Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WNT10B Gene

Aliases for WNT10B Gene

  • Wnt Family Member 10B 2 3
  • Wingless-Type MMTV Integration Site Family, Member 10B 2 3
  • Wingless-Type MMTV Integration Site Family Member 10B 3 5
  • WNT-10B Protein 3
  • Protein Wnt-12 4
  • WNT-12 3
  • SHFM6 3
  • WNT12 4

External Ids for WNT10B Gene

Previous GeneCards Identifiers for WNT10B Gene

  • GC12P049449
  • GC12P049527
  • GC12M049075
  • GC12M047645
  • GC12M049359
  • GC12M046390

Summaries for WNT10B Gene

Entrez Gene Summary for WNT10B Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT10B Gene

WNT10B (Wnt Family Member 10B) is a Protein Coding gene. Diseases associated with WNT10B include split-hand/foot malformation 6 and split hand-split foot malformation. Among its related pathways are Signaling by GPCR and Developmental Biology. GO annotations related to this gene include receptor binding and receptor agonist activity. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot for WNT10B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Wiki entry for WNT10B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT10B Gene

Genomics for WNT10B Gene

Regulatory Elements for WNT10B Gene

Promoters for WNT10B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WNT10B on UCSC Golden Path with GeneCards custom track

Genomic Location for WNT10B Gene

Chromosome:
12
Start:
48,965,340 bp from pter
End:
48,971,858 bp from pter
Size:
6,519 bases
Orientation:
Minus strand

Genomic View for WNT10B Gene

Genes around WNT10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT10B Gene

Proteins for WNT10B Gene

  • Protein details for WNT10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00744-WN10B_HUMAN
    Recommended name:
    Protein Wnt-10b
    Protein Accession:
    O00744
    Secondary Accessions:
    • B2R7A5
    • O00747
    • Q4VAJ4
    • Q4VAJ5
    • Q8WZ97

    Protein attributes for WNT10B Gene

    Size:
    389 amino acids
    Molecular mass:
    43000 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WNT10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT10B Gene

Proteomics data for WNT10B Gene at MOPED

Post-translational modifications for WNT10B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn 93 and Asn 335
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT10B Gene

Antibody Products

No data available for DME Specific Peptides for WNT10B Gene

Domains & Families for WNT10B Gene

Gene Families for WNT10B Gene

Protein Domains for WNT10B Gene

Suggested Antigen Peptide Sequences for WNT10B Gene

Graphical View of Domain Structure for InterPro Entry

O00744

UniProtKB/Swiss-Prot:

WN10B_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT10B: view

Function for WNT10B Gene

Molecular function for WNT10B Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 10B,Drosophila wingless (Wg) segment polarity gene homolog,expressed in breast carcinoma,heart,skeletal muscle,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
genes like me logo Genes that share phenotypes with WNT10B: view

Human Phenotype Ontology for WNT10B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNT10B Gene

MGI Knock Outs for WNT10B:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT10B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for WNT10B Gene

Localization for WNT10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT10B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT10B Gene COMPARTMENTS Subcellular localization image for WNT10B gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for WNT10B Gene

Pathways & Interactions for WNT10B Gene

genes like me logo Genes that share pathways with WNT10B: view

Interacting Proteins for WNT10B Gene

SIGNOR curated interactions for WNT10B Gene

Gene Ontology (GO) - Biological Process for WNT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0002062 chondrocyte differentiation IEP 15135146
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with WNT10B: view

Drugs & Compounds for WNT10B Gene

(7) Drugs for WNT10B Gene - From: Novoseek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FH535 Pharma Wnt/B-catenin inhibitor 0
IWR-1-endo Pharma Potent Wnt signaling inhibitor 0
Kartogenin Pharma 0
KY 02111 Pharma WNT signaling inhibitor 0
LGK-974 Pharma PORCN inhibitor,potent and specific 0

(1) Additional Compounds for WNT10B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(6) ApexBio Compounds for WNT10B Gene

Compound Action Cas Number
FH535 Wnt/B-catenin inhibitor 108409-83-2
IWR-1-endo Potent Wnt signaling inhibitor 1127442-82-3
Kartogenin 4727-31-5
KY 02111 WNT signaling inhibitor 1118807-13-8
LGK-974 PORCN inhibitor,potent and specific 1243244-14-5
Wnt-C59 PORCN inhibitor,highly potent and selective 1243243-89-1
genes like me logo Genes that share compounds with WNT10B: view

Transcripts for WNT10B Gene

mRNA/cDNA for WNT10B Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT10B Gene

Wingless-type MMTV integration site family, member 10B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WNT10B Gene

No ASD Table

Relevant External Links for WNT10B Gene

GeneLoc Exon Structure for
WNT10B
ECgene alternative splicing isoforms for
WNT10B

Expression for WNT10B Gene

mRNA expression in normal human tissues for WNT10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT10B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.9), Brain - Cortex (x6.2), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Putamen (basal ganglia) (x4.9), Brain - Frontal Cortex (BA9) (x4.9), Brain - Caudate (basal ganglia) (x4.1), and Brain - Amygdala (x4.0).

Protein differential expression in normal tissues from HIPED for WNT10B Gene

This gene is overexpressed in Cervix (45.1), Plasma (14.0), and Heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT10B Gene



SOURCE GeneReport for Unigene cluster for WNT10B Gene Hs.91985

mRNA Expression by UniProt/SwissProt for WNT10B Gene

O00744-WN10B_HUMAN
Tissue specificity: Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.
genes like me logo Genes that share expression patterns with WNT10B: view

Protein tissue co-expression partners for WNT10B Gene

Primer Products

In Situ Assay Products

Orthologs for WNT10B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT10B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WNT10B 35
  • 91.92 (n)
  • 95.1 (a)
WNT10B 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT10B 35
  • 93.21 (n)
  • 97.88 (a)
mouse
(Mus musculus)
Mammalia Wnt10b 35
  • 90.16 (n)
  • 97.54 (a)
Wnt10b 16
Wnt10b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WNT10B 35
  • 99.06 (n)
  • 98.71 (a)
WNT10B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt10b 35
  • 90.44 (n)
  • 97.54 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia WNT10B 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt10b 35
  • 66.67 (n)
  • 71.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia wnt10-A 35
zebrafish
(Danio rerio)
Actinopterygii wnt10b 35
  • 66.39 (n)
  • 68.13 (a)
wnt10b 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt10 37
  • 42 (a)
Wnt10 35
  • 54.14 (n)
  • 47.63 (a)
Wnt10 36
  • 34 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009731 35
  • 45.97 (n)
  • 36.82 (a)
worm
(Caenorhabditis elegans)
Secernentea mom-2 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for WNT10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT10B Gene

ENSEMBL:
Gene Tree for WNT10B (if available)
TreeFam:
Gene Tree for WNT10B (if available)

Paralogs for WNT10B Gene

Paralogs for WNT10B Gene

(13) SIMAP similar genes for WNT10B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WNT10B: view

Variants for WNT10B Gene

Sequence variations from dbSNP and Humsavar for WNT10B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs151284263 - 48,970,197(+) GATGT(A/G)CAGAC upstream-variant-2KB, reference, missense, utr-variant-5-prime
VAR_062513 -
VAR_062514 -
rs35034312 - 48,966,364(+) ACGGG(A/G)ACGCA downstream-variant-500B, reference, missense, utr-variant-3-prime
VAR_062516 Split-hand/foot malformation 6 (SHFM6)

Structural Variations from Database of Genomic Variants (DGV) for WNT10B Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV Gain 17160897

Variation tolerance for WNT10B Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT10B Gene

HapMap Linkage Disequilibrium report
WNT10B
Human Gene Mutation Database (HGMD)
WNT10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT10B Gene

Disorders for WNT10B Gene

MalaCards: The human disease database

(6) MalaCards diseases for WNT10B Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
split-hand/foot malformation 6
  • ectrodactyly, autosomal recessive
split hand-split foot malformation
  • split hand foot malformation
split hand foot malformation
  • ectrodactyly
split hand
skeletal muscle regeneration
  • nonaka myopathy
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

WN10B_HUMAN
  • Split-hand/foot malformation 6 (SHFM6) [MIM:225300]: A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. {ECO:0000269 PubMed:18515319}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for WNT10B

Genetic Association Database (GAD)
WNT10B
Human Genome Epidemiology (HuGE) Navigator
WNT10B
Tumor Gene Database (TGDB):
WNT10B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT10B
genes like me logo Genes that share disorders with WNT10B: view

No data available for Genatlas for WNT10B Gene

Publications for WNT10B Gene

  1. A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas. (PMID: 9121776) Bui T.D. … Lindsay S. (Oncogene 1997) 2 3 4 23 67
  2. Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation. (PMID: 18515319) Ugur S.A. … Tolun A. (Hum. Mol. Genet. 2008) 2 3
  3. WNT10A and WNT6, clustered in human chromosome 2q35 region with head- to-tail manner, are strongly co-expressed in SW480 cells. (PMID: 11350055) Kirikoshi H. … Katoh M. (Biochem. Biophys. Res. Commun. 2001) 3 23
  4. Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45. (PMID: 11713588) Saitoh T. … Katoh M. (Int. J. Oncol. 2001) 3 23
  5. Isolation, characterization and chromosomal localization of human WNT10B. (PMID: 9284937) Hardiman G. … Bazan J.F. (Cytogenet. Cell Genet. 1997) 2 3

Products for WNT10B Gene

Sources for WNT10B Gene

Back to Top

Content