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WISP2 Gene

protein-coding   GIFtS: 55
GCID: GC20P043343

WNT1 Inducible Signaling Pathway Protein 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WNT1 Inducible Signaling Pathway Protein 21 2     WISP-22 3
Connective Tissue Growth Factor-Like Protein2 3     CCN Family Member 52 3
Connective Tissue Growth Factor-Related Protein 582 3     Wnt-1 Signaling Pathway Protein 22
CCN52 3     WNT1-Inducible-Signaling Pathway Protein 22
CT582 3     CTGFL3
CTGF-L2 3     

External Ids:    HGNC: 127701   Entrez Gene: 88392   Ensembl: ENSG000000642057   OMIM: 6033995   UniProtKB: O760763   

Export aliases for WISP2 gene to outside databases

Previous GC identifers: GC20P043072 GC20P043981 GC20P044029 GC20P042777 GC20P040085


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WISP2 Gene:
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the
connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated
signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by
four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C
module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT
domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the
amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant
transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in
colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone
turnover. (provided by RefSeq, Jul 2008)

GeneCards Summary for WISP2 Gene:
WISP2 (WNT1 inducible signaling pathway protein 2) is a protein-coding gene. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is NOV.

UniProtKB/Swiss-Prot: WISP2_HUMAN, O76076
Function: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and
inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production

Gene Wiki entry for WISP2 (WNT1-inducible-signaling pathway protein 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WISP2 gene promoter:
         AhR   AML1a   AP-2gamma   Arnt   E47   PPAR-gamma1   SEF-1 (1)   ARP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): WISP2 promoter sequence
   Search Chromatin IP Primers for WISP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WISP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

WISP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WISP2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P043343:  view genomic region     (about GC identifiers)

Start:
43,343,485 bp from pter      End:
43,357,150 bp from pter
Size:
13,666 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WISP2_HUMAN, O76076 (See protein sequence)
Recommended Name: WNT1-inducible-signaling pathway protein 2 precursor  
Size: 250 amino acids; 26825 Da
Secondary accessions: B2R9N4 E1P612

Explore the universe of human proteins at neXtProt for WISP2: NX_O76076

Explore proteomics data for WISP2 at MOPED


See WISP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003872.1  
ENSEMBL proteins: 
 ENSP00000361959   ENSP00000361956   ENSP00000190983  

WISP2 Human Recombinant Protein Products:

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antibodies-online proteins for WISP2 (14 products) 

 
antibodies-online peptides for WISP2

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antibodies-online antibodies for WISP2 (58 products) 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:
 IPR000884 Thrombospondin_1_rpt
 IPR000867 IGFBP-like
 IPR017891 Insulin_GF-bd_Cys-rich_CS
 IPR009030 Growth_fac_rcpt_N_dom
 IPR001007 VWF_C

Graphical View of Domain Structure for InterPro Entry O76076

ProtoNet protein and cluster: O76076

2 Blocks protein domains:
IPB000884 Thrombospondin
IPB001007 von Willebrand factor


UniProtKB/Swiss-Prot: WISP2_HUMAN, O76076
Similarity: Belongs to the CCN family
Similarity: Contains 1 IGFBP N-terminal domain
Similarity: Contains 1 TSP type-1 domain
Similarity: Contains 1 VWFC domain


Find genes that share domains with WISP2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: WISP2_HUMAN, O76076
Function: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and
inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production

     Genatlas biochemistry entry for WISP2:
WNT1 inducible signaling pathway protein 2,connective tissue growth factor family,expressed in adult
kidney,testis,fetal lung,ovary,heart osteoblasts and fibroblasts,with a reduced expression in colon
tumors,involved in modulating bone turnover

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0005520insulin-like growth factor binding IEA--
     
Find genes that share ontologies with WISP2           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Wisp2 (no phenotypes)

Find genes that share phenotypes with WISP2           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for WISP2

miRNA
Products:
    
miRTarBase miRNAs that target WISP2:
hsa-mir-449a (MIRT006502), hsa-mir-124-3p (MIRT022148)

Block miRNA regulation of human, mouse, rat WISP2 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate WISP2:
hsa-miR-1184 hsa-miR-3065-3p
SwitchGear 3'UTR luciferase reporter plasmidWISP2 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for WISP2
Predesigned siRNA for gene silencing in human, mouse, rat WISP2

Gene Editing
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WISP2

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WISP2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
WISP2_HUMAN, O76076: Secreted (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
plasma membrane2
cytosol1
lysosome1
mitochondrion1
nucleus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IDA10358067
GO:0005886plasma membrane IEA--

Find genes that share ontologies with WISP2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Arrays including WISP2: 
          Estrogen Receptor Signaling in human mouse rat
          WNT Signaling Targets in human mouse rat

Interactions:

    GeneGlobe Interaction Network for WISP2

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

Selected Interacting proteins for WISP2 (O760763 ENSP000001909834) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
IGF1P050193, ENSP000003026654I2D: score=1 STRING: ENSP00000302665
IGF1RP080693I2D: score=1 
HDAC1ENSP000003626494STRING: ENSP00000362649
HDAC3ENSP000003029674STRING: ENSP00000302967
--C9JAF23I2D: score=1 
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001558regulation of cell growth IEA--
GO:0007155cell adhesion IEA--
GO:0007165signal transduction TAS9843955
GO:0007267cell-cell signaling TAS9843955

Find genes that share ontologies with WISP2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for WISP2

5 Novoseek inferred chemical compound relationships for WISP2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen 36 13 12659671 (4), 10944450 (2), 17308090 (1), 15743834 (1) (see all 5)
cycloheximide 26.9 3 10944450 (1), 12951045 (1)
heparin 9.1 2 10358067 (1), 11584015 (1)
cysteine 8.4 1 15579080 (1)
progesterone 8.21 4 12659671 (3), 15743834 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for WISP2 gene: 
NM_003881.2  

Unigene Cluster for WISP2:

WNT1 inducible signaling pathway protein 2
Hs.592145  [show with all ESTs]
Unigene Representative Sequence: AK074695
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000372868 ENST00000372865(uc002xmq.3) ENST00000497421(uc002xmo.1)
ENST00000190983(uc002xmp.3) ENST00000465000 ENST00000471629
miRNA
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Block miRNA regulation of human, mouse, rat WISP2 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate WISP2:
hsa-miR-1184 hsa-miR-3065-3p
SwitchGear 3'UTR luciferase reporter plasmidWISP2 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for WISP2
Predesigned siRNA for gene silencing in human, mouse, rat WISP2
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OriGene clones in human, mouse for WISP2 (see all 6)
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GenScript: all cDNA clones in your preferred vector: WISP2 (NM_003881)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for WISP2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WISP2
Primer
Products:
    
OriGene qPCR primer pairs and template standards for WISP2
OriGene qSTAR qPCR primer pairs in human, mouse for WISP2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WISP2
  QuantiTect SYBR Green Assays in human, mouse, rat WISP2
  QuantiFast Probe-based Assays in human, mouse, rat WISP2

Additional mRNA sequence: 

AF074604.1 AF083500.1 AK074695.1 AK313853.1 AY358915.1 BC017782.2 BC058074.1 BC064379.1 

7 DOTS entries:

DT.101978124  DT.100027401  DT.100788404  DT.120810299  DT.40316146  DT.120810352  DT.40246004 

Selected AceView cDNA sequences (see all 91):

AY358915 BM751866 AF083500 BU539788 AI472684 BF516162 BC064379 NM_003881 
BQ002854 BX327577 CD517077 CR603485 BQ002414 AI400318 AL555144 BI457141 
BU943917 BM043988 BU857027 CD515450 BX280886 BQ279131 BM543799 BM046275 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for WISP2 (see all 6)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1:        -                       -     -     -                                 
SP2:                                -     -     -                                 
SP3:                                      -     -     -     -                     
SP4:                                      -     -                                 
SP5:                                                                              


ECgene alternative splicing isoforms for WISP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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WISP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CACACGGGCG
WISP2 Expression
About this image


WISP2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Granulosa Cells Primary Follicle
 
 Adipose (Muscoskeletal System)    fully expand to see all 2 entries
         Visceral White Adipocytes Visceral White Adipose
 
 Heart (Cardiovascular System)
         Atrioventricular Node Cells Atrioventricular Node
 
 Testis (Reproductive System)
         Mature Sertoli Cells Seminiferous Tubules
 
 Breast (Uncategorized)
WISP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

WISP2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.592145

UniProtKB/Swiss-Prot: WISP2_HUMAN, O76076
Tissue specificity: Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart

    Pathway & Disease-focused RT2 Profiler PCR Arrays including WISP2: 
          Estrogen Receptor Signaling in human mouse rat
          WNT Signaling Targets in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for WISP2
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QuantiFast Probe-based Assays in human, mouse, rat WISP2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WISP2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for WISP2 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Wisp21 , 5 WNT1 inducible signaling pathway protein 21, 5 80(n)1
73.2(a)1
  2 (84.49 cM)5
224031  NM_016873.21  NP_058569.21 
 1638208615 
chicken
(Gallus gallus)
Aves WISP21 WNT1 inducible signaling pathway protein 2 68.21(n)
64.95(a)
  419192  XM_004947031.1  XP_004947088.1 
lizard
(Anolis carolinensis)
Reptilia WISP26
WNT1 inducible signaling pathway protein 2
53(a)
1 ↔ 1
4(143908658-143916846)
zebrafish
(Danio rerio)
Actinopterygii wisp26
WNT1 inducible signaling pathway protein 2
32(a)
1 ↔ 1
23(26281025-26291197) ENSDARG00000077882


ENSEMBL Gene Tree for WISP2 (if available)
TreeFam Gene Tree for WISP2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for WISP2 gene
NOV2  CTGF2  WISP32  WISP12  CYR612  
3 SIMAP similar genes for WISP2 using alignment to 2 protein entries:     WISP2_HUMAN (see all proteins):
NOV    CTGF    WISP1

Find genes that share paralogs with WISP2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for WISP2 (see all 384)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs61038391,2
C,F,H--43341905(+) cctccT/Cgggtt 1 -- us2k16Minor allele frequency- C:0.43NA CSA 14
rs360299291,2
C,F--43341963(+) GTGCAC/TCCACC 1 -- us2k17Minor allele frequency- T:0.18NA WA EA 366
rs1439114901,2
C--43341970(+) CACCAC/TGTCCG 1 -- us2k10--------
rs759181371,2
C--43342028(+) TGGCCA/CGGCTG 1 -- us2k10--------
rs1924955761,2
--43342041(+) CTTGAA/GCTCCT 1 -- us2k10--------
rs60317581,2
C,F,A,H--43342049(+) cctgaC/Tctcag 1 -- us2k114Minor allele frequency- T:0.47NA WA CSA EA 377
rs1421471621,2
--43342150(+) ATGAAA/CGCAGA 1 -- us2k10--------
rs793009271,2
C,F--43342203(+) TTTACG/AAAACT 1 -- us2k13Minor allele frequency- A:0.04WA CSA 122
rs1474134191,2
--43342291(+) GGTAAA/GTGCAA 1 -- us2k10--------
rs1834812591,2
C--43342480(+) TTAAAA/GGATCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for WISP2 (43343485 - 43357150 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for WISP2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv179790CNV Loss16902084
nsv458985CNV Gain19166990
esv1001878CNV Gain20482838

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing WISP2
DNA2.0 Custom Variant and Variant Library Synthesis for WISP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603399    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for WISP2:
Nephroblastoma

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4 Novoseek inferred disease relationships for WISP2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
wilms tumor 63.2 4 15611078 (1), 15579080 (1), 17170219 (1)
breast cancer 37.6 11 18794149 (4), 10944450 (1), 17406949 (1), 18559502 (1) (see all 6)
tumors 26.3 22 12659671 (3), 18794149 (2), 17406949 (2), 18559502 (2) (see all 10)
cancer 9.96 4 18794149 (2), 18559502 (1), 20372786 (1)

Genetic Association Database (GAD): WISP2
Human Genome Epidemiology (HuGE) Navigator: WISP2 (2 documents)

Export disorders for WISP2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for WISP2 gene, integrated from 10 sources (see all 49):
(articles sorted by number of sources associating them with WISP2)
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  1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PubMed id 9843955)1, 2, 3, 9 Pennica D.... Levine A.J. (Proc. Natl. Acad. Sci. U.S.A. 1998)
  2. Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. (PubMed id 10358067)1, 2, 9 Kumar S.... Lee J.C. (J. Biol. Chem. 1999)
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
  8. WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation. (PubMed id 12659671)1, 9 Banerjee S....Banerjee S.K. (Neoplasia 2003)
  9. CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells. (PubMed id 18794149)1, 9 Banerjee S....Banerjee S.K. (Cancer Res. 2008)
  10. Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2. (PubMed id 18559502)1, 9 Dhar G....Banerjee S.K. (Cancer Res. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8839 HGNC: 12770 AceView: WISP2 Ensembl:ENSG00000064205 euGenes: HUgn8839
ECgene: WISP2 H-InvDB: WISP2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for WISP2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WISP2 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for WISP2 gene:
Search GeneIP for patents involving WISP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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