Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WNK2 Gene

Aliases for WNK2 Gene

  • WNK Lysine Deficient Protein Kinase 2 2 3 5
  • Serologically Defined Colon Cancer Antigen 43 2 3 4
  • Protein Kinase Lysine-Deficient 2 3 4
  • Protein Kinase With No Lysine 2 3 4
  • Antigen NY-CO-43 3 4
  • EC 2.7.11.1 4 61
  • SDCCAG43 3 4
  • PRKWNK2 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase 3
  • Serine/Threonine-Protein Kinase WNK2 3
  • P/OKcl.13 3
  • EC 2.7.11 61
  • NY-CO-43 3
  • KIAA1760 4

External Ids for WNK2 Gene

Previous HGNC Symbols for WNK2 Gene

  • SDCCAG43
  • PRKWNK2

Previous GeneCards Identifiers for WNK2 Gene

  • GC09P093027
  • GC09P094987
  • GC09P095947
  • GC09P065623

Summaries for WNK2 Gene

Entrez Gene Summary for WNK2 Gene

  • The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for WNK2 Gene

WNK2 (WNK Lysine Deficient Protein Kinase 2) is a Protein Coding gene. Diseases associated with WNK2 include Gastric Cardia Carcinoma. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WNK1.

UniProtKB/Swiss-Prot for WNK2 Gene

  • Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.

Gene Wiki entry for WNK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNK2 Gene

Genomics for WNK2 Gene

Regulatory Elements for WNK2 Gene

Enhancers for WNK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G093268 1.3 Ensembl ENCODE dbSUPER 8.5 +84.7 84727 1.7 NFIB RAD21 YY1 FOS ZNF843 NR2F2 ZNF530 ZNF24 HNF4A SP7 WNK2 PIR56775
GH09G093110 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.8 -70.3 -70329 6.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 NINJ1 NOL8 PHF2 CARD19 SUSD3 LINC00475 IPPK WNK2 FGD3 FAM120A
GH09G093222 1.3 Ensembl ENCODE dbSUPER 7.5 +40.3 40334 3.3 NFIB MAX KLF17 ZIC2 RFX5 PATZ1 SCRT2 FOSL2 FOS ZNF600 SUSD3 ENSG00000203364 WNK2 PIR56775
GH09G093200 1.5 Ensembl ENCODE dbSUPER 6.2 +22.3 22324 12.9 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF263 SP5 ZHX2 RNU6-829P ENSG00000203364 WNK2 C9orf129 PIR56775
GH09G093298 1 ENCODE 8.7 +115.5 115524 3.0 FOXA2 MLX ARID4B DMAP1 ZNF48 SLC30A9 FOS ZNF263 SP5 ZHX2 RNU6-829P WNK2 PIR56775
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WNK2 on UCSC Golden Path with GeneCards custom track

Promoters for WNK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000238009 545 1401 CTCF RING1 PKNOX1 MXI1 RB1 FUS SAP30 SIN3A RBBP5 ZNF121

Genomic Location for WNK2 Gene

Chromosome:
9
Start:
93,184,155 bp from pter
End:
93,320,572 bp from pter
Size:
136,418 bases
Orientation:
Plus strand

Genomic View for WNK2 Gene

Genes around WNK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNK2 Gene

Proteins for WNK2 Gene

  • Protein details for WNK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3S1-WNK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase WNK2
    Protein Accession:
    Q9Y3S1
    Secondary Accessions:
    • Q5VWF1
    • Q5VWF2
    • Q8IY36
    • Q9C0A3
    • Q9H3P4

    Protein attributes for WNK2 Gene

    Size:
    2297 amino acids
    Molecular mass:
    242676 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with the phosphorylated form of STK39.
    SequenceCaution:
    • Sequence=AAH37965.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for WNK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNK2 Gene

Selected DME Specific Peptides for WNK2 Gene

Q9Y3S1:
  • FTDDLHKLVD
  • PPIIHRD
  • EYPYSEC
  • IEQMKDV
  • KMVTFKFD
  • KIGDLGLA
  • VIGTPEFMAPE
  • FGMCMLEM
  • TELMTSGTL
  • GTPEFMAPE
  • IHRDLKCDNIF
  • YDESVDV
  • VEVAWCELQDRKLTK

Post-translational modifications for WNK2 Gene

Domains & Families for WNK2 Gene

Gene Families for WNK2 Gene

Protein Domains for WNK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3S1

UniProtKB/Swiss-Prot:

WNK2_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
genes like me logo Genes that share domains with WNK2: view

Function for WNK2 Gene

Molecular function for WNK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activation requires autophosphorylation of Ser-356. Phosphorylation of Ser-352 also promotes increased activity (By similarity).
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.

Enzyme Numbers (IUBMB) for WNK2 Gene

Gene Ontology (GO) - Molecular Function for WNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,ISS --
GO:0005524 ATP binding ISS,IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with WNK2: view
genes like me logo Genes that share phenotypes with WNK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WNK2

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WNK2 Gene

Localization for WNK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNK2 Gene

Cytoplasm. Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNK2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 3
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for WNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 17667937
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with WNK2: view

Pathways & Interactions for WNK2 Gene

genes like me logo Genes that share pathways with WNK2: view

Pathways by source for WNK2 Gene

Gene Ontology (GO) - Biological Process for WNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA,IEA 21733846
GO:0008285 negative regulation of cell proliferation IMP 17667937
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction ISS --
GO:0046777 protein autophosphorylation IDA 17667937
genes like me logo Genes that share ontologies with WNK2: view

No data available for SIGNOR curated interactions for WNK2 Gene

Drugs & Compounds for WNK2 Gene

(2) Drugs for WNK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for WNK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with WNK2: view

Transcripts for WNK2 Gene

Unigene Clusters for WNK2 Gene

WNK lysine deficient protein kinase 2:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^
SP1: -
SP2: - -
SP3: -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32a · 32b ^ 33 ^ 34 ^ 35
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8: - - - -
SP9: - - -
SP10: -
SP11: - -
SP12:
SP13: - -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for WNK2 Gene

GeneLoc Exon Structure for
WNK2
ECgene alternative splicing isoforms for
WNK2

Expression for WNK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNK2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x5.4) and Heart - Left Ventricle (x4.8).

Protein differential expression in normal tissues from HIPED for WNK2 Gene

This gene is overexpressed in Retina (14.5), Frontal cortex (8.2), Spleen (8.1), Pancreas (7.1), and Salivary gland (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WNK2 Gene



Protein tissue co-expression partners for WNK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of WNK2 Gene:

WNK2

SOURCE GeneReport for Unigene cluster for WNK2 Gene:

Hs.654856

mRNA Expression by UniProt/SwissProt for WNK2 Gene:

Q9Y3S1-WNK2_HUMAN
Tissue specificity: Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon.

Evidence on tissue expression from TISSUES for WNK2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with WNK2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for WNK2 Gene

Orthologs for WNK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WNK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNK2 34
  • 97.75 (n)
mouse
(Mus musculus)
Mammalia Wnk2 34 16 35
  • 84.44 (n)
rat
(Rattus norvegicus)
Mammalia Wnk2 34
  • 84.38 (n)
cow
(Bos Taurus)
Mammalia WNK2 34 35
  • 82.79 (n)
dog
(Canis familiaris)
Mammalia WNK2 34 35
  • 81.8 (n)
oppossum
(Monodelphis domestica)
Mammalia WNK2 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNK2 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves WNK2 34 35
  • 66.27 (n)
lizard
(Anolis carolinensis)
Reptilia WNK2 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnk2 34
  • 65.74 (n)
zebrafish
(Danio rerio)
Actinopterygii WNK2 35
  • 34 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2383 34
fruit fly
(Drosophila melanogaster)
Insecta Wnk 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea wnk-1 35
  • 25 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.2463 34
rice
(Oryza sativa)
Liliopsida Os.2221 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 79 (a)
OneToMany
Species where no ortholog for WNK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNK2 Gene

ENSEMBL:
Gene Tree for WNK2 (if available)
TreeFam:
Gene Tree for WNK2 (if available)

Paralogs for WNK2 Gene

Paralogs for WNK2 Gene

genes like me logo Genes that share paralogs with WNK2: view

Variants for WNK2 Gene

Sequence variations from dbSNP and Humsavar for WNK2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000014740 -- 93,198,637(+) TCCAC(A/G)GCCTC intron-variant
rs1000025099 -- 93,204,162(+) TAGGG(A/T)GCCAC intron-variant
rs1000030805 -- 93,282,912(+) ATCTC(A/C)ACAAG intron-variant
rs1000060335 -- 93,187,368(+) CTTCT(C/G)GTCTA intron-variant
rs1000062971 -- 93,279,905(+) CCACT(C/G)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNK2 Gene

Variant ID Type Subtype PubMed ID
esv1441694 CNV insertion 17803354
esv1576972 CNV insertion 17803354
esv2506086 CNV insertion 19546169
esv2668317 CNV deletion 23128226
esv2738781 CNV deletion 23290073
esv2738782 CNV deletion 23290073
esv3310587 CNV novel sequence insertion 20981092
esv3331340 CNV duplication 20981092
nsv1117518 CNV tandem duplication 24896259
nsv1117519 CNV tandem duplication 24896259
nsv1129825 CNV tandem duplication 24896259
nsv1137482 CNV deletion 24896259
nsv1161884 CNV deletion 26073780
nsv1161885 CNV duplication 26073780
nsv415527 CNV deletion 16902084
nsv415569 CNV deletion 16902084
nsv415836 CNV deletion 16902084
nsv509310 CNV insertion 20534489
nsv526296 CNV loss 19592680
nsv614880 CNV loss 21841781
nsv824983 CNV gain 20364138
nsv950897 CNV deletion 24416366
nsv950898 CNV deletion 24416366

Variation tolerance for WNK2 Gene

Gene Damage Index Score: 12.28; 94.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNK2 Gene

Human Gene Mutation Database (HGMD)
WNK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNK2 Gene

Disorders for WNK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WNK2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric cardia carcinoma
  • carcinoma of cardia of stomach
- elite association - COSMIC cancer census association via MalaCards
Search WNK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WNK2

Genetic Association Database (GAD)
WNK2
Human Genome Epidemiology (HuGE) Navigator
WNK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNK2
genes like me logo Genes that share disorders with WNK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNK2 Gene

Publications for WNK2 Gene

  1. WNK2 modulates MEK1 activity through the Rho GTPase pathway. (PMID: 18593598) Moniz S. … Jordan P. (Cell. Signal. 2008) 3 4 22 64
  2. WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. (PMID: 11571656) Verissimo F. … Jordan P. (Oncogene 2001) 2 3 4 64
  3. WNK2 is a novel regulator of essential neuronal cation-chloride cotransporters. (PMID: 21733846) Rinehart J. … Lifton R.P. (J. Biol. Chem. 2011) 3 4 64
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64

Products for WNK2 Gene

Sources for WNK2 Gene

Content
Loading form....