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Aliases for WIPI1 Gene

Aliases for WIPI1 Gene

  • WD Repeat Domain, Phosphoinositide Interacting 1 2 3
  • WD40 Repeat Protein Interacting With Phosphoinositides Of 49 KDa 3 4
  • Atg18 Protein Homolog 3 4
  • WIPI 49 KDa 3 4
  • WIPI49 3 4
  • WD40 Repeat Protein Interacting With PhosphoInositides Of 49kDa 3
  • WIPI-1 Alpha 3
  • ATG18A 3
  • WIPI-1 4
  • ATG18 3

External Ids for WIPI1 Gene

Previous GeneCards Identifiers for WIPI1 Gene

  • GC17M063930
  • GC17M066417
  • GC17M061803

Summaries for WIPI1 Gene

Entrez Gene Summary for WIPI1 Gene

  • WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

GeneCards Summary for WIPI1 Gene

WIPI1 (WD Repeat Domain, Phosphoinositide Interacting 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Cellular Senescence. GO annotations related to this gene include receptor binding and estrogen receptor binding. An important paralog of this gene is WIPI2.

UniProtKB/Swiss-Prot for WIPI1 Gene

  • Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.

Gene Wiki entry for WIPI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIPI1 Gene

Genomics for WIPI1 Gene

Regulatory Elements for WIPI1 Gene

Genomic Location for WIPI1 Gene

Chromosome:
17
Start:
68,420,948 bp from pter
End:
68,457,513 bp from pter
Size:
36,566 bases
Orientation:
Minus strand

Genomic View for WIPI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WIPI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPI1 Gene

Proteins for WIPI1 Gene

  • Protein details for WIPI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MNZ9-WIPI1_HUMAN
    Recommended name:
    WD repeat domain phosphoinositide-interacting protein 1
    Protein Accession:
    Q5MNZ9
    Secondary Accessions:
    • Q8IXM5
    • Q9NWF8

    Protein attributes for WIPI1 Gene

    Size:
    446 amino acids
    Molecular mass:
    48673 Da
    Quaternary structure:
    • Interacts with androgen receptor (AR) and the estrogen receptors ESR1 and ESR2. Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes.

    Alternative splice isoforms for WIPI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WIPI1 Gene

Proteomics data for WIPI1 Gene at MOPED

Post-translational modifications for WIPI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WIPI1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WIPI1 (ATG18)

No data available for DME Specific Peptides for WIPI1 Gene

Domains & Families for WIPI1 Gene

Gene Families for WIPI1 Gene

Protein Domains for WIPI1 Gene

Suggested Antigen Peptide Sequences for WIPI1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5MNZ9

UniProtKB/Swiss-Prot:

WIPI1_HUMAN :
  • The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane. Association to the membrane can also occur through binding to phosphatidylinositol 3-monophosphate (PI3P).
  • Belongs to the WD repeat SVP1 family.
  • Contains 7 WD repeats.
Domain:
  • The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane. Association to the membrane can also occur through binding to phosphatidylinositol 3-monophosphate (PI3P).
Family:
  • Belongs to the WD repeat SVP1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WIPI1: view

Function for WIPI1 Gene

Molecular function for WIPI1 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.

Gene Ontology (GO) - Molecular Function for WIPI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IDA 15602573
GO:0005515 protein binding --
GO:0030331 estrogen receptor binding IDA 15602573
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 15020712
GO:0050681 androgen receptor binding IDA 15602573
genes like me logo Genes that share ontologies with WIPI1: view
genes like me logo Genes that share phenotypes with WIPI1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WIPI1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WIPI1 Gene

Localization for WIPI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPI1 Gene

Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WIPI1 Gene COMPARTMENTS Subcellular localization image for WIPI1 gene
Compartment Confidence
cytoskeleton 5
endosome 5
golgi apparatus 5
vacuole 5
cytosol 3
lysosome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for WIPI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0000407 pre-autophagosomal structure IDA 15602573
GO:0000421 autophagosome membrane IDA 17618624
GO:0005737 cytoplasm IDA 17618624
GO:0005802 trans-Golgi network IDA 15020712
genes like me logo Genes that share ontologies with WIPI1: view

Pathways & Interactions for WIPI1 Gene

genes like me logo Genes that share pathways with WIPI1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for WIPI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 mitophagy IBA --
GO:0006497 protein lipidation IBA --
GO:0006914 autophagy IEP 15602573
GO:0006995 cellular response to nitrogen starvation IBA --
genes like me logo Genes that share ontologies with WIPI1: view

No data available for SIGNOR curated interactions for WIPI1 Gene

Drugs & Compounds for WIPI1 Gene

(1) Additional Compounds for WIPI1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Mannose 6-phosphate
  • alpha-D-Mannose-6-P
  • alpha-D-Mannose-6-phosphate
  • alpha-delta-Mannose-6-P
  • alpha-delta-Mannose-6-phosphate
  • D-Mannose 6-phosphate
3672-15-9
genes like me logo Genes that share compounds with WIPI1: view

Transcripts for WIPI1 Gene

Unigene Clusters for WIPI1 Gene

WD repeat domain, phosphoinositide interacting 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WIPI1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WIPI1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: -
SP2:
SP3: - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for WIPI1 Gene

GeneLoc Exon Structure for
WIPI1
ECgene alternative splicing isoforms for
WIPI1

Expression for WIPI1 Gene

mRNA expression in normal human tissues for WIPI1 Gene

mRNA differential expression in normal tissues according to GTEx for WIPI1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for WIPI1 Gene

This gene is overexpressed in Placenta (15.0), Skin (9.8), Salivary gland (9.0), and Heart (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WIPI1 Gene



SOURCE GeneReport for Unigene cluster for WIPI1 Gene Hs.463964

mRNA Expression by UniProt/SwissProt for WIPI1 Gene

Q5MNZ9-WIPI1_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues.
genes like me logo Genes that share expression patterns with WIPI1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for WIPI1 Gene

Orthologs for WIPI1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WIPI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WIPI1 35
  • 83.71 (n)
  • 89.46 (a)
MGC159964 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WIPI1 35
  • 89.61 (n)
  • 93.72 (a)
WIPI1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wipi1 35
  • 87.44 (n)
  • 94.39 (a)
Wipi1 16
Wipi1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WIPI1 35
  • 99.4 (n)
  • 99.78 (a)
WIPI1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wipi1 35
  • 87.22 (n)
  • 93.95 (a)
oppossum
(Monodelphis domestica)
Mammalia WIPI1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves WIPI1 35
  • 80.05 (n)
  • 86.46 (a)
WIPI1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WIPI1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wipi1 35
  • 71.65 (n)
  • 77.91 (a)
zebrafish
(Danio rerio)
Actinopterygii wipi1 35
  • 68.4 (n)
  • 71.04 (a)
zgc64205 35
wipi1 36
  • 67 (a)
OneToMany
WIPI1 (1 of 2) 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Atg18 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atg-18 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG18 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
Species with no ortholog for WIPI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WIPI1 Gene

ENSEMBL:
Gene Tree for WIPI1 (if available)
TreeFam:
Gene Tree for WIPI1 (if available)

Paralogs for WIPI1 Gene

Paralogs for WIPI1 Gene

(3) SIMAP similar genes for WIPI1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with WIPI1: view

Variants for WIPI1 Gene

Sequence variations from dbSNP and Humsavar for WIPI1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_024848 -
VAR_053439 -

Structural Variations from Database of Genomic Variants (DGV) for WIPI1 Gene

Variant ID Type Subtype PubMed ID
nsv833523 CNV Gain 17160897
esv2557973 CNV Insertion 19546169
esv993931 CNV Insertion 20482838
esv1105165 CNV Insertion 17803354

Variation tolerance for WIPI1 Gene

Residual Variation Intolerance Score: 38.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WIPI1 Gene

HapMap Linkage Disequilibrium report
WIPI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIPI1 Gene

Disorders for WIPI1 Gene

Relevant External Links for WIPI1

Genetic Association Database (GAD)
WIPI1
Human Genome Epidemiology (HuGE) Navigator
WIPI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WIPI1
genes like me logo Genes that share disorders with WIPI1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WIPI1 Gene

Publications for WIPI1 Gene

  1. PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. (PMID: 15020712) Jeffries T.R. … Parker P.J. (Mol. Biol. Cell 2004) 2 23 67
  2. AMPK-independent induction of autophagy by cytosolic Ca2+ increase. (PMID: 20114074) Grotemeier A. … Stork B. (Cell. Signal. 2010) 23 67
  3. Assessing mammalian autophagy by WIPI-1/Atg18 puncta formation. (PMID: 19200887) Proikas-Cezanne T. … Pfisterer S.G. (Meth. Enzymol. 2009) 23 67
  4. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. (PMID: 15602573) Proikas-Cezanne T. … Nordheim A. (Oncogene 2004) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for WIPI1 Gene

Sources for WIPI1 Gene

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