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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT10B Gene

protein-coding   GIFtS: 66
GCID: GC12M049359

Wingless-Type MMTV Integration Site Family, Member 10B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 10B1 2     WNT-10B Protein2
SHFM62 5     WNT123
WNT-122     Protein Wnt-123
Protein Wnt-10b2     

External Ids:    HGNC: 127751   Entrez Gene: 74802   Ensembl: ENSG000001698847   OMIM: 6019065   UniProtKB: O007443   

Export aliases for WNT10B gene to outside databases

Previous GC identifers: GC12P049449 GC12P049527 GC12M049075 GC12M047645 GC12M046390


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT10B Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in
breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is
96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family
member, WNT1, in the chromosome 12q13 region. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT10B Gene: 
WNT10B (wingless-type MMTV integration site family, member 10B) is a protein-coding gene. Diseases associated with WNT10B include skeletal muscle regeneration, and split-hand/foot malformation 6, and among its related super-pathways are Basal cell carcinoma and Wnt signaling pathway. GO annotations related to this gene include receptor agonist activity and G-protein coupled receptor binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters (By similarity)

Gene Wiki entry for WNT10B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT10B gene promoter:
         SREBP-1c   E2F-2   HNF-4alpha2   HNF-4alpha1   SREBP-1b   PPAR-gamma1   E2F   E2F-1   SREBP-1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT10B promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT10B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT10B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

WNT10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT10B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049359:  view genomic region     (about GC identifiers)

Start:
49,359,123 bp from pter      End:
49,365,641 bp from pter
Size:
6,519 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744 (See protein sequence)
Recommended Name: Protein Wnt-10b precursor  
Size: 389 amino acids; 43000 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Developmental stage: Infant brain has higher levels of WNT10B than adult brain
Secondary accessions: B2R7A5 O00747 Q4VAJ5 Q8WZ97

Explore the universe of human proteins at neXtProt for WNT10B: NX_O00744

Explore proteomics data for WNT10B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00744

  • WNT10B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WNT10B Protein Expression
    REFSEQ proteins: NP_003385.2  
    ENSEMBL proteins: 
     ENSP00000301061   ENSP00000384691   ENSP00000385980   ENSP00000398473   ENSP00000404896  
    Reactome Protein details: O00744
    Human Recombinant Protein Products for WNT10B: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT10B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space NAS15135146

    WNT10B for ontologies           About GeneDecksing



    WNT10B Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR005817 Wnt
     IPR013302 Wnt10
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry O00744

    ProtoNet protein and cluster: O00744

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744
    Similarity: Belongs to the Wnt family


    WNT10B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WN10B_HUMAN, O00744
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters (By similarity)

         Genatlas biochemistry entry for WNT10B:
    wingless-type MMTV integration site 10B,Drosophila wingless (Wg) segment polarity gene homolog,expressed in breast
    carcinoma,heart,skeletal muscle,modulating cell fate and cell behavior during vertebrate development

         Summary:
    During embryonic development, WNT10B as signaling molecule is secreted from the following cells: Primary Hair Placode Cells in Hair Follicle It affects the following cells: Immature Endochondral Osteoblasts in Zeugopod Periosteum, Immature Endochondral Osteoblasts in Lumbar Vertebrae (see all 9).

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
    GO:0048018receptor agonist activity IC17761539
         
    WNT10B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WNT10B:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Wnt10b):
     muscle 

    WNT10B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wnt10btm1Ptr for WNT10B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for WNT10B 
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    hsa-miR-4264 hsa-miR-3934 hsa-miR-148b hsa-miR-1260b hsa-miR-452* hsa-miR-1260 hsa-miR-152 hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidWNT10B 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WNT10B About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Basal cell carcinoma
    Hedgehog signaling pathway0.43
    Wnt Pathway0.39
    Basal cell carcinoma0.43
    Melanogenesis0.32
    2Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway0.40
    3Wnt Signaling Pathway
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    5Asparagine N-linked glycosylation
    WNT ligand biogenesis and trafficking0.77
    Signaling by Wnt0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for WNT10B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT10B
        Wnt Signaling Pathway

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT10B (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT10B
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT10B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for WNT10B
        Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency
    Adipogenesis

    5/6        Reactome Pathways for WNT10B (see all 6)
        Signaling by Wnt
    Signal Transduction
    Signaling by GPCR
    WNT ligand biogenesis and trafficking
    GPCR ligand binding


    5/8         Kegg Pathways  (Kegg details for WNT10B) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT10B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WNT10B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for WNT10B (ENSP000003010614) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADIPOQENSP000003207094STRING: ENSP00000320709
    CCNCENSP000003582224STRING: ENSP00000358222
    CEBPBENSP000003054224STRING: ENSP00000305422
    EBF1ENSP000003228984STRING: ENSP00000322898
    FABP4ENSP000002561044STRING: ENSP00000256104
    About this table

    Gene Ontology (GO): 5/43 biological process terms (GO ID links to tree view) (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IEA--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002062chondrocyte differentiation IEP15135146
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006629lipid metabolic process IEA--

    WNT10B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WNT10B for compounds           About GeneDecksing

    EMD Millipore small molecules for WNT10B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT10B (WN10B)

    2 Novoseek inferred chemical compound relationships for WNT10B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 25.6 1 12213737 (1)
    progesterone 14.3 1 12213737 (1)

    Search CenterWatch for drugs/clinical trials and news about WNT10B / WN10B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WNT10B gene: 
    NM_003394.3  

    Unigene Cluster for WNT10B:

    Wingless-type MMTV integration site family, member 10B
    Hs.91985  [show with all ESTs]
    Unigene Representative Sequence: NM_003394
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301061(uc001rss.3 uc001rst.3) ENST00000407467 ENST00000403957
    ENST00000413630 ENST00000475740 ENST00000420388
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    Additional mRNA sequence: 

    AB070724.1 AK312906.1 BC096353.3 BC096354.1 BC096356.1 U81787.1 X97057.1 

    6 DOTS entries:

    DT.213357  DT.121205165  DT.95156828  DT.75101700  DT.121010219  DT.453494 

    4 AceView cDNA sequences:

    AB070724 NM_003394 U81787 X97057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT10B expression in normal human tissues (normalized intensities)      WNT10B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCTTGGAG
    WNT10B Expression
    About this image


    WNT10B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Hair (Integumentary System)    fully expand to see all 4 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
             mouse/organ system/integumental system   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Ectoderm (Gastrulation Derivatives)
             Ectoderm Cells Branchial Arch 1
     
     Bone (Muscoskeletal System)
             Mandibular Process

    See WNT10B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT10B

    SOURCE GeneReport for Unigene cluster: Hs.91985

    UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744
    Tissue specificity: Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low
    levels are found in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT10B: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT10B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WNT10B gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt10b1 , 5 wingless related MMTV integration site 10b1, 5 90.15(n)1
    96.92(a)1
      15 (54.65 cM)5
    224101  NM_011718.21  NP_035848.11 
     987717535 
    lizard
    (Anolis carolinensis)
    Reptilia WNT10B6
    Protein Wnt
    59(a)
    1 ↔ 1
    2(94100765-94116887)
    African clawed frog
    (Xenopus laevis)
    Amphibia wnt10-A2 wnt-1 related (wnt-10), wingless-type MMTV integration more 73.64(n)    L07530.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt10b2 wingless-type MMTV integration site family, member more 76.74(n)   30308  AY182171.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wnt101 , 3 frizzled-2 receptor signaling pathway
    signal transducer3
    CG4971-PB1
    42(a)3
    52.06(n)1
    45.67(a)1
      27F33
    340111  NM_135265.31  NP_609109.31 


    ENSEMBL Gene Tree for WNT10B (if available)
    TreeFam Gene Tree for WNT10B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT10B gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  
    WNT12  WNT42  WNT7A2  WNT7B2  WNT32  WNT10A2  
    13 SIMAP similar genes for WNT10B using alignment to 5 protein entries:     WN10B_HUMAN (see all proteins):
    WNT10A    WNT4    WNT2    WNT7B    WNT7A    WNT5B
    WNT5A    WNT6    WNT1    WNT3A    WNT2B    WNT11
    WNT3

    WNT10B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/187 SNPs in WNT10B are shown (see all 187)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0625164
    Split-hand/foot malformation 6 (SHFM6)4--see VAR_0625162 R W mis40--------
    VAR_0625144
    ----see VAR_0625142 I T mis40--------
    VAR_0625134
    ----see VAR_0625132 C Y mis40--------
    rs724053191,2
    C--46397213(+) TCCCA-/GCGC  
            
    GCGCG
    1 -- ut510--------
    rs1380877451,2
    C--49191647(+) ATGAAG/TTTTTA 1 -- ds50010--------
    rs1410113161,2
    C--49191661(+) GACACA/GGCCAC 1 -- ds50010--------
    rs1845821181,2
    --49191667(+) GCCACA/GCTCAT 1 -- ds50010--------
    rs1905861121,2
    --49191699(+) CTGCTA/GTTGAT 1 -- ds50010--------
    rs1140640081,2
    F--49191829(+) GTTCTA/GAGGCA 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs37823531,2
    C,F,A,H--49191864(+) GAGGCG/ACATAG 1 -- ds5001109Minor allele frequency- A:0.38EA NS NA PA EU CA WA CSA 8340

    HapMap Linkage Disequilibrium report for WNT10B (49359123 - 49365641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WNT10B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832404CNV Gain17160897


    Human Gene Mutation Database (HGMD): WNT10B
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT10B
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT10B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601906   
    OMIM disorders: 225300  
    UniProtKB/Swiss-Prot: WN10B_HUMAN, O00744
  • Split-hand/foot malformation 6 (SHFM6) [MIM:225300]: A limb malformation involving the central rays of
    the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of
    the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal
    and craniofacial findings, and orofacial clefting. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 16 diseases for WNT10B:    About MalaCards
    skeletal muscle regeneration    split-hand/foot malformation 6    split hand    split hand foot malformation
    syndactyly    basal cell carcinoma    breast cancer    gastric cancer
    endometrial carcinoma    neuroblastoma    osteosarcoma    obesity
    pancreatic cancer    colorectal cancer    ovarian cancer    pancreatitis


    WNT10B for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for WNT10B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mammary tumor 68.7 2 8738604 (1), 12429977 (1)
    gastric cancer 41.8 3 12239602 (2), 11713588 (1)
    pancreatic cancer 41.3 1 12239602 (1)
    cervical cancer 37.9 2 12239602 (2)
    breast cancer 31.3 3 12239602 (1), 9121776 (1)
    cancer 25 5 12239602 (2), 9121776 (1)
    necrosis 15.5 1 12239602 (1)
    tumors 14.3 3 12213737 (1), 12239602 (1)
    carcinoma squamous cell 12.2 1 12239602 (1)
    carcinoma 0 2 9121776 (1), 15300008 (1)

    Genetic Association Database (GAD): WNT10B
    Human Genome Epidemiology (HuGE) Navigator: WNT10B (10 documents)
    Tumor Gene Database (TGDB): WNT10B

    Export disorders for WNT10B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT10B gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with WNT10B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas. (PubMed id 9121776)1, 2, 3, 9 Bui T.D.... Lindsay S. (1997)
    2. Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation. (PubMed id 18515319)1, 2, 3 Ugur S.A. and Tolun A. (2008)
    3. Isolation, characterization and chromosomal localization of human WNT10B. (PubMed id 9284937)1, 2, 3 Hardiman G.... Bazan J.F. (1997)
    4. Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45. (PubMed id 11713588)1, 2, 9 Saitoh T.... Katoh M. (2001)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Polymorphisms of the WNT10B gene, bone mineral densit y, and fractures in postmenopausal women. (PubMed id 19458884)1, 4 Perez-Castrillon J.L....Riancho J.A. (2009)
    8. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    9. Association Analysis of WNT10B with Bone Mass and Structure Among Individuals of African Ancestry. (PubMed id 19016593)1, 4 Zmuda J.M....Ferrell R.E. (2008)
    10. WNT10B mutations in human obesity. (PubMed id 16477437)1, 2 Christodoulides C.... Vettor R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7480 HGNC: 12775 AceView: WNT10B Ensembl:ENSG00000169884 euGenes: HUgn7480
    ECgene: WNT10B Kegg: 7480 H-InvDB: WNT10B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT10B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT10B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WNT10B gene:
    Search GeneIP for patents involving WNT10B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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