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WIBG Gene

protein-coding   GIFtS: 54
GCID: GC12M056295

Within Bgcn Homolog (Drosophila)

  See WIBG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Within Bgcn Homolog (Drosophila)1 2
Protein Wibg Homolog2 3
PYM2 3
Partner Of Y14 And Mago2

External Ids:    HGNC: 302581   Entrez Gene: 843052   Ensembl: ENSG000001704737   UniProtKB: Q9BRP83   

Export aliases for WIBG gene to outside databases

Previous GC identifers: GC12M054582 GC12M053334


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WIBG Gene:
WIBG (within bgcn homolog (Drosophila)) is a protein-coding gene. Diseases associated with WIBG include mucoepidermoid carcinoma, and cavernous hemangioma. GO annotations related to this gene include ribosome binding and RNA binding.

UniProtKB/Swiss-Prot: WIBG_HUMAN, Q9BRP8
Function: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately
upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of
genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA
decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and
recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably
prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to
mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by
antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was
detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the WIBG gene promoter:
         AREB6   Egr-2   p53   c-Myb   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWIBG promoter sequence
   Search Chromatin IP Primers for WIBG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WIBG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

WIBG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WIBG gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056295:  view genomic region     (about GC identifiers)

Start:
56,295,197 bp from pter      End:
56,326,402 bp from pter
Size:
31,206 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WIBG_HUMAN, Q9BRP8 (See protein sequence)
Recommended Name: Partner of Y14 and mago  
Size: 204 amino acids; 22656 Da
Subunit: Interacts (via N-terminus) with MAGOH and RBM8A; the interaction is direct. Associates (eIF2A-like
region) with the 40S ribosomal subunit and the 48S preinitiation complex
Secondary accessions: B6ZDM5 Q8IXJ8 Q8N8E7
Alternative splicing: 2 isoforms:  Q9BRP8-1   Q9BRP8-2   

Explore the universe of human proteins at neXtProt for WIBG: NX_Q9BRP8

Explore proteomics data for WIBG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WIBG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137325.1  NP_115721.1  

    ENSEMBL proteins: 
     ENSP00000386156   ENSP00000381271   ENSP00000452447   ENSP00000448858   ENSP00000452291  
     ENSP00000402829  

    WIBG Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for WIBG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR015362 EJC_Pym

    Graphical View of Domain Structure for InterPro Entry Q9BRP8

    ProtoNet protein and cluster: Q9BRP8

    UniProtKB/Swiss-Prot: WIBG_HUMAN, Q9BRP8
    Domain: The eIF2A-like region shares sequence similarity with eIF2A and mediates the interaction with the 40S
    ribosomal subunit and the 48S preinitiation complex
    Similarity: Belongs to the wibg family


    Find genes that share domains with WIBG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WIBG_HUMAN, Q9BRP8
    Function: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately
    upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of
    genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA
    decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and
    recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably
    prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to
    mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by
    antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was
    detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI18026120
    GO:0043022ribosome binding IDA18026120
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with WIBG           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WIBG:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WIBG
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    miRTarBase miRNAs that target WIBG:
    hsa-mir-21-5p (MIRT000163)

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    Selected qRT-PCR Assays for microRNAs that regulate WIBG (see all 19):
    hsa-miR-4291 hsa-miR-15a hsa-miR-1260b hsa-miR-200a hsa-miR-141 hsa-miR-424 hsa-miR-375 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidWIBG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WIBG

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WIBG_HUMAN, Q9BRP8: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and
    the cytoplasm. Nuclear export is mediated by XPO1/CRM1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--
    GO:0035145exon-exon junction complex IDA18026120

    Find genes that share ontologies with WIBG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WIBG About    
    See pathways by source

    SuperPathContained pathways About
    1RNA transport
    RNA transport
    2mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with WIBG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for WIBG):
        RNA transport
    mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WIBG
    Interactions:

        Search GeneGlobe Interaction Network for WIBG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WIBG (Q9BRP81, 2, 3 ENSP000003861564) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGOHP613263, ENSP000003605254I2D: score=1 STRING: ENSP00000360525
    RBM8AQ9Y5S93, ENSP000003330014I2D: score=1 STRING: ENSP00000333001
    RPL23P628293, ENSP000003778654I2D: score=1 STRING: ENSP00000377865
    RPS6P627533, ENSP000003697574I2D: score=1 STRING: ENSP00000369757
    PRNPP041563I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA19410547
    GO:0045727positive regulation of translation IDA18026120

    Find genes that share ontologies with WIBG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WIBG

    5 Novoseek inferred chemical compound relationships for WIBG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pingyangmycin 97.7 161 11596291 (11), 17241428 (8), 9692057 (7), 18359702 (5) (see all 17)
    teniposide 62.9 8 15196390 (3), 12641948 (1)
    psoralen 52.9 9 7540529 (4), 1304460 (1)
    cisplatin 22.7 11 15196390 (3), 12641948 (2), 15014812 (1)
    5fluorouracil 17.7 4 12641948 (2), 9642344 (1)



    Find genes that share compounds with WIBG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WIBG gene (2 alternative transcripts): 
    NM_001143853.1  NM_032345.2  

    Unigene Cluster for WIBG:

    Within bgcn homolog (Drosophila)
    Hs.505687  [show with all ESTs]
    Unigene Representative Sequence: NM_032345
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000408946(uc001sif.1) ENST00000398213(uc001sie.1) ENST00000302533
    ENST00000557259 ENST00000547925 ENST00000549939 ENST00000454792(uc001sig.3)

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    Selected qRT-PCR Assays for microRNAs that regulate WIBG (see all 19):
    hsa-miR-4291 hsa-miR-15a hsa-miR-1260b hsa-miR-200a hsa-miR-141 hsa-miR-424 hsa-miR-375 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidWIBG 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat WIBG
      QuantiFast Probe-based Assays in human, mouse, rat WIBG

    Additional mRNA sequence: 

    AJ459406.1 AK096922.1 BC006135.1 BC014976.1 

    9 DOTS entries:

    DT.113147  DT.91744921  DT.101977014  DT.100814993  DT.91848585  DT.100814995  DT.121208095  DT.121208031 
    DT.454708 

    Selected AceView cDNA sequences (see all 130):

    BC009627 CR613330 CR606391 BQ641947 AA832520 BQ051512 AA775589 CF529060 
    BU172642 BU680972 CB160927 BI118172 AI004908 BI836558 CA448258 BX417184 
    BG828339 CB143972 BI224026 BU630124 AI377416 AL530008 BC008292 CB159392 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for WIBG    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                                            -                                 
    SP2:              -     -     -     -     -     -                                 
    SP3:              -                                                               
    SP4:                    -     -     -     -     -                                 
    SP5:                                      -     -                                 


    ECgene alternative splicing isoforms for WIBG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WIBG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCTGCCG
    WIBG Expression
    About this image

    WIBG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WIBG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505687
        Custom PCR Arrays for WIBG
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WIBG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WIBG gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wibg1 , 5 within bgcn homolog (Drosophila)1, 5 86.67(n)1
    92.11(a)1
      10 (77.14 cM)5
    784281  NM_001170869.21  NP_001164340.11 
     1287478795 
    chicken
    (Gallus gallus)
    Aves WIBG1 within bgcn homolog (Drosophila) 67.72(n)
    72.11(a)
      100858240  XM_003643452.2  XP_003643500.1 
    lizard
    (Anolis carolinensis)
    Reptilia WIBG6
    within bgcn homolog (Drosophila)
    63(a)
    1 ↔ 1
    GL343198.1(3211707-3218184)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.134842 Xenopus laevis transcribed sequence with weak similarity more 75.55(n)    CB199017.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658912 hypothetical protein MGC65891 78.48(n)   393566  BC056755.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wibg6
    within bgcn
    33(a)
    1 ↔ 1
    2R(19743478-19744457)
    worm
    (Caenorhabditis elegans)
    Secernentea T20G5.96
    Protein T20G5.9 (T20G5.9) mRNA, complete cds
    31(a)
    1 ↔ 1
    III(10209838-10211097) WBGene00011871


    ENSEMBL Gene Tree for WIBG (if available)
    TreeFam Gene Tree for WIBG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WIBG (see all 510)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151100071,2
    F--53333680(+) GAAACC/TGCGCC 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1886335341,2
    --53333690(+) CACTAA/CACTCC 2 -- int10--------
    rs111716951,2
    C,F--53333719(+) AGACTC/TCATCT 2 -- int14Minor allele frequency- T:0.21NA 126
    rs7724691,2
    C,H--53333767(-) gttacC/Tgtgcc 2 -- int113Minor allele frequency- T:0.05NA WA CSA EA 376
    rs1112409641,2
    F--53333858(+) ACATGG/ATGAAA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1489936801,2
    --53333898(+) GTGGTA/GGTGGG 2 -- int10--------
    rs1914909801,2
    C--53333925(+) TACTCA/GGGAGG 2 -- int10--------
    rs1836587421,2
    --53334062(+) CAATAC/TTTGTC 2 -- int10--------
    rs1437048021,2
    --53334097(+) CAATAC/TCTACT 2 -- int10--------
    rs31773371,2
    C--53334309(-) TAAAAG/AAAAAT 2 -- ut311Minor allele frequency- A:0.00MN 184

    HapMap Linkage Disequilibrium report for WIBG (56295197 - 56326402 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WIBG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1266306CNV Insertion17803354
    nsv832424CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WIBG
    DNA2.0 Custom Variant and Variant Library Synthesis for WIBG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for WIBG:    
    About MalaCards
    mucoepidermoid carcinoma    cavernous hemangioma

    3 diseases from the University of Copenhagen DISEASES database for WIBG:
    Tongue cancer     Cavernous hemangioma     Squamous cell carcinoma

    Find genes that share disorders with WIBG           About GenesLikeMe

    6 Novoseek inferred disease relationships for WIBG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 46.1 6 1706647 (2), 15196390 (1), 15014812 (1), 10745179 (1) (see all 5)
    cancer lung 15.8 2 1706647 (1), 12485505 (1)
    tumors 12.9 15 11596291 (3), 16288335 (2), 7540529 (1), 17241428 (1) (see all 5)
    cancer 2.22 4 8571778 (2), 18359702 (1), 1706647 (1)
    necrosis 0 2 10745179 (1), 17241428 (1)
    carcinoma 0 1 17241428 (1)


    Export disorders for WIBG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WIBG gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with WIBG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. (PubMed id 12438415)1, 2, 3 Gatfield D. and Izaurralde E. (J. Cell Biol. 2002)
    2. Disassembly of exon junction complexes by PYM. (PubMed id 19410547)1, 2, 9 Gehring N.H.... Hentze M.W. (Cell 2009)
    3. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. (PubMed id 18026120)1, 2, 9 Diem M.D.... Dreyfuss G. (Nat. Struct. Mol. Biol. 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. An efficient protein complex purification method for functional proteomics in higher eukaryotes. (PubMed id 12483225)1, 3 Forler D....Wilm M. (Nat. Biotechnol. 2003)
    6. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. (PubMed id 14968132)2, 9 Bono F....Conti E. (EMBO Rep. 2004)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (Cell 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84305 HGNC: 30258 AceView: PYM Ensembl:ENSG00000170473 euGenes: HUgn84305
    ECgene: WIBG Kegg: 84305 H-InvDB: WIBG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WIBG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WIBG gene:
    Search GeneIP for patents involving WIBG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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