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WISP1 Gene

protein-coding   GIFtS: 59
GCID: GC08P134203

WNT1 Inducible Signaling Pathway Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WNT1 Inducible Signaling Pathway Protein 11 2     WISP1tc2
CCN42 3     Wnt-1 Inducible Signaling Pathway Protein 12
CCN Family Member 42 3     WNT1 Induced Secreted Protein 12
CTC-458A3.82     WNT1-Inducible-Signaling Pathway Protein 12
WISP1c2     WISP-13
WISP1i2     Wnt-1-Induced Secreted Protein3

External Ids:    HGNC: 127691   Entrez Gene: 88402   Ensembl: ENSG000001044157   OMIM: 6033985   UniProtKB: O953883   

Export aliases for WISP1 gene to outside databases

Previous GC identifers: GC08P132932 GC08P134290 GC08P133874 GC08P134159 GC08P134272 GC08P129523


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WISP1 Gene:
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the
connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated
signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by
four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C
module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1
signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast
cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a
family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly
prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates
p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the
mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
(provided by RefSeq, Mar 2011)

GeneCards Summary for WISP1 Gene:
WISP1 (WNT1 inducible signaling pathway protein 1) is a protein-coding gene. Diseases associated with WISP1 include hemimegalencephaly, and skin melanoma. GO annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is WISP2.

UniProtKB/Swiss-Prot: WISP1_HUMAN, O95388
Function: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates
p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the
anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts
occurs through the proteoglycans, decorin and biglycan

Gene Wiki entry for WISP1 (WNT1-inducible-signaling pathway protein 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WISP1 gene promoter:
         HOXA9B   HOXA9   MAZR   HTF   Evi-1   Egr-2   IRF-2   Meis-1a   Meis-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWISP1 promoter sequence
   Search Chromatin IP Primers for WISP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WISP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.22   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24.22

WISP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WISP1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P134203:  view genomic region     (about GC identifiers)

Start:
134,203,282 bp from pter      End:
134,243,933 bp from pter
Size:
40,652 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WISP1_HUMAN, O95388 (See protein sequence)
Recommended Name: WNT1-inducible-signaling pathway protein 1 precursor  
Size: 367 amino acids; 40331 Da
Secondary accessions: A8KAG6 E7EMM5 Q5JBS6 Q5JBS7 Q5JBS8 Q9HCS3
Alternative splicing: 5 isoforms:  O95388-1   O95388-2   O95388-3   O95388-4   O95388-5   (Ref.3 (AAP43926) sequence is in conflict in position: 155:Q->QQVLHPLQV)

Explore the universe of human proteins at neXtProt for WISP1: NX_O95388

Explore proteomics data for WISP1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn86, Asn143, Asn284, Asn343

  • See WISP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001191798.1  NP_001191799.1  NP_003873.1  NP_543028.1  

    ENSEMBL proteins: 
     ENSP00000367093   ENSP00000250160   ENSP00000429185   ENSP00000427744   ENSP00000220856  
     ENSP00000367094  

    WISP1 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for WISP1
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    Cloud-Clone Corp. Proteins for WISP1

    WISP1 Antibody Products:

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    WISP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for WISP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR006207 Cys_knot_C
     IPR000867 IGFBP-like
     IPR012395 IGFBP_CNN
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry O95388

    ProtoNet protein and cluster: O95388

    5 Blocks protein domains:
    IPB000867 Insulin-like growth factor-binding protein
    IPB000884 Thrombospondin
    IPB001007 von Willebrand factor
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: WISP1_HUMAN, O95388
    Similarity: Belongs to the CCN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 TSP type-1 domain
    Similarity: Contains 1 VWFC domain


    WISP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WISP1_HUMAN, O95388
    Function: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates
    p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the
    anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts
    occurs through the proteoglycans, decorin and biglycan

         Genatlas biochemistry entry for WISP1:
    WNT1 inducible signaling pathway protein 1,connective tissue growth factor family,expressed in adult
    heart,kidney,lung,pancreas,placenta,ovary,small intestine and spleen,overexpressed in colon tumors

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005520insulin-like growth factor binding IEA--
         
    WISP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WISP1:
     Decreased number of cells in m 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Wisp1):
     behavior/neurological 

    WISP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wisp1tm1Lex for WISP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WISP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WISP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WISP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WISP1

    miRNA
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    miRTarBase miRNAs that target WISP1:
    hsa-mir-335-5p (MIRT019070)

    Block miRNA regulation of human, mouse, rat WISP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WISP1 (see all 22):
    hsa-miR-15a hsa-miR-128 hsa-miR-29a hsa-miR-29c hsa-miR-424 hsa-miR-23a hsa-miR-24 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidWISP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WISP1
    Predesigned siRNA for gene silencing in human, mouse, rat WISP1

    Gene Editing
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    OriGene ORF clones in mouse, rat for WISP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): WISP1 (NM_003882)
    Sino Biological Human cDNA Clone for WISP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WISP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WISP1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for WISP1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WISP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WISP1_HUMAN, O95388: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    plasma membrane3
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space NAS9843955
    GO:0005737cytoplasm IDA--

    WISP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including WISP1 (see all 6): 
              Notch Signaling Targets in human mouse rat
              WNT Signaling Targets in human mouse rat
              Wound Healing in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WISP1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for WISP1 (O953883 ENSP000002501604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BGNP218103, ENSP000003273364I2D: score=1 STRING: ENSP00000327336
    DCNP075853, ENSP000000527544I2D: score=1 STRING: ENSP00000052754
    UGGT1Q9NYU23, ENSP000002592534I2D: score=2 STRING: ENSP00000259253
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS9843955
    GO:0007267cell-cell signaling TAS9843955
    GO:0016055Wnt signaling pathway IEA--

    WISP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WISP1

    1 Novoseek inferred chemical compound relationship for WISP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 0.061 1 15579080 (1)



    WISP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WISP1 gene (4 alternative transcripts): 
    NM_001204869.1  NM_001204870.1  NM_003882.3  NM_080838.2  

    Unigene Cluster for WISP1:

    WNT1 inducible signaling pathway protein 1
    Hs.492974  [show with all ESTs]
    Unigene Representative Sequence: NM_003882
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377862(uc003yuc.3 uc010meb.3 uc010mec.3 uc010med.3 uc003yud.3)
    ENST00000250160(uc003yub.3) ENST00000519433 ENST00000517423 ENST00000220856
    ENST00000377863
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WISP1 (see all 22):
    hsa-miR-15a hsa-miR-128 hsa-miR-29a hsa-miR-29c hsa-miR-424 hsa-miR-23a hsa-miR-24 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidWISP1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 4): WISP1 (NM_003882)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WISP1
    Primer
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    OriGene qPCR primer pairs and template standards for WISP1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WISP1
      QuantiTect SYBR Green Assays in human, mouse, rat WISP1
      QuantiFast Probe-based Assays in human, mouse, rat WISP1

    Additional mRNA sequence: 

    AB034725.1 AF100779.1 AK027294.1 AK293031.1 AK301508.1 AK315822.1 AY196486.1 AY196487.1 
    AY196488.1 BC074840.2 BC074841.2 EF025923.1 NR_037944.1 

    4 DOTS entries:

    DT.40115798  DT.91800804  DT.95154228  DT.121478276 

    Selected AceView cDNA sequences (see all 59):

    AI971546 NM_003882 BM720812 BU624665 BQ014978 NM_080838 BQ015101 BC074841 
    BQ007804 BC074840 BM718665 BX476382 CD676873 BM721446 BM676914 AI473336 
    BU627344 AA393740 AI372923 BE350495 BX102925 AI342382 AI983005 AA147491 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for WISP1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                                                      
    SP2:                    -                                 
    SP3:              -     -                                 
    SP4:                    -     -                           
    SP5:              -     -     -                           


    ECgene alternative splicing isoforms for WISP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WISP1 expression in normal human tissues (normalized intensities)      WISP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WISP1 Expression
    About this image


    WISP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Long Bone
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Pelvic Girdle
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
    WISP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WISP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.492974

    UniProtKB/Swiss-Prot: WISP1_HUMAN, O95388
    Tissue specificity: Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen.
    Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is
    associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous
    gastric carcinoma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WISP1 (see all 6): 
              Notch Signaling Targets in human mouse rat
              WNT Signaling Targets in human mouse rat
              Wound Healing in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for WISP1
    OriGene qSTAR qPCR primer pairs in human, mouse for WISP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WISP1
    QuantiTect SYBR Green Assays in human, mouse, rat WISP1
    QuantiFast Probe-based Assays in human, mouse, rat WISP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WISP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for WISP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wisp11 , 5 WNT1 inducible signaling pathway protein 11, 5 83.47(n)1
    83.65(a)1
      15 (29.30 cM)5
    224021  NM_018865.21  NP_061353.11 
     668913205 
    chicken
    (Gallus gallus)
    Aves WISP11 WNT1 inducible signaling pathway protein 1 69.45(n)
    65.46(a)
      420322  NM_001024579.1  NP_001019750.1 
    lizard
    (Anolis carolinensis)
    Reptilia WISP16
    WNT1 inducible signaling pathway protein 1
    65(a)
    1 ↔ 1
    4(840355-869184)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wisp11 WNT1 inducible signaling pathway protein 1 66.2(n)
    62.85(a)
      100492186  XM_002939516.2  XP_002939562.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wisp1b1 WNT1 inducible signaling pathway protein 1b 59.46(n)
    59.27(a)
      792714  NM_001113628.1  NP_001107100.1 


    ENSEMBL Gene Tree for WISP1 (if available)
    TreeFam Gene Tree for WISP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WISP1 gene
    WISP22  NOV2  CTGF2  WISP32  CYR612  
    7 SIMAP similar genes for WISP1 using alignment to 2 protein entries:     WISP1_HUMAN (see all proteins):
    wisp3 varinat    WISP3    LIBC    CTGF    NOV    WISP2
    CYR61

    WISP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WISP1 (see all 1021)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007478241,2
    --134206536(+) GTCTG-/GTGTGTG 5 -- int10--------
    rs2009613661,2
    C--134206537(+) GTGTG-/GT/TG 
            
    GTGTG
    5 -- int10--------
    rs362111571,2
    C--134214088(+) CTCAA-/AAAAG 
            
    AAAAG
    5 -- int11Minor allele frequency- AAAAG:0.50CSA 2
    rs1456500351,2
    C--134214088(+) CTCAA-/AAAAG 
            
    AAAAG
    5 -- int10--------
    rs58951791,2
    C--134214092(+) gaaaa-/GAAAA 
            
    aaaCC
    5 -- int1 trp31Minor allele frequency- GAAAA:0.00NA 2
    rs339233751,2
    C--134216735(+) CAAGG-/GTTGCT 5 -- int10--------
    rs339838961,2
    C--134220238(+) AGCTG-/TTTTTT 5 -- int10--------
    rs722293641,2
    C--134222630(+) AGGGG-/GTTGTGT 5 -- int10--------
    rs760216421,2
    C--134222872(+) TTTTTC/TTGGCC 5 -- int10--------
    rs557335251,2
    C--134225396(+) TGAGTC/-CCTCC 5 -- int13Minor allele frequency- -:0.00NA CSA 6

    HapMap Linkage Disequilibrium report for WISP1 (134203282 - 134243933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WISP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv512967CNV Insertion21212237
    esv1593495CNV Insertion17803354
    esv1498080CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WISP1
    DNA2.0 Custom Variant and Variant Library Synthesis for WISP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603398    OMIM disorders: --

    Selected diseases for WISP1 (see all 30):    About MalaCards
    hemimegalencephaly    skin melanoma    nephroblastoma    fibromatosis
    idiopathic pulmonary fibrosis    wilms tumor    rabies    pulmonary fibrosis
    neurofibromatosis    narcolepsy    chondrosarcoma    esophageal squamous cell carcinoma
    osteoarthritis    colorectal cancer    graves' disease    meningitis
    melanoma    cholangiocarcinoma    asthma    choroiditis

    1 disease from the University of Copenhagen DISEASES database for WISP1:
    Nephroblastoma

    WISP1 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for WISP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 52.2 3 15611078 (1), 15579080 (1)
    colon tumor 38.7 2 9843955 (1), 11598131 (1)
    colorectal carcinoma 22.5 1 16041507 (1)
    tumors 22 19 11751417 (4), 19339243 (2), 17406949 (2), 19069651 (1) (see all 10)
    metastasis 18.5 4 12865923 (2), 12529380 (1), 20506641 (1)
    colorectal cancer 12.4 3 20372786 (2), 17054584 (1)
    glioma 10.5 2 15041728 (2)
    cancer lung 9.58 12 17579708 (6), 19069651 (4), 12529380 (2)
    colon cancer 9.12 3 17054584 (2), 9843955 (1)
    breast cancer 3.82 13 20506641 (4), 11751417 (2), 17406949 (1)

    Genetic Association Database (GAD): WISP1
    Human Genome Epidemiology (HuGE) Navigator: WISP1 (10 documents)

    Export disorders for WISP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WISP1 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with WISP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. (PubMed id 9843955)1, 2, 3, 9 Pennica D.... Levine A.J. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. (PubMed id 11782444)1, 2, 9 Su F.... Levine A.J. (Genes Dev. 2002)
    3. WISP-1 binds to decorin and biglycan. (PubMed id 11598131)1, 2, 9 Desnoyers L.... Pennica D. (J. Biol. Chem. 2001)
    4. Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women. (PubMed id 17593496)1, 4, 9 Urano T....Inoue S. (J. Bone Miner. Metab. 2007)
    5. A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. (PubMed id 11571650)1, 2, 9 Tanaka S.... Sugimachi K. (Oncogene 2001)
    6. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PubMed id 19926868)1, 4 Sharma S....Weiss S.T. (Am. J. Respir. Crit. Care Med. 2010)
    7. Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PubMed id 20403915)1, 4 Frank B....Brenner H. (Carcinogenesis 2010)
    8. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8840 HGNC: 12769 AceView: WISP1 Ensembl:ENSG00000104415 euGenes: HUgn8840
    ECgene: WISP1 H-InvDB: WISP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WISP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WISP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WISP1 gene:
    Search GeneIP for patents involving WISP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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