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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WLS Gene

protein-coding   GIFtS: 58
GCID: GC01M068564

Wntless Wnt Ligand Secretion Mediator

(Previous names: chromosome 1 open reading frame 139, G protein-coupled receptor...)
(Previous symbols: C1orf139, GPR177)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Wntless Wnt Ligand Secretion Mediator1     Putative NF-Kappa-B-Activating Protein 3732 3
GPR1771 2 3 5     Chromosome 1 Open Reading Frame 1391
C1orf1391 2 3     Wntless Homolog1
EVI2 3 5     MRP2
G Protein-Coupled Receptor 1771 2     mig-142
Wntless Homolog (Drosophila)1 2     Protein Wntless Homolog2
Integral Membrane Protein GPR1772 3     Putative NFkB Activating Protein 3732
Protein Evenness Interrupted Homolog2 3     

External Ids:    HGNC: 302381   Entrez Gene: 799712   Ensembl: ENSG000001167297   OMIM: 6115145   UniProtKB: Q5T9L33   

Export aliases for WLS gene to outside databases

Previous GC identifer: GC01M066674


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WLS Gene: 
WLS (wntless Wnt ligand secretion mediator) is a protein-coding gene. Diseases associated with WLS include chronic intestinal vascular insufficiency, and focal dermal hypoplasia, and among its related super-pathways are Asparagine N-linked glycosylation and Signaling by GPCR. GO annotations related to this gene include Wnt-protein binding and signal transducer activity.

UniProtKB/Swiss-Prot: WLS_HUMAN, Q5T9L3
Function: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal
interaction plays a key role in the regulation of expression, subcellular location, binding and
organelle-specific association of Wnt proteins. Plays also an important role in establishment of the
anterior-posterior body axis formation during development (By similarity)

Gene Wiki entry for WLS (GPR177) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for WLS
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWLS promoter sequence
   Search SABiosciences Chromatin IP Primers for WLS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WLS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.2

WLS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WLS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M068564:  view genomic region     (about GC identifiers)

Start:
68,564,142 bp from pter      End:
68,698,803 bp from pter
Size:
134,662 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WLS_HUMAN, Q5T9L3 (See protein sequence)
Recommended Name: Protein wntless homolog precursor  
Size: 541 amino acids; 62253 Da
Subunit: Interacts with WNT3A. Interacts with WNT1, WNT3 and WNT5A (By similarity)
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane;
Multi-pass membrane protein
Secondary accessions: B2RNT2 Q5JRS7 Q7Z2Z9 Q8NC43
Alternative splicing: 3 isoforms:  Q5T9L3-1   Q5T9L3-2   Q5T9L3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WLS: NX_Q5T9L3

Explore proteomics data for WLS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T9L3

  • WLS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WLS Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001002292.3  NP_001180263.1  NP_079187.3  

    ENSEMBL proteins: 
     ENSP00000346829   ENSP00000262348   ENSP00000360015   ENSP00000431552   ENSP00000433690  
     ENSP00000433111   ENSP00000360012   ENSP00000436196   ENSP00000433188   ENSP00000433867  
     ENSP00000360010   ENSP00000446112  
    Reactome Protein details: Q5T9L3
    Human Recombinant Protein Products for WLS: 
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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals WLS Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WLS 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--

    WLS for ontologies           About GeneDecksing



    WLS Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for WLS 

    Assay Products for WLS: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009551 Wntless

    Graphical View of Domain Structure for InterPro Entry Q5T9L3

    ProtoNet protein and cluster: Q5T9L3

    UniProtKB/Swiss-Prot: WLS_HUMAN, Q5T9L3
    Similarity: Belongs to the wntless family


    WLS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WLS_HUMAN, Q5T9L3
    Function: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal
    interaction plays a key role in the regulation of expression, subcellular location, binding and
    organelle-specific association of Wnt proteins. Plays also an important role in establishment of the
    anterior-posterior body axis formation during development (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity ISS--
    GO:0005515protein binding IPI--
    GO:0017147Wnt-protein binding IEA--
         
    WLS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WLS:
     Decreased viability with pacli 

         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Wls):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  integument  limbs/digits/tail  mortality/aging  muscle 
     nervous system  skeleton 

    WLS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wlstm1.2Whsu for WLS

       inGenious Targeting Laboratory - Custom generated mouse model solutions for WLS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WLS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WLS 
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    hsa-miR-320a hsa-miR-549 hsa-miR-3689b hsa-miR-548v hsa-miR-487a hsa-miR-374c hsa-miR-3121-3p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidWLS 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WLS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WLS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    WNT ligand biogenesis and trafficking0.77
    Signaling by Wnt0.62
    2Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for WLS
        Signaling by Wnt
    Signal Transduction
    WNT ligand biogenesis and trafficking



    WLS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WLS

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for WLS (Q5T9L31, 3 ENSP000003468294) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OPRM1P353721, ENSP000003946244EBI-2868748,EBI-2624570 STRING: ENSP00000394624
    MAN1A2O604763I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    C15orf39ENSP000003538544STRING: ENSP00000353854
    GOLGA7BENSP000003596344STRING: ENSP00000359634
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001707mesoderm formation IEA--
    GO:0009948anterior/posterior axis specification IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade ISS--
    GO:0090263positive regulation of canonical Wnt receptor signaling pathway IMP17804805

    WLS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WLS

    Search CenterWatch for drugs/clinical trials and news about WLS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WLS gene (3 alternative transcripts): 
    NM_001002292.3  NM_001193334.1  NM_024911.6  

    Unigene Cluster for WLS:

    Wntless homolog (Drosophila)
    Hs.647659  [show with all ESTs]
    Unigene Representative Sequence: BX537492
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354777(uc021oor.1) ENST00000262348(uc009wbf.1 uc001def.2 uc001deg.2)
    ENST00000370976 ENST00000498615 ENST00000491811 ENST00000497187 ENST00000534713
    ENST00000533537 ENST00000530486 ENST00000370973 ENST00000471243 ENST00000491076
    ENST00000527864 ENST00000370971(uc001deh.2) ENST00000540432(uc001dee.3)

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate WLS (see all 17):
    hsa-miR-320a hsa-miR-549 hsa-miR-3689b hsa-miR-548v hsa-miR-487a hsa-miR-374c hsa-miR-3121-3p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidWLS 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB097018.1 AK026744.1 AK074583.1 AK074984.1 AK301613.1 AK309779.1 AY359035.1 BC007211.1 
    BC110826.1 BC137109.1 BC137113.1 BX537492.1 BX538320.1 BX648748.1 DQ323735.1 

    24/29 DOTS entries (see all 29):

    DT.100816274  DT.452140  DT.91905099  DT.75181539  DT.441548  DT.91847563  DT.100816275  DT.100665040 
    DT.91751007  DT.100030283  DT.100651273  DT.100030273  DT.121433542  DT.121433560  DT.121433652  DT.121433669 
    DT.121433693  DT.121433702  DT.121433712  DT.100697904  DT.100707831  DT.100733892  DT.121433713  DT.121433723 

    24/278 AceView cDNA sequences (see all 278):

    BM476297 BM727984 BQ669223 CR591378 AW964580 CA398257 BM738106 NM_024911 
    AV725885 BM918415 CR624611 AI569625 BM710310 AJ709703 AK026744 NM_001002292 
    AA662710 CO248647 BM757304 BQ026375 BQ674607 BE018698 CA434993 BP342897 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WLS (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                -           -     -     -                                                                                             
    SP2:                                -     -     -     -     -                                                                                             
    SP3:                                                                                                                                            -         
    SP4:        -     -     -     -     -           -     -     -                                                                                             
    SP5:              -     -     -     -           -     -     -                                                                                             


    ECgene alternative splicing isoforms for WLS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WLS expression in normal human tissues (normalized intensities)      WLS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGATTTA
    WLS Expression
    About this image


    WLS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Thalamus
             N2/LSB/S/F8/CHIR-induced cells ( Generation of midbrain dopaminergic, forebrain and...
             brain/forebrain   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
     
     Hair
             Primary Hair Placode Cells Hair Follicle
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Intermediate Keratinocytes Embryonic Epidermis
     
     Mesoderm (Gastrulation Derivatives)
             Mesoderm-like cells ( Derivation of cardiomyocytes from pluripotent stem cells and...

    See WLS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WLS

    SOURCE GeneReport for Unigene cluster: Hs.647659
        SABiosciences Custom PCR Arrays for WLS
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WLS gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wls1 , 5 wntless homolog (Drosophila)1, 5 89.65(n)1
    96.12(a)1
      3 (82.65 cM)5
    681511  NM_026582.41  NP_080858.31 
     1598396955 
    chicken
    (Gallus gallus)
    Aves WLS1 wntless homolog (Drosophila) 79.85(n)
    87.8(a)
      424707  NM_001031294.1  NP_001026465.1 
    lizard
    (Anolis carolinensis)
    Reptilia WLS6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL343328.1(302251-347781)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114872 Xenopus laevis transcribed sequence with moderate similarity more 78.64(n)    BU915610.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd20102 Danio rerio cDNA clone MGC64091 IMAGE6794921, complete more 75.97(n)    BC053246.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wls1 wntless 53.26(n)
    45.11(a)
      39259  NM_168450.2  NP_729681.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mig-141 Protein MIG-14 51.12(n)
    40.73(a)
      175020  NM_001027104.1  NP_001022275.1 


    ENSEMBL Gene Tree for WLS (if available)
    TreeFam Gene Tree for WLS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WLS gene
    1 SIMAP similar gene for WLS using alignment to 11 protein entries:     WLS_HUMAN (see all proteins):
    GPR177

    WLS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/550 SNPs in WLS are shown (see all 550)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0299914
    ----see VAR_0299912 V I mis40--------
    rs710649851,2
    C--66807577(-) GCTCG-/CCC   
       
    /CCCC
    CCCCC
    6 -- int1 cds11NA 2
    rs28205051,2
    C,F,O,H--68669204(+) ACAGAG/ATACCT 3 -- int16Minor allele frequency- A:0.05NS EA CSA WA 532
    rs1394701861,2
    --68669298(+) TTACCA/GGGTCT 3 -- int10--------
    rs1814540821,2
    --68669366(+) CTGACC/TCAGGA 3 -- int10--------
    rs28205061,2
    C,F,O,H--68669403(+) ACAGCA/GCTTGC 3 -- int16Minor allele frequency- G:0.05NS EA CSA WA 538
    rs25667501,2
    C,F,A,H--68669479(-) ATTATA/CAGTAA 3 -- int18Minor allele frequency- C:0.07NS EA WA CSA NA 660
    rs1134054331,2
    F--68669515(+) TTGACC/TCAGGA 3 -- int12Minor allele frequency- T:0.33CSA 3
    rs28205071,2
    C,F,O,A,H--68669537(+) CCTCAA/TCCATG 3 -- int111Minor allele frequency- T:0.06NA NS EA WA CSA 788
    rs27722921,2
    C,F,O,H--68669632(-) GCATGG/AATAGG 3 -- int17Minor allele frequency- A:0.08NS EA WA CSA 540

    HapMap Linkage Disequilibrium report for WLS (68564142 - 68698803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for WLS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749475CNV Deletion23290073
    esv2749463CNV Deletion23290073
    esv2672790CNV Deletion23128226
    nsv522414CNV Loss19592680
    nsv522557CNV Loss19592680
    nsv518820CNV Loss19592680
    nsv517355CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611514    OMIM disorders: --

    2 diseases for WLS:    About MalaCards
    chronic intestinal vascular insufficiency    focal dermal hypoplasia

    1 disease from the University of Copenhagen DISEASES database for WLS:
    Focal dermal hypoplasia

    WLS for disorders           About GeneDecksing

    Genetic Association Database (GAD): WLS
    Human Genome Epidemiology (HuGE) Navigator: WLS (4 documents)

    Export disorders for WLS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WLS gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with WLS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Twenty bone-mineral-density loci identified by large- scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1, 4 Rivadeneira F....Uitterlinden A.G. (2009)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. (PubMed id 16678095)1, 2 Baenziger C....Basler K. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 3 Matsuda A....Sugano S. (2003)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. WLS inhibits melanoma cell proliferation through the b -catenin signalling pathway and induces spontaneous metastasis. (PubMed id 23129487)1 Yang P.T....Moon R.T. (2012)
    9. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (PubMed id 22837378)1 Wilk J.B....Stricker B.H. (2012)
    10. The Wnt secretion protein Evi/Gpr177 promotes glioma t umourigenesis. (PubMed id 22147553)1 Augustin I....Boutros M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79971 HGNC: 30238 AceView: FLJ23091 Ensembl:ENSG00000116729 euGenes: HUgn79971
    ECgene: WLS H-InvDB: WLS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WLS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WLS gene:
    Search GeneIP for patents involving WLS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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