Aliases for WIBG Gene
External Ids for WIBG Gene
GeneCards Summary for WIBG Gene
WIBG (Within Bgcn Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with WIBG include mucoepidermoid carcinoma and cavernous hemangioma. Among its related pathways are RNA transport and mRNA surveillance pathway. GO annotations related to this gene include RNA binding and ribosome binding.
UniProtKB/Swiss-Prot for WIBG Gene
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.