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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WIPF3 Gene

protein-coding   GIFtS: 43
GCID: GC07P029842

WAS/WASL interacting protein family, member 3

 Explore 6 diseases affiliated with
WIPF3 via our new
 Human Malady Compendium 
Biological research products
for WIPF3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
WAS/WASL Interacting Protein Family, Member 31 2
CR161 2 3 5
Corticosteroids And Regional Expression Protein 16 Homolog2 3
FLJ369311
WAS/WASL-Interacting Protein Family Member 32

External Ids:    HGNC: 220041   Entrez Gene: 6441502   Ensembl: ENSG000001225747   OMIM: 6124325   UniProtKB: A6NGB93   

Export aliases for WIPF3 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: WIPF3_HUMAN, A6NGB9
Function: May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WIPF3 gene promoter:
         NF-1   Egr-1   RREB-1   POU3F1   Olf-1   C/EBPalpha   MZF-1   Nkx6-1   HOXA5   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for WIPF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WIPF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p15.1

WIPF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WIPF3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P029842:  view genomic region     (about GC identifiers)

Start:
29,846,102 bp from pter      End:
29,956,682 bp from pter
Size:
110,581 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 29,965,324-29,995,620     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WIPF3_HUMAN, A6NGB9 (See protein sequence)
Recommended Name: WAS/WASL-interacting protein family member 3  
Size: 483 amino acids; 49348 Da
Subunit: Interacts with WASL, and monomeric and filamentous actin (By similarity)
Subcellular location: Cytoplasm. Note=In hippocampal neurons colocalizes with WASL in the cell body, axons and the
growth cone (By similarity)

Explore the universe of human proteins at neXtProt for WIPF3: NX_A6NGB9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NGB9

  • WIPF3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001073998.2  
    ENSEMBL proteins: 
     ENSP00000386790   ENSP00000386878   ENSP00000242140  
    Reactome Protein details: A6NGB9
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: WIPF3
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    Novus Biologicals WIPF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WIPF3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--


    WIPF3 for ontologies           About GeneDecksing



    WIPF3 Antibody Products: 
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    Uscn Antibodies for WIPF3
    Search ThermoFisher Antibodies for WIPF3

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    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for WIPF3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    WIPF3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry A6NGB9

    ProtoNet protein and cluster: A6NGB9

    UniProtKB/Swiss-Prot: WIPF3_HUMAN, A6NGB9
    Domain: The WH2 domain is found in a number of putative actin-binding proteins (By similarity)
    Domain: The profilin-binding motif has been implicated in the interaction with profilin and SH3 domains (By similarity)
    Domain: The KLKR motif is essential for G-actin binding and for actin polymerization (By similarity)
    Similarity: Belongs to the verprolin family
    Similarity: Contains 1 WH2 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: WIPF3_HUMAN, A6NGB9
    Function: May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WIPF3
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate WIPF3 (see all 55):
    hsa-miR-3607-3p hsa-miR-3194-5p hsa-miR-30d hsa-miR-3653 hsa-miR-3921 hsa-miR-30a hsa-miR-124 hsa-miR-629*
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0017124SH3 domain binding ----


    WIPF3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Wipf3tm1Tta for WIPF3
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Wipf3):
     homeostasis/metabolism  reproductive system 

    WIPF3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of actin dynamics for phagocytic cup formation
    Regulation of actin dynamics for phagocytic cup formation1.00
    Fcgamma receptor (FCGR) dependent phagocytosis0.80
    Role of myosins in phagosome formation0.80
    Branching and elongation of mother and daughter filaments0.29
    2Immune System
    Immune System1.00
    Innate Immune System0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for WIPF3 (see all 6)
        Role of myosins in phagosome formation
    Branching and elongation of mother and daughter filaments
    Regulation of actin dynamics for phagocytic cup formation
    Fcgamma receptor (FCGR) dependent phagocytosis
    Immune System



    WIPF3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WIPF3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for WIPF3 (ENSP000003868784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNMBPENSP000003156594STRING: ENSP00000315659
    VSTM2LENSP000003625604STRING: ENSP00000362560
    GRB2ENSP000003390074STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--


    WIPF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WIPF3
    Search CenterWatch for drugs/clinical trials and news about WIPF3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WIPF3 gene: 
    NM_001080529.2  

    Unigene Cluster for WIPF3:

    WAS/WASL interacting protein family, member 3
    Hs.380698  [show with all ESTs]
    Unigene Representative Sequence: NM_001080529
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409123(uc003taj.2) ENST00000409290(uc022aaz.1) ENST00000242140


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WIPF3
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate WIPF3 (see all 55):
    hsa-miR-3607-3p hsa-miR-3194-5p hsa-miR-30d hsa-miR-3653 hsa-miR-3921 hsa-miR-30a hsa-miR-124 hsa-miR-629*
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    Inhib. RNA
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    5 DOTS entries:

    DT.40191290  DT.310359  DT.99927508  DT.92416208  DT.309500 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WIPF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGGCAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    WIPF3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WIPF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WIPF3

    SOURCE GeneReport for Unigene cluster: Hs.380698
        SABiosciences Custom PCR Arrays for WIPF3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WIPF3 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves WIPF31 WAS/WASL interacting protein family, member 3 61.25(n)
    60.68(a)
      420634  XM_418733.3  XP_418733.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    17(a)
    1 ↔ 1
    2(191672199-191676371)
    zebrafish
    (Danio rerio)
    Actinopterygii sb:cb6491 sb:cb649 52.82(n)
    49.03(a)
      368364  XM_002665520.2  XP_002665566.2 
    worm
    (Caenorhabditis elegans)
    Secernentea wip-11 Protein WIP-1 43.6(n)
    39.74(a)
      175681  NM_171109.2  NP_741122.2 
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    retrotransposon protein, putative, unclassified
    retrotransposon protein, putative, unclassified, e...
    (see all 3)
    19(a)
    15(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    9(8065658-8066308)
    4(20536076-20537874)


    ENSEMBL Gene Tree for WIPF3 (if available)
    TreeFam Gene Tree for WIPF3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WIPF3 gene
    WIPF12  WIPF22  

    WIPF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1854 NCBI SNPs in WIPF3 are shown (see all 1854    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1418128891,2
    --29844194(+) ACTGGC/GTCATG 1 -- us2k10--------
    rs1898792731,2
    --29844196(+) TGGCTC/TATGCT 1 -- us2k10--------
    rs1140745041,2
    F,--29844212(+) TGCTCA/CGGAGA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1832130521,2
    --29844244(+) CCATGA/GCAATG 1 -- us2k10--------
    rs1879603941,2
    --29844293(+) AGAATA/TCTAGT 1 -- us2k10--------
    rs1749091,2
    C,F,A,H,--29844320(+) AGCTTG/TAGCAC 1 -- us2k125Minor allele frequency- T:0.21NS EA NA WA CSA 2331
    rs1151465581,2
    F,--29844417(+) GGGCTT/AATGAA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1928738421,2
    --29844475(+) ATTATA/GATTCT 1 -- us2k10--------
    rs1462456471,2
    --29844556(+) CTACAC/TATAGA 1 -- us2k10--------
    rs7134931,2
    C,F,A,H,--29844708(-) GTTCCT/CCAAGC 1 -- us2k130Minor allele frequency- C:0.48NS EA NA CSA WA 2959

    HapMap Linkage Disequilibrium report for WIPF3 (29846102 - 29956682 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for WIPF3
         1 CNV: 3673

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    WIPF3 for disorders           About GeneDecksing

    OMIM gene information: 612432    OMIM disorders: --

    6 diseases for WIPF3:    About MalaCards
    wiskott-aldrich syndrome    paranasal sinus cancer    sinusitis    sinus cancer
    azoospermia    neuronitis


    Export disorders for WIPF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WIPF3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with WIPF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    2. The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs. (PubMed id 12372256)1, 2 Zettl M. and Way M. (2002)
    3. [Expression of CR16 in the testis of patients with id iopathic azoospermia]. (PubMed id 21348202)1 Wen Z.N....Xiang W.P. (2010)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. Male-specific sterility caused by the loss of CR16. (PubMed id 17573773)1 Suetsugu S....Takenawa T. (2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. (PubMed id 14506234)1 Salazar M.A.... De Camilli P. (2003)
    8. CR16 forms a complex with N-WASP in brain and is a no vel member of a conserved proline-rich actin-binding protein family. (PubMed id 11553796)1 Ho H.Y....Kirschner M.W. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 644150 HGNC: 22004 Ensembl:ENSG00000122574 euGenes: HUgn644150 ECgene: WIPF3
    H-InvDB: WIPF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WIPF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WIPF3 gene:
    Search GeneIP for patents involving WIPF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
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