Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



WIPF2 Gene

protein-coding   GIFtS: 57
GCID: GC17P038375

WAS/WASL Interacting Protein Family, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
WAS/WASL Interacting Protein Family, Member 21 2     WIP- And CR16-Homologous Protein2 3
WICH2 3 5     WIP-Related Protein2 3
WIRE2 3 5     WAS/WASL-Interacting Protein Family Member 22
WASP-Interacting Protein-Related Protein2 3     WASP-Binding Protein2

External Ids:    HGNC: 309231   Entrez Gene: 1471792   Ensembl: ENSG000001714757   OMIM: 6096925   UniProtKB: Q8TF743   

Export aliases for WIPF2 gene to outside databases

Previous GC identifers: GC17P035630 GC17P034168


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for WIPF2 Gene:
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role
in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the
activated platelet-derived growth factor receptor and the actin polymerization machinery. (provided by RefSeq,
Jul 2008)

GeneCards Summary for WIPF2 Gene:
WIPF2 (WAS/WASL interacting protein family, member 2) is a protein-coding gene. Diseases associated with WIPF2 include laryngeal tuberculosis, and olecranon bursitis. GO annotations related to this gene include actin binding. An important paralog of this gene is WIPF1.

UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74
Function: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB
receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate
with WASP and WASL to induce mobilization and reorganization of the actin filament system

Gene Wiki entry for WIPF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WIPF2 gene promoter:
         AhR   Sox5   NF-1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   NF-kappaB   Arnt   MZF-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWIPF2 promoter sequence
   Search Chromatin IP Primers for WIPF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WIPF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.1   HGNC cytogenetic band: 17q21.2

WIPF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WIPF2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P038375:  view genomic region     (about GC identifiers)

Start:
38,375,556 bp from pter      End:
38,440,388 bp from pter
Size:
64,833 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74 (See protein sequence)
Recommended Name: WAS/WASL-interacting protein family member 2  
Size: 440 amino acids; 46289 Da
Subunit: Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two
proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions. No
interaction was seen with WASF2 and WASF3
Miscellaneous: Access to the profilin-binding site is masked in the full-length protein
Sequence caution: Sequence=AAQ15232.1; Type=Frameshift; Positions=373;
Secondary accessions: A8K0L3 Q658J8 Q71RE1 Q8TE44
Alternative splicing: 2 isoforms:  Q8TF74-1   Q8TF74-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WIPF2: NX_Q8TF74

Explore proteomics data for WIPF2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WIPF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_573571.1  
    ENSEMBL proteins: 
     ENSP00000462386   ENSP00000320924   ENSP00000463869   ENSP00000462826   ENSP00000377663  
     ENSP00000462350   ENSP00000463149   ENSP00000439175  
    Reactome Protein details: Q8TF74

    WIPF2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for WIPF2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for WIPF2
    GenScript Custom Purified and Recombinant Proteins Services for WIPF2
    Novus Biologicals WIPF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WIPF2

    WIPF2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WIPF2
    Novus Biologicals WIPF2 Antibodies
    Abcam antibodies for WIPF2
    Cloud-Clone Corp. Antibodies for WIPF2
    ThermoFisher Antibodies for WIPF2
    LSBio Antibodies in human, mouse, rat for WIPF2

    WIPF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WIPF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WIPF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WIPF2
    Cloud-Clone Corp. CLIAs for WIPF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry Q8TF74

    ProtoNet protein and cluster: Q8TF74

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74
    Similarity: Belongs to the verprolin family
    Similarity: Contains 1 WH2 domain


    WIPF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WIPF2_HUMAN, Q8TF74
    Function: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB
    receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate
    with WASP and WASL to induce mobilization and reorganization of the actin filament system

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--
         
    WIPF2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WIPF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WIPF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WIPF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WIPF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target WIPF2:
    hsa-mir-92a-3p (MIRT049127)

    Block miRNA regulation of human, mouse, rat WIPF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WIPF2 (see all 121):
    hsa-miR-4254 hsa-miR-520e hsa-miR-607 hsa-miR-3194-5p hsa-miR-106a hsa-miR-1224-3p hsa-miR-1245 hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WIPF2
    Predesigned siRNA for gene silencing in human, mouse, rat WIPF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WIPF2

    Clone
    Products:
         
    OriGene clones in human, mouse for WIPF2 (see all 8)
    OriGene ORF clones in mouse, rat for WIPF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WIPF2 (NM_133264)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WIPF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WIPF2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WIPF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for WIPF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    WIPF2_HUMAN, Q8TF74: Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--

    WIPF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for WIPF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    2Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside in signaling0.37
    3EphB-EphrinB Signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for WIPF2
        Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B

    1 Reactome Pathway for WIPF2
        Regulation of actin dynamics for phagocytic cup formation



    WIPF2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WIPF2
    Interactions:

        GeneGlobe Interaction Network for WIPF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WIPF2 (Q8TF741, 2, 3 ENSP000003209244) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 3, ENSP000003390074EBI-2850112,EBI-401755 I2D: score=3 STRING: ENSP00000339007
    WWOXQ9NZC72, 3, ENSP000003861614MINT-72784 I2D: score=3 STRING: ENSP00000386161
    DNMBPQ6XZF73, ENSP000003156594I2D: score=3 STRING: ENSP00000315659
    WASP427683, ENSP000003658914I2D: score=3 STRING: ENSP00000365891
    APBB1O002133, ENSP000002994024I2D: score=2 STRING: ENSP00000299402
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    WIPF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WIPF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for WIPF2 gene: 
    NM_133264.4  

    Unigene Cluster for WIPF2:

    WAS/WASL interacting protein family, member 2
    Hs.421622  [show with all ESTs]
    Unigene Representative Sequence: NM_133264
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583268 ENST00000494757 ENST00000323571(uc002hug.1 uc002huh.1 uc010cww.1 uc002hui.1 uc010cwx.1 uc010cwy.1)
    ENST00000582781 ENST00000585043 ENST00000394103 ENST00000583130 ENST00000584296
    ENST00000578304(uc010cwv.1) ENST00000578623 ENST00000536600
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WIPF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WIPF2 (see all 121):
    hsa-miR-4254 hsa-miR-520e hsa-miR-607 hsa-miR-3194-5p hsa-miR-106a hsa-miR-1224-3p hsa-miR-1245 hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WIPF2
    Predesigned siRNA for gene silencing in human, mouse, rat WIPF2
    Clone
    Products:
         
    OriGene clones in human, mouse for WIPF2 (see all 8)
    OriGene ORF clones in mouse, rat for WIPF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WIPF2 (NM_133264)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WIPF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WIPF2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WIPF2
    OriGene qSTAR qPCR primer pairs in human, mouse for WIPF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WIPF2
      QuantiTect SYBR Green Assays in human, mouse, rat WIPF2
      QuantiFast Probe-based Assays in human, mouse, rat WIPF2

    Additional mRNA sequence: 

    AB043786.1 AF370396.1 AJ431177.1 AK026913.1 AK055025.1 AK055057.1 AK289578.1 AK289779.1 
    AK290301.1 AK311544.1 AK315836.1 AL834239.1 BC019706.1 BC025965.1 BC043408.1 BC047435.1 
    BC064504.1 BC065551.1 U90911.1 

    16 DOTS entries:

    DT.95150088  DT.448673  DT.95369685  DT.100654097  DT.100649406  DT.121001438  DT.97824892  DT.95290475 
    DT.100707218  DT.121001513  DT.121001444  DT.121001458  DT.95200423  DT.97847762  DT.121001461  DT.95092488 

    Selected AceView cDNA sequences (see all 386):

    BM456939 AL044567 AA995642 AW675087 AA644667 AW263106 AI683408 W79928 
    BM052838 AI961529 Z39870 AI217937 BE550068 AI092765 AW665044 BQ774047 
    CR607942 BQ231120 BG230612 U90911 AA373022 N58620 CD671700 CA950353 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WIPF2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:              -                       -                                                               
    SP2:                                      -     -     -     -     -     -                                 
    SP3:                                                                          -                           
    SP4:              -           -     -     -     -     -     -     -     -                                 
    SP5:              -                                                                                       


    ECgene alternative splicing isoforms for WIPF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    WIPF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTTAATT
    WIPF2 Expression
    About this image


    WIPF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
    WIPF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WIPF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.421622

    UniProtKB/Swiss-Prot: WIPF2_HUMAN, Q8TF74
    Tissue specificity: Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed,
    with high expression in brain, kidney, lung, and placenta

        Custom PCR Arrays for WIPF2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WIPF2
    OriGene qSTAR qPCR primer pairs in human, mouse for WIPF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WIPF2
    QuantiTect SYBR Green Assays in human, mouse, rat WIPF2
    QuantiFast Probe-based Assays in human, mouse, rat WIPF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for WIPF2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wipf21 , 5 WAS/WASL interacting protein family, member 21, 5 89.4(n)1
    93.74(a)1
      11 (62.71 cM)5
    685241  NM_197940.21  NP_922922.11 
     988636385 
    chicken
    (Gallus gallus)
    Aves WIPF21 WAS/WASL interacting protein family, member 2 74.76(n)
    84.76(a)
      771898  XM_001235112.3  XP_001235113.2 
    lizard
    (Anolis carolinensis)
    Reptilia WIPF26
    WAS/WASL interacting protein family, member 2
    81(a)
    1 ↔ 1
    6(69595881-69623222)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691272 hypothetical protein MGC69127 76.38(n)    BC057751.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.127552 Danio rerio, clone IMAGE5413379, mRNA 72.9(n)    BC045975.1 


    ENSEMBL Gene Tree for WIPF2 (if available)
    TreeFam Gene Tree for WIPF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for WIPF2 gene
    WIPF12  
    1 SIMAP similar gene for WIPF2 using alignment to 5 protein entries:     WIPF2_HUMAN (see all proteins):
    WIPF1

    WIPF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for WIPF2 (see all 1249)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866478811,2
    --38373643(+) GGCCTC/TCCAAA 1 -- us2k10--------
    rs1914544971,2
    --38373655(+) TGCTGC/GGATTA 1 -- us2k10--------
    rs1178617591,2
    F--38373682(+) TGCCCG/CGTTAT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1848351891,2
    --38373849(+) ATATCA/TCTATT 1 -- us2k10--------
    rs1501832221,2
    C--38373907(+) CTTAT-/CACAGAG 1 -- us2k10--------
    rs1894488281,2
    --38373929(+) AGCATA/GGGGCT 1 -- us2k10--------
    rs1460075321,2
    C--38373932(+) ATGGGA/GCTTTA 1 -- us2k10--------
    rs1167674251,2
    F--38373987(+) TTGCAG/ATAAGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1814149951,2
    --38373992(+) GTAAGC/GCTTGA 1 -- us2k10--------
    rs1399096541,2
    --38374098(+) AATGTA/GGAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WIPF2 (38375556 - 38440388 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for WIPF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668303CNV Deletion23128226
    esv2715907CNV Deletion23290073
    esv2430508CNV Deletion19546169
    esv2676976CNV Deletion23128226
    esv2372222CNV Deletion18987734
    dgv179n21CNV Loss19592680
    nsv833444CNV Loss17160897
    nsv525796CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WIPF2
    DNA2.0 Custom Variant and Variant Library Synthesis for WIPF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609692    OMIM disorders: --

    15 diseases for WIPF2:    
    About MalaCards
    laryngeal tuberculosis    olecranon bursitis    hemopericardium    retinal perforation
    bursitis    peripheral retinal degeneration    wiskott-aldrich syndrome    retinal degeneration
    laryngitis    retinitis    tuberculosis    tonsillitis
    cerebritis    breast cancer    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for WIPF2:
    Laryngeal tuberculosis     Peripheral retinal degeneration

    WIPF2 for disorders           About GeneDecksing


    Export disorders for WIPF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for WIPF2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with WIPF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. (PubMed id 12213210)1, 2, 3, 9 Aspenstroem P. (Exp. Cell Res. 2002)
    2. WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. (PubMed id 11829459)1, 2, 3, 9 Kato M....Takenawa T. (Biochem. Biophys. Res. Commun. 2002)
    3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion. (PubMed id 23295955)1 Lehtinen L....Iljin K. (Oncotarget 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (PLoS ONE 2012)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (Nat. Biotechnol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 147179 HGNC: 30923 AceView: WIRE Ensembl:ENSG00000171475 euGenes: HUgn147179
    ECgene: WIPF2 H-InvDB: WIPF2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for WIPF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for WIPF2 gene:
    Search GeneIP for patents involving WIPF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for WIPF2  
     OriGene qPCR primer pairs and template standards for WIPF2   OriGene Protein Over-expression Lysate for WIPF2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for WIPF2  
     OriGene qSTAR qPCR primer pairs in human, mouse for WIPF2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for WIPF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WIPF2   OriGene Custom Protein Services for WIPF2  

     
     
     Block miRNA regulation of human, mouse, rat WIPF2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing WIPF2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WIPF2 Predesigned siRNA for gene silencing in human, mouse, rat WIPF2
     QuantiFast Probe-based Assays in human, mouse, rat WIPF2 QuantiTect SYBR Green Assays in human, mouse, rat WIPF2
     Custom PCR Arrays for WIPF2 Search Chromatin IP Primers for WIPF2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WIPF2  GeneGlobe Interaction Network for WIPF2
     Regulatory tfbs in WIPF2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for WIPF2 GenScript cDNA clones with any tag delivered in your preferred vector for WIPF2
     GenScript Custom Assay Services for WIPF2 GenScript Custom overexpressing Cell Line Services for WIPF2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for WIPF2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     WIPF2 antibodies
     WIPF2 lysates
     Antibodies for WIPF2
     See all of Abcam's Antibodies, Kits and Proteins for WIPF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for WIPF2
     Antibodies for WIPF2
     ELISAs for WIPF2
     CLIAs for WIPF2



     Browse ESI BIO Cell Lines and PureStem Progenitors for WIPF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for WIPF2
     SwitchGear Promoter luciferase reporter plasmids for WIPF2
     ThermoFisher Antibodies for WIPF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WIPF2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WIPF2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WIPF2
     LSBio Antibodies in human, mouse, rat for WIPF2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WIPF2 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4