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Aliases for WFDC9 Gene

Aliases for WFDC9 Gene

  • WAP Four-Disulfide Core Domain 9 2 3
  • WAP9 3 4
  • Protein WFDC9 3
  • DJ688G8.2 3

External Ids for WFDC9 Gene

Previous GeneCards Identifiers for WFDC9 Gene

  • GC20M043925
  • GC20M044875
  • GC20M044922
  • GC20M043669
  • GC20M044236
  • GC20M040978

Summaries for WFDC9 Gene

Entrez Gene Summary for WFDC9 Gene

  • The WAP-type four-disulfide core (WFDC) domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many members of the WFDC domain family. This gene encodes a protein which contains a WFDC domain, and is thus a member of the WFDC domain family. This gene and several other gene family members are clustered at 20q13.12. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC9 Gene

WFDC9 (WAP Four-Disulfide Core Domain 9) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC9 Gene

Genomics for WFDC9 Gene

Regulatory Elements for WFDC9 Gene

Genomic Location for WFDC9 Gene

45,607,939 bp from pter
45,631,268 bp from pter
23,330 bases
Minus strand

Genomic View for WFDC9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WFDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC9 Gene

Proteins for WFDC9 Gene

  • Protein details for WFDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein WFDC9
    Protein Accession:
    Secondary Accessions:
    • Q3MIX6
    • Q5TGZ8

    Protein attributes for WFDC9 Gene

    89 amino acids
    Molecular mass:
    10506 Da
    Quaternary structure:
    No Data Available
    • Although this protein was isolated in a region containing several WAP proteins and was defined as a WAP protein, it does not contain a classical WAP domain

neXtProt entry for WFDC9 Gene

Proteomics data for WFDC9 Gene at MOPED

Post-translational modifications for WFDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WFDC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC9 Gene

Domains for WFDC9 Gene

Gene Families for WFDC9 Gene

Protein Domains for WFDC9 Gene


Suggested Antigen Peptide Sequences for WFDC9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WFDC9: view

No data available for UniProtKB/Swiss-Prot for WFDC9 Gene

Function for WFDC9 Gene

Gene Ontology (GO) - Molecular Function for WFDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WFDC9: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC9

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC9 Gene

Localization for WFDC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC9 Gene


Subcellular locations from

Jensen Localization Image for WFDC9 Gene COMPARTMENTS Subcellular localization image for WFDC9 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for WFDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC9: view

Pathways for WFDC9 Gene

SuperPathways for WFDC9 Gene

No Data Available

Interacting Proteins for WFDC9 Gene

Selected Interacting proteins: Q8NEX5-WFDC9_HUMAN for WFDC9 Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for WFDC9 Gene


No data available for Pathways by source for WFDC9 Gene

Transcripts for WFDC9 Gene

mRNA/cDNA for WFDC9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC9 Gene

WAP four-disulfide core domain 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC9 Gene

No ASD Table

Relevant External Links for WFDC9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC9 Gene

mRNA expression in normal human tissues for WFDC9 Gene

SOURCE GeneReport for Unigene cluster for WFDC9 Gene Hs.249828

genes like me logo Genes that share expressions with WFDC9: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for WFDC9 Gene

Orthologs for WFDC9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for WFDC9 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC100685852 35
  • 77.15 (n)
  • 67.42 (a)
WFDC9 36
  • 67 (a)
(Mus musculus)
Mammalia Wfdc9 35
  • 68.29 (n)
  • 57.32 (a)
Wfdc9 16
Wfdc9 36
  • 55 (a)
(Pan troglodytes)
Mammalia WFDC9 35
  • 98.88 (n)
  • 96.63 (a)
WFDC9 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Wfdc9 35
  • 70.27 (n)
  • 62.16 (a)
(Bos Taurus)
Mammalia WFDC9 36
  • 57 (a)
Species with no ortholog for WFDC9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC9 Gene

Gene Tree for WFDC9 (if available)
Gene Tree for WFDC9 (if available)

Paralogs for WFDC9 Gene

(2) SIMAP similar genes for WFDC9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC9: view

No data available for Paralogs for WFDC9 Gene

Variants for WFDC9 Gene

Sequence variations from dbSNP and Humsavar for WFDC9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs190168 -- 45,618,210(+) tcagc(C/T)ttcat intron-variant
rs978778 -- 45,614,737(+) AAGAG(A/C)AGAAA intron-variant
rs978779 -- 45,614,903(+) TCTGA(A/T)AAGCT intron-variant
rs1487320 -- 45,608,348(-) TGGGC(C/G)CTCTA intron-variant
rs1487326 -- 45,619,416(-) ttgct(A/G)gatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC9 Gene

Variant ID Type Subtype PubMed ID
nsv7342 OTHER Inversion 18451855
nsv912893 CNV Loss 21882294

Relevant External Links for WFDC9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC9 Gene

Disorders for WFDC9 Gene

Relevant External Links for WFDC9

Genetic Association Database (GAD)

No disorders were found for WFDC9 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for WFDC9 Gene

Publications for WFDC9 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PMID: 15950183) Clauss A. … Lundwall A. (Biochem. Biophys. Res. Commun. 2005) 3
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3

Products for WFDC9 Gene

Sources for WFDC9 Gene

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