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Aliases for WIPI2 Gene

Aliases for WIPI2 Gene

  • WD Repeat Domain, Phosphoinositide Interacting 2 2 3
  • WIPI49-Like Protein 2 3 4
  • WIPI-2 3 4
  • WD40 Repeat Protein Interacting With Phosphoinositides 2 3
  • WD Repeat Domain Phosphoinositide-Interacting Protein 2 3
  • ATG18B 3
  • CGI-50 3
  • Atg21 3

External Ids for WIPI2 Gene

Summaries for WIPI2 Gene

Entrez Gene Summary for WIPI2 Gene

  • WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

GeneCards Summary for WIPI2 Gene

WIPI2 (WD Repeat Domain, Phosphoinositide Interacting 2) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding and phosphatidylinositol-3,5-bisphosphate binding. An important paralog of this gene is WIPI1.

UniProtKB/Swiss-Prot for WIPI2 Gene

  • Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P.

  • Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.

Gene Wiki entry for WIPI2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIPI2 Gene

Genomics for WIPI2 Gene

Genomic Location for WIPI2 Gene

Start:
5,190,188 bp from pter
End:
5,233,855 bp from pter
Size:
43,668 bases
Orientation:
Plus strand

Genomic View for WIPI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WIPI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPI2 Gene

Regulatory Elements for WIPI2 Gene

Proteins for WIPI2 Gene

  • Protein details for WIPI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4P8-WIPI2_HUMAN
    Recommended name:
    WD repeat domain phosphoinositide-interacting protein 2
    Protein Accession:
    Q9Y4P8
    Secondary Accessions:
    • B3KNC2
    • Q5MNZ8
    • Q6FI96
    • Q75L50
    • Q96IE4
    • Q9Y364

    Protein attributes for WIPI2 Gene

    Size:
    454 amino acids
    Molecular mass:
    49408 Da
    Quaternary structure:
    • Interacts with TECPR1, ATG16L1 and ATG5.

    Alternative splice isoforms for WIPI2 Gene

neXtProt entry for WIPI2 Gene

Proteomics data for WIPI2 Gene at MOPED

Post-translational modifications for WIPI2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys223, Lys331, and Lys341

No data available for DME Specific Peptides for WIPI2 Gene

Domains for WIPI2 Gene

Gene Families for WIPI2 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WIPI2 Gene

UniProtKB/Swiss-Prot:

WIPI2_HUMAN
Domain:
  • The FRRG motif is required for recruitment to PtdIns3P.:
    • Q9Y4P8
Family:
  • Belongs to the WD repeat SVP1 family.:
    • Q9Y4P8
Similarity:
  • Contains 7 WD repeats.:
    • Q9Y4P8
genes like me logo Genes that share domains with WIPI2: view

Function for WIPI2 Gene

Molecular function for WIPI2 Gene

UniProtKB/Swiss-Prot Function: Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P.
UniProtKB/Swiss-Prot Function: Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.
UniProtKB/Swiss-Prot Induction: Expression is repressed by ZKSCAN3.

Gene Ontology (GO) - Molecular Function for WIPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21575909
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 20505359
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding IDA 20505359
genes like me logo Genes that share ontologies with WIPI2: view

Phenotypes for WIPI2 Gene

GenomeRNAi human phenotypes for WIPI2:
genes like me logo Genes that share phenotypes with WIPI2: view

miRNA for WIPI2 Gene

miRTarBase miRNAs that target WIPI2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WIPI2 Gene

Localization for WIPI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPI2 Gene

Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. {ECO:0000269 PubMed:24954904}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WIPI2 Gene COMPARTMENTS Subcellular localization image for WIPI2 gene
Compartment Confidence
cytosol 5
nucleus 4
vacuole 3

Gene Ontology (GO) - Cellular Components for WIPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IDA 22456507
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005776 NOT colocalizes_with autophagic vacuole IDA 20505359
genes like me logo Genes that share ontologies with WIPI2: view

Pathways for WIPI2 Gene

SuperPathways for WIPI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WIPI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IMP 20505359
GO:0000046 NOT autophagic vacuole fusion IMP 20505359
GO:0000422 mitochondrion degradation IBA --
GO:0006497 protein lipidation IBA --
GO:0006995 cellular response to nitrogen starvation IBA --
genes like me logo Genes that share ontologies with WIPI2: view

No data available for Pathways by source for WIPI2 Gene

Transcripts for WIPI2 Gene

Unigene Clusters for WIPI2 Gene

WD repeat domain, phosphoinositide interacting 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WIPI2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - -
SP8: - - -
SP9: -
SP10:

Relevant External Links for WIPI2 Gene

GeneLoc Exon Structure for
WIPI2
ECgene alternative splicing isoforms for
WIPI2

Expression for WIPI2 Gene

mRNA expression in normal human tissues for WIPI2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WIPI2 Gene

SOURCE GeneReport for Unigene cluster for WIPI2 Gene Hs.122363

mRNA Expression by UniProt/SwissProt for WIPI2 Gene

Q9Y4P8-WIPI2_HUMAN
Tissue specificity: Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.
genes like me logo Genes that share expressions with WIPI2: view

Orthologs for WIPI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WIPI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WIPI2 36
  • 99.54 (n)
  • 100 (a)
WIPI2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WIPI2 36
  • 87.08 (n)
  • 94.04 (a)
WIPI2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WIPI2 36
  • 88.53 (n)
  • 95.64 (a)
WIPI2 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wipi2 36
  • 88.15 (n)
  • 97.02 (a)
Wipi2 16
Wipi2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WIPI2 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WIPI2 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wipi2 36
  • 87.16 (n)
  • 97.48 (a)
chicken
(Gallus gallus)
Aves WIPI2 36
  • 81.65 (n)
  • 94.95 (a)
WIPI2 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WIPI2 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53220 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497399 36
  • 74.9 (n)
  • 88.45 (a)
Str.10600 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14106 36
zebrafish
(Danio rerio)
Actinopterygii wipi2 37
  • 87 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005910 36
  • 64.61 (n)
  • 69.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atg18 36
  • 62.17 (n)
  • 64.52 (a)
Atg18 37
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atg-18 36
  • 51.42 (n)
  • 44.32 (a)
atg-18 37
  • 40 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL119W 36
  • 48.43 (n)
  • 39.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG18 36
  • 48.12 (n)
  • 39.71 (a)
ATG18 37
  • 26 (a)
OneToMany
ATG18 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04664g 36
  • 47.36 (n)
  • 39.1 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons G18B 36
  • 44.4 (n)
  • 38.06 (a)
rice
(Oryza sativa)
Liliopsida Os02g0791800 36
  • 44.84 (n)
  • 32.15 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03441 36
  • 52.79 (n)
  • 43.93 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atg18 36
  • 45.66 (n)
  • 42.63 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1716 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 58 (a)
ManyToMany
-- 37
  • 69 (a)
ManyToMany
Species with no ortholog for WIPI2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WIPI2 Gene

ENSEMBL:
Gene Tree for WIPI2 (if available)
TreeFam:
Gene Tree for WIPI2 (if available)

Paralogs for WIPI2 Gene

Paralogs for WIPI2 Gene

Selected SIMAP similar genes for WIPI2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for WIPI2 Gene

genes like me logo Genes that share paralogs with WIPI2: view

Variants for WIPI2 Gene

Sequence variations from dbSNP and Humsavar for WIPI2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7904 -- 5,233,490(-) TCATC(A/G)TCCTT utr-variant-3-prime
rs11715 -- 5,231,690(-) ACAAA(C/T)AAAAT utr-variant-3-prime
rs12472 -- 5,232,546(+) GATCC(C/T)GGTCA utr-variant-3-prime
rs1134489 -- 5,217,942(+) ATTCC(A/G)GCTCA synonymous-codon, reference
rs1134491 -- 5,227,288(+) AGAGC(C/T)TTCGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for WIPI2 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv887390 CNV Loss 21882294
nsv887391 CNV Loss 21882294
nsv823995 CNV Gain 20364138
nsv5627 CNV Insertion 18451855
nsv830889 CNV Loss 17160897
esv2498578 CNV Deletion 19546169
nsv8034 CNV Gain 18304495
nsv887392 CNV Loss 21882294

Relevant External Links for WIPI2 Gene

HapMap Linkage Disequilibrium report
WIPI2

Disorders for WIPI2 Gene

Relevant External Links for WIPI2

Genetic Association Database (GAD)
WIPI2
genes like me logo Genes that share disorders with WIPI2: view

No data available for UniProtKB/Swiss-Prot for WIPI2 Gene

Publications for WIPI2 Gene

  1. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. (PMID: 15602573) Proikas-Cezanne T. … Nordheim A. (Oncogene 2004) 2 3 4
  2. Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. (PMID: 20505359) Polson H.E. … Tooze S.A. (Autophagy 2010) 3 4
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for WIPI2 Gene

Sources for WIPI2 Gene

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