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Aliases for WFIKKN1 Gene

Aliases for WFIKKN1 Gene

  • WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 1 2 3 5
  • WAP, Follistatin, Immunoglobulin, Kunitz And NTR Domain-Containing Protein 3 4
  • Growth And Differentiation Factor-Associated Serum Protein 2 3 4
  • WAP Four-Disulfide Core Domain 20A 2 3
  • C16orf12 3 4
  • HGASP-2 3 4
  • GASP-2 3 4
  • WFIKKN 3 4
  • WAP, Kazal, Immunoglobulin, Kunitz And NTR Domain-Containing Protein 1 3
  • WAP, FS, Ig, KU, And NTR-Containing Protein 3
  • Chromosome 16 Open Reading Frame 12 2
  • WFDC20A 3
  • GASP2 4
  • RJD2 3

External Ids for WFIKKN1 Gene

Previous HGNC Symbols for WFIKKN1 Gene

  • C16orf12

Previous GeneCards Identifiers for WFIKKN1 Gene

  • GC16P000622
  • GC16P000623
  • GC16P000680
  • GC16P000602
  • GC16P000681
  • GC16P000682
  • GC16P000683
  • GC16P000689

Summaries for WFIKKN1 Gene

Entrez Gene Summary for WFIKKN1 Gene

  • This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFIKKN1 Gene

WFIKKN1 (WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and metalloendopeptidase inhibitor activity. An important paralog of this gene is WFIKKN2.

UniProtKB/Swiss-Prot for WFIKKN1 Gene

  • Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity).

Gene Wiki entry for WFIKKN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFIKKN1 Gene

Genomics for WFIKKN1 Gene

Regulatory Elements for WFIKKN1 Gene

Enhancers for WFIKKN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F000586 1.5 FANTOM5 ENCODE 43 -38.1 -38108 8.4 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 WFIKKN1 RAB40C LOC105371038 ENSG00000261505 HBZP1 PRSS29P ENSG00000260051 ENSG00000260022 ENSG00000260954 NHLRC4
GH16F000628 1.1 ENCODE 55.1 +0.9 854 3.0 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 KLF13 ZNF263 SP3 WFIKKN1 RAB40C ENSG00000226890 HBZP1 PRSS29P IFT140 LOC105371038 RHBDL1 METTL26
GH16F000625 1 ENCODE 55.6 -2.4 -2414 1.9 SIN3A GLI4 ZNF2 GLIS2 FOS SMARCB1 SMARCA4 GLIS1 SP7 ZNF785 WFIKKN1 RAB40C WDR90 LOC105371038 ENSG00000261505 MPG ENSG00000260954 GC16M000614
GH16F000610 1.2 Ensembl ENCODE 42.8 -18.4 -18363 1.4 HDGF ARID4B SIN3A DMAP1 ZNF2 GLIS2 ZNF143 SP3 REST MBD2 WFIKKN1 RAB40C METTL26 NHLRC4 PIGQ WDR90 LOC105371038 PRR35 PIR61406 GC16P000603
GH16F000620 1.2 Ensembl ENCODE 42.2 -7.2 -7210 2.8 HDGF HDAC1 ATF1 PKNOX1 CREB3L1 NFRKB SIN3A RAD21 RFX5 GLIS2 WFIKKN1 RAB40C METTL26 FBXL16 GC16M000614
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WFIKKN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for WFIKKN1 Gene

Chromosome:
16
Start:
629,239 bp from pter
End:
634,116 bp from pter
Size:
4,878 bases
Orientation:
Plus strand

Genomic View for WFIKKN1 Gene

Genes around WFIKKN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFIKKN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFIKKN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFIKKN1 Gene

Proteins for WFIKKN1 Gene

  • Protein details for WFIKKN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NZ8-WFKN1_HUMAN
    Recommended name:
    WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
    Protein Accession:
    Q96NZ8
    Secondary Accessions:
    • Q7LDW0
    • Q8NBQ1
    • Q96S20

    Protein attributes for WFIKKN1 Gene

    Size:
    548 amino acids
    Molecular mass:
    58798 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK61237.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC11566.1; Type=Frameshift; Positions=147; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WFIKKN1 Gene

neXtProt entry for WFIKKN1 Gene

Post-translational modifications for WFIKKN1 Gene

  • Glycosylation at Asn 493
  • Modification sites at PhosphoSitePlus

Other Protein References for WFIKKN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFIKKN1 Gene

Domains & Families for WFIKKN1 Gene

Suggested Antigen Peptide Sequences for WFIKKN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NZ8

UniProtKB/Swiss-Prot:

WFKN1_HUMAN :
  • The second BPTI/Kunitz inhibitor domain is able to inhibit trypsin. It has however no activity toward chymotrypsin, elastase, plasmin, pancreatic kallikrein, lung tryptase, plasma kallikrein, thrombin, urokinase or tissue plasminogen activator.
  • Belongs to the WFIKKN family.
Domain:
  • The second BPTI/Kunitz inhibitor domain is able to inhibit trypsin. It has however no activity toward chymotrypsin, elastase, plasmin, pancreatic kallikrein, lung tryptase, plasma kallikrein, thrombin, urokinase or tissue plasminogen activator.
  • Contains 2 BPTI/Kunitz inhibitor domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Kazal-like domain.
  • Contains 1 NTR domain.
  • Contains 1 WAP domain.
Family:
  • Belongs to the WFIKKN family.
genes like me logo Genes that share domains with WFIKKN1: view

Function for WFIKKN1 Gene

Molecular function for WFIKKN1 Gene

UniProtKB/Swiss-Prot Function:
Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity).

Gene Ontology (GO) - Molecular Function for WFIKKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 23829672
GO:0008191 metalloendopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFIKKN1: view
genes like me logo Genes that share phenotypes with WFIKKN1: view

Animal Models for WFIKKN1 Gene

MGI Knock Outs for WFIKKN1:

Animal Model Products

  • Taconic Biosciences Mouse Models for WFIKKN1

miRNA for WFIKKN1 Gene

miRTarBase miRNAs that target WFIKKN1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WFIKKN1 Gene

Localization for WFIKKN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFIKKN1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFIKKN1 gene
Compartment Confidence
extracellular 5
plasma membrane 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for WFIKKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFIKKN1: view

Pathways & Interactions for WFIKKN1 Gene

SuperPathways for WFIKKN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WFIKKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0032091 negative regulation of protein binding IEA --
GO:0043392 negative regulation of DNA binding IEA --
genes like me logo Genes that share ontologies with WFIKKN1: view

No data available for Pathways by source and SIGNOR curated interactions for WFIKKN1 Gene

Transcripts for WFIKKN1 Gene

mRNA/cDNA for WFIKKN1 Gene

Unigene Clusters for WFIKKN1 Gene

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFIKKN1 Gene

No ASD Table

Relevant External Links for WFIKKN1 Gene

GeneLoc Exon Structure for
WFIKKN1
ECgene alternative splicing isoforms for
WFIKKN1

Expression for WFIKKN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WFIKKN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WFIKKN1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.5) and Brain - Cerebellar Hemisphere (x5.1).

Protein differential expression in normal tissues from HIPED for WFIKKN1 Gene

This gene is overexpressed in Monocytes (62.7) and Islet of Langerhans (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WFIKKN1 Gene



Protein tissue co-expression partners for WFIKKN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of WFIKKN1 Gene:

WFIKKN1

SOURCE GeneReport for Unigene cluster for WFIKKN1 Gene:

Hs.345818

mRNA Expression by UniProt/SwissProt for WFIKKN1 Gene:

Q96NZ8-WFKN1_HUMAN
Tissue specificity: Expressed in pancreas, kidney, liver, placenta, and lung.
genes like me logo Genes that share expression patterns with WFIKKN1: view

Primer Products

Orthologs for WFIKKN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for WFIKKN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WFIKKN1 34 35
  • 86.56 (n)
dog
(Canis familiaris)
Mammalia WFIKKN1 34 35
  • 86.5 (n)
mouse
(Mus musculus)
Mammalia Wfikkn1 34 16 35
  • 82.52 (n)
rat
(Rattus norvegicus)
Mammalia Wfikkn1 34
  • 82.46 (n)
oppossum
(Monodelphis domestica)
Mammalia WFIKKN1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves WFIKKN1 34 35
  • 76.89 (n)
lizard
(Anolis carolinensis)
Reptilia WFIKKN1 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wfikkn1 34
  • 60.67 (n)
zebrafish
(Danio rerio)
Actinopterygii wfikkn1 34 35
  • 64.44 (n)
worm
(Caenorhabditis elegans)
Secernentea mec-9 35
  • 10 (a)
ManyToMany
F22E12.1 35
  • 8 (a)
ManyToMany
ZK287.4 35
  • 7 (a)
ManyToMany
mec-1 35
  • 5 (a)
ManyToMany
Species where no ortholog for WFIKKN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WFIKKN1 Gene

ENSEMBL:
Gene Tree for WFIKKN1 (if available)
TreeFam:
Gene Tree for WFIKKN1 (if available)

Paralogs for WFIKKN1 Gene

Paralogs for WFIKKN1 Gene

(1) SIMAP similar genes for WFIKKN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFIKKN1: view

Variants for WFIKKN1 Gene

Sequence variations from dbSNP and Humsavar for WFIKKN1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10153076 -- 630,666(+) CGCTC(C/T)GCGGG upstream-variant-2KB
rs1058878 -- 634,486(+) GCTGA(A/G)AGCAC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs111471079 -- 631,741(+) ACCCC(A/T)TCACT intron-variant
rs111719210 -- 631,887(+) CATCC(A/T)CTTCT intron-variant
rs111991728 -- 631,588(+) TGTCT(-/TAAGAA)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFIKKN1 Gene

Variant ID Type Subtype PubMed ID
nsv952898 CNV deletion 24416366
nsv833114 CNV gain+loss 17160897
nsv571015 CNV loss 21841781
nsv571012 CNV loss 21841781
nsv526903 CNV loss 19592680
nsv516590 CNV loss 19592680
nsv471065 CNV gain 18288195
nsv471063 CNV loss 18288195
nsv1160326 CNV duplication 26073780
nsv1160325 CNV duplication 26073780
esv2750216 CNV deletion 23290073
esv2750214 CNV deletion 23290073
esv2422427 CNV duplication 17116639
dgv4824n54 CNV loss 21841781
dgv4823n54 CNV loss 21841781
dgv334n27 CNV loss 19166990
dgv315e201 CNV deletion 23290073

Variation tolerance for WFIKKN1 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WFIKKN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WFIKKN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFIKKN1 Gene

Disorders for WFIKKN1 Gene

Relevant External Links for WFIKKN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WFIKKN1

No disorders were found for WFIKKN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFIKKN1 Gene

Publications for WFIKKN1 Gene

  1. A human protein containing multiple types of protease-inhibitory modules. (PMID: 11274388) Trexler M. … Patthy L. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 22 64
  2. Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules. (PMID: 11928817) Trexler M. … Patthy L. (Biol. Chem. 2002) 2 3 22 64
  3. Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. (PMID: 18596030) KondA!s K. … Patthy L. (J. Biol. Chem. 2008) 3 22 64
  4. Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein. (PMID: 16791741) Liepinsh E. … Otting G. (J. Biomol. NMR 2006) 3 4 64
  5. Expression, purification and characterization of the second Kunitz- type protease inhibitor domain of the human WFIKKN protein. (PMID: 12709070) Nagy A. … Patthy L. (Eur. J. Biochem. 2003) 3 4 64

Products for WFIKKN1 Gene

Sources for WFIKKN1 Gene

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