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Aliases for WHAMM Gene

Aliases for WHAMM Gene

  • WAS Protein Homolog Associated With Actin, Golgi Membranes And Microtubules 2 3
  • WHDC1 3 4 6
  • WAS Protein Homology Region 2 Domain-Containing Protein 1 3 4
  • WH2 Domain-Containing Protein 1 3 4
  • KIAA1971 4 6
  • WASP Homolog-Associated Protein With Actin, Membranes And Microtubules 3
  • WAS Protein Homology Region 2 Domain Containing 1 2

External Ids for WHAMM Gene

Previous HGNC Symbols for WHAMM Gene

  • WHDC1

Previous GeneCards Identifiers for WHAMM Gene

  • GC15P081277
  • GC15P083477
  • GC15P059747

Summaries for WHAMM Gene

Entrez Gene Summary for WHAMM Gene

  • This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments. The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the same arm of chromosome 15 as this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for WHAMM Gene

WHAMM (WAS Protein Homolog Associated With Actin, Golgi Membranes And Microtubules) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is JMY.

UniProtKB/Swiss-Prot for WHAMM Gene

  • Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WHAMM Gene

Genomics for WHAMM Gene

Regulatory Elements for WHAMM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WHAMM Gene

Start:
82,808,218 bp from pter
End:
82,836,108 bp from pter
Size:
27,891 bases
Orientation:
Plus strand

Genomic View for WHAMM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WHAMM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WHAMM Gene

Proteins for WHAMM Gene

  • Protein details for WHAMM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF30-WHAMM_HUMAN
    Recommended name:
    WASP homolog-associated protein with actin, membranes and microtubules
    Protein Accession:
    Q8TF30
    Secondary Accessions:
    • Q8N1J9

    Protein attributes for WHAMM Gene

    Size:
    809 amino acids
    Molecular mass:
    90924 Da
    Quaternary structure:
    • Interacts with ACTR3; indicative for an association with the ARP2/3 complex. Associates with microtubules; in vitro binds to tubulin heterodimer in a 1:1 stoichiometry; decorates microtubules with a repeat of 80 A along protofilaments. Interacts with RHOD (in GTP-bound form).
    SequenceCaution:
    • Sequence=BAB85557.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB85557.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC05201.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

neXtProt entry for WHAMM Gene

Proteomics data for WHAMM Gene at MOPED

Post-translational modifications for WHAMM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WHAMM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WHAMM Gene

Domains for WHAMM Gene

Protein Domains for WHAMM Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for WHAMM Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF30

UniProtKB/Swiss-Prot:

WHAMM_HUMAN :
  • Q8TF30
Domain:
  • The N-terminal region associates with membranes, the coiled-coil region binds to microtubules and the WH2 domains promotes actin nucleation
  • Contains 2 WH2 domains.
genes like me logo Genes that share domains with WHAMM: view

No data available for Gene Families for WHAMM Gene

Function for WHAMM Gene

Molecular function for WHAMM Gene

UniProtKB/Swiss-Prot Function:
Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration.

Gene Ontology (GO) - Molecular Function for WHAMM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003779 actin binding IEA --
GO:0008017 microtubule binding IDA 18614018
GO:0017049 GTP-Rho binding IDA 23087206
GO:0071933 Arp2/3 complex binding IDA 23087206
genes like me logo Genes that share ontologies with WHAMM: view

Animal Model Products

miRNA for WHAMM Gene

miRTarBase miRNAs that target WHAMM

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WHAMM Gene

Localization for WHAMM Gene

Subcellular locations from UniProtKB/Swiss-Prot for WHAMM Gene

Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle membrane. Golgi apparatus, cis-Golgi network. Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules. {ECO:0000269 PubMed:18614018}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WHAMM Gene COMPARTMENTS Subcellular localization image for WHAMM gene
Compartment Confidence
cytosol 4
golgi apparatus 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for WHAMM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 18614018
GO:0005737 cytoplasm IDA --
GO:0005874 microtubule IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with WHAMM: view

Pathways for WHAMM Gene

SuperPathways for WHAMM Gene

No Data Available

Interacting Proteins for WHAMM Gene

Gene Ontology (GO) - Biological Process for WHAMM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IDA 18614018
GO:0007015 actin filament organization IDA 18614018
GO:0030032 lamellipodium assembly IMP 23087206
GO:0048041 focal adhesion assembly IMP 23087206
GO:0051127 positive regulation of actin nucleation IDA 18614018
genes like me logo Genes that share ontologies with WHAMM: view

No data available for Pathways by source for WHAMM Gene

Transcripts for WHAMM Gene

mRNA/cDNA for WHAMM Gene

Unigene Clusters for WHAMM Gene

WAS protein homolog associated with actin, golgi membranes and microtubules:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WHAMM

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WHAMM Gene

No ASD Table

Relevant External Links for WHAMM Gene

GeneLoc Exon Structure for
WHAMM
ECgene alternative splicing isoforms for
WHAMM

Expression for WHAMM Gene

mRNA expression in normal human tissues for WHAMM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for WHAMM Gene

This gene is overexpressed in Urine (63.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for WHAMM Gene

SOURCE GeneReport for Unigene cluster for WHAMM Gene Hs.377360

mRNA Expression by UniProt/SwissProt for WHAMM Gene

Q8TF30-WHAMM_HUMAN
Tissue specificity: Expressed in brain, lung, heart, colon and kidney (at protein level)
genes like me logo Genes that share expressions with WHAMM: view

Expression partners for WHAMM Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for WHAMM Gene

Orthologs for WHAMM Gene

This gene was present in the common ancestor of chordates.

Orthologs for WHAMM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WHAMM 35
  • 81.85 (n)
  • 75.22 (a)
WHAMM 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WHAMM 35
  • 78.66 (n)
  • 71.97 (a)
WHAMM 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Whamm 35
  • 75.66 (n)
  • 68.83 (a)
Whamm 16
Whamm 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WHAMM 35
  • 99.38 (n)
  • 99.63 (a)
WHAMM 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Whamm 35
  • 75.68 (n)
  • 68.4 (a)
oppossum
(Monodelphis domestica)
Mammalia WHAMM 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WHAMM 36
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves WHDC1 35
  • 65.52 (n)
  • 58.07 (a)
WHAMM 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WHAMM 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia whamm 35
  • 61.57 (n)
  • 53.91 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC794202 35
  • 54.27 (n)
  • 46.73 (a)
Species with no ortholog for WHAMM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WHAMM Gene

ENSEMBL:
Gene Tree for WHAMM (if available)
TreeFam:
Gene Tree for WHAMM (if available)

Paralogs for WHAMM Gene

Paralogs for WHAMM Gene

Selected SIMAP similar genes for WHAMM Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for WHAMM Gene

genes like me logo Genes that share paralogs with WHAMM: view

Variants for WHAMM Gene

Sequence variations from dbSNP and Humsavar for WHAMM Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1055666 - 82,818,003(+) AACTT(A/C)AGCTA missense, reference, nc-transcript-variant
rs1055667 - 82,818,019(+) AGCTC(A/G)AGAGA missense, reference, nc-transcript-variant
rs1133984 -- 82,818,053(+) GAGTT(A/G)TGTTT synonymous-codon, reference, nc-transcript-variant
rs1807242 -- 82,819,630(-) TGAAT(A/T)TATTA intron-variant
rs1971555 -- 82,822,886(-) tatat(A/C)catgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WHAMM Gene

Variant ID Type Subtype PubMed ID
nsv469557 CNV Complex 16826518
nsv471687 CNV Gain 15918152
nsv9288 CNV Loss 18304495

Relevant External Links for WHAMM Gene

HapMap Linkage Disequilibrium report
WHAMM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WHAMM Gene

Disorders for WHAMM Gene

No disorders were found for WHAMM Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for WHAMM Gene

Publications for WHAMM Gene

  1. WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport. (PMID: 18614018) Campellone K.G. … Welch M.D. (Cell 2008) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region. (PMID: 18226259) Jiang Y.-H. … Beaudet A.L. (BMC Genomics 2008) 2 3
  5. Cytoskeletal regulation: coordinating actin and microtubule dynamics in membrane trafficking. (PMID: 18812086) Disanza A. … Scita G. (Curr. Biol. 2008) 2 3

Products for WHAMM Gene

Sources for WHAMM Gene

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