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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WIZ Gene

protein-coding   GIFtS: 45
GCID: GC19M015532

Widely Interspaced Zinc Finger Motifs

(Previous name: WIZ zinc finger)
  Search for WIZ
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Widely Interspaced Zinc Finger Motifs1 2     ZNF8032 3
WIZ Zinc Finger1 2     Protein Wiz2
Widely-Interspaced Zinc Finger-Containing Protein2 3     Widely-Interspaced Zinc Finger Motifs2
Zinc Finger Protein 8032 3     

External Ids:    HGNC: 309171   Entrez Gene: 585252   Ensembl: ENSG000000114517   UniProtKB: O957853   

Export aliases for WIZ gene to outside databases

Previous GC identifers: GC19M015911 GC19M015377 GC19M015394 GC19M015395 GC19M015397 GC19M015100


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WIZ Gene: 
WIZ (widely interspaced zinc finger motifs) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is ZNF644.

UniProtKB/Swiss-Prot: WIZ_HUMAN, O95785
Function: May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved
in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WIZ gene promoter:
         GR   USF1   HTF   GR-beta   AREB6   CP2   USF-1   SEF-1 (1)   GR-alpha   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for WIZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WIZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

WIZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WIZ gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M015532:  view genomic region     (about GC identifiers)

Start:
15,530,792 bp from pter      End:
15,560,762 bp from pter
Size:
29,971 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WIZ_HUMAN, O95785 (See protein sequence)
Recommended Name: Protein Wiz  
Size: 1651 amino acids; 178674 Da
Subunit: Interacts with EHMT1, EHMT2, CTBP1 and CTBP2 (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAB55234.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q4G0E0 Q6P6B0 Q6ZN24 Q7LDY6 Q7LDZ1 Q96IG5 Q96SQ6 Q9BUR8 Q9NPT1
Alternative splicing: 2 isoforms:  O95785-1   O95785-2   

Explore the universe of human proteins at neXtProt for WIZ: NX_O95785

Explore proteomics data for WIZ at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95785

  • WIZ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WIZ Protein Expression
    REFSEQ proteins: NP_067064.2  
    ENSEMBL proteins: 
     ENSP00000263381   ENSP00000469022   ENSP00000469534   ENSP00000471108   ENSP00000469138  
     ENSP00000373933   ENSP00000445824  

    Human Recombinant Protein Products for WIZ: 
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    Novus Biologicals WIZ Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WIZ 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    WIZ for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for WIZ


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O95785

    ProtoNet protein and cluster: O95785

    UniProtKB/Swiss-Prot: WIZ_HUMAN, O95785
    Domain: The C2H2-type zinc finger 11 mediates interaction with EHMT1 and EHMT2 (By similarity)
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers


    WIZ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WIZ_HUMAN, O95785
    Function: May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved
    in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    WIZ for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WIZ:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WIZ 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WIZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WIZ 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIZ


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WIZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/612 Interacting proteins for WIZ (O957852, 3 ENSP000002633814) via UniProtKB, MINT, STRING, and/or I2D (see all 612)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-7945693 MINT-8271696 I2D: score=2 
    SMN2Q166372, 3MINT-7945693 MINT-8271696 I2D: score=2 
    C8orf33Q9H7E92, 3MINT-8250567 I2D: score=2 
    CDKN1AP389362, 3MINT-8252461 I2D: score=2 
    OSGEPQ9NPF42, 3MINT-8265340 I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WIZ

    Search CenterWatch for drugs/clinical trials and news about WIZ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WIZ gene: 
    NM_021241.2  

    Unigene Cluster for WIZ:

    Widely interspaced zinc finger motifs
    Hs.442138  [show with all ESTs]
    Unigene Representative Sequence: NM_021241
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263381(uc002nbb.4) ENST00000599910 ENST00000599686 ENST00000600632
    ENST00000594915 ENST00000595214 ENST00000596159 ENST00000389282(uc002nbc.3 uc002nba.4)
    ENST00000545156
    miRNA
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    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate WIZ (see all 64):
    hsa-miR-194* hsa-miR-132* hsa-miR-3194-5p hsa-miR-1224-3p hsa-miR-1260b hsa-miR-3921 hsa-miR-3162-5p hsa-miR-1304
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WIZ
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    Additional mRNA sequence: 

    AK027615.1 AK091183.1 AK122890.1 AK131404.1 AL390184.1 BC002329.2 BC007551.1 BC014220.2 
    BC048293.1 BC062360.1 BC098445.1 BC136641.1 BC144332.1 

    13 DOTS entries:

    DT.99939435  DT.315030  DT.95272055  DT.433272  DT.99975668  DT.91740999  DT.95148813  DT.95272052 
    DT.95272053  DT.95272054  DT.95272056  DT.97773231  DT.99936404 

    1 AceView cDNA sequence:

    BF111440 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WIZ (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
    SP1:                                            -                                             
    SP2:                    -     -     -     -     -                                             
    SP3:                                                                                          
    SP4:                          -                                                               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for WIZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WIZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAGGCCCC
    WIZ Expression
    About this image


    See WIZ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WIZ

    SOURCE GeneReport for Unigene cluster: Hs.442138
        SABiosciences Custom PCR Arrays for WIZ
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for WIZ gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wiz5 widely-interspaced zinc finger motifs   --   17 (17.52 cM) 32354055 
    chicken
    (Gallus gallus)
    Aves WIZ1 widely interspaced zinc finger motifs 73.16(n)
    72.97(a)
      100858129  XM_003643269.1  XP_003643317.1 
    lizard
    (Anolis carolinensis)
    Reptilia WIZ6
    Uncharacterized protein
    31(a)
    1 ↔ 1
    2(103498862-103526924)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ388189.12   -- 78.85(n)    BQ388189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi11h082 Transcribed sequence with weak similarity to protein more 75.54(n)    CK030367.1 


    ENSEMBL Gene Tree for WIZ (if available)
    TreeFam Gene Tree for WIZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WIZ gene
    ZNF6442  

    WIZ for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WIZ
    PGOHUM00000242614


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/444 SNPs in WIZ are shown (see all 444)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896485841,2
    C--15531876(+) GAGCCA/GAGGTC 1 -- ds50010--------
    rs1416946281,2
    C--15532094(+) CAGGCA/GAGATG 1 -- ds50010--------
    rs1506585401,2
    --15532255(+) CGCCAG/TGAGGT 1 -- ds50010--------
    rs1930850131,2
    --15532268(+) TTCCCA/TCTCTC 1 -- ds50010--------
    rs1858256831,2
    --15532334(+) AGAAGG/TAGCAG 1 -- ut310--------
    rs1899016561,2
    --15532434(+) TCTTTA/TCCCCG 1 -- ut310--------
    rs790221401,2
    C--15532444(+) GCATGC/TTCCTT 1 -- ut310--------
    rs153081,2
    C--15533032(+) CAAAAT/AAAAAA 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs104084671,2
    C--15533042(+) AGATCC/TACGTT 1 -- ut310--------
    rs1814923691,2
    --15533384(+) TGGCAC/TGATGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for WIZ (15530792 - 15560762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for WIZ:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3746n71CNV Loss21882294
    nsv911133CNV Loss21882294
    dgv3747n71CNV Loss21882294
    nsv833765CNV Loss17160897
    nsv819830CNV Gain19587683

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WIZ gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with WIZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Insertional polymorphisms of ETn retrotransposons include a disruption of the wiz gene in C57BL/6 mice. (PubMed id 12226707)1, 3 Baust C....Mager D.L. (2002)
    3. Molecular cloning and distinct developmental expression pattern of spliced forms of a novel zinc finger gene wiz in the mouse cerebellum. (PubMed id 9795207)1, 3 Matsumoto K....Tohyama M. (1998)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58525 HGNC: 30917 AceView: WIZ Ensembl:ENSG00000011451 euGenes: HUgn58525
    ECgene: WIZ H-InvDB: WIZ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WIZ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WIZ gene:
    Search GeneIP for patents involving WIZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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