Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WLS Gene

Aliases for WLS Gene

  • Wntless Wnt Ligand Secretion Mediator 2 3
  • GPR177 3 4 6
  • EVI 3 4 6
  • Putative NF-Kappa-B-Activating Protein 373 3 4
  • Protein Evenness Interrupted Homolog 3 4
  • Integral Membrane Protein GPR177 3 4
  • G Protein-Coupled Receptor 177 2 3
  • C1orf139 3 4
  • Putative NFkB Activating Protein 373 3
  • Chromosome 1 Open Reading Frame 139 2
  • Wntless Homolog (Drosophila) 2
  • Protein Wntless Homolog 3
  • Wntless Homolog 2
  • Mig-14 3
  • MRP 3

External Ids for WLS Gene

Previous Symbols for WLS Gene

  • C1orf139
  • GPR177

Summaries for WLS Gene

GeneCards Summary for WLS Gene

WLS (Wntless Wnt Ligand Secretion Mediator) is a Protein Coding gene. Diseases associated with WLS include focal dermal hypoplasia. Among its related pathways are Signaling by GPCR and beta-catenin independent WNT signaling. GO annotations related to this gene include signal transducer activity and Wnt-protein binding.

UniProtKB/Swiss-Prot for WLS Gene

  • Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Gene Wiki entry for WLS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WLS Gene

Genomics for WLS Gene

Genomic Location for WLS Gene

Start:
68,098,459 bp from pter
End:
68,233,120 bp from pter
Size:
134,662 bases
Orientation:
Minus strand

Genomic View for WLS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WLS Gene

No data available for Regulatory Elements for WLS Gene

Proteins for WLS Gene

  • Protein details for WLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9L3-WLS_HUMAN
    Recommended name:
    Protein wntless homolog
    Protein Accession:
    Q5T9L3
    Secondary Accessions:
    • B2RNT2
    • Q5JRS7
    • Q7Z2Z9
    • Q8NC43

    Protein attributes for WLS Gene

    Size:
    541 amino acids
    Molecular mass:
    62253 Da
    Quaternary structure:
    • Interacts with WNT3A. Interacts with WNT1, WNT3 and WNT5A (By similarity).

    Alternative splice isoforms for WLS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WLS Gene

Proteomics data for WLS Gene at MOPED

Post-translational modifications for WLS Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys73, Lys217, and Lys419

No data available for DME Specific Peptides for WLS Gene

Domains for WLS Gene

Protein Domains for WLS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WLS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T9L3

UniProtKB/Swiss-Prot:

WLS_HUMAN
Family:
  • Belongs to the wntless family.:
    • Q5T9L3
genes like me logo Genes that share domains with WLS: view

No data available for Gene Families for WLS Gene

Function for WLS Gene

Molecular function for WLS Gene

UniProtKB/Swiss-Prot Function: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Gene Ontology (GO) - Molecular Function for WLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity ISS --
GO:0005515 protein binding IPI 20214800
GO:0017147 Wnt-protein binding IEA --
GO:0031852 mu-type opioid receptor binding IEA --
genes like me logo Genes that share ontologies with WLS: view
genes like me logo Genes that share phenotypes with WLS: view

Animal Models for WLS Gene

MGI Knock Outs for WLS:
  • Wls tm1.2Whsu

miRNA for WLS Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WLS Gene

Localization for WLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for WLS Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WLS Gene COMPARTMENTS Subcellular localization image for WLS gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for WLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with WLS: view

Pathways for WLS Gene

genes like me logo Genes that share pathways with WLS: view

Pathways by source for WLS Gene

Gene Ontology (GO) - Biological Process for WLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001707 mesoderm formation IEA --
GO:0009948 anterior/posterior axis specification IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS --
GO:0090263 positive regulation of canonical Wnt signaling pathway IMP 17804805
genes like me logo Genes that share ontologies with WLS: view

Transcripts for WLS Gene

Unigene Clusters for WLS Gene

Wntless homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WLS Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - -
SP7:
SP8: -

Relevant External Links for WLS Gene

GeneLoc Exon Structure for
WLS
ECgene alternative splicing isoforms for
WLS

Expression for WLS Gene

mRNA expression in normal human tissues for WLS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WLS Gene

SOURCE GeneReport for Unigene cluster for WLS Gene Hs.647659

genes like me logo Genes that share expressions with WLS: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WLS Gene

Orthologs for WLS Gene

This gene was present in the common ancestor of animals.

Orthologs for WLS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WLS 35
  • 99.19 (n)
  • 98.79 (a)
WLS 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WLS 35
  • 93.04 (n)
  • 98.15 (a)
WLS 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WLS 35
  • 89.03 (n)
  • 96.3 (a)
WLS 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wls 35
  • 89.65 (n)
  • 96.12 (a)
Wls 16
Wls 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WLS 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WLS 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wls 35
  • 89.71 (n)
  • 95.75 (a)
chicken
(Gallus gallus)
Aves WLS 35
  • 79.85 (n)
  • 87.8 (a)
WLS 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WLS 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11487 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1995 35
wls 35
  • 71.35 (n)
  • 74.49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12186 35
zebrafish
(Danio rerio)
Actinopterygii idibd2010 35
wls 35
  • 74.43 (n)
  • 78.19 (a)
wls 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007896 35
  • 55.47 (n)
  • 47.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta wls 35
  • 53.26 (n)
  • 45.11 (a)
wls 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mig-14 35
  • 51.08 (n)
  • 40.65 (a)
mig-14 36
  • 36 (a)
OneToOne
Species with no ortholog for WLS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WLS Gene

ENSEMBL:
Gene Tree for WLS (if available)
TreeFam:
Gene Tree for WLS (if available)

Paralogs for WLS Gene

genes like me logo Genes that share paralogs with WLS: view

No data available for Paralogs for WLS Gene

Variants for WLS Gene

Sequence variations from dbSNP and Humsavar for WLS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs989840 -- 68,215,560(-) TCTTA(A/G)GTAAA intron-variant
rs989841 -- 68,215,535(-) TTTAA(A/G)GATTT intron-variant
rs989842 -- 68,215,246(-) TCTTG(A/G)AGATT intron-variant
rs989843 -- 68,215,230(-) AAGAA(A/G)GAAGA intron-variant
rs1036064 -- 68,220,981(-) TCCCC(C/T)ACCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WLS Gene

Variant ID Type Subtype PubMed ID
nsv517355 CNV Gain+Loss 19592680
nsv522414 CNV Loss 19592680
esv2749463 CNV Deletion 23290073
esv2749475 CNV Deletion 23290073
esv2672790 CNV Deletion 23128226
nsv522557 CNV Loss 19592680
nsv518820 CNV Loss 19592680

Relevant External Links for WLS Gene

HapMap Linkage Disequilibrium report
WLS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WLS Gene

Disorders for WLS Gene

(1) MalaCards Diseases for WLS Gene

Search for WLS Gene in MalaCards »

(1) University of Copenhagen DISEASES for WLS Gene

Relevant External Links for WLS

Genetic Association Database (GAD)
WLS
Human Genome Epidemiology (HuGE) Navigator
WLS
genes like me logo Genes that share disorders with WLS: view

No data available for UniProtKB/Swiss-Prot for WLS Gene

Publications for WLS Gene

  1. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F. … Uitterlinden A.G. (Nat. Genet. 2009) 3 48
  2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 2 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for WLS Gene

Sources for WLS Gene

Back to Top

Content