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Aliases for WIPF3 Gene

Aliases for WIPF3 Gene

  • WAS/WASL Interacting Protein Family, Member 3 2 3
  • CR16 3 4 6
  • Corticosteroids And Regional Expression Protein 16 Homolog 3 4
  • WAS/WASL-Interacting Protein Family Member 3 3

External Ids for WIPF3 Gene

Summaries for WIPF3 Gene

GeneCards Summary for WIPF3 Gene

WIPF3 (WAS/WASL Interacting Protein Family, Member 3) is a Protein Coding gene. Among its related pathways are Fcgamma receptor (FCGR) dependent phagocytosis and Fcgamma receptor (FCGR) dependent phagocytosis. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot for WIPF3 Gene

  • May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIPF3 Gene

Genomics for WIPF3 Gene

Regulatory Elements for WIPF3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WIPF3 Gene

Start:
29,806,486 bp from pter
End:
29,917,066 bp from pter
Size:
110,581 bases
Orientation:
Plus strand

Genomic View for WIPF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WIPF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPF3 Gene

Proteins for WIPF3 Gene

  • Protein details for WIPF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGB9-WIPF3_HUMAN
    Recommended name:
    WAS/WASL-interacting protein family member 3
    Protein Accession:
    A6NGB9
    Secondary Accessions:
    • B8ZZV2

    Protein attributes for WIPF3 Gene

    Size:
    483 amino acids
    Molecular mass:
    49458 Da
    Quaternary structure:
    • Interacts with WASL, and monomeric and filamentous actin.

neXtProt entry for WIPF3 Gene

Proteomics data for WIPF3 Gene at MOPED

Post-translational modifications for WIPF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WIPF3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WIPF3 Gene

Domains for WIPF3 Gene

Protein Domains for WIPF3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WIPF3 Gene

Graphical View of Domain Structure for InterPro Entry

A6NGB9

UniProtKB/Swiss-Prot:

WIPF3_HUMAN :
  • A6NGB9
Domain:
  • The WH2 domain is found in a number of putative actin-binding proteins.
  • The profilin-binding motif has been implicated in the interaction with profilin and SH3 domains.
  • The KLKR motif is essential for G-actin binding and for actin polymerization.
  • Contains 1 WH2 domain.
Family:
  • Belongs to the verprolin family.
genes like me logo Genes that share domains with WIPF3: view

No data available for Gene Families for WIPF3 Gene

Function for WIPF3 Gene

Molecular function for WIPF3 Gene

UniProtKB/Swiss-Prot Function:
May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for WIPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with WIPF3: view

Phenotypes for WIPF3 Gene

genes like me logo Genes that share phenotypes with WIPF3: view

Animal Models for WIPF3 Gene

MGI Knock Outs for WIPF3:

Animal Model Products

CRISPR Products

miRNA for WIPF3 Gene

miRTarBase miRNAs that target WIPF3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WIPF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WIPF3 Gene

Localization for WIPF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPF3 Gene

Cytoplasm. Note=In hippocampal neurons colocalizes with WASL in the cell body, axons and the growth cone. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WIPF3 Gene COMPARTMENTS Subcellular localization image for WIPF3 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for WIPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with WIPF3: view

Pathways for WIPF3 Gene

genes like me logo Genes that share pathways with WIPF3: view

Pathways by source for WIPF3 Gene

Interacting Proteins for WIPF3 Gene

Gene Ontology (GO) - Biological Process for WIPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with WIPF3: view

Transcripts for WIPF3 Gene

mRNA/cDNA for WIPF3 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WIPF3 Gene

WAS/WASL interacting protein family, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WIPF3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WIPF3 Gene

No ASD Table

Relevant External Links for WIPF3 Gene

GeneLoc Exon Structure for
WIPF3
ECgene alternative splicing isoforms for
WIPF3

Expression for WIPF3 Gene

mRNA expression in normal human tissues for WIPF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WIPF3 Gene

This gene is overexpressed in Ovary (6.2), Brain - Hippocampus (4.6), Brain - Putamen (basal ganglia) (4.2), and Brain - Nucleus accumbens (basal ganglia) (4.0).

Protein differential expression in normal tissues for WIPF3 Gene

This gene is overexpressed in Testis (34.2), Frontal cortex (10.8), Ovary (10.3), and Fetal ovary (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WIPF3 Gene

SOURCE GeneReport for Unigene cluster for WIPF3 Gene Hs.380698

genes like me logo Genes that share expressions with WIPF3: view

Expression partners for WIPF3 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for WIPF3 Gene

Orthologs for WIPF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WIPF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WIPF3 35
  • 82.41 (n)
  • 84.19 (a)
WIPF3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WIPF3 35
  • 85.6 (n)
  • 86.73 (a)
WIPF3 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wipf3 35
  • 81.24 (n)
  • 81.4 (a)
Wipf3 16
Wipf3 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WIPF3 35
  • 99.45 (n)
  • 99.59 (a)
WIPF3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wipf3 35
  • 78.86 (n)
  • 81.2 (a)
oppossum
(Monodelphis domestica)
Mammalia WIPF3 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves WIPF3 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WIPF3 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii WIPF3 36
  • 33 (a)
OneToOne
Species with no ortholog for WIPF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WIPF3 Gene

ENSEMBL:
Gene Tree for WIPF3 (if available)
TreeFam:
Gene Tree for WIPF3 (if available)

Paralogs for WIPF3 Gene

No data available for Paralogs for WIPF3 Gene

Variants for WIPF3 Gene

Sequence variations from dbSNP and Humsavar for WIPF3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs116673 -- 29,835,211(-) AATCT(A/C)TCATT intron-variant
rs174909 -- 29,804,704(+) AGCTT(G/T)AGCAC upstream-variant-2KB
rs174910 -- 29,805,990(+) ACGTC(A/G)GCTCC upstream-variant-2KB
rs174911 -- 29,806,277(+) CCGCC(C/G)GCGCA upstream-variant-2KB
rs174912 -- 29,806,723(+) GTGGA(A/G)GGAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WIPF3 Gene

Variant ID Type Subtype PubMed ID
dgv2073e1 CNV Complex 17122850
nsv887900 CNV Loss 21882294
nsv830936 CNV Gain 17160897
nsv5682 CNV Insertion 18451855
esv2734190 CNV Deletion 23290073
esv2734191 CNV Deletion 23290073
esv2734192 CNV Deletion 23290073
esv1527161 CNV Deletion 17803354
esv2734193 CNV Deletion 23290073
esv2676972 CNV Deletion 23128226

Relevant External Links for WIPF3 Gene

HapMap Linkage Disequilibrium report
WIPF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIPF3 Gene

Disorders for WIPF3 Gene

No disorders were found for WIPF3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for WIPF3 Gene

Publications for WIPF3 Gene

  1. The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs. (PMID: 12372256) Zettl M. … Way M. (Curr. Biol. 2002) 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. (PMID: 14506234) Salazar M.A. … De Camilli P. (J. Biol. Chem. 2003) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Male-specific sterility caused by the loss of CR16. (PMID: 17573773) Suetsugu S. … Takenawa T. (Genes Cells 2007) 3

Products for WIPF3 Gene

Sources for WIPF3 Gene

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