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Aliases for WNT10B Gene

Aliases for WNT10B Gene

  • Wingless-Type MMTV Integration Site Family, Member 10B 2 3
  • SHFM6 3 6
  • WNT-10B Protein 3
  • Protein Wnt-10b 3
  • Protein Wnt-12 4
  • WNT-12 3
  • WNT12 4

External Ids for WNT10B Gene

Previous GeneCards Identifiers for WNT10B Gene

  • GC12P049449
  • GC12P049527
  • GC12M049075
  • GC12M047645
  • GC12M049359
  • GC12M046390

Summaries for WNT10B Gene

Entrez Gene Summary for WNT10B Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT10B Gene

WNT10B (Wingless-Type MMTV Integration Site Family, Member 10B) is a Protein Coding gene. Diseases associated with WNT10B include split-hand/foot malformation 6 and split hand foot malformation. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include frizzled binding and receptor agonist activity. An important paralog of this gene is WNT8B.

UniProtKB/Swiss-Prot for WNT10B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Wiki entry for WNT10B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT10B Gene

Genomics for WNT10B Gene

Regulatory Elements for WNT10B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WNT10B Gene

Start:
48,965,340 bp from pter
End:
48,971,858 bp from pter
Size:
6,519 bases
Orientation:
Minus strand

Genomic View for WNT10B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT10B Gene

Proteins for WNT10B Gene

  • Protein details for WNT10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00744-WN10B_HUMAN
    Recommended name:
    Protein Wnt-10b
    Protein Accession:
    O00744
    Secondary Accessions:
    • B2R7A5
    • O00747
    • Q4VAJ4
    • Q4VAJ5
    • Q8WZ97

    Protein attributes for WNT10B Gene

    Size:
    389 amino acids
    Molecular mass:
    43000 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WNT10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT10B Gene

Proteomics data for WNT10B Gene at MOPED

Post-translational modifications for WNT10B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn93 and Asn335
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT10B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WNT10B Gene

Domains for WNT10B Gene

Gene Families for WNT10B Gene

HGNC:
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT10B Gene

Suggested Antigen Peptide Sequences for WNT10B Gene

Graphical View of Domain Structure for InterPro Entry

O00744

UniProtKB/Swiss-Prot:

WN10B_HUMAN :
  • O00744
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT10B: view

Function for WNT10B Gene

Molecular function for WNT10B Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 10B,Drosophila wingless (Wg) segment polarity gene homolog,expressed in breast carcinoma,heart,skeletal muscle,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Ontology (GO) - Molecular Function for WNT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005109 frizzled binding IBA --
GO:0048018 receptor agonist activity IC 17761539
genes like me logo Genes that share ontologies with WNT10B: view

Phenotypes for WNT10B Gene

MGI mutant phenotypes for WNT10B:
inferred from 1 alleles
GenomeRNAi human phenotypes for WNT10B:
genes like me logo Genes that share phenotypes with WNT10B: view

Animal Models for WNT10B Gene

MGI Knock Outs for WNT10B:

Animal Model Products

miRNA for WNT10B Gene

miRTarBase miRNAs that target WNT10B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT10B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WNT10B Gene

Localization for WNT10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT10B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT10B Gene COMPARTMENTS Subcellular localization image for WNT10B gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WNT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space NAS 15135146
genes like me logo Genes that share ontologies with WNT10B: view

Pathways for WNT10B Gene

genes like me logo Genes that share pathways with WNT10B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for WNT10B Gene

Gene Ontology (GO) - Biological Process for WNT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0002062 chondrocyte differentiation IEP 15135146
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with WNT10B: view

Compounds for WNT10B Gene

(6) ApexBio Compounds for WNT10B Gene

Compound Action Cas Number
FH535 Wnt/B-catenin inhibitor [108409-83-2]
IWR-1-endo Potent Wnt signaling inhibitor [1127442-82-3]
Kartogenin [4727-31-5]
KY 02111 WNT signaling inhibitor [1118807-13-8]
LGK-974 "PORCN inhibitor,potent and specific" [1243244-14-5]
Wnt-C59 "PORCN inhibitor,highly potent and selective" [1243243-89-1]

(2) Novoseek inferred chemical compound relationships for WNT10B Gene

Compound -log(P) Hits PubMed IDs
glycogen 25.6 1
progesterone 14.3 1
genes like me logo Genes that share compounds with WNT10B: view

Transcripts for WNT10B Gene

mRNA/cDNA for WNT10B Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT10B Gene

Wingless-type MMTV integration site family, member 10B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT10B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT10B Gene

No ASD Table

Relevant External Links for WNT10B Gene

GeneLoc Exon Structure for
WNT10B
ECgene alternative splicing isoforms for
WNT10B

Expression for WNT10B Gene

mRNA expression in normal human tissues for WNT10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT10B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (6.9), Brain - Cortex (6.2), Brain - Anterior cingulate cortex (BA24) (5.0), Brain - Putamen (basal ganglia) (4.9), Brain - Frontal Cortex (BA9) (4.9), Brain - Caudate (basal ganglia) (4.1), and Brain - Amygdala (4.0).

Protein differential expression in normal tissues for WNT10B Gene

This gene is overexpressed in Cervix (45.1), Plasma (14.0), and Heart (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WNT10B Gene

SOURCE GeneReport for Unigene cluster for WNT10B Gene Hs.91985

mRNA Expression by UniProt/SwissProt for WNT10B Gene

O00744-WN10B_HUMAN
Tissue specificity: Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain
genes like me logo Genes that share expressions with WNT10B: view

Expression partners for WNT10B Gene

In Situ Assay Products

Orthologs for WNT10B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT10B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WNT10B 35
  • 91.92 (n)
  • 95.1 (a)
WNT10B 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT10B 35
  • 93.21 (n)
  • 97.88 (a)
mouse
(Mus musculus)
Mammalia Wnt10b 35
  • 90.16 (n)
  • 97.54 (a)
Wnt10b 16
Wnt10b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WNT10B 35
  • 99.06 (n)
  • 98.71 (a)
WNT10B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt10b 35
  • 90.44 (n)
  • 97.54 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia WNT10B 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt10b 35
  • 66.67 (n)
  • 71.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia wnt10-A 35
zebrafish
(Danio rerio)
Actinopterygii wnt10b 35
  • 66.39 (n)
  • 68.13 (a)
wnt10b 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt10 37
  • 42 (a)
Wnt10 35
  • 54.14 (n)
  • 47.63 (a)
Wnt10 36
  • 34 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009731 35
  • 45.97 (n)
  • 36.82 (a)
worm
(Caenorhabditis elegans)
Secernentea mom-2 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for WNT10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT10B Gene

ENSEMBL:
Gene Tree for WNT10B (if available)
TreeFam:
Gene Tree for WNT10B (if available)

Paralogs for WNT10B Gene

Paralogs for WNT10B Gene

Selected SIMAP similar genes for WNT10B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WNT10B: view

Variants for WNT10B Gene

Sequence variations from dbSNP and Humsavar for WNT10B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs767627 -- 48,969,784(-) CCCAG(G/T)CCTGG intron-variant
rs833834 -- 48,968,996(-) TCCCC(A/C)ACCTC intron-variant
rs833835 -- 48,967,367(-) ctaac(A/G)tggga intron-variant
rs833841 -- 48,972,055(+) GCCCA(A/G)ATGGC upstream-variant-2KB
rs833842 -- 48,971,640(-) CTCCC(G/T)CCCTT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for WNT10B Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV Gain 17160897

Relevant External Links for WNT10B Gene

HapMap Linkage Disequilibrium report
WNT10B
Human Gene Mutation Database (HGMD)
WNT10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT10B Gene

Disorders for WNT10B Gene

(1) OMIM Diseases for WNT10B Gene (601906)

UniProtKB/Swiss-Prot

WN10B_HUMAN
  • Split-hand/foot malformation 6 (SHFM6) [MIM:225300]: A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. {ECO:0000269 PubMed:18515319}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(10) Novoseek inferred disease relationships for WNT10B Gene

Disease -log(P) Hits PubMed IDs
mammary tumor 68.7 2
gastric cancer 41.8 3
pancreatic cancer 41.3 1
cervical cancer 37.9 2
breast cancer 31.3 2

Relevant External Links for WNT10B

Genetic Association Database (GAD)
WNT10B
Human Genome Epidemiology (HuGE) Navigator
WNT10B
Tumor Gene Database (TGDB):
WNT10B
genes like me logo Genes that share disorders with WNT10B: view

No data available for University of Copenhagen DISEASES and Genatlas for WNT10B Gene

Publications for WNT10B Gene

  1. A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas. (PMID: 9121776) Bui T.D. … Lindsay S. (Oncogene 1997) 2 3 4 23
  2. Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45. (PMID: 11713588) Saitoh T. … Katoh M. (Int. J. Oncol. 2001) 3 4 23
  3. Isolation, characterization and chromosomal localization of human WNT10B. (PMID: 9284937) Hardiman G. … Bazan J.F. (Cytogenet. Cell Genet. 1997) 2 3 4
  4. Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation. (PMID: 18515319) Ugur S.A. … Tolun A. (Hum. Mol. Genet. 2008) 2 3 4
  5. WNT10B mutations in human obesity. (PMID: 16477437) Christodoulides C. … Vettor R. (Diabetologia 2006) 3 4

Products for WNT10B Gene

Sources for WNT10B Gene

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