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Aliases for WLS Gene

Aliases for WLS Gene

  • Wntless Wnt Ligand Secretion Mediator 2 3 5
  • Putative NF-Kappa-B-Activating Protein 373 3 4
  • Protein Evenness Interrupted Homolog 3 4
  • Integral Membrane Protein GPR177 3 4
  • G Protein-Coupled Receptor 177 2 3
  • C1orf139 3 4
  • GPR177 3 4
  • EVI 3 4
  • Putative NFkB Activating Protein 373 3
  • Chromosome 1 Open Reading Frame 139 2
  • Wntless Homolog (Drosophila) 2
  • Protein Wntless Homolog 3
  • Wntless Homolog 2
  • Mig-14 3
  • MRP 3

External Ids for WLS Gene

Previous HGNC Symbols for WLS Gene

  • C1orf139
  • GPR177

Previous GeneCards Identifiers for WLS Gene

  • GC01M068564
  • GC01M066674

Summaries for WLS Gene

GeneCards Summary for WLS Gene

WLS (Wntless Wnt Ligand Secretion Mediator) is a Protein Coding gene. Diseases associated with WLS include Chromosome 1P32-P31 Deletion Syndrome and Chronic Intestinal Vascular Insufficiency. Among its related pathways are Signaling by GPCR and WNT ligand biogenesis and trafficking. GO annotations related to this gene include signal transducer activity and mu-type opioid receptor binding.

UniProtKB/Swiss-Prot for WLS Gene

  • Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Gene Wiki entry for WLS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WLS Gene

Genomics for WLS Gene

Regulatory Elements for WLS Gene

Enhancers for WLS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F068255 0.4 Ensembl 19.9 -22.5 -22481 0.4 ZNF316 CEBPB NFE2 EP300 MAFK WLS MIR1262 RPS7P4 COX6B1P7
GH01F068269 0.9 Ensembl ENCODE 13.4 -36.9 -36882 1.6 JUN BHLHE40 TEAD4 CEBPB ZFP37 HIC1 JUND GATA3 FOS RCOR1 WLS COX6B1P7 RPS7P4
GH01F068196 1.4 Ensembl ENCODE 12.1 +34.8 34793 3.4 ELF3 FEZF1 RAD21 RARA YY1 ZNF366 FOS ZNF362 CEBPB ZNF843 WLS GNG12-AS1 GC01P068189 GC01P068203
GH01F068172 1.2 FANTOM5 Ensembl ENCODE 9.2 +56.7 56680 7.6 TBP PKNOX1 INSM2 SIN3A FEZF1 RFX5 GLIS2 ZNF366 SCRT2 RCOR1 WLS RPE65 IL12RB2 MIR1262 CTBP2P8
GH01F068377 0.2 ENCODE 9.1 -145.6 -145589 1.5 JUND ZBTB48 JUN FOS TCF7L2 ZNF558 WLS ENSG00000229440 ELOCP18
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WLS on UCSC Golden Path with GeneCards custom track

Promoters for WLS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000538724 1320 3200 TBP ZNF76 KLF17 SIN3A ZNF2 RAD21 GLIS2 ZNF366 SCRT2 KLF7

Genomic Location for WLS Gene

Chromosome:
1
Start:
68,098,459 bp from pter
End:
68,233,120 bp from pter
Size:
134,662 bases
Orientation:
Minus strand

Genomic View for WLS Gene

Genes around WLS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WLS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WLS Gene

Proteins for WLS Gene

  • Protein details for WLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9L3-WLS_HUMAN
    Recommended name:
    Protein wntless homolog
    Protein Accession:
    Q5T9L3
    Secondary Accessions:
    • B2RNT2
    • Q5JRS7
    • Q7Z2Z9
    • Q8NC43

    Protein attributes for WLS Gene

    Size:
    541 amino acids
    Molecular mass:
    62253 Da
    Quaternary structure:
    • Interacts with WNT3A. Interacts with WNT1, WNT3 and WNT5A (By similarity).

    Alternative splice isoforms for WLS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WLS Gene

Post-translational modifications for WLS Gene

  • Ubiquitination at Lys 73, Lys 217, and Lys 419
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WLS Gene

Domains & Families for WLS Gene

Protein Domains for WLS Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5T9L3

UniProtKB/Swiss-Prot:

WLS_HUMAN :
  • Belongs to the wntless family.
Family:
  • Belongs to the wntless family.
genes like me logo Genes that share domains with WLS: view

No data available for Gene Families for WLS Gene

Function for WLS Gene

Molecular function for WLS Gene

UniProtKB/Swiss-Prot Function:
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Gene Ontology (GO) - Molecular Function for WLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity ISS --
GO:0005515 protein binding IPI 18160348
GO:0017147 Wnt-protein binding IEA,ISS 16678095
GO:0031852 mu-type opioid receptor binding IEA --
genes like me logo Genes that share ontologies with WLS: view
genes like me logo Genes that share phenotypes with WLS: view

Animal Models for WLS Gene

MGI Knock Outs for WLS:
  • Wls tm1.2Whsu

Animal Model Products

  • Taconic Biosciences Mouse Models for WLS

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WLS Gene

Localization for WLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for WLS Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Note=Co-localizes with the adaptin AP2A2 at distinct punctae. {ECO:0000269 PubMed:18160347}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WLS Gene COMPARTMENTS Subcellular localization image for WLS gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 5
extracellular 4

Gene Ontology (GO) - Cellular Components for WLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005768 endosome IEA --
GO:0005769 early endosome IDA 18160348
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with WLS: view

Pathways & Interactions for WLS Gene

genes like me logo Genes that share pathways with WLS: view

Pathways by source for WLS Gene

Gene Ontology (GO) - Biological Process for WLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001707 mesoderm formation IEA --
GO:0006886 intracellular protein transport IMP 16678095
GO:0007275 multicellular organism development IEA --
GO:0009948 anterior/posterior axis specification ISS --
GO:0016055 Wnt signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with WLS: view

No data available for SIGNOR curated interactions for WLS Gene

Transcripts for WLS Gene

Unigene Clusters for WLS Gene

Wntless homolog (Drosophila):
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WLS Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - -
SP7:
SP8: -

Relevant External Links for WLS Gene

GeneLoc Exon Structure for
WLS
ECgene alternative splicing isoforms for
WLS

Expression for WLS Gene

mRNA expression in normal human tissues for WLS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WLS Gene

This gene is overexpressed in Ovary (16.0) and Lung (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WLS Gene



Protein tissue co-expression partners for WLS Gene

NURSA nuclear receptor signaling pathways regulating expression of WLS Gene:

WLS

SOURCE GeneReport for Unigene cluster for WLS Gene:

Hs.647659
genes like me logo Genes that share expression patterns with WLS: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WLS Gene

Orthologs for WLS Gene

This gene was present in the common ancestor of animals.

Orthologs for WLS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WLS 34 35
  • 99.19 (n)
cow
(Bos Taurus)
Mammalia WLS 34 35
  • 93.04 (n)
rat
(Rattus norvegicus)
Mammalia Wls 34
  • 89.71 (n)
mouse
(Mus musculus)
Mammalia Wls 34 16 35
  • 89.65 (n)
dog
(Canis familiaris)
Mammalia WLS 34 35
  • 89.03 (n)
oppossum
(Monodelphis domestica)
Mammalia WLS 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WLS 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves WLS 34 35
  • 79.85 (n)
lizard
(Anolis carolinensis)
Reptilia WLS 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wls 34
  • 71.35 (n)
Str.1995 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11487 34
zebrafish
(Danio rerio)
Actinopterygii wls 34 35
  • 74.43 (n)
idibd2010 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12186 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007896 34
  • 55.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta wls 34 35
  • 53.26 (n)
worm
(Caenorhabditis elegans)
Secernentea mig-14 34 35
  • 51.08 (n)
Species where no ortholog for WLS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WLS Gene

ENSEMBL:
Gene Tree for WLS (if available)
TreeFam:
Gene Tree for WLS (if available)

Paralogs for WLS Gene

genes like me logo Genes that share paralogs with WLS: view

No data available for Paralogs for WLS Gene

Variants for WLS Gene

Sequence variations from dbSNP and Humsavar for WLS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10158351 -- 68,122,085(+) TCTAG(C/T)TTATA intron-variant
rs10158352 -- 68,122,094(+) TAGAT(C/T)CCCCA intron-variant
rs10158359 -- 68,122,200(+) CAGGG(C/T)GTGGC intron-variant
rs1017336 -- 68,124,494(+) TTTCT(C/T)CTTTA intron-variant
rs1017337 -- 68,124,510(+) TATCT(A/C)AAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WLS Gene

Variant ID Type Subtype PubMed ID
esv2672790 CNV deletion 23128226
esv2749463 CNV deletion 23290073
esv2749475 CNV deletion 23290073
esv3563538 CNV deletion 23714750
esv3577910 CNV loss 25503493
nsv1078488 CNV deletion 25765185
nsv477165 CNV novel sequence insertion 20440878
nsv517355 CNV gain+loss 19592680
nsv518820 CNV loss 19592680
nsv522414 CNV loss 19592680
nsv522557 CNV loss 19592680
nsv546448 CNV gain 21841781
nsv945987 CNV duplication 23825009

Variation tolerance for WLS Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.74; 86.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WLS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WLS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WLS Gene

Disorders for WLS Gene

MalaCards: The human disease database

(2) MalaCards diseases for WLS Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 1p32-p31 deletion syndrome
  • 1p31p32 microdeletion syndrome
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
- elite association - COSMIC cancer census association via MalaCards
Search WLS in MalaCards View complete list of genes associated with diseases

Relevant External Links for WLS

Genetic Association Database (GAD)
WLS
Human Genome Epidemiology (HuGE) Navigator
WLS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WLS
genes like me logo Genes that share disorders with WLS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WLS Gene

Publications for WLS Gene

  1. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F. … Uitterlinden A.G. (Nat. Genet. 2009) 3 46 64
  2. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. (PMID: 16678095) Baenziger C. … Basler K. (Cell 2006) 3 4 64
  3. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. (PMID: 16678096) Bartscherer K. … Boutros M. (Cell 2006) 3 4 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for WLS Gene

Sources for WLS Gene

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