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Aliases for WFIKKN2 Gene

Aliases for WFIKKN2 Gene

  • WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 2 2 3 5
  • WAP, Follistatin, Immunoglobulin, Kunitz And NTR Domain-Containing-Related Protein 3 4
  • Growth And Differentiation Factor-Associated Serum Protein 1 3 4
  • WAP Four-Disulfide Core Domain 20B 2 3
  • WFIKKN-Related Protein 3 4
  • WFIKKNRP 3 4
  • HGASP-1 3 4
  • GASP-1 3 4
  • WAP, Kazal, Immunoglobulin, Kunitz And NTR Domain-Containing Protein 2 3
  • WAP, FS, Ig, Two KU And NTR Module Related Protein 3
  • Multivalent Protease Inhibitor Protein 3
  • WFDC20B 3
  • GASP1 4

External Ids for WFIKKN2 Gene

Previous GeneCards Identifiers for WFIKKN2 Gene

  • GC17P046267
  • GC17P048912
  • GC17P044279

Summaries for WFIKKN2 Gene

Entrez Gene Summary for WFIKKN2 Gene

  • The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFIKKN2 Gene

WFIKKN2 (WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and metalloendopeptidase inhibitor activity. An important paralog of this gene is WFIKKN1.

UniProtKB/Swiss-Prot for WFIKKN2 Gene

  • Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity).

Additional gene information for WFIKKN2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFIKKN2 Gene

Genomics for WFIKKN2 Gene

Regulatory Elements for WFIKKN2 Gene


Enhancers around WFIKKN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for WFIKKN2 Gene

Chromosome:
17
Start:
50,834,650 bp from pter
End:
50,842,348 bp from pter
Size:
7,699 bases
Orientation:
Plus strand

Genomic View for WFIKKN2 Gene

Genes around WFIKKN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFIKKN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFIKKN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFIKKN2 Gene

Proteins for WFIKKN2 Gene

  • Protein details for WFIKKN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEU8-WFKN2_HUMAN
    Recommended name:
    WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
    Protein Accession:
    Q8TEU8
    Secondary Accessions:
    • Q6UXZ9

    Protein attributes for WFIKKN2 Gene

    Size:
    576 amino acids
    Molecular mass:
    63941 Da
    Quaternary structure:
    • Interacts with both mature and propeptide myostatin/MSTN.

neXtProt entry for WFIKKN2 Gene

Post-translational modifications for WFIKKN2 Gene

  • Glycosylation at Asn319 and posLast=519519
  • Modification sites at PhosphoSitePlus

Other Protein References for WFIKKN2 Gene

No data available for DME Specific Peptides for WFIKKN2 Gene

Domains & Families for WFIKKN2 Gene

Gene Families for WFIKKN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for WFIKKN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TEU8

UniProtKB/Swiss-Prot:

WFKN2_HUMAN :
  • Belongs to the WFIKKN family.
Family:
  • Belongs to the WFIKKN family.
genes like me logo Genes that share domains with WFIKKN2: view

Function for WFIKKN2 Gene

Molecular function for WFIKKN2 Gene

UniProtKB/Swiss-Prot Function:
Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity).

Phenotypes From GWAS Catalog for WFIKKN2 Gene

Gene Ontology (GO) - Molecular Function for WFIKKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 18596030
GO:0008191 metalloendopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFIKKN2: view
genes like me logo Genes that share phenotypes with WFIKKN2: view

Animal Models for WFIKKN2 Gene

MGI Knock Outs for WFIKKN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for WFIKKN2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WFIKKN2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WFIKKN2 Gene

Localization for WFIKKN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFIKKN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFIKKN2 gene
Compartment Confidence
extracellular 4
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for WFIKKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 12595574
genes like me logo Genes that share ontologies with WFIKKN2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WFIKKN2 Gene

Pathways & Interactions for WFIKKN2 Gene

SuperPathways for WFIKKN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WFIKKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway IEA,ISS 12595574
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA 21054789
genes like me logo Genes that share ontologies with WFIKKN2: view

No data available for Pathways by source and SIGNOR curated interactions for WFIKKN2 Gene

Drugs & Compounds for WFIKKN2 Gene

No Compound Related Data Available

Transcripts for WFIKKN2 Gene

mRNA/cDNA for WFIKKN2 Gene

Unigene Clusters for WFIKKN2 Gene

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WFIKKN2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WFIKKN2 Gene

No ASD Table

Relevant External Links for WFIKKN2 Gene

GeneLoc Exon Structure for
WFIKKN2
ECgene alternative splicing isoforms for
WFIKKN2

Expression for WFIKKN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WFIKKN2 Gene

mRNA differential expression in normal tissues according to GTEx for WFIKKN2 Gene

This gene is overexpressed in Ovary (x44.3).

Protein differential expression in normal tissues from HIPED for WFIKKN2 Gene

This gene is overexpressed in Cerebrospinal fluid (24.9), Fetal Brain (14.8), Ovary (10.8), and Liver (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WFIKKN2 Gene



Protein tissue co-expression partners for WFIKKN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of WFIKKN2 Gene:

WFIKKN2

SOURCE GeneReport for Unigene cluster for WFIKKN2 Gene:

Hs.211475

mRNA Expression by UniProt/SwissProt for WFIKKN2 Gene:

Q8TEU8-WFKN2_HUMAN
Tissue specificity: Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney.

Evidence on tissue expression from TISSUES for WFIKKN2 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with WFIKKN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for WFIKKN2 Gene

Orthologs for WFIKKN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WFIKKN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WFIKKN2 33 34
  • 97.17 (n)
dog
(Canis familiaris)
Mammalia WFIKKN2 33 34
  • 90.24 (n)
cow
(Bos Taurus)
Mammalia WFIKKN2 33 34
  • 88.79 (n)
oppossum
(Monodelphis domestica)
Mammalia WFIKKN2 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wfikkn2 33 16 34
  • 86.4 (n)
rat
(Rattus norvegicus)
Mammalia Wfikkn2 33
  • 86.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves WFIKKN2 33 34
  • 74.14 (n)
lizard
(Anolis carolinensis)
Reptilia WFIKKN2 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wfikkn2 33
  • 70.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17561 33
zebrafish
(Danio rerio)
Actinopterygii LOC564992 33
  • 68.47 (n)
wfikkn2a 34
  • 65 (a)
OneToMany
WFIKKN2 (2 of 2) 34
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mec-9 34
  • 10 (a)
ManyToMany
F22E12.1 34
  • 8 (a)
ManyToMany
ZK287.4 34
  • 7 (a)
ManyToMany
mec-1 34
  • 5 (a)
ManyToMany
Species where no ortholog for WFIKKN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WFIKKN2 Gene

ENSEMBL:
Gene Tree for WFIKKN2 (if available)
TreeFam:
Gene Tree for WFIKKN2 (if available)

Paralogs for WFIKKN2 Gene

Paralogs for WFIKKN2 Gene

(5) SIMAP similar genes for WFIKKN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WFIKKN2: view

Variants for WFIKKN2 Gene

Sequence variations from dbSNP and Humsavar for WFIKKN2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000136424 -- 50,839,165(+) GAGTC(C/T)TTGGC intron-variant
rs1001032025 -- 50,838,296(+) GGGTA(-/G)AACAG intron-variant
rs1001137102 -- 50,838,485(+) GCCAA(A/G)TGGGT intron-variant
rs1001237667 -- 50,839,207(+) CTTGG(A/C/G)AAAGT intron-variant
rs1001701765 -- 50,833,044(+) CATGG(G/T)CTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WFIKKN2 Gene

Variant ID Type Subtype PubMed ID
esv2716041 CNV deletion 23290073

Variation tolerance for WFIKKN2 Gene

Residual Variation Intolerance Score: 12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WFIKKN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WFIKKN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFIKKN2 Gene

Disorders for WFIKKN2 Gene

Relevant External Links for WFIKKN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WFIKKN2

No disorders were found for WFIKKN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFIKKN2 Gene

Publications for WFIKKN2 Gene

  1. Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules. (PMID: 11928817) Trexler M … Patthy L (Biological chemistry 2002) 2 3 4 22 60
  2. Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. (PMID: 18596030) Kondás K … Patthy L (The Journal of biological chemistry 2008) 3 22 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  4. Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein. (PMID: 12709070) Nagy A … Patthy L (European journal of biochemistry 2003) 2 3 60
  5. Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. (PMID: 12595574) Hill JJ … Wolfman NM (Molecular endocrinology (Baltimore, Md.) 2003) 3 4 60

Products for WFIKKN2 Gene

Sources for WFIKKN2 Gene

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