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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WLS Gene

protein-coding   GIFtS: 51
GCID: GC01M068564

wntless homolog (Drosophila)

(Previous names: chromosome 1 open reading frame 139, G protein-coupled...)
(Previous symbols: C1orf139, GPR177)
 Explore 3 diseases affiliated with
WLS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WLS    

Aliases
for WLS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wntless Homolog (Drosophila)1 2     Protein Evenness Interrupted Homolog2 3
EVI1 2 3 5     Putative NF-Kappa-B-Activating Protein 3732 3
GPR1771 2 3 5     FLJ230911
C1orf1391 2 3     Chromosome 1 Open Reading Frame 1391
MRP1 2     Wls1
G Protein-Coupled Receptor 1771 2     Protein Wntless Homolog2
Mig-141     Putative NFkB Activating Protein 3732
Integral Membrane Protein GPR1772 3     

External Ids:    HGNC: 302381   Entrez Gene: 799712   Ensembl: ENSG000001167297   OMIM: 6115145   UniProtKB: Q5T9L33   

Export aliases for WLS gene to outside databases

Previous GC identifer: GC01M066674


Summaries
for WLS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: WLS_HUMAN, Q5T9L3
Function: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction
plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of
Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during
development (By similarity)

Gene Wiki entry for WLS (GPR177)


Genomic Views
for WLS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for WLS
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WLS promoter sequence
   Search SABiosciences Chromatin IP Primers for WLS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WLS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.2

WLS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WLS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M068564:  view genomic region     (about GC identifiers)

Start:
 68,564,142 bp from pter      End:
 68,698,803 bp from pter
Size:
 134,662 bases      Orientation:
 minus strand

Proteins
for WLS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WLS_HUMAN, Q5T9L3 (See protein sequence)
Recommended Name: Protein wntless homolog precursor  
Size: 541 amino acids; 62253 Da
Subunit: Interacts with WNT3A. Interacts with WNT1, WNT3 and WNT5A (By similarity)
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass
membrane protein
Secondary accessions: B2RNT2 Q5JRS7 Q7Z2Z9 Q8NC43
Alternative splicing: 3 isoforms:  Q5T9L3-1   Q5T9L3-2   Q5T9L3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WLS: NX_Q5T9L3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5T9L3

    • WLS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001002292.3  NP_001180263.1  NP_079187.3  

    ENSEMBL proteins: 
     ENSP00000346829   ENSP00000262348   ENSP00000360015   ENSP00000431552   ENSP00000433690  
     ENSP00000433111   ENSP00000360012   ENSP00000436196   ENSP00000433188   ENSP00000433867  
     ENSP00000360010   ENSP00000446112  

    Human Recombinant Protein Products: 
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    Novus Biologicals WLS Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WLS

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus ----
    GO:0016021integral to membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031410cytoplasmic vesicle ----


    WLS for ontologies           About GeneDecksing



    WLS Antibody Products: 
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    Uscn Antibodies for WLS
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    Uscn ELISAs and CLIAs for WLS

    Protein Domains /
    Families
    for WLS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WLS for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009551 wntless

    Graphical View of Domain Structure for InterPro Entry Q5T9L3

    ProtoNet protein and cluster: Q5T9L3

    UniProtKB/Swiss-Prot: WLS_HUMAN, Q5T9L3
    Similarity: Belongs to the wntless family


    Function
    for WLS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WLS_HUMAN, Q5T9L3
    Function: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction
    plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of
    Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during
    development (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WLS
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate WLS (see all 17):
    hsa-miR-320a hsa-miR-549 hsa-miR-3689b hsa-miR-548v hsa-miR-487a hsa-miR-374c hsa-miR-3121-3p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmid: WLS 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WLS (see all 4)
    OriGene shRNA RFP: WLS
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for WLS

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity ISS--
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI--
    GO:0017147Wnt-protein binding IEA--


    WLS for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for WLS:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Wlstm1.2Whsu for WLS
         12 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Wls):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  integument  limbs/digits/tail  mortality/aging  muscle 
     nervous system  skeleton 

    WLS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WLS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WLS

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for WLS (Q5T9L31, 3 ENSP000003468294) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OPRM1P353721, ENSP000003946244EBI-2868748,EBI-2624570 STRING: ENSP00000394624
    MAN1A2O604763I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    C15orf39ENSP000003538544STRING: ENSP00000353854
    GOLGA7ENSP000002765304STRING: ENSP00000276530
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001707mesoderm formation IEA--
    GO:0007275multicellular organismal development ----
    GO:0009948anterior/posterior axis specification IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade ISS--


    WLS for ontologies           About GeneDecksing



    Drugs & Compounds
    for WLS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WLS
    Search CenterWatch for drugs/clinical trials and news about WLS 

    Transcripts
    for WLS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WLS gene (3 alternative transcripts): 
    NM_001002292.3  NM_001193334.1  NM_024911.6  

    Unigene Cluster for WLS:

    Wntless homolog (Drosophila)
    Hs.647659  [show with all ESTs]
    Unigene Representative Sequence: BX537492
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354777(uc021oor.1) ENST00000262348(uc009wbf.1 uc001def.2 uc001deg.2)
    ENST00000370976 ENST00000498615 ENST00000491811 ENST00000497187 ENST00000534713
    ENST00000533537 ENST00000530486 ENST00000370973 ENST00000471243 ENST00000491076
    ENST00000527864 ENST00000370971(uc001deh.2) ENST00000540432(uc001dee.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WLS
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate WLS (see all 17):
    hsa-miR-320a hsa-miR-549 hsa-miR-3689b hsa-miR-548v hsa-miR-487a hsa-miR-374c hsa-miR-3121-3p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmid: WLS 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WLS (see all 4)
    OriGene shRNA RFP: WLS
    OriGene siRNA: WLS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WLS
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): WLS (NM_001002292)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WLS

    Additional cDNA sequence: 

    AB097018.1 AK026744.1 AK074583.1 AK074984.1 AK301613.1 AK309779.1 AY359035.1 BC007211.1 
    BC110826.1 BC137109.1 BC137113.1 BX537492.1 BX538320.1 BX648748.1 DQ323735.1 

    24/29 DOTS entries (see all 29):

    DT.100816274  DT.452140  DT.91905099  DT.75181539  DT.441548  DT.91847563  DT.100816275  DT.100665040 
    DT.91751007  DT.100030283  DT.100651273  DT.100030273  DT.121433542  DT.121433560  DT.121433652  DT.121433669 
    DT.121433693  DT.121433702  DT.121433712  DT.100697904  DT.100707831  DT.100733892  DT.121433713  DT.121433723 

    24/278 AceView cDNA sequences (see all 278):

    BM918415 BU855502 BP350160 BQ890487 AL547185 BM710310 AI338593 AJ709703 
    CR591378 NM_001002292 BQ669223 CA438784 BX491442 AW000899 AK026744 BU553679 
    CO248647 BG546588 CA397238 BM476297 BQ883405 BQ026375 AI569625 BU844812 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WLS (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                -           -     -     -                                                                                             
    SP2:                                -     -     -     -     -                                                                                             
    SP3:                                                                                                                                            -         
    SP4:        -     -     -     -     -           -     -     -                                                                                             
    SP5:              -     -     -     -           -     -     -                                                                                             


    ECgene alternative splicing isoforms for WLS

    Expression
    for WLS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WLS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAAGATTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WLS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Midbrain dopaminergic-like neurons (Generation of midbra...)
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
    Definitive endoderm-like cells (Generation of mesend...)
    Posterior foregut-like cells (A scalable, suspensi...)
    Mesoderm-like cells (Derivation of cardio...)

    See WLS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WLS

    SOURCE GeneReport for Unigene cluster: Hs.647659
        SABiosciences Custom PCR Arrays for WLS
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    In Situ
    Assay Products:     
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    Orthologs
    for WLS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WLS gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Wls1 , 5 wntless homolog (Drosophila)1, 5 89.65(n)1
    96.12(a)1    		   3 (82.65 cM)5
    681511  NM_026582.41  NP_080858.31 
     1598396955 
    chicken
    (Gallus gallus)    		 Aves WLS1 wntless homolog (Drosophila) 79.85(n)
    87.8(a)    		   424707  NM_001031294.1  NP_001026465.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WLS6
    		 --
    		 80(a)
    		 1 ↔ 1
    		 GL343328.1(304288-347531)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.114872 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_079187.1 (H.sapiens) hypothetical protein FLJ23091 [Homo sapiens] less 78.64(n)    BU915610.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii idibd20102 Danio rerio cDNA clone MGC64091 IMAGE6794921, complete cds less 75.97(n)    BC053246.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta wls1 wntless 53.26(n)
    45.11(a)    		   39259  NM_168450.2  NP_729681.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea mig-141 Protein MIG-14 51.12(n)
    40.73(a)    		   175020  NM_001027104.1  NP_001022275.1 


    ENSEMBL Gene Tree for WLS (if available)
    TreeFam Gene Tree for WLS (if available) 

    Paralogs
    for WLS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for WLS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2676 NCBI SNPs in WLS are shown (see all 2676)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1428316821,2
    		--68563720(+) CCACTA/GTGGTC 2 -- int10--------
    rs1914191971,2
    		--68563760(+) TCGGTC/GCTGCA 2 -- int10--------
    rs772555901,2
    		C,--68563777(+) CACTGC/TCTTAG 2 -- int13Minor allele frequency- T:0.05CSA WA NA 240
    rs1830243361,2
    		--68563786(+) AGTACG/TTCTCA 2 -- int10--------
    rs171304601,2
    		C,F,H,--68563807(+) TGAAGC/TTGGGA 2 -- int116Minor allele frequency- T:0.04NA NS EA WA 1756
    rs1460927051,2
    		--68564009(+) ATGGAA/GGATAA 2 -- int10--------
    rs1885134891,2
    		--68564027(+) AAAAGA/TAATTT 2 -- int10--------
    rs120926021,2
    		--68564037(+) tgtaaC/Taaaat 2 -- int12Minor allele frequency- T:0.04CSA WA 120
    rs1922377911,2
    		--68564040(+) AACAAA/CATAAT 2 -- int10--------
    rs1398385331,2
    		--68564123(+) ACATAC/TATTGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for WLS (68564142 - 68698803 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for WLS: --

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    Disorders / Diseases
    for WLS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WLS for disorders           About GeneDecksing

    OMIM gene information: 611514    OMIM disorders: --

    3 diseases for WLS:    About MalaCards
    focal dermal hypoplasia    chronic intestinal vascular insufficiency    osteoporosis

    1 disease from the University of Copenhagen DISEASES database for WLS:
    Focal dermal hypoplasia
    Human Genome Epidemiology (HuGE) Navigator: WLS (4 documents)

    Export disorders for WLS gene to outside databases

    Publications
    for WLS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WLS gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with WLS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. (PubMed id 16678095)1, 2 Baenziger C....Basler K. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 3 Matsuda A....Sugano S. (2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (PubMed id 22837378)1 Wilk J.B....Stricker B.H. (2012)
    8. The Wnt secretion protein Evi/Gpr177 promotes glioma t umourigenesis. (PubMed id 22147553)1 Augustin I....Boutros M. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Identification of an endocytosis motif in an intracell ular loop of Wntless protein, essential for its recycling and the control of Wnt protein signaling. (PubMed id 22027831)1 Gasnereau I....Gleeson P.A. (2011)

    External Searches for WLS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WLS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79971 HGNC: 30238 AceView: FLJ23091 Ensembl:ENSG00000116729 euGenes: HUgn79971
    ECgene: WLS H-InvDB: WLS

    Other Databases showing WLS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WLS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WLS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WLS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WLS gene:
    Search GeneIP for patents involving WLS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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