Aliases for WNT10B Gene
External Ids for WNT10B Gene
Previous GeneCards Identifiers for WNT10B Gene
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT10B Gene
WNT10B (Wingless-Type MMTV Integration Site Family, Member 10B) is a Protein Coding gene. Diseases associated with WNT10B include split-hand/foot malformation 6 and split hand foot malformation. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include frizzled binding and receptor agonist activity. An important paralog of this gene is WNT8B.
UniProtKB/Swiss-Prot for WNT10B Gene
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).