Aliases for WIPF2 Gene
External Ids for WIPF2 Gene
Previous GeneCards Identifiers for WIPF2 Gene
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]
GeneCards Summary for WIPF2 Gene
WIPF2 (WAS/WASL Interacting Protein Family, Member 2) is a Protein Coding gene. Diseases associated with WIPF2 include laryngeal tuberculosis and peripheral retinal degeneration. Among its related pathways are Fcgamma receptor (FCGR) dependent phagocytosis and Cell adhesion Integrin-mediated cell adhesion and migration. GO annotations related to this gene include actin binding. An important paralog of this gene is WIPF1.
UniProtKB/Swiss-Prot for WIPF2 Gene
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.