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WISP3 Gene

protein-coding   GIFtS: 57
GCID: GC06P112375

WNT1 Inducible Signaling Pathway Protein 3

  See WISP3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WNT1 Inducible Signaling Pathway Protein 31 2     PPAC2 5
CCN62 3     PPD2 5
WISP-32 3     LIBC2
CCN Family Member 62 3     WNT1-Inducible-Signaling Pathway Protein 32

External Ids:    HGNC: 127711   Entrez Gene: 88382   Ensembl: ENSG000001127617   OMIM: 6034005   UniProtKB: O953893   

Export aliases for WISP3 gene to outside databases

Previous GC identifers: GC06P112210 GC06P112398 GC06P112420 GC06P112481 GC06P109950


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WISP3 Gene:
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the
connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated
signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by
four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C
module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon
tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation.
Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive
skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage
homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for WISP3 Gene:
WISP3 (WNT1 inducible signaling pathway protein 3) is a protein-coding gene. Diseases associated with WISP3 include progressive pseudorheumatoid arthropathy of childhood, and arthropathy. GO annotations related to this gene include growth factor activity and insulin-like growth factor binding. An important paralog of this gene is WISP2.

UniProtKB/Swiss-Prot: WISP3_HUMAN, O95389
Function: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis

Gene Wiki entry for WISP3 (WNT1-inducible-signaling pathway protein 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WISP3 gene promoter:
         Pbx1a   GCNF   GCNF-1   SEF-1 (1)   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWISP3 promoter sequence
   Search Chromatin IP Primers for WISP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WISP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

WISP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WISP3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P112375:  view genomic region     (about GC identifiers)

Start:
112,375,275 bp from pter      End:
112,392,171 bp from pter
Size:
16,897 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WISP3_HUMAN, O95389 (See protein sequence)
Recommended Name: WNT1-inducible-signaling pathway protein 3 precursor  
Size: 354 amino acids; 39293 Da
Secondary accessions: Q3KR29 Q5H8W4 Q6UXH6
Alternative splicing: 2 isoforms:  O95389-1   O95389-2   

Explore the universe of human proteins at neXtProt for WISP3: NX_O95389

Explore proteomics data for WISP3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn178, Asn308
  • Modification sites at PhosphoSitePlus

  • See WISP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003871.1  NP_937882.1  

    ENSEMBL proteins: 
     ENSP00000357655   ENSP00000473777   ENSP00000395928   ENSP00000357653   ENSP00000357652  
     ENSP00000386467   ENSP00000354734   ENSP00000230529  

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    Cloud-Clone Corp. Proteins for WISP3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR006207 Cys_knot_C
     IPR000867 IGFBP-like
     IPR012395 IGFBP_CNN
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry O95389

    ProtoNet protein and cluster: O95389

    2 Blocks protein domains:
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: WISP3_HUMAN, O95389
    Similarity: Belongs to the CCN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 TSP type-1 domain


    Find genes that share domains with WISP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WISP3_HUMAN, O95389
    Function: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis

         Genatlas biochemistry entry for WISP3:
    WNT1 inducible signaling pathway protein 3,connective tissue growth factor family,CCN family
    (CTGF,IGFBP10,NOU)expressed in adult skeletal muscle,colon,ovary and fetal lung,overexpressed in colon
    tumors,involved in cell growth and differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005520insulin-like growth factor binding IEA--
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with WISP3           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for WISP3:
     Decreased Wnt reporter activit  Decreased homologous recombina  Decreased viability of wild-ty  G0/1 arrest 
     Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Wisp3):
     normal 

    Find genes that share phenotypes with WISP3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WISP3
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    miRTarBase miRNAs that target WISP3:
    hsa-mir-335-5p (MIRT017908), hsa-mir-26b-5p (MIRT029535)

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    Sino Biological Human cDNA Clone for WISP3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WISP3

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    eBioscience FlowRNA Probe Sets ( VA1-14042) for WISP3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WISP3_HUMAN, O95389: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    golgi apparatus1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space NAS9843955

    Find genes that share ontologies with WISP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WISP3
    Interactions:

        GeneGlobe Interaction Network for WISP3

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0007165signal transduction TAS9843955
    GO:0007267cell-cell signaling TAS9843955

    Find genes that share ontologies with WISP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WISP3

    3 Novoseek inferred chemical compound relationships for WISP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanosine 36.5 3 15602803 (2), 14696649 (1)
    cysteine 34.1 1 15579080 (1)
    vegf 4.78 5 14696649 (1), 15602803 (1)



    Find genes that share compounds with WISP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WISP3 gene (3 alternative transcripts): 
    NM_003880.3  NM_198239.1  NM_130396.1  

    Unigene Cluster for WISP3:

    WNT1 inducible signaling pathway protein 3
    Hs.558428  [show with all ESTs]
    Unigene Representative Sequence: NM_198239
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368666(uc003pvo.3) ENST00000604763 ENST00000454589(uc003pvm.3 uc003pvn.3)
    ENST00000483439 ENST00000368664 ENST00000368663 ENST00000409166 ENST00000361714
    ENST00000230529
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    eBioscience FlowRNA Probe Sets ( VA1-14042) for WISP3 

    Additional mRNA sequence: 

    AB075040.1 AF100781.1 AF143679.1 AY358350.1 BC035250.1 BC102031.1 BC105941.1 

    5 DOTS entries:

    DT.412752  DT.91828965  DT.75196414  DT.101981620  DT.40209954 

    Selected AceView cDNA sequences (see all 30):

    AW025138 NM_130396 NM_198239 AY358350 AF100781 AF143679 AW614291 AB075040 
    NM_003880 AY358349 BG290786 CD617635 BM715228 AI457678 CD617637 BC035250 
    BC012028 CN480250 BX281260 BI492770 CD617639 AA592984 AW592899 AW021841 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WISP3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
    SP1:                                -                       -                                       
    SP2:                                                                                                
    SP3:                    -           -                       -                                       
    SP4:                                -                       -                             -         
    SP5:                                      -                 -     -                       -         


    ECgene alternative splicing isoforms for WISP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WISP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGATGGGA
    WISP3 Expression
    About this image

    WISP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WISP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558428

    UniProtKB/Swiss-Prot: WISP3_HUMAN, O95389
    Tissue specificity: Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in
    placenta, ovary, prostate and small intestine. Also expressed in skeletally-derived cells such as synoviocytes
    and articular cartilage chondrocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WISP3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wisp31 , 5 WNT1 inducible signaling pathway protein 31, 5 82.39(n)1
    78.25(a)1
      10 (20.19 cM)5
    3277431  NM_001127376.11  NP_001120848.11 
     391509715 
    chicken
    (Gallus gallus)
    Aves WISP31 WNT1 inducible signaling pathway protein 3 70.9(n)
    73.07(a)
      770827  XM_001234149.3  XP_001234150.2 
    lizard
    (Anolis carolinensis)
    Reptilia WISP36
    WNT1 inducible signaling pathway protein 3
    65(a)
    1 ↔ 1
    1(192562845-192571150)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wisp31 WNT1 inducible signaling pathway protein 3 65.73(n)
    62.07(a)
      100488354  XM_002936933.2  XP_002936979.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wisp31 WNT1 inducible signaling pathway protein 3 60.48(n)
    60.06(a)
      794092  NM_001166231.1  NP_001159703.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ccn6
    Ccn
    14(a)
    1 → many
    3L(17683115-17741939)


    ENSEMBL Gene Tree for WISP3 (if available)
    TreeFam Gene Tree for WISP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WISP3 gene
    WISP22  NOV2  CTGF2  WISP12  CYR612  
    6 SIMAP similar genes for WISP3 using alignment to 6 protein entries:     WISP3_HUMAN (see all proteins):
    LIBC    wisp3 varinat    WISP1    CTGF    NOV    CYR61

    Find genes that share paralogs with WISP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WISP3 (see all 464)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0162254
    Progressive pseudorheumatoid arthropathy of childhood (PPAC)4--see VAR_0162252 C R mis40--------
    rs170732601,2,,4
    C,F,Huntested1112379975(+) AGCCCC/TGTTGC 4 R C mis121Minor allele frequency- T:0.04NA NS EA CSA WA EU 7893
    rs38069651,2
    C,A--109949879(-) CCCCCC/ACCAAC 2 -- us2k12Minor allele frequency- A:0.33WA CSA 3
    rs1427447511,2
    C--109949879(+) GTTGG-/G/GG/G
    GGAGGGG
    /T
    GGGGG
    2 -- us2k10--------
    rs669740021,2
    C--109961603(+) ACACG-/CACACAC 2 -- int10--------
    rs132005761,2
    A--109961616(+) ACACAA/CACACA 2 -- int10--------
    rs1418722041,2
    --112371066(+) ACACCA/GATCAG 2 -- us2k10--------
    rs111533331,2
    C,A,H--112371218(+) atcgaA/Gtcggc 2 -- us2k10--------
    rs1125243441,2
    F--112371326(+) CAGGAG/AGGGGA 2 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs111533341,2
    C,A,H--112371369(+) GGGAGT/GGGGGA 2 -- us2k1 tfbs3 trp31Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for WISP3 (112375275 - 112392171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WISP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269575CNV Insertion20981092
    nsv830774CNV Gain17160897

    Human Gene Mutation Database (HGMD): WISP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WISP3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603400   
    OMIM disorders: 208230  
    UniProtKB/Swiss-Prot: WISP3_HUMAN, O95389
  • Progressive pseudorheumatoid arthropathy of childhood (PPAC) [MIM:208230]: Autosomal recessive disorder
    characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of
    the disease develop typically between three and eight years of age. This progressive disease is a primary
    disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for WISP3:    
    About MalaCards
    progressive pseudorheumatoid arthropathy of childhood    arthropathy    nephroblastoma    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for WISP3:
    Arthropathy     Juvenile rheumatoid arthritis     Nephroblastoma

    Find genes that share disorders with WISP3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for WISP3 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progressive pseudorheumatoid dysplasia 98.7 27 17363178 (3), 16029628 (2), 17823661 (2), 17483925 (2) (see all 13)
    inflammatory breast cancer 91.1 15 10499627 (2), 14696649 (1), 18321996 (1), 16457688 (1) (see all 11)
    wilms tumor 57.1 5 15601861 (1), 15611078 (1), 14872491 (1), 15579080 (1)
    arthropathy 55 3 17942216 (1), 17363178 (1)
    aggressiveness 52.8 1 20372786 (1)
    breast cancer 42.5 12 17587813 (3), 20395207 (2), 17406949 (1), 18321996 (1) (see all 7)
    progressive disease 34.7 2 19401829 (1), 16480948 (1)
    tumors 31.6 13 14696649 (2), 15602803 (2), 20131997 (1), 15517620 (1) (see all 8)
    arthritis 16.6 2 15517620 (1), 16480948 (1)
    metastasis 12.5 2 18321996 (1), 20395207 (1)

    Genetic Association Database (GAD): WISP3
    Human Genome Epidemiology (HuGE) Navigator: WISP3 (3 documents)

    Export disorders for WISP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WISP3 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with WISP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PubMed id 9843955)1, 2, 3, 9 Pennica D.... Levine A.J. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PubMed id 20403915)1, 4 Frank B....Brenner H. (Carcinogenesis 2010)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. (PubMed id 10471507)1, 2 Hurvitz J.R.... Warman M.L. (Nat. Genet. 1999)
    7. Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1. (PubMed id 18321996)1, 9 Huang W....Kleer C.G. (Am. J. Pathol. 2008)
    8. Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis. (PubMed id 15517620)1, 9 Cheon H....Firestein G.S. (J. Rheumatol. 2004)
    9. Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF-1 hypothesis of spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA). (PubMed id 17363178)1, 9 Yang Y. and Liao E. (Med. Hypotheses 2007)
    10. Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells. (PubMed id 16457688)1, 9 Zhang Y....Kleer C.G. (Breast Cancer Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8838 HGNC: 12771 AceView: WISP3 Ensembl:ENSG00000112761 euGenes: HUgn8838
    ECgene: WISP3 H-InvDB: WISP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WISP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WISP3 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=WISP3[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WISP3 gene:
    Search GeneIP for patents involving WISP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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