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Aliases for WFIKKN1 Gene

Aliases for WFIKKN1 Gene

  • WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 1 2 3
  • WFIKKN 3 4 6
  • WAP, Follistatin, Immunoglobulin, Kunitz And NTR Domain-Containing Protein 3 4
  • Growth And Differentiation Factor-Associated Serum Protein 2 3 4
  • WAP Four-Disulfide Core Domain 20A 2 3
  • C16orf12 3 4
  • HGASP-2 3 4
  • GASP-2 3 4
  • WAP, Kazal, Immunoglobulin, Kunitz And NTR Domain-Containing Protein 1 3
  • WAP, FS, Ig, KU, And NTR-Containing Protein 3
  • Chromosome 16 Open Reading Frame 12 2
  • WFDC20A 3
  • GASP2 4
  • RJD2 3

External Ids for WFIKKN1 Gene

Previous HGNC Symbols for WFIKKN1 Gene

  • C16orf12

Previous GeneCards Identifiers for WFIKKN1 Gene

  • GC16P000622
  • GC16P000623
  • GC16P000680
  • GC16P000602
  • GC16P000681
  • GC16P000682
  • GC16P000683
  • GC16P000689

Summaries for WFIKKN1 Gene

Entrez Gene Summary for WFIKKN1 Gene

  • This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFIKKN1 Gene

WFIKKN1 (WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and metalloendopeptidase inhibitor activity. An important paralog of this gene is TFPI.

UniProtKB/Swiss-Prot for WFIKKN1 Gene

  • Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity).

Gene Wiki entry for WFIKKN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFIKKN1 Gene

Genomics for WFIKKN1 Gene

Genomic Location for WFIKKN1 Gene

629,239 bp from pter
634,116 bp from pter
4,878 bases
Plus strand

Genomic View for WFIKKN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WFIKKN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFIKKN1 Gene

Proteins for WFIKKN1 Gene

  • Protein details for WFIKKN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q7LDW0
    • Q8NBQ1
    • Q96S20

    Protein attributes for WFIKKN1 Gene

    548 amino acids
    Molecular mass:
    58798 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK61237.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC11566.1; Type=Frameshift; Positions=147; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WFIKKN1 Gene

neXtProt entry for WFIKKN1 Gene

Proteomics data for WFIKKN1 Gene at MOPED

Post-translational modifications for WFIKKN1 Gene

  • Glycosylation at Asn493
  • Modification sites at PhosphoSitePlus

Other Protein References for WFIKKN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFIKKN1 Gene

Domains for WFIKKN1 Gene

Gene Families for WFIKKN1 Gene

  • ISET :Immunoglobulin superfamily / I-set domain containing
  • WFDC :WAP four-disulfide core domain containing

Suggested Antigen Peptide Sequences for WFIKKN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96NZ8
  • The second BPTI/Kunitz inhibitor domain is able to inhibit trypsin. It has however no activity toward chymotrypsin, elastase, plasmin, pancreatic kallikrein, lung tryptase, plasma kallikrein, thrombin, urokinase or tissue plasminogen activator.
  • Contains 2 BPTI/Kunitz inhibitor domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Kazal-like domain.
  • Contains 1 NTR domain.
  • Contains 1 WAP domain.
  • Belongs to the WFIKKN family.
genes like me logo Genes that share domains with WFIKKN1: view

Function for WFIKKN1 Gene

Molecular function for WFIKKN1 Gene

UniProtKB/Swiss-Prot Function: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity).

Gene Ontology (GO) - Molecular Function for WFIKKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 23829672
GO:0008191 metalloendopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity --
genes like me logo Genes that share ontologies with WFIKKN1: view
genes like me logo Genes that share phenotypes with WFIKKN1: view

Animal Models for WFIKKN1 Gene

MGI Knock Outs for WFIKKN1:

miRNA for WFIKKN1 Gene

miRTarBase miRNAs that target WFIKKN1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WFIKKN1 Gene

Localization for WFIKKN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFIKKN1 Gene


Subcellular locations from

Jensen Localization Image for WFIKKN1 Gene COMPARTMENTS Subcellular localization image for WFIKKN1 gene
Compartment Confidence
extracellular 3
cytosol 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WFIKKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFIKKN1: view

Pathways for WFIKKN1 Gene

SuperPathways for WFIKKN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WFIKKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0032091 negative regulation of protein binding IEA --
GO:0043392 negative regulation of DNA binding IEA --
GO:0048747 muscle fiber development IEA --
genes like me logo Genes that share ontologies with WFIKKN1: view

No data available for Pathways by source for WFIKKN1 Gene

Transcripts for WFIKKN1 Gene

mRNA/cDNA for WFIKKN1 Gene

Unigene Clusters for WFIKKN1 Gene

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WFIKKN1 Gene

No ASD Table

Relevant External Links for WFIKKN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFIKKN1 Gene

mRNA expression in normal human tissues for WFIKKN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WFIKKN1 Gene

This gene is overexpressed in Brain - Cerebellum (5.5) and Brain - Cerebellar Hemisphere (5.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for WFIKKN1 Gene

SOURCE GeneReport for Unigene cluster for WFIKKN1 Gene Hs.345818

mRNA Expression by UniProt/SwissProt for WFIKKN1 Gene

Tissue specificity: Expressed in pancreas, kidney, liver, placenta, and lung
genes like me logo Genes that share expressions with WFIKKN1: view

Orthologs for WFIKKN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for WFIKKN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WFIKKN1 35
  • 86.56 (n)
  • 88.18 (a)
  • 87 (a)
(Canis familiaris)
Mammalia WFIKKN1 35
  • 86.5 (n)
  • 88.51 (a)
  • 87 (a)
(Mus musculus)
Mammalia Wfikkn1 35
  • 82.52 (n)
  • 88.53 (a)
Wfikkn1 16
Wfikkn1 36
  • 87 (a)
(Monodelphis domestica)
Mammalia WFIKKN1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
(Rattus norvegicus)
Mammalia Wfikkn1 35
  • 82.46 (n)
  • 88.16 (a)
(Gallus gallus)
Aves WFIKKN1 35
  • 76.89 (n)
  • 69.9 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia WFIKKN1 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wfikkn1 35
  • 60.67 (n)
  • 59.88 (a)
(Danio rerio)
Actinopterygii wfikkn1 35
  • 64.44 (n)
  • 55.15 (a)
wfikkn1 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea F22E12.1 36
  • 8 (a)
mec-1 36
  • 5 (a)
mec-9 36
  • 10 (a)
ZK287.4 36
  • 7 (a)
Species with no ortholog for WFIKKN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WFIKKN1 Gene

Gene Tree for WFIKKN1 (if available)
Gene Tree for WFIKKN1 (if available)

Paralogs for WFIKKN1 Gene

Paralogs for WFIKKN1 Gene

Selected SIMAP similar genes for WFIKKN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFIKKN1: view

Variants for WFIKKN1 Gene

Sequence variations from dbSNP and Humsavar for WFIKKN1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2269558 -- 632,250(+) TGCTG(C/T)AGCCG intron-variant
rs2269559 -- 632,297(+) GGTGG(C/T)CCTGA intron-variant
rs2269560 -- 632,442(+) TGGAA(A/C)GGACA intron-variant
rs2269561 -- 632,566(+) CTAAG(C/T)GTCCC intron-variant
rs4984903 -- 630,695(+) CCCCC(A/G)TGGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WFIKKN1 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904707 CNV Loss 21882294
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2479n71 CNV Loss 21882294
nsv833114 CNV Gain+Loss 17160897
nsv471063 CNV Loss 18288195
dgv2484n71 CNV Loss 21882294
dgv2485n71 CNV Loss 21882294
nsv904759 CNV Loss 21882294
dgv334n27 CNV Loss 19166990
nsv904760 CNV Loss 21882294
dgv2487n71 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
nsv904779 CNV Loss 21882294
nsv904781 CNV Gain 21882294
nsv471065 CNV Gain 18288195
dgv2489n71 CNV Loss 21882294
nsv904785 CNV Gain+Loss 21882294
dgv2490n71 CNV Loss 21882294
esv2750214 CNV Deletion 23290073
dgv352e201 CNV Deletion 23290073
esv2750216 CNV Deletion 23290073

Relevant External Links for WFIKKN1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFIKKN1 Gene

Disorders for WFIKKN1 Gene

No disorders were found for WFIKKN1 Gene.

No data available for UniProtKB/Swiss-Prot for WFIKKN1 Gene

Publications for WFIKKN1 Gene

  1. A human protein containing multiple types of protease-inhibitory modules. (PMID: 11274388) Trexler M. … Patthy L. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 23
  2. Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules. (PMID: 11928817) Trexler M. … Patthy L. (Biol. Chem. 2002) 2 3 23
  3. Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. (PMID: 18596030) KondA!s K. … Patthy L. (J. Biol. Chem. 2008) 3 23
  4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  5. Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein. (PMID: 16791741) Liepinsh E. … Otting G. (J. Biomol. NMR 2006) 3 4

Products for WFIKKN1 Gene

Sources for WFIKKN1 Gene

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