Aliases for WISP2 Gene
External Ids for WISP2 Gene
Previous GeneCards Identifiers for WISP2 Gene
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]
GeneCards Summary for WISP2 Gene
WISP2 (WNT1 Inducible Signaling Pathway Protein 2) is a Protein Coding gene. Diseases associated with WISP2 include Breast Adenocarcinoma and Wilms Tumor Susceptibility-5. GO annotations related to this gene include heparin binding and insulin-like growth factor binding. An important paralog of this gene is NOV.
UniProtKB/Swiss-Prot for WISP2 Gene
May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.