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Aliases for WIZ Gene

Aliases for WIZ Gene

  • Widely Interspaced Zinc Finger Motifs 2 3 5
  • Widely-Interspaced Zinc Finger-Containing Protein 3 4
  • Zinc Finger Protein 803 3 4
  • WIZ Zinc Finger 2 3
  • ZNF803 3 4
  • Protein Wiz 3

External Ids for WIZ Gene

Previous GeneCards Identifiers for WIZ Gene

  • GC19M015911
  • GC19M015377
  • GC19M015394
  • GC19M015395
  • GC19M015532
  • GC19M015100

Summaries for WIZ Gene

GeneCards Summary for WIZ Gene

WIZ (Widely Interspaced Zinc Finger Motifs) is a Protein Coding gene. Diseases associated with WIZ include Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex and Asphyxia Neonatorum. GO annotations related to this gene include SET domain binding. An important paralog of this gene is ZNF644.

UniProtKB/Swiss-Prot for WIZ Gene

  • May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).

Additional gene information for WIZ Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIZ Gene

Genomics for WIZ Gene

Regulatory Elements for WIZ Gene

Enhancers for WIZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H014570 1.1 ENCODE 10.8 +878.2 878160 1.8 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 AKAP8 CCDC130 DDX39A DCAF15 BRD4 RFX1 ENSG00000268189 WIZ NDUFB7 DNAJB1
GH19H016063 1.9 FANTOM5 ENCODE dbSUPER 5.4 -623.0 -622958 18.7 FEZF1 DMAP1 ZNF143 SP3 MCM3 MEF2D SSRP1 GLIS1 RCOR2 NBN AKAP8 CHERP ENSG00000269578 BRD4 C19orf44 ENSG00000267904 ENSG00000268087 TPM4 SMIM7 OR10H5
GH19H015222 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.5 +226.2 226244 2.8 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF121 GLIS2 ZNF143 SP3 NFYC NOTCH3 RNU6-782P BRD4 OR10H5 ENSG00000273218 WIZ SYDE1 SLC1A6 ENSG00000269635 EPHX3
GH19H015449 1 ENCODE 0.7 -1.4 -1379 4.2 HDGF PKNOX1 ATF1 SIN3A ZNF2 YY1 ZNF121 GLIS2 FOS KLF7 AKAP8 BRD4 TPM4 RAB8A ZNF333 ENSG00000273218 WIZ RASAL3
GH19H015463 0.8 ENCODE 0.4 -14.3 -14300 2.1 HDGF RAD21 ZNF143 ZNF207 ETV6 RUNX3 CREM IKZF2 SMARCA5 HCFC1 RASAL3 WIZ
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WIZ on UCSC Golden Path with GeneCards custom track

Promoters for WIZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for WIZ Gene

Genomic Locations for WIZ Gene
29,977 bases
Minus strand

Genomic View for WIZ Gene

Genes around WIZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WIZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WIZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIZ Gene

Proteins for WIZ Gene

  • Protein details for WIZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Wiz
    Protein Accession:
    Secondary Accessions:
    • B3KVH1
    • B7ZM82
    • M0QY21
    • Q4G0E0
    • Q6P6B0
    • Q6ZN24
    • Q7LDY6
    • Q7LDZ1
    • Q96IG5
    • Q96SQ6
    • Q9BUR8
    • Q9NPT1

    Protein attributes for WIZ Gene

    1651 amino acids
    Molecular mass:
    178674 Da
    Quaternary structure:
    • Interacts with EHMT1, EHMT2, CTBP1 and CTBP2 (By similarity). Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2.
    • Sequence=BAB55234.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for WIZ Gene


neXtProt entry for WIZ Gene

Post-translational modifications for WIZ Gene

  • Ubiquitination at Lys1597
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WIZ Gene

Domains & Families for WIZ Gene

Gene Families for WIZ Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for WIZ Gene


Graphical View of Domain Structure for InterPro Entry



  • The C2H2-type zinc finger 11 mediates interaction with EHMT1 and EHMT2.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • The C2H2-type zinc finger 11 mediates interaction with EHMT1 and EHMT2.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with WIZ: view

Function for WIZ Gene

Molecular function for WIZ Gene

UniProtKB/Swiss-Prot Function:
May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).

Phenotypes From GWAS Catalog for WIZ Gene

Gene Ontology (GO) - Molecular Function for WIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 16702210
GO:0046872 metal ion binding IEA --
GO:0070984 SET domain binding IEA --
genes like me logo Genes that share ontologies with WIZ: view

Phenotypes for WIZ Gene

genes like me logo Genes that share phenotypes with WIZ: view

Animal Model Products

CRISPR Products

miRNA for WIZ Gene

miRTarBase miRNAs that target WIZ

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WIZ Gene

Localization for WIZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIZ Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WIZ gene
Compartment Confidence
extracellular 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Midbody (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16702210
GO:0005654 nucleoplasm IDA --
GO:0030496 midbody IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with WIZ: view

Pathways & Interactions for WIZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for WIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010571 positive regulation of nuclear cell cycle DNA replication IMP 23545495
GO:0050821 protein stabilization IMP 16702210
GO:0070208 protein heterotrimerization IDA 16702210
genes like me logo Genes that share ontologies with WIZ: view

No data available for Pathways by source and SIGNOR curated interactions for WIZ Gene

Drugs & Compounds for WIZ Gene

No Compound Related Data Available

Transcripts for WIZ Gene

Unigene Clusters for WIZ Gene

Widely interspaced zinc finger motifs:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WIZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: - - - - -
SP4: -

Relevant External Links for WIZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WIZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WIZ Gene

Protein differential expression in normal tissues from HIPED for WIZ Gene

This gene is overexpressed in Heart (31.9) and Peripheral blood mononuclear cells (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WIZ Gene

Protein tissue co-expression partners for WIZ Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WIZ Gene:


SOURCE GeneReport for Unigene cluster for WIZ Gene:


Evidence on tissue expression from TISSUES for WIZ Gene

  • Nervous system(4.5)
  • Skin(4.3)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with WIZ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WIZ Gene

Orthologs for WIZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for WIZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WIZ 33 34
  • 99.15 (n)
(Canis familiaris)
Mammalia WIZ 33 34
  • 89.45 (n)
(Bos Taurus)
Mammalia WIZ 33 34
  • 88.88 (n)
(Rattus norvegicus)
Mammalia Wiz 33
  • 86.79 (n)
(Mus musculus)
Mammalia Wiz 33 16 34
  • 86.46 (n)
(Ornithorhynchus anatinus)
Mammalia WIZ 34
  • 59 (a)
(Monodelphis domestica)
Mammalia WIZ 34
  • 30 (a)
(Gallus gallus)
Aves WIZ 33
  • 69.68 (n)
(Anolis carolinensis)
Reptilia WIZ 34
  • 33 (a)
(Danio rerio)
Actinopterygii WIZ 34
  • 13 (a)
wufi11h08 33
Species where no ortholog for WIZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WIZ Gene

Gene Tree for WIZ (if available)
Gene Tree for WIZ (if available)

Paralogs for WIZ Gene

Paralogs for WIZ Gene Pseudogenes for WIZ Gene

genes like me logo Genes that share paralogs with WIZ: view

Variants for WIZ Gene

Sequence variations from dbSNP and Humsavar for WIZ Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000062281 -- 15,432,526(+) GTGGC(-/GGCGGCGGCGGGGGTGGG)GGCGG intron-variant
rs1000067924 -- 15,436,356(+) GCCTG(G/T)GTTTT intron-variant
rs1000087652 -- 15,446,274(+) GGGCA(C/T)CTGCG intron-variant
rs1000169098 -- 15,429,185(+) CCTCC(C/T)ATCAG intron-variant
rs1000205649 -- 15,434,919(+) ACCTA(C/T)GGTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WIZ Gene

Variant ID Type Subtype PubMed ID
nsv953987 CNV deletion 24416366
nsv833765 CNV loss 17160897
nsv819830 CNV gain 19587683
nsv1118815 CNV deletion 24896259
nsv1064684 CNV gain 25217958

Variation tolerance for WIZ Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WIZ Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIZ Gene

Disorders for WIZ Gene

MalaCards: The human disease database

(4) MalaCards diseases for WIZ Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
bladder exstrophy-epispadias-cloacal exstrophy complex
  • exstrophy-epispadias complex
asphyxia neonatorum
  • asphyxia - birth
exstrophy of bladder
  • bladder exstrophy
kleefstra syndrome
  • 9q subtelomeric deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search WIZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for WIZ

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WIZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WIZ Gene

Publications for WIZ Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Insertional polymorphisms of ETn retrotransposons include a disruption of the wiz gene in C57BL/6 mice. (PMID: 12226707) Baust C … Mager DL (Mammalian genome : official journal of the International Mammalian Genome Society 2002) 2 3 60
  3. Molecular cloning and distinct developmental expression pattern of spliced forms of a novel zinc finger gene wiz in the mouse cerebellum. (PMID: 9795207) Matsumoto K … Tohyama M (Brain research. Molecular brain research 1998) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for WIZ Gene

Sources for WIZ Gene

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