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Aliases for WFDC9 Gene

Aliases for WFDC9 Gene

  • WAP Four-Disulfide Core Domain 9 2 3 5
  • WAP9 3 4
  • Protein WFDC9 3
  • DJ688G8.2 3

External Ids for WFDC9 Gene

Previous GeneCards Identifiers for WFDC9 Gene

  • GC20M043925
  • GC20M044875
  • GC20M044922
  • GC20M043669
  • GC20M044236
  • GC20M040978

Summaries for WFDC9 Gene

Entrez Gene Summary for WFDC9 Gene

  • The WAP-type four-disulfide core (WFDC) domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many members of the WFDC domain family. This gene encodes a protein which contains a WFDC domain, and is thus a member of the WFDC domain family. This gene and several other gene family members are clustered at 20q13.12. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC9 Gene

WFDC9 (WAP Four-Disulfide Core Domain 9) is a Protein Coding gene. An important paralog of this gene is WFDC11.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC9 Gene

Genomics for WFDC9 Gene

Regulatory Elements for WFDC9 Gene

Enhancers for WFDC9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G045629 0.7 ENCODE 0.7 +1.6 1592 0.2 CTCF TRIM22 MAX RAD21 GATA3 ZNF366 SMC3 CREB1 ZNF143 ZNF24 WFDC10A WFDC9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WFDC9 on UCSC Golden Path with GeneCards custom track

Genomic Location for WFDC9 Gene

Chromosome:
20
Start:
45,607,939 bp from pter
End:
45,631,268 bp from pter
Size:
23,330 bases
Orientation:
Minus strand

Genomic View for WFDC9 Gene

Genes around WFDC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC9 Gene

Proteins for WFDC9 Gene

  • Protein details for WFDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEX5-WFDC9_HUMAN
    Recommended name:
    Protein WFDC9
    Protein Accession:
    Q8NEX5
    Secondary Accessions:
    • Q3MIX6
    • Q5TGZ8

    Protein attributes for WFDC9 Gene

    Size:
    89 amino acids
    Molecular mass:
    10506 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Although this protein was isolated in a region containing several WAP proteins and was defined as a WAP protein, it does not contain a classical WAP domain.

neXtProt entry for WFDC9 Gene

Post-translational modifications for WFDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WFDC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC9 Gene

Domains & Families for WFDC9 Gene

Gene Families for WFDC9 Gene

Protein Domains for WFDC9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WFDC9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WFDC9: view

No data available for UniProtKB/Swiss-Prot for WFDC9 Gene

Function for WFDC9 Gene

Phenotypes for WFDC9 Gene

genes like me logo Genes that share phenotypes with WFDC9: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC9 Gene

Localization for WFDC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC9 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for WFDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC9: view

Pathways & Interactions for WFDC9 Gene

SuperPathways for WFDC9 Gene

No Data Available

Interacting Proteins for WFDC9 Gene

Selected Interacting proteins: Q8NEX5-WFDC9_HUMAN for WFDC9 Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for WFDC9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WFDC9 Gene

Transcripts for WFDC9 Gene

mRNA/cDNA for WFDC9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC9 Gene

WAP four-disulfide core domain 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC9 Gene

No ASD Table

Relevant External Links for WFDC9 Gene

GeneLoc Exon Structure for
WFDC9
ECgene alternative splicing isoforms for
WFDC9

Expression for WFDC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WFDC9 Gene

NURSA nuclear receptor signaling pathways regulating expression of WFDC9 Gene:

WFDC9

SOURCE GeneReport for Unigene cluster for WFDC9 Gene:

Hs.249828

Evidence on tissue expression from TISSUES for WFDC9 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with WFDC9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WFDC9 Gene

Orthologs for WFDC9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for WFDC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WFDC9 34 35
  • 98.88 (n)
dog
(Canis familiaris)
Mammalia LOC100685852 34
  • 77.15 (n)
WFDC9 35
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wfdc9 34
  • 70.27 (n)
mouse
(Mus musculus)
Mammalia Wfdc9 34 16 35
  • 68.29 (n)
cow
(Bos Taurus)
Mammalia WFDC9 35
  • 57 (a)
OneToOne
Species where no ortholog for WFDC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC9 Gene

ENSEMBL:
Gene Tree for WFDC9 (if available)
TreeFam:
Gene Tree for WFDC9 (if available)

Paralogs for WFDC9 Gene

Paralogs for WFDC9 Gene

(2) SIMAP similar genes for WFDC9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC9: view

Variants for WFDC9 Gene

Sequence variations from dbSNP and Humsavar for WFDC9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000004976 -- 45,617,776(+) GCACC(A/G)TCATG intron-variant
rs1000050999 -- 45,631,896(+) TCCTT(A/G)TCTTT upstream-variant-2KB
rs1000105092 -- 45,624,351(+) CAGAA(C/T)ATAAT intron-variant
rs1000119134 -- 45,630,272(+) GACGG(C/T)AGGTG intron-variant
rs1000402050 -- 45,631,554(+) CTCCT(C/T)AGCCT downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WFDC9 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958
nsv586081 CNV loss 21841781
nsv7342 OTHER inversion 18451855

Variation tolerance for WFDC9 Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WFDC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WFDC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC9 Gene

Disorders for WFDC9 Gene

Relevant External Links for WFDC9

Genetic Association Database (GAD)
WFDC9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WFDC9

No disorders were found for WFDC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC9 Gene

Publications for WFDC9 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z. … Hurle B. (Mol. Biol. Evol. 2013) 3 64

Products for WFDC9 Gene

Sources for WFDC9 Gene

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