Aliases for WISP3 Gene
External Ids for WISP3 Gene
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for WISP3 Gene
WISP3 (WNT1 Inducible Signaling Pathway Protein 3) is a Protein Coding gene. Diseases associated with WISP3 include arthropathy, progressive pseudorheumatoid, of childhood and spondyloepiphyseal dysplasia tarda. GO annotations related to this gene include growth factor activity and insulin-like growth factor binding. An important paralog of this gene is NOV.
UniProtKB/Swiss-Prot for WISP3 Gene
Appears to be required for normal postnatal skeletal growth and cartilage homeostasis