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Aliases for WIPI2 Gene

Aliases for WIPI2 Gene

  • WD Repeat Domain, Phosphoinositide Interacting 2 2 3 5
  • WIPI49-Like Protein 2 3 4
  • WIPI-2 3 4
  • WD40 Repeat Protein Interacting With Phosphoinositides 2 3
  • ATG18B 3
  • CGI-50 3
  • Atg21 3

External Ids for WIPI2 Gene

Previous GeneCards Identifiers for WIPI2 Gene

  • GC07P005006
  • GC07P005196
  • GC07P005229
  • GC07P005144

Summaries for WIPI2 Gene

Entrez Gene Summary for WIPI2 Gene

  • WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

GeneCards Summary for WIPI2 Gene

WIPI2 (WD Repeat Domain, Phosphoinositide Interacting 2) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Regulation of autophagy. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding and phosphatidylinositol-3,5-bisphosphate binding. An important paralog of this gene is WIPI1.

UniProtKB/Swiss-Prot for WIPI2 Gene

  • Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P.

  • Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.

Gene Wiki entry for WIPI2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIPI2 Gene

Genomics for WIPI2 Gene

Regulatory Elements for WIPI2 Gene

Promoters for WIPI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WIPI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for WIPI2 Gene

Chromosome:
7
Start:
5,190,188 bp from pter
End:
5,233,855 bp from pter
Size:
43,668 bases
Orientation:
Plus strand

Genomic View for WIPI2 Gene

Genes around WIPI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WIPI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WIPI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPI2 Gene

Proteins for WIPI2 Gene

  • Protein details for WIPI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4P8-WIPI2_HUMAN
    Recommended name:
    WD repeat domain phosphoinositide-interacting protein 2
    Protein Accession:
    Q9Y4P8
    Secondary Accessions:
    • B3KNC2
    • Q5MNZ8
    • Q6FI96
    • Q75L50
    • Q96IE4
    • Q9Y364

    Protein attributes for WIPI2 Gene

    Size:
    454 amino acids
    Molecular mass:
    49408 Da
    Quaternary structure:
    • Interacts with TECPR1, ATG16L1 and ATG5.

    Alternative splice isoforms for WIPI2 Gene

neXtProt entry for WIPI2 Gene

Proteomics data for WIPI2 Gene at MOPED

Post-translational modifications for WIPI2 Gene

  • Ubiquitination at Lys 223, Lys 331, and Lys 341
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WIPI2 (WIPI2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for WIPI2

No data available for DME Specific Peptides for WIPI2 Gene

Domains & Families for WIPI2 Gene

Gene Families for WIPI2 Gene

Protein Domains for WIPI2 Gene

Suggested Antigen Peptide Sequences for WIPI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4P8

UniProtKB/Swiss-Prot:

WIPI2_HUMAN :
  • The FRRG motif is required for recruitment to PtdIns3P.
  • Belongs to the WD repeat SVP1 family.
  • Contains 7 WD repeats.
Domain:
  • The FRRG motif is required for recruitment to PtdIns3P.
Family:
  • Belongs to the WD repeat SVP1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WIPI2: view

Function for WIPI2 Gene

Molecular function for WIPI2 Gene

UniProtKB/Swiss-Prot Function:
Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P.
UniProtKB/Swiss-Prot Function:
Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.
UniProtKB/Swiss-Prot Induction:
Expression is repressed by ZKSCAN3.

Phenotypes for WIPI2 Gene

genes like me logo Genes that share phenotypes with WIPI2: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WIPI2 Gene

Localization for WIPI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPI2 Gene

Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. {ECO:0000269 PubMed:24954904}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WIPI2 Gene COMPARTMENTS Subcellular localization image for WIPI2 gene
Compartment Confidence
cytosol 5
nucleus 5
vacuole 2
lysosome 1

Gene Ontology (GO) - Cellular Components for WIPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 colocalizes_with membrane IDA 25578879
GO:0034045 pre-autophagosomal structure membrane IDA 20505359
genes like me logo Genes that share ontologies with WIPI2: view

Pathways & Interactions for WIPI2 Gene

genes like me logo Genes that share pathways with WIPI2: view

Pathways by source for WIPI2 Gene

2 Reactome pathways for WIPI2 Gene
1 R&D Systems pathway for WIPI2 Gene

Gene Ontology (GO) - Biological Process for WIPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 mitophagy IBA --
GO:0016236 macroautophagy TAS --
GO:0034497 protein localization to pre-autophagosomal structure IBA --
genes like me logo Genes that share ontologies with WIPI2: view

No data available for SIGNOR curated interactions for WIPI2 Gene

Drugs & Compounds for WIPI2 Gene

No Compound Related Data Available

Transcripts for WIPI2 Gene

Unigene Clusters for WIPI2 Gene

WD repeat domain, phosphoinositide interacting 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WIPI2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - -
SP8: - - -
SP9: -
SP10:

Relevant External Links for WIPI2 Gene

GeneLoc Exon Structure for
WIPI2
ECgene alternative splicing isoforms for
WIPI2

Expression for WIPI2 Gene

mRNA expression in normal human tissues for WIPI2 Gene

Protein differential expression in normal tissues from HIPED for WIPI2 Gene

This gene is overexpressed in Testis (15.2) and Fetal Brain (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WIPI2 Gene



SOURCE GeneReport for Unigene cluster for WIPI2 Gene Hs.122363

mRNA Expression by UniProt/SwissProt for WIPI2 Gene

Q9Y4P8-WIPI2_HUMAN
Tissue specificity: Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.
genes like me logo Genes that share expression patterns with WIPI2: view

Protein tissue co-expression partners for WIPI2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WIPI2 Gene

Orthologs for WIPI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WIPI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WIPI2 36
  • 100 (a)
OneToOne
WIPI2 35
  • 99.54 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia WIPI2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wipi2 36
  • 95 (a)
OneToOne
Wipi2 16
Wipi2 35
  • 88.15 (n)
  • 97.02 (a)
oppossum
(Monodelphis domestica)
Mammalia WIPI2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WIPI2 36
  • 92 (a)
OneToOne
WIPI2 35
  • 88.53 (n)
  • 95.64 (a)
cow
(Bos Taurus)
Mammalia WIPI2 36
  • 94 (a)
OneToOne
WIPI2 35
  • 87.08 (n)
  • 94.04 (a)
rat
(Rattus norvegicus)
Mammalia Wipi2 35
  • 87.16 (n)
  • 97.48 (a)
chicken
(Gallus gallus)
Aves WIPI2 36
  • 94 (a)
OneToOne
WIPI2 35
  • 81.65 (n)
  • 94.95 (a)
lizard
(Anolis carolinensis)
Reptilia WIPI2 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53220 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10600 35
LOC100497399 35
  • 74.9 (n)
  • 88.45 (a)
zebrafish
(Danio rerio)
Actinopterygii wipi2 36
  • 87 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14106 35
fruit fly
(Drosophila melanogaster)
Insecta Atg18 36
  • 52 (a)
OneToMany
Atg18 35
  • 62.17 (n)
  • 64.52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005910 35
  • 64.61 (n)
  • 69.12 (a)
worm
(Caenorhabditis elegans)
Secernentea atg-18 36
  • 40 (a)
OneToMany
atg-18 35
  • 51.42 (n)
  • 44.32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG18 38
ATG18 36
  • 26 (a)
OneToMany
ATG18 35
  • 48.12 (n)
  • 39.71 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04664g 35
  • 47.36 (n)
  • 39.1 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL119W 35
  • 48.43 (n)
  • 39.74 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons G18B 35
  • 44.4 (n)
  • 38.06 (a)
rice
(Oryza sativa)
Liliopsida Os02g0791800 35
  • 44.84 (n)
  • 32.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atg18 35
  • 45.66 (n)
  • 42.63 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03441 35
  • 52.79 (n)
  • 43.93 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1716 35
Species with no ortholog for WIPI2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WIPI2 Gene

ENSEMBL:
Gene Tree for WIPI2 (if available)
TreeFam:
Gene Tree for WIPI2 (if available)

Paralogs for WIPI2 Gene

Paralogs for WIPI2 Gene

(1) SIMAP similar genes for WIPI2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for WIPI2 Gene

genes like me logo Genes that share paralogs with WIPI2: view

Variants for WIPI2 Gene

Sequence variations from dbSNP and Humsavar for WIPI2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs7904 -- 5,233,490(-) TCATC(A/G)TCCTT utr-variant-3-prime
rs11715 -- 5,231,690(-) ACAAA(C/T)AAAAT utr-variant-3-prime
rs12472 -- 5,232,546(+) GATCC(C/T)GGTCA utr-variant-3-prime
rs1134489 -- 5,217,942(+) ATTCC(A/G)GCTCA reference, synonymous-codon
rs1134491 -- 5,227,288(+) AGAGC(C/T)TTCGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for WIPI2 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv887390 CNV Loss 21882294
nsv887391 CNV Loss 21882294
nsv823995 CNV Gain 20364138
nsv5627 CNV Insertion 18451855
nsv830889 CNV Loss 17160897
esv2498578 CNV Deletion 19546169
nsv8034 CNV Gain 18304495
nsv887392 CNV Loss 21882294

Variation tolerance for WIPI2 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WIPI2 Gene

HapMap Linkage Disequilibrium report
WIPI2
Human Gene Mutation Database (HGMD)
WIPI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIPI2 Gene

Disorders for WIPI2 Gene

Relevant External Links for WIPI2

Genetic Association Database (GAD)
WIPI2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WIPI2

No disorders were found for WIPI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WIPI2 Gene

Publications for WIPI2 Gene

  1. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. (PMID: 15602573) Proikas-Cezanne T. … Nordheim A. (Oncogene 2004) 2 3 4 67
  2. PI(5)P regulates autophagosome biogenesis. (PMID: 25578879) Vicinanza M. … Rubinsztein D.C. (Mol. Cell 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. (PMID: 24954904) Dooley H.C. … Tooze S.A. (Mol. Cell 2014) 3
  5. WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells. (PMID: 24991767) Brigger D. … Tschan M.P. (Cell Death Dis 2014) 3

Products for WIPI2 Gene

Sources for WIPI2 Gene

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