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Aliases for WISP2 Gene

Aliases for WISP2 Gene

  • WNT1 Inducible Signaling Pathway Protein 2 2 3
  • Connective Tissue Growth Factor-Related Protein 58 3 4
  • Connective Tissue Growth Factor-Like Protein 3 4
  • CCN Family Member 5 3 4
  • CTGF-L 3 4
  • WISP-2 3 4
  • CT58 3 4
  • CCN5 3 4
  • WNT1-Inducible-Signaling Pathway Protein 2 3
  • Wnt-1 Signaling Pathway Protein 2 3
  • CTGFL 4

External Ids for WISP2 Gene

Summaries for WISP2 Gene

Entrez Gene Summary for WISP2 Gene

  • This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

GeneCards Summary for WISP2 Gene

WISP2 (WNT1 Inducible Signaling Pathway Protein 2) is a Protein Coding gene. Diseases associated with WISP2 include breast adenocarcinoma. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is NOV.

UniProtKB/Swiss-Prot for WISP2 Gene

  • May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production

Gene Wiki entry for WISP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WISP2 Gene

Genomics for WISP2 Gene

Genomic Location for WISP2 Gene

Start:
44,714,844 bp from pter
End:
44,728,509 bp from pter
Size:
13,666 bases
Orientation:
Plus strand

Genomic View for WISP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WISP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WISP2 Gene

Regulatory Elements for WISP2 Gene

Proteins for WISP2 Gene

  • Protein details for WISP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76076-WISP2_HUMAN
    Recommended name:
    WNT1-inducible-signaling pathway protein 2
    Protein Accession:
    O76076
    Secondary Accessions:
    • B2R9N4
    • E1P612
    • Q6PEG3

    Protein attributes for WISP2 Gene

    Size:
    250 amino acids
    Molecular mass:
    26825 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WISP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WISP2 Gene

Proteomics data for WISP2 Gene at MOPED

Post-translational modifications for WISP2 Gene

No Post-translational modifications

Other Protein References for WISP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WISP2 Gene

Domains for WISP2 Gene

UniProtKB/Swiss-Prot:

WISP2_HUMAN
Domain:
  • Contains 1 IGFBP N-terminal domain.:
    • O76076
  • Contains 1 TSP type-1 domain.:
    • O76076
  • Contains 1 VWFC domain.:
    • O76076
Family:
  • Belongs to the CCN family.:
    • O76076
genes like me logo Genes that share domains with WISP2: view

No data available for Gene Families for WISP2 Gene

Function for WISP2 Gene

Molecular function for WISP2 Gene

GENATLAS Biochemistry: WNT1 inducible signaling pathway protein 2,connective tissue growth factor family,expressed in adult kidney,testis,fetal lung,ovary,heart osteoblasts and fibroblasts,with a reduced expression in colon tumors,involved in modulating bone turnover
UniProtKB/Swiss-Prot Function: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production

Gene Ontology (GO) - Molecular Function for WISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IBA --
GO:0005515 protein binding --
GO:0005520 insulin-like growth factor binding IEA --
GO:0008201 heparin binding IBA --
genes like me logo Genes that share ontologies with WISP2: view

miRNA for WISP2 Gene

miRTarBase miRNAs that target WISP2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WISP2 Gene

Localization for WISP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WISP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WISP2 Gene COMPARTMENTS Subcellular localization image for WISP2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space IDA 10358067
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with WISP2: view

Pathways for WISP2 Gene

SuperPathways for WISP2 Gene

No Data Available

Interacting Proteins for WISP2 Gene

Gene Ontology (GO) - Biological Process for WISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007155 cell adhesion IBA --
GO:0007165 signal transduction TAS 9843955
GO:0007267 cell-cell signaling TAS 9843955
GO:0060548 negative regulation of cell death IBA --
genes like me logo Genes that share ontologies with WISP2: view

No data available for Pathways by source for WISP2 Gene

Compounds for WISP2 Gene

(5) Novoseek inferred chemical compound relationships for WISP2 Gene

Compound -log(P) Hits PubMed IDs
estrogen 36 9
cycloheximide 26.9 2
heparin 9.1 2
cysteine 8.4 1
progesterone 8.21 4
genes like me logo Genes that share compounds with WISP2: view

Transcripts for WISP2 Gene

Unigene Clusters for WISP2 Gene

WNT1 inducible signaling pathway protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WISP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:
SP6:

Relevant External Links for WISP2 Gene

GeneLoc Exon Structure for
WISP2
ECgene alternative splicing isoforms for
WISP2

Expression for WISP2 Gene

mRNA expression in normal human tissues for WISP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WISP2 Gene

This gene is overexpressed in Artery - Tibial (8.8), Artery - Aorta (5.4), Artery - Coronary (5.2), and Adipose - Subcutaneous (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for WISP2 Gene

SOURCE GeneReport for Unigene cluster for WISP2 Gene Hs.592145

mRNA Expression by UniProt/SwissProt for WISP2 Gene

O76076-WISP2_HUMAN
Tissue specificity: Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart
genes like me logo Genes that share expressions with WISP2: view

Orthologs for WISP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WISP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WISP2 36
  • 99.47 (n)
  • 99.6 (a)
WISP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WISP2 36
  • 87.07 (n)
  • 85.6 (a)
WISP2 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WISP2 36
  • 88.13 (n)
  • 85.6 (a)
WISP2 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wisp2 36
  • 80 (n)
  • 73.2 (a)
Wisp2 16
Wisp2 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WISP2 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WISP2 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wisp2 36
  • 78.4 (n)
  • 70.8 (a)
chicken
(Gallus gallus)
Aves WISP2 36
  • 68.21 (n)
  • 64.95 (a)
WISP2 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WISP2 37
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wisp2 37
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 21 (a)
ManyToMany
-- 37
  • 25 (a)
ManyToMany
Species with no ortholog for WISP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WISP2 Gene

ENSEMBL:
Gene Tree for WISP2 (if available)
TreeFam:
Gene Tree for WISP2 (if available)

Paralogs for WISP2 Gene

Paralogs for WISP2 Gene

Selected SIMAP similar genes for WISP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WISP2: view

Variants for WISP2 Gene

Sequence variations from dbSNP and Humsavar for WISP2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs753740 -- 44,726,014(-) GATGG(C/T)GGGGC intron-variant
rs912923 -- 44,717,177(+) ACACG(C/G)TTTGA intron-variant
rs942906 -- 44,726,749(+) AGCAC(C/T)ACTCC intron-variant
rs1061098 -- 44,727,515(+) AGTCC(C/T)CTTTC utr-variant-3-prime
rs1536229 -- 44,727,877(+) GGGGC(A/G)GAGTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for WISP2 Gene

Variant ID Type Subtype PubMed ID
nsv458985 CNV Gain 19166990
nsv179790 CNV Loss 16902084
esv1001878 CNV Gain 20482838

Relevant External Links for WISP2 Gene

HapMap Linkage Disequilibrium report
WISP2

Disorders for WISP2 Gene

(1) MalaCards Diseases for WISP2 Gene

Search for WISP2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for WISP2 Gene

(4) Novoseek inferred disease relationships for WISP2 Gene

Disease -log(P) Hits PubMed IDs
wilms tumor 63.2 3
breast cancer 37.6 9
tumors 26.3 18
cancer 9.96 4

Relevant External Links for WISP2

Genetic Association Database (GAD)
WISP2
Human Genome Epidemiology (HuGE) Navigator
WISP2
genes like me logo Genes that share disorders with WISP2: view

No data available for UniProtKB/Swiss-Prot for WISP2 Gene

Publications for WISP2 Gene

  1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PMID: 9843955) Pennica D. … Levine A.J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. (PMID: 10358067) Kumar S. … Lee J.C. (J. Biol. Chem. 1999) 3 4 23
  3. Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines. (PMID: 11855747) Saxena N. … Banerjee S.K. (Mol. Cell. Biochem. 2001) 3 23
  4. Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks. (PMID: 15798095) Banerjee S. … Banerjee S.K. (Mol. Cancer Res. 2005) 3 23
  5. WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation. (PMID: 12659671) Banerjee S. … Banerjee S.K. (Neoplasia 2003) 3 23

Products for WISP2 Gene

Sources for WISP2 Gene

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