WIPF3 Gene
protein-coding GIFtS : 43
GCID: GC07 P029842
WAS/WASL interacting protein family, member 3
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Aliasesfor WIPF3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases WAS/WASL Interacting Protein Family, Member 3 1 2 CR161 2 3 5 Corticosteroids And Regional Expression Protein 16 Homolog2 3 FLJ369311 WAS/WASL-Interacting Protein Family Member 32
Export aliases for WIPF3 gene to outside databases
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Summariesfor WIPF3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: WIPF3_HUMAN, A6NGB9 Function : May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity)
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Genomic Viewsfor WIPF3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the WIPF3 gene promoter: NF-1 Egr-1 RREB-1 POU3F1 Olf-1 C/EBPalpha MZF-1 Nkx6-1 HOXA5 Other transcription factors Search SABiosciences Chromatin IP Primers for WIPF3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat WIPF3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7p14.3 Ensembl cytogenetic band: 7p14.3 HGNC cytogenetic band: 7p15.1 WIPF3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P029842: view genomic region
(about GC identifiers )
Start:
29,846,102 bp from pter
End:
29,956,682 bp from pter
Size:
110,581 bases
Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 29,965,324-29,995,620
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Proteinsfor WIPF3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: WIPF3_HUMAN, A6NGB9 (See
protein sequence )Recommended Name: WAS/WASL-interacting protein family member 3 Size : 483 amino acids; 49348 Da
Subunit : Interacts with WASL, and monomeric and filamentous actin (By similarity)
Subcellular location : Cytoplasm. Note=In hippocampal neurons colocalizes with WASL in the cell body, axons and thegrowth cone (By similarity) Explore the universe of human proteins at neXtProt for WIPF3: NX_A6NGB9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_A6NGB9 WIPF3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001073998.2 ENSEMBL proteins: ENSP00000386790 ENSP00000386878 ENSP00000242140 Reactome Protein details: A6NGB9 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
WIPF3 for ontologies About GeneDecksing WIPF3 Antibody Products: Assay Products for WIPF3:
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Protein
Domains / Familiesfor WIPF3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
WIPF3 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry A6NGB9 ProtoNet protein and cluster: A6NGB9
UniProtKB/Swiss-Prot: WIPF3_HUMAN, A6NGB9 Domain : The WH2 domain is found in a number of putative actin-binding proteins (By similarity)Domain : The profilin-binding motif has been implicated in the interaction with profilin and SH3 domains (By similarity)Domain : The KLKR motif is essential for G-actin binding and for actin polymerization (By similarity)Similarity : Belongs to the verprolin familySimilarity : Contains 1 WH2 domain
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Functionfor WIPF3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: WIPF3_HUMAN, A6NGB9 Function : May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for WIPF3 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for WIPF3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: WIPF3 (NM_001080529 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WIPF3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WIPF3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF3
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003779 actin binding
IEA -- GO:0017124 SH3 domain binding
-- --
WIPF3 for ontologies About GeneDecksing Animal Models: Mouse knock-out Wipf3 tm1Tta for WIPF3 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Wipf3) :
WIPF3 for phenotypes About GeneDecksing
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Pathways & Interactionsfor WIPF3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Regulation of actin dynamics for phagocytic cup formation 2 Immune System
Pathway sources See GeneCards unified pathways Show all pathways 5/6
Reactome Pathways for WIPF3 (see all 6 )
WIPF3 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WIPF3 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)3 Interacting proteins for WIPF3 (ENSP00000386878 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007275 multicellular organismal development
IEA -- GO:0007283 spermatogenesis
IEA -- GO:0030154 cell differentiation
IEA --
WIPF3 for ontologies About GeneDecksing
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Drugs & Compoundsfor WIPF3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for WIPF3 Search CenterWatch for drugs/clinical trials and news about WIPF3
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Transcriptsfor WIPF3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for WIPF3 gene: NM_001080529.2 Unigene Cluster for WIPF3:
WAS/WASL interacting protein family, member 3 Hs.380698 [show with all ESTs ] Unigene Representative Sequence: NM_001080529 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000409123 (uc003taj.2 ) ENST00000409290 (uc022aaz.1 ) ENST00000242140 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for WIPF3 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for WIPF3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: WIPF3 (NM_001080529 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WIPF3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WIPF3
5 DOTS entries : DT.40191290 DT.310359
DT.99927508 DT.92416208 DT.309500 GeneLoc Exon Structure
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Expression for WIPF3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section WIPF3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCAGGCAACT
About this image WIPF3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See WIPF3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for WIPF3 SOURCE GeneReport for Unigene cluster: Hs.380698 SABiosciences Custom PCR Arrays for WIPF3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for WIPF3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat WIPF3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat WIPF3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat WIPF3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF3
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Orthologsfor WIPF3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for WIPF3 gene from 5/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for WIPF3 (if available)TreeFam Gene Tree for WIPF3 (if available)
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Paralogsfor WIPF3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for WIPF3 gene WIPF1 2 WIPF2 2
WIPF3 for paralogs About GeneDecksing
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Genomic Variantsfor WIPF3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for WIPF3 (29846102 - 29956682 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for WIPF3 1 CNV : 3673
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing WIPF3
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Disorders
/ Diseasesfor WIPF3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
WIPF3 for disorders About GeneDecksing
OMIM gene information: 612432
OMIM disorders : --6 diseases for WIPF3 : About MalaCards wiskott-aldrich syndrome paranasal sinus cancer sinusitis sinus cancer azoospermia neuronitis Export disorders for WIPF3 gene to outside databases
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Publicationsfor WIPF3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for WIPF3 gene integrated from 9 sources : (articles sorted by number of sources associating them with WIPF3) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence of human chromosome 7. (PubMed id 12853948) 1 , 2 Hillier L.W.... Wilson R.K. (2003) The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs. (PubMed id 12372256) 1 , 2 Zettl M. and Way M. (2002) [Expression of CR16 in the testis of patients with id iopathic azoospermia]. (PubMed id 21348202) 1 Wen Z.N....Xiang W.P. (2010) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) Male-specific sterility caused by the loss of CR16. (PubMed id 17573773) 1 Suetsugu S....Takenawa T. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. (PubMed id 14506234) 1 Salazar M.A.... De Camilli P. (2003) CR16 forms a complex with N-WASP in brain and is a no vel member of a conserved proline-rich actin-binding protein family. (PubMed id 11553796) 1 Ho H.Y....Kirschner M.W. (2001)
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External Searches for WIPF3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing WIPF3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing WIPF3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing WIPF3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for WIPF3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for WIPF3 gene: Search GeneIP for patents involving WIPF3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor WIPF3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for WIPF3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for WIPF3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for WIPF3 OriGene Protein Over-expression Lysate for WIPF3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for WIPF3 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for WIPF3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for WIPF3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for WIPF3 OriGene Custom Protein Services for WIPF3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WIPF3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing WIPF3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat WIPF3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat WIPF3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat WIPF3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat WIPF3
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WIPF3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF3
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WIPF3
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