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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WISP2 Gene

protein-coding   GIFtS: 55
GCID: GC20P043343

WNT1 inducible signaling pathway protein 2
 Explore 13 diseases affiliated with
WISP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WISP2    

Aliases
for WISP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
WNT1 Inducible Signaling Pathway Protein 21 2     WISP-22 3
CCN51 2 3     CCN Family Member 52 3
CT581 2 3     Wnt-1 Signaling Pathway Protein 22
CTGF-L1 2 3     WNT1-Inducible-Signaling Pathway Protein 22
Connective Tissue Growth Factor-Like Protein2 3     CTGFL3
Connective Tissue Growth Factor-Related Protein 582 3     

External Ids:    HGNC: 127701   Entrez Gene: 88392   Ensembl: ENSG000000642057   OMIM: 6033995   UniProtKB: O760763   

Export aliases for WISP2 gene to outside databases

Previous GC identifers: GC20P043072 GC20P043981 GC20P044029 GC20P042777 GC20P040085


Summaries
for WISP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WISP2:
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the
connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling
proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved
cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin
domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in
dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be
downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors
is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone
tissue, and may play an important role in modulating bone turnover. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WISP2_HUMAN, O76076
Function: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and
inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production

Gene Wiki entry for WISP2 (WNT1-inducible-signaling pathway protein 2)


Genomic Views
for WISP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WISP2 gene promoter:
         AhR   AML1a   AP-2gamma   Arnt   E47   PPAR-gamma1   SEF-1 (1)   ARP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): WISP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for WISP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WISP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

WISP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WISP2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P043343:  view genomic region     (about GC identifiers)

Start:
 43,343,485 bp from pter      End:
 43,357,150 bp from pter
Size:
 13,666 bases      Orientation:
 plus strand

Proteins
for WISP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WISP2_HUMAN, O76076 (See protein sequence)
Recommended Name: WNT1-inducible-signaling pathway protein 2 precursor  
Size: 250 amino acids; 26825 Da
Subcellular location: Secreted (Probable)
Secondary accessions: B2R9N4 E1P612

Explore the universe of human proteins at neXtProt for WISP2: NX_O76076

WISP2 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_003872.1  
ENSEMBL proteins: 
 ENSP00000361959   ENSP00000361956   ENSP00000190983  

Human Recombinant Protein Products: 
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Novus Biologicals WISP2 Lysates
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Uscn Proteins for WISP2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IDA10358067
GO:0005625soluble fraction ----
GO:0005737cytoplasm ----
GO:0005886plasma membrane IEA--


WISP2 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for WISP2

Protein Domains /
Families
for WISP2 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
WISP2 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR000884 Thrombospondin_1_rpt
 IPR017891 Insulin_GF-bd_Cys-rich_CS
 IPR001007 VWF_C
 IPR000867 IGFBP-like

Graphical View of Domain Structure for InterPro Entry O76076

ProtoNet protein and cluster: O76076

2 Blocks protein families:
IPB000884 Thrombospondin
IPB001007 von Willebrand factor


UniProtKB/Swiss-Prot: WISP2_HUMAN, O76076
Similarity: Belongs to the CCN family
Similarity: Contains 1 IGFBP N-terminal domain
Similarity: Contains 1 TSP type-1 domain
Similarity: Contains 1 VWFC domain


Function
for WISP2 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: WISP2_HUMAN, O76076
Function: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and
inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production

     Genatlas biochemistry entry for WISP2:
WNT1 inducible signaling pathway protein 2,connective tissue growth factor family,expressed in adult
kidney,testis,fetal lung,ovary,heart osteoblasts and fibroblasts,with a reduced expression in colon tumors,involved in
modulating bone turnover

miRNA
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Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WISP2
2 QIAGEN miScript miRNA Assays for microRNAs that regulate WISP2:
hsa-miR-1184 hsa-miR-3065-3p
SwitchGear 3'UTR luciferase reporter plasmid: WISP2 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WISP2 (see all 7)
OriGene shRNA RFP: WISP2
OriGene siRNA: WISP2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WISP2

Gene Editing
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Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WISP2 (see all 3)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WISP2 

Cell Line
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Search LifeMap BioReagents cell lines for WISP2

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WISP2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005520insulin-like growth factor binding IEA--


WISP2 for ontologies           About GeneDecksing



Pathways & Interactions
for WISP2 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WISP2

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/6 Interacting proteins for WISP2 (O760763 ENSP000001909834) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
IGF1P050193, ENSP000003026654I2D: score=1 STRING: ENSP00000302665
IGF1RP080693I2D: score=1 
HDAC1ENSP000003626494STRING: ENSP00000362649
HDAC3ENSP000003029674STRING: ENSP00000302967
IGF2ENSP000003382974STRING: ENSP00000338297
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001558regulation of cell growth IEA--
GO:0007155cell adhesion IEA--
GO:0007165signal transduction TAS9843955
GO:0007267cell-cell signaling TAS9843955
GO:0008285negative regulation of cell proliferation ----


WISP2 for ontologies           About GeneDecksing



Drugs & Compounds
for WISP2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

WISP2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WISP2
5 Novoseek chemical compound relationships for WISP2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen 36 13 12659671 (4), 10944450 (2), 17308090 (1), 15743834 (1) (see all 5)
cycloheximide 26.9 3 10944450 (1), 12951045 (1)
heparin 9.1 2 10358067 (1), 11584015 (1)
cysteine 8.4 1 15579080 (1)
progesterone 8.21 4 12659671 (3), 15743834 (1)

Search CenterWatch for drugs/clinical trials and news about WISP2 

Transcripts
for WISP2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for WISP2 gene: 
NM_003881.2  

Unigene Cluster for WISP2:

WNT1 inducible signaling pathway protein 2
Hs.592145  [show with all ESTs]
Unigene Representative Sequence: AK074695
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000372868 ENST00000372865(uc002xmq.3) ENST00000497421(uc002xmo.1)
ENST00000190983(uc002xmp.3) ENST00000465000 ENST00000471629

miRNA
Products:     		 OriGene 3'-UTR Clone: WISP2
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WISP2
2 QIAGEN miScript miRNA Assays for microRNAs that regulate WISP2:
hsa-miR-1184 hsa-miR-3065-3p
SwitchGear 3'UTR luciferase reporter plasmid: WISP2 3' UTR sequence
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WISP2 (see all 7)
OriGene shRNA RFP: WISP2
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WISP2
Clone
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: WISP2 (NM_003881)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WISP2 
Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WISP2

Additional cDNA sequence: 

AF074604.1 AF083500.1 AK074695.1 AK313853.1 AY358915.1 BC017782.2 BC058074.1 BC064379.1 

7 DOTS entries:

DT.101978124  DT.100027401  DT.100788404  DT.120810299  DT.40316146  DT.120810352  DT.40246004 

24/91 AceView cDNA sequences (see all 91):

NM_003881 CD517077 AF083500 BX327577 BU539788 CR603485 AY358915 BQ002854 
AI472684 BF516162 BM751866 BC064379 BU539040 CD515450 BU944681 AI081658 
BU538606 AA861514 AA385680 BC017782 BQ279131 BU857027 AK129660 BX280886 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WISP2 (see all 6)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1:        -                       -     -     -                                 
SP2:                                -     -     -                                 
SP3:                                      -     -     -     -                     
SP4:                                      -     -                                 
SP5:                                                                              


ECgene alternative splicing isoforms for WISP2

Expression
for WISP2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WISP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACACGGGCG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

WISP2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
6 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
AdiposeVascular AdiposeStromal Vascular Preadipocyte Progenitor CellsAdipose
AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
OvaryAntral FollicleCumulus CellsOvary
OvaryPrimary FollicleGranulosa CellsOvary
TestisSeminiferous TubulesMature Sertoli CellsTestis
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells 
NameCategory
PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
PureStem™ progenitor W8 (Embryonic Progenitor Cell)

See WISP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WISP2

SOURCE GeneReport for Unigene cluster: Hs.592145

UniProtKB/Swiss-Prot: WISP2_HUMAN, O76076
Tissue specificity: Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart

    SABiosciences Expression via Pathway-Focused PCR Arrays including WISP2: 
          Estrogen Receptor Signaling in human mouse rat
          WNT Signaling Targets in human mouse rat

Primer
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In Situ
Assay Products: 
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Orthologs
for WISP2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for WISP2 gene from 4/12 species (see all 12)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves WISP21 WNT1 inducible signaling pathway protein 2 68.39(n)
63.36(a)		   419192  XM_417370.3  XP_417370.3 
lizard
(Anolis carolinensis)		 Reptilia WISP26
 --
 52(a)
 1 ↔ 1
 4(143908658-143916846)
zebrafish
(Danio rerio)		 Actinopterygii wisp26
 WNT1 inducible signaling pathway protein 2
 31(a)
 1 ↔ 1
 23(26281025-26291197)
fruit fly
(Drosophila melanogaster)		 Insecta Ccn6
 Ccn
 9(a)
 1 → many
 3L(17683115-17741939)


ENSEMBL Gene Tree for WISP2 (if available)
TreeFam Gene Tree for WISP2 (if available) 

Paralogs
for WISP2 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for WISP2 gene
NOV2  CTGF2  WISP32  CYR612  WISP12  
3 SIMAP similar genes for WISP2 using alignment to 2 protein entries:     WISP2_HUMAN (see all proteins):
NOV    CTGF    WISP1

WISP2 for paralogs           About GeneDecksing



Genomic Variants
for WISP2 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/318 NCBI SNPs in WISP2 are shown (see all 318)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 20 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs61038391,2
C,F,H,--43341905(+) CCTCCT/CGGGTT 1 -- us2k16Minor allele frequency- C:0.43NA CSA 14
rs360299291,2
C,F,--43341963(+) GTGCAC/TCCACC 1 -- us2k17Minor allele frequency- T:0.18NA WA EA 366
rs1439114901,2
--43341970(+) CACCAC/TGTCCG 1 -- us2k10--------
rs759181371,2
C,--43342028(+) TGGCCA/CGGCTG 1 -- us2k10--------
rs1924955761,2
--43342041(+) CTTGAA/GCTCCT 1 -- us2k10--------
rs60317581,2
C,F,A,H,--43342049(+) CCTGAC/TCTCAG 1 -- us2k114Minor allele frequency- T:0.47NA WA CSA EA 377
rs1421471621,2
--43342150(+) ATGAAA/CGCAGA 1 -- us2k10--------
rs793009271,2
C,F,--43342203(+) TTTACG/AAAACT 1 -- us2k13Minor allele frequency- A:0.04WA CSA 122
rs1474134191,2
--43342291(+) GGTAAA/GTGCAA 1 -- us2k10--------
rs1834812591,2
--43342480(+) TTAAAA/GGATCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for WISP2 (43343485 - 43357150 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WISP2
     1 CNV: 6111

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WISP2
DNA2.0 Custom Variant and Variant Library Synthesis for WISP2

Disorders / Diseases
for WISP2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
WISP2 for disorders           About GeneDecksing

OMIM gene information: 603399    OMIM disorders: --

13 diseases for WISP2:    About MalaCards
adrenal hyperplasia    wilms tumor    nephroblastoma    neurofibromatosis
breast cancer    leiomyoma    breast adenocarcinoma    pancreatic cancer
colorectal cancer    lung cancer    adenocarcinoma    pancreatitis
hepatitis

1 disease from the University of Copenhagen DISEASES database for WISP2:
Nephroblastoma

4 Novoseek disease relationships for WISP2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
wilms tumor 63.2 4 15611078 (1), 15579080 (1), 17170219 (1)
breast cancer 37.6 11 18794149 (4), 10944450 (1), 17406949 (1), 18559502 (1) (see all 6)
tumors 26.3 22 12659671 (3), 18794149 (2), 17406949 (2), 18559502 (2) (see all 10)
cancer 9.96 4 18794149 (2), 18559502 (1), 20372786 (1)

Human Genome Epidemiology (HuGE) Navigator: WISP2 (2 documents)

Export disorders for WISP2 gene to outside databases

Publications
for WISP2 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for WISP2 gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with WISP2)		    Utopia: connect your pdf to the dynamic
world of online information

  1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PubMed id 9843955)1, 2, 3, 9 Pennica D.... Levine A.J. (1998)
  2. Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. (PubMed id 10358067)1, 2, 9 Kumar S.... Lee J.C. (1999)
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  7. WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation. (PubMed id 12659671)1, 9 Banerjee S....Banerjee S.K. (2003)
  8. CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells. (PubMed id 18794149)1, 9 Banerjee S....Banerjee S.K. (2008)
  9. Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2. (PubMed id 18559502)1, 9 Dhar G....Banerjee S.K. (2008)
  10. Differential expression of the CCN family member WISP -1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implication s. (PubMed id 20372786)1, 9 Davies S.R....Jiang W.G. (2010)

External Searches for WISP2 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing WISP2 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8839 HGNC: 12770 AceView: WISP2 Ensembl:ENSG00000064205 euGenes: HUgn8839
ECgene: WISP2 H-InvDB: WISP2

Other Databases showing WISP2 gene

(According to HUGE)
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Specialized Databases showing WISP2 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for WISP2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WISP2 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for WISP2 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for WISP2 gene:
Search GeneIP for patents involving WISP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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