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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WNT10B Gene

protein-coding GIFtS: 65
GCID: GC12M049359

wingless-type MMTV integration site family, member 10B

Explore 17 diseases affiliated with
WNT10B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 10B¹ ²		WNT-10B Protein²
SHFM6¹ ² ⁵		WNT12³
WNT-12¹ ²		Protein Wnt-12³
Protein Wnt-10b²

External Ids:	HGNC: 12775¹	Entrez Gene: 7480²	Ensembl: ENSG00000169884⁷	OMIM: 601906⁵	UniProtKB: O00744³

Export aliases for WNT10B gene to outside databases

Previous GC identifers: GC12P049449 GC12P049527 GC12M049075 GC12M047645 GC12M046390

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT10B:

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins

have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and

patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer,

and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the

mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the

chromosome 12q13 region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over

only few cell diameters (By similarity)

Gene Wiki entry for WNT10B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WNT10B gene promoter:
SREBP-1c E2F-2 HNF-4alpha2 HNF-4alpha1 SREBP-1b PPAR-gamma1 E2F E2F-1 SREBP-1a PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT10B promoter sequence

Search SABiosciences Chromatin IP Primers for WNT10B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT10B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13

WNT10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT10B gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M049359: view genomic region (about GC identifiers)

Start:	49,359,123 bp from pter	End:	49,365,641 bp from pter
Size:	6,519 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744 (See protein sequence)

Recommended Name: Protein Wnt-10b precursor

Size: 389 amino acids; 43000 Da

Subcellular location: Secreted, extracellular space, extracellular matrix

Developmental stage: Infant brain has higher levels of WNT10B than adult brain

Secondary accessions: B2R7A5 O00747 Q4VAJ5 Q8WZ97

Explore the universe of human proteins at neXtProt for WNT10B: NX_O00744

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00744

WNT10B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003385.2

ENSEMBL proteins:

ENSP00000301061 ENSP00000384691 ENSP00000385980 ENSP00000398473 ENSP00000404896

Reactome Protein details: O00744
Human Recombinant Protein Products:

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	Novus Biologicals WNT10B Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for WNT10B

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	NAS	15135146
GO:0005886	plasma membrane	IBA	--

WNT10B for ontologies About GeneDecksing

WNT10B Antibody Products:

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	GenScript Custom Superior Antibodies Services for WNT10B
	Novus Biologicals WNT10B Antibodies
	Search for Antibodies for WNT10B at Abcam
	Uscn Antibodies for WNT10B
	ThermoFisher Antibody for WNT10B

Assay Products for WNT10B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for WNT10B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for WNT10B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WNT10B for domains About GeneDecksing

3 InterPro domains/families:

IPR005817 Wnt

IPR013302 Wnt10

IPR018161 Wnt_CS

Graphical View of Domain Structure for InterPro Entry O00744

ProtoNet protein and cluster: O00744

1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744

Similarity: Belongs to the Wnt family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over

only few cell diameters (By similarity)

Genatlas biochemistry entry for WNT10B:

wingless-type MMTV integration site 10B,Drosophila wingless (Wg) segment polarity gene homolog,expressed in breast

carcinoma,heart,skeletal muscle,modulating cell fate and cell behavior during vertebrate development

Summary:

During embryonic development, WNT10B as signaling molecule

affects the following cells: Immature Endochondral Osteoblasts in Sacral Vertebrae, Immature Endochondral Osteoblasts in Autopod Periosteum (see all 8).

miRNA Products:		OriGene 3'-UTR Clone: WNT10B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT10B
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT10B (see all 12):
		hsa-miR-4264 hsa-miR-3934 hsa-miR-148b hsa-miR-1260b hsa-miR-452* hsa-miR-1260 hsa-miR-152 hsa-miR-2355-5p

		SwitchGear 3'UTR luciferase reporter plasmid: WNT10B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT10B (see all 7) OriGene shRNA RFP: WNT10B OriGene siRNA: WNT10B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT10B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for WNT10B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT10B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for WNT10B
		Search LifeMap BioReagents cell lines for WNT10B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT10B

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein coupled receptor binding	IBA	--
GO:0005102	receptor binding	--	--
GO:0048018	receptor agonist activity	IC	17761539

WNT10B for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for WNT10B:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Wnt10b^tm1Ptr for WNT10B
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Wnt10b):

muscle

WNT10B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt Signaling Pathway	0.33
Wnt Signaling Pathway and Pluripotency	0.55	Wnt signaling pathway	0.30
DNA damage response (only ATM dependent)	0.35

Basal cell carcinoma

	Basal cell carcinoma	1.00			Wnt Pathway	0.37
	Hedgehog signaling pathway	0.41			Melanogenesis	0.32

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for WNT10B

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for WNT10B

Wnt Signaling Pathway

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT10B (see all 7)

	GSK3 Signaling
	Presenilin-Mediated Signaling
	Colorectal Cancer Metastasis
	Human Embryonic Stem Cell Pluripotency
	Nanog in Mammalian ESC Pluripotency

1 Tocris Bioscience Pathway for WNT10B

Wnt Pathway

2 GeneGo (Thomson Reuters) Pathways for WNT10B

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

4 BioSystems Pathways for WNT10B

	Wnt Signaling Pathway and Pluripotency
	DNA damage response (only ATM dependent)
	Adipogenesis
	Wnt Signaling Pathway

4 Reactome Pathways for WNT10B

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

5 Kegg Pathways (Kegg details for WNT10B):

	Wnt signaling pathway
	Hedgehog signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

WNT10B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for WNT10B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/64 Interacting proteins for WNT10B (ENSP00000301061⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 64)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADIPOQ	ENSP00000320709⁴	STRING: ENSP00000320709
CCNC	ENSP00000358222⁴	STRING: ENSP00000358222
CEBPB	ENSP00000305422⁴	STRING: ENSP00000305422
EBF1	ENSP00000322898⁴	STRING: ENSP00000322898
FABP4	ENSP00000256104⁴	STRING: ENSP00000256104

About this table

Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	IEA	--
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0002062	chondrocyte differentiation	IEP	15135146
GO:0006357	regulation of transcription from RNA polymerase II promoter	--	--
GO:0006629	lipid metabolic process	IEA	--

WNT10B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

WNT10B for compounds About GeneDecksing

EMD Millipore small molecules for WNT10B:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WNT10B
2 Novoseek chemical compound relationships for WNT10B gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen	25.6	1	12213737 (1)
progesterone	14.3	1	12213737 (1)

Search CenterWatch for drugs/clinical trials and news about WNT10B / WN10B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WNT10B gene:

NM_003394.3

Unigene Cluster for WNT10B:

Wingless-type MMTV integration site family, member 10B

Hs.91985 [show with all ESTs]

Unigene Representative Sequence: NM_003394

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000301061(uc001rss.3 uc001rst.3) ENST00000407467 ENST00000403957

ENST00000413630 ENST00000475740 ENST00000420388

miRNA Products:		OriGene 3'-UTR Clone: WNT10B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT10B
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT10B (see all 12):
		hsa-miR-4264 hsa-miR-3934 hsa-miR-148b hsa-miR-1260b hsa-miR-452* hsa-miR-1260 hsa-miR-152 hsa-miR-2355-5p

		SwitchGear 3'UTR luciferase reporter plasmid: WNT10B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT10B

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		GenScript: all cDNA clones in your preferred vector: WNT10B (NM_003394)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT10B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT10B

Additional cDNA sequence:

AB070724.1 AK312906.1 BC096353.3 BC096354.1 BC096356.1 U81787.1 X97057.1

6 DOTS entries:

DT.213357 DT.121205165 DT.95156828 DT.75101700 DT.121010219 DT.453494

4 AceView cDNA sequences:

AB070724 NM_003394 U81787 X97057

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WNT10B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCTTGGAG

About this image

WNT10B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Granulosa Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See WNT10B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WNT10B

SOURCE GeneReport for Unigene cluster: Hs.91985

UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744

Tissue specificity: Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels

are found in brain

SABiosciences Expression via Pathway-Focused PCR Arrays including WNT10B:

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Pathway in human mouse rat

Adipogenesis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT10B Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT10B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT10B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for WNT10B gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	WNT10B⁶	--	59(a)	1 ↔ 1	2(94100765-94116278)
African clawed frog (Xenopus laevis)	Amphibia	wnt10-A²	wnt-1 related (wnt-10), wingless-type MMTV integration more	73.64(n)		L07530.1
zebrafish (Danio rerio)	Actinopterygii	wnt10b²	wingless-type MMTV integration site family, member more	76.74(n)		30308 AY182171.1
fruit fly (Drosophila melanogaster)	Insecta	Wnt10^{1 , 3}	frizzled-2 receptor signaling pathway signal transducer³ CG4971-PB¹	42(a)³ 52.06(n)¹ 45.67(a)¹		27F3³ 34011¹ NM_135265.3¹ NP_609109.3¹
worm (Caenorhabditis elegans)	Secernentea	mom-2⁶	Protein mom-2	28(a)	1 → many	V(8355968-8358168)

ENSEMBL Gene Tree for WNT10B (if available)
TreeFam Gene Tree for WNT10B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WNT10B gene

WNT5B² WNT16² WNT5A² WNT6² WNT11² WNT2² WNT2B² WNT3A²

WNT1² WNT4² WNT7A² WNT7B² WNT10A² WNT3²

16 SIMAP similar genes for WNT10B using alignment to 5 protein entries: WN10B_HUMAN (see all proteins):

WNT10A WNT4 WNT2 WNT7B WNT7A WNT5B

WNT5A WNT6 WNT1 WNT3A WNT2B WNT11

WNT3 WNT8A WNT16 WNT8B

WNT10B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77211836^1,2	C,F,	--	46391285(+)	`TCCAAT/CTGTTG`	1	--	ut3¹		1		WA	118
rs112707891^1,2	C,	--	46392645(+)	`AGCGAC/TTCTCC`	1	--	int¹		1		NA	2
rs80277738^1,2	F,	--	46394417(+)	`CTTTGT/CTATGT`	1	--	int¹		1		WA	118
rs79840715^1,2	C,	--	46394765(+)	`CCCCC-/TTCTCT`	1	--	int¹		0	--	--	--	--
rs78257842^1,2		--	46395580(+)	`ACCCTC/GAAGCG`	2	Q E	mis¹		0	--	--	--	--
rs78826366^1,2	F,	--	46397200(+)	`AGCCTC/ACCCCT`	1	--	ut5¹		1		WA	118
rs17123468^1,2		--	46397613(-)	`GACGTG/CTGCTT`	1	--	us2k¹		3		MN EA	476
rs833838^1,2	F,H	--	46398991(-)	`AGCTCA/GGGCCA`	1	--	us2k¹ tfbs³		6		NS EA NA	392
rs138087745^1,2		--	49358663(+)	`ATGAAG/TTTTTA`	1	--	ds500¹		0	--	--	--	--
rs141011316^1,2		--	49358677(+)	`GACACA/GGCCAC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for WNT10B (49359123 - 49365641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WNT10B
1 CNV: 4777
Human Gene Mutation Database (HGMD): WNT10B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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WNT10B for disorders           About GeneDecksing

OMIM gene information: 601906
OMIM disorders: 225300
UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744

Defects in WNT10B are the cause of split-hand/foot malformation type 6 (SHFM6) [MIM:225300]. SHFM is a limb

malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and

feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. SHFM6 is a autosomal recessive

disorder

17 diseases for WNT10B: About MalaCards

split hand/foot malformation split-hand/foot malformation 6 breast cancer skeletal muscle regeneration

basal cell carcinoma syndactyly gastric cancer endometrial carcinoma

hermaphroditism carcinoma ovarian cancer breast carcinoma

osteosarcoma obesity neuroblastoma neuronitis

colorectal cancer

10 Novoseek disease relationships for WNT10B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mammary tumor	68.7	2	8738604 (1), 12429977 (1)
gastric cancer	41.8	3	12239602 (2), 11713588 (1)
pancreatic cancer	41.3	1	12239602 (1)
cervical cancer	37.9	2	12239602 (2)
breast cancer	31.3	3	12239602 (1), 9121776 (1)
cancer	25	5	12239602 (2), 9121776 (1)
necrosis	15.5	1	12239602 (1)
tumors	14.3	3	12213737 (1), 12239602 (1)
carcinoma squamous cell	12.2	1	12239602 (1)
carcinoma	0	2	9121776 (1), 15300008 (1)

Human Genome Epidemiology (HuGE) Navigator: WNT10B (10 documents)
Tumor Gene Database (TGDB): WNT10B

Export disorders for WNT10B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for WNT10B gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with WNT10B)

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A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas. (PubMed id 9121776)^{1, 2, 3, 9} Bui T.D.... Lindsay S. (1997)
Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation. (PubMed id 18515319)^{1, 2, 3} Ugur S.A. and Tolun A. (2008)
Isolation, characterization and chromosomal localization of human WNT10B. (PubMed id 9284937)^{1, 2, 3} Hardiman G.... Bazan J.F. (1997)
Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45. (PubMed id 11713588)^{1, 2, 9} Saitoh T.... Katoh M. (2001)
WNT10B mutations in human obesity. (PubMed id 16477437)^{1, 2} Christodoulides C.... Vettor R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PubMed id 9441749)^{1, 2} Bergstein I.... Brown A.M.C. (1997)
WNT10A and WNT6, clustered in human chromosome 2q35 region with head- to-tail manner, are strongly co-expressed in SW480 cells. (PubMed id 11350055)^{1, 9} Kirikoshi H.... Katoh M. (2001)
Wnt/b-catenin pathway forms a negative feedback loop d uring TGF-b1 induced human normal skin fibroblast-to-myofibroblast transition. (PubMed id 22041457)¹ Liu J....Hu D. (2012)
Genetic association between WNT10B polymorphisms and o besity in a Belgian case-control population is restricted to males. (PubMed id 22189080)¹ Van Camp J.K....Van Hul W. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7480	HGNC: 12775	AceView: WNT10B	Ensembl:ENSG00000169884	euGenes: HUgn7480
ECgene: WNT10B	Kegg: 7480	H-InvDB: WNT10B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WNT10B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WNT10B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for WNT10B gene
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Patent Information for WNT10B gene:
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WNT10B Gene

wingless-type MMTV integration site family, member 10B

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WNT10B Gene

wingless-type MMTV integration site family, member 10B

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