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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNK2 Gene

protein-coding   GIFtS: 59
GCID: GC09P095947

WNK Lysine Deficient Protein Kinase 2

(Previous name: serologically defined colon cancer antigen 43)
(Previous symbols: SDCCAG43, PRKWNK2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WNK Lysine Deficient Protein Kinase 21 2     NY-CO-432
Serologically Defined Colon Cancer Antigen 431 2 3     P/OKcl.132
PRKWNK21 2 3     Mitogen-Activated Protein Kinase Kinase Kinase2
SDCCAG431 2 3     Protein Kinase, Lysine Deficient 22
Antigen NY-CO-432 3     Serine/Threonine-Protein Kinase WNK22
Protein Kinase Lysine-Deficient 22 3     KIAA17603
Protein Kinase With No Lysine 22 3     PRK5
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 145421   Entrez Gene: 652682   Ensembl: ENSG000001652387   OMIM: 6062495   UniProtKB: Q9Y3S13   

Export aliases for WNK2 gene to outside databases

Previous GC identifers: GC09P093027 GC09P094987 GC09P065623


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNK2 Gene:
The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase
superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling
survival, and proliferation. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Sep 2013)

GeneCards Summary for WNK2 Gene: 
WNK2 (WNK lysine deficient protein kinase 2) is a protein-coding gene. Diseases associated with WNK2 include pseudohypoaldosteronism type ii, and colon cancer. GO annotations related to this gene include protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is WNK1.

UniProtKB/Swiss-Prot: WNK2_HUMAN, Q9Y3S1
Function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell
signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride
cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B,
SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and
the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this
modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by
controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display
reciprocal activity

Gene Wiki entry for WNK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNK2 gene promoter:
         C/EBPbeta   RP58   AP-1   ATF-2   Lmo2   MyoD   Egr-4   Evi-1   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for WNK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22.3

WNK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNK2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P095947:  view genomic region     (about GC identifiers)

Start:
95,947,198 bp from pter      End:
96,082,854 bp from pter
Size:
135,657 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WNK2_HUMAN, Q9Y3S1 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase WNK2  
Size: 2297 amino acids; 242676 Da
Cofactor: Magnesium (By similarity)
Subunit: Forms a complex with the phosphorylated form of STK39 (By similarity)
Subcellular location: Cytoplasm. Cell membrane
Caution: Cys-224 is present instead of the conserved Lys which is expected to be an active site residue. Lys-207
appears to fulfill the required catalytic function
Sequence caution: Sequence=AAH37965.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5VWF1 Q5VWF2 Q8IY36 Q9C0A3 Q9H3P4
Alternative splicing: 4 isoforms:  Q9Y3S1-1   Q9Y3S1-2   Q9Y3S1-3   Q9Y3S1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WNK2: NX_Q9Y3S1

Explore proteomics data for WNK2 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3S1

  • 4/13 DME Specific Peptides for WNK2 (Q9Y3S1) (see all 13)
     EYPYSEC  IEQMKDV  YDESVDV  PPIIHRD 

    WNK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WNK2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269323.1  NP_006639.3  

    ENSEMBL proteins: 
     ENSP00000412465   ENSP00000297954   ENSP00000415038   ENSP00000414622   ENSP00000390441  
     ENSP00000413325   ENSP00000378860   ENSP00000378858   ENSP00000297876   ENSP00000411181  
     ENSP00000348347  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNK2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17667937
    GO:0005886plasma membrane IEA--

    WNK2 for ontologies           About GeneDecksing



    WNK2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for WNK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: WNK lysine deficient protein kinase 2 
    Wnk family

    4 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR024678 Kinase_OSR1/WNK_CCT
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y3S1

    ProtoNet protein and cluster: Q9Y3S1

    UniProtKB/Swiss-Prot: WNK2_HUMAN, Q9Y3S1
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily
    Similarity: Contains 1 protein kinase domain


    WNK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNK2_HUMAN, Q9Y3S1
    Function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell
    signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride
    cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B,
    SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and
    the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this
    modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by
    controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display
    reciprocal activity
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activation requires autophosphorylation of Ser-356. Phosphorylation of Ser-352 also promotes
    increased activity (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding ISS--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    WNK2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WNK2:
     Increased cell death HMECs cel 

         1 MGI phenotypic allele for Wnk2 (no phenotypes)

    WNK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wnk2tm1Lex for WNK2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for WNK2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WNK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for WNK2 (Q9Y3S12, 3 ENSP000002979544) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110875 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111619 I2D: score=3 STRING: ENSP00000357656
    ATXN1P542533, ENSP000002447694I2D: score=2 STRING: ENSP00000244769
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA--
    GO:0007243intracellular protein kinase cascade ISS--
    GO:0008285negative regulation of cell proliferation IMP17667937
    GO:0046777protein autophosphorylation IDA17667937
    GO:0070373negative regulation of ERK1 and ERK2 cascade IMP17667937

    WNK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNK2

    3 HMDB Compounds for WNK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about WNK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WNK2 gene (2 alternative transcripts): 
    NM_001282394.1  NM_006648.3  

    Unigene Cluster for WNK2:

    WNK lysine deficient protein kinase 2
    Hs.654856  [show with all ESTs]
    Unigene Representative Sequence: AB051547
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000448039(uc010mrd.1) ENST00000297954(uc004ati.1) ENST00000432730(uc011lud.1)
    ENST00000411624(uc004atk.3) ENST00000464625 ENST00000478583 ENST00000448251(uc004atl.1)
    ENST00000462595 ENST00000453718 ENST00000474009 ENST00000479696 ENST00000467401
    ENST00000460335 ENST00000471076 ENST00000395477(uc004atj.3) ENST00000395475(uc010mrc.1)
    ENST00000349097 ENST00000427277
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    Additional mRNA sequence: 

    AB044546.1 AB051547.2 AJ242724.4 AK000694.1 AK055151.1 AK093910.1 AK124314.1 AK310390.1 
    BC037965.1 

    14 DOTS entries:

    DT.100022041  DT.100739040  DT.91801966  DT.442052  DT.95325142  DT.425812  DT.91651393  DT.99999119 
    DT.40218586  DT.100016290  DT.121164654  DT.40109714  DT.92419749  DT.91789567 

    24/110 AceView cDNA sequences (see all 110):

    AA368833 BM671000 AB051547 AJ242724 BQ925250 AW337451 AA283935 AW419087 
    BQ637666 BU732203 BC037965 BM907282 AW001397 AA662951 CA946368 AW500011 
    AI632414 BE561168 BG231979 AI217214 BQ222235 AL134251 W73992 AA367042 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for WNK2 (see all 17)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^
    SP1:                                                                                                                                            -               
    SP2:                    -                                               -                                                                                       
    SP3:                                                                                                                                            -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                              -                             -               

    ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32a · 32b ^ 33 ^ 34 ^ 35
    SP1:              -                                                                                   -                 -           -     -         
    SP2:                                                                                                                                                
    SP3:              -                                                                                                                                 
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for WNK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNK2 expression in normal human tissues (normalized intensities)      WNK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTCAGTG
    WNK2 Expression
    About this image


    WNK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             postcentral gyrus   
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...

    See WNK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNK2

    SOURCE GeneReport for Unigene cluster: Hs.654856

    UniProtKB/Swiss-Prot: WNK2_HUMAN, Q9Y3S1
    Tissue specificity: Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart,
    brain, skeletal muscle and colon

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WNK2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnk21 , 5 WNK lysine deficient protein kinase 21, 5 81.44(n)1
    81.76(a)1
      13 (25.07 cM)5
    756071  NM_029361.31  NP_083637.21 
     490363035 
    chicken
    (Gallus gallus)
    Aves WNK21 WNK lysine deficient protein kinase 2 69.94(n)
    73.74(a)
      415984  XM_414326.3  XP_414326.3 
    lizard
    (Anolis carolinensis)
    Reptilia WNK26
    Uncharacterized protein
    57(a)
    1 ↔ 1
    GL343225.1(1588925-1672311)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01066573.16
    WNK26
    WNK lysine deficient protein kinase 2
    71(a)
    28(a)
    possible ortholog
    1 ↔ 1
    25(1497582-1507054)
    Zv9_NA593(1432-11789)
    fruit fly
    (Drosophila melanogaster)
    Insecta Wnk6
    --
    17(a)
    possible ortholog
    3L(21536950-21548028)
    worm
    (Caenorhabditis elegans)
    Secernentea wnk-16
    Protein WNK-1, isoform a
    21(a)
    possible ortholog
    IV(9200116-9212232)
    rice
    (Oryza sativa)
    Liliopsida Os.22212 Oryza sativa mitogen activated protein kinase kinase more 77.64(n)    AK100426.1 


    ENSEMBL Gene Tree for WNK2 (if available)
    TreeFam Gene Tree for WNK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNK2 gene
    WNK12  WNK42  NRBP12  NRBP22  WNK32  
    7 SIMAP similar genes for WNK2 using alignment to 11 protein entries:     WNK2_HUMAN (see all proteins):
    WNK3    STK11    WNK4    NEK6    CDK4    STK17A
    WNK1

    WNK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3109 SNPs in WNK2 are shown (see all 3109)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2074703751,2
    Cuntested196055487(+) CCCCCA/G/TCCCCT 1 -- int10--------
    rs1386953821,2
    C,Funtested196061517(+) AGCCAG/ATGATG 2 /N /S mis12Minor allele frequency- A:0.00NA EU 5047
    rs557995421,2
    C--65661820(+) CCAGG-/TGGCCTT 1 -- int11Minor allele frequency- TG:0.00NA 2
    rs1471691411,2
    C--95945238(+) CAGGC-/TACAGG 1 -- us2k10--------
    rs1909375851,2
    --95945327(+) CCAGCA/GGGGCT 1 -- us2k10--------
    rs767865281,2
    C,F--95945359(+) GGTAAC/GAGTTG 1 -- us2k12Minor allele frequency- G:0.02NA 122
    rs1512541871,2
    C--95945759(+) AGAGAA/TCATGG 1 -- us2k10--------
    rs1828320471,2
    --95945976(+) GCCTCC/TCTGGG 1 -- us2k10--------
    rs1404240631,2
    --95946067(+) GGCTGC/GGCTCC 1 -- us2k10--------
    rs1148839711,2
    F--95946153(+) CGCGCC/TGGGCT 1 -- us2k11Minor allele frequency- T:0.13WA 118

    HapMap Linkage Disequilibrium report for WNK2 (95947198 - 96082854 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for WNK2 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738782CNV Deletion23290073
    esv2668317CNV Deletion23128226
    esv2738781CNV Deletion23290073
    nsv509310CNV Insertion20534489
    esv1576972CNV Insertion17803354
    esv2506086CNV Insertion19546169
    esv1441694CNV Insertion17803354
    nsv893582CNV Loss21882294
    nsv415569CNV Loss16902084
    nsv893580CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606249    OMIM disorders: --

    8 diseases for WNK2:    About MalaCards
    pseudohypoaldosteronism type ii    colon cancer    pseudohypoaldosteronism    kidney disease
    hypertension    pancreatic cancer    pancreatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for WNK2:
    Pseudohypoaldosteronism

    WNK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WNK2
    Human Genome Epidemiology (HuGE) Navigator: WNK2 (4 documents)

    Export disorders for WNK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNK2 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with WNK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. (PubMed id 11571656)1, 2, 3 Verissimo F. and Jordan P. (2001)
    2. WNK2 modulates MEK1 activity through the Rho GTPase pathway. (PubMed id 18593598)1, 2, 9 Moniz S....Jordan P. (2008)
    3. WNK2 is a novel regulator of essential neuronal cation-chloride cotransporters. (PubMed id 21733846)1, 2 Rinehart J.... Lifton R.P. (2011)
    4. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    5. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)1, 4 Yoshida T....Yamada Y. (2009)
    8. Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. (PubMed id 17667937)1, 2 Moniz S....Jordan P. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Molecular basis of T cell-mediated recognition of pancreatic cancer cells. (PubMed id 11280764)1, 2 Ito M....Itoh K. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65268 HGNC: 14542 AceView: PRKWNK2 Ensembl:ENSG00000165238 euGenes: HUgn65268
    ECgene: WNK2 H-InvDB: WNK2

    (According to HUGE)
    About This Section
    HUGE: KIAA1760

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WNK2 gene:
    Search GeneIP for patents involving WNK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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