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Aliases for WIZ Gene

Aliases for WIZ Gene

  • Widely Interspaced Zinc Finger Motifs 2 3
  • Widely-Interspaced Zinc Finger-Containing Protein 3 4
  • Zinc Finger Protein 803 3 4
  • WIZ Zinc Finger 2 3
  • ZNF803 3 4
  • Widely-Interspaced Zinc Finger Motifs 3
  • Protein Wiz 3

External Ids for WIZ Gene

Previous GeneCards Identifiers for WIZ Gene

  • GC19M015911
  • GC19M015377
  • GC19M015394
  • GC19M015395
  • GC19M015532
  • GC19M015100

Summaries for WIZ Gene

GeneCards Summary for WIZ Gene

WIZ (Widely Interspaced Zinc Finger Motifs) is a Protein Coding gene. An important paralog of this gene is ZNF644.

UniProtKB/Swiss-Prot for WIZ Gene

  • May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIZ Gene

Genomics for WIZ Gene

Regulatory Elements for WIZ Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WIZ Gene

15,419,980 bp from pter
15,449,956 bp from pter
29,977 bases
Minus strand

Genomic View for WIZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WIZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIZ Gene

Proteins for WIZ Gene

  • Protein details for WIZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Wiz
    Protein Accession:
    Secondary Accessions:
    • B3KVH1
    • B7ZM82
    • M0QY21
    • Q4G0E0
    • Q6P6B0
    • Q6ZN24
    • Q7LDY6
    • Q7LDZ1
    • Q96IG5
    • Q96SQ6
    • Q9BUR8
    • Q9NPT1

    Protein attributes for WIZ Gene

    1651 amino acids
    Molecular mass:
    178674 Da
    Quaternary structure:
    • Interacts with EHMT1, EHMT2, CTBP1 and CTBP2 (By similarity). Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2.
    • Sequence=BAB55234.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for WIZ Gene


neXtProt entry for WIZ Gene

Proteomics data for WIZ Gene at MOPED

Post-translational modifications for WIZ Gene

  • Ubiquitination at Lys1597
  • Modification sites at PhosphoSitePlus

Other Protein References for WIZ Gene

No data available for DME Specific Peptides for WIZ Gene

Domains for WIZ Gene

Gene Families for WIZ Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for WIZ Gene


Graphical View of Domain Structure for InterPro Entry



  • O95785
  • The C2H2-type zinc finger 11 mediates interaction with EHMT1 and EHMT2.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with WIZ: view

Function for WIZ Gene

Molecular function for WIZ Gene

UniProtKB/Swiss-Prot Function:
May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).

Gene Ontology (GO) - Molecular Function for WIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16702210
GO:0046872 metal ion binding IEA --
GO:0070984 SET domain binding IEA --
genes like me logo Genes that share ontologies with WIZ: view

Phenotypes for WIZ Gene

GenomeRNAi human phenotypes for WIZ:
genes like me logo Genes that share phenotypes with WIZ: view

Animal Model Products

miRNA for WIZ Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WIZ

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WIZ Gene

Localization for WIZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIZ Gene


Subcellular locations from

Jensen Localization Image for WIZ Gene COMPARTMENTS Subcellular localization image for WIZ gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for WIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16702210
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with WIZ: view

Pathways for WIZ Gene

SuperPathways for WIZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for WIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010571 positive regulation of nuclear cell cycle DNA replication IMP 23545495
GO:0050821 protein stabilization IMP 16702210
GO:0070208 protein heterotrimerization IDA 16702210
genes like me logo Genes that share ontologies with WIZ: view

No data available for Pathways by source for WIZ Gene

Transcripts for WIZ Gene

mRNA/cDNA for WIZ Gene

(13) Additional mRNA sequences :
(13) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WIZ Gene

Widely interspaced zinc finger motifs:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WIZ

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WIZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: - - - - -
SP4: -

Relevant External Links for WIZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WIZ Gene

mRNA expression in normal human tissues for WIZ Gene

Protein differential expression in normal tissues for WIZ Gene

This gene is overexpressed in Heart (31.9) and Peripheral blood mononuclear cells (12.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WIZ Gene

SOURCE GeneReport for Unigene cluster for WIZ Gene Hs.442138

genes like me logo Genes that share expressions with WIZ: view

Expression partners for WIZ Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WIZ Gene

Orthologs for WIZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for WIZ Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WIZ 35
  • 88.88 (n)
  • 90.55 (a)
WIZ 36
  • 63 (a)
(Canis familiaris)
Mammalia WIZ 35
  • 89.45 (n)
  • 92.45 (a)
WIZ 36
  • 41 (a)
(Mus musculus)
Mammalia Wiz 35
  • 86.46 (n)
  • 91.68 (a)
Wiz 16
Wiz 36
  • 74 (a)
(Pan troglodytes)
Mammalia WIZ 35
  • 99.15 (n)
  • 99.23 (a)
WIZ 36
  • 44 (a)
(Rattus norvegicus)
Mammalia Wiz 35
  • 86.79 (n)
  • 92.82 (a)
(Monodelphis domestica)
Mammalia WIZ 36
  • 30 (a)
(Ornithorhynchus anatinus)
Mammalia WIZ 36
  • 59 (a)
(Gallus gallus)
Aves WIZ 35
  • 69.68 (n)
  • 67.99 (a)
(Anolis carolinensis)
Reptilia WIZ 36
  • 33 (a)
(Danio rerio)
Actinopterygii wufi11h08 35
WIZ 36
  • 13 (a)
Species with no ortholog for WIZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WIZ Gene

Gene Tree for WIZ (if available)
Gene Tree for WIZ (if available)

Paralogs for WIZ Gene

Paralogs for WIZ Gene Pseudogenes for WIZ Gene

genes like me logo Genes that share paralogs with WIZ: view

Variants for WIZ Gene

Sequence variations from dbSNP and Humsavar for WIZ Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs15308 -- 15,422,221(-) CAAAA(A/T)AAAAA utr-variant-3-prime
rs887898 -- 15,428,628(+) GACTC(A/G)GGCCG intron-variant
rs929613 -- 15,439,128(+) TCCTC(C/T)TCCTC intron-variant, synonymous-codon, reference
rs1005953 -- 15,438,444(+) GCCTT(C/T)ACTGT intron-variant
rs1063168 -- 15,422,241(-) GAGAA(A/T)AAGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WIZ Gene

Variant ID Type Subtype PubMed ID
nsv833765 CNV Loss 17160897
nsv911133 CNV Loss 21882294
dgv3746n71 CNV Loss 21882294
dgv3747n71 CNV Loss 21882294
nsv819830 CNV Gain 19587683

Relevant External Links for WIZ Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIZ Gene

Disorders for WIZ Gene

No disorders were found for WIZ Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for WIZ Gene

Publications for WIZ Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Molecular cloning and distinct developmental expression pattern of spliced forms of a novel zinc finger gene wiz in the mouse cerebellum. (PMID: 9795207) Matsumoto K. … Tohyama M. (Brain Res. Mol. Brain Res. 1998) 2 3
  3. Insertional polymorphisms of ETn retrotransposons include a disruption of the wiz gene in C57BL/6 mice. (PMID: 12226707) Baust C. … Mager D.L. (Mamm. Genome 2002) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Isolation and characterization of a human gene containing a nuclear localization signal from the critical region for velo-cardio-facial syndrome on 22q11. (PMID: 9790763) Funke B. … Morrow B. (Genomics 1998) 3

Products for WIZ Gene

Sources for WIZ Gene

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