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WIPI2 Gene

protein-coding   GIFtS: 55
GCID: GC07P005229

WD Repeat Domain, Phosphoinositide Interacting 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain, Phosphoinositide Interacting 21 2     Atg212
WIPI-22 3     WD Repeat Domain Phosphoinositide-Interacting Protein 22
WIPI49-Like Protein 22 3     WD40 Repeat Protein Interacting With Phosphoinositides 22
ATG18B2     

External Ids:    HGNC: 322251   Entrez Gene: 261002   Ensembl: ENSG000001579547   OMIM: 6092255   UniProtKB: Q9Y4P83   

Export aliases for WIPI2 gene to outside databases

Previous GC identifers: GC07P005006 GC07P005196 GC07P005144


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WIPI2 Gene:
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of
multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein
interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller
structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 (PubMed
15602573)).(supplied by OMIM, Mar 2008)

GeneCards Summary for WIPI2 Gene:
WIPI2 (WD repeat domain, phosphoinositide interacting 2) is a protein-coding gene. GO annotations related to this gene include phosphatidylinositol-3,5-bisphosphate binding and phosphatidylinositol-3-phosphate binding. An important paralog of this gene is WIPI1.

UniProtKB/Swiss-Prot: WIPI2_HUMAN, Q9Y4P8
Function: Probable early component of the autophagy machinery being involved in formation of preautophagosomal
structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P

Gene Wiki entry for WIPI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WIPI2 gene promoter:
         FAC1   Sp1   p53   GCNF   GCNF-1   Nkx2-5   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): WIPI2 promoter sequence
   Search Chromatin IP Primers for WIPI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WIPI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

WIPI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WIPI2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P005229:  view genomic region     (about GC identifiers)

Start:
5,229,819 bp from pter      End:
5,273,486 bp from pter
Size:
43,668 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 5,276,190-5,319,841     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WIPI2_HUMAN, Q9Y4P8 (See protein sequence)
Recommended Name: WD repeat domain phosphoinositide-interacting protein 2  
Size: 454 amino acids; 49408 Da
Subunit: Interacts with TECPR1
Secondary accessions: B3KNC2 Q5MNZ8 Q6FI96 Q75L50 Q96IE4 Q9Y364
Alternative splicing: 6 isoforms:  Q9Y4P8-1   Q9Y4P8-2   Q9Y4P8-3   Q9Y4P8-4   Q9Y4P8-5   Q9Y4P8-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WIPI2: NX_Q9Y4P8

Explore proteomics data for WIPI2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys223, Lys331, Lys341
  • Modification sites at PhosphoSitePlus

  • See WIPI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001028690.1  NP_001028691.1  NP_001028692.1  NP_001265228.1  NP_056425.1  NP_057087.2  

    ENSEMBL proteins: 
     ENSP00000288828   ENSP00000384945   ENSP00000385297   ENSP00000371821   ENSP00000429654  

    WIPI2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for WIPI2

     
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    antibodies-online proteins for WIPI2 (6 products) 

     
    antibodies-online peptides for WIPI2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y4P8

    ProtoNet protein and cluster: Q9Y4P8

    UniProtKB/Swiss-Prot: WIPI2_HUMAN, Q9Y4P8
    Similarity: Belongs to the WD repeat SVP1 family
    Similarity: Contains 3 WD repeats


    Find genes that share domains with WIPI2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WIPI2_HUMAN, Q9Y4P8
    Function: Probable early component of the autophagy machinery being involved in formation of preautophagosomal
    structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0032266phosphatidylinositol-3-phosphate binding IDA--
    GO:0080025phosphatidylinositol-3,5-bisphosphate binding IDA--
         
    Find genes that share ontologies with WIPI2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WIPI2:
     Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WIPI2

    miRNA
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    miRTarBase miRNAs that target WIPI2:
    hsa-let-7a-5p (MIRT052545), hsa-mir-615-3p (MIRT040290), hsa-mir-505-5p (MIRT037966)

    Block miRNA regulation of human, mouse, rat WIPI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WIPI2 (see all 68):
    hsa-miR-3678-3p hsa-miR-376b hsa-miR-15a hsa-miR-605 hsa-miR-298 hsa-miR-4273 hsa-miR-186* hsa-miR-4255
    SwitchGear 3'UTR luciferase reporter plasmidWIPI2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WIPI2_HUMAN, Q9Y4P8: Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side.
    Note=Enriched at preautophagosomal structure membranes in response to ptdIns3P
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus4
    vacuole3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000421autophagic vacuole membrane IBA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005776NOT colocalizes with autophagic vacuole IDA--

    Find genes that share ontologies with WIPI2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WIPI2
    Interactions:

        Search GeneGlobe Interaction Network for WIPI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WIPI2 (Q9Y4P82, 3 ENSP000002888284) via UniProtKB, MINT, STRING, and/or I2D (see all 625)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IMP--
    GO:0000046NOT autophagic vacuole fusion IMP--

    Find genes that share ontologies with WIPI2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WIPI2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WIPI2 gene (6 alternative transcripts): 
    NM_001033518.1  NM_001033519.1  NM_001033520.1  NM_001278299.1  NM_015610.3  NM_016003.3  

    Unigene Cluster for WIPI2:

    WD repeat domain, phosphoinositide interacting 2
    Hs.122363  [show with all ESTs]
    Unigene Representative Sequence: NM_015610
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288828(uc003snv.3 uc003snw.3 uc003snx.3 uc003sny.3 uc010ksv.3 uc003soa.3)
    ENST00000401525 ENST00000404704 ENST00000466014 ENST00000485854 ENST00000382384
    ENST00000496867 ENST00000475309(uc003snz.3) ENST00000484262 ENST00000465102
    ENST00000480238 ENST00000488359 ENST00000471851 ENST00000479690
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WIPI2 (see all 68):
    hsa-miR-3678-3p hsa-miR-376b hsa-miR-15a hsa-miR-605 hsa-miR-298 hsa-miR-4273 hsa-miR-186* hsa-miR-4255
    SwitchGear 3'UTR luciferase reporter plasmidWIPI2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat WIPI2

    Additional mRNA sequence: 

    AF151808.1 AK023041.1 AK024279.1 AK124974.1 AK125007.1 AK315468.1 AL080155.1 AY691425.1 
    AY691426.1 BC004116.2 BC007596.1 BC021012.1 BC021068.1 BC021200.2 BX537624.1 CR533530.1 

    Selected DOTS entries (see all 27):

    DT.75122586  DT.91874825  DT.91757688  DT.100819593  DT.95267440  DT.100669928  DT.443083  DT.40121362 
    DT.97795995  DT.100819587  DT.95267443  DT.100819597  DT.100819601  DT.100819585  DT.100819592  DT.100039964 
    DT.100639112  DT.100819589  DT.121121186  DT.121121200  DT.91757670  DT.91757689  DT.95267445  DT.95330684 

    Selected AceView cDNA sequences (see all 567):

    BM696380 AA291497 CR621388 CA433701 BC021068 BM669123 AI140076 BM737651 
    CB242526 AI817769 NM_015610 AA143126 AI304766 AW262778 BM908458 CK299605 
    BG236099 CR624233 AI074158 CK821391 AW051439 BQ027439 AA971851 AI348224 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WIPI2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b
    SP1:        -                 -     -                                               -                 -                           
    SP2:        -     -           -     -                                               -                 -                           
    SP3:        -     -           -     -                                               -                 -           -               
    SP4:                                                                                -                 -           -               
    SP5:        -                 -     -                 -                                                                           


    ECgene alternative splicing isoforms for WIPI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WIPI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCTTCGGA
    WIPI2 Expression
    About this image

    WIPI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WIPI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.122363

    UniProtKB/Swiss-Prot: WIPI2_HUMAN, Q9Y4P8
    Tissue specificity: Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and
    pancreas. Expression is down-regulated in pancreatic and in kidney tumors

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WIPI2 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wipi21 , 5 WD repeat domain, phosphoinositide interacting 21, 5 88.15(n)1
    97.02(a)1
      5 (81.53 cM)5
    747811  NM_178398.41  NP_848485.11 
     1426295425 
    chicken
    (Gallus gallus)
    Aves WIPI21 WD repeat domain, phosphoinositide interacting 2 81.65(n)
    94.95(a)
      416481  NM_001006162.1  NP_001006162.1 
    lizard
    (Anolis carolinensis)
    Reptilia WIPI26
    WD repeat domain, phosphoinositide interacting 2
    84(a)
    1 ↔ 1
    GL343591.1(288613-312054)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC532202 hypothetical protein MGC53220 79.44(n)    BC046705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wipi26
    WD repeat domain, phosphoinositide interacting 2
    87(a)
    1 ↔ 1
    3(40815404-40832107) ENSDARG00000037871
    fruit fly
    (Drosophila melanogaster)
    Insecta Atg181 Autophagy-specific gene 18 62.17(n)
    64.52(a)
      38913  NM_001274636.1  NP_001261565.1 
    worm
    (Caenorhabditis elegans)
    Secernentea atg-181 atg-18 51.42(n)
    44.32(a)
      179246  NM_171491.3  NP_741576.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG18(YFR021W)4
    ATG181
    Phosphoinositide binding protein required for vesicle more4
    ATG181
    48.12(n)1
    39.71(a)1
      6(194812-196314)4
    8505771, 4  NP_444297.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons G18B1 G18B 44.4(n)
    38.06(a)
      829174  NM_119197.4  NP_194780.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g07918001 Os02g0791800 44.84(n)
    32.15(a)
      4330978  NM_001054896.1  NP_001048361.1 


    ENSEMBL Gene Tree for WIPI2 (if available)
    TreeFam Gene Tree for WIPI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WIPI2 gene
    WIPI12  
    1 SIMAP similar gene for WIPI2 using alignment to 2 protein entries:     WIPI2_HUMAN (see all proteins):
    WIPI1

    Find genes that share paralogs with WIPI2           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for WIPI2
    PGOHUM00000248875 PGOHUM00000237178 PGOHUM00000234858


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WIPI2 (see all 1337)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs132312981,2
    C--5227859(+) CTACTT/CGGGAG 4 -- us2k12Minor allele frequency- C:0.25NA WA 4
    rs97200141,2
    C--5227908(+) GTTGCG/AGTGAG 4 -- us2k15Minor allele frequency- A:0.10NA WA CSA 10
    rs1897024531,2
    C--5227950(+) CAAGAA/TGGTGA 4 -- us2k10--------
    rs1433175221,2
    --5228148(+) CTCCTA/GGGTTC 4 -- us2k10--------
    rs665695361,2
    C--5228175(+) TCAGTT/CTCCTG 4 -- us2k12Minor allele frequency- C:0.00NA 4
    rs715240421,2
    C--5228368(+) TTTTAT/CTTTTT 4 -- us2k12Minor allele frequency- C:0.00NA 4
    rs730461201,2
    C--5228393(+) TCTGTC/TGTCCG 4 -- us2k14Minor allele frequency- T:0.31WA NA EA 360
    rs1834592151,2
    --5228421(+) AGGTGC/TAATCT 4 -- us2k10--------
    rs47244471,2
    C,A--5228564(+) ATGTTG/AGCCAG 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs69787771,2
    C,F--5228586(+) actccT/Cgacct 4 -- us2k1 tfbs33Minor allele frequency- C:0.33NA 6

    HapMap Linkage Disequilibrium report for WIPI2 (5229819 - 5273486 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for WIPI2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2498578CNV Deletion19546169
    nsv436904CNV Insertion17901297
    nsv5627CNV Insertion18451855
    nsv830889CNV Loss17160897
    nsv887391CNV Loss21882294
    nsv887390CNV Loss21882294
    nsv887392CNV Loss21882294
    nsv823995CNV Gain20364138
    nsv8034CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WIPI2
    DNA2.0 Custom Variant and Variant Library Synthesis for WIPI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609225    OMIM disorders: --


    Find genes that share disorders with WIPI2           About GenesLikeMe

    Genetic Association Database (GAD): WIPI2

    Export disorders for WIPI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WIPI2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with WIPI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. (PubMed id 15602573)1, 2, 3 Proikas-Cezanne T....Nordheim A. (Oncogene 2004)
    2. Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes. (PubMed id 21564513)1, 2 Proikas-Cezanne T. and Robenek H. (J. Cell. Mol. Med. 2011)
    3. Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. (PubMed id 20505359)1, 2 Polson H.E.... Tooze S.A. (Autophagy 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26100 HGNC: 32225 AceView: DKFZP434J154 Ensembl:ENSG00000157954 euGenes: HUgn26100
    ECgene: WIPI2 H-InvDB: WIPI2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WIPI2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WIPI2 gene:
    Search GeneIP for patents involving WIPI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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