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WNT10A Gene

protein-coding   GIFtS: 63
GCID: GC02P219745

Wingless-Type MMTV Integration Site Family, Member 10A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 10A1 2
OODD2 5
SSPS2 5
STHAG42 5
Protein Wnt-10a2

External Ids:    HGNC: 138291   Entrez Gene: 803262   Ensembl: ENSG000001359257   OMIM: 6062685   UniProtKB: Q9GZT53   

Export aliases for WNT10A gene to outside databases

Previous GC identifers: GC02P217761 GC02P218466 GC02P219709 GC02P219947 GC02P219570 GC02P219453 GC02P211599


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT10A Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed
in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member,
the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key
roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6
gene are clustered in the chromosome 2q35 region. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT10A Gene:
WNT10A (wingless-type MMTV integration site family, member 10A) is a protein-coding gene. Diseases associated with WNT10A include hidrocystoma, and odontoonychodermal dysplasia. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT8B.

UniProtKB/Swiss-Prot: WN10A_HUMAN, Q9GZT5
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell
diameters

Gene Wiki entry for WNT10A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT10A gene promoter:
         PPAR-gamma1   COMP1   Lmo2   MyoD   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT10A promoter sequence
   Search Chromatin IP Primers for WNT10A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT10A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

WNT10A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT10A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219745:  view genomic region     (about GC identifiers)

Start:
219,745,085 bp from pter      End:
219,764,303 bp from pter
Size:
19,219 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WN10A_HUMAN, Q9GZT5 (See protein sequence)
Recommended Name: Protein Wnt-10a precursor  
Size: 417 amino acids; 46444 Da
Secondary accessions: Q53S44 Q96TA7 Q9H7S8

Explore the universe of human proteins at neXtProt for WNT10A: NX_Q9GZT5

Explore proteomics data for WNT10A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn106, Asn363

  • See WNT10A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079492.2  
    ENSEMBL proteins: 
     ENSP00000258411   ENSP00000388812  
    Reactome Protein details: Q9GZT5

    WNT10A Human Recombinant Protein Products:

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    WNT10A Antibody Products:

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    Cloud-Clone Corp. CLIAs for WNT10A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR005817 Wnt
     IPR013302 Wnt10
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q9GZT5

    ProtoNet protein and cluster: Q9GZT5

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WN10A_HUMAN, Q9GZT5
    Similarity: Belongs to the Wnt family


    WNT10A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WN10A_HUMAN, Q9GZT5
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell
    diameters

         Summary: 

    During embryonic development, WNT10A as signaling molecule is secreted from the following cells:
                
    Hair: Primary Hair Placode Cells (Hair Follicle)

    It affects the following cells:
    Hair: Primary Hair Placode Cells (Hair Follicle)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
         
    WNT10A for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Wnt10a (no phenotypes)

    WNT10A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT10A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT10A
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    miRNA
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    Block miRNA regulation of human, mouse, rat WNT10A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WNT10A (see all 14):
    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-378b hsa-miR-422a hsa-miR-4295 hsa-miR-454 hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidWNT10A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WNT10A
    Predesigned siRNA for gene silencing in human, mouse, rat WNT10A

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    GenScript: all cDNA clones in your preferred vector: WNT10A (NM_025216)
    Sino Biological Human cDNA Clone for WNT10A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT10A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT10A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WN10A_HUMAN, Q9GZT5: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    golgi apparatus2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--

    WNT10A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT10A About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT10A
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT10A (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT10A
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT10A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for WNT10A
        Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency

    2 Sino Biological Pathways for WNT10A
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    2 Reactome Pathways for WNT10A
        WNT ligand biogenesis and trafficking
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT10A) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT10A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT10A: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT10A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT10A (ENSP000002584114) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD10ENSP000002290304STRING: ENSP00000229030
    FZD2ENSP000003239014STRING: ENSP00000323901
    FZD3ENSP000002400934STRING: ENSP00000240093
    FZD5ENSP000003546074STRING: ENSP00000354607
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IMP17847007
    GO:0007275multicellular organismal development ----
    GO:0010628positive regulation of gene expression IEA--
    GO:0014033neural crest cell differentiation IEA--
    GO:0016055Wnt signaling pathway IBA--

    WNT10A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT10A (WN10A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WNT10A gene: 
    NM_025216.2  

    Unigene Cluster for WNT10A:

    Wingless-type MMTV integration site family, member 10A
    Hs.121540  [show with all ESTs]
    Unigene Representative Sequence: BC052234
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258411(uc002vjd.1) ENST00000458582 ENST00000483911 ENST00000489887

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WNT10A (see all 14):
    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-378b hsa-miR-422a hsa-miR-4295 hsa-miR-454 hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidWNT10A 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat WNT10A
      QuantiFast Probe-based Assays in human, mouse, rat WNT10A

    Additional mRNA sequence: 

    AB059569.1 AK024363.1 AK315081.1 AY009400.1 BC003544.1 BC034352.1 BC040026.1 BC052234.1 

    3 DOTS entries:

    DT.454447  DT.95368361  DT.95368360 

    Selected AceView cDNA sequences (see all 40):

    BM763448 BM919884 NM_025216 BC052234 AK024363 BC003544 BC034352 BC040026 
    AI568838 AB059569 BM847064 BM846982 AU140067 BQ188660 AY009400 BX390882 
    AA812250 AI609335 BG679501 BM929535 AI810560 BM919543 BX384828 BM718957 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WNT10A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:              -                           
    SP2:              -     -     -               
    SP3:                                          


    ECgene alternative splicing isoforms for WNT10A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT10A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAATAAAC
    WNT10A Expression
    About this image


    WNT10A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 5 entries
             Secondary Enamel Knot Cells Enamel Knot
             Dental Papilla
     
     Epithelial Cells
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Dermal Condensate Cells Dermal Papilla
             Dental Papilla
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    WNT10A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT10A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121540
        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT10A: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat WNT10A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT10A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WNT10A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt10a1 , 5 wingless related MMTV integration site 10a1, 5 89.05(n)1
    95.2(a)1
      1 (38.54 cM)5
    224091  NM_009518.21  NP_033544.11 
     747915165 
    chicken
    (Gallus gallus)
    Aves WNT10A1 wingless-type MMTV integration site family, member more 79.82(n)
    83.24(a)
      429040  NM_001006590.1  NP_001006590.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT10A6
    wingless-type MMTV integration site family, member...
    78(a)
    1 ↔ 1
    6(34120486-34142628)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wnt10a1 wingless-type MMTV integration site family, member more 74.46(n)
    79.89(a)
      100485724  XM_002933958.2  XP_002934004.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt10a2 wnt10a 78.15(n)   30171  U02544.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wnt103 frizzled-2 receptor signaling pathway
    signal transducer
    45(a)   27F3   --
    worm
    (Caenorhabditis elegans)
    Secernentea egl-206
    Protein EGL-20 (egl-20) mRNA, complete cds
    31(a)
    many ↔ many
    IV(9812444-9815526) WBGene00001188


    ENSEMBL Gene Tree for WNT10A (if available)
    TreeFam Gene Tree for WNT10A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT10A gene
    WNT8B2  WNT10B2  WNT8A2  WNT9B2  WNT9A2  
    10 SIMAP similar genes for WNT10A using alignment to 3 protein entries:     WN10A_HUMAN (see all proteins):
    WNT10B    WNT4    WNT2    WNT3    WNT6    WNT7A
    WNT7B    WNT2B    WNT3A    WNT1

    WNT10A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WNT10A (see all 308)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219081201,2,,4
    C,FTooth agenesis selective 4 (STHAG4)4 pathogenic1225109959(+) AGGACT/ATTCTG 2 /I /F mis12Minor allele frequency- A:0.02NA EU 4279
    rs1469021561,2,,4
    C,FTooth agenesis selective 4 (STHAG4)4 pathogenic1225109992(+) GCCCCG/AACATG 2 /N /D mis11Minor allele frequency- A:0.00NA 3826
    rs1219081211,2,,4
    CTooth agenesis selective 4 (STHAG4)4 pathogenic1225110258(+) TTTCCA/GAGAGA 2 Q R mis10--------
    rs1219081191,2
    C,Fpathogenic1225117953(+) AACTGC/ATCAAG 2 /* /C stg11Minor allele frequency- A:0.00NA 4552
    rs1819494541,2
    --211597769(+) GCAGCA/GTTTCC 1 -- us2k10--------
    rs1842177201,2
    --211597771(+) AGCGTG/TTCCCA 1 -- us2k10--------
    rs1502706981,2
    --211597781(+) AAAAGA/GAGTCC 1 -- us2k10--------
    rs1387479561,2
    --211598041(+) AACAGC/TCAATA 1 -- us2k10--------
    rs38065571,2
    C,F,A,H--211598381(+) TGAGGG/AGGAAA 1 -- us2k1 trp319Minor allele frequency- A:0.42NS EA NA CSA WA 2341
    rs1903682401,2
    --211598390(+) AAGGAA/GGGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT10A (219745085 - 219764303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WNT10A:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4436n71CNV Loss21882294
    nsv875864CNV Loss21882294
    nsv875867CNV Loss21882294
    nsv834542CNV Gain17160897

    Human Gene Mutation Database (HGMD): WNT10A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT10A
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT10A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606268   
    OMIM disorders: 257980  224750  150400  
    UniProtKB/Swiss-Prot: WN10A_HUMAN, Q9GZT5
  • Note=Defects in WNT10A may be a cause of hypohidrotic/anhidrotic ectodermal dysplasia, a disorder
    characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat
    due to the absence of sweat glands. Most patients carrying WNT10A mutations present with sweating anomalies.
    However, comparison with cases harboring mutations in the ectodysplasin pathway identifies some phenotypic
    differences. Dermatological features (anomalies of hair and sweat glands) are less severe in patients carrying
    WNT10A mutations and facial dysmorphism can be absent. The dental phenotype consists in microdontia, whereas
    teeth agenesis is more frequent in patients carrying mutations in the ectodysplasin pathway
  • Odonto-onycho-dermal dysplasia (OODD) [MIM:257980]: A rare autosomal recessive ectodermal dysplasia
    characterized by dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform
    papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Schopf-Schulz-Passarge syndrome (SSPS) [MIM:224750]: A rare ectodermal dysplasia, characterized chiefly
    by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple
    eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in adulthood. The
    concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some
    affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage
    neoplasms. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Tooth agenesis selective 4 (STHAG4) [MIM:150400]: A form of selective tooth agenesis, a common anomaly
    characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated
    systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more
    permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not
    include absence of third molars (wisdom teeth). In STHAG4, the upper lateral incisors are absent or peg-shaped.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for WNT10A (see all 26):    
    About MalaCards
    hidrocystoma    odontoonychodermal dysplasia    extratemporal epilepsy    tooth agenesis, selective, 4
    schopf-schulz-passarge syndrome    ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive    burkitt's lymphoma    alexithymia
    social phobia    tooth agenesis, selective, 1, with or without orofacial cleft    tooth agenesis    pneumothorax
    colorectal cancer    mantle cell lymphoma    hypotrichosis    ectodermal dysplasia
    keratoderma    basal cell carcinoma    alopecia    leukemia

    2 diseases from the University of Copenhagen DISEASES database for WNT10A:
    Alexithymia     Extratemporal epilepsy

    WNT10A for disorders           About GeneDecksing

    Genetic Association Database (GAD): WNT10A
    Human Genome Epidemiology (HuGE) Navigator: WNT10A (4 documents)

    Export disorders for WNT10A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for WNT10A gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with WNT10A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. (PubMed id 17847007)1, 2, 3 Adaimy L.... Megarbane A. (Am. J. Hum. Genet. 2007)
    2. WNT10A and WNT6, clustered in human chromosome 2q35 region with head- to-tail manner, are strongly co-expressed in SW480 cells. (PubMed id 11350055)1, 2, 3 Kirikoshi H.... Katoh M. (Biochem. Biophys. Res. Commun. 2001)
    3. Mutations in WNT10A are present in more than half of isolated hypodontia cases. (PubMed id 22581971)1, 2 van den Boogaard M.J.... Ploos van Amstel H.K. (J. Med. Genet. 2012)
    4. Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases. (PubMed id 20979233)1, 2 Cluzeau C.... Smahi A. (Hum. Mutat. 2011)
    5. Web-based, participant-driven studies yield novel genetic associations for common traits. (PubMed id 20585627)1, 4 Eriksson N....Mountain J. (PLoS Genet. 2010)
    6. WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes. (PubMed id 19559398)1, 2 Bohring A.... Ropke A. (Am. J. Hum. Genet. 2009)
    7. Common variants in the trichohyalin gene are associated with straight hair in Europeans. (PubMed id 19896111)1, 4 Medland S.E....Martin N.G. (Am. J. Hum. Genet. 2009)
    8. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    9. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PubMed id 16953426)1, 4 Beaty T.H....Scott A.F. (Hum. Genet. 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 80326 HGNC: 13829 AceView: WNT10A Ensembl:ENSG00000135925 euGenes: HUgn80326
    ECgene: WNT10A Kegg: 80326 H-InvDB: WNT10A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WNT10A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT10A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT10A gene:
    Search GeneIP for patents involving WNT10A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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