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Aliases for WIBG Gene

Aliases for WIBG Gene

  • Within Bgcn Homolog (Drosophila) 2 3
  • Protein Wibg Homolog 3 4
  • PYM 3 4
  • Partner Of Y14 And Mago 3

External Ids for WIBG Gene

Summaries for WIBG Gene

GeneCards Summary for WIBG Gene

WIBG (Within Bgcn Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with WIBG include mucoepidermoid carcinoma and cavernous hemangioma. Among its related pathways are RNA transport and mRNA surveillance pathway. GO annotations related to this gene include RNA binding and ribosome binding.

UniProtKB/Swiss-Prot for WIBG Gene

  • Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WIBG Gene

Genomics for WIBG Gene

Genomic Location for WIBG Gene

Start:
55,901,413 bp from pter
End:
55,932,618 bp from pter
Size:
31,206 bases
Orientation:
Minus strand

Genomic View for WIBG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WIBG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WIBG Gene

Regulatory Elements for WIBG Gene

Proteins for WIBG Gene

  • Protein details for WIBG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRP8-WIBG_HUMAN
    Recommended name:
    Partner of Y14 and mago
    Protein Accession:
    Q9BRP8
    Secondary Accessions:
    • B6ZDM5
    • Q8IXJ8
    • Q8N8E7

    Protein attributes for WIBG Gene

    Size:
    204 amino acids
    Molecular mass:
    22656 Da
    Quaternary structure:
    • Interacts (via N-terminus) with MAGOH and RBM8A; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

    Alternative splice isoforms for WIBG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WIBG Gene

Proteomics data for WIBG Gene at MOPED

Post-translational modifications for WIBG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WIBG Gene

No data available for DME Specific Peptides for WIBG Gene

Domains for WIBG Gene

Protein Domains for WIBG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WIBG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRP8

UniProtKB/Swiss-Prot:

WIBG_HUMAN
Domain:
  • The eIF2A-like region shares sequence similarity with eIF2A and mediates the interaction with the 40S ribosomal subunit and the 48S preinitiation complex.:
    • Q9BRP8
Family:
  • Belongs to the wibg family.:
    • Q9BRP8
genes like me logo Genes that share domains with WIBG: view

No data available for Gene Families for WIBG Gene

Function for WIBG Gene

Molecular function for WIBG Gene

UniProtKB/Swiss-Prot Function: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.

Gene Ontology (GO) - Molecular Function for WIBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18026120
GO:0043022 ribosome binding IDA 18026120
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with WIBG: view

Phenotypes for WIBG Gene

GenomeRNAi human phenotypes for WIBG:
genes like me logo Genes that share phenotypes with WIBG: view

miRNA for WIBG Gene

miRTarBase miRNAs that target WIBG

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WIBG Gene

Localization for WIBG Gene

Subcellular locations from UniProtKB/Swiss-Prot for WIBG Gene

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WIBG Gene COMPARTMENTS Subcellular localization image for WIBG gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WIBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
GO:0035145 exon-exon junction complex IDA 18026120
genes like me logo Genes that share ontologies with WIBG: view

Pathways for WIBG Gene

genes like me logo Genes that share pathways with WIBG: view

Pathways by source for WIBG Gene

2 KEGG pathways for WIBG Gene

Gene Ontology (GO) - Biological Process for WIBG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA 19410547
GO:0045727 positive regulation of translation IDA 18026120
GO:1903259 exon-exon junction complex disassembly IDA 19410547
genes like me logo Genes that share ontologies with WIBG: view

Compounds for WIBG Gene

(5) Novoseek inferred chemical compound relationships for WIBG Gene

Compound -log(P) Hits PubMed IDs
pingyangmycin 97.7 69
teniposide 62.9 4
psoralen 52.9 5
cisplatin 22.7 6
5fluorouracil 17.7 3
genes like me logo Genes that share compounds with WIBG: view

Transcripts for WIBG Gene

Unigene Clusters for WIBG Gene

Within bgcn homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WIBG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - - - - - -
SP3: -
SP4: - - - - -
SP5: - -

Relevant External Links for WIBG Gene

GeneLoc Exon Structure for
WIBG
ECgene alternative splicing isoforms for
WIBG

Expression for WIBG Gene

mRNA expression in normal human tissues for WIBG Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WIBG Gene

SOURCE GeneReport for Unigene cluster for WIBG Gene Hs.505687

genes like me logo Genes that share expressions with WIBG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WIBG Gene

Orthologs for WIBG Gene

This gene was present in the common ancestor of animals.

Orthologs for WIBG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WIBG 35
  • 99.67 (n)
  • 100 (a)
WIBG 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WIBG 35
  • 91.27 (n)
  • 95.81 (a)
WIBG 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WIBG 35
  • 92.15 (n)
  • 97.38 (a)
WIBG 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wibg 35
  • 86.67 (n)
  • 92.11 (a)
Wibg 16
Wibg 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WIBG 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wibg 35
  • 83.68 (n)
  • 85.26 (a)
chicken
(Gallus gallus)
Aves WIBG 35
  • 67.72 (n)
  • 72.11 (a)
WIBG 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WIBG 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13484 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.846 35
wibg 35
  • 65.74 (n)
  • 70.95 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6860 35
zebrafish
(Danio rerio)
Actinopterygii wibg 35
  • 66.87 (n)
  • 68.67 (a)
wibg 36
  • 55 (a)
OneToOne
zgc65891 35
fruit fly
(Drosophila melanogaster)
Insecta wibg 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T20G5.9 36
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for WIBG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WIBG Gene

ENSEMBL:
Gene Tree for WIBG (if available)
TreeFam:
Gene Tree for WIBG (if available)

Paralogs for WIBG Gene

No data available for Paralogs for WIBG Gene

Variants for WIBG Gene

Sequence variations from dbSNP and Humsavar for WIBG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs705710 -- 55,924,374(-) tgagc(A/C)tgcac intron-variant
rs705711 -- 55,924,427(-) ggcct(C/T)aagtg intron-variant
rs705712 -- 55,924,786(-) gacag(C/G)agaat intron-variant
rs705713 -- 55,924,826(-) ggtgg(C/T)gtggg intron-variant
rs705714 -- 55,926,542(-) GGACC(C/T)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WIBG Gene

Variant ID Type Subtype PubMed ID
nsv832424 CNV Loss 17160897
esv1266306 CNV Insertion 17803354

Relevant External Links for WIBG Gene

HapMap Linkage Disequilibrium report
WIBG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WIBG Gene

Disorders for WIBG Gene

(3) University of Copenhagen DISEASES for WIBG Gene

(6) Novoseek inferred disease relationships for WIBG Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 46.1 6
cancer lung 15.8 2
tumors 12.9 8
cancer 2.22 4
necrosis 0 2
genes like me logo Genes that share disorders with WIBG: view

No data available for UniProtKB/Swiss-Prot for WIBG Gene

Publications for WIBG Gene

  1. Disassembly of exon junction complexes by PYM. (PMID: 19410547) Gehring N.H. … Hentze M.W. (Cell 2009) 3 4 23
  2. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. (PMID: 18026120) Diem M.D. … Dreyfuss G. (Nat. Struct. Mol. Biol. 2007) 3 4 23
  3. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. (PMID: 12438415) Gatfield D. … Izaurralde E. (J. Cell Biol. 2002) 2 3 4
  4. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. (PMID: 14968132) Bono F. … Conti E. (EMBO Rep. 2004) 4 23
  5. An efficient protein complex purification method for functional proteomics in higher eukaryotes. (PMID: 12483225) Forler D. … Wilm M. (Nat. Biotechnol. 2003) 2 3

Products for WIBG Gene

Sources for WIBG Gene

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