Aliases for WHSC1L1 Gene
External Ids for WHSC1L1 Gene
Previous GeneCards Identifiers for WHSC1L1 Gene
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]
GeneCards Summary for WHSC1L1 Gene
WHSC1L1 (Wolf-Hirschhorn Syndrome Candidate 1-Like 1) is a Protein Coding gene. Diseases associated with WHSC1L1 include Leukemia, Acute Myeloid and Wolf-Hirschhorn Syndrome. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include histone-lysine N-methyltransferase activity and histone methyltransferase activity (H3-K27 specific). An important paralog of this gene is EHMT1.
UniProtKB/Swiss-Prot for WHSC1L1 Gene
Histone methyltransferase. Preferentially methylates Lys-4 and Lys-27 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation, while Lys-27 is a mark for transcriptional repression.