Aliases for WIPF2 Gene
External Ids for WIPF2 Gene
Previous GeneCards Identifiers for WIPF2 Gene
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]
GeneCards Summary for WIPF2 Gene
WIPF2 (WAS/WASL Interacting Protein Family Member 2) is a Protein Coding gene. Diseases associated with WIPF2 include wiskott-aldrich syndrome and hemopericardium. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include actin binding. An important paralog of this gene is WIPF1.
UniProtKB/Swiss-Prot for WIPF2 Gene
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.