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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WIPF2 Gene

protein-coding   GIFtS: 57
GCID: GC17P038375

WAS/WASL Interacting Protein Family, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WAS/WASL Interacting Protein Family, Member 21 2     WIP- And CR16-Homologous Protein2 3
WICH2 3 5     WIP-Related Protein2 3
WIRE2 3 5     WAS/WASL-Interacting Protein Family Member 22
WASP-Interacting Protein-Related Protein2 3     WASP-Binding Protein2

External Ids:    HGNC: 309231   Entrez Gene: 1471792   Ensembl: ENSG000001714757   OMIM: 6096925   UniProtKB: Q8TF743   

Export aliases for WIPF2 gene to outside databases

Previous GC identifers: GC17P035630 GC17P034168


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WIPF2 Gene:
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role
in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the
activated platelet-derived growth factor receptor and the actin polymerization machinery. (provided by RefSeq,
Jul 2008)

GeneCards Summary for WIPF2 Gene: 
WIPF2 (WAS/WASL interacting protein family, member 2) is a protein-coding gene. Diseases associated with WIPF2 include laryngeal tuberculosis, and olecranon bursitis, and among its related super-pathways are Regulation of actin dynamics for phagocytic cup formation and Immune System. GO annotations related to this gene include protein binding and actin binding. An important paralog of this gene is WIPF3.

UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74
Function: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB
receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate
with WASP and WASL to induce mobilization and reorganization of the actin filament system

Gene Wiki entry for WIPF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WIPF2 gene promoter:
         AhR   Sox5   NF-1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   NF-kappaB   Arnt   MZF-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWIPF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for WIPF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WIPF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.1   HGNC cytogenetic band: 17q21.2

WIPF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WIPF2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P038375:  view genomic region     (about GC identifiers)

Start:
38,375,556 bp from pter      End:
38,440,388 bp from pter
Size:
64,833 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74 (See protein sequence)
Recommended Name: WAS/WASL-interacting protein family member 2  
Size: 440 amino acids; 46289 Da
Subunit: Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two
proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions. No
interaction was seen with WASF2 and WASF3
Subcellular location: Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments
Miscellaneous: Access to the profilin-binding site is masked in the full-length protein
Sequence caution: Sequence=AAQ15232.1; Type=Frameshift; Positions=373;
Secondary accessions: A8K0L3 Q658J8 Q71RE1 Q8TE44
Alternative splicing: 2 isoforms:  Q8TF74-1   Q8TF74-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WIPF2: NX_Q8TF74

Explore proteomics data for WIPF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TF74

  • WIPF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WIPF2 Protein Expression
    REFSEQ proteins: NP_573571.1  
    ENSEMBL proteins: 
     ENSP00000462386   ENSP00000320924   ENSP00000463869   ENSP00000462826   ENSP00000377663  
     ENSP00000462350   ENSP00000463149   ENSP00000439175  
    Reactome Protein details: Q8TF74
    Human Recombinant Protein Products for WIPF2: 
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    Cloud-Clone Corp. Proteins for WIPF2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--

    WIPF2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry Q8TF74

    ProtoNet protein and cluster: Q8TF74

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74
    Similarity: Belongs to the verprolin family
    Similarity: Contains 1 WH2 domain


    WIPF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WIPF2_HUMAN, Q8TF74
    Function: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB
    receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate
    with WASP and WASL to induce mobilization and reorganization of the actin filament system

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--
         
    WIPF2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WIPF2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.80
    Fcgamma receptor (FCGR) dependent phagocytosis0.80
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3Cytoskeleton remodeling Reverse signaling by ephrin B
    Cytoskeleton remodeling Reverse signaling by ephrin B0.94
    4Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for WIPF2
        Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B


    2 GeneGo (Thomson Reuters) Pathways for WIPF2
        Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B

    4        Reactome Pathways for WIPF2
        Regulation of actin dynamics for phagocytic cup formation
    Fcgamma receptor (FCGR) dependent phagocytosis
    Immune System
    Innate Immune System



    WIPF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WIPF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/12 Interacting proteins for WIPF2 (Q8TF741, 2, 3 ENSP000003209244) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 3, ENSP000003390074EBI-2850112,EBI-401755 I2D: score=3 STRING: ENSP00000339007
    WWOXQ9NZC72, 3, ENSP000003861614MINT-72784 I2D: score=3 STRING: ENSP00000386161
    NCK2O436393, ENSP000002331544I2D: score=4 STRING: ENSP00000233154
    DNMBPQ6XZF73, ENSP000003156594I2D: score=3 STRING: ENSP00000315659
    WASP427683, ENSP000003658914I2D: score=3 STRING: ENSP00000365891
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030036actin cytoskeleton organization IEA--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    WIPF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WIPF2

    Search CenterWatch for drugs/clinical trials and news about WIPF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WIPF2 gene: 
    NM_133264.4  

    Unigene Clusters for WIPF2:

    WAS/WASL interacting protein family, member 2
    Hs.421622  [show with all ESTs], Hs.731598  [show with all ESTs]
    Unigene Representative Sequences: NM_133264, BC030561
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583268 ENST00000494757 ENST00000323571(uc002hug.1 uc002huh.1 uc010cww.1 uc002hui.1 uc010cwx.1 uc010cwy.1)
    ENST00000582781 ENST00000585043 ENST00000394103 ENST00000583130 ENST00000584296
    ENST00000578304(uc010cwv.1) ENST00000578623 ENST00000536600
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    Additional mRNA sequence: BC030561.1 

    18 DOTS entries:

    DT.95150088  DT.448673  DT.95369685  DT.100654097  DT.70104188  DT.100649406  DT.121001438  DT.97824892 
    DT.95290475  DT.100707218  DT.121001513  DT.121001444  DT.121001458  DT.95200423  DT.97847762  DT.121001461 
    DT.95092488  DT.95369684 

    24/386 AceView cDNA sequences (see all 386):

    W79928 AL044567 BU622152 AI268005 AI217937 AI279017 CN480645 BM719866 
    BU618338 AI077695 AW675087 BQ774047 BE551229 BE550068 AI680476 AF370396 
    AI088648 BM676731 AB043786 AI092765 BQ653754 BM052838 CB134940 N58620 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for WIPF2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:              -                       -                                                               
    SP2:                                      -     -     -     -     -     -                                 
    SP3:                                                                          -                           
    SP4:              -           -     -     -     -     -     -     -     -                                 
    SP5:              -                                                                                       


    ECgene alternative splicing isoforms for WIPF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WIPF2 expression in normal human tissues (normalized intensities)      WIPF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTTAATT
    WIPF2 Expression
    About this image


    WIPF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             medial temporal gyrus   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             salivary gland ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   

    See WIPF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WIPF2

    SOURCE GeneReport for Unigene clusters: Hs.421622 Hs.731598

    UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74
    Tissue specificity: Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed,
    with high expression in brain, kidney, lung, and placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WIPF2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wipf21 , 5 WAS/WASL interacting protein family, member 21, 5 89.47(n)1
    93.86(a)1
      11 (62.71 cM)5
    685241  NM_197940.21  NP_922922.11 
     988636385 
    chicken
    (Gallus gallus)
    Aves WIPF21 WAS/WASL interacting protein family, member 2 74.81(n)
    85.16(a)
      771898  XM_001235112.2  XP_001235113.2 
    lizard
    (Anolis carolinensis)
    Reptilia WIPF26
    --
    Uncharacterized protein
    82(a)
    6(a)
    1 ↔ 1
    possible ortholog
    6(69595881-69623222)
    GL343369.1(132837-134543)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691272 hypothetical protein MGC69127 76.38(n)    BC057751.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.127552 Danio rerio, clone IMAGE5413379, mRNA 72.9(n)    BC045975.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG137316
    CG137226
    (see all 6)
    --
    6(a)
    5(a)
    (see all 6)
    possible ortholog
    possible ortholog
    (see all 6)
    3L(17376736-17382056)
    3L(4485159-4490963)
    worm
    (Caenorhabditis elegans)
    Secernentea Y40B1A.36
    K08D12.66
    (see all 5)
    Protein K08D12.6
    (see all 5)
    8(a)
    7(a)
    (see all 5)
    possible ortholog
    many ↔ many
    (see all 5)
    I(13349410-13358674)
    IV(1720790-1723069)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VRP16
    Proline-rich actin-associated protein involved in ...
    6(a)
    1 → many
    XII(802653-805106)


    ENSEMBL Gene Tree for WIPF2 (if available)
    TreeFam Gene Tree for WIPF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WIPF2 gene
    WIPF32  
    1 SIMAP similar gene for WIPF2 using alignment to 5 protein entries:     WIPF2_HUMAN (see all proteins):
    WIPF1

    WIPF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1249 SNPs in WIPF2 are shown (see all 1249)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866478811,2
    --38373643(+) GGCCTC/TCCAAA 1 -- us2k10--------
    rs1914544971,2
    --38373655(+) TGCTGC/GGATTA 1 -- us2k10--------
    rs1178617591,2
    F--38373682(+) TGCCCG/CGTTAT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1848351891,2
    --38373849(+) ATATCA/TCTATT 1 -- us2k10--------
    rs1501832221,2
    C--38373907(+) CTTAT-/CACAGAG 1 -- us2k10--------
    rs1894488281,2
    --38373929(+) AGCATA/GGGGCT 1 -- us2k10--------
    rs1460075321,2
    C--38373932(+) ATGGGA/GCTTTA 1 -- us2k10--------
    rs1167674251,2
    F--38373987(+) TTGCAG/ATAAGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1814149951,2
    --38373992(+) GTAAGC/GCTTGA 1 -- us2k10--------
    rs1399096541,2
    --38374098(+) AATGTA/GGAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WIPF2 (38375556 - 38440388 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for WIPF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2668303CNV Deletion23128226
    esv2715907CNV Deletion23290073
    esv2430508CNV Deletion19546169
    esv2676976CNV Deletion23128226
    esv2372222CNV Deletion18987734
    dgv179n21CNV Loss19592680
    nsv833444CNV Loss17160897
    nsv525796CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609692    OMIM disorders: --

    11 diseases for WIPF2:    About MalaCards
    laryngeal tuberculosis    olecranon bursitis    hemopericardium    retinal perforation
    bursitis    peripheral retinal degeneration    retinal degeneration    wiskott-aldrich syndrome
    retinitis    laryngitis    tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for WIPF2:
    Laryngeal tuberculosis     Peripheral retinal degeneration

    WIPF2 for disorders           About GeneDecksing


    Export disorders for WIPF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WIPF2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with WIPF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. (PubMed id 12213210)1, 2, 3, 9 Aspenstroem P. (2002)
    2. WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. (PubMed id 11829459)1, 2, 3, 9 Kato M....Takenawa T. (2002)
    3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migr ation and invasion. (PubMed id 23295955)1 Lehtinen L....Iljin K. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 147179 HGNC: 30923 AceView: WIRE Ensembl:ENSG00000171475 euGenes: HUgn147179
    ECgene: WIPF2 H-InvDB: WIPF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WIPF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WIPF2 gene:
    Search GeneIP for patents involving WIPF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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