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Aliases for WIPF2 Gene

Aliases for WIPF2 Gene

  • WAS/WASL Interacting Protein Family, Member 2 2 3
  • WICH 3 4 6
  • WIRE 3 4 6
  • WASP-Interacting Protein-Related Protein 3 4
  • WIP- And CR16-Homologous Protein 3 4
  • WIP-Related Protein 3 4
  • WAS/WASL-Interacting Protein Family Member 2 3
  • WASP-Binding Protein 3

External Ids for WIPF2 Gene

Previous GeneCards Identifiers for WIPF2 Gene

  • GC17P035630
  • GC17P038375
  • GC17P034168

Summaries for WIPF2 Gene

Entrez Gene Summary for WIPF2 Gene

  • This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]

GeneCards Summary for WIPF2 Gene

WIPF2 (WAS/WASL Interacting Protein Family, Member 2) is a Protein Coding gene. Diseases associated with WIPF2 include laryngeal tuberculosis and peripheral retinal degeneration. Among its related pathways are Fcgamma receptor (FCGR) dependent phagocytosis and Cell adhesion Integrin-mediated cell adhesion and migration. GO annotations related to this gene include actin binding. An important paralog of this gene is WIPF1.

UniProtKB/Swiss-Prot for WIPF2 Gene

  • Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.

Gene Wiki entry for WIPF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIPF2 Gene

Genomics for WIPF2 Gene

Regulatory Elements for WIPF2 Gene

Genomic Location for WIPF2 Gene

Start:
40,219,304 bp from pter
End:
40,284,136 bp from pter
Size:
64,833 bases
Orientation:
Plus strand

Genomic View for WIPF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WIPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPF2 Gene

Proteins for WIPF2 Gene

  • Protein details for WIPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF74-WIPF2_HUMAN
    Recommended name:
    WAS/WASL-interacting protein family member 2
    Protein Accession:
    Q8TF74
    Secondary Accessions:
    • A8K0L3
    • Q658J8
    • Q71RE1
    • Q8TE44

    Protein attributes for WIPF2 Gene

    Size:
    440 amino acids
    Molecular mass:
    46289 Da
    Quaternary structure:
    • Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions. No interaction was seen with WASF2 and WASF3.
    Miscellaneous:
    • Access to the profilin-binding site is masked in the full-length protein
    SequenceCaution:
    • Sequence=AAQ15232.1; Type=Frameshift; Positions=373; Evidence={ECO:0000305};

    Alternative splice isoforms for WIPF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WIPF2 Gene

Proteomics data for WIPF2 Gene at MOPED

Post-translational modifications for WIPF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WIPF2 Gene

No data available for DME Specific Peptides for WIPF2 Gene

Domains for WIPF2 Gene

Protein Domains for WIPF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for WIPF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF74

UniProtKB/Swiss-Prot:

WIPF2_HUMAN :
  • Q8TF74
Domain:
  • Contains 1 WH2 domain.
Family:
  • Belongs to the verprolin family.
genes like me logo Genes that share domains with WIPF2: view

No data available for Gene Families for WIPF2 Gene

Function for WIPF2 Gene

Molecular function for WIPF2 Gene

UniProtKB/Swiss-Prot Function: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.

Gene Ontology (GO) - Molecular Function for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 20936779
genes like me logo Genes that share ontologies with WIPF2: view

miRNA for WIPF2 Gene

miRTarBase miRNAs that target WIPF2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WIPF2 Gene

Localization for WIPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPF2 Gene

Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WIPF2 Gene COMPARTMENTS Subcellular localization image for WIPF2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with WIPF2: view

Pathways for WIPF2 Gene

genes like me logo Genes that share pathways with WIPF2: view

Gene Ontology (GO) - Biological Process for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with WIPF2: view

Transcripts for WIPF2 Gene

Unigene Clusters for WIPF2 Gene

WAS/WASL interacting protein family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WIPF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - - - -
SP5: -
SP6: - - - - - - -
SP7: - -

Relevant External Links for WIPF2 Gene

GeneLoc Exon Structure for
WIPF2
ECgene alternative splicing isoforms for
WIPF2

Expression for WIPF2 Gene

mRNA expression in normal human tissues for WIPF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WIPF2 Gene

SOURCE GeneReport for Unigene cluster for WIPF2 Gene Hs.421622

mRNA Expression by UniProt/SwissProt for WIPF2 Gene

Q8TF74-WIPF2_HUMAN
Tissue specificity: Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta.
genes like me logo Genes that share expressions with WIPF2: view

No data available for mRNA differential expression in normal tissues for WIPF2 Gene

Orthologs for WIPF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WIPF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WIPF2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WIPF2 35
  • 91.4 (n)
  • 93.72 (a)
WIPF2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WIPF2 35
  • 93.81 (n)
  • 97.22 (a)
WIPF2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wipf2 35
  • 89.4 (n)
  • 93.74 (a)
Wipf2 16
Wipf2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WIPF2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WIPF2 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wipf2 35
  • 88.01 (n)
  • 93.74 (a)
chicken
(Gallus gallus)
Aves WIPF2 35
  • 74.76 (n)
  • 84.76 (a)
WIPF2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WIPF2 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69127 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4454 35
wipf2 35
  • 66.5 (n)
  • 73.3 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12755 35
WIPF2 (2 of 2) 36
  • 52 (a)
OneToMany
wipf2b 35
  • 63.11 (n)
  • 68.93 (a)
wipf2b 36
  • 66 (a)
OneToMany
Species with no ortholog for WIPF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WIPF2 Gene

ENSEMBL:
Gene Tree for WIPF2 (if available)
TreeFam:
Gene Tree for WIPF2 (if available)

Paralogs for WIPF2 Gene

Paralogs for WIPF2 Gene

Selected SIMAP similar genes for WIPF2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WIPF2: view

Variants for WIPF2 Gene

Sequence variations from dbSNP and Humsavar for WIPF2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12391 -- 40,282,549(-) TAATC(A/T)GAATA downstream-variant-500B, utr-variant-3-prime
rs12974 -- 40,282,550(-) GTAAT(C/T)AGAAT downstream-variant-500B, utr-variant-3-prime
rs15573 -- 40,282,584(-) GAAAA(A/T)ATCAA downstream-variant-500B, utr-variant-3-prime
rs1807273 -- 40,283,055(+) ATGGC(A/G)CATGC downstream-variant-500B
rs2304946 -- 40,282,483(-) GCAGA(C/G)AGATG downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WIPF2 Gene

Variant ID Type Subtype PubMed ID
nsv833444 CNV Loss 17160897
nsv525796 CNV Gain 19592680
esv2430508 CNV Deletion 19546169
esv2372222 CNV Deletion 18987734
esv2715907 CNV Deletion 23290073
esv2668303 CNV Deletion 23128226
dgv179n21 CNV Loss 19592680
esv2676976 CNV Deletion 23128226

Relevant External Links for WIPF2 Gene

HapMap Linkage Disequilibrium report
WIPF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIPF2 Gene

Disorders for WIPF2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for WIPF2 Gene including...

Search for WIPF2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for WIPF2 Gene

genes like me logo Genes that share disorders with WIPF2: view

No data available for UniProtKB/Swiss-Prot for WIPF2 Gene

Publications for WIPF2 Gene

  1. WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. (PMID: 11829459) Kato M. … Takenawa T. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 23
  2. The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. (PMID: 12213210) Aspenstroem P. (Exp. Cell Res. 2002) 2 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for WIPF2 Gene

Sources for WIPF2 Gene

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