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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WISP3 Gene

protein-coding   GIFtS: 56
GCID: GC06P112375

WNT1 Inducible Signaling Pathway Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WNT1 Inducible Signaling Pathway Protein 31 2     PPAC2 5
CCN62 3     PPD2 5
WISP-32 3     LIBC2
CCN Family Member 62 3     WNT1-Inducible-Signaling Pathway Protein 32

External Ids:    HGNC: 127711   Entrez Gene: 88382   Ensembl: ENSG000001127617   OMIM: 6034005   UniProtKB: O953893   

Export aliases for WISP3 gene to outside databases

Previous GC identifers: GC06P112210 GC06P112398 GC06P112420 GC06P112481 GC06P109950


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WISP3 Gene:
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the
connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated
signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by
four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C
module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon
tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation.
Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive
skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage
homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for WISP3 Gene: 
WISP3 (WNT1 inducible signaling pathway protein 3) is a protein-coding gene. Diseases associated with WISP3 include progressive pseudorheumatoid arthropathy of childhood, and arthropathy. GO annotations related to this gene include growth factor activity and insulin-like growth factor binding. An important paralog of this gene is WISP2.

UniProtKB/Swiss-Prot: WISP3_HUMAN, O95389
Function: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis

Gene Wiki entry for WISP3 (WNT1-inducible-signaling pathway protein 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WISP3 gene promoter:
         Pbx1a   GCNF   GCNF-1   SEF-1 (1)   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWISP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for WISP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WISP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

WISP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WISP3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P112375:  view genomic region     (about GC identifiers)

Start:
112,375,275 bp from pter      End:
112,392,171 bp from pter
Size:
16,897 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WISP3_HUMAN, O95389 (See protein sequence)
Recommended Name: WNT1-inducible-signaling pathway protein 3 precursor  
Size: 354 amino acids; 39293 Da
Subcellular location: Secreted (Probable)
Secondary accessions: Q3KR29 Q5H8W4 Q6UXH6
Alternative splicing: 2 isoforms:  O95389-1   O95389-2   

Explore the universe of human proteins at neXtProt for WISP3: NX_O95389

Explore proteomics data for WISP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95389

  • WISP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WISP3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003871.1  NP_937882.1  

    ENSEMBL proteins: 
     ENSP00000357655   ENSP00000473777   ENSP00000395928   ENSP00000357653   ENSP00000357652  
     ENSP00000386467   ENSP00000354734   ENSP00000230529  

    Human Recombinant Protein Products for WISP3: 
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    Novus Biologicals WISP3 Protein
    Novus Biologicals WISP3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WISP3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space NAS9843955

    WISP3 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for WISP3 

    Assay Products for WISP3: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for WISP3 
    Cloud-Clone Corp. CLIAs for WISP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR000884 Thrombospondin_1_rpt
     IPR017891 Insulin_GF-bd_Cys-rich_CS
     IPR006207 Cys_knot_C
     IPR006208 Cys_knot
     IPR000867 IGFBP-like

    Graphical View of Domain Structure for InterPro Entry O95389

    ProtoNet protein and cluster: O95389

    2 Blocks protein domains:
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: WISP3_HUMAN, O95389
    Similarity: Belongs to the CCN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 TSP type-1 domain


    WISP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WISP3_HUMAN, O95389
    Function: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis

         Genatlas biochemistry entry for WISP3:
    WNT1 inducible signaling pathway protein 3,connective tissue growth factor family,CCN family
    (CTGF,IGFBP10,NOU)expressed in adult skeletal muscle,colon,ovary and fetal lung,overexpressed in colon
    tumors,involved in cell growth and differentiation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005520insulin-like growth factor binding IEA--
    GO:0008083growth factor activity IEA--
         
    WISP3 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for WISP3:
     Decreased Wnt reporter activit  Decreased homologous recombina  Decreased viability of wild-ty  G0/1 arrest 
     Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Wisp3):
     normal 

    WISP3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WISP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WISP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WISP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WISP3 

    miRNA
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WISP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WISP3

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0007165signal transduction TAS9843955
    GO:0007267cell-cell signaling TAS9843955

    WISP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WISP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WISP3

    3 Novoseek inferred chemical compound relationships for WISP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanosine 36.5 3 15602803 (2), 14696649 (1)
    cysteine 34.1 1 15579080 (1)
    vegf 4.78 5 14696649 (1), 15602803 (1)

    Search CenterWatch for drugs/clinical trials and news about WISP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WISP3 gene (3 alternative transcripts): 
    NM_003880.3  NM_198239.1  NM_130396.1  

    Unigene Cluster for WISP3:

    WNT1 inducible signaling pathway protein 3
    Hs.558428  [show with all ESTs]
    Unigene Representative Sequence: NM_198239
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368666(uc003pvo.3) ENST00000604763 ENST00000454589(uc003pvm.3 uc003pvn.3)
    ENST00000483439 ENST00000368664 ENST00000368663 ENST00000409166 ENST00000361714
    ENST00000230529
    miRNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene clones in human, mouse for WISP3 (see all 9)
    OriGene ORF clones in mouse, rat for WISP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WISP3 (NM_003880)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WISP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WISP3
    Sirion Biotech Customized lentivirus for stable overexpression of WISP3 
                         Customized lentivirus expression plasmids for stable overexpression of WISP3 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for WISP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat WISP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WISP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WISP3

    Additional mRNA sequence: 

    AB075040.1 AF100781.1 AF143679.1 AY358350.1 BC035250.1 BC102031.1 BC105941.1 

    5 DOTS entries:

    DT.412752  DT.91828965  DT.75196414  DT.101981620  DT.40209954 

    24/30 AceView cDNA sequences (see all 30):

    AW614291 NM_198239 AF143679 AW025138 NM_003880 AY358350 AB075040 AY358349 
    AF100781 NM_130396 AI457678 BG290786 BC035250 CD617639 CD617635 BM715228 
    BC012028 BX281260 CN480250 CD617637 BI492770 AW592899 AI608669 AA592984 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for WISP3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
    SP1:                                -                       -                                       
    SP2:                                                                                                
    SP3:                    -           -                       -                                       
    SP4:                                -                       -                             -         
    SP5:                                      -                 -     -                       -         


    ECgene alternative splicing isoforms for WISP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WISP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGATGGGA
    WISP3 Expression
    About this image


    See WISP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WISP3

    SOURCE GeneReport for Unigene cluster: Hs.558428

    UniProtKB/Swiss-Prot: WISP3_HUMAN, O95389
    Tissue specificity: Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in
    placenta, ovary, prostate and small intestine. Also expressed in skeletally-derived cells such as synoviocytes
    and articular cartilage chondrocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WISP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WISP3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wisp31 , 5 WNT1 inducible signaling pathway protein 31, 5 82.39(n)1
    78.25(a)1
      10 (20.19 cM)5
    3277431  NM_001127376.11  NP_001120848.11 
     391509715 
    chicken
    (Gallus gallus)
    Aves WISP31 WNT1 inducible signaling pathway protein 3 70.9(n)
    73.07(a)
      770827  XM_001234149.2  XP_001234150.2 
    lizard
    (Anolis carolinensis)
    Reptilia WISP36
    Uncharacterized protein
    65(a)
    1 ↔ 1
    1(192562845-192571150)
    zebrafish
    (Danio rerio)
    Actinopterygii wisp31 WNT1 inducible signaling pathway protein 3 60.59(n)
    60.06(a)
      794092  NM_001166231.1  NP_001159703.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ccn6
    Ccn
    13(a)
    1 → many
    3L(17683115-17741939)


    ENSEMBL Gene Tree for WISP3 (if available)
    TreeFam Gene Tree for WISP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WISP3 gene
    WISP22  NOV2  CTGF2  WISP12  CYR612  
    6 SIMAP similar genes for WISP3 using alignment to 6 protein entries:     WISP3_HUMAN (see all proteins):
    LIBC    wisp3 varinat    WISP1    CTGF    NOV    CYR61

    WISP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/464 SNPs in WISP3 are shown (see all 464)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0162254
    Progressive pseudorheumatoid arthropathy of childhood (PPAC)4--see VAR_0162252 C R mis40--------
    rs170732601,2,4
    C,F,Huntested1112379975(+) AGCCCC/TGTTGC 4 R C mis121Minor allele frequency- T:0.04NA NS EA CSA WA EU 7893
    rs38069651,2
    C,A--109949879(-) CCCCCC/ACCAAC 2 -- us2k12Minor allele frequency- A:0.33WA CSA 3
    rs1427447511,2
    C--109949879(+) GTTGG-/G/GG/G
    GGAGGGG
    /T
    GGGGG
    2 -- us2k10--------
    rs669740021,2
    C--109961603(+) ACACG-/CACACAC 2 -- int10--------
    rs132005761,2
    A--109961616(+) ACACAA/CACACA 2 -- int10--------
    rs1418722041,2
    --112371066(+) ACACCA/GATCAG 2 -- us2k10--------
    rs111533331,2
    C,A,H--112371218(+) atcgaA/Gtcggc 2 -- us2k10--------
    rs1125243441,2
    F--112371326(+) CAGGAG/AGGGGA 2 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs111533341,2
    C,A,H--112371369(+) GGGAGT/GGGGGA 2 -- us2k1 tfbs3 trp31Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for WISP3 (112375275 - 112392171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WISP3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv269575CNV Insertion20981092
    nsv830774CNV Gain17160897


    Human Gene Mutation Database (HGMD): WISP3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WISP3
    DNA2.0 Custom Variant and Variant Library Synthesis for WISP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603400   
    OMIM disorders: 208230  
    UniProtKB/Swiss-Prot: WISP3_HUMAN, O95389
  • Progressive pseudorheumatoid arthropathy of childhood (PPAC) [MIM:208230]: Autosomal recessive disorder
    characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of
    the disease develop typically between three and eight years of age. This progressive disease is a primary
    disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 15 diseases for WISP3:    About MalaCards
    progressive pseudorheumatoid arthropathy of childhood    arthropathy    nephroblastoma    juvenile rheumatoid arthritis
    wilms tumor    chondrosarcoma    breast cancer    arthritis
    rheumatoid arthritis    colorectal cancer    hepatocellular carcinoma    lung cancer
    tuberculosis    endotheliitis    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for WISP3:
    Arthropathy     Juvenile rheumatoid arthritis     Nephroblastoma

    WISP3 for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for WISP3 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progressive pseudorheumatoid dysplasia 98.7 27 17363178 (3), 16029628 (2), 17823661 (2), 17483925 (2) (see all 13)
    inflammatory breast cancer 91.1 15 10499627 (2), 14696649 (1), 18321996 (1), 16457688 (1) (see all 11)
    wilms tumor 57.1 5 15601861 (1), 15611078 (1), 14872491 (1), 15579080 (1)
    arthropathy 55 3 17942216 (1), 17363178 (1)
    aggressiveness 52.8 1 20372786 (1)
    breast cancer 42.5 12 17587813 (3), 20395207 (2), 17406949 (1), 18321996 (1) (see all 7)
    progressive disease 34.7 2 19401829 (1), 16480948 (1)
    tumors 31.6 13 14696649 (2), 15602803 (2), 20131997 (1), 15517620 (1) (see all 8)
    arthritis 16.6 2 15517620 (1), 16480948 (1)
    metastasis 12.5 2 18321996 (1), 20395207 (1)

    Genetic Association Database (GAD): WISP3
    Human Genome Epidemiology (HuGE) Navigator: WISP3 (3 documents)

    Export disorders for WISP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WISP3 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with WISP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PubMed id 9843955)1, 2, 3, 9 Pennica D.... Levine A.J. (1998)
    2. Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PubMed id 20403915)1, 4 Frank B....Brenner H. (2010)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. (PubMed id 10471507)1, 2 Hurvitz J.R.... Warman M.L. (1999)
    7. Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1. (PubMed id 18321996)1, 9 Huang W....Kleer C.G. (2008)
    8. Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis. (PubMed id 15517620)1, 9 Cheon H....Firestein G.S. (2004)
    9. Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF-1 hypothesis of spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA). (PubMed id 17363178)1, 9 Yang Y. and Liao E. (2007)
    10. Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells. (PubMed id 16457688)1, 9 Zhang Y....Kleer C.G. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8838 HGNC: 12771 AceView: WISP3 Ensembl:ENSG00000112761 euGenes: HUgn8838
    ECgene: WISP3 H-InvDB: WISP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WISP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WISP3 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/WISP3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WISP3 gene:
    Search GeneIP for patents involving WISP3

    GeneCards and IP:
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