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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT10A Gene

protein-coding   GIFtS: 62
GCID: GC02P219745

wingless-type MMTV integration site family, member 10A

 Explore 20 diseases affiliated with
WNT10A via our new
 Human Malady Compendium 
Biological research products
for WNT10A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 10A1 2
SSPS2 5
OODD2
STHAG42
Protein Wnt-10a2

External Ids:    HGNC: 138291   Entrez Gene: 803262   Ensembl: ENSG000001359257   OMIM: 6062685   UniProtKB: Q9GZT53   

Export aliases for WNT10A gene to outside databases

Previous GC identifers: GC02P217761 GC02P218466 GC02P219709 GC02P219947 GC02P219570 GC02P219453 GC02P211599


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT10A:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins
have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and
patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell
lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are
strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis
through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the
chromosome 2q35 region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WN10A_HUMAN, Q9GZT5
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters

Gene Wiki entry for WNT10A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT10A gene promoter:
         PPAR-gamma1   COMP1   Lmo2   MyoD   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT10A promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT10A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT10A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

WNT10A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT10A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219745:  view genomic region     (about GC identifiers)

Start:
219,745,085 bp from pter      End:
219,764,303 bp from pter
Size:
19,219 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WN10A_HUMAN, Q9GZT5 (See protein sequence)
Recommended Name: Protein Wnt-10a precursor  
Size: 417 amino acids; 46444 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q53S44 Q96TA7 Q9H7S8

Explore the universe of human proteins at neXtProt for WNT10A: NX_Q9GZT5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9GZT5

  • WNT10A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079492.2  
    ENSEMBL proteins: 
     ENSP00000258411   ENSP00000388812  
    Reactome Protein details: Q9GZT5
    Human Recombinant Protein Products: 
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    Novus Biologicals WNT10A Protein
    Novus Biologicals WNT10A Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WNT10A

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--
    GO:0005886plasma membrane IBA--


    WNT10A for ontologies           About GeneDecksing



    WNT10A Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    WNT10A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005817 Wnt
     IPR013302 Wnt10
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q9GZT5

    ProtoNet protein and cluster: Q9GZT5

    1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WN10A_HUMAN, Q9GZT5
    Similarity: Belongs to the Wnt family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: WN10A_HUMAN, Q9GZT5
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
    May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT10A (see all 14):
    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-378b hsa-miR-422a hsa-miR-4295 hsa-miR-454 hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidWNT10A 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT10A

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--


    WNT10A for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    Wnt Signaling Pathway1.00
    Wnt Signaling Pathway0.33
    Wnt Signaling Pathway and Pluripotency0.55
    Wnt signaling pathway0.30
    DNA damage response (only ATM dependent)0.35
    2Basal cell carcinoma
    Basal cell carcinoma1.00
    Wnt Pathway0.37
    Hedgehog signaling pathway0.41
    Melanogenesis0.32
    3Translation_Non-genomic (rapid) action of Androgen Receptor
    Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    Translation Non-genomic (rapid) action of Androgen Receptor0.99
    4Transcription_Androgen Receptor nuclear signaling
    Transcription_Androgen Receptor nuclear signaling1.00
    Transcription Androgen Receptor nuclear signaling0.99
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency1.00
    GSK3 Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for WNT10A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT10A
        Wnt Signaling Pathway

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT10A (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT10A
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT10A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for WNT10A 
        DNA damage response (only ATM dependent)
    Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency

    4        Reactome Pathways for WNT10A
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    5         Kegg Pathways  (Kegg details for WNT10A):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    WNT10A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WNT10A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for WNT10A (ENSP000002584114) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD10ENSP000002290304STRING: ENSP00000229030
    FZD2ENSP000003239014STRING: ENSP00000323901
    FZD3ENSP000002400934STRING: ENSP00000240093
    FZD5ENSP000003546074STRING: ENSP00000354607
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IMP19559398
    GO:0008585female gonad development IBA--
    GO:0009798axis specification IBA--
    GO:0009952anterior/posterior pattern specification IBA--
    GO:0010628positive regulation of gene expression IEA--


    WNT10A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for WNT10A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT10A
    Search CenterWatch for drugs/clinical trials and news about WNT10A / WN10A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WNT10A gene: 
    NM_025216.2  

    Unigene Cluster for WNT10A:

    Wingless-type MMTV integration site family, member 10A
    Hs.121540  [show with all ESTs]
    Unigene Representative Sequence: BC052234
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258411(uc002vjd.1) ENST00000458582 ENST00000483911 ENST00000489887


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    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-378b hsa-miR-422a hsa-miR-4295 hsa-miR-454 hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidWNT10A 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT10A (see all 3)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT10A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT10A

    Additional cDNA sequence: 

    AB059569.1 AK024363.1 AK315081.1 AY009400.1 BC003544.1 BC034352.1 BC040026.1 BC052234.1 

    3 DOTS entries:

    DT.454447  DT.95368361  DT.95368360 

    24/40 AceView cDNA sequences (see all 40):

    AK024363 NM_025216 BM919884 BM763448 AB059569 BC052234 BC003544 BC040026 
    AI568838 BC034352 BM919543 AI609335 AY009400 BQ188660 AI810560 BG679501 
    AA812250 BM846982 BX384828 BX390882 AU140067 BM847064 BM929535 BM718957 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WNT10A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:              -                           
    SP2:              -     -     -               
    SP3:                                          


    ECgene alternative splicing isoforms for WNT10A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT10A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCAATAAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See WNT10A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT10A

    SOURCE GeneReport for Unigene cluster: Hs.121540
        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT10A: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT10A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WNT10A gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves WNT10A1 wingless-type MMTV integration site family, member more 79.43(n)
    82.98(a)
      429040  NM_001006590.1  NP_001006590.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT10A6
    --
    78(a)
    1 ↔ 1
    6(34120486-34141898)
    zebrafish
    (Danio rerio)
    Actinopterygii wnt10a2 wnt10a 78.15(n)   30171  U02544.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wnt103 frizzled-2 receptor signaling pathway signal
    transducer
    45(a)   27F3   --
    worm
    (Caenorhabditis elegans)
    Secernentea mom-26
    Protein mom-2
    29(a)
    1 → many
    V(8355968-8358168)


    ENSEMBL Gene Tree for WNT10A (if available)
    TreeFam Gene Tree for WNT10A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT10A gene
    WNT5B2  WNT162  WNT5A2  WNT62  WNT112  WNT22  WNT2B2  WNT3A2  
    WNT12  WNT10B2  WNT42  WNT7A2  WNT7B2  WNT32  
    13 SIMAP similar genes for WNT10A using alignment to 3 protein entries:     WN10A_HUMAN (see all proteins):
    WNT10B    WNT4    WNT2    WNT3    WNT6    WNT7A
    WNT7B    WNT2B    WNT3A    WNT1    WNT5A    WNT9A
    WNT5B

    WNT10A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/224 NCBI SNPs in WNT10A are shown (see all 224    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219081201,2
    C,F,pathogenic225109959(+) AGGACT/ATTCTG 2 /I /F mis12Minor allele frequency- A:0.02NA EU 4279
    rs1219081191,2
    C,Fpathogenic225117953(+) AACTGC/ATCAAG 2 /* /C stg11Minor allele frequency- A:0.00NA 4552
    rs730847591,2
    C,--211598558(+) CCTAAG/ACCAGC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs774309041,2
    F,--211598866(+) GACCAT/CGTGCA 1 -- us2k11Minor allele frequency- C:0.12WA 118
    rs730847601,2
    C,--211598906(+) TGAGAG/ATATCT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs794478561,2
    C,F,--211599113(+) CTCCTC/ACCAGG 1 -- us2k11Minor allele frequency- A:0.17WA 118
    rs774208741,2
    F,--211599337(+) CCACAC/TCTGCC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs784891601,2
    --211600589(+) TGTGTG/AGGGGG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1132242001,2
    --211600590(+) GTGTGG/TGGGGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs730847631,2
    C,F,--211601133(+) GCCACA/GAGCAT 1 -- int13Minor allele frequency- G:0.05WA 122

    HapMap Linkage Disequilibrium report for WNT10A (219745085 - 219764303 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for WNT10A: --
    Human Gene Mutation Database (HGMD): WNT10A

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    WNT10A for disorders           About GeneDecksing

    OMIM gene information: 606268   
    OMIM disorders: 257980  224750  
    UniProtKB/Swiss-Prot: WN10A_HUMAN, Q9GZT5
  • Note=Defects in WNT10A may be a cause of hypohidrotic/anhidrotic ectodermal dysplasia, a disorder
  • characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due
    to the absence of sweat glands. Most patients carrying WNT10A mutations present with sweating anomalies. However,
    comparison with cases harboring mutations in the ectodysplasin pathway identifies some phenotypic differences.
    Dermatological features (anomalies of hair and sweat glands) are less severe in patients carrying WNT10A mutations and
    facial dysmorphism can be absent. The dental phenotype consists in microdontia, whereas teeth agenesis is more
    frequent in patients carrying mutations in the ectodysplasin pathway
  • Defects in WNT10A are a cause of odonto-onycho-dermal dysplasia (OODD) [MIM:257980]. OODD is a rare autosomal
  • recessive ectodermal dysplasia in which the presenting phenotype is dry hair, severe hypodontia, smooth tongue with
    marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and
    soles, and hyperkeratosis of the skin
  • Defects in WNT10A are a cause of Schopf-Schulz-Passarge syndrome (SSPS) [MIM:224750]. SSPS is rare ectodermal
  • dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis
    and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually
    appear in adulthood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal
    skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin
    appendage neoplasms

    20 diseases for WNT10A:    About MalaCards
    schopf-schulz-passarge syndrome    burkitt's lymphoma    social phobia    odontoonychodermal dysplasia
    leukemia    extratemporal epilepsy    phobia    colorectal cancer
    ectodermal dysplasia    hidrocystoma    mantle cell lymphoma    hypodontia
    basal cell carcinoma    chronic lymphocytic leukemia    hypotrichosis    pneumothorax
    lymphocytic leukemia    keratoderma    hermaphroditism    carcinoma

    1 disease from the University of Copenhagen DISEASES database for WNT10A:
    Alexithymia
    Human Genome Epidemiology (HuGE) Navigator: WNT10A (4 documents)

    Export disorders for WNT10A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT10A gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with WNT10A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. (PubMed id 17847007)1, 2, 3 Adaimy L.... Megarbane A. (2007)
    2. WNT10A and WNT6, clustered in human chromosome 2q35 region with head- to-tail manner, are strongly co-expressed in SW480 cells. (PubMed id 11350055)1, 2, 3 Kirikoshi H.... Katoh M. (2001)
    3. Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases. (PubMed id 20979233)1, 2 Cluzeau C.... Smahi A. (2011)
    4. WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes. (PubMed id 19559398)1, 2 Bohring A.... Ropke A. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Mutations in WNT10A are present in more than half of i solated hypodontia cases. (PubMed id 22581971)1 van den Boogaard M.J....Ploos van Amstel H.K. (2012)
    8. Polymorphisms in WNT6 and WNT10A and colorectal adeno ma risk. (PubMed id 21547848)1 Galbraith R.L....Ulrich C.M. (2011)
    9. Intra-familial variability of ectodermal defects asso ciated with WNT10A mutations. (PubMed id 21279306)1 Wedgeworth E.K....McGrath J.A. (2011)
    10. Two families confirm SchAPpf-Schulz-Passarge syndrome as a discrete entity within the WNT10A phenotypic spectrum. (PubMed id 21143469)1 Castori M....Zambruno G. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80326 HGNC: 13829 AceView: WNT10A Ensembl:ENSG00000135925 euGenes: HUgn80326
    ECgene: WNT10A Kegg: 80326 H-InvDB: WNT10A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT10A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT10A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WNT10A gene:
    Search GeneIP for patents involving WNT10A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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