WHAMM Gene
protein-coding GIFtS: 44
GCID: GC15P083477
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|
WAS protein homolog associated with actin, golgi membranes...(Previous name: WAS protein homology region 2 domain containing 1 )
(Previous symbol: WHDC1)
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Aliases
for WHAMM gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WAS Protein Homolog Associated With Actin, Golgi Membranes AndMicrotubules1 2 | | WAS Protein Homology Region 2 Domain-Containing Protein 12 3 | | WHDC11 2 3 5 | | WH2 Domain-Containing Protein 12 3 | | KIAA19711 3 5 | | WASP Homolog-Associated Protein With Actin, Membranes And Microtubules2 | | WAS Protein Homology Region 2 Domain Containing 11 2 | | |
Export aliases for WHAMM gene to outside databasesPrevious GC identifers: GC15P081277 GC15P059747 |
Summaries
for WHAMM gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: WHAMM_HUMAN, Q8TF30Function: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at theGolgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Participatesin vesicle transport between the reticulum endoplasmic and the Golgi complex
|
Genomic Views
for WHAMM gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_077661.3
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WHAMM gene promoter:
RFX1 FOXF2 GCNF MIF-1 YY1 GCNF-1 SEF-1 (1) Meis-1a GCNF-2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WHAMM
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WHAMM |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25.2 Ensembl cytogenetic band: 15q25.2 HGNC cytogenetic band: 15q25.2WHAMM Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P083477: view genomic region
(about GC identifiers)
Start:
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83,477,973 bp from pter |
End:
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83,503,613 bp from pter |
Size:
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25,641 bases |
Orientation:
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plus strand |
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Proteins
for WHAMM gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WHAMM_HUMAN, Q8TF30 (See
protein sequence)Recommended Name: WASP homolog-associated protein with actin, membranes and microtubules Size: 809 amino acids; 90924 Da
Subunit: Interacts with actin, ACTR3 and microtubules
Subcellular location: Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle membrane.Golgi apparatus, cis-Golgi network. Note=Localized to a perinuclear compartment near the microtubule-organizing center(MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized alongmicrotubules
Sequence caution: Sequence=BAB85557.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAB85557.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC05201.1;Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
Secondary accessions: Q8N1J9Explore the universe of human proteins at neXtProt for WHAMM: NX_Q8TF30
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TF30
WHAMM Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073904.1
ENSEMBL proteins: ENSP00000286760
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IDA | -- | | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
IEA | -- | | GO:0005794 | Golgi apparatus |
IEA | -- | | GO:0030659 | cytoplasmic vesicle membrane |
IEA | -- |
WHAMM for ontologies About GeneDecksing
WHAMM Antibody Products:
Assay Products for WHAMM: |
Protein
Domains /
Families
for WHAMM gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WHAMM for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TF30ProtoNet protein and cluster: Q8TF30 1 Blocks protein family: IPB003124 Actin-binding WH2
UniProtKB/Swiss-Prot: WHAMM_HUMAN, Q8TF30Domain: The N-terminal region associates with membranes, the coiled-coil region binds to microtubules and the WH2domains promotes actin nucleationSimilarity: Contains 2 WH2 domains |
Function
for WHAMM gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WHAMM_HUMAN, Q8TF30Function: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at theGolgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Participatesin vesicle transport between the reticulum endoplasmic and the Golgi complex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WHAMM (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WHAMM (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WHAMM |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003779 | actin binding |
IEA | -- |
WHAMM for ontologies About GeneDecksing
|
Pathways & Interactions
for WHAMM gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WHAMM
|
Drugs & Compounds
for WHAMM gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WHAMM
Search CenterWatch for drugs/clinical trials and news about WHAMM
|
Transcripts
for WHAMM gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WHAMM gene: NM_001080435.1 Unigene Cluster for WHAMM: WAS protein homolog associated with actin, golgi membranes and microtubules Hs.377360 [show with all ESTs]Unigene Representative Sequence: NM_0010804352 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000286760(uc002bje.3) ENST00000560964
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WHAMM (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WHAMM (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WHAMM (NM_001080435) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WHAMM | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WHAMM |
Additional cDNA sequence: AB075851.1 AK097947.1 AK126887.1 8 DOTS entries: DT.211258 DT.100779241 DT.75101668 DT.95370595 DT.100736985 DT.40117367 DT.40118687 DT.92029110 24/48 AceView cDNA sequences (see all 48): BM556230 BI966801 BF110189 BF432996 AB075851 BM846410 BI963715 CD721825 AA709351 CK903680 BU687025 BQ082202 BV205657 BV205656 CK903681 AI865569 AA594411 AI023634 BI963976 BG109080 BV205655 BQ082203 AK126887 BI962984
GeneLoc Exon Structure
|
Expression
for WHAMM gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WHAMM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGATCTAG
About this image
See WHAMM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WHAMM
SOURCE GeneReport for Unigene cluster: Hs.377360
UniProtKB/Swiss-Prot: WHAMM_HUMAN, Q8TF30Tissue specificity: Expressed in brain, lung, heart, colon and kidney (at protein level)
SABiosciences Custom PCR Arrays for WHAMM
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WHAMM
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WHAMM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WHAMM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WHAMM | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WHAMM |
Orthologs
for WHAMM gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for WHAMM gene from 3/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
WHDC11 |
WAS protein homology region 2 domain containing 1 |
65.52(n)
57.84(a) |
|
415457 XM_413835.3 XP_413835.2 |
lizard
(Anolis carolinensis) |
Reptilia |
WHAMM6 |
-- |
52(a) |
1 ↔ 1 |
GL343657.1(218002-230741) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7942021 |
WASP homolog-associated protein with actin, membranes more |
54.26(n)
47.3(a) |
|
794202 XM_001334079.4 XP_001334115.4 |
ENSEMBL Gene Tree for WHAMM (if available)
TreeFam Gene Tree for WHAMM (if available) |
Paralogs
for WHAMM gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WHAMM gene
- JMY2
2 SIMAP similar genes for WHAMM using alignment to 1 protein entry: WHAMM_HUMAN:WHAMMP3 JMY
WHAMM for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for WHAMM
PGOHUM00000246664 PGOHUM00000258851 PGOHUM00000247031 PGOHUM00000258939
|
Genomic Variants
for WHAMM gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WHAMM (83477973 - 83503613 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for WHAMM
2 CNVs: 32054 0789 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WHAMM |
|
Disorders
/ Diseases
for WHAMM gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WHAMM for disorders About GeneDecksing
OMIM gene information: 612393
OMIM disorders: --
2  diseases for WHAMM: About MalaCardsprader-willi syndrome wiskott-aldrich syndrome
Export disorders for WHAMM gene to outside databases
|
Publications
for WHAMM gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WHAMM gene integrated from 9 sources:
(articles sorted by number of sources associating them with WHAMM) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport. (PubMed id 18614018)1, 2, 3 Campellone K.G.... Welch M.D. (2008)
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
- Cytoskeletal regulation: coordinating actin and microtubule dynamics in membrane trafficking. (PubMed id 18812086)1, 3 Disanza A. and Scita G. (2008)
- Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region. (PubMed id 18226259)1, 3 Jiang Y.-H.... Beaudet A.L. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Structural insights into WHAMM-mediated cytoskeletal c oordination during membrane remodeling. (PubMed id 23027905)1 Shen Q.T....Wang H.W. (2012)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
|
External Searches for WHAMM gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WHAMM gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WHAMM gene
(According to HUGE)
About This Section
| |
Specialized Databases showing WHAMM gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WHAMM | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WHAMM gene:
Search GeneIP for patents involving WHAMM
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WHAMM gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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 | | | WHAMM Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WHAMM |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WHAMM |
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