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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNK3 Gene

protein-coding   GIFtS: 57
GCID: GC0XM054235

WNK lysine deficient protein kinase 3

(Previous names: protein kinase, lysine deficient 3 )
(Previous symbol: PRKWNK3)
 Explore 5 diseases affiliated with
WNK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WNK3    

Aliases
for WNK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
WNK Lysine Deficient Protein Kinase 31 2     Protein Kinase, Lysine Deficient 31
PRKWNK31 2 3 5     Serine/Threonine-Protein Kinase WNK32
Protein Kinase With No Lysine 32 3     Protein Kinase Lysine-Deficient 33
EC 2.7.11.13 8     EC 2.7.118
KIAA15663 5     

External Ids:    HGNC: 145431   Entrez Gene: 652672   Ensembl: ENSG000001966327   OMIM: 3003585   UniProtKB: Q9BYP73   

Export aliases for WNK3 gene to outside databases

Previous GC identifers: GC0XM054106 GC0XM051270


Summaries
for WNK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNK3:
This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family
members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family
member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the
increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: WNK3_HUMAN, Q9BYP7
Function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell
signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters
and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of
SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level
via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a
non-catalytic manner
Function: Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and
inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the
activity of SLC12A3

Gene Wiki entry for WNK3


Genomic Views
for WNK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011630.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNK3 gene promoter:
         AhR   RFX1   RREB-1   Nkx2-5   CUTL1   Arnt   FOXJ2 (long isoform)   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for WNK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22

WNK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNK3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM054235:  view genomic region     (about GC identifiers)

Start:
 54,219,256 bp from pter      End:
 54,385,075 bp from pter
Size:
 165,820 bases      Orientation:
 minus strand

Proteins
for WNK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WNK3_HUMAN, Q9BYP7 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase WNK3  
Size: 1800 amino acids; 198416 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with WNK1 and WNK4
Subcellular location: Cytoplasm
Caution: Cys-176 is present instead of the conserved Lys which is expected to be an active site residue. Lys-159
appears to fulfill the required catalytic function
Secondary accessions: B1AKG2 Q5JRC1 Q6JP76 Q8TCX6 Q9HCK6
Alternative splicing: 4 isoforms:  Q9BYP7-1   Q9BYP7-2   Q9BYP7-3   Q9BYP7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WNK3: NX_Q9BYP7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BYP7

    • 4/17 DME Specific Peptides for WNK3 (Q9BYP7) (see all 17)
     EYPYSEC  YDESVDV  PPIIHRD  DLLNHAFF 

    WNK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001002838.1  NP_065973.2  

    ENSEMBL proteins: 
     ENSP00000364312   ENSP00000364301   ENSP00000401816   ENSP00000346667  

    Human Recombinant Protein Products: 
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    Uscn Proteins for WNK3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16501604
    GO:0005912adherens junction ISS--
    GO:0005923tight junction ISS--


    WNK3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for WNK3

    Protein Domains /
    Families
    for WNK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WNK3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR024678 Kinase_OSR1/WNK_CCT
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9BYP7

    ProtoNet protein and cluster: Q9BYP7

    UniProtKB/Swiss-Prot: WNK3_HUMAN, Q9BYP7
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for WNK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WNK3_HUMAN, Q9BYP7
    Function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell
    signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters
    and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of
    SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level
    via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a
    non-catalytic manner
    Function: Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and
    inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the
    activity of SLC12A3
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activation requires autophosphorylation of Ser-308. Phosphorylation of Ser-304 also promotes
    increased activity (By similarity). Kinase activity is inhibited by WNK4

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-1243 hsa-miR-200b hsa-miR-130b hsa-miR-509-3-5p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmid: WNK3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for WNK3

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA16275913
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0005515protein binding IPI16501604
    GO:0005524ATP binding ISS--
    GO:0016301kinase activity ----


    WNK3 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for WNK3:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Lamellipodia cells  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Wnk3tm1.1Esoh for WNK3
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Wnk3):
     cardiovascular system  homeostasis/metabolism  normal  renal/urinary system 

    WNK3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WNK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Diuretics Pathway, Pharmacodynamics
    		Diuretics Pathway, Pharmacodynamics1.00


    1 PharmGKB Pathway for WNK3
        Diuretics Pathway, Pharmacodynamics

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WNK3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for WNK3 (Q9BYP71, 3 ENSP000003466674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP3P425741, 3, ENSP000003110324EBI-1182602,EBI-524064 I2D: score=1 STRING: ENSP00000311032
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0007243intracellular protein kinase cascade ISS--
    GO:0010765positive regulation of sodium ion transport IDA16275913
    GO:0010800positive regulation of peptidyl-threonine phosphorylation IDA16275913
    GO:0032414positive regulation of ion transmembrane transporter activity IDA16275913


    WNK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for WNK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNK3

    3 HMDB Compounds for WNK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about WNK3 

    Transcripts
    for WNK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WNK3 gene (2 alternative transcripts): 
    NM_001002838.3  NM_020922.4  

    Unigene Cluster for WNK3:

    WNK lysine deficient protein kinase 3
    Hs.92423  [show with all ESTs]
    Unigene Representative Sequence: NM_020922
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375169(uc004dtd.2) ENST00000375159 ENST00000458404 ENST00000354646(uc004dtc.2)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNK3
    8/135 QIAGEN miScript miRNA Assays for microRNAs that regulate WNK3 (see all 135):
    hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-1243 hsa-miR-200b hsa-miR-130b hsa-miR-509-3-5p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmid: WNK3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNK3

    Additional cDNA sequence: 

    AB046786.1 AJ409088.2 AK054999.1 AK124653.1 AY082340.1 AY352048.1 

    2 DOTS entries:

    DT.209855  DT.208569 

    24/30 AceView cDNA sequences (see all 30):

    AI341748 AB046786 CD644002 AW592419 NM_020922 NM_001002838 AY082340 Z44479 
    AI190890 AJ409088 AA399218 AY352048 AV654913 M78294 AW172290 AI004108 
    AA412230 BX282619 AV745759 AV746356 AV745332 T10114 R41053 R41152 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for WNK3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                    -                       -               

    ExUns: 24b
    SP1:      
    SP2:      


    ECgene alternative splicing isoforms for WNK3

    Expression
    for WNK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCTTGCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See WNK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNK3

    SOURCE GeneReport for Unigene cluster: Hs.92423

    UniProtKB/Swiss-Prot: WNK3_HUMAN, Q9BYP7
    Tissue specificity: Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta,
    fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and
    spleen. Isoform 1 is brain-specific. Isoform 3 is kidney-specific

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNK3

    Orthologs
    for WNK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WNK3 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 78(a)
    30(a)
    		 1 ↔ 1
    possible ortholog
    		 1(205373643-205435164)
    1(205439218-205490633)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005370481 serine/threonine-protein kinase WNK3-like 65.69(n)
    74.18(a)    		   100537048  XM_003201205.1  XP_003201253.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Wnk6
    		 --
    		 14(a)
    		 1 → many
    		 3L(21536950-21548028)
    worm
    (Caenorhabditis elegans)    		 Secernentea wnk-16
    		 mammalian WNK-type protein kinase homolog family m...
    		 18(a)
    		 1 → many
    		 IV(9200100-9212216)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G555606
    ATWNK106
    (see all 11)    		 putative serine/threonine-protein kinase WNK10
    (see all 11)    		 41(a)
    33(a)
    (see all 11)    		 many ↔ many
    many ↔ many
    (see all 11)    		 5(22506302-22507879)
    1(24019490-24022310)
    rice
    (Oryza sativa)    		 Liliopsida Os.181832 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.16(n)    AK073845.1 


    ENSEMBL Gene Tree for WNK3 (if available)
    TreeFam Gene Tree for WNK3 (if available) 

    Paralogs
    for WNK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNK3 gene
    WNK12  WNK42  NRBP12  WNK22  NRBP22  
    5 SIMAP similar genes for WNK3 using alignment to 2 protein entries:     WNK3_HUMAN (see all proteins):
    WNK2    CDK4    MST094    STK17A    WNK4

    WNK3 for paralogs           About GeneDecksing



    Genomic Variants
    for WNK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1432 NCBI SNPs in WNK3 are shown (see all 1432)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1425101651,2
    		--54218801(+) AATGTA/GTCTGA 2 -- ds50010--------
    rs1899037781,2
    		--54218966(+) GCATTG/TTAAGT 2 -- ds50010--------
    rs1471282031,2
    		--54218977(+) GGAAAC/TAGTAA 2 -- ds50010--------
    rs1825321201,2
    		--54219068(+) TGAGAC/GCAACT 2 -- ds50010--------
    rs1404122691,2
    		--54219100(+) CAAGCA/GTGAAA 2 -- ds50010--------
    rs1112690181,2
    		C,--54219270(+) CTATGA/GCAGCA 2 -- ut311Minor allele frequency- G:0.00CSA 1
    rs1846766121,2
    		--54219302(+) ATTTAA/TCACAG 2 -- ut310--------
    rs1883458331,2
    		--54219366(+) CAATGA/GTTGGG 2 -- ut310--------
    rs1808598411,2
    		--54219907(+) AGTTTA/CTCTCT 2 -- ut310--------
    rs172766581,2
    		C,F,H,--54220025(+) AAATAA/GCTTTA 2 -- ut3113Minor allele frequency- G:0.04NA NS EA 1254

    HapMap Linkage Disequilibrium report for WNK3 (54219256 - 54385075 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for WNK3
         1 CNV: 23256
    Human Gene Mutation Database (HGMD): WNK3

    Locus Specific Mutation Databases (LSDB): WNK3

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for WNK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WNK3 for disorders           About GeneDecksing

    OMIM gene information: 300358    OMIM disorders: --

    5 diseases for WNK3:    About MalaCards
    pseudohypoaldosteronism type ii    pseudohypoaldosteronism    hypertension    schizophrenia
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for WNK3:
    Pseudohypoaldosteronism
    Human Genome Epidemiology (HuGE) Navigator: WNK3 (4 documents)

    Export disorders for WNK3 gene to outside databases

    Publications
    for WNK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNK3 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with WNK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Renal and brain isoforms of WNK3 have opposite effect s on NCCT expression. (PubMed id 19470686)1, 2, 9 Glover M....O'Shaughnessy K.M. (2009)
    2. WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. (PubMed id 16275913)1, 2, 9 Rinehart J....Lifton R.P. (2005)
    3. Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3). (PubMed id 15194194)1, 2, 9 Holden S.... Raymond F.L. (2004)
    4. Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway. (PubMed id 16501604)1, 2, 9 Verissimo F....Jordan P. (2006)
    5. Similar Effects of all WNK3 Variants upon SLC12 Cotransporters. (PubMed id 21613606)1, 2 Cruz-Rangel S.... Mercado A. (2011)
    6. Serum and glucocorticoid-induced kinase (SGK) 1 and t he epithelial sodium channel are regulated by multiple with no lysine (WNK) fam ily members. (PubMed id 20525693)1, 2 Heise C.J....Cobb M.H. (2010)
    7. WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway. (PubMed id 18768590)1, 2 Zhang W....Peng J.B. (2008)
    8. The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. (PubMed id 17975670)1, 2 Yang C.L....Ellison D.H. (2007)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    10. WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. (PubMed id 11571656)1, 2 Verissimo F. and Jordan P. (2001)

    External Searches for WNK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing WNK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65267 HGNC: 14543 AceView: PRKWNK3 Ensembl:ENSG00000196632 euGenes: HUgn65267
    ECgene: WNK3 H-InvDB: WNK3

    Other Databases showing WNK3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1566

    Specialized Databases showing WNK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNK3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WNK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WNK3 gene:
    Search GeneIP for patents involving WNK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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