Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WIPF1 Gene

Aliases for WIPF1 Gene

  • WAS/WASL Interacting Protein Family, Member 1 2 3
  • WASPIP 3 4 6
  • WIP 3 4 6
  • Wiskott-Aldrich Syndrome Protein Interacting Protein 2 3
  • WASP-Interacting Protein 3 4
  • Protein PRPL-2 3 4
  • Wiskott-Aldrich Syndrome Protein-Interacting Protein 4
  • WAS/WASL-Interacting Protein Family Member 1 3
  • PRPL-2 3
  • WAS2 3

External Ids for WIPF1 Gene

Previous HGNC Symbols for WIPF1 Gene

  • WASPIP

Previous GeneCards Identifiers for WIPF1 Gene

  • GC02M175133
  • GC02M175424
  • GC02M167305

Summaries for WIPF1 Gene

Entrez Gene Summary for WIPF1 Gene

  • This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WIPF1 Gene

WIPF1 (WAS/WASL Interacting Protein Family, Member 1) is a Protein Coding gene. Diseases associated with WIPF1 include wiskott-aldrich syndrome 2 and wiskott-aldrich syndrome. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is WIPF2.

UniProtKB/Swiss-Prot for WIPF1 Gene

  • Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.

Gene Wiki entry for WIPF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIPF1 Gene

Genomics for WIPF1 Gene

Regulatory Elements for WIPF1 Gene

Genomic Location for WIPF1 Gene

Start:
174,559,572 bp from pter
End:
174,682,916 bp from pter
Size:
123,345 bases
Orientation:
Minus strand

Genomic View for WIPF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WIPF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIPF1 Gene

Proteins for WIPF1 Gene

  • Protein details for WIPF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43516-WIPF1_HUMAN
    Recommended name:
    WAS/WASL-interacting protein family member 1
    Protein Accession:
    O43516
    Secondary Accessions:
    • B8ZZM1
    • D3DPE4
    • Q15220
    • Q53TA9
    • Q6MZU9
    • Q9BU37
    • Q9UNP1

    Protein attributes for WIPF1 Gene

    Size:
    503 amino acids
    Molecular mass:
    51258 Da
    Quaternary structure:
    • Binds to WAS, profilin and actin. Binds to WASL (By similarity). Interacts with DBNL.
    Miscellaneous:
    • Recruited to PIP5K-induced vesicle surfaces in the absence of functional WASL.
    SequenceCaution:
    • Sequence=AAC03767.1; Type=Frameshift; Positions=302, 310; Evidence={ECO:0000305}; Sequence=CAA60014.1; Type=Frameshift; Positions=302, 310; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WIPF1 Gene

    Alternative splice isoforms for WIPF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WIPF1 Gene

Proteomics data for WIPF1 Gene at MOPED

Post-translational modifications for WIPF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for WIPF1 Gene

Domains for WIPF1 Gene

Protein Domains for WIPF1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for WIPF1 Gene

Graphical View of Domain Structure for InterPro Entry

O43516

UniProtKB/Swiss-Prot:

WIPF1_HUMAN :
  • O43516
Domain:
  • Binds to WAS within the N-terminal region 170, at a site distinct from the CDC42-binding site
  • Contains 1 WH2 domain.
Family:
  • Belongs to the verprolin family.
genes like me logo Genes that share domains with WIPF1: view

No data available for Gene Families for WIPF1 Gene

Function for WIPF1 Gene

Molecular function for WIPF1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.

Gene Ontology (GO) - Molecular Function for WIPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 10202051
GO:0005522 profilin binding TAS 9405671
genes like me logo Genes that share ontologies with WIPF1: view

Phenotypes for WIPF1 Gene

genes like me logo Genes that share phenotypes with WIPF1: view

Animal Models for WIPF1 Gene

MGI Knock Outs for WIPF1:

Animal Model Products

CRISPR Products

miRNA for WIPF1 Gene

miRTarBase miRNAs that target WIPF1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WIPF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WIPF1 Gene

Localization for WIPF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIPF1 Gene

Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cell projection, ruffle. Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WIPF1 Gene COMPARTMENTS Subcellular localization image for WIPF1 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for WIPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005829 cytosol TAS --
GO:0005884 actin filament IEA --
GO:0015629 actin cytoskeleton TAS 9405671
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with WIPF1: view

Pathways for WIPF1 Gene

genes like me logo Genes that share pathways with WIPF1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for WIPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 9405671
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008154 actin polymerization or depolymerization IEA --
GO:0030048 actin filament-based movement IEA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with WIPF1: view

Compounds for WIPF1 Gene

(1) Novoseek inferred chemical compound relationships for WIPF1 Gene

Compound -log(P) Hits PubMed IDs
proline 28.6 2
genes like me logo Genes that share compounds with WIPF1: view

Transcripts for WIPF1 Gene

Unigene Clusters for WIPF1 Gene

WAS/WASL interacting protein family, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WIPF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WIPF1 Gene

No ASD Table

Relevant External Links for WIPF1 Gene

GeneLoc Exon Structure for
WIPF1
ECgene alternative splicing isoforms for
WIPF1

Expression for WIPF1 Gene

mRNA expression in normal human tissues for WIPF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WIPF1 Gene

This gene is overexpressed in Whole Blood (11.0).

Protein differential expression in normal tissues for WIPF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.5), Monocytes (8.9), CD8 Tcells (8.6), Lymph node (8.6), NK cells (6.2), and Cervix (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WIPF1 Gene

SOURCE GeneReport for Unigene cluster for WIPF1 Gene Hs.128067

mRNA Expression by UniProt/SwissProt for WIPF1 Gene

O43516-WIPF1_HUMAN
Tissue specificity: Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.
genes like me logo Genes that share expressions with WIPF1: view

Expression partners for WIPF1 Gene

In Situ Assay Products

Orthologs for WIPF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WIPF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WIPF1 35
  • 84.37 (n)
  • 86.53 (a)
WIPF1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WIPF1 35
  • 85.42 (n)
  • 87 (a)
WIPF1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wipf1 35
  • 84.36 (n)
  • 89.43 (a)
Wipf1 16
Wipf1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WIPF1 35
  • 99.4 (n)
  • 99.4 (a)
WIPF1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wipf1 35
  • 82.52 (n)
  • 87.34 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia WIPF1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves WIPF1 35
  • 67.34 (n)
  • 71.14 (a)
WIPF1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WIPF1 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wipf1 36
  • 56 (a)
OneToMany
WIPF1 (1 of 2) 36
  • 42 (a)
OneToMany
Species with no ortholog for WIPF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WIPF1 Gene

ENSEMBL:
Gene Tree for WIPF1 (if available)
TreeFam:
Gene Tree for WIPF1 (if available)

Paralogs for WIPF1 Gene

Paralogs for WIPF1 Gene

Selected SIMAP similar genes for WIPF1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with WIPF1: view

Variants for WIPF1 Gene

Sequence variations from dbSNP and Humsavar for WIPF1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7739 -- 174,559,701(-) TCATA(C/T)CATGC utr-variant-3-prime
rs11482 -- 174,559,727(-) ACCGT(A/C)GAGGA utr-variant-3-prime
rs15327 -- 174,560,914(+) AGTAA(C/T)ACATG utr-variant-3-prime
rs724746 -- 174,651,453(+) ATAGT(A/G)ACATA intron-variant
rs767863 -- 174,646,063(+) GGCAG(A/C)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WIPF1 Gene

Variant ID Type Subtype PubMed ID
nsv3041 CNV Insertion 18451855
nsv3042 CNV Insertion 18451855
esv2721156 CNV Deletion 23290073
esv2721157 CNV Deletion 23290073
esv2669521 CNV Deletion 23128226
nsv215436 CNV Loss 16902084
esv2676722 CNV Deletion 23128226
esv27119 CNV Loss 19812545

Relevant External Links for WIPF1 Gene

HapMap Linkage Disequilibrium report
WIPF1
Human Gene Mutation Database (HGMD)
WIPF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIPF1 Gene

Disorders for WIPF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for WIPF1 Gene in MalaCards »

(2) Diseases for WIPF1 Gene including...

(1) OMIM Diseases for WIPF1 Gene (602357)

UniProtKB/Swiss-Prot

WIPF1_HUMAN
  • Wiskott-Aldrich syndrome 2 (WAS2) [MIM:614493]: An immunodeficiency disorder characterized by eczema, thrombocytopenia, recurrent infections, defective T-cell proliferation, and impaired natural killer cell function. {ECO:0000269 PubMed:22231303}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for WIPF1 Gene

(2) Novoseek inferred disease relationships for WIPF1 Gene

Disease -log(P) Hits PubMed IDs
wiskott-aldrich syndrome 95.6 29
immunodeficiency 31.8 1

Relevant External Links for WIPF1

Genetic Association Database (GAD)
WIPF1
genes like me logo Genes that share disorders with WIPF1: view

No data available for Genatlas for WIPF1 Gene

Publications for WIPF1 Gene

  1. WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. (PMID: 9405671) Ramesh N. … Geha R.S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein. (PMID: 10202051) Stewart D.M. … Nelson D.L. (J. Immunol. 1999) 3 4 23
  3. The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast. (PMID: 10358064) Vaduva G. … Ramesh N. (J. Biol. Chem. 1999) 3 23
  4. The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck. (PMID: 9694849) AntA^n I.M. … Geha R.S. (J. Biol. Chem. 1998) 3 23
  5. The rat homologue of Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation. (PMID: 11687573) Vetterkind S. … Preuss U. (J. Biol. Chem. 2002) 3 23

Products for WIPF1 Gene

  • Addgene plasmids for WIPF1

Sources for WIPF1 Gene

Back to Top

Content