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Aliases for WNT1 Gene

Aliases for WNT1 Gene

  • Wingless-Type MMTV Integration Site Family, Member 1 2 3
  • INT1 3 4 6
  • Proto-Oncogene Int-1 Homolog 3 4
  • BMND16 3 6
  • OI15 3 6
  • Wingless-Type MMTV Integration Site Family, Member 1 (Oncogene INT1) 3
  • Proto-Oncogene Wnt-1 3

External Ids for WNT1 Gene

Previous Symbols for WNT1 Gene

  • INT1

Summaries for WNT1 Gene

Entrez Gene Summary for WNT1 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT1 Gene

WNT1 (Wingless-Type MMTV Integration Site Family, Member 1) is a Protein Coding gene. Diseases associated with WNT1 include idiopathic juvenile osteoporosis and osteogenesis imperfecta, type xv. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include transcription regulatory region DNA binding and protein domain specific binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot for WNT1 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.

Gene Wiki entry for WNT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT1 Gene

Genomics for WNT1 Gene

Genomic Location for WNT1 Gene

Start:
48,978,453 bp from pter
End:
48,982,613 bp from pter
Size:
4,161 bases
Orientation:
Plus strand

Genomic View for WNT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT1 Gene

Proteins for WNT1 Gene

  • Protein details for WNT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04628-WNT1_HUMAN
    Recommended name:
    Proto-oncogene Wnt-1
    Protein Accession:
    P04628
    Secondary Accessions:
    • Q5U0N2

    Protein attributes for WNT1 Gene

    Size:
    370 amino acids
    Molecular mass:
    40982 Da
    Quaternary structure:
    • Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3 (By similarity). Interacts with WLS (By similarity).

neXtProt entry for WNT1 Gene

Proteomics data for WNT1 Gene at MOPED

Post-translational modifications for WNT1 Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Palmitoleylation is necessary for proper trafficking to cell surface (Probable). Depalmitoleylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).
  • Glycosylation at Asn29, Asn316, Asn346, and Asn359

Other Protein References for WNT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT1 Gene

Domains for WNT1 Gene

Gene Families for WNT1 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT1 Gene

UniProtKB/Swiss-Prot:

WNT1_HUMAN
Family:
  • Belongs to the Wnt family.:
    • P04628
genes like me logo Genes that share domains with WNT1: view

Function for WNT1 Gene

Molecular function for WNT1 Gene

GENATLAS Biochemistry: wingless-type MMTV integration site 1,Drosophila wingless (wg),segment polarity gene homolog,modulating cell fate and cell behavior during vertebrate development e
UniProtKB/Swiss-Prot Function: Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.

Gene Ontology (GO) - Molecular Function for WNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005109 frizzled binding IC 19756656
GO:0005125 cytokine activity ISS --
GO:0005515 protein binding --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with WNT1: view
genes like me logo Genes that share phenotypes with WNT1: view

Animal Models for WNT1 Gene

MGI Knock Outs for WNT1:

miRNA for WNT1 Gene

miRTarBase miRNAs that target WNT1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WNT1 Gene

Localization for WNT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT1 Gene COMPARTMENTS Subcellular localization image for WNT1 gene
Compartment Confidence
extracellular 5
endosome 3
plasma membrane 3
nucleus 2
cytoskeleton 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for WNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IDA 11793365
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with WNT1: view

Pathways for WNT1 Gene

genes like me logo Genes that share pathways with WNT1: view

Gene Ontology (GO) - Biological Process for WNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000578 embryonic axis specification ISS --
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007267 cell-cell signaling ISS --
GO:0007275 multicellular organismal development --
genes like me logo Genes that share ontologies with WNT1: view

Compounds for WNT1 Gene

(10) Novoseek inferred chemical compound relationships for WNT1 Gene

Compound -log(P) Hits PubMed IDs
glycogen 47.8 6
lithium 34.2 2
retinoic acid 24.2 9
oligonucleotide 0 1
progesterone 0 2
genes like me logo Genes that share compounds with WNT1: view

Transcripts for WNT1 Gene

mRNA/cDNA for WNT1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT1 Gene

Wingless-type MMTV integration site family, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WNT1 Gene

No ASD Table

Relevant External Links for WNT1 Gene

GeneLoc Exon Structure for
WNT1
ECgene alternative splicing isoforms for
WNT1

Expression for WNT1 Gene

mRNA expression in normal human tissues for WNT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (11.5), Brain - Putamen (basal ganglia) (5.7), Brain - Cortex (4.8), and Brain - Caudate (basal ganglia) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WNT1 Gene

SOURCE GeneReport for Unigene cluster for WNT1 Gene Hs.248164

genes like me logo Genes that share expressions with WNT1: view

Orthologs for WNT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT1 36
  • 99.73 (n)
  • 100 (a)
WNT1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT1 36
  • 92.97 (n)
  • 98.65 (a)
WNT1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT1 36
  • 93.33 (n)
  • 98.92 (a)
WNT1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt1 36
  • 91.53 (n)
  • 98.92 (a)
Wnt1 16
Wnt1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT1 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt1 36
  • 91.17 (n)
  • 98.65 (a)
chicken
(Gallus gallus)
Aves WNT11B 37
  • 33 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia WNT1 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491444 36
  • 68.42 (n)
  • 74.56 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt1 36
  • 71.64 (n)
  • 79.53 (a)
wnt1 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009734 36
  • 64.04 (n)
  • 61.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta wg 36
  • 62.08 (n)
  • 60.78 (a)
wg 37
  • 44 (a)
OneToOne
wg 38
  • 58 (a)
Wnt5 38
  • 47 (a)
Wnt6 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-1 37
  • 36 (a)
OneToMany
lin-44 38
  • 29 (a)
mom-2 38
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
ManyToMany
Species with no ortholog for WNT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT1 Gene

ENSEMBL:
Gene Tree for WNT1 (if available)
TreeFam:
Gene Tree for WNT1 (if available)

Paralogs for WNT1 Gene

Paralogs for WNT1 Gene

Selected SIMAP similar genes for WNT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WNT1: view

Variants for WNT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for WNT1 Gene

P04628-WNT1_HUMAN
Genetic variations in WNT1 define the bone mineral density quantitative trait locus 16 (BMND16) [MIM:615221]. Variance in bone mineral density influences bone mass, contributes to size determination in the general population, and is a susceptibility factor for osteoporotic fractures.

Sequence variations from dbSNP and Humsavar for WNT1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs12830005 -- 48,981,893(+) GGAGA(A/C)CCCTT utr-variant-3-prime
rs60255525 -- 48,982,842(+) ACCTG(A/G)TCAGT downstream-variant-500B
rs75357001 -- 48,982,433(+) AACCC(A/G)ATCCC utr-variant-3-prime
rs76398454 -- 48,982,396(+) GGGTC(A/C)CAGCC utr-variant-3-prime
rs79565269 -- 48,981,659(+) CTCGC(C/T)CCCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WNT1 Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV Gain 17160897

Relevant External Links for WNT1 Gene

HapMap Linkage Disequilibrium report
WNT1
Human Gene Mutation Database (HGMD)
WNT1

Disorders for WNT1 Gene

(2) OMIM Diseases for WNT1 Gene (164820)

UniProtKB/Swiss-Prot

WNT1_HUMAN
  • Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. {ECO:0000269 PubMed:23499309, ECO:0000269 PubMed:23656646}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Osteogenesis imperfecta 15 (OI15) [MIM:615220]: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI15 is characterized by early-onset recurrent fractures, bone deformity, significant reduction of bone density, short stature, and, in some patients, blue sclerae. Tooth development and hearing are normal. Learning and developmental delays and brain anomalies have been observed in some patients. {ECO:0000269 PubMed:23434763, ECO:0000269 PubMed:23499309, ECO:0000269 PubMed:23499310, ECO:0000269 PubMed:23656646}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(23) Novoseek inferred disease relationships for WNT1 Gene

Disease -log(P) Hits PubMed IDs
cerebellar hypoplasia 57.8 1
mammary tumor 53.4 3
familial adenomatous polyposis 39.1 4
tumors 34.2 28
cancer 29.9 15

Relevant External Links for WNT1

Genetic Association Database (GAD)
WNT1
Human Genome Epidemiology (HuGE) Navigator
WNT1
Tumor Gene Database (TGDB):
WNT1
genes like me logo Genes that share disorders with WNT1: view

Publications for WNT1 Gene

  1. The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences. (PMID: 2998762) van Ooyen A. … Nusse R. (EMBO J. 1985) 2 3 4
  2. Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization. (PMID: 3281802) Arheden K. … Mitelman F. (Cytogenet. Cell Genet. 1988) 2 3
  3. WNT10A and WNT6, clustered in human chromosome 2q35 region with head- to-tail manner, are strongly co-expressed in SW480 cells. (PMID: 11350055) Kirikoshi H. … Katoh M. (Biochem. Biophys. Res. Commun. 2001) 3 23
  4. Wnt pathway is involved in advanced gastric carcinoma. (PMID: 18705344) Zhang H. … Xue Y. (Hepatogastroenterology 2008) 3 23
  5. Wnt1 overexpression promotes tumour progression in non-small cell lung cancer. (PMID: 18790633) Huang C.L. … Ueno M. (Eur. J. Cancer 2008) 3 23

Products for WNT1 Gene

  • Addgene plasmids for WNT1

Sources for WNT1 Gene

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