WIPF2 Gene
protein-coding GIFtS: 55
GCID: GC17P038375
|
|
WAS/WASL interacting protein family, member 2
| |
Aliases
for WIPF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WAS/WASL Interacting Protein Family, Member 21 2 | | WIP- And CR16-Homologous Protein2 3 | | WICH1 2 3 5 | | WIP-Related Protein2 3 | | WIRE1 2 3 5 | | WAS/WASL-Interacting Protein Family Member 22 | | WASP-Interacting Protein-Related Protein2 3 | | WASP-Binding Protein2 |
Export aliases for WIPF2 gene to outside databasesPrevious GC identifers: GC17P035630 GC17P034168 |
Summaries
for WIPF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WIPF2:
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role inthe WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between theactivated platelet-derived growth factor receptor and the actin polymerization machinery. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74Function: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors.Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASLto induce mobilization and reorganization of the actin filament system
Gene Wiki entry for WIPF2
|
Genomic Views
for WIPF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WIPF2 gene promoter:
AhR Sox5 NF-1 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 NF-kappaB Arnt MZF-1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WIPF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WIPF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.1 HGNC cytogenetic band: 17q21.2WIPF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P038375: view genomic region
(about GC identifiers)
Start:
|
38,375,556 bp from pter |
End:
|
38,440,388 bp from pter |
Size:
|
64,833 bases |
Orientation:
|
plus strand |
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Proteins
for WIPF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74 (See
protein sequence)Recommended Name: WAS/WASL-interacting protein family member 2 Size: 440 amino acids; 46289 Da
Subunit: Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteinsalong actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions. No interactionwas seen with WASF2 and WASF3
Subcellular location: Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments
Miscellaneous: Access to the profilin-binding site is masked in the full-length protein
Sequence caution: Sequence=AAQ15232.1; Type=Frameshift; Positions=373;
Secondary accessions: A8K0L3 Q658J8 Q71RE1 Q8TE44Alternative splicing: 2 isoforms: Q8TF74-1 Q8TF74-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WIPF2: NX_Q8TF74
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TF74
WIPF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_573571.1
ENSEMBL proteins: ENSP00000462386 ENSP00000463383 ENSP00000320924 ENSP00000463869 ENSP00000462826 ENSP00000377663 ENSP00000462350 ENSP00000463149 ENSP00000439175 Reactome Protein details: Q8TF74
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
WIPF2 for ontologies About GeneDecksing
WIPF2 Antibody Products:
Assay Products for WIPF2: |
Protein
Domains /
Families
for WIPF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WIPF2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TF74ProtoNet protein and cluster: Q8TF74 1 Blocks protein family: IPB003124 Actin-binding WH2
UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74Similarity: Belongs to the verprolin familySimilarity: Contains 1 WH2 domain |
Function
for WIPF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74Function: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors.Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASLto induce mobilization and reorganization of the actin filament system
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WIPF2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003779 | actin binding |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- |
WIPF2 for ontologies About GeneDecksing
|
Pathways & Interactions
for WIPF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of actin dynamics for phagocytic cup formation | | | 2 | Cytoskeleton remodeling_Reverse signaling by ephrin B | | | 3 | Immune System | | | 4 | Cell adhesion_Integrin-mediated cell adhesion and migration | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for WIPF2
2  GeneGo (Thomson Reuters) Pathways for WIPF2
5/6 
Reactome Pathways for WIPF2 (see all 6)
WIPF2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WIPF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/12 Interacting proteins for WIPF2 (Q8TF741, 2, 3 ENSP000003209244) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
|
Drugs & Compounds
for WIPF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WIPF2
Search CenterWatch for drugs/clinical trials and news about WIPF2
|
Transcripts
for WIPF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WIPF2 gene: NM_133264.4 Unigene Clusters for WIPF2: WAS/WASL interacting protein family, member 2 Hs.421622 [show with all ESTs], Hs.731598 [show with all ESTs]Unigene Representative Sequences: NM_133264, BC03056111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000583268 ENST00000494757 ENST00000323571(uc002hug.1 uc002huh.1 uc010cww.1 uc002hui.1 uc010cwx.1 uc010cwy.1)
ENST00000582781 ENST00000585043 ENST00000394103 ENST00000583130 ENST00000584296
ENST00000578304(uc010cwv.1) ENST00000578623 ENST00000536600
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WIPF2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WIPF2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WIPF2 (NM_133264) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WIPF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WIPF2 |
Additional cDNA sequence: BC030561.1 18 DOTS entries: DT.95150088 DT.448673 DT.95369685 DT.100654097 DT.70104188 DT.100649406 DT.121001438 DT.97824892 DT.95290475 DT.100707218 DT.121001513 DT.95092488 DT.121001444 DT.121001458 DT.95200423 DT.95369684 DT.97847762 DT.121001461 24/386 AceView cDNA sequences (see all 386): BM678476 CA950588 CB134940 CA868332 BU733690 AA373022 AI453637 BC065551 CB162927 NM_133264 AI379979 AU119866 CR607942 BM709928 BU166009 BQ775106 AL834239 BM983050 CB122071 BM456938 BM313371 BU727483 AA594623 BM456939
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for WIPF2 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 |
|---|
|
| SP1: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WIPF2
|
Expression
for WIPF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WIPF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCTTAATT
About this image
See WIPF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WIPF2
SOURCE GeneReport for Unigene clusters: Hs.421622 Hs.731598
UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74Tissue specificity: Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, withhigh expression in brain, kidney, lung, and placenta
SABiosciences Custom PCR Arrays for WIPF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WIPF2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF2 |
Orthologs
for WIPF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WIPF2 gene from 8/21 species (see all 21) About this table
ENSEMBL Gene Tree for WIPF2 (if available)
TreeFam Gene Tree for WIPF2 (if available) |
Paralogs
for WIPF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WIPF2 gene
- WIPF32 WIPF12
1 SIMAP similar gene for WIPF2 using alignment to 5 protein entries: WIPF2_HUMAN (see all proteins):WIPF1
WIPF2 for paralogs About GeneDecksing
|
Genomic Variants
for WIPF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WIPF2 (38375556 - 38440388 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for WIPF2
2 CNVs: 102452 49856
1 Indel: 45540 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WIPF2 |
|
Disorders
/ Diseases
for WIPF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WIPF2 for disorders About GeneDecksing
OMIM gene information: 609692
OMIM disorders: --
9  diseases for WIPF2: About MalaCardsolecranon bursitis wiskott-aldrich syndrome peripheral retinal degeneration retinal perforation
bursitis laryngeal tuberculosis retinal degeneration laryngitis
retinitis
1 disease from the University of Copenhagen DISEASES database for WIPF2:Hemopericardium Export disorders for WIPF2 gene to outside databases
|
Publications
for WIPF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WIPF2 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with WIPF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. (PubMed id 12213210)1, 2, 3, 9 Aspenstroem P. (2002)
- WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. (PubMed id 11829459)1, 2, 3, 9 Kato M....Takenawa T. (2002)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS. (PubMed id 19531213)1 Havrylov S....Redowicz M.J. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for WIPF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WIPF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WIPF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WIPF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WIPF2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WIPF2 gene:
Search GeneIP for patents involving WIPF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WIPF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WIPF2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WIPF2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WIPF2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WIPF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WIPF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WIPF2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF2 |
|  |  |  | | | | ThermoFisher Antibodies for WIPF2 |
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