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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WIPF1 Gene

protein-coding GIFtS: 59
GCID: GC02M175424

WAS/WASL interacting protein family, member 1

(Previous name: Wiskott-Aldrich syndrome protein interacting protein )
(Previous symbol: WASPIP)

Explore 5 diseases affiliated with
WIPF1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
WAS/WASL Interacting Protein Family, Member 1¹ ²		WASP-Interacting Protein² ³
WASPIP¹ ² ³		PRPL-2²
WIP¹ ² ³		WAS/WASL-Interacting Protein Family Member 1²
Wiskott-Aldrich Syndrome Protein Interacting Protein¹ ²		Wiskott-Aldrich Syndrome Protein-Interacting Protein³
Protein PRPL-2² ³

External Ids:	HGNC: 12736¹	Entrez Gene: 7456²	Ensembl: ENSG00000115935⁷	OMIM: 602357⁵	UniProtKB: O43516³

Export aliases for WIPF1 gene to outside databases

Previous GC identifers: GC02M175133 GC02M167305

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WIPF1:

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded

protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome,

an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the

disease. Two transcript variants encoding the same protein have been identified for this gene. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: WIPF1_HUMAN, O43516

Function: May have direct activity on the actin cytoskeleton. Induces actin polymerization and redistribution.

Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the

subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By

similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for

recruiting WASL to vaccinia virus

Gene Wiki entry for WIPF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WIPF1 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 POU2F2C AREB6 POU2F1 POU2F1a POU2F2B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WIPF1 promoter sequence

Search SABiosciences Chromatin IP Primers for WIPF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WIPF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.2

WIPF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WIPF1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M175424: view genomic region (about GC identifiers)

Start:	175,424,300 bp from pter	End:	175,547,644 bp from pter
Size:	123,345 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WIPF1_HUMAN, O43516 (See protein sequence)

Recommended Name: WAS/WASL-interacting protein family member 1

Size: 503 amino acids; 51258 Da

Subunit: Binds to WAS, profilin and actin. Binds to WASL (By similarity)

Subcellular location: Cytoplasmic vesicle (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Vesicle

surfaces and along actin tails. Co-localized with actin stress fibers. When co-expressed with WASL, no longer

associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity)

Miscellaneous: Recruited to PIP5K-induced vesicle surfaces in the absence of functional WASL (By similarity)

Sequence caution: Sequence=AAC03767.1; Type=Frameshift; Positions=302, 310; Sequence=CAA60014.1; Type=Frameshift;

Positions=302, 310;

1 PDB 3D structure from and Proteopedia for WIPF1:

2A41 (3D)

Secondary accessions: B8ZZM1 D3DPE4 Q15220 Q53TA9 Q6MZU9 Q9BU37 Q9UNP1

Alternative splicing: 4 isoforms: O43516-1 O43516-2 O43516-3 O43516-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WIPF1: NX_O43516

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43516

WIPF1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001070737.1 NP_003378.3

ENSEMBL proteins:

ENSP00000376330 ENSP00000272746 ENSP00000352802 ENSP00000376329 ENSP00000386431

ENSP00000387150 ENSP00000391785 ENSP00000386757 ENSP00000388454

Reactome Protein details: O43516
Human Recombinant Protein Products:

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	Uscn Proteins for WIPF1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005884	actin filament	IEA	--
GO:0015629	actin cytoskeleton	TAS	9405671
GO:0016023	cytoplasmic membrane-bounded vesicle	IEA	--

WIPF1 for ontologies About GeneDecksing

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	Uscn Antibodies for WIPF1
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	Uscn ELISAs and CLIAs for WIPF1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WIPF1 for domains About GeneDecksing

1 InterPro domain/family:

IPR003124 WH2_dom

Graphical View of Domain Structure for InterPro Entry O43516

ProtoNet protein and cluster: O43516

1 Blocks protein family: IPB003124 Actin-binding WH2

UniProtKB/Swiss-Prot: WIPF1_HUMAN, O43516

Domain: Binds to WAS within the N-terminal region 170, at a site distinct from the CDC42-binding site

Similarity: Belongs to the verprolin family

Similarity: Contains 1 WH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: WIPF1_HUMAN, O43516

Function: May have direct activity on the actin cytoskeleton. Induces actin polymerization and redistribution.

Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the

subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By

similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for

recruiting WASL to vaccinia virus

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WIPF1
		8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate WIPF1 (see all 68):
		hsa-miR-548j hsa-miR-607 hsa-miR-200a hsa-miR-632 hsa-miR-30d hsa-miR-30a hsa-miR-149 hsa-miR-29a*

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005522	profilin binding	TAS	9405671

WIPF1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for WIPF1:

Decreased viability of wild-ty

Animal Models:
Mouse knock-out Wipf1^tm1Geha for WIPF1
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Wipf1):

cellular

hematopoietic system

immune system

WIPF1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response CD16 signaling in NK cells

	Immune response CD16 signaling in NK cells	1.00			Immune response_Role of DAP12 receptors in NK cells	0.32
	Immune response_CD16 signaling in NK cells	0.99			Immune response Role of DAP12 receptors in NK cells	0.32

Regulation of actin dynamics for phagocytic cup formation

	Regulation of actin dynamics for phagocytic cup formation	1.00			Fcgamma receptor (FCGR) dependent phagocytosis	0.80
	Role of myosins in phagosome formation	0.80			Branching and elongation of mother and daughter filaments	0.29

Cytoskeleton remodeling_Reverse signaling by ephrin B

Cytoskeleton remodeling_Reverse signaling by ephrin B

1.00

Cytoskeleton remodeling Reverse signaling by ephrin B

0.94

Immune System

Immune System

1.00

Innate Immune System

0.46

Immune response Fc epsilon RI pathway

Fc-epsilon receptor I signaling in mast cells

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for WIPF1

	Immune response CD16 signaling in NK cells
	Immune response Role of DAP12 receptors in NK cells
	Cytoskeleton remodeling Reverse signaling by ephrin B

3 GeneGo (Thomson Reuters) Pathways for WIPF1

	Cytoskeleton remodeling Reverse signaling by ephrin B
	Immune response CD16 signaling in NK cells
	Immune response Role of DAP12 receptors in NK cells

1 BioSystems Pathway for WIPF1

Fc-epsilon receptor I signaling in mast cells

5/6 Reactome Pathways for WIPF1 (see all 6)

	Role of myosins in phagosome formation
	Branching and elongation of mother and daughter filaments
	Regulation of actin dynamics for phagocytic cup formation
	Fcgamma receptor (FCGR) dependent phagocytosis
	Immune System

WIPF1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for WIPF1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/88 Interacting proteins for WIPF1 (O43516^{1, 2, 3} ENSP00000352802⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 88)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WAS	P42768¹^,³, ENSP00000365891⁴	EBI-346356,EBI-346375 I2D: score=5 STRING: ENSP00000365891
HCK	P08631¹^,³, ENSP00000365012⁴	EBI-346356,EBI-346340 I2D: score=4 STRING: ENSP00000365012
WASL	O00401¹^,²^,³, ENSP00000223023⁴	EBI-346356,EBI-957615 MINT-2748661 I2D: score=4 STRING: ENSP00000223023
NCK1	P16333¹^,³, ENSP00000288986⁴	EBI-346356,EBI-3448658 I2D: score=4 STRING: ENSP00000288986
GRB2	P62993¹^,³, ENSP00000339007⁴	EBI-346356,EBI-401755 I2D: score=3 STRING: ENSP00000339007

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	TAS	9405671
GO:0008154	actin polymerization or depolymerization	TAS	9405671
GO:0030036	actin cytoskeleton organization	--	--
GO:0030048	actin filament-based movement	IEA	--
GO:0046827	positive regulation of protein export from nucleus	IEA	--

WIPF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

WIPF1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WIPF1
1 Novoseek chemical compound relationship for WIPF1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
proline	28.6	3	17207458 (1), 17711847 (1)

Search CenterWatch for drugs/clinical trials and news about WIPF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WIPF1 gene (2 alternative transcripts):

NM_001077269.1 NM_003387.4

Unigene Cluster for WIPF1:

WAS/WASL interacting protein family, member 1

Hs.128067 [show with all ESTs]

Unigene Representative Sequence: NM_001077269

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392547(uc002uiz.3 uc002uja.3) ENST00000272746(uc010fqt.1)

ENST00000359761 ENST00000392546 ENST00000409891(uc002ujb.2) ENST00000467149

ENST00000409415(uc010zep.1 uc002ujc.1) ENST00000455428 ENST00000410117

ENST00000436221 ENST00000480400 ENST00000470752 ENST00000474332 ENST00000488830

ENST00000490887 ENST00000469002 ENST00000487291

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		8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate WIPF1 (see all 68):
		hsa-miR-548j hsa-miR-607 hsa-miR-200a hsa-miR-632 hsa-miR-30d hsa-miR-30a hsa-miR-149 hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: WIPF1 3' UTR sequence

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Additional cDNA sequence:

AF031588.1 AF106062.1 AK097901.1 AK301271.1 AK304194.1 AL832275.1 BC002914.2 BC045584.1

BC110288.1 BX640870.1 X86019.1

23 DOTS entries:

DT.101954652 DT.91828690 DT.442605 DT.114796 DT.100732838 DT.91921572 DT.100807526 DT.95373991

DT.209121 DT.120933493 DT.100695642 DT.120933337 DT.91815916 DT.100716758 DT.100753872 DT.120933346

DT.120933439 DT.120933511 DT.120933518 DT.121639012 DT.95107131 DT.100644739 DT.120933489

24/321 AceView cDNA sequences (see all 321):

AA926898 AL706234 BX097182 AW771053 AA459777 H89086 AA279159 AA767669

CF528452 AI005043 BU177646 AA419190 AI569415 CR618785 AW086445 AA599214

AW136073 AW574751 AA455802 AA456622 AI889670 AI270255 AA810975 BU153081

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WIPF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTATGTAA

About this image

WIPF1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Dorsal Muscles

Mononuclear Myocytes

Skeletal Muscle

Limb

Forelimb Ventral Muscles

Mononuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Dorsal Muscle

Mononuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Ventral Muscle

Mononuclear Myocytes

Skeletal Muscle

Thoracic Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Hypaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Primary Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Primary Hypaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Lumbar Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See WIPF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WIPF1

SOURCE GeneReport for Unigene cluster: Hs.128067

UniProtKB/Swiss-Prot: WIPF1_HUMAN, O43516

Tissue specificity: Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon

and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and

testis

SABiosciences Expression via Pathway-Focused PCR Array including WIPF1:

Cell Motility in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIPF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for WIPF1 gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	WIPF1¹	WAS/WASL interacting protein family, member 1	69.38(n) 74.54(a)		424143 NM_001012917.1 NP_001012935.1
lizard (Anolis carolinensis)	Reptilia	WIPF1⁶	--	70(a)	1 ↔ 1	GL343377.1(840762-871410)
zebrafish (Danio rerio)	Actinopterygii	LOC100151491¹	uncharacterized LOC100151491	57.82(n) 61.89(a)		100151491 XM_001919831.3 XP_001919866.1
fruit fly (Drosophila melanogaster)	Insecta	CG15635⁶ CG11345⁶ (see all 5)	--	5(a) 17(a) (see all 5)	possible ortholog possible ortholog (see all 5)	2L(4642972-4646562) 3L(4457177-4458163)
worm (Caenorhabditis elegans)	Secernentea	sydn-1⁶	Protein SYDN-1	9(a)	possible ortholog	I(2377091-2381853)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	VRP1¹	Vrp1p	44.95(n) 41.05(a)		851051 NP_013441.1
thale cress (Arabidopsis thaliana)	eudicotyledons	ATEPR1⁶ AT4G08380⁶ (see all 23)	Proline-rich extensin-like family protein (see all 23)	9(a) 9(a) (see all 23)	possible ortholog possible ortholog (see all 23)	2(11713411-11715696) 4(5311093-5312406)
rice (Oryza sativa)	Liliopsida	-- --	basic proline-rich protein precursor, putative, ex... POEI32 - Pollen Ole e I allergen and extensin fami...	14(a) 12(a)	possible ortholog possible ortholog	11(2928563-2929760) 1(39135894-39138337)

ENSEMBL Gene Tree for WIPF1 (if available)
TreeFam Gene Tree for WIPF1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WIPF1 gene

WIPF3² WIPF2²

2 SIMAP similar genes for WIPF1 using alignment to 6 protein entries: WIPF1_HUMAN (see all proteins):

WASPIP WIPF2

WIPF1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112346166^1,2		--	167304763(+)	`CTCACA/CTTATA`	2	--	ds500¹		1	CSA	1
rs11482^1,2	C,F,	--	167305377(-)	`ACCGTA/CGAGGA`	2	--	ut3¹		8	MN NA CSA WA EA	686
rs2358888^1,2	C,F,O,A,H,	--	167305747(+)	`GTTATA/TAAAAA`	2	--	ut3¹		12	MN NA NS EA WA	1106
rs114365772^1,2	C,F,	--	167305754(+)	`AAAAAC/TACACA`	2	--	ut3¹		1	WA	118
rs113707857^1,2	C,	--	167305880(+)	`AAAGGG/TTGTAG`	2	--	ut3¹		2	NA	122
rs10930680^1,2	C,F,H,	--	167306061(+)	`TTCTCT/GGAGTC`	2	--	ut3¹		8	NS EA CSA WA NA	661
rs15327^1,2	C,F,O,H,	--	167306564(+)	`AGTAAT/CACATG`	2	--	ut3¹ ese³		12	MN NA NS EA CSA WA	985
rs78627036^1,2	F	--	167306688(+)	`CTAAGG/TGGAAA`	2	--	ut3¹		1	NA	4
rs10930681^1,2	C,F,H,	--	167307310(+)	`TGCTGG/CGTCCT`	2	--	ut3¹ ese³		7	NS EA CSA WA	660
rs6732100^1,2	C,F,A,H,	--	167307672(+)	`TTTCTA/GTTGGA`	2	--	ut3¹ ese³		17	NS EA NA WA	2338

HapMap Linkage Disequilibrium report for WIPF1 (175424300 - 175547644 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for WIPF1
3 Indels: 40390 63237 12108
Human Gene Mutation Database (HGMD): WIPF1

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WIPF1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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WIPF1 for disorders About GeneDecksing

OMIM gene information: 602357 OMIM disorders: --

UniProtKB/Swiss-Prot: WIPF1_HUMAN, O43516

Defects in WIPF1 are the cause of Wiskott-Aldrich syndrome type 2 (WAS2) [MIM:614493]. WAS2 is an

immunodeficiency disorder characterized by eczema, thrombocytopenia, recurrent infections, defective T-cell

proliferation, and impaired natural killer cell function

5 diseases for WIPF1: About MalaCards

wiskott-aldrich syndrome thrombocytopenia vaccinia immunodeficiency

prostatitis

1 disease from the University of Copenhagen DISEASES database for WIPF1:

Wiskott-Aldrich syndrome

2 Novoseek disease relationships for WIPF1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	95.6	39	9694849 (2), 10706671 (2), 17205972 (2), 10358064 (2) (see all 23)
immunodeficiency	31.8	1	10358064 (1)

Export disorders for WIPF1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for WIPF1 gene, integrated from 9 sources (see all 78):
(articles sorted by number of sources associating them with WIPF1)

Utopia: connect your pdf to the dynamic
world of online information

WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. (PubMed id 9405671)^{1, 2, 3, 9} Ramesh N.... Geha R.S. (1997)
Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein. (PubMed id 10202051)^{1, 2, 9} Stewart D.M.... Nelson D.L. (1999)
A novel primary human immunodeficiency due to deficiency in the WASP- interacting protein WIP. (PubMed id 22231303)^{1, 2} Lanzi G.... Giliani S. (2012)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization. (PubMed id 10878810)^{1, 2} Moreau V.... Way M. (2000)
The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast. (PubMed id 10358064)^{1, 9} Vaduva G....Ramesh N. (1999)
The rat homologue of Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation. (PubMed id 11687573)^{1, 9} Vetterkind S....Preuss U. (2002)
WIP is essential for lytic granule polarization and NK cell cytotoxicity. (PubMed id 18258743)^{1, 9} Krzewski K....Strominger J.L. (2008)
Structure-function analysis of the WIP role in T cell receptor-stimulated NFAT activation: evidence that WIP-WASP dissociation is not required and that the WIP NH2 terminus is inhibitory. (PubMed id 17711847)^{1, 9} Dong X....Shaw S. (2007)
WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP). (PubMed id 17213309)^{1, 9} de la Fuente M.A....Ramesh N. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7456	HGNC: 12736	AceView: WASPIP	Ensembl:ENSG00000115935	euGenes: HUgn7456
ECgene: WIPF1	H-InvDB: WIPF1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for WIPF1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WIPF1 gene
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Patent Information for WIPF1 gene:
Search GeneIP for patents involving WIPF1

GeneCards and IP:
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WAS/WASL interacting protein family, member 1

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WAS/WASL interacting protein family, member 1

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