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WNT1 Gene

protein-coding   GIFtS: 68
GCID: GC12P049372

Wingless-Type MMTV Integration Site Family, Member 1


(Previous symbol: INT1)
  See WNT1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 11 2     OI152 5
INT11 2 3 5     Proto-Oncogene Wnt-12
Proto-Oncogene Int-1 Homolog2 3     Wingless-Type MMTV Integration Site Family, Member 1 (Oncogene INT1)2
BMND162 5     

External Ids:    HGNC: 127741   Entrez Gene: 74712   Ensembl: ENSG000001250847   OMIM: 1648205   UniProtKB: P046283   

Export aliases for WNT1 gene to outside databases

Previous GC identifers: GC12M049438 GC12P049088 GC12P047658 GC12P046403


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT1 Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in
evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the
amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the
mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an
autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested
that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with
another family member, WNT10B, in the chromosome 12q13 region. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT1 Gene:
WNT1 (wingless-type MMTV integration site family, member 1) is a protein-coding gene. Diseases associated with WNT1 include osteogenesis imperfecta, type xv, and osteoporosis, early-onset autosomal dominant. GO annotations related to this gene include transcription regulatory region DNA binding and protein domain specific binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT1_HUMAN, P04628
Function: Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental
processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental
protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell
diameters. Has a role in osteoblast function and bone development

Gene Wiki entry for WNT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT1 gene promoter:
         SREBP-1c   E2F-2   HNF-4alpha2   HNF-4alpha1   SREBP-1b   PPAR-gamma1   E2F-1   SREBP-1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT1 promoter sequence
   Search Chromatin IP Primers for WNT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

WNT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P049372:  view genomic region     (about GC identifiers)

Start:
49,372,236 bp from pter      End:
49,376,396 bp from pter
Size:
4,161 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WNT1_HUMAN, P04628 (See protein sequence)
Recommended Name: Proto-oncogene Wnt-1 precursor  
Size: 370 amino acids; 40982 Da
Subunit: Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3 (By similarity). Interacts with WLS (By
similarity)
Secondary accessions: Q5U0N2

Explore the universe of human proteins at neXtProt for WNT1: NX_P04628

Explore proteomics data for WNT1 at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-224 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-93. Palmitoylation is necessary for proper trafficking to cell surface1
  • Glycosylation2 at Asn29, Asn316, Asn346, Asn359

  • See WNT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005421.1  
    ENSEMBL proteins: 
     ENSP00000293549  
    Reactome Protein details: P04628

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR009139 Wnt1
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P04628

    ProtoNet protein and cluster: P04628

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT1_HUMAN, P04628
    Similarity: Belongs to the Wnt family


    Find genes that share domains with WNT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT1_HUMAN, P04628
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental
    processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental
    protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell
    diameters. Has a role in osteoblast function and bone development

         Genatlas biochemistry entry for WNT1:
    wingless-type MMTV integration site 1,Drosophila wingless (wg),segment polarity gene homolog,modulating cell fate
    and cell behavior during vertebrate development e

         Summary: 
    During embryonic development, WNT1 as signaling molecule is secreted from the following cells:
                
    Neural Tube: Spinal Neural Tube Cells (Neural Tube)
    Neural Ectoderm: Isthmus Cells (Neural Plate)

    It affects the following cells:
          selected tissues (see all 3)      fully expand
    Somite: Dermal Progenitor Cells (Sacral Dorsomedial Dermomyotome Lip), Dermal Progenitor Cells (Lumbar Central Dermomyotome)      fully expand to see all 8 cells
    Neural Tube: Meso-diencephalic Dopaminergic Precursor Cells (Diencephalic Ventricular Zone), Meso-diencephalic Dopaminergic Precursor Cells (Mesencephalic Ventricular Zone)      fully expand to see all 2 cells

    WNT1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Brain: Neuron-like cells, Neuron-like cells
    and also in: Retinoic acid-induced cells, Retinoic acid-induced cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IC19756656
    GO:0005125cytokine activity ISS--
    GO:0005515protein binding ----
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with WNT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WNT1:
     Decreased p24 protein expressi 

         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Wnt1):
     behavior/neurological  cellular  craniofacial  embryogenesis  hearing/vestibular/ear 
     hematopoietic system  immune system  mortality/aging  muscle  nervous system 
     respiratory system  skeleton 

    Find genes that share phenotypes with WNT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for WNT1: Wnt1tm1Amc Wnt1tm1Mrc Wnt1tm1Brd

       genOway: Develop your customized and physiologically relevant rodent model for WNT1

    miRNA
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    miRTarBase miRNAs that target WNT1:
    hsa-mir-122-5p (MIRT006421), hsa-let-7e-5p (MIRT005718), hsa-mir-34a-5p (MIRT001231)

    Block miRNA regulation of human, mouse, rat WNT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WNT1 (see all 58):
    hsa-miR-3678-3p hsa-miR-140-5p hsa-miR-1321 hsa-miR-429 hsa-let-7d hsa-miR-139-5p hsa-miR-486-3p hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidWNT1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for WNT1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WNT1_HUMAN, P04628: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endosome3
    plasma membrane3
    nucleus2
    cytoskeleton1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--
    GO:0005737cytoplasm IDA11793365
    GO:0005788endoplasmic reticulum lumen TAS--

    Find genes that share ontologies with WNT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT1 About   (see all 32)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58


    Find genes that share SuperPaths with WNT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT1
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT1 (see all 10)
        Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Reelin Pathway (Cajal-Retzius cells)
    GSK3 Signaling

    1 Tocris Bioscience Pathway for WNT1
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT1
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    Selected BioSystems Pathways for WNT1 (see all 10)
        TGF Beta Signaling Pathway
    Wnt Signaling Pathway
    Adipogenesis
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)

    2 Sino Biological Pathways for WNT1
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    Selected Reactome Pathways for WNT1 (see all 6)
        Transcriptional regulation of white adipocyte differentiation
    disassembly of the destruction complex and recruitment of AXIN to the membrane
    PCP/CE pathway
    WNT ligand biogenesis and trafficking
    TCF dependent signaling in response to WNT


    Selected Kegg Pathways  (Kegg details for WNT1) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT1: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Stem Cells in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT1 (P046283 ENSP000002935494) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKP349253, ENSP000002960844I2D: score=3 STRING: ENSP00000296084
    FZD1Q9UP383, ENSP000002879344I2D: score=1 STRING: ENSP00000287934
    KLQ9UEF73, ENSP000003694424I2D: score=1 STRING: ENSP00000369442
    WIF1Q9Y5W53, ENSP000002865744I2D: score=1 STRING: ENSP00000286574
    LRP6O755813, ENSP000002613494I2D: score=3 STRING: ENSP00000261349
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 51):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000578embryonic axis specification ISS--
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0007267cell-cell signaling ISS--
    GO:0007275multicellular organismal development ----

    Find genes that share ontologies with WNT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT1

    10 Novoseek inferred chemical compound relationships for WNT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 47.8 6 9601641 (1), 12213737 (1), 17691973 (1), 10861796 (1) (see all 6)
    lithium 34.2 2 10861796 (1), 15592505 (1)
    retinoic acid 24.2 13 11358845 (5), 7958454 (4)
    oligonucleotide 0 1 18461473 (1)
    progesterone 0 2 12213737 (1), 17074804 (1)
    tyrosine 0 2 17897439 (1), 8288227 (1)
    phosphatidylinositol 0 1 12154096 (1)
    agar 0 1 11980918 (1)
    estrogen 0 4 12469206 (2), 17897439 (1), 15824740 (1)
    glutamate 0 1 8226929 (1)



    Find genes that share compounds with WNT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WNT1 gene: 
    NM_005430.3  

    Unigene Cluster for WNT1:

    Wingless-type MMTV integration site family, member 1
    Hs.248164  [show with all ESTs]
    Unigene Representative Sequence: NM_005430
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000293549(uc001rsu.3)
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      QuantiFast Probe-based Assays in human, mouse, rat WNT1

    Additional mRNA sequence: 

    BC074798.2 BC074799.2 BT019429.1 

    1 DOTS entry:

    DT.91710309 

    3 AceView cDNA sequences:

    BC074798 NM_005430 BC074799 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WNT1 Expression
    About this image


    WNT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Dopaminergic Progenitor Cells Substantia Nigra pars Compacta
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 15 entries
             Meso-diencephalic Dopaminergic Precursor Cells Diencephalic Ventricular Zone
             Telencephalon
     
     Neurons
             Dopaminergic Progenitor Cells Substantia Nigra pars Compacta
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 6 entries
             Cranial Neural Crest Cells Cranial Neural Crest
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 4 entries
             Mesencephalic Neural Crest Cells Prechordal Mesenchyme
    WNT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248164
        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT1: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Stem Cells in human mouse rat
              Adipogenesis in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WNT1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt11 , 5 wingless-related MMTV integration site 11, 5 91.53(n)1
    98.92(a)1
      15 (54.65 cM)5
    224081  NM_021279.41  NP_067254.11 
     987898575 
    chicken
    (Gallus gallus)
    Aves WNT11B6
    Gallus gallus wingless-type MMTV integration site ...
    33(a)
    many ↔ many
    4(1181326-1183490)
    lizard
    (Anolis carolinensis)
    Reptilia WNT16
    wingless-type MMTV integration site family, member...
    85(a)
    1 ↔ 1
    2(94044491-94074793)
    African clawed frog
    (Xenopus laevis)
    Amphibia X13138.12   -- 72.82(n)    X13138.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt11 wingless-type MMTV integration site family, member more 71.64(n)
    79.53(a)
      30128  NM_001201398.1  NP_001188327.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wg1 , 3 frizzled-2 receptor signaling pathway
    frizzled-2 more3
    wingless1
    58(a)
    (best of 3)3
    62.08(n)1
    60.78(a)1
      2 27F13
    340091  NM_078778.41  NP_523502.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mom-23 WNT family protein 31(a)
    (best of 2)
      V(8358695-8360444)   --


    ENSEMBL Gene Tree for WNT1 (if available)
    TreeFam Gene Tree for WNT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT1 gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  
    WNT42  WNT7A2  WNT7B2  WNT32  
    18 SIMAP similar genes for WNT1 using alignment to 1 protein entry:     WNT1_HUMAN:
    WNT3    WNT4    WNT3A    WNT7A    WNT7B    WNT16
    WNT2    WNT2B    WNT5A    WNT11    WNT8B    WNT5B
    WNT8A    WNT6    WNT9A    WNT10B    WNT9B    WNT10A

    Find genes that share paralogs with WNT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    WNT1_HUMAN, P04628: Genetic variations in WNT1 define the bone mineral density quantitative trait locus 16 (BMND16)
    [MIM:615221]. Variance in bone mineral density influences bone mass, contributes to size determination in the
    general population, and is a susceptibility factor for osteoporotic fractures


    Selected SNPs for WNT1 (see all 122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0696294
    Osteoporosis (OSTEOP)4--see VAR_0696292 C G mis40--------
    VAR_0696324
    Osteogenesis imperfecta 15 (OI15)4--see VAR_0696322 V F mis40--------
    VAR_0696304
    Osteoporosis (OSTEOP)4--see VAR_0696302 R W mis40--------
    VAR_0696274
    Osteogenesis imperfecta 15 (OI15)4--see VAR_0696272 C F mis40--------
    VAR_0696284
    Osteogenesis imperfecta 15 (OI15)4--see VAR_0696282 G C mis40--------
    VAR_0696314
    Osteogenesis imperfecta 15 (OI15)4--see VAR_0696312 F C mis40--------
    rs1169326871,2
    C,F--46401781(+) CCAGCC/TTGTAA 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1134348591,2
    C,F--49203787(+) GAGTCC/GCTGGG 1 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs47606621,2
    C,F,A,H--49203841(-) GGATAC/TCCAGA 1 -- us2k119Minor allele frequency- T:0.31NS EA NA CSA WA 2344
    rs1928286611,2
    --49203853(+) AGTGTG/TGTGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT1 (49372236 - 49376396 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WNT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832404CNV Gain17160897

    Human Gene Mutation Database (HGMD): WNT1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT1
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164820   
    OMIM disorders: 615220  615221  
    UniProtKB/Swiss-Prot: WNT1_HUMAN, P04628
  • Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and
    deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile
    bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of
    multifactorial etiology and is usually clinically silent until a fracture occurs. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry
  • Osteogenesis imperfecta 15 (OI15) [MIM:615220]: An autosomal recessive form of osteogenesis imperfecta, a
    connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after
    minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and
    perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis
    imperfecta, hearing loss, and blue sclerae. OI15 is characterized by early-onset recurrent fractures, bone
    deformity, significant reduction of bone density, short stature, and, in some patients, blue sclerae. Tooth
    development and hearing are normal. Learning and developmental delays and brain anomalies have been observed in
    some patients. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 13 diseases for WNT1:    
    About MalaCards
    osteogenesis imperfecta, type xv    osteoporosis, early-onset autosomal dominant    osteoporosis, involutional    osteoporosis, postmenopausal, susceptibility
    osteoporosis, postmenopausal    osteoporosis    osteogenesis imperfecta type 4    cerebellar hypoplasia
    osteogenesis imperfecta type iii    myxoid liposarcoma    familial adenomatous polyposis    colon cancer
    hepatocellular carcinoma


    Find genes that share disorders with WNT1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for WNT1 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerebellar hypoplasia 57.8 1 11815869 (1)
    mammary tumor 53.4 3 8738604 (1), 15824740 (1), 17970048 (1)
    familial adenomatous polyposis 39.1 4 16329837 (2), 12213737 (1), 11345525 (1)
    tumors 34.2 51 19423534 (4), 18209144 (4), 18097596 (4), 11358845 (2) (see all 17)
    cancer 29.9 26 15068666 (5), 11358845 (2), 11149923 (2), 12469206 (2) (see all 8)
    breast cancer 28.5 15 18059186 (3), 19580428 (1), 15736421 (1), 17897439 (1) (see all 10)
    pheochromocytoma 24.1 5 12470708 (1), 10837918 (1)
    colon cancer 22.5 1 9843955 (1)
    colorectal tumors 22.4 1 11345525 (1)
    hepatocellular carcinoma 19.5 6 17908501 (3), 19778454 (1), 19423534 (1), 18461473 (1)

    Genetic Association Database (GAD): WNT1
    Human Genome Epidemiology (HuGE) Navigator: WNT1 (3 documents)
    Tumor Gene Database (TGDB): WNT1

    Export disorders for WNT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT1 gene, integrated from 10 sources (see all 263):
    (articles sorted by number of sources associating them with WNT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences. (PubMed id 2998762)1, 2, 3 van Ooyen A.... Nusse R. (EMBO J. 1985)
    2. WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta. (PubMed id 23656646)1, 2 Laine C.M.... Maekitie O. (N. Engl. J. Med. 2013)
    3. WNT1 mutations in families affected by moderately severe and progressive recessive osteogenesis imperfecta. (PubMed id 23499310)1, 2 Pyott S.M.... Byers P.H. (Am. J. Hum. Genet. 2013)
    4. Mutations in WNT1 cause different forms of bone fragility. (PubMed id 23499309)1, 2 Keupp K.... Wollnik B. (Am. J. Hum. Genet. 2013)
    5. Mutations in WNT1 are a cause of osteogenesis imperfecta. (PubMed id 23434763)1, 2 Fahiminiya S....Rauch F. (J. Med. Genet. 2013)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization. (PubMed id 3281802)1, 3 Arheden K....Mitelman F. (Cytogenet. Cell Genet. 1988)
    9. Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. (PubMed id 17289346)1, 9 Chong Z.Z....Maiese K. (Cell. Signal. 2007)
    10. The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line. (PubMed id 19756656)1, 9 Zhang L....Zheng J. (Pediatr. Surg. Int. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7471 HGNC: 12774 AceView: WNT1 Ensembl:ENSG00000125084 euGenes: HUgn7471
    ECgene: WNT1 Kegg: 7471 H-InvDB: WNT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WNT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT1 gene:
    Search GeneIP for patents involving WNT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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