External Ids for WIF1 Gene
Previous GeneCards Identifiers for WIF1 Gene
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]
GeneCards Summary for WIF1 Gene
WIF1 (WNT Inhibitory Factor 1) is a Protein Coding gene. Diseases associated with WIF1 include esophageal basaloid squamous cell carcinoma and colorectal cancer. Among its related pathways are Signaling by GPCR and Presenilin action in Notch and Wnt signaling. An important paralog of this gene is VWDE.
UniProtKB/Swiss-Prot for WIF1 Gene
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.