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WIF1 Gene

protein-coding   GIFtS: 62
GCID: GC12M065444

WNT Inhibitory Factor 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WNT Inhibitory Factor 11 2
WIF-12 3

External Ids:    HGNC: 180811   Entrez Gene: 111972   Ensembl: ENSG000001560767   OMIM: 6051865   UniProtKB: Q9Y5W53   

Export aliases for WIF1 gene to outside databases

Previous GC identifers: GC12P064885 GC12P065390 GC12M065161 GC12M063730 GC12M062496


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WIF1 Gene:
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules
that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five
epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene
functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers.
(provided by RefSeq, Jun 2010)

GeneCards Summary for WIF1 Gene:
WIF1 (WNT inhibitory factor 1) is a protein-coding gene. An important paralog of this gene is TENM2.

UniProtKB/Swiss-Prot: WIF1_HUMAN, Q9Y5W5
Function: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation

Gene Wiki entry for WIF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the WIF1 gene promoter:
         STAT5B   LHX3b/Lhx3b   AML1a   FOXD3   C/EBPalpha   POU2F1   POU2F1a   Chx10   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWIF1 promoter sequence
   Search Chromatin IP Primers for WIF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WIF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.3   Ensembl cytogenetic band:  12q14.3   HGNC cytogenetic band: 12q14.2

WIF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WIF1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M065444:  view genomic region     (about GC identifiers)

Start:
65,444,404 bp from pter      End:
65,515,346 bp from pter
Size:
70,943 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WIF1_HUMAN, Q9Y5W5 (See protein sequence)
Recommended Name: Wnt inhibitory factor 1 precursor  
Size: 379 amino acids; 41528 Da
5 PDB 3D structures from and Proteopedia for WIF1:
2D3J (3D)        2YGN (3D)        2YGO (3D)        2YGP (3D)        2YGQ (3D)    
Secondary accessions: Q6UXI1 Q8WVG4

Explore the universe of human proteins at neXtProt for WIF1: NX_Q9Y5W5

Explore proteomics data for WIF1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn88, Asn245

  • See WIF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009122.2  
    ENSEMBL proteins: 
     ENSP00000286574   ENSP00000439024   ENSP00000442063  
    Reactome Protein details: Q9Y5W5

    WIF1 Human Recombinant Protein Products:

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    antibodies-online proteins for WIF1 (23 products) 

     
    antibodies-online peptides for WIF1

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    WIF1 Assay Products:

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    antibodies-online kits for WIF1 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR013309 Wnt-inh
     IPR003306 WIF
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y5W5

    ProtoNet protein and cluster: Q9Y5W5

    2 Blocks protein domains:
    IPB003306 WIF domain
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: WIF1_HUMAN, Q9Y5W5
    Similarity: Contains 5 EGF-like domains
    Similarity: Contains 1 WIF domain


    Find genes that share domains with WIF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WIF1_HUMAN, Q9Y5W5
    Function: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19188438
         
    Find genes that share ontologies with WIF1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Wif1):
     mortality/aging  tumorigenesis 

    Find genes that share phenotypes with WIF1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WIF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target WIF1:
    hsa-mir-335-5p (MIRT017148)

    Block miRNA regulation of human, mouse, rat WIF1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate WIF1:
    hsa-miR-3163 hsa-miR-137 hsa-miR-485-3p hsa-miR-548v hsa-miR-3074-3p hsa-miR-656 hsa-miR-338-5p hsa-miR-127-5p
    SwitchGear 3'UTR luciferase reporter plasmidWIF1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WIF1
    Predesigned siRNA for gene silencing in human, mouse, rat WIF1

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    GenScript: all cDNA clones in your preferred vector: WIF1 (NM_007191)
    Sino Biological Human cDNA Clone for WIF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WIF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WIF1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WIF1_HUMAN, Q9Y5W5: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with WIF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WIF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    2Wnt signaling network
    Wnt signaling network
    3WNT Signaling
    WNT Signaling
    4Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    5Presenilin action in Notch and Wnt signaling
    Presenilin action in Notch and Wnt signaling


    Find genes that share SuperPaths with WIF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for WIF1
        WNT Signaling

    1 Cell Signaling Technology (CST) Pathway for WIF1
        Wnt / Hedgehog / Notch

    2 BioSystems Pathways for WIF1
        Wnt signaling network
    Presenilin action in Notch and Wnt signaling


    1 Reactome Pathway for WIF1
        negative regulation of TCF-dependent signaling by WNT ligand antagonists


    1 Kegg Pathway  (Kegg details for WIF1):
        Wnt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WIF1: 
              Lung Cancer in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for WIF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WIF1 (Q9Y5W51, 2, 3 ENSP000002865744) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT1P046283, ENSP000002935494I2D: score=1 STRING: ENSP00000293549
    DHHO433233, ENSP000002669914I2D: score=1 STRING: ENSP00000266991
    WNT11O960142, ENSP000003255264MINT-8389852 STRING: ENSP00000325526
    WNT7AO007552, ENSP000002850184MINT-8389828 STRING: ENSP00000285018
    FZD1ENSP000002879344STRING: ENSP00000287934
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS10201374
    GO:0007275multicellular organismal development IEA--
    GO:0016055Wnt signaling pathway IEA--
    GO:0045600positive regulation of fat cell differentiation IEA--

    Find genes that share ontologies with WIF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WIF1

    1 Novoseek inferred chemical compound relationship for WIF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 69.9 10 16007117 (2), 15256437 (1), 16501252 (1), 17384664 (1) (see all 5)



    Find genes that share compounds with WIF1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WIF1 gene: 
    NM_007191.4  

    Unigene Cluster for WIF1:

    WNT inhibitory factor 1
    Hs.284122  [show with all ESTs]
    Unigene Representative Sequence: NM_007191
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286574(uc001ssk.3) ENST00000543094 ENST00000546001
    miRNA
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    Block miRNA regulation of human, mouse, rat WIF1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate WIF1:
    hsa-miR-3163 hsa-miR-137 hsa-miR-485-3p hsa-miR-548v hsa-miR-3074-3p hsa-miR-656 hsa-miR-338-5p hsa-miR-127-5p
    SwitchGear 3'UTR luciferase reporter plasmidWIF1 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WIF1
      QuantiTect SYBR Green Assays in human, mouse, rat WIF1
      QuantiFast Probe-based Assays in human, mouse, rat WIF1

    Additional mRNA sequence: 

    AF122922.1 AK301818.1 AY358344.1 BC018037.1 BX647427.1 EU263622.1 

    6 DOTS entries:

    DT.412846  DT.95245312  DT.95174420  DT.95174424  DT.95174426  DT.100811772 

    Selected AceView cDNA sequences (see all 107):

    BM972094 BQ640145 AW269932 BX647427 BG539809 BM709548 AA905071 H83295 
    AL711431 CA444558 AI049799 CA397968 AI083491 AL711407 AI273588 CA425204 
    AI393483 AW118125 CD679205 BM693089 BU733763 AA904910 BX487390 AL711835 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WIF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WIF1 Expression
    About this image


    WIF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Stem Bronchi
             Alveolar type II cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
             Chondrocyte-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Progress Zone Cells Limb Bud
             Chondrocyte-like cells
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Progress Zone Cells Limb Bud
             Limb Bud
    WIF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WIF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.284122
        Pathway & Disease-focused RT2 Profiler PCR Arrays including WIF1: 
              Lung Cancer in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WIF1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wif11 , 5 Wnt inhibitory factor 11, 5 88.48(n)1
    93.93(a)1
      10 (68.98 cM)5
    241171  NM_011915.21  NP_036045.11 
     1210339605 
    chicken
    (Gallus gallus)
    Aves WIF11 WNT inhibitory factor 1 77.81(n)
    83.15(a)
      417831  NM_001199607.1  NP_001186536.1 
    lizard
    (Anolis carolinensis)
    Reptilia WIF16
    WNT inhibitory factor 1
    88(a)
    1 ↔ 1
    5(50156701-50210806)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4802 Xenopus laevis Wnt inhibitory factor-1 (WIF-1) mRNA, more 78.64(n)    AF122924.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wif12 wnt inhibitory factor-1 76.76(n)   30476  AF122925.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG31353
    shf1
    shifted1 33(a)3
    47.79(n)1
    37.09(a)1
      6C133
    316171  NM_132121.21  NP_572349.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T01D3.16
    Protein T01D3.1, isoform b
    3(a)
    1 → many
    V(13689892-13703326) WBGene00011326


    ENSEMBL Gene Tree for WIF1 (if available)
    TreeFam Gene Tree for WIF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WIF1 gene
    TENM22  TENM12  TENM42  TENM32  VWDE2  
    3 SIMAP similar genes for WIF1 using alignment to 3 protein entries:     WIF1_HUMAN (see all proteins):
    HMGA2/WIF1 fusion    JAG1    VWDE

    Find genes that share paralogs with WIF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WIF1 (see all 1272)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1439598751,2
    --65443935(+) AATGGC/TATAAT 1 -- ds50010--------
    rs65815981,2
    C,F--65443936(+) ATGGCG/ATAATG 1 -- ds500116Minor allele frequency- A:0.01NA WA CSA EA 517
    rs10356311,2
    C,F,A,H--65443998(-) ACAGCC/TCTATC 1 -- ds500131Minor allele frequency- T:0.50NA PA NS EA WA CSA 2743
    rs757346951,2
    C--65444262(+) GGGAGG/TGAGGG 1 -- ds50010--------
    rs1859075211,2
    --65444323(+) TTTATA/CCTGGA 1 -- ds50010--------
    rs1134275631,2
    F--65444356(+) CAACCC/AATTTT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs733293661,2
    C--65444632(+) TAATGG/CTAAGG 1 -- ut311Minor allele frequency- C:0.50WA 2
    rs1434073701,2
    --65444701(+) ACATCC/TAAATA 1 -- ut310--------
    rs1842192481,2
    --65444717(+) CAATAA/CAATCT 1 -- ut310--------
    rs1139972111,2
    C,F--65444835(+) TGCATT/AGTAAT 1 -- ut311Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for WIF1 (65444404 - 65515346 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WIF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270577CNV Insertion20981092
    nsv510299CNV Loss20534489
    nsv469458CNV Gain19166990
    nsv832445CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605186    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for WIF1:
    Cancer

    Find genes that share disorders with WIF1           About GenesLikeMe

    8 Novoseek inferred disease relationships for WIF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal tumors 42 2 17183069 (1)
    cancer 37.6 24 16007117 (5), 19885602 (2), 15351726 (2), 15256437 (1) (see all 7)
    tumors 31.4 42 17384664 (6), 19887605 (4), 16501252 (3), 18079202 (3) (see all 12)
    colorectal cancer 28.8 3 16007117 (1), 15735684 (1)
    adenoma 22.7 1 16007117 (1)
    osteosarcoma 20.9 3 19348043 (1), 19307728 (1)
    cancer lung 19.3 8 15256437 (3), 19885602 (2), 19528461 (1), 15351726 (1)
    colon cancer 9.52 4 16007117 (1), 16491118 (1)

    Genetic Association Database (GAD): WIF1
    Human Genome Epidemiology (HuGE) Navigator: WIF1 (6 documents)

    Export disorders for WIF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WIF1 gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with WIF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new secreted protein that binds to Wnt proteins and inhibits their activities. (PubMed id 10201374)1, 2, 3 Hsieh J.-C.... Nathans J. (Nature 1999)
    2. NMR structure of the WIF domain of the human Wnt-inhibitory factor- 1. (PubMed id 16476441)1, 2, 9 Liepinsh E.... Otting G. (J. Mol. Biol. 2006)
    3. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PubMed id 19926868)1, 4, 9 Sharma S....Weiss S.T. (Am. J. Respir. Crit. Care Med. 2010)
    4. Common variants at 12q14 and 12q24 are associated with hippocampal volume. (PubMed id 22504421)1, 4 Bis J.C....Seshadri S. (Nat. Genet. 2012)
    5. Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (PLoS ONE 2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (Psychiatry Res 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    10. Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. (PubMed id 16007117)1, 9 Taniguchi H....Shinomura Y. (Oncogene 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11197 HGNC: 18081 AceView: WIF1 Ensembl:ENSG00000156076 euGenes: HUgn11197
    ECgene: WIF1 Kegg: 11197 H-InvDB: WIF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WIF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WIF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WIF1 gene:
    Search GeneIP for patents involving WIF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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