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WHAMM Gene

protein-coding   GIFtS: 46
GCID: GC15P083477

WAS Protein Homolog Associated With Actin, Golgi Membranes...

(Previous name: WAS protein homology region 2 domain containing 1)
(Previous symbol: WHDC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WAS Protein Homolog Associated With Actin, Golgi Membranes And
Microtubules1 2
     KIAA19713 5
WHDC11 2 3 5     WAS Protein Homology Region 2 Domain Containing 11
WAS Protein Homology Region 2 Domain-Containing Protein 12 3     WASP Homolog-Associated Protein With Actin, Membranes And Microtubules2
WH2 Domain-Containing Protein 12 3     

External Ids:    HGNC: 304931   Entrez Gene: 1237202   Ensembl: ENSG000001562327   OMIM: 6123935   UniProtKB: Q8TF303   

Export aliases for WHAMM gene to outside databases

Previous GC identifers: GC15P081277 GC15P059747


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WHAMM Gene:
This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule
binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3
complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments.
The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex
and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the
same arm of chromosome 15 as this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for WHAMM Gene:
WHAMM (WAS protein homolog associated with actin, golgi membranes and microtubules) is a protein-coding gene. Diseases associated with WHAMM include prader-willi syndrome, and wiskott-aldrich syndrome. GO annotations related to this gene include actin binding. An important paralog of this gene is JMY.

UniProtKB/Swiss-Prot: WHAMM_HUMAN, Q8TF30
Function: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at
the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology.
Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WHAMM gene promoter:
         RFX1   FOXF2   GCNF   MIF-1   YY1   GCNF-1   SEF-1 (1)   Meis-1a   GCNF-2   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for WHAMM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WHAMM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.2   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q25.2

WHAMM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WHAMM gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P083477:  view genomic region     (about GC identifiers)

Start:
83,477,973 bp from pter      End:
83,503,613 bp from pter
Size:
25,641 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WHAMM_HUMAN, Q8TF30 (See protein sequence)
Recommended Name: WASP homolog-associated protein with actin, membranes and microtubules  
Size: 809 amino acids; 90924 Da
Subunit: Interacts with actin, ACTR3 and microtubules
Sequence caution: Sequence=BAB85557.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB85557.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC05201.1;
Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
Secondary accessions: Q8N1J9

Explore the universe of human proteins at neXtProt for WHAMM: NX_Q8TF30

Explore proteomics data for WHAMM at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WHAMM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073904.1  
    ENSEMBL proteins: 
     ENSP00000286760  

    WHAMM Human Recombinant Protein Products:

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    Abcam antibodies for WHAMM
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    LSBio Antibodies in human, mouse, rat for WHAMM

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    Browse Enzo Life Sciences for kits & assays
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    Cloud-Clone Corp. CLIAs for WHAMM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026688 WHAMM
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry Q8TF30

    ProtoNet protein and cluster: Q8TF30

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: WHAMM_HUMAN, Q8TF30
    Domain: The N-terminal region associates with membranes, the coiled-coil region binds to microtubules and the WH2
    domains promotes actin nucleation
    Similarity: Contains 2 WH2 domains


    WHAMM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WHAMM_HUMAN, Q8TF30
    Function: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at
    the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology.
    Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003779actin binding IEA--
         
    WHAMM for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WHAMM
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    miRNA
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    miRTarBase miRNAs that target WHAMM:
    hsa-mir-99a-5p (MIRT048656)

    Block miRNA regulation of human, mouse, rat WHAMM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WHAMM (see all 12):
    hsa-miR-3650 hsa-miR-181c hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d hsa-miR-23b hsa-miR-3920
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WHAMM_HUMAN, Q8TF30: Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle
    membrane. Golgi apparatus, cis-Golgi network. Note=Localized to a perinuclear compartment near the
    microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that
    frequently localized along microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    golgi apparatus3
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--

    WHAMM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WHAMM
    Interactions:

        Search GeneGlobe Interaction Network for WHAMM

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WHAMM



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WHAMM gene: 
    NM_001080435.2  

    Unigene Cluster for WHAMM:

    WAS protein homolog associated with actin, golgi membranes and microtubules
    Hs.377360  [show with all ESTs]
    Unigene Representative Sequence: NM_001080435
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286760(uc002bje.3) ENST00000560964
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WHAMM (see all 12):
    hsa-miR-3650 hsa-miR-181c hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d hsa-miR-23b hsa-miR-3920
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QuantiTect SYBR Green Assays in human, mouse, rat WHAMM
      QuantiFast Probe-based Assays in human, mouse, rat WHAMM

    Additional mRNA sequence: 

    AB075851.1 AK097947.1 AK126887.1 

    8 DOTS entries:

    DT.211258  DT.100779241  DT.75101668  DT.95370595  DT.100736985  DT.40117367  DT.40118687  DT.92029110 

    Selected AceView cDNA sequences (see all 48):

    CK903680 CD721825 BI963715 AA709351 BF110189 BI966801 BF432996 AB075851 
    BM556230 BM846410 CK903681 BG109080 BU687025 BV205656 BX499885 AI023634 
    BQ082203 BI963976 BV205657 AA594411 AI865569 R48564 BV205655 AI720998 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WHAMM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGATCTAG
    WHAMM Expression
    About this image


    WHAMM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    WHAMM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WHAMM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.377360

    UniProtKB/Swiss-Prot: WHAMM_HUMAN, Q8TF30
    Tissue specificity: Expressed in brain, lung, heart, colon and kidney (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WHAMM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for WHAMM gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Whamm1 , 5 WAS protein homolog associated with actin, golgi membranes more1, 5 75.66(n)1
    68.83(a)1
      7 (45.71 cM)5
    4342041  NM_001004185.31  NP_001004185.31 
     815712925 
    chicken
    (Gallus gallus)
    Aves WHDC11 WAS protein homology region 2 domain containing 1 65.52(n)
    58.07(a)
      415457  XM_413835.4  XP_413835.2 
    lizard
    (Anolis carolinensis)
    Reptilia WHAMM6
    WAS protein homolog associated with actin, golgi m...
    52(a)
    1 ↔ 1
    GL343657.1(218002-230741)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia whamm1 WAS protein homolog associated with actin, golgi membranes more 61.57(n)
    53.91(a)
      100496908  XM_002939621.2  XP_002939667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7942021 WASP homolog-associated protein with actin, membranes more 54.27(n)
    46.73(a)
      794202  XM_001334079.5  XP_001334115.5 


    ENSEMBL Gene Tree for WHAMM (if available)
    TreeFam Gene Tree for WHAMM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WHAMM gene
    JMY2  
    2 SIMAP similar genes for WHAMM using alignment to 1 protein entry:     WHAMM_HUMAN:
    WHAMMP3    JMY

    WHAMM for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for WHAMM
    PGOHUM00000246664 PGOHUM00000258851 PGOHUM00000247031 PGOHUM00000258939


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WHAMM (see all 590)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913741481,2
    --83476825(+) CTCCTA/GACTTC 1 -- us2k10--------
    rs1465427341,2
    --83476840(+) GATCCA/GCCCAC 1 -- us2k10--------
    rs1827087701,2
    --83477029(+) AGAAAG/TATATT 1 -- us2k10--------
    rs1177711331,2
    F--83477075(+) TTAGTT/GAAAAT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1148613511,2
    F--83477080(+) TAAAAT/CAGTAT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs775171391,2
    C,F--83477145(+) ACTGAG/ATGACT 1 -- us2k12Minor allele frequency- A:0.08CSA WA 120
    rs1401963571,2
    --83477267(+) AGATTC/TCTTGA 1 -- us2k10--------
    rs1870334571,2
    --83477298(+) GATGCC/TCTAAC 1 -- us2k10--------
    rs777515051,2
    F--83477441(+) AACACC/GTCACA 1 -- us2k10--------
    rs727539741,2
    C,F--83477614(+) GTCTTG/CGTGCT 1 -- us2k11Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for WHAMM (83477973 - 83503613 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WHAMM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv9288CNV Loss18304495
    nsv471687CNV Gain15918152
    nsv469557CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612393    OMIM disorders: --

    2 diseases for WHAMM:    
    About MalaCards
    prader-willi syndrome    wiskott-aldrich syndrome


    WHAMM for disorders           About GeneDecksing


    Export disorders for WHAMM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WHAMM gene integrated from 10 sources:
    (articles sorted by number of sources associating them with WHAMM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport. (PubMed id 18614018)1, 2, 3 Campellone K.G.... Welch M.D. (Cell 2008)
    2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    3. Cytoskeletal regulation: coordinating actin and microtubule dynamics in membrane trafficking. (PubMed id 18812086)1, 3 Disanza A. and Scita G. (Curr. Biol. 2008)
    4. Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region. (PubMed id 18226259)1, 3 Jiang Y.-H.... Beaudet A.L. (BMC Genomics 2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. (PubMed id 23087206)1 Gad A.K....AspenstrAPm P. (Mol. Biol. Cell 2012)
    7. Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling. (PubMed id 23027905)1 Shen Q.T....Wang H.W. (J. Cell Biol. 2012)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 123720 HGNC: 30493 AceView: KIAA1971 Ensembl:ENSG00000156232 euGenes: HUgn123720
    ECgene: WHAMM H-InvDB: WHAMM

    (According to HUGE)
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    HUGE: KIAA1971

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WHAMM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WHAMM gene:
    Search GeneIP for patents involving WHAMM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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