC12M049075 GC12M047645 GC12M046390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT10B Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in
breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is
96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family
member, WNT1, in the chromosome 12q13 region. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT10B Gene:
WNT10B (wingless-type MMTV integration site family, member 10B) is a protein-coding gene. Diseases associated with WNT10B include split-hand/foot malformation 6, and skeletal muscle regeneration. GO annotations related to this gene include receptor agonist activity and frizzled binding. An important paralog of this gene is WNT8B.

UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters (By similarity)

Gene Wiki entry for WNT10B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT10B gene promoter:
         SREBP-1c   E2F-2   HNF-4alpha2   HNF-4alpha1   SREBP-1b   PPAR-gamma1   E2F   E2F-1   SREBP-1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT10B promoter sequence
   Search Chromatin IP Primers for WNT10B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT10B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

WNT10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT10B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049359:  view genomic region     (about GC identifiers)

Start:
49,359,123 bp from pter      End:
49,365,641 bp from pter
Size:
6,519 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744 (See protein sequence)
Recommended Name: Protein Wnt-10b precursor  
Size: 389 amino acids; 43000 Da
Developmental stage: Infant brain has higher levels of WNT10B than adult brain
Secondary accessions: B2R7A5 O00747 Q4VAJ5 Q8WZ97

Explore the universe of human proteins at neXtProt for WNT10B: NX_O00744

Explore proteomics data for WNT10B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn93, Asn335
  • Modification sites at PhosphoSitePlus

  • See WNT10B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003385.2  
    ENSEMBL proteins: 
     ENSP00000301061   ENSP00000384691   ENSP00000385980   ENSP00000398473   ENSP00000404896  
    Reactome Protein details: O00744

    WNT10B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for WNT10B

     
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    antibodies-online proteins for WNT10B (5 products) 

     
    antibodies-online peptides for WNT10B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR005817 Wnt
     IPR013302 Wnt10
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry O00744

    ProtoNet protein and cluster: O00744

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744
    Similarity: Belongs to the Wnt family


    Find genes that share domains with WNT10B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WN10B_HUMAN, O00744
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters (By similarity)

         Genatlas biochemistry entry for WNT10B:
    wingless-type MMTV integration site 10B,Drosophila wingless (Wg) segment polarity gene homolog,expressed in breast
    carcinoma,heart,skeletal muscle,modulating cell fate and cell behavior during vertebrate development

         Summary: 
    During embryonic development, WNT10B as signaling molecule is secreted from the following cells:
                
    Hair: Primary Hair Placode Cells (Hair Follicle)

    It affects the following cells:       fully expand
    Bone: Immature Endochondral Osteoblasts (Autopod Periosteum), Immature Endochondral Osteoblasts (Rib)      fully expand to see all 5 cells
    Hair: Primary Hair Placode Cells (Hair Follicle)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
    GO:0048018receptor agonist activity IC17761539
         
    Find genes that share ontologies with WNT10B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WNT10B:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Wnt10b):
     muscle 

    Find genes that share phenotypes with WNT10B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wnt10btm1Ptr for WNT10B

       genOway: Develop your customized and physiologically relevant rodent model for WNT10B

    miRNA
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    miRTarBase miRNAs that target WNT10B:
    hsa-mir-335-5p (MIRT018883), hsa-mir-98-5p (MIRT027804)

    Block miRNA regulation of human, mouse, rat WNT10B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WNT10B (see all 12):
    hsa-miR-4264 hsa-miR-3934 hsa-miR-148b hsa-miR-1260b hsa-miR-452* hsa-miR-1260 hsa-miR-152 hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidWNT10B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WN10B_HUMAN, O00744: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytosol1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space NAS15135146

    Find genes that share ontologies with WNT10B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT10B About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58


    Find genes that share SuperPaths with WNT10B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT10B
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT10B (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT10B
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT10B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for WNT10B
        Wnt Signaling Pathway
    Adipogenesis
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)

    3 Reactome Pathways for WNT10B
        Transcriptional regulation of white adipocyte differentiation
    WNT ligand biogenesis and trafficking
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT10B) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT10B: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT10B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT10B (ENSP000003010614) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADIPOQENSP000003207094STRING: ENSP00000320709
    CCNCENSP000003582224STRING: ENSP00000358222
    CEBPBENSP000003054224STRING: ENSP00000305422
    CREBBPENSP000002623674STRING: ENSP00000262367
    EBF1ENSP000003228984STRING: ENSP00000322898
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 44):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IEA--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002062chondrocyte differentiation IEP15135146
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006629lipid metabolic process IEA--

    Find genes that share ontologies with WNT10B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    7 ApexBio Compounds for WNT10B     About this table
    CompoundAction CAS #
    CHIR-99021 (CT99021)Cell-permeable, ATP-competitive GSK-3 inhibitor[252917-06-9]
    FH535suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. [108409-83-2]
    ICG 001Wnt/beta-catenin path[847591-62-2]
    JW 55Cell-permeable, reversible tankyrase 1 and 2 inhibitor, inhibits beta-catenin mediated canonical Wnt pathway[664993-53-7]
    KY 02111Canonical Wnt pathway inhibitor, promotes stem cell differentiation to cadiomyocytes[1118807-13-8]
    Salinomycin sodium saltantibacterial and coccidiostat ionophore therapeutic drug[55721-31-8]
    XAV-939Tankyrase inhibitor, also inhibits beta-catenin mediated Wnt pathway[284028-89-3]

    Browse Tocris compounds for WNT10B (WN10B)

    2 Novoseek inferred chemical compound relationships for WNT10B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 25.6 1 12213737 (1)
    progesterone 14.3 1 12213737 (1)



    Find genes that share compounds with WNT10B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WNT10B gene: 
    NM_003394.3  

    Unigene Cluster for WNT10B:

    Wingless-type MMTV integration site family, member 10B
    Hs.91985  [show with all ESTs]
    Unigene Representative Sequence: NM_003394
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301061(uc001rss.3 uc001rst.3) ENST00000407467 ENST00000403957
    ENST00000413630 ENST00000475740 ENST00000420388
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    hsa-miR-4264 hsa-miR-3934 hsa-miR-148b hsa-miR-1260b hsa-miR-452* hsa-miR-1260 hsa-miR-152 hsa-miR-2355-5p
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      QuantiFast Probe-based Assays in human, mouse, rat WNT10B

    Additional mRNA sequence: 

    AB070724.1 AK312906.1 BC096353.3 BC096354.1 BC096356.1 U81787.1 X97057.1 

    6 DOTS entries:

    DT.213357  DT.121205165  DT.95156828  DT.75101700  DT.121010219  DT.453494 

    4 AceView cDNA sequences:

    AB070724 NM_003394 X97057 U81787 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT10B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCTTGGAG
    WNT10B Expression
    About this image


    WNT10B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Epithelial Cells
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Dental Placode Cells Dental Placode
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Bone (Muscoskeletal System)
             Mandibular Process
    WNT10B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT10B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.91985

    UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744
    Tissue specificity: Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low
    levels are found in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT10B: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT10B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WNT10B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt10b1 , 5 wingless related MMTV integration site 10b1, 5 90.16(n)1
    97.54(a)1
      15 (54.65 cM)5
    224101  NM_011718.21  NP_035848.11 
     987717535 
    chicken
    (Gallus gallus)
    Aves --
    Protein Wnt
    34(a)
    many ↔ many
    1(24479734-24484331)
    lizard
    (Anolis carolinensis)
    Reptilia WNT10B6
    wingless-type MMTV integration site family, member...
    60(a)
    1 ↔ 1
    2(94100765-94116887)
    African clawed frog
    (Xenopus laevis)
    Amphibia wnt10-A2 wnt-1 related (wnt-10), wingless-type MMTV integration more 73.64(n)    L07530.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt10b2 wingless-type MMTV integration site family, member more 76.74(n)   30308  AY182171.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wnt101 , 3 frizzled-2 receptor signaling pathway
    signal transducer3
    Wnt oncogene analog 101
    42(a)3
    54.14(n)1
    47.63(a)1
      27F33
    340111  NM_135265.41  NP_609109.31 
    worm
    (Caenorhabditis elegans)
    Secernentea mom-26
    Protein MOM-2 (mom-2) mRNA, complete cds
    30(a)
    many ↔ many
    V(8355988-8358188) WBGene00003395


    ENSEMBL Gene Tree for WNT10B (if available)
    TreeFam Gene Tree for WNT10B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT10B gene
    WNT8B2  WNT8A2  WNT9B2  WNT10A2  WNT9A2  
    13 SIMAP similar genes for WNT10B using alignment to 5 protein entries:     WN10B_HUMAN (see all proteins):
    WNT10A    WNT4    WNT2    WNT7B    WNT7A    WNT5B
    WNT5A    WNT6    WNT1    WNT3A    WNT2B    WNT11
    WNT3

    Find genes that share paralogs with WNT10B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WNT10B (see all 187)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0625164
    Split-hand/foot malformation 6 (SHFM6)4--see VAR_0625162 R W mis40--------
    rs724053191,2
    C--46397213(+) TCCCA-/GCGC  
            
    GCGCG
    1 -- ut510--------
    rs1380877451,2
    C--49191647(+) ATGAAG/TTTTTA 1 -- ds50010--------
    rs1410113161,2
    C--49191661(+) GACACA/GGCCAC 1 -- ds50010--------
    rs1845821181,2
    --49191667(+) GCCACA/GCTCAT 1 -- ds50010--------
    rs1905861121,2
    --49191699(+) CTGCTA/GTTGAT 1 -- ds50010--------
    rs1140640081,2
    F--49191829(+) GTTCTA/GAGGCA 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs37823531,2
    C,F,A,H--49191864(+) GAGGCG/ACATAG 1 -- ds5001109Minor allele frequency- A:0.38EA NS NA PA EU CA WA CSA 8340
    rs1924429291,2
    --49192030(+) AGGTAA/GGAGAA 1 -- ds50010--------
    rs1175542661,2
    C,F--49192050(+) AAAAGA/CAGCTA 1 -- ds50011Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for WNT10B (49359123 - 49365641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WNT10B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832404CNV Gain17160897

    Human Gene Mutation Database (HGMD): WNT10B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT10B
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT10B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601906   
    OMIM disorders: 225300  
    UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744
  • Split-hand/foot malformation 6 (SHFM6) [MIM:225300]: A limb malformation involving the central rays of
    the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of
    the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal
    and craniofacial findings, and orofacial clefting. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 3 diseases for WNT10B:    
    About MalaCards
    split-hand/foot malformation 6    skeletal muscle regeneration    breast cancer


    Find genes that share disorders with WNT10B           About GenesLikeMe

    10 Novoseek inferred disease relationships for WNT10B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mammary tumor 68.7 2 8738604 (1), 12429977 (1)
    gastric cancer 41.8 3 12239602 (2), 11713588 (1)
    pancreatic cancer 41.3 1 12239602 (1)
    cervical cancer 37.9 2 12239602 (2)
    breast cancer 31.3 3 12239602 (1), 9121776 (1)
    cancer 25 5 12239602 (2), 9121776 (1)
    necrosis 15.5 1 12239602 (1)
    tumors 14.3 3 12213737 (1), 12239602 (1)
    carcinoma squamous cell 12.2 1 12239602 (1)
    carcinoma 0 2 9121776 (1), 15300008 (1)

    Genetic Association Database (GAD): WNT10B
    Human Genome Epidemiology (HuGE) Navigator: WNT10B (10 documents)
    Tumor Gene Database (TGDB): WNT10B

    Export disorders for WNT10B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT10B gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with WNT10B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas. (PubMed id 9121776)1, 2, 3, 9 Bui T.D.... Lindsay S. (Oncogene 1997)
    2. Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation. (PubMed id 18515319)1, 2, 3 Ugur S.A. and Tolun A. (Hum. Mol. Genet. 2008)
    3. Isolation, characterization and chromosomal localization of human WNT10B. (PubMed id 9284937)1, 2, 3 Hardiman G.... Bazan J.F. (Cytogenet. Cell Genet. 1997)
    4. Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45. (PubMed id 11713588)1, 2, 9 Saitoh T.... Katoh M. (Int. J. Oncol. 2001)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Polymorphisms of the WNT10B gene, bone mineral density, and fractures in postmenopausal women. (PubMed id 19458884)1, 4 Perez-Castrillon J.L....Riancho J.A. (Calcif. Tissue Int. 2009)
    8. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    9. Association analysis of WNT10B with bone mass and structure among individuals of African ancestry. (PubMed id 19016593)1, 4 Zmuda J.M....Ferrell R.E. (J. Bone Miner. Res. 2009)
    10. WNT10B mutations in human obesity. (PubMed id 16477437)1, 2 Christodoulides C.... Vettor R. (Diabetologia 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7480 HGNC: 12775 AceView: WNT10B Ensembl:ENSG00000169884 euGenes: HUgn7480
    ECgene: WNT10B Kegg: 7480 H-InvDB: WNT10B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WNT10B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT10B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT10B gene:
    Search GeneIP for patents involving WNT10B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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