Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



WLS Gene

protein-coding   GIFtS: 59
GCID: GC01M068564

Wntless Wnt Ligand Secretion Mediator

(Previous names: chromosome 1 open reading frame 139, G protein-coupled receptor...)
(Previous symbols: C1orf139, GPR177)
  See WLS-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Wntless Wnt Ligand Secretion Mediator1 2     Chromosome 1 Open Reading Frame 1391
GPR1771 2 3 5     Wntless Homolog1
C1orf1391 2 3     Wntless Homolog (Drosophila)1
EVI2 3 5     MRP2
G Protein-Coupled Receptor 1771 2     mig-142
Integral Membrane Protein GPR1772 3     Protein Wntless Homolog2
Protein Evenness Interrupted Homolog2 3     Putative NFkB Activating Protein 3732
Putative NF-Kappa-B-Activating Protein 3732 3     

External Ids:    HGNC: 302381   Entrez Gene: 799712   Ensembl: ENSG000001167297   OMIM: 6115145   UniProtKB: Q5T9L33   

Export aliases for WLS gene to outside databases

Previous GC identifer: GC01M066674


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for WLS Gene:
WLS (wntless Wnt ligand secretion mediator) is a protein-coding gene. Diseases associated with WLS include focal dermal hypoplasia. GO annotations related to this gene include Wnt-protein binding and signal transducer activity.

UniProtKB/Swiss-Prot: WLS_HUMAN, Q5T9L3
Function: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal
interaction plays a key role in the regulation of expression, subcellular location, binding and
organelle-specific association of Wnt proteins. Plays also an important role in establishment of the
anterior-posterior body axis formation during development (By similarity)

Gene Wiki entry for WLS (GPR177) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Search for regulatory transcription factor binding sites for WLS
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWLS promoter sequence
   Search Chromatin IP Primers for WLS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WLS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.2

WLS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WLS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M068564:  view genomic region     (about GC identifiers)

Start:
68,564,142 bp from pter      End:
68,698,803 bp from pter
Size:
134,662 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: WLS_HUMAN, Q5T9L3 (See protein sequence)
Recommended Name: Protein wntless homolog precursor  
Size: 541 amino acids; 62253 Da
Subunit: Interacts with WNT3A. Interacts with WNT1, WNT3 and WNT5A (By similarity)
Secondary accessions: B2RNT2 Q5JRS7 Q7Z2Z9 Q8NC43
Alternative splicing: 3 isoforms:  Q5T9L3-1   Q5T9L3-2   Q5T9L3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WLS: NX_Q5T9L3

Explore proteomics data for WLS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys73, Lys217, Lys419
  • Modification sites at PhosphoSitePlus

  • See WLS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001002292.3  NP_001180263.1  NP_079187.3  

    ENSEMBL proteins: 
     ENSP00000346829   ENSP00000262348   ENSP00000360015   ENSP00000431552   ENSP00000433690  
     ENSP00000433111   ENSP00000360012   ENSP00000436196   ENSP00000433188   ENSP00000433867  
     ENSP00000360010   ENSP00000446112  
    Reactome Protein details: Q5T9L3

    WLS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for WLS
    GenScript Custom Purified and Recombinant Proteins Services for WLS
    Novus Biologicals WLS Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for WLS
    Cloud-Clone Corp. Proteins for WLS

     
    Search eBioscience for Proteins for WLS 

     
    antibodies-online proteins for WLS (3 products) 

     
    antibodies-online peptides for WLS

    WLS Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of WLS
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WLS
    Novus Biologicals WLS Antibody
    Search for Antibodies for WLS at Abcam
    Cloud-Clone Corp. Antibodies for WLS
    Search ThermoFisher Antibodies for WLS
    antibodies-online antibodies for WLS (8 products) 

    WLS Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WLS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WLS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WLS
    Cloud-Clone Corp. CLIAs for WLS
    Search eBioscience for ELISAs for WLS 
    antibodies-online kits for WLS (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR009551 Wntless

    Graphical View of Domain Structure for InterPro Entry Q5T9L3

    ProtoNet protein and cluster: Q5T9L3

    UniProtKB/Swiss-Prot: WLS_HUMAN, Q5T9L3
    Similarity: Belongs to the wntless family


    Find genes that share domains with WLS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WLS_HUMAN, Q5T9L3
    Function: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal
    interaction plays a key role in the regulation of expression, subcellular location, binding and
    organelle-specific association of Wnt proteins. Plays also an important role in establishment of the
    anterior-posterior body axis formation during development (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity ISS--
    GO:0005515protein binding IPI--
    GO:0017147Wnt-protein binding IEA--
         
    Find genes that share ontologies with WLS           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WLS:
     Decreased viability with pacli 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Wls) (see all 20):
     adipose tissue  behavior/neurological  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  mortality/aging 

    Find genes that share phenotypes with WLS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wlstm1.2Whsu for WLS

       genOway: Develop your customized and physiologically relevant rodent model for WLS

    miRNA
    Products:
        
    miRTarBase miRNAs that target WLS:
    hsa-mir-186-5p (MIRT044935), hsa-mir-1 (MIRT023503), hsa-let-7b-5p (MIRT032212), hsa-mir-26b-5p (MIRT028895)

    Block miRNA regulation of human, mouse, rat WLS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WLS (see all 17):
    hsa-miR-320a hsa-miR-549 hsa-miR-3689b hsa-miR-548v hsa-miR-487a hsa-miR-374c hsa-miR-3121-3p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidWLS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WLS
    Predesigned siRNA for gene silencing in human, mouse, rat WLS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WLS

    Clone
    Products:
         
    OriGene clones in human, mouse for WLS (see all 15)
    OriGene ORF clones in mouse, rat for WLS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): WLS (NM_001002292)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WLS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WLS

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WLS
    Browse ESI BIO Cell Lines and PureStem Progenitors for WLS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WLS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    WLS_HUMAN, Q5T9L3: Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane;
    Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--

    Find genes that share ontologies with WLS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for WLS About    
    See pathways by source

    SuperPathContained pathways About
    1beta-catenin independent WNT signaling
    Signaling by Wnt0.79
    2Signaling by GPCR
    Signal Transduction0.58
    3Wnt Pathway
    WNT ligand biogenesis and trafficking0.56


    Find genes that share SuperPaths with WLS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for WLS
        WNT ligand biogenesis and trafficking


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WLS
    Interactions:

        Search GeneGlobe Interaction Network for WLS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for WLS (Q5T9L31, 3 ENSP000003468294) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OPRM1P353721, ENSP000003946244EBI-2868748,EBI-2624570 STRING: ENSP00000394624
    MAN1A2O604763I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    C15orf39ENSP000003538544STRING: ENSP00000353854
    MAN1C1ENSP000003634524STRING: ENSP00000363452
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001707mesoderm formation IEA--
    GO:0009948anterior/posterior axis specification IEA--
    GO:0016055Wnt signaling pathway IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling ISS--
    GO:0090263positive regulation of canonical Wnt signaling pathway IMP17804805

    Find genes that share ontologies with WLS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WLS



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for WLS gene (3 alternative transcripts): 
    NM_001002292.3  NM_001193334.1  NM_024911.6  

    Unigene Cluster for WLS:

    Wntless homolog (Drosophila)
    Hs.647659  [show with all ESTs]
    Unigene Representative Sequence: BX537492
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354777(uc021oor.1) ENST00000262348(uc009wbf.1 uc001def.2 uc001deg.2)
    ENST00000370976 ENST00000498615 ENST00000491811 ENST00000497187 ENST00000534713
    ENST00000533537 ENST00000530486 ENST00000370973 ENST00000471243 ENST00000491076
    ENST00000527864 ENST00000370971(uc001deh.2) ENST00000540432(uc001dee.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WLS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WLS (see all 17):
    hsa-miR-320a hsa-miR-549 hsa-miR-3689b hsa-miR-548v hsa-miR-487a hsa-miR-374c hsa-miR-3121-3p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidWLS 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WLS
    Predesigned siRNA for gene silencing in human, mouse, rat WLS
    Clone
    Products:
         
    OriGene clones in human, mouse for WLS (see all 15)
    OriGene ORF clones in mouse, rat for WLS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): WLS (NM_001002292)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WLS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WLS
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WLS
    OriGene qSTAR qPCR primer pairs in human, mouse for WLS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WLS
      QuantiTect SYBR Green Assays in human, mouse, rat WLS
      QuantiFast Probe-based Assays in human, mouse, rat WLS

    Additional mRNA sequence: 

    AB097018.1 AK026744.1 AK074583.1 AK074984.1 AK301613.1 AK309779.1 AY359035.1 BC007211.1 
    BC110826.1 BC137109.1 BC137113.1 BX537492.1 BX538320.1 BX648748.1 DQ323735.1 

    Selected DOTS entries (see all 29):

    DT.100816274  DT.452140  DT.91905099  DT.75181539  DT.441548  DT.91847563  DT.100816275  DT.100665040 
    DT.91751007  DT.100030283  DT.100651273  DT.100030273  DT.121433542  DT.121433560  DT.121433652  DT.121433669 
    DT.121433693  DT.121433702  DT.121433712  DT.100697904  DT.100707831  DT.100733892  DT.121433713  DT.121433723 

    Selected AceView cDNA sequences (see all 278):

    BU844812 AV725885 BM757304 BG546588 BM727984 BQ423309 NM_001002292 AA662710 
    AL547185 BP350160 NM_024911 AW964580 BQ674607 BP871859 BU932007 BX491442 
    AW000899 AJ709703 AK026744 CR591378 BU855502 CA398257 CA434993 BE018698 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WLS (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                -           -     -     -                                                                                             
    SP2:                                -     -     -     -     -                                                                                             
    SP3:                                                                                                                                            -         
    SP4:        -     -     -     -     -           -     -     -                                                                                             
    SP5:              -     -     -     -           -     -     -                                                                                             


    ECgene alternative splicing isoforms for WLS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    WLS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGATTTA
    WLS Expression
    About this image


    WLS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
             N2/LSB/S/F8/CHIR-induced cells
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             Definitive endoderm-like cells
     
     Neurons
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
             Midbrain dopaminergic-like neurons
     
     Epithelial Cells
             Intermediate Keratinocytes Embryonic Epidermis
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Intermediate Keratinocytes Embryonic Epidermis
    WLS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WLS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647659
        Custom PCR Arrays for WLS
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WLS
    OriGene qSTAR qPCR primer pairs in human, mouse for WLS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WLS
    QuantiTect SYBR Green Assays in human, mouse, rat WLS
    QuantiFast Probe-based Assays in human, mouse, rat WLS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WLS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for WLS gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wls1 , 5 wntless homolog (Drosophila)1, 5 89.65(n)1
    96.12(a)1
      3 (82.65 cM)5
    681511  NM_026582.41  NP_080858.31 
     1598396955 
    chicken
    (Gallus gallus)
    Aves WLS1 wntless homolog (Drosophila) 79.85(n)
    87.8(a)
      424707  NM_001031294.1  NP_001026465.1 
    lizard
    (Anolis carolinensis)
    Reptilia WLS6
    wntless Wnt ligand secretion mediator
    80(a)
    1 ↔ 1
    GL343328.1(302251-347781)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114872 Xenopus laevis transcribed sequence with moderate similarity more 78.64(n)    BU915610.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd20102 Danio rerio cDNA clone MGC64091 IMAGE6794921, complete more 75.97(n)    BC053246.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wls1 wntless 53.26(n)
    45.11(a)
      39259  NM_140188.4  NP_648445.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mig-141 mig-14 51.08(n)
    40.65(a)
      175020  NM_001027104.1  NP_001022275.1 


    ENSEMBL Gene Tree for WLS (if available)
    TreeFam Gene Tree for WLS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for WLS gene
    1 SIMAP similar gene for WLS using alignment to 11 protein entries:     WLS_HUMAN (see all proteins):
    GPR177

    Find genes that share paralogs with WLS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for WLS (see all 550)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710649851,2
    C--66807577(-) GCTCG-/CCC   
       
    /CCCC
    CCCCC
    6 -- int1 cds11NA 2
    rs28205051,2
    C,F,O,H--68669204(+) ACAGAG/ATACCT 3 -- int16Minor allele frequency- A:0.05NS EA CSA WA 532
    rs1394701861,2
    --68669298(+) TTACCA/GGGTCT 3 -- int10--------
    rs1814540821,2
    --68669366(+) CTGACC/TCAGGA 3 -- int10--------
    rs28205061,2
    C,F,O,H--68669403(+) ACAGCA/GCTTGC 3 -- int16Minor allele frequency- G:0.05NS EA CSA WA 538
    rs25667501,2
    C,F,A,H--68669479(-) ATTATA/CAGTAA 3 -- int18Minor allele frequency- C:0.07NS EA WA CSA NA 660
    rs1134054331,2
    F--68669515(+) TTGACC/TCAGGA 3 -- int12Minor allele frequency- T:0.33CSA 3
    rs28205071,2
    C,F,O,A,H--68669537(+) CCTCAA/TCCATG 3 -- int111Minor allele frequency- T:0.06NA NS EA WA CSA 788
    rs27722921,2
    C,F,O,H--68669632(-) GCATGG/AATAGG 3 -- int17Minor allele frequency- A:0.08NS EA WA CSA 540
    rs1478047621,2
    --68669773(+) ATGGTC/TAAAAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for WLS (68564142 - 68698803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for WLS:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749475CNV Deletion23290073
    esv2749463CNV Deletion23290073
    esv2672790CNV Deletion23128226
    nsv522414CNV Loss19592680
    nsv522557CNV Loss19592680
    nsv518820CNV Loss19592680
    nsv517355CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WLS
    DNA2.0 Custom Variant and Variant Library Synthesis for WLS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611514    OMIM disorders: --

    1 disease for WLS:    
    About MalaCards
    focal dermal hypoplasia

    1 disease from the University of Copenhagen DISEASES database for WLS:
    Focal dermal hypoplasia

    Find genes that share disorders with WLS           About GenesLikeMe

    Genetic Association Database (GAD): WLS
    Human Genome Epidemiology (HuGE) Navigator: WLS (4 documents)

    Export disorders for WLS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for WLS gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with WLS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1, 4 Rivadeneira F....Uitterlinden A.G. (Nat. Genet. 2009)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. (PubMed id 16678095)1, 2 Baenziger C....Basler K. (Cell 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 3 Matsuda A....Sugano S. (Oncogene 2003)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Case-control association study of WLS variants in opioid and cocaine addicted populations. (PubMed id 23566366)1 Crist R.C....Berrettini W.H. (Psychiatry Res 2013)
    9. Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development. (PubMed id 23188710)1 Maruyama T....Hsu W. (J. Bone Miner. Res. 2013)
    10. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79971 HGNC: 30238 AceView: FLJ23091 Ensembl:ENSG00000116729 euGenes: HUgn79971
    ECgene: WLS H-InvDB: WLS

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for WLS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for WLS gene:
    Search GeneIP for patents involving WLS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of WLS
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for WLS (GPR177/WLS)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for WLS  
     OriGene qPCR primer pairs and template standards for WLS   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for WLS  
     OriGene qSTAR qPCR primer pairs in human, mouse for WLS   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for WLS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WLS   OriGene Custom Protein Services for WLS  

     
     
     Block miRNA regulation of human, mouse, rat WLS using miScript Target Protectors SeqTarget long-range PCR primers for resequencing WLS
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WLS Predesigned siRNA for gene silencing in human, mouse, rat WLS
     QuantiFast Probe-based Assays in human, mouse, rat WLS QuantiTect SYBR Green Assays in human, mouse, rat WLS
     Custom PCR Arrays for WLS Search Chromatin IP Primers for WLS
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WLS  Search GeneGlobe Interaction Network for WLS
     Search Regulatory tfbs for WLS
     GenScript Custom Purified and Recombinant Proteins Services for WLS GenScript cDNA clones with any tag delivered in your preferred vector for WLS
     GenScript Custom Assay Services for WLS GenScript Custom overexpressing Cell Line Services for WLS
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for WLS
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     WLS antibodies
     WLS proteins
     Search for Antibodies for WLS at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for WLS
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for WLS
     Proteins for WLS
     Antibodies for WLS
     ELISAs for WLS
     CLIAs for WLS



     Browse ESI BIO Cell Lines and PureStem Progenitors for WLS
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WLS
     SwitchGear 3'UTR luciferase reporter plasmids for WLS
     SwitchGear Promoter luciferase reporter plasmids for WLS
     Search ThermoFisher Antibodies for WLS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WLS
     Browse compounds at ApexBio
     Search Addgene for plasmids for WLS
      Search eBioscience for proteins for WLS
      Search eBioscience for elisas for WLS
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for WLS
     antibodies-online antibodies for WLS (8 products)
     antibodies-online kits for WLS (5 products)
     antibodies-online peptides for WLS
     antibodies-online proteins for WLS (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WLS gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4