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Aliases for WISP3 Gene

Aliases for WISP3 Gene

  • WNT1 Inducible Signaling Pathway Protein 3 2 3
  • CCN Family Member 6 3 4
  • WISP-3 3 4
  • PPAC 3 6
  • CCN6 3 4
  • PPD 3 6
  • WNT1-Inducible-Signaling Pathway Protein 3 3
  • LIBC 3

External Ids for WISP3 Gene

Previous GeneCards Identifiers for WISP3 Gene

  • GC06P112210
  • GC06P112398
  • GC06P112420
  • GC06P112481
  • GC06P112375
  • GC06P109950

Summaries for WISP3 Gene

Entrez Gene Summary for WISP3 Gene

  • This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WISP3 Gene

WISP3 (WNT1 Inducible Signaling Pathway Protein 3) is a Protein Coding gene. Diseases associated with WISP3 include arthropathy, progressive pseudorheumatoid, of childhood and spondyloepiphyseal dysplasia tarda. GO annotations related to this gene include growth factor activity and insulin-like growth factor binding. An important paralog of this gene is NOV.

UniProtKB/Swiss-Prot for WISP3 Gene

  • Appears to be required for normal postnatal skeletal growth and cartilage homeostasis

Gene Wiki entry for WISP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WISP3 Gene

Genomics for WISP3 Gene

Regulatory Elements for WISP3 Gene

Genomic Location for WISP3 Gene

112,025,707 bp from pter
112,070,969 bp from pter
45,263 bases
Plus strand

Genomic View for WISP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WISP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WISP3 Gene

Proteins for WISP3 Gene

  • Protein details for WISP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WNT1-inducible-signaling pathway protein 3
    Protein Accession:
    Secondary Accessions:
    • Q3KR29
    • Q5H8W4
    • Q6UXH6

    Protein attributes for WISP3 Gene

    354 amino acids
    Molecular mass:
    39293 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WISP3 Gene


neXtProt entry for WISP3 Gene

Proteomics data for WISP3 Gene at MOPED

Post-translational modifications for WISP3 Gene

  • Glycosylation at Asn178 and Asn308
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WISP3 Gene

Domains for WISP3 Gene

Suggested Antigen Peptide Sequences for WISP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • O95389
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 TSP type-1 domain.
  • Belongs to the CCN family.
genes like me logo Genes that share domains with WISP3: view

No data available for Gene Families for WISP3 Gene

Function for WISP3 Gene

Molecular function for WISP3 Gene

GENATLAS Biochemistry: WNT1 inducible signaling pathway protein 3,connective tissue growth factor family,CCN family (CTGF,IGFBP10,NOU)expressed in adult skeletal muscle,colon,ovary and fetal lung,overexpressed in colon tumors,involved in cell growth and differentiation
UniProtKB/Swiss-Prot Function: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis

Gene Ontology (GO) - Molecular Function for WISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IBA --
GO:0005520 insulin-like growth factor binding IEA --
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IBA --
genes like me logo Genes that share ontologies with WISP3: view
genes like me logo Genes that share phenotypes with WISP3: view

Animal Model Products

CRISPR Products

miRNA for WISP3 Gene

miRTarBase miRNAs that target WISP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WISP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WISP3 Gene

Localization for WISP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WISP3 Gene


Subcellular locations from

Jensen Localization Image for WISP3 Gene COMPARTMENTS Subcellular localization image for WISP3 gene
Compartment Confidence
extracellular 5
plasma membrane 2
golgi apparatus 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space NAS 9843955
genes like me logo Genes that share ontologies with WISP3: view

Pathways for WISP3 Gene

SuperPathways for WISP3 Gene

No Data Available

Interacting Proteins for WISP3 Gene

Gene Ontology (GO) - Biological Process for WISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007155 cell adhesion IBA --
GO:0007165 signal transduction TAS 9843955
GO:0007267 cell-cell signaling TAS 9843955
GO:0060548 negative regulation of cell death IBA --
genes like me logo Genes that share ontologies with WISP3: view

No data available for Pathways by source for WISP3 Gene

Compounds for WISP3 Gene

(3) Novoseek inferred chemical compound relationships for WISP3 Gene

Compound -log(P) Hits PubMed IDs
guanosine 36.5 3
cysteine 34.1 1
vegf 4.78 2
genes like me logo Genes that share compounds with WISP3: view

Transcripts for WISP3 Gene

Unigene Clusters for WISP3 Gene

WNT1 inducible signaling pathway protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WISP3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for WISP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WISP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - - - - -

Relevant External Links for WISP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WISP3 Gene

mRNA expression in normal human tissues for WISP3 Gene

mRNA differential expression in normal tissues according to GTEx for WISP3 Gene

This gene is overexpressed in Testis (8.5), Skin - Sun Exposed (Lower leg) (8.2), and Skin - Not Sun Exposed (Suprapubic) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for WISP3 Gene

SOURCE GeneReport for Unigene cluster for WISP3 Gene Hs.558428

mRNA Expression by UniProt/SwissProt for WISP3 Gene

Tissue specificity: Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in placenta, ovary, prostate and small intestine. Also expressed in skeletally-derived cells such as synoviocytes and articular cartilage chondrocytes
genes like me logo Genes that share expressions with WISP3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for WISP3 Gene

Orthologs for WISP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for WISP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WISP3 35
  • 99.1 (n)
  • 99.19 (a)
WISP3 36
  • 99 (a)
(Bos Taurus)
Mammalia WISP3 35
  • 87.48 (n)
  • 83.62 (a)
WISP3 36
  • 84 (a)
(Canis familiaris)
Mammalia WISP3 36
  • 82 (a)
(Mus musculus)
Mammalia Wisp3 35
  • 82.39 (n)
  • 78.25 (a)
Wisp3 16
Wisp3 36
  • 78 (a)
(Monodelphis domestica)
Mammalia WISP3 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia WISP3 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Wisp3 35
  • 80.79 (n)
  • 76.55 (a)
(Gallus gallus)
Aves WISP3 35
  • 70.9 (n)
  • 73.07 (a)
WISP3 36
  • 66 (a)
(Anolis carolinensis)
Reptilia WISP3 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wisp3 35
  • 65.73 (n)
  • 62.07 (a)
(Danio rerio)
Actinopterygii wisp3 35
  • 60.48 (n)
  • 60.06 (a)
wisp3 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ccn 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for WISP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WISP3 Gene

Gene Tree for WISP3 (if available)
Gene Tree for WISP3 (if available)

Paralogs for WISP3 Gene

Paralogs for WISP3 Gene

Selected SIMAP similar genes for WISP3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with WISP3: view

Variants for WISP3 Gene

Sequence variations from dbSNP and Humsavar for WISP3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs730436 -- 112,064,581(-) TAAAG(G/T)GAGGC intron-variant
rs744005 -- 112,063,922(+) gtcac(A/G)tagaa intron-variant
rs925755 -- 112,029,126(+) GAGAA(A/C)GTGCA intron-variant
rs990601 -- 112,042,557(-) GGAGG(C/T)CAATC intron-variant
rs1022313 -- 112,053,741(-) CTCAC(C/T)TTTAT upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WISP3 Gene

Variant ID Type Subtype PubMed ID
nsv830774 CNV Gain 17160897
esv269575 CNV Insertion 20981092

Relevant External Links for WISP3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WISP3 Gene

Disorders for WISP3 Gene

(1) OMIM Diseases for WISP3 Gene (603400)


  • Progressive pseudorheumatoid arthropathy of childhood (PPAC) [MIM:208230]: Autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. {ECO:0000269 PubMed:10471507}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for WISP3 Gene

(11) Novoseek inferred disease relationships for WISP3 Gene

Disease -log(P) Hits PubMed IDs
progressive pseudorheumatoid dysplasia 98.7 20
inflammatory breast cancer 91.1 12
wilms tumor 57.1 4
arthropathy 55 2
aggressiveness 52.8 1

Relevant External Links for WISP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with WISP3: view

Publications for WISP3 Gene

  1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PMID: 9843955) Pennica D. … Levine A.J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1. (PMID: 18321996) Huang W. … Kleer C.G. (Am. J. Pathol. 2008) 3 23
  3. Identification of novel mutations in WISP3 gene in two unrelated Chinese families with progressive pseudorheumatoid dysplasia. (PMID: 19064006) Yue H. … He J.W. (Bone 2009) 3 23
  4. Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications. (PMID: 20372786) Davies S.R. … Jiang W.G. (Int. J. Oncol. 2010) 3 23
  5. Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells. (PMID: 20395207) Huang W. … Kleer C.G. (Cancer Res. 2010) 3 23

Products for WISP3 Gene

  • antibodies-online proteins for WISP3
  • antibodies-online antibodies for WISP3
  • antibodies-online kits for WISP3

Sources for WISP3 Gene

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