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Aliases for WISP1 Gene

Aliases for WISP1 Gene

  • WNT1 Inducible Signaling Pathway Protein 1 2 3
  • CCN Family Member 4 3 4
  • CCN4 3 4
  • Wnt-1 Inducible Signaling Pathway Protein 1 3
  • WNT1-Inducible-Signaling Pathway Protein 1 3
  • WNT1 Induced Secreted Protein 1 3
  • Wnt-1-Induced Secreted Protein 4
  • CTC-458A3.8 3
  • WISP1tc 3
  • WISP1c 3
  • WISP1i 3
  • WISP-1 4

External Ids for WISP1 Gene

Previous GeneCards Identifiers for WISP1 Gene

  • GC08P132932
  • GC08P134290
  • GC08P133874
  • GC08P134159
  • GC08P134272
  • GC08P134203
  • GC08P129523

Summaries for WISP1 Gene

Entrez Gene Summary for WISP1 Gene

  • This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for WISP1 Gene

WISP1 (WNT1 Inducible Signaling Pathway Protein 1) is a Protein Coding gene. Diseases associated with WISP1 include hemimegalencephaly. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is NOV.

UniProtKB/Swiss-Prot for WISP1 Gene

  • Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.

Gene Wiki entry for WISP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WISP1 Gene

Genomics for WISP1 Gene

Regulatory Elements for WISP1 Gene

Genomic Location for WISP1 Gene

Start:
133,191,039 bp from pter
End:
133,231,690 bp from pter
Size:
40,652 bases
Orientation:
Plus strand

Genomic View for WISP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WISP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WISP1 Gene

Proteins for WISP1 Gene

  • Protein details for WISP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95388-WISP1_HUMAN
    Recommended name:
    WNT1-inducible-signaling pathway protein 1
    Protein Accession:
    O95388
    Secondary Accessions:
    • A8KAG6
    • E7EMM5
    • Q5JBS6
    • Q5JBS7
    • Q5JBS8
    • Q9HCS3

    Protein attributes for WISP1 Gene

    Size:
    367 amino acids
    Molecular mass:
    40331 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WISP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WISP1 Gene

Proteomics data for WISP1 Gene at MOPED

Post-translational modifications for WISP1 Gene

  • Glycosylation at Asn86, Asn143, Asn284, and Asn343
  • Modification sites at PhosphoSitePlus

Other Protein References for WISP1 Gene

Antibody Products

Protein Products

No data available for DME Specific Peptides for WISP1 Gene

Domains for WISP1 Gene

Graphical View of Domain Structure for InterPro Entry

O95388

UniProtKB/Swiss-Prot:

WISP1_HUMAN :
  • O95388
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 TSP type-1 domain.
  • Contains 1 VWFC domain.
Family:
  • Belongs to the CCN family.
genes like me logo Genes that share domains with WISP1: view

No data available for Gene Families for WISP1 Gene

Function for WISP1 Gene

Molecular function for WISP1 Gene

GENATLAS Biochemistry:
WNT1 inducible signaling pathway protein 1,connective tissue growth factor family,expressed in adult heart,kidney,lung,pancreas,placenta,ovary,small intestine and spleen,overexpressed in colon tumors
UniProtKB/Swiss-Prot Function:
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.

Gene Ontology (GO) - Molecular Function for WISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IBA --
GO:0005515 protein binding --
GO:0005520 insulin-like growth factor binding IEA --
GO:0008201 heparin binding IBA --
genes like me logo Genes that share ontologies with WISP1: view

Phenotypes for WISP1 Gene

genes like me logo Genes that share phenotypes with WISP1: view

Animal Models for WISP1 Gene

MGI Knock Outs for WISP1:

Animal Model Products

miRNA for WISP1 Gene

miRTarBase miRNAs that target WISP1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WISP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WISP1 Gene

Localization for WISP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WISP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WISP1 Gene COMPARTMENTS Subcellular localization image for WISP1 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 3
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space NAS 9843955
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with WISP1: view

Pathways for WISP1 Gene

SuperPathways for WISP1 Gene

No Data Available

PCR Array Products

Interacting Proteins for WISP1 Gene

Gene Ontology (GO) - Biological Process for WISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007155 cell adhesion IBA --
GO:0007165 signal transduction TAS 9843955
GO:0007267 cell-cell signaling TAS 9843955
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with WISP1: view

No data available for Pathways by source for WISP1 Gene

Compounds for WISP1 Gene

(1) Novoseek inferred chemical compound relationships for WISP1 Gene

Compound -log(P) Hits PubMed IDs
cysteine 0.061 1
genes like me logo Genes that share compounds with WISP1: view

Transcripts for WISP1 Gene

Unigene Clusters for WISP1 Gene

WNT1 inducible signaling pathway protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WISP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WISP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1:
SP2: -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for WISP1 Gene

GeneLoc Exon Structure for
WISP1
ECgene alternative splicing isoforms for
WISP1

Expression for WISP1 Gene

mRNA expression in normal human tissues for WISP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for WISP1 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WISP1 Gene

SOURCE GeneReport for Unigene cluster for WISP1 Gene Hs.492974

mRNA Expression by UniProt/SwissProt for WISP1 Gene

O95388-WISP1_HUMAN
Tissue specificity: Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma
genes like me logo Genes that share expressions with WISP1: view

Expression partners for WISP1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for WISP1 Gene

Orthologs for WISP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WISP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WISP1 35
  • 83.47 (n)
  • 84.47 (a)
WISP1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WISP1 35
  • 86.1 (n)
  • 88.29 (a)
WISP1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wisp1 35
  • 83.47 (n)
  • 83.65 (a)
Wisp1 16
Wisp1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WISP1 35
  • 99.55 (n)
  • 99.46 (a)
WISP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wisp1 35
  • 83.38 (n)
  • 83.11 (a)
oppossum
(Monodelphis domestica)
Mammalia WISP1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WISP1 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves WISP1 35
  • 69.45 (n)
  • 65.46 (a)
WISP1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WISP1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wisp1 35
  • 66.2 (n)
  • 62.85 (a)
zebrafish
(Danio rerio)
Actinopterygii wisp1b 35
  • 59.46 (n)
  • 59.27 (a)
wisp1a 36
  • 57 (a)
OneToMany
wisp1b 36
  • 58 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
Species with no ortholog for WISP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WISP1 Gene

ENSEMBL:
Gene Tree for WISP1 (if available)
TreeFam:
Gene Tree for WISP1 (if available)

Paralogs for WISP1 Gene

Paralogs for WISP1 Gene

Selected SIMAP similar genes for WISP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WISP1: view

Variants for WISP1 Gene

Sequence variations from dbSNP and Humsavar for WISP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs753722 -- 133,203,703(+) ATGAC(C/G)TGCCC intron-variant
rs753723 -- 133,203,757(+) TCTTA(C/G)AAGAG intron-variant
rs754958 -- 133,226,528(-) CCAAG(C/T)GCAGA intron-variant
rs873873 -- 133,204,955(+) TCCCA(C/G)GCCCC intron-variant
rs956963 -- 133,196,906(-) AGCCA(A/C)CTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WISP1 Gene

Variant ID Type Subtype PubMed ID
nsv512967 CNV Insertion 21212237
esv1498080 CNV Insertion 17803354
esv1593495 CNV Insertion 17803354

Relevant External Links for WISP1 Gene

HapMap Linkage Disequilibrium report
WISP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WISP1 Gene

Disorders for WISP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for WISP1 Gene in MalaCards »

(1) Diseases for WISP1 Gene including...

(1) University of Copenhagen DISEASES for WISP1 Gene

(10) Novoseek inferred disease relationships for WISP1 Gene

Disease -log(P) Hits PubMed IDs
wilms tumor 52.2 2
colon tumor 38.7 2
colorectal carcinoma 22.5 1
tumors 22 15
metastasis 18.5 4

Relevant External Links for WISP1

Genetic Association Database (GAD)
WISP1
Human Genome Epidemiology (HuGE) Navigator
WISP1
genes like me logo Genes that share disorders with WISP1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for WISP1 Gene

Publications for WISP1 Gene

  1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PMID: 9843955) Pennica D. … Levine A.J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women. (PMID: 17593496) Urano T. … Inoue S. (J. Bone Miner. Metab. 2007) 3 23 48
  3. WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. (PMID: 11782444) Su F. … Levine A.J. (Genes Dev. 2002) 3 4 23
  4. WISP-1 binds to decorin and biglycan. (PMID: 11598131) Desnoyers L. … Pennica D. (J. Biol. Chem. 2001) 3 4 23
  5. A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. (PMID: 11571650) Tanaka S. … Sugimachi K. (Oncogene 2001) 3 4 23

Products for WISP1 Gene

Sources for WISP1 Gene

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