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Aliases for WIPF2 Gene

Aliases for WIPF2 Gene

  • WAS/WASL Interacting Protein Family, Member 2 2 3
  • WASP-Interacting Protein-Related Protein 3 4
  • WIP- And CR16-Homologous Protein 3 4
  • WIP-Related Protein 3 4
  • WICH 3 4
  • WIRE 3 4
  • WASP-Binding Protein 3

External Ids for WIPF2 Gene

Previous GeneCards Identifiers for WIPF2 Gene

  • GC17P035630
  • GC17P038375
  • GC17P034168

Summaries for WIPF2 Gene

Entrez Gene Summary for WIPF2 Gene

  • This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]

GeneCards Summary for WIPF2 Gene

WIPF2 (WAS/WASL Interacting Protein Family, Member 2) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include actin binding. An important paralog of this gene is WIPF1.

UniProtKB/Swiss-Prot for WIPF2 Gene

  • Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.

Gene Wiki entry for WIPF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIPF2 Gene

Genomics for WIPF2 Gene

Regulatory Elements for WIPF2 Gene

Genomic Location for WIPF2 Gene

Chromosome:
17
Start:
40,219,304 bp from pter
End:
40,284,136 bp from pter
Size:
64,833 bases
Orientation:
Plus strand

Genomic View for WIPF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WIPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPF2 Gene

Proteins for WIPF2 Gene

  • Protein details for WIPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF74-WIPF2_HUMAN
    Recommended name:
    WAS/WASL-interacting protein family member 2
    Protein Accession:
    Q8TF74
    Secondary Accessions:
    • A8K0L3
    • Q658J8
    • Q71RE1
    • Q8TE44

    Protein attributes for WIPF2 Gene

    Size:
    440 amino acids
    Molecular mass:
    46289 Da
    Quaternary structure:
    • Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions. No interaction was seen with WASF2 and WASF3.
    Miscellaneous:
    • Access to the profilin-binding site is masked in the full-length protein
    SequenceCaution:
    • Sequence=AAQ15232.1; Type=Frameshift; Positions=373; Evidence={ECO:0000305};

    Alternative splice isoforms for WIPF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WIPF2 Gene

Proteomics data for WIPF2 Gene at MOPED

Post-translational modifications for WIPF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WIPF2 Gene

No data available for DME Specific Peptides for WIPF2 Gene

Domains & Families for WIPF2 Gene

Protein Domains for WIPF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for WIPF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF74

UniProtKB/Swiss-Prot:

WIPF2_HUMAN :
  • Contains 1 WH2 domain.
  • Belongs to the verprolin family.
Domain:
  • Contains 1 WH2 domain.
Family:
  • Belongs to the verprolin family.
genes like me logo Genes that share domains with WIPF2: view

No data available for Gene Families for WIPF2 Gene

Function for WIPF2 Gene

Molecular function for WIPF2 Gene

UniProtKB/Swiss-Prot Function:
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.

Gene Ontology (GO) - Molecular Function for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0005515 protein binding IPI 20936779
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with WIPF2: view

Phenotypes for WIPF2 Gene

genes like me logo Genes that share phenotypes with WIPF2: view

Animal Model Products

CRISPR Products

miRNA for WIPF2 Gene

miRTarBase miRNAs that target WIPF2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WIPF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WIPF2 Gene

Localization for WIPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPF2 Gene

Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WIPF2 Gene COMPARTMENTS Subcellular localization image for WIPF2 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005884 actin filament IBA --
GO:0030479 actin cortical patch IBA --
genes like me logo Genes that share ontologies with WIPF2: view

Pathways & Interactions for WIPF2 Gene

genes like me logo Genes that share pathways with WIPF2: view

Gene Ontology (GO) - Biological Process for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000147 actin cortical patch assembly IBA --
GO:0006897 endocytosis IBA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008360 regulation of cell shape IBA --
GO:0030048 actin filament-based movement IBA --
genes like me logo Genes that share ontologies with WIPF2: view

No data available for SIGNOR curated interactions for WIPF2 Gene

Drugs & Compounds for WIPF2 Gene

No Compound Related Data Available

Transcripts for WIPF2 Gene

Unigene Clusters for WIPF2 Gene

WAS/WASL interacting protein family, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WIPF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WIPF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - - - -
SP5: -
SP6: - - - - - - -
SP7: - -

Relevant External Links for WIPF2 Gene

GeneLoc Exon Structure for
WIPF2
ECgene alternative splicing isoforms for
WIPF2

Expression for WIPF2 Gene

mRNA expression in normal human tissues for WIPF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WIPF2 Gene

This gene is overexpressed in Pancreas (14.5), Heart (13.8), Frontal cortex (13.3), and Pancreatic juice (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WIPF2 Gene



SOURCE GeneReport for Unigene cluster for WIPF2 Gene Hs.421622

mRNA Expression by UniProt/SwissProt for WIPF2 Gene

Q8TF74-WIPF2_HUMAN
Tissue specificity: Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta.
genes like me logo Genes that share expression patterns with WIPF2: view

Protein tissue co-expression partners for WIPF2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for WIPF2 Gene

Orthologs for WIPF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WIPF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WIPF2 35
  • 91.4 (n)
  • 93.72 (a)
WIPF2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WIPF2 35
  • 93.81 (n)
  • 97.22 (a)
WIPF2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wipf2 35
  • 89.4 (n)
  • 93.74 (a)
Wipf2 16
Wipf2 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wipf2 35
  • 88.01 (n)
  • 93.74 (a)
oppossum
(Monodelphis domestica)
Mammalia WIPF2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WIPF2 36
  • 43 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WIPF2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves WIPF2 35
  • 74.76 (n)
  • 84.76 (a)
WIPF2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WIPF2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4454 35
wipf2 35
  • 66.5 (n)
  • 73.3 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69127 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12755 35
wipf2b 35
  • 63.11 (n)
  • 68.93 (a)
WIPF2 (2 of 2) 36
  • 52 (a)
OneToMany
wipf2b 36
  • 66 (a)
OneToMany
Species with no ortholog for WIPF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WIPF2 Gene

ENSEMBL:
Gene Tree for WIPF2 (if available)
TreeFam:
Gene Tree for WIPF2 (if available)

Paralogs for WIPF2 Gene

Paralogs for WIPF2 Gene

(1) SIMAP similar genes for WIPF2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WIPF2: view

Variants for WIPF2 Gene

Sequence variations from dbSNP and Humsavar for WIPF2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12391 -- 40,282,549(-) TAATC(A/T)GAATA downstream-variant-500B, utr-variant-3-prime
rs12974 -- 40,282,550(-) GTAAT(C/T)AGAAT downstream-variant-500B, utr-variant-3-prime
rs15573 -- 40,282,584(-) GAAAA(A/T)ATCAA downstream-variant-500B, utr-variant-3-prime
rs935142 -- 40,283,233(-) TAAGG(A/C)CCATC utr-variant-3-prime
rs1807273 -- 40,283,055(+) ATGGC(A/G)CATGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WIPF2 Gene

Variant ID Type Subtype PubMed ID
nsv833444 CNV Loss 17160897
nsv525796 CNV Gain 19592680
esv2430508 CNV Deletion 19546169
esv2372222 CNV Deletion 18987734
esv2715907 CNV Deletion 23290073
esv2668303 CNV Deletion 23128226
dgv179n21 CNV Loss 19592680
esv2676976 CNV Deletion 23128226

Variation tolerance for WIPF2 Gene

Residual Variation Intolerance Score: 41.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WIPF2 Gene

HapMap Linkage Disequilibrium report
WIPF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIPF2 Gene

Disorders for WIPF2 Gene

Relevant External Links for WIPF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WIPF2
genes like me logo Genes that share disorders with WIPF2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WIPF2 Gene

Publications for WIPF2 Gene

  1. The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. (PMID: 12213210) Aspenstroem P. (Exp. Cell Res. 2002) 2 23 67
  2. WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. (PMID: 11829459) Kato M. … Takenawa T. (Biochem. Biophys. Res. Commun. 2002) 2 23 67
  3. A complex of Wiskott-Aldrich syndrome protein with mammalian verprolins plays an important role in monocyte chemotaxis. (PMID: 16709815) Tsuboi S. (J. Immunol. 2006) 23 67
  4. The mammalian verprolin homologue WIRE participates in receptor-mediated endocytosis and regulation of the actin filament system by distinct mechanisms. (PMID: 15265696) AspenstrAPm P. (Exp. Cell Res. 2004) 23 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for WIPF2 Gene

Sources for WIPF2 Gene

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