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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WIBG Gene

protein-coding   GIFtS: 53
GCID: GC12M056295

within bgcn homolog (Drosophila)

 Explore 11 diseases affiliated with
WIBG via our new
 Human Malady Compendium 
Biological research products
for WIBG
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Within Bgcn Homolog (Drosophila)1 2
PYM1 2 3
Protein Wibg Homolog2 3
Partner Of Y14 And Mago2

External Ids:    HGNC: 302581   Entrez Gene: 843052   Ensembl: ENSG000001704737   UniProtKB: Q9BRP83   

Export aliases for WIBG gene to outside databases

Previous GC identifers: GC12M054582 GC12M053334


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: WIBG_HUMAN, Q9BRP8
Function: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream
of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and
directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or
translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting
mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a
translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been
translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May
bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while
PubMed:19410547 did not detect RNA-binding activity independently of the EJC




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WIBG gene promoter:
         AREB6   Egr-2   p53   c-Myb   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWIBG promoter sequence
   Search SABiosciences Chromatin IP Primers for WIBG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WIBG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

WIBG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WIBG gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056295:  view genomic region     (about GC identifiers)

Start:
56,295,197 bp from pter      End:
56,326,402 bp from pter
Size:
31,206 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WIBG_HUMAN, Q9BRP8 (See protein sequence)
Recommended Name: Partner of Y14 and mago  
Size: 204 amino acids; 22656 Da
Subunit: Interacts (via N-terminus) with MAGOH and RBM8A; the interaction is direct. Associates (eIF2A-like region)
with the 40S ribosomal subunit and the 48S preinitiation complex
Subcellular location: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and the
cytoplasm. Nuclear export is mediated by XPO1/CRM1
Secondary accessions: B6ZDM5 Q8IXJ8 Q8N8E7
Alternative splicing: 2 isoforms:  Q9BRP8-1   Q9BRP8-2   

Explore the universe of human proteins at neXtProt for WIBG: NX_Q9BRP8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BRP8

  • WIBG Protein expression data from MOPED and PaxDb:    About this image 
    WIBG Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137325.1  NP_115721.1  

    ENSEMBL proteins: 
     ENSP00000386156   ENSP00000381271   ENSP00000452447   ENSP00000448858   ENSP00000452291  
     ENSP00000402829  

    Human Recombinant Protein Products for WIBG: 
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    Novus Biologicals WIBG Proteins
    Novus Biologicals WIBG Lysate
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    ProSpec Recombinant Protein for WIBG
    Uscn Proteins for WIBG

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--
    GO:0035145exon-exon junction complex IDA18026120

    WIBG for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    WIBG for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR015362 EJC_Pym

    Graphical View of Domain Structure for InterPro Entry Q9BRP8

    ProtoNet protein and cluster: Q9BRP8

    UniProtKB/Swiss-Prot: WIBG_HUMAN, Q9BRP8
    Domain: The eIF2A-like region shares sequence similarity with eIF2A and mediates the interaction with the 40S ribosomal
    subunit and the 48S preinitiation complex
    Similarity: Belongs to the wibg family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WIBG_HUMAN, Q9BRP8
    Function: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream
    of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and
    directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or
    translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting
    mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a
    translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been
    translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May
    bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while
    PubMed:19410547 did not detect RNA-binding activity independently of the EJC

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI19410547
    GO:0043022ribosome binding IDA18026120
         
    WIBG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WIBG:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for WIBG 

    miRNA
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    miRTarBase miRNAs that target WIBG:
    hsa-mir-21 (MIRT000163)

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    hsa-miR-4291 hsa-miR-15a hsa-miR-1260b hsa-miR-200a hsa-miR-141 hsa-miR-424 hsa-miR-375 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidWIBG 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIBG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA surveillance pathway
    mRNA surveillance pathway1.00
    2RNA transport
    RNA transport1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for WIBG):
        RNA transport
    mRNA surveillance pathway


    WIBG for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WIBG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/18 Interacting proteins for WIBG (Q9BRP81, 2, 3 ENSP000003861564) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL23P628291, 3, ENSP000003778654EBI-2352802,EBI-353303 I2D: score=1 STRING: ENSP00000377865
    PRNPP041561, 3EBI-2352802,EBI-977302 I2D: score=1 
    MAGOHP613263, ENSP000003605254I2D: score=1 STRING: ENSP00000360525
    RBM8AQ9Y5S93, ENSP000003330014I2D: score=1 STRING: ENSP00000333001
    RPS6P627533, ENSP000003697574I2D: score=1 STRING: ENSP00000369757
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA19410547
    GO:0045727positive regulation of translation IDA18026120

    WIBG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WIBG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WIBG
    5 Novoseek chemical compound relationships for WIBG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pingyangmycin 97.7 161 11596291 (11), 17241428 (8), 9692057 (7), 18359702 (5) (see all 17)
    teniposide 62.9 8 15196390 (3), 12641948 (1)
    psoralen 52.9 9 7540529 (4), 1304460 (1)
    cisplatin 22.7 11 15196390 (3), 12641948 (2), 15014812 (1)
    5fluorouracil 17.7 4 12641948 (2), 9642344 (1)

    Search CenterWatch for drugs/clinical trials and news about WIBG 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WIBG gene (2 alternative transcripts): 
    NM_001143853.1  NM_032345.2  

    Unigene Cluster for WIBG:

    Within bgcn homolog (Drosophila)
    Hs.505687  [show with all ESTs]
    Unigene Representative Sequence: NM_032345
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000408946(uc001sif.1) ENST00000398213(uc001sie.1) ENST00000302533
    ENST00000557259 ENST00000547925 ENST00000549939 ENST00000454792(uc001sig.3)


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    hsa-miR-4291 hsa-miR-15a hsa-miR-1260b hsa-miR-200a hsa-miR-141 hsa-miR-424 hsa-miR-375 hsa-miR-195
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    Additional cDNA sequence: 

    AJ459406.1 AK096922.1 BC006135.1 BC014976.1 

    9 DOTS entries:

    DT.113147  DT.91744921  DT.101977014  DT.100814993  DT.91848585  DT.100814995  DT.121208095  DT.121208031 
    DT.454708 

    24/130 AceView cDNA sequences (see all 130):

    AA832520 AA775589 BQ051512 BC009627 CF529060 BQ641947 CR606391 CR613330 
    BC008292 AI377416 BM982723 BE735569 CB160927 BC014976 AA814459 BE271741 
    C15655 BX417184 AA313504 AW297494 CB159392 BG773603 BI548852 CB143972 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for WIBG    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                                            -                                 
    SP2:              -     -     -     -     -     -                                 
    SP3:              -                                                               
    SP4:                    -     -     -     -     -                                 
    SP5:                                      -     -                                 


    ECgene alternative splicing isoforms for WIBG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WIBG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGCTGCCG
    WIBG Expression
    About this image
    See WIBG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WIBG

    SOURCE GeneReport for Unigene cluster: Hs.505687
        SABiosciences Custom PCR Arrays for WIBG

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WIBG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIBG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WIBG gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wibg1 , 5 within bgcn homolog (Drosophila)1, 5 86.47(n)1
    92.57(a)1
      10 (77.14 cM)5
    784281  NM_001170869.21  NP_001164340.11 
     1287478795 
    chicken
    (Gallus gallus)
    Aves LOC1008582401 partner of Y14 and mago-like 67.66(n)
    72.77(a)
      100858240  XM_003643452.1  XP_003643500.1 
    lizard
    (Anolis carolinensis)
    Reptilia WIBG6
    --
    61(a)
    1 ↔ 1
    GL343198.1(3211707-3218184)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.134842 Xenopus laevis transcribed sequence with weak similarity more 75.55(n)    CB199017.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658912 hypothetical protein MGC65891 78.48(n)   393566  BC056755.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wibg1 within bgcn 49.26(n)
    40(a)
      37780  NM_166627.2  NP_726372.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T20G5.96
    Protein T20G5.9
    30(a)
    1 ↔ 1
    III(10209747-10211006)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PYM1 partner of Y14-mago 46.47(n)
    37.65(a)
      837682  NM_101013.1  NP_563890.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02621001 hypothetical protein 50.58(n)
    43.02(a)
      4332324  NM_001056160.1  NP_001049625.1 


    ENSEMBL Gene Tree for WIBG (if available)
    TreeFam Gene Tree for WIBG (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WIBG gene
    EIF2A2  

    WIBG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/51 NCBI SNPs in WIBG are shown (see all 51    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs619564241,2
    C--56298115(+) GCTCAC/TGCCTA 1 -- int13Minor allele frequency- T:0.00NA CSA 5
    rs619564251,2
    C--56298120(+) TGCCTG/ATAATC 1 -- int13Minor allele frequency- A:0.00NA CSA 5
    rs1902700081,2
    --56298323(+) TGCAGC/TGGGCA 1 -- int10--------
    rs1497211901,2
    --56298350(+) ACTCCA/GGCCTG 1 -- int10--------
    rs714477661,2
    C--56298396(+) AAAAAG/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1444716531,2
    --56298466(+) GACCAG/TCCTGG 1 -- int10--------
    rs1484354731,2
    --56298551(+) AGCTAC/TTGGGG 1 -- int10--------
    rs770275421,2
    C,F--56298781(+) TATTTA/TTATTT 1 -- int12Minor allele frequency- T:0.17NA EA 240
    rs107837731,2
    C--56298824(+) TCTGTT/CGCCCA 1 -- int11Minor allele frequency- C:0.00NA 2
    rs1408297451,2
    --56298840(+) GAGTGC/GAGTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for WIBG (56295197 - 56326402 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for WIBG: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    WIBG for disorders           About GeneDecksing

    11 diseases for WIBG:    About MalaCards
    cavernous hemangioma    oral squamous cell carcinoma    squamous cell carcinoma    hemangioma
    tongue cancer    mucoepidermoid carcinoma    oral cancer    carcinoma
    lung cancer    prostate cancer    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for WIBG:
    Tongue cancer     Cavernous hemangioma     Squamous cell carcinoma

    6 Novoseek disease relationships for WIBG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 46.1 6 1706647 (2), 15196390 (1), 15014812 (1), 10745179 (1) (see all 5)
    cancer lung 15.8 2 1706647 (1), 12485505 (1)
    tumors 12.9 15 11596291 (3), 16288335 (2), 7540529 (1), 17241428 (1) (see all 5)
    cancer 2.22 4 8571778 (2), 18359702 (1), 1706647 (1)
    necrosis 0 2 10745179 (1), 17241428 (1)
    carcinoma 0 1 17241428 (1)


    Export disorders for WIBG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WIBG gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with WIBG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. (PubMed id 12438415)1, 2, 3 Gatfield D. and Izaurralde E. (2002)
    2. Disassembly of exon junction complexes by PYM. (PubMed id 19410547)1, 2, 9 Gehring N.H.... Hentze M.W. (2009)
    3. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. (PubMed id 18026120)1, 2, 9 Diem M.D.... Dreyfuss G. (2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. An efficient protein complex purification method for functional proteomics in higher eukaryotes. (PubMed id 12483225)1, 3 Forler D....Wilm M. (2003)
    6. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. (PubMed id 14968132)2, 9 Bono F....Conti E. (2004)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84305 HGNC: 30258 AceView: PYM Ensembl:ENSG00000170473 euGenes: HUgn84305
    ECgene: WIBG Kegg: 84305 H-InvDB: WIBG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WIBG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WIBG gene:
    Search GeneIP for patents involving WIBG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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