Aliases for WHSC1L1 Gene
External Ids for WHSC1L1 Gene
Previous GeneCards Identifiers for WHSC1L1 Gene
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]
GeneCards Summary for WHSC1L1 Gene
WHSC1L1 (Wolf-Hirschhorn Syndrome Candidate 1-Like 1) is a Protein Coding gene. Diseases associated with WHSC1L1 include wolf-hirschhorn syndrome and leukemia, acute myeloid. Among its related pathways are Chromatin organization and Lysine degradation. GO annotations related to this gene include histone-lysine N-methyltransferase activity and histone methyltransferase activity (H3-K27 specific). An important paralog of this gene is EHMT1.
UniProtKB/Swiss-Prot for WHSC1L1 Gene
Histone methyltransferase. Preferentially methylates Lys-4 and Lys-27 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation, while Lys-27 is a mark for transcriptional repression.