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Aliases for WLS Gene

Aliases for WLS Gene

  • Wntless Wnt Ligand Secretion Mediator 2 3 5
  • Putative NF-Kappa-B-Activating Protein 373 3 4
  • Protein Evenness Interrupted Homolog 3 4
  • Integral Membrane Protein GPR177 3 4
  • G Protein-Coupled Receptor 177 2 3
  • C1orf139 3 4
  • GPR177 3 4
  • EVI 3 4
  • Putative NFkB Activating Protein 373 3
  • Chromosome 1 Open Reading Frame 139 2
  • Wntless Homolog (Drosophila) 2
  • Wntless Homolog 2
  • Mig-14 3
  • MRP 3

External Ids for WLS Gene

Previous HGNC Symbols for WLS Gene

  • C1orf139
  • GPR177

Previous GeneCards Identifiers for WLS Gene

  • GC01M068564
  • GC01M066674

Summaries for WLS Gene

GeneCards Summary for WLS Gene

WLS (Wntless Wnt Ligand Secretion Mediator) is a Protein Coding gene. Diseases associated with WLS include Chromosome 1P32-P31 Deletion Syndrome and Chronic Intestinal Vascular Insufficiency. Among its related pathways are Signaling by Wnt and WNT ligand biogenesis and trafficking. GO annotations related to this gene include signal transducer activity and mu-type opioid receptor binding.

UniProtKB/Swiss-Prot for WLS Gene

  • Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Gene Wiki entry for WLS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WLS Gene

Genomics for WLS Gene

Regulatory Elements for WLS Gene

Enhancers for WLS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WLS on UCSC Golden Path with GeneCards custom track

Promoters for WLS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WLS on UCSC Golden Path with GeneCards custom track

Genomic Location for WLS Gene

Chromosome:
1
Start:
68,098,459 bp from pter
End:
68,233,120 bp from pter
Size:
134,662 bases
Orientation:
Minus strand

Genomic View for WLS Gene

Genes around WLS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WLS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WLS Gene

Proteins for WLS Gene

  • Protein details for WLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9L3-WLS_HUMAN
    Recommended name:
    Protein wntless homolog
    Protein Accession:
    Q5T9L3
    Secondary Accessions:
    • B2RNT2
    • Q5JRS7
    • Q7Z2Z9
    • Q8NC43

    Protein attributes for WLS Gene

    Size:
    541 amino acids
    Molecular mass:
    62253 Da
    Quaternary structure:
    • Interacts with WNT3A. Interacts with WNT1, WNT3 and WNT5A (By similarity).

    Alternative splice isoforms for WLS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WLS Gene

Proteomics data for WLS Gene at MOPED

Post-translational modifications for WLS Gene

  • Ubiquitination at Lys 73, Lys 217, and Lys 419
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for WLS Gene

Domains & Families for WLS Gene

Protein Domains for WLS Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5T9L3

UniProtKB/Swiss-Prot:

WLS_HUMAN :
  • Belongs to the wntless family.
Family:
  • Belongs to the wntless family.
genes like me logo Genes that share domains with WLS: view

No data available for Gene Families for WLS Gene

Function for WLS Gene

Molecular function for WLS Gene

UniProtKB/Swiss-Prot Function:
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
genes like me logo Genes that share phenotypes with WLS: view

Animal Models for WLS Gene

MGI Knock Outs for WLS:
  • Wls tm1.2Whsu

Animal Model Products

  • Taconic Biosciences Mouse Models for WLS

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WLS Gene

Localization for WLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for WLS Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Note=Co-localizes with the adaptin AP2A2 at distinct punctae. {ECO:0000269 PubMed:18160347}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WLS Gene COMPARTMENTS Subcellular localization image for WLS gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 5
extracellular 4

Gene Ontology (GO) - Cellular Components for WLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 18160348
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016023 cytoplasmic, membrane-bounded vesicle IDA 16678095
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with WLS: view

Pathways & Interactions for WLS Gene

genes like me logo Genes that share pathways with WLS: view

Pathways by source for WLS Gene

Gene Ontology (GO) - Biological Process for WLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA,TAS --
GO:0030901 midbrain development IEA --
GO:0061355 Wnt protein secretion IMP 24768165
GO:0090263 positive regulation of canonical Wnt signaling pathway IMP 17804805
genes like me logo Genes that share ontologies with WLS: view

No data available for SIGNOR curated interactions for WLS Gene

Drugs & Compounds for WLS Gene

No Compound Related Data Available

Transcripts for WLS Gene

Unigene Clusters for WLS Gene

Wntless homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WLS Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - -
SP7:
SP8: -

Relevant External Links for WLS Gene

GeneLoc Exon Structure for
WLS
ECgene alternative splicing isoforms for
WLS

Expression for WLS Gene

mRNA expression in normal human tissues for WLS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WLS Gene

This gene is overexpressed in Ovary (16.0) and Lung (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WLS Gene



SOURCE GeneReport for Unigene cluster for WLS Gene Hs.647659

genes like me logo Genes that share expression patterns with WLS: view

Protein tissue co-expression partners for WLS Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WLS Gene

Orthologs for WLS Gene

This gene was present in the common ancestor of animals.

Orthologs for WLS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WLS 35
  • 93.04 (n)
  • 98.15 (a)
WLS 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WLS 35
  • 89.03 (n)
  • 96.3 (a)
WLS 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wls 35
  • 89.65 (n)
  • 96.12 (a)
Wls 16
Wls 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WLS 35
  • 99.19 (n)
  • 98.79 (a)
WLS 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wls 35
  • 89.71 (n)
  • 95.75 (a)
oppossum
(Monodelphis domestica)
Mammalia WLS 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WLS 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves WLS 35
  • 79.85 (n)
  • 87.8 (a)
WLS 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WLS 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1995 35
wls 35
  • 71.35 (n)
  • 74.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11487 35
zebrafish
(Danio rerio)
Actinopterygii idibd2010 35
wls 35
  • 74.43 (n)
  • 78.19 (a)
wls 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12186 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007896 35
  • 55.47 (n)
  • 47.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta wls 35
  • 53.26 (n)
  • 45.11 (a)
wls 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mig-14 35
  • 51.08 (n)
  • 40.65 (a)
mig-14 36
  • 36 (a)
OneToOne
Species with no ortholog for WLS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WLS Gene

ENSEMBL:
Gene Tree for WLS (if available)
TreeFam:
Gene Tree for WLS (if available)

Paralogs for WLS Gene

genes like me logo Genes that share paralogs with WLS: view

No data available for Paralogs for WLS Gene

Variants for WLS Gene

Sequence variations from dbSNP and Humsavar for WLS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_029991 -
rs989840 -- 68,215,560(-) TCTTA(A/G)GTAAA intron-variant
rs989841 -- 68,215,535(-) TTTAA(A/G)GATTT intron-variant
rs989842 -- 68,215,246(-) TCTTG(A/G)AGATT intron-variant
rs1036064 -- 68,220,981(-) TCCCC(C/T)ACCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WLS Gene

Variant ID Type Subtype PubMed ID
nsv517355 CNV Gain+Loss 19592680
nsv522414 CNV Loss 19592680
esv2749463 CNV Deletion 23290073
esv2749475 CNV Deletion 23290073
esv2672790 CNV Deletion 23128226
nsv522557 CNV Loss 19592680
nsv518820 CNV Loss 19592680

Variation tolerance for WLS Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.74; 86.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WLS Gene

Disorders for WLS Gene

MalaCards: The human disease database

(2) MalaCards diseases for WLS Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 1p32-p31 deletion syndrome
  • 1p31p32 microdeletion syndrome
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
- elite association - COSMIC cancer census association via MalaCards
Search WLS in MalaCards View complete list of genes associated with diseases

Relevant External Links for WLS

Genetic Association Database (GAD)
WLS
Human Genome Epidemiology (HuGE) Navigator
WLS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WLS
genes like me logo Genes that share disorders with WLS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WLS Gene

Publications for WLS Gene

  1. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F. … Uitterlinden A.G. (Nat. Genet. 2009) 3 48 67
  2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 2 3
  3. Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression. (PMID: 25258105) Stewart J. … Salto-Tellez M. (Mod. Pathol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for WLS Gene

Sources for WLS Gene

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