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Aliases for WIPF3 Gene

Aliases for WIPF3 Gene

  • WAS/WASL Interacting Protein Family Member 3 2 3 5
  • Corticosteroids And Regional Expression Protein 16 Homolog 3 4
  • WAS/WASL Interacting Protein Family, Member 3 2 3
  • CR16 3 4

External Ids for WIPF3 Gene

Summaries for WIPF3 Gene

GeneCards Summary for WIPF3 Gene

WIPF3 (WAS/WASL Interacting Protein Family Member 3) is a Protein Coding gene. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Signaling by Rho GTPases. GO annotations related to this gene include actin binding and SH3 domain binding.

UniProtKB/Swiss-Prot for WIPF3 Gene

  • May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIPF3 Gene

Genomics for WIPF3 Gene

Regulatory Elements for WIPF3 Gene

Enhancers for WIPF3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WIPF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for WIPF3 Gene

29,806,486 bp from pter
29,917,066 bp from pter
110,581 bases
Plus strand

Genomic View for WIPF3 Gene

Genes around WIPF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WIPF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WIPF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPF3 Gene

Proteins for WIPF3 Gene

  • Protein details for WIPF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAS/WASL-interacting protein family member 3
    Protein Accession:
    Secondary Accessions:
    • B8ZZV2

    Protein attributes for WIPF3 Gene

    483 amino acids
    Molecular mass:
    49458 Da
    Quaternary structure:
    • Interacts with WASL, and monomeric and filamentous actin.

neXtProt entry for WIPF3 Gene

Proteomics data for WIPF3 Gene at MOPED

Post-translational modifications for WIPF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WIPF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WIPF3 Gene

Domains & Families for WIPF3 Gene

Protein Domains for WIPF3 Gene


Suggested Antigen Peptide Sequences for WIPF3 Gene

Graphical View of Domain Structure for InterPro Entry



  • The WH2 domain is found in a number of putative actin-binding proteins.
  • Belongs to the verprolin family.
  • The WH2 domain is found in a number of putative actin-binding proteins.
  • The profilin-binding motif has been implicated in the interaction with profilin and SH3 domains.
  • The KLKR motif is essential for G-actin binding and for actin polymerization.
  • Contains 1 WH2 domain.
  • Belongs to the verprolin family.
genes like me logo Genes that share domains with WIPF3: view

No data available for Gene Families for WIPF3 Gene

Function for WIPF3 Gene

Molecular function for WIPF3 Gene

UniProtKB/Swiss-Prot Function:
May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for WIPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with WIPF3: view

Phenotypes for WIPF3 Gene

genes like me logo Genes that share phenotypes with WIPF3: view

Animal Models for WIPF3 Gene

MGI Knock Outs for WIPF3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WIPF3 Gene

Localization for WIPF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPF3 Gene

Cytoplasm. Note=In hippocampal neurons colocalizes with WASL in the cell body, axons and the growth cone. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for WIPF3 Gene COMPARTMENTS Subcellular localization image for WIPF3 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3
endoplasmic reticulum 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for WIPF3 Gene

Pathways & Interactions for WIPF3 Gene

genes like me logo Genes that share pathways with WIPF3: view

Interacting Proteins for WIPF3 Gene

Gene Ontology (GO) - Biological Process for WIPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000147 NOT actin cortical patch assembly IBA --
GO:0007275 multicellular organism development IEA --
GO:0008360 regulation of cell shape IBA --
GO:0030048 actin filament-based movement IBA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with WIPF3: view

No data available for SIGNOR curated interactions for WIPF3 Gene

Drugs & Compounds for WIPF3 Gene

No Compound Related Data Available

Transcripts for WIPF3 Gene

mRNA/cDNA for WIPF3 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WIPF3 Gene

WAS/WASL interacting protein family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WIPF3 Gene

No ASD Table

Relevant External Links for WIPF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WIPF3 Gene

mRNA expression in normal human tissues for WIPF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WIPF3 Gene

This gene is overexpressed in Ovary (x6.2), Brain - Hippocampus (x4.6), Brain - Putamen (basal ganglia) (x4.2), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for WIPF3 Gene

This gene is overexpressed in Testis (34.2), Frontal cortex (10.8), Ovary (10.3), and Fetal ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WIPF3 Gene

SOURCE GeneReport for Unigene cluster for WIPF3 Gene Hs.380698

genes like me logo Genes that share expression patterns with WIPF3: view

Protein tissue co-expression partners for WIPF3 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for WIPF3 Gene

Orthologs for WIPF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WIPF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WIPF3 35
  • 82.41 (n)
  • 84.19 (a)
WIPF3 36
  • 85 (a)
(Canis familiaris)
Mammalia WIPF3 35
  • 85.6 (n)
  • 86.73 (a)
WIPF3 36
  • 63 (a)
(Mus musculus)
Mammalia Wipf3 35
  • 81.24 (n)
  • 81.4 (a)
Wipf3 16
Wipf3 36
  • 78 (a)
(Pan troglodytes)
Mammalia WIPF3 35
  • 99.45 (n)
  • 99.59 (a)
WIPF3 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Wipf3 35
  • 78.86 (n)
  • 81.2 (a)
(Monodelphis domestica)
Mammalia WIPF3 36
  • 52 (a)
(Gallus gallus)
Aves WIPF3 36
  • 48 (a)
(Anolis carolinensis)
Reptilia WIPF3 36
  • 42 (a)
(Danio rerio)
Actinopterygii WIPF3 36
  • 33 (a)
Species with no ortholog for WIPF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WIPF3 Gene

Gene Tree for WIPF3 (if available)
Gene Tree for WIPF3 (if available)

Paralogs for WIPF3 Gene

No data available for Paralogs for WIPF3 Gene

Variants for WIPF3 Gene

Sequence variations from dbSNP and Humsavar for WIPF3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3750092 - 29,884,456(-) GAGTT(C/T)CACTG reference, missense
rs878900 -- 29,876,223(+) AAATT(A/T)TGATA intron-variant
rs878901 -- 29,876,401(+) GTCCC(C/T)GGCCC intron-variant
rs878902 -- 29,876,411(+) CTTGC(C/T)AACCC intron-variant
rs878903 -- 29,877,156(-) TATGC(A/T)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WIPF3 Gene

Variant ID Type Subtype PubMed ID
dgv2073e1 CNV Complex 17122850
nsv887900 CNV Loss 21882294
nsv830936 CNV Gain 17160897
nsv5682 CNV Insertion 18451855
esv2734190 CNV Deletion 23290073
esv2734191 CNV Deletion 23290073
esv2734192 CNV Deletion 23290073
esv1527161 CNV Deletion 17803354
esv2734193 CNV Deletion 23290073
esv2676972 CNV Deletion 23128226

Variation tolerance for WIPF3 Gene

Gene Damage Index Score: 3.55; 55.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WIPF3 Gene

Disorders for WIPF3 Gene

Relevant External Links for WIPF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WIPF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WIPF3 Gene

Publications for WIPF3 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genetic variants near PDGFRA are associated with corneal curvature in Australians. (PMID: 22969067) Mishra A. … Mackey D.A. (Invest. Ophthalmol. Vis. Sci. 2012) 3
  4. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PMID: 21706016) Bisson N. … Pawson T. (Nat. Biotechnol. 2011) 3
  5. [Expression of CR16 in the testis of patients with idiopathic azoospermia]. (PMID: 21348202) Wen Z.N. … Xiang W.P. (Zhonghua Nan Ke Xue 2010) 3

Products for WIPF3 Gene

Sources for WIPF3 Gene