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Aliases for WISP2 Gene

Aliases for WISP2 Gene

  • WNT1 Inducible Signaling Pathway Protein 2 2 3 5
  • Connective Tissue Growth Factor-Related Protein 58 3 4
  • Connective Tissue Growth Factor-Like Protein 3 4
  • CCN Family Member 5 3 4
  • CTGF-L 3 4
  • CT58 3 4
  • CCN5 3 4
  • WISP-2 4
  • CTGFL 4

External Ids for WISP2 Gene

Previous GeneCards Identifiers for WISP2 Gene

  • GC20P043072
  • GC20P043981
  • GC20P044029
  • GC20P042777
  • GC20P043343
  • GC20P040085

Summaries for WISP2 Gene

Entrez Gene Summary for WISP2 Gene

  • This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

GeneCards Summary for WISP2 Gene

WISP2 (WNT1 Inducible Signaling Pathway Protein 2) is a Protein Coding gene. Diseases associated with WISP2 include breast adenocarcinoma and wilms tumor susceptibility-5. GO annotations related to this gene include heparin binding and insulin-like growth factor binding. An important paralog of this gene is NOV.

UniProtKB/Swiss-Prot for WISP2 Gene

  • May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.

Gene Wiki entry for WISP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WISP2 Gene

Genomics for WISP2 Gene

Regulatory Elements for WISP2 Gene

Genomic Location for WISP2 Gene

Chromosome:
20
Start:
44,714,844 bp from pter
End:
44,728,509 bp from pter
Size:
13,666 bases
Orientation:
Plus strand

Genomic View for WISP2 Gene

Genes around WISP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WISP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WISP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WISP2 Gene

Proteins for WISP2 Gene

  • Protein details for WISP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76076-WISP2_HUMAN
    Recommended name:
    WNT1-inducible-signaling pathway protein 2
    Protein Accession:
    O76076
    Secondary Accessions:
    • B2R9N4
    • E1P612
    • Q6PEG3

    Protein attributes for WISP2 Gene

    Size:
    250 amino acids
    Molecular mass:
    26825 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WISP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WISP2 Gene

Proteomics data for WISP2 Gene at MOPED

Post-translational modifications for WISP2 Gene

No Post-translational modifications

Other Protein References for WISP2 Gene

Antibody Products

No data available for DME Specific Peptides for WISP2 Gene

Domains & Families for WISP2 Gene

Gene Families for WISP2 Gene

Suggested Antigen Peptide Sequences for WISP2 Gene

Graphical View of Domain Structure for InterPro Entry

O76076

UniProtKB/Swiss-Prot:

WISP2_HUMAN :
  • Contains 1 IGFBP N-terminal domain.
  • Belongs to the CCN family.
Domain:
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 TSP type-1 domain.
  • Contains 1 VWFC domain.
Family:
  • Belongs to the CCN family.
genes like me logo Genes that share domains with WISP2: view

Function for WISP2 Gene

Molecular function for WISP2 Gene

GENATLAS Biochemistry:
WNT1 inducible signaling pathway protein 2,connective tissue growth factor family,expressed in adult kidney,testis,fetal lung,ovary,heart osteoblasts and fibroblasts,with a reduced expression in colon tumors,involved in modulating bone turnover
UniProtKB/Swiss-Prot Function:
May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.

Gene Ontology (GO) - Molecular Function for WISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IBA --
genes like me logo Genes that share ontologies with WISP2: view
genes like me logo Genes that share phenotypes with WISP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WISP2

miRNA for WISP2 Gene

miRTarBase miRNAs that target WISP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WISP2 Gene

Localization for WISP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WISP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WISP2 Gene COMPARTMENTS Subcellular localization image for WISP2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for WISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WISP2: view

Pathways & Interactions for WISP2 Gene

SuperPathways for WISP2 Gene

No Data Available

Interacting Proteins for WISP2 Gene

Gene Ontology (GO) - Biological Process for WISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA --
GO:0007267 cell-cell signaling TAS 9843955
genes like me logo Genes that share ontologies with WISP2: view

No data available for Pathways by source and SIGNOR curated interactions for WISP2 Gene

Drugs & Compounds for WISP2 Gene

(4) Drugs for WISP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for WISP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WISP2: view

Transcripts for WISP2 Gene

Unigene Clusters for WISP2 Gene

WNT1 inducible signaling pathway protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WISP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:
SP6:

Relevant External Links for WISP2 Gene

GeneLoc Exon Structure for
WISP2
ECgene alternative splicing isoforms for
WISP2

Expression for WISP2 Gene

mRNA expression in normal human tissues for WISP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WISP2 Gene

This gene is overexpressed in Artery - Tibial (x8.8), Artery - Aorta (x5.4), Artery - Coronary (x5.2), and Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for WISP2 Gene

This gene is overexpressed in Urine (23.9), Testis (18.5), Ovary (8.0), Lung (7.4), and Gallbladder (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WISP2 Gene



SOURCE GeneReport for Unigene cluster for WISP2 Gene Hs.592145

mRNA Expression by UniProt/SwissProt for WISP2 Gene

O76076-WISP2_HUMAN
Tissue specificity: Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart.
genes like me logo Genes that share expression patterns with WISP2: view

Protein tissue co-expression partners for WISP2 Gene

Primer Products

In Situ Assay Products

Orthologs for WISP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WISP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WISP2 35
  • 87.07 (n)
  • 85.6 (a)
WISP2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WISP2 35
  • 88.13 (n)
  • 85.6 (a)
WISP2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wisp2 35
  • 80 (n)
  • 73.2 (a)
Wisp2 16
Wisp2 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WISP2 35
  • 99.47 (n)
  • 99.6 (a)
WISP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wisp2 35
  • 78.4 (n)
  • 70.8 (a)
oppossum
(Monodelphis domestica)
Mammalia WISP2 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WISP2 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves WISP2 35
  • 68.21 (n)
  • 64.95 (a)
WISP2 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WISP2 36
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wisp2 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
Species with no ortholog for WISP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WISP2 Gene

ENSEMBL:
Gene Tree for WISP2 (if available)
TreeFam:
Gene Tree for WISP2 (if available)

Paralogs for WISP2 Gene

Paralogs for WISP2 Gene

(3) SIMAP similar genes for WISP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WISP2: view

Variants for WISP2 Gene

Sequence variations from dbSNP and Humsavar for WISP2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_049566 -

Structural Variations from Database of Genomic Variants (DGV) for WISP2 Gene

Variant ID Type Subtype PubMed ID
nsv458985 CNV Gain 19166990
nsv179790 CNV Loss 16902084
esv1001878 CNV Gain 20482838

Variation tolerance for WISP2 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WISP2 Gene

HapMap Linkage Disequilibrium report
WISP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WISP2 Gene

Disorders for WISP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WISP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast adenocarcinoma
  • adenocarcinoma of breast
wilms tumor susceptibility-5
  • wilms tumor
- elite association - COSMIC cancer census association via MalaCards
Search WISP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WISP2

Genetic Association Database (GAD)
WISP2
Human Genome Epidemiology (HuGE) Navigator
WISP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WISP2
genes like me logo Genes that share disorders with WISP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WISP2 Gene

Publications for WISP2 Gene

  1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PMID: 9843955) Pennica D. … Levine A.J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23 67
  2. Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications. (PMID: 20372786) Davies S.R. … Jiang W.G. (Int. J. Oncol. 2010) 3 23
  3. Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2. (PMID: 18559502) Dhar G. … Banerjee S.K. (Cancer Res. 2008) 3 23
  4. CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells. (PMID: 18794149) Banerjee S. … Banerjee S.K. (Cancer Res. 2008) 3 23
  5. Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer. (PMID: 17406949) Davies S.R. … Jiang W.G. (Ann. Surg. Oncol. 2007) 3 23

Products for WISP2 Gene

Sources for WISP2 Gene

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