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WFIKKN2 Gene

protein-coding   GIFtS: 50
GCID: GC17P048912

WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin...

  Search for WFIKKN2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain
Containing 21 2
     WFIKKN-Related Protein2 3
WFIKKNRP2 3 5     WFDC20B2
WAP Four-Disulfide Core Domain 20B1 2     Multivalent Protease Inhibitor Protein2
Growth And Differentiation Factor-Associated Serum Protein 12 3     WAP, FS, Ig, Two KU And NTR Module Related Protein2
WAP, Follistatin, Immunoglobulin, Kunitz And NTR Domain-Containing-Related
Protein2 3
     WAP, Kazal, Immunoglobulin, Kunitz And NTR Domain-Containing Protein 22
GASP-12 3     GASP13
hGASP-12 3     

External Ids:    HGNC: 309161   Entrez Gene: 1248572   Ensembl: ENSG000001737147   OMIM: 6108955   UniProtKB: Q8TEU83   

Export aliases for WFIKKN2 gene to outside databases

Previous GC identifers: GC17P046267 GC17P044279


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WFIKKN2 Gene:
The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains,
and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the
WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may
control the action of multiple types of proteases. (provided by RefSeq, Jul 2008)

GeneCards Summary for WFIKKN2 Gene:
WFIKKN2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2) is a protein-coding gene. GO annotations related to this gene include metalloendopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. An important paralog of this gene is AMBP.

UniProtKB/Swiss-Prot: WFKN2_HUMAN, Q8TEU8
Function: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine
protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not
activin (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the WFIKKN2 gene promoter:
         ISGF-3   RFX1   MAZR   CUTL1   LUN-1   C/EBPalpha   AREB6   N-Myc   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWFIKKN2 promoter sequence
   Search Chromatin IP Primers for WFIKKN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WFIKKN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

WFIKKN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WFIKKN2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P048912:  view genomic region     (about GC identifiers)

Start:
48,912,011 bp from pter      End:
48,919,709 bp from pter
Size:
7,699 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WFKN2_HUMAN, Q8TEU8 (See protein sequence)
Recommended Name: WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 precursor  
Size: 576 amino acids; 63941 Da
Subunit: Interacts with both mature and propeptide myostatin/MSTN
Secondary accessions: Q6UXZ9

Explore the universe of human proteins at neXtProt for WFIKKN2: NX_Q8TEU8

Explore proteomics data for WFIKKN2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn319, Asn519
  • Modification sites at PhosphoSitePlus

  • See WFIKKN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_783165.1  
    ENSEMBL proteins: 
     ENSP00000405889   ENSP00000311184  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing
    WFDC: WAP four-disulfide core domain containing

    Selected InterPro protein domains (see all 11):
     IPR003598 Ig_sub2
     IPR008993 TIMP-like_OB-fold
     IPR002350 Kazal_dom
     IPR013098 Ig_I-set
     IPR002223 Prot_inh_Kunz-m

    Graphical View of Domain Structure for InterPro Entry Q8TEU8

    ProtoNet protein and cluster: Q8TEU8

    4 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB008197 4-disulphide core signature
    IPB011497 Protease inhibitor
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: WFKN2_HUMAN, Q8TEU8
    Similarity: Belongs to the WFIKKN family
    Similarity: Contains 2 BPTI/Kunitz inhibitor domains
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 NTR domain
    Similarity: Contains 1 WAP domain


    Find genes that share domains with WFIKKN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WFKN2_HUMAN, Q8TEU8
    Function: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine
    protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not
    activin (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0005515protein binding ----
    GO:0008191metalloendopeptidase inhibitor activity IEA--
    GO:0030414peptidase inhibitor activity ----
         
    Find genes that share ontologies with WFIKKN2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Wfikkn2):
     craniofacial  digestive/alimentary  muscle  skeleton 

    Find genes that share phenotypes with WFIKKN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wfikkn2tm1.1Sjl for WFIKKN2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WFIKKN2
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    SwitchGear 3'UTR luciferase reporter plasmidWFIKKN2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WFKN2_HUMAN, Q8TEU8: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    mitochondrion2
    plasma membrane2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with WFIKKN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WFIKKN2
    Interactions:

        Search GeneGlobe Interaction Network for WFIKKN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for WFIKKN2 (Q8TEU82, 3 ENSP000003111844) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP4P126442, 3, ENSP000002454514MINT-8044135 I2D: score=1 STRING: ENSP00000245451
    BMP8BP348202, 3, ENSP000003619154MINT-8044393 I2D: score=1 STRING: ENSP00000361915
    TGFB1P011372, 3, ENSP000002219304MINT-8044312 I2D: score=1 STRING: ENSP00000221930
    BMP2P126432, 3, ENSP000003681044MINT-8044372 I2D: score=1 STRING: ENSP00000368104
    BMP3P126452, 3, ENSP000002827014MINT-8044382 I2D: score=1 STRING: ENSP00000282701
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007179transforming growth factor beta receptor signaling pathway IEA--

    Find genes that share ontologies with WFIKKN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for WFIKKN2 (WFKN2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WFIKKN2 gene: 
    NM_175575.5  

    Unigene Cluster for WFIKKN2:

    WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
    Hs.211475  [show with all ESTs]
    Unigene Representative Sequence: NM_175575
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426127 ENST00000311378(uc010dbu.3 uc002isv.4)
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    hsa-miR-186* hsa-miR-3660 hsa-miR-3160-3p hsa-miR-4261 hsa-miR-141* hsa-miR-138 hsa-miR-608 hsa-miR-3915
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    Additional mRNA sequence: 

    AF468657.1 AK127743.1 AK131196.1 AK298172.1 AK312821.1 AY358142.1 BC140842.1 BC140844.1 

    1 DOTS entry:

    DT.101979443 

    Selected AceView cDNA sequences (see all 26):

    AF468657 F27556 BQ954191 BX108923 NM_175575 BX433163 AL540240 BX464797 
    AW468704 BX452077 AA364422 AY358142 CA394579 AL537450 BX461258 AI919298 
    AI833106 AK127743 AI932781 AL540239 BX424452 CD671934 BG221308 AL537449 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WFIKKN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAATAGCA
    WFIKKN2 Expression
    About this image


    WFIKKN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    WFIKKN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WFIKKN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211475

    UniProtKB/Swiss-Prot: WFKN2_HUMAN, Q8TEU8
    Tissue specificity: Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is
    primarily expressed in brain, skeletal muscle, thymus and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WFIKKN2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wfikkn21 , 5 WAP, follistatin/kazal, immunoglobulin, kunitz and more1, 5 86.4(n)1
    92.29(a)1
      11 (58.90 cM)5
    2785071  NM_181819.21  NP_861540.21 
     942359565 
    chicken
    (Gallus gallus)
    Aves WFIKKN21 WAP, follistatin/kazal, immunoglobulin, kunitz and more 74.14(n)
    79.81(a)
      422097  XM_420100.3  XP_420100.2 
    lizard
    (Anolis carolinensis)
    Reptilia WFIKKN26
    WAP, follistatin/kazal, immunoglobulin, kunitz and...
    75(a)
    1 ↔ 1
    2(117409527-117417396)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.175612 Xenopus laevis transcribed sequence with weak similarity more 77.97(n)    BG812819.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5649921 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing more 68.47(n)
    67.6(a)
      564992  XM_688302.5  XP_693394.5 
    worm
    (Caenorhabditis elegans)
    Secernentea F22E12.16
    ZK287.46
    (see all 4)
    Protein F22E12.1 (F22E12.1) mRNA, complete cds
    Protein ZK287.4, isoform c (ZK287.4) mRNA, complet...
    (see all 4)
    8(a)
    7(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    V(10453866-10457347) WBGene00009058
    V(9680375-9685659) WBGene00013965


    ENSEMBL Gene Tree for WFIKKN2 (if available)
    TreeFam Gene Tree for WFIKKN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WFIKKN2 gene
    AMBP2  SPINT32  TFPI22  WFIKKN12  TFPI2  
    5 SIMAP similar genes for WFIKKN2 using alignment to 2 protein entries:     WFKN2_HUMAN (see all proteins):
    WFIKKN1    SPINT3    ITIL    TFPI2    EPPIN

    Find genes that share paralogs with WFIKKN2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WFIKKN2 (see all 279)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783315861,2
    C,Funtested148917215(+) ACCACC/TTGAGA 2 P L mis11Minor allele frequency- T:0.33NA 6
    rs1408216131,2
    --48910644(+) TGGGAA/GACTTG 1 -- us2k10--------
    rs1833811361,2
    --48910649(+) GACTTC/GGAAGG 1 -- us2k10--------
    rs1873436271,2
    --48910655(+) GAAGGG/TCTGGA 1 -- us2k10--------
    rs1917994331,2
    --48910696(+) TTTCCC/TGATGC 1 -- us2k10--------
    rs46115021,2
    C,F,A,H--48910781(+) CCAGGT/CTGGGT 1 -- us2k115Minor allele frequency- C:0.42NS EA NA WA CSA 791
    rs1825384761,2
    --48910785(+) GTTGGG/TTGTGG 1 -- us2k10--------
    rs1447780371,2
    C--48911158(+) ATTACA/GGGGAA 1 -- us2k10--------
    rs1868626601,2
    --48911229(+) AGTTTA/TTTCCA 1 -- us2k10--------
    rs1176265411,2
    C,F--48911270(+) TCATTA/GGCGAT 1 -- us2k11Minor allele frequency- G:0.05NA 120

    HapMap Linkage Disequilibrium report for WFIKKN2 (48912011 - 48919709 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WFIKKN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716041CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WFIKKN2
    DNA2.0 Custom Variant and Variant Library Synthesis for WFIKKN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610895    OMIM disorders: --


    Find genes that share disorders with WFIKKN2           About GenesLikeMe


    Export disorders for WFIKKN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WFIKKN2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with WFIKKN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules. (PubMed id 11928817)1, 2, 3, 9 Trexler M.... Patthy L. (Biol. Chem. 2002)
    2. Regulation of myostatin in vivo by growth and differentiation factor- associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. (PubMed id 12595574)1, 2 Hill J.J.... Wolfman N.M. (Mol. Endocrinol. 2003)
    3. Expression, purification and characterization of the second Kunitz- type protease inhibitor domain of the human WFIKKN protein. (PubMed id 12709070)1, 3 Nagy A.... Patthy L. (Eur. J. Biochem. 2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. (PubMed id 18596030)1, 9 KondA!s K....Patthy L. (J. Biol. Chem. 2008)
    6. Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2. (PubMed id 23829672)1 SzlA!ma G....Patthy L. (FEBS J. 2013)
    7. Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women. (PubMed id 22395277)1 Dieli-Conwright C.M....Schroeder E.T. (amp 2012)
    8. Effects of oral creatine and resistance training on serum myostatin and GASP-1. (PubMed id 20026378)1 Saremi A....Omidfar K. (Mol. Cell. Endocrinol. 2010)
    9. WFIKKN1 and WFIKKN2 bind growth factors TGFI^1, BMP2 and BMP4 but do not inhibit their signalling activity. (PubMed id 21054789)1 SzlA!ma G....Patthy L. (FEBS J. 2010)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124857 HGNC: 30916 AceView: WFIKKN2 Ensembl:ENSG00000173714 euGenes: HUgn124857
    ECgene: WFIKKN2 H-InvDB: WFIKKN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WFIKKN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WFIKKN2 gene:
    Search GeneIP for patents involving WFIKKN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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