Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WIBG Gene

protein-coding   GIFtS: 55
GCID: GC12M056295

Within Bgcn Homolog (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Within Bgcn Homolog (Drosophila)1 2
Protein Wibg Homolog2 3
PYM2 3
Partner Of Y14 And Mago2

External Ids:    HGNC: 302581   Entrez Gene: 843052   Ensembl: ENSG000001704737   UniProtKB: Q9BRP83   

Export aliases for WIBG gene to outside databases

Previous GC identifers: GC12M054582 GC12M053334


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WIBG Gene: 
WIBG (within bgcn homolog (Drosophila)) is a protein-coding gene. Diseases associated with WIBG include mucoepidermoid carcinoma, and tongue cancer. GO annotations related to this gene include ribosome binding and RNA binding.

UniProtKB/Swiss-Prot: WIBG_HUMAN, Q9BRP8
Function: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately
upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of
genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA
decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and
recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably
prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to
mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by
antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was
detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WIBG gene promoter:
         AREB6   Egr-2   p53   c-Myb   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWIBG promoter sequence
   Search SABiosciences Chromatin IP Primers for WIBG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WIBG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

WIBG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WIBG gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056295:  view genomic region     (about GC identifiers)

Start:
56,295,197 bp from pter      End:
56,326,402 bp from pter
Size:
31,206 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WIBG_HUMAN, Q9BRP8 (See protein sequence)
Recommended Name: Partner of Y14 and mago  
Size: 204 amino acids; 22656 Da
Subunit: Interacts (via N-terminus) with MAGOH and RBM8A; the interaction is direct. Associates (eIF2A-like
region) with the 40S ribosomal subunit and the 48S preinitiation complex
Subcellular location: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and
the cytoplasm. Nuclear export is mediated by XPO1/CRM1
Secondary accessions: B6ZDM5 Q8IXJ8 Q8N8E7
Alternative splicing: 2 isoforms:  Q9BRP8-1   Q9BRP8-2   

Explore the universe of human proteins at neXtProt for WIBG: NX_Q9BRP8

Explore proteomics data for WIBG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BRP8

  • WIBG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WIBG Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137325.1  NP_115721.1  

    ENSEMBL proteins: 
     ENSP00000386156   ENSP00000381271   ENSP00000452447   ENSP00000448858   ENSP00000452291  
     ENSP00000402829  

    Human Recombinant Protein Products for WIBG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for WIBG
    OriGene Protein Over-expression Lysate for WIBG
    OriGene MassSpec for WIBG 
    OriGene Custom Protein Services for WIBG
    GenScript Custom Purified and Recombinant Proteins Services for WIBG
    Novus Biologicals WIBG Proteins
    Novus Biologicals WIBG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for WIBG
    Cloud-Clone Corp. Proteins for WIBG 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--
    GO:0035145exon-exon junction complex IDA18026120

    WIBG for ontologies           About GeneDecksing



    WIBG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of WIBG
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WIBG
    GenScript Custom Superior Antibodies Services for WIBG
    Novus Biologicals WIBG Antibodies
    Abcam antibodies for WIBG
    Cloud-Clone Corp. Antibodies for WIBG 
    ThermoFisher Antibodies for WIBG
    LSBio Antibodies in human, mouse, rat for WIBG 

    Assay Products for WIBG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WIBG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WIBG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WIBG 
    Cloud-Clone Corp. CLIAs for WIBG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR015362 EJC_Pym

    Graphical View of Domain Structure for InterPro Entry Q9BRP8

    ProtoNet protein and cluster: Q9BRP8

    UniProtKB/Swiss-Prot: WIBG_HUMAN, Q9BRP8
    Domain: The eIF2A-like region shares sequence similarity with eIF2A and mediates the interaction with the 40S
    ribosomal subunit and the 48S preinitiation complex
    Similarity: Belongs to the wibg family


    WIBG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WIBG_HUMAN, Q9BRP8
    Function: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately
    upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of
    genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA
    decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and
    recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably
    prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to
    mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by
    antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was
    detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI18026120
    GO:0043022ribosome binding IDA18026120
         
    WIBG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WIBG:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WIBG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WIBG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WIBG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WIBG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target WIBG:
    hsa-mir-21 (MIRT000163)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WIBG
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate WIBG (see all 19):
    hsa-miR-4291 hsa-miR-15a hsa-miR-1260b hsa-miR-200a hsa-miR-141 hsa-miR-424 hsa-miR-375 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidWIBG 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WIBG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WIBG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WIBG
    Sirion Biotech Customized adenovirus for overexpression of WIBG

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for WIBG (see all 14)
    OriGene ORF clones in mouse, rat for WIBG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WIBG (NM_032345)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WIBG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WIBG
    Sirion Biotech Customized lentivirus for stable overexpression of WIBG 
                         Customized lentivirus expression plasmids for stable overexpression of WIBG 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WIBG
    Search LifeMap BioReagents cell lines for WIBG
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIBG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WIBG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA surveillance pathway
    mRNA surveillance pathway
    2RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for WIBG):
        RNA transport
    mRNA surveillance pathway


    WIBG for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WIBG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/18 Interacting proteins for WIBG (Q9BRP81, 2, 3 ENSP000003861564) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL23P628291, 3, ENSP000003778654EBI-2352802,EBI-353303 I2D: score=1 STRING: ENSP00000377865
    PRNPP041561, 3EBI-2352802,EBI-977302 I2D: score=1 
    MAGOHP613263, ENSP000003605254I2D: score=1 STRING: ENSP00000360525
    RBM8AQ9Y5S93, ENSP000003330014I2D: score=1 STRING: ENSP00000333001
    RPS6P627533, ENSP000003697574I2D: score=1 STRING: ENSP00000369757
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA19410547
    GO:0045727positive regulation of translation IDA18026120

    WIBG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WIBG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WIBG

    5 Novoseek inferred chemical compound relationships for WIBG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pingyangmycin 97.7 161 11596291 (11), 17241428 (8), 9692057 (7), 18359702 (5) (see all 17)
    teniposide 62.9 8 15196390 (3), 12641948 (1)
    psoralen 52.9 9 7540529 (4), 1304460 (1)
    cisplatin 22.7 11 15196390 (3), 12641948 (2), 15014812 (1)
    5fluorouracil 17.7 4 12641948 (2), 9642344 (1)

    Search CenterWatch for drugs/clinical trials and news about WIBG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WIBG gene (2 alternative transcripts): 
    NM_001143853.1  NM_032345.2  

    Unigene Cluster for WIBG:

    Within bgcn homolog (Drosophila)
    Hs.505687  [show with all ESTs]
    Unigene Representative Sequence: NM_032345
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000408946(uc001sif.1) ENST00000398213(uc001sie.1) ENST00000302533
    ENST00000557259 ENST00000547925 ENST00000549939 ENST00000454792(uc001sig.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WIBG
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate WIBG (see all 19):
    hsa-miR-4291 hsa-miR-15a hsa-miR-1260b hsa-miR-200a hsa-miR-141 hsa-miR-424 hsa-miR-375 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidWIBG 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WIBG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WIBG
    Clone
    Products:
         
    OriGene clones in human, mouse for WIBG (see all 14)
    OriGene ORF clones in mouse, rat for WIBG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WIBG (NM_032345)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WIBG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WIBG
    Sirion Biotech Customized lentivirus for stable overexpression of WIBG 
                         Customized lentivirus expression plasmids for stable overexpression of WIBG 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WIBG
    OriGene qSTAR qPCR primer pairs in human, mouse for WIBG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WIBG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WIBG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WIBG

    Additional mRNA sequence: 

    AJ459406.1 AK096922.1 BC006135.1 BC014976.1 

    9 DOTS entries:

    DT.113147  DT.91744921  DT.101977014  DT.100814993  DT.91848585  DT.100814995  DT.121208095  DT.121208031 
    DT.454708 

    24/130 AceView cDNA sequences (see all 130):

    CR606391 BQ051512 CF529060 CR613330 BQ641947 AA775589 AA832520 BC009627 
    AW297494 CB159392 BF933156 BI548852 BG193328 C15655 AI377416 AI039473 
    BU741176 AI183518 AI004908 NM_032345 BM726891 AA342851 BC008292 CB143972 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for WIBG    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                                            -                                 
    SP2:              -     -     -     -     -     -                                 
    SP3:              -                                                               
    SP4:                    -     -     -     -     -                                 
    SP5:                                      -     -                                 


    ECgene alternative splicing isoforms for WIBG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WIBG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCTGCCG
    WIBG Expression
    About this image


    See WIBG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WIBG

    SOURCE GeneReport for Unigene cluster: Hs.505687
        SABiosciences Custom PCR Arrays for WIBG
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WIBG
    OriGene qSTAR qPCR primer pairs in human, mouse for WIBG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WIBG
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WIBG
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WIBG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIBG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WIBG gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wibg1 , 5 within bgcn homolog (Drosophila)1, 5 86.47(n)1
    92.57(a)1
      10 (77.14 cM)5
    784281  NM_001170869.21  NP_001164340.11 
     1287478795 
    chicken
    (Gallus gallus)
    Aves LOC1008582401 partner of Y14 and mago-like 67.66(n)
    72.77(a)
      100858240  XM_003643452.1  XP_003643500.1 
    lizard
    (Anolis carolinensis)
    Reptilia WIBG6
    Uncharacterized protein
    61(a)
    1 ↔ 1
    GL343198.1(3211707-3218184)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.134842 Xenopus laevis transcribed sequence with weak similarity more 75.55(n)    CB199017.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658912 hypothetical protein MGC65891 78.48(n)   393566  BC056755.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wibg1 within bgcn 49.26(n)
    40(a)
      37780  NM_166627.2  NP_726372.1 
    worm
    (Caenorhabditis elegans)
    Secernentea E04D5.16
    T20G5.96
    Protein T20G5.9
    7(a)
    29(a)
    possible ortholog
    1 ↔ 1
    II(10416786-10419418)
    III(10209838-10211097)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YGR054W6
    Eukaryotic initiation factor (eIF) 2A; associates ...
    6(a)
    1 → many
    VII(596693-598621)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PYM1 partner of Y14-mago 46.47(n)
    37.65(a)
      837682  NM_101013.1  NP_563890.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02621001 hypothetical protein 50.58(n)
    43.02(a)
      4332324  NM_001056160.1  NP_001049625.1 


    ENSEMBL Gene Tree for WIBG (if available)
    TreeFam Gene Tree for WIBG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/510 SNPs in WIBG are shown (see all 510)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151100071,2
    F--53333680(+) GAAACC/TGCGCC 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1886335341,2
    --53333690(+) CACTAA/CACTCC 2 -- int10--------
    rs111716951,2
    C,F--53333719(+) AGACTC/TCATCT 2 -- int14Minor allele frequency- T:0.21NA 126
    rs7724691,2
    C,H--53333767(-) gttacC/Tgtgcc 2 -- int113Minor allele frequency- T:0.05NA WA CSA EA 376
    rs1112409641,2
    F--53333858(+) ACATGG/ATGAAA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1489936801,2
    --53333898(+) GTGGTA/GGTGGG 2 -- int10--------
    rs1914909801,2
    C--53333925(+) TACTCA/GGGAGG 2 -- int10--------
    rs1836587421,2
    --53334062(+) CAATAC/TTTGTC 2 -- int10--------
    rs1437048021,2
    --53334097(+) CAATAC/TCTACT 2 -- int10--------
    rs31773371,2
    C--53334309(-) TAAAAG/AAAAAT 2 -- ut311Minor allele frequency- A:0.00MN 184

    HapMap Linkage Disequilibrium report for WIBG (56295197 - 56326402 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WIBG:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1266306CNV Insertion17803354
    nsv832424CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WIBG
    DNA2.0 Custom Variant and Variant Library Synthesis for WIBG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    11 diseases for WIBG:    About MalaCards
    mucoepidermoid carcinoma    tongue cancer    cavernous hemangioma    oral squamous cell carcinoma
    hemangioma    oral cancer    squamous cell carcinoma    lung cancer
    prostate cancer    endotheliitis    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for WIBG:
    Tongue cancer     Cavernous hemangioma     Squamous cell carcinoma

    WIBG for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for WIBG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 46.1 6 1706647 (2), 15196390 (1), 15014812 (1), 10745179 (1) (see all 5)
    cancer lung 15.8 2 1706647 (1), 12485505 (1)
    tumors 12.9 15 11596291 (3), 16288335 (2), 7540529 (1), 17241428 (1) (see all 5)
    cancer 2.22 4 8571778 (2), 18359702 (1), 1706647 (1)
    necrosis 0 2 10745179 (1), 17241428 (1)
    carcinoma 0 1 17241428 (1)


    Export disorders for WIBG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WIBG gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with WIBG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. (PubMed id 12438415)1, 2, 3 Gatfield D. and Izaurralde E. (2002)
    2. Disassembly of exon junction complexes by PYM. (PubMed id 19410547)1, 2, 9 Gehring N.H.... Hentze M.W. (2009)
    3. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. (PubMed id 18026120)1, 2, 9 Diem M.D.... Dreyfuss G. (2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. An efficient protein complex purification method for functional proteomics in higher eukaryotes. (PubMed id 12483225)1, 3 Forler D....Wilm M. (2003)
    6. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. (PubMed id 14968132)2, 9 Bono F....Conti E. (2004)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84305 HGNC: 30258 AceView: PYM Ensembl:ENSG00000170473 euGenes: HUgn84305
    ECgene: WIBG Kegg: 84305 H-InvDB: WIBG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WIBG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WIBG gene:
    Search GeneIP for patents involving WIBG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of WIBG
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for WIBG  
     OriGene qPCR primer pairs and template standards for WIBG   OriGene Protein Over-expression Lysate for WIBG  
     OriGene MassSpec something-or-other for WIBG   OriGene clones in human, mouse for WIBG  
     OriGene qSTAR qPCR primer pairs in human, mouse for WIBG   OriGene Purified Protein for WIBG  
     OriGene ORF clones in mouse, rat for WIBG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WIBG   OriGene Custom Protein Services for WIBG  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WIBG
     QIAGEN SeqTarget long-range PCR primers for resequencing WIBG
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WIBG
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WIBG
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WIBG
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WIBG
     GenScript Custom Purified and Recombinant Proteins Services for WIBG GenScript cDNA clones with any tag delivered in your preferred vector for WIBG
     GenScript Custom Assay Services for WIBG GenScript Custom Superior Antibodies Services for WIBG
     GenScript Custom overexpressing Cell Line Services for WIBG CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in WIBG promoter
     Search Chromatin IP Primers for WIBG
     RT2 qPCR Primer Assay in human, mouse, rat WIBG
     Search GNC Networks for WIBG
     SABiosciences Custom PCR Arrays for WIBG
     Search Tocris compounds for WIBG
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     WIBG antibodies
     WIBG proteins
     WIBG lysates
     Antibodies for WIBG
     See all of Abcam's Antibodies, Kits and Proteins for WIBG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for WIBG




     Proteins for WIBG
     Antibodies for WIBG
     ELISAs for WIBG
     CLIAs for WIBG
     Search LifeMap BioReagents cell lines for WIBG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIBG
     SwitchGear 3'UTR luciferase reporter plasmids for WIBG
     SwitchGear Promoter luciferase reporter plasmids for WIBG
     ThermoFisher Antibodies for WIBG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WIBG
     inGenious Targeting Laboratory - Custom generated mouse model solutions for WIBG
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WIBG
    Customized:
     lentivirus for stable overexpression of WIBG
     lentivirus expression plasmids for stable overexpression of WIBG
     adenovirus for overexpression of WIBG
     LSBio Antibodies in human, mouse, rat for WIBG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WIBG gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4