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Aliases for WIPF2 Gene

Aliases for WIPF2 Gene

  • WAS/WASL Interacting Protein Family Member 2 2 3 5
  • WASP-Interacting Protein-Related Protein 3 4
  • WIP- And CR16-Homologous Protein 3 4
  • WIP-Related Protein 3 4
  • WICH 3 4
  • WIRE 3 4
  • WAS/WASL Interacting Protein Family, Member 2 2
  • WAS/WASL-Interacting Protein Family Member 2 3
  • WASP-Binding Protein 3

External Ids for WIPF2 Gene

Previous GeneCards Identifiers for WIPF2 Gene

  • GC17P035630
  • GC17P038375
  • GC17P034168

Summaries for WIPF2 Gene

Entrez Gene Summary for WIPF2 Gene

  • This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]

GeneCards Summary for WIPF2 Gene

WIPF2 (WAS/WASL Interacting Protein Family Member 2) is a Protein Coding gene. Among its related pathways are Immune System and EphB-EphrinB Signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is WIPF1.

UniProtKB/Swiss-Prot for WIPF2 Gene

  • Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.

Gene Wiki entry for WIPF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIPF2 Gene

Genomics for WIPF2 Gene

Regulatory Elements for WIPF2 Gene

Enhancers for WIPF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F040193 1 Ensembl ENCODE 12.6 -24.9 -24904 1.2 ZNF76 KLF17 GLI4 ZNF2 ZEB1 GLIS2 SCRT2 ZNF143 ZNF548 EGR2 ENSG00000266469 CDK12 MED1 LOC105371776 MSL1 WIPF2 CDC6 RPL23AP75 RPL19 ENSG00000266208
GH17F040191 1.1 ENCODE 12.5 -27.5 -27501 1.2 HDGF ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 SLC30A9 GLIS2 ZNF143 MSL1 WIPF2 CDC6 MIR6866 CASC3 THRA RARA MIR6867 RAPGEFL1
GH17F040250 1.3 Ensembl ENCODE 12.1 +32.3 32329 1.8 PKNOX1 INSM2 KLF17 SIN3A FEZF1 ZNF121 ZNF366 RCOR1 ZNF391 ZNF362 RAPGEFL1 MSL1 WIPF2 CDC6 TOP2A ENSG00000266208 GC17M040243 RNY4P8
GH17F040275 0.6 Ensembl ENCODE 11.6 +56.3 56272 0.9 ADNP ZBTB33 NFE2 PRDM10 KDM1A SPI1 WIPF2 RARA TOP2A ENSG00000266208 THRA GC17P040282 PIR47746 GC17P040270
GH17F040190 0.5 ENCODE 11.5 -28.7 -28681 0.2 HDGF CTCF SAP130 ZNF48 KAT2B TEAD3 POLR2A SCRT2 ZNF143 GATAD2A MSL1 CDC6 WIPF2 MIR6866 CASC3 THRA RARA MIR6867 RAPGEFL1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WIPF2 on UCSC Golden Path with GeneCards custom track

Promoters for WIPF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001345925 396 2601 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for WIPF2 Gene

Chromosome:
17
Start:
40,219,304 bp from pter
End:
40,284,136 bp from pter
Size:
64,833 bases
Orientation:
Plus strand

Genomic View for WIPF2 Gene

Genes around WIPF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WIPF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WIPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPF2 Gene

Proteins for WIPF2 Gene

  • Protein details for WIPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF74-WIPF2_HUMAN
    Recommended name:
    WAS/WASL-interacting protein family member 2
    Protein Accession:
    Q8TF74
    Secondary Accessions:
    • A8K0L3
    • Q658J8
    • Q71RE1
    • Q8TE44

    Protein attributes for WIPF2 Gene

    Size:
    440 amino acids
    Molecular mass:
    46289 Da
    Quaternary structure:
    • Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions. No interaction was seen with WASF2 and WASF3.
    Miscellaneous:
    • Access to the profilin-binding site is masked in the full-length protein.
    SequenceCaution:
    • Sequence=AAQ15232.1; Type=Frameshift; Positions=373; Evidence={ECO:0000305};

    Alternative splice isoforms for WIPF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WIPF2 Gene

Post-translational modifications for WIPF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WIPF2 Gene

Domains & Families for WIPF2 Gene

Protein Domains for WIPF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for WIPF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF74

UniProtKB/Swiss-Prot:

WIPF2_HUMAN :
  • Contains 1 WH2 domain.
  • Belongs to the verprolin family.
Domain:
  • Contains 1 WH2 domain.
Family:
  • Belongs to the verprolin family.
genes like me logo Genes that share domains with WIPF2: view

No data available for Gene Families for WIPF2 Gene

Function for WIPF2 Gene

Molecular function for WIPF2 Gene

UniProtKB/Swiss-Prot Function:
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.

Gene Ontology (GO) - Molecular Function for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 20936779
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with WIPF2: view
genes like me logo Genes that share phenotypes with WIPF2: view

Animal Model Products

miRNA for WIPF2 Gene

miRTarBase miRNAs that target WIPF2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WIPF2 Gene

Localization for WIPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPF2 Gene

Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WIPF2 Gene COMPARTMENTS Subcellular localization image for WIPF2 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005884 actin filament IBA --
GO:0030479 NOT actin cortical patch IBA --
genes like me logo Genes that share ontologies with WIPF2: view

Pathways & Interactions for WIPF2 Gene

genes like me logo Genes that share pathways with WIPF2: view

Gene Ontology (GO) - Biological Process for WIPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000147 NOT actin cortical patch assembly IBA --
GO:0006897 endocytosis IBA --
GO:0008360 regulation of cell shape IBA --
GO:0030048 actin filament-based movement IBA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with WIPF2: view

No data available for SIGNOR curated interactions for WIPF2 Gene

Transcripts for WIPF2 Gene

Unigene Clusters for WIPF2 Gene

WAS/WASL interacting protein family, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WIPF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - - - -
SP5: -
SP6: - - - - - - -
SP7: - -

Relevant External Links for WIPF2 Gene

GeneLoc Exon Structure for
WIPF2
ECgene alternative splicing isoforms for
WIPF2

Expression for WIPF2 Gene

mRNA expression in normal human tissues for WIPF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WIPF2 Gene

This gene is overexpressed in Pancreas (14.5), Heart (13.8), Frontal cortex (13.3), and Pancreatic juice (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WIPF2 Gene



Protein tissue co-expression partners for WIPF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WIPF2 Gene:

WIPF2

SOURCE GeneReport for Unigene cluster for WIPF2 Gene:

Hs.421622

mRNA Expression by UniProt/SwissProt for WIPF2 Gene:

Q8TF74-WIPF2_HUMAN
Tissue specificity: Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta.
genes like me logo Genes that share expression patterns with WIPF2: view

Primer Products

No data available for mRNA differential expression in normal tissues for WIPF2 Gene

Orthologs for WIPF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WIPF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WIPF2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WIPF2 34 35
  • 93.81 (n)
cow
(Bos Taurus)
Mammalia WIPF2 34 35
  • 91.4 (n)
mouse
(Mus musculus)
Mammalia Wipf2 34 16 35
  • 89.4 (n)
rat
(Rattus norvegicus)
Mammalia Wipf2 34
  • 88.01 (n)
oppossum
(Monodelphis domestica)
Mammalia WIPF2 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WIPF2 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves WIPF2 34 35
  • 74.76 (n)
lizard
(Anolis carolinensis)
Reptilia WIPF2 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wipf2 34
  • 66.5 (n)
Str.4454 34
African clawed frog
(Xenopus laevis)
Amphibia MGC69127 34
zebrafish
(Danio rerio)
Actinopterygii wipf2b 34 35
  • 63.11 (n)
WIPF2 (2 of 2) 35
  • 52 (a)
OneToMany
Dr.12755 34
Species where no ortholog for WIPF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WIPF2 Gene

ENSEMBL:
Gene Tree for WIPF2 (if available)
TreeFam:
Gene Tree for WIPF2 (if available)

Paralogs for WIPF2 Gene

Paralogs for WIPF2 Gene

(1) SIMAP similar genes for WIPF2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WIPF2: view

Variants for WIPF2 Gene

Sequence variations from dbSNP and Humsavar for WIPF2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10611992 -- 40,282,480(+) GTTCA(-/TCTG)TCTGC downstream-variant-500B, utr-variant-3-prime
rs11078939 -- 40,253,447(+) GGGAT(G/T)CAAAG intron-variant
rs11078940 -- 40,253,812(+) GAAGA(C/T)TTTTA intron-variant
rs111263237 -- 40,232,480(+) TACCA(C/T)CATGC intron-variant
rs111319305 -- 40,274,282(+) AGCTA(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WIPF2 Gene

Variant ID Type Subtype PubMed ID
dgv179n21 CNV loss 19592680
esv2372222 CNV deletion 18987734
esv2430508 CNV deletion 19546169
esv2668303 CNV deletion 23128226
esv2676976 CNV deletion 23128226
esv2715907 CNV deletion 23290073
esv3156012 CNV deletion 24192839
esv3554412 CNV deletion 23714750
esv3640553 CNV loss 21293372
nsv1071066 CNV deletion 25765185
nsv1112294 CNV deletion 24896259
nsv1121524 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv525796 CNV gain 19592680
nsv833444 CNV loss 17160897
nsv955414 CNV deletion 24416366

Variation tolerance for WIPF2 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WIPF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WIPF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIPF2 Gene

Disorders for WIPF2 Gene

Relevant External Links for WIPF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WIPF2

No disorders were found for WIPF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WIPF2 Gene

Publications for WIPF2 Gene

  1. WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation. (PMID: 11829459) Kato M. … Takenawa T. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 22 64
  2. The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. (PMID: 12213210) Aspenstroem P. (Exp. Cell Res. 2002) 2 3 4 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64

Products for WIPF2 Gene

Sources for WIPF2 Gene

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