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Aliases for WIF1 Gene

Aliases for WIF1 Gene

  • WNT Inhibitory Factor 1 2 3 5
  • WIF-1 3 4

External Ids for WIF1 Gene

Previous GeneCards Identifiers for WIF1 Gene

  • GC12P064885
  • GC12P065390
  • GC12M065161
  • GC12M063730
  • GC12M065444
  • GC12M062496

Summaries for WIF1 Gene

Entrez Gene Summary for WIF1 Gene

  • The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]

GeneCards Summary for WIF1 Gene

WIF1 (WNT Inhibitory Factor 1) is a Protein Coding gene. Diseases associated with WIF1 include Salivary Gland Adenoid Cystic Carcinoma and Esophageal Basaloid Squamous Cell Carcinoma. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways and Presenilin action in Notch and Wnt signaling. An important paralog of this gene is VWDE.

UniProtKB/Swiss-Prot for WIF1 Gene

  • Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

Gene Wiki entry for WIF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIF1 Gene

Genomics for WIF1 Gene

Regulatory Elements for WIF1 Gene

Enhancers for WIF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around WIF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for WIF1 Gene

Chromosome:
12
Start:
65,050,624 bp from pter
End:
65,121,566 bp from pter
Size:
70,943 bases
Orientation:
Minus strand

Genomic View for WIF1 Gene

Genes around WIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIF1 Gene

Proteins for WIF1 Gene

  • Protein details for WIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5W5-WIF1_HUMAN
    Recommended name:
    Wnt inhibitory factor 1
    Protein Accession:
    Q9Y5W5
    Secondary Accessions:
    • Q6UXI1
    • Q8WVG4

    Protein attributes for WIF1 Gene

    Size:
    379 amino acids
    Molecular mass:
    41528 Da
    Quaternary structure:
    • Interacts with MYOC.

    Three dimensional structures from OCA and Proteopedia for WIF1 Gene

neXtProt entry for WIF1 Gene

Post-translational modifications for WIF1 Gene

  • Glycosylation at Asn 88 and Asn 245
  • Modification sites at PhosphoSitePlus

Other Protein References for WIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WIF1 Gene

Domains & Families for WIF1 Gene

Protein Domains for WIF1 Gene

Suggested Antigen Peptide Sequences for WIF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5W5

UniProtKB/Swiss-Prot:

WIF1_HUMAN :
  • Contains 5 EGF-like domains.
Domain:
  • Contains 5 EGF-like domains.
  • Contains 1 WIF domain.
genes like me logo Genes that share domains with WIF1: view

No data available for Gene Families for WIF1 Gene

Function for WIF1 Gene

Molecular function for WIF1 Gene

UniProtKB/Swiss-Prot Function:
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

Gene Ontology (GO) - Molecular Function for WIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19188438
GO:0017147 Wnt-protein binding NAS 24431302
genes like me logo Genes that share ontologies with WIF1: view
genes like me logo Genes that share phenotypes with WIF1: view

Animal Models for WIF1 Gene

MGI Knock Outs for WIF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for WIF1

CRISPR Products

miRNA for WIF1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WIF1 Gene

Localization for WIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIF1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WIF1 Gene COMPARTMENTS Subcellular localization image for WIF1 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for WIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WIF1: view

Pathways & Interactions for WIF1 Gene

genes like me logo Genes that share pathways with WIF1: view

Pathways by source for WIF1 Gene

1 KEGG pathway for WIF1 Gene
1 Qiagen pathway for WIF1 Gene

SIGNOR curated interactions for WIF1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for WIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 10201374
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway NAS 24431302
GO:0045600 positive regulation of fat cell differentiation IEA --
genes like me logo Genes that share ontologies with WIF1: view

Drugs & Compounds for WIF1 Gene

(2) Drugs for WIF1 Gene - From: PharmGKB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Platinum compounds Pharma 0
KY 02111 Pharma WNT signaling inhibitor 0

(1) Additional Compounds for WIF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for WIF1 Gene

Compound Action Cas Number
KY 02111 WNT signaling inhibitor 1118807-13-8
genes like me logo Genes that share compounds with WIF1: view

Transcripts for WIF1 Gene

mRNA/cDNA for WIF1 Gene

Unigene Clusters for WIF1 Gene

WNT inhibitory factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WIF1 Gene

No ASD Table

Relevant External Links for WIF1 Gene

GeneLoc Exon Structure for
WIF1
ECgene alternative splicing isoforms for
WIF1

Expression for WIF1 Gene

mRNA expression in normal human tissues for WIF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WIF1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.9), Brain - Caudate (basal ganglia) (x8.7), Brain - Putamen (basal ganglia) (x7.1), and Brain - Amygdala (x6.3).

Protein differential expression in normal tissues from HIPED for WIF1 Gene

This gene is overexpressed in Vitreous humor (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WIF1 Gene



Protein tissue co-expression partners for WIF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WIF1 Gene:

WIF1

SOURCE GeneReport for Unigene cluster for WIF1 Gene:

Hs.284122
genes like me logo Genes that share expression patterns with WIF1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for WIF1 Gene

Orthologs for WIF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for WIF1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia WIF1 34
  • 91.82 (n)
  • 94.72 (a)
WIF1 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wif1 34
  • 88.48 (n)
  • 93.93 (a)
Wif1 16
Wif1 35
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WIF1 34
  • 99.56 (n)
  • 99.47 (a)
WIF1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wif1 34
  • 89.5 (n)
  • 92.33 (a)
cow
(Bos Taurus)
Mammalia WIF1 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WIF1 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WIF1 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves WIF1 34
  • 77.81 (n)
  • 83.15 (a)
WIF1 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WIF1 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5672 34
wif1 34
  • 78.02 (n)
  • 84.89 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.480 34
zebrafish
(Danio rerio)
Actinopterygii wif1 34
  • 68.72 (n)
  • 70.86 (a)
wif1 35
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3135 36
  • 33 (a)
shf 34
  • 47.79 (n)
  • 37.09 (a)
shf 35
  • 25 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000117 34
  • 47.37 (n)
  • 40.91 (a)
worm
(Caenorhabditis elegans)
Secernentea T01D3.1 35
  • 3 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 2 (a)
ManyToMany
-- 35
  • 15 (a)
ManyToMany
-- 35
  • 3 (a)
ManyToMany
Species where no ortholog for WIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WIF1 Gene

ENSEMBL:
Gene Tree for WIF1 (if available)
TreeFam:
Gene Tree for WIF1 (if available)

Paralogs for WIF1 Gene

Paralogs for WIF1 Gene

(3) SIMAP similar genes for WIF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WIF1: view

Variants for WIF1 Gene

Sequence variations from dbSNP and Humsavar for WIF1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7301320 -- 65,120,486(+) TGTTG(C/T)GCTTT reference, synonymous-codon
rs7305974 -- 65,056,677(+) tggaa(C/T)cttgc intron-variant
rs7306391 -- 65,093,755(+) GTTCC(C/T)GCATG intron-variant
rs7306519 -- 65,093,897(+) CTCTT(C/T)TAACA intron-variant
rs7308550 -- 65,076,284(+) ctccc(A/C)cctcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WIF1 Gene

Variant ID Type Subtype PubMed ID
esv3306300 CNV mobile element insertion 20981092
esv3389043 CNV insertion 20981092
esv3629788 CNV loss 21293372
nsv1053931 CNV gain 25217958
nsv469458 CNV gain 19166990
nsv510299 OTHER sequence alteration 20534489
nsv559205 CNV gain 21841781
nsv832445 CNV gain 17160897

Variation tolerance for WIF1 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WIF1 Gene

Human Gene Mutation Database (HGMD)
WIF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WIF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIF1 Gene

Disorders for WIF1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for WIF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
salivary gland adenoid cystic carcinoma
  • adenoid cystic cancer
esophageal basaloid squamous cell carcinoma
  • basaloid squamous carcinoma of esophagus
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search WIF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WIF1

Genetic Association Database (GAD)
WIF1
Human Genome Epidemiology (HuGE) Navigator
WIF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WIF1
genes like me logo Genes that share disorders with WIF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WIF1 Gene

Publications for WIF1 Gene

  1. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. (PMID: 19926868) Sharma S. … Weiss S.T. (Am. J. Respir. Crit. Care Med. 2010) 3 22 46 65
  2. NMR structure of the WIF domain of the human Wnt-inhibitory factor- 1. (PMID: 16476441) Liepinsh E. … Otting G. (J. Mol. Biol. 2006) 3 4 22 65
  3. A new secreted protein that binds to Wnt proteins and inhibits their activities. (PMID: 10201374) Hsieh J.-C. … Nathans J. (Nature 1999) 2 3 4 65
  4. Common variants at 12q14 and 12q24 are associated with hippocampal volume. (PMID: 22504421) Bis J.C. … Seshadri S. (Nat. Genet. 2012) 3 46 65
  5. Expression and aberrant promoter methylation of Wnt inhibitory factor-1 in human astrocytomas. (PMID: 20334650) Yang Z. … Wang Y. (J. Exp. Clin. Cancer Res. 2010) 3 22 65

Products for WIF1 Gene

Sources for WIF1 Gene

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