WFDC8 Gene
protein-coding GIFtS: 43
GCID: GC20M044179
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WAP four-disulfide core domain 8(Previous name: chromosome 20 open reading frame 170 )
(Previous symbol: C20orf170)
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Aliases
for WFDC8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WAP Four-Disulfide Core Domain 81 2 | | Chromosome 20 Open Reading Frame 1701 | | C20orf1701 2 3 | | Protease Inhibitor WAP82 | | WAP81 2 3 | | WAP Four-Disulfide Core Domain Protein 82 | | DJ461P17.11 | | WAP Motif Protein 12 | | Putative Protease Inhibitor WAP82 3 | | |
Export aliases for WFDC8 gene to outside databasesPrevious GC identifers: GC20M043868 GC20M044818 GC20M044865 GC20M043613 GC20M040921 |
Summaries
for WFDC8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WFDC8:
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signaturemotif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a proteaseinhibitor. The encoded protein contains a Kunitz-inhibitor domain, in addition to three WFDC domains. Most WFDC genesare localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomericcluster. Two alternatively spliced transcript variants have been found for this gene, and they encode the sameprotein. (provided by RefSeq, Jul 2008)
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Genomic Views
for WFDC8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WFDC8 gene promoter:
HNF-1 HFH-1 Hand1 HNF-1A E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for WFDC8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.11WFDC8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M044179: view genomic region
(about GC identifiers)
Start:
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44,179,791 bp from pter |
End:
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44,207,965 bp from pter |
Size:
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28,175 bases |
Orientation:
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minus strand |
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Proteins
for WFDC8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WFDC8_HUMAN, Q8IUA0 (See
protein sequence)Recommended Name: WAP four-disulfide core domain protein 8 precursor Size: 241 amino acids; 27824 Da
Subcellular location: Secreted (Potential)
Secondary accessions: E1P623 Q5TDV2 Q96A34Explore the universe of human proteins at neXtProt for WFDC8: NX_Q8IUA0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IUA0
WFDC8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_570966.2 NP_852611.2
ENSEMBL proteins: ENSP00000361735 ENSP00000289953
Human Recombinant Protein Products for WFDC8:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
WFDC8 for ontologies About GeneDecksing
WFDC8 Antibody Products:
Assay Products for WFDC8: |
Protein
Domains /
Families
for WFDC8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WFDC8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IUA0ProtoNet protein and cluster: Q8IUA0 2 Blocks protein families: IPB002223 Pancreatic trypsin inhibitor (Kunitz) IPB008197 4-disulphide core signature
UniProtKB/Swiss-Prot: WFDC8_HUMAN, Q8IUA0Similarity: Contains 1 BPTI/Kunitz inhibitor domainSimilarity: Contains 3 WAP domains |
Function
for WFDC8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity |
IEA | -- |
WFDC8 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for WFDC8:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC8 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for WFDC8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC8 |
|
Pathways & Interactions
for WFDC8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFDC8
|
Drugs & Compounds
for WFDC8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WFDC8
Search CenterWatch for drugs/clinical trials and news about WFDC8
|
Transcripts
for WFDC8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WFDC8 gene (2 alternative transcripts): NM_130896.2 NM_181510.2 Unigene Cluster for WFDC8: WAP four-disulfide core domain 8 Hs.116128 [show with all ESTs]Unigene Representative Sequence: NM_1815102 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357199(uc002xow.3) ENST00000289953(uc002xox.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC8 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): WFDC8 (NM_130896) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WFDC8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC8 |
Additional cDNA sequence: AF492015.1 AF492016.1 AL591715.1 3 DOTS entries: DT.100010346 DT.100010347 DT.92421145 24/25 AceView cDNA sequences (see all 25): AL449565 AL591715 AL449558 AA885204 AL133571 NM_130896 AL449579 AL449578 NM_181510 BX105539 AF492016 AI208729 AF492015 AL449564 AA626150 AL449581 AL449577 AL449592 AL449587 AL449593 AL449560 AL449589 AL449583 AL449591
GeneLoc Exon Structure
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Expression
for WFDC8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WFDC8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See WFDC8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WFDC8
SOURCE GeneReport for Unigene cluster: Hs.116128
UniProtKB/Swiss-Prot: WFDC8_HUMAN, Q8IUA0Tissue specificity: Expressed ubiquitously, the highest levels are found in the epididymis followed by testis andtrachea
SABiosciences Custom PCR Arrays for WFDC8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WFDC8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC8 |
Orthologs
for WFDC8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WFDC8 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for WFDC8 (if available)
TreeFam Gene Tree for WFDC8 (if available) |
Paralogs
for WFDC8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WFDC8 gene
- AMBP2 SPINT32 TFPI2 WFIKKN12 SPINT22 WFIKKN22 TFPI22 EPPIN2
- EPPIN-WFDC62
6 SIMAP similar genes for WFDC8 using alignment to 1 protein entry: WFDC8_HUMAN:SPINT3 WFDC12 ITIL EPPIN SPINT4 TFPI2
WFDC8 for paralogs About GeneDecksing
|
Genomic Variants
for WFDC8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WFDC8 (44179791 - 44207965 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for WFDC8
2 CNVs: 67699 7306
1 Indel: 59025 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC8 |
|
Disorders
/ Diseases
for WFDC8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WFDC8 for disorders About GeneDecksing
1  disease for WFDC8: About MalaCardspancreatitis
Export disorders for WFDC8 gene to outside databases
|
Publications
for WFDC8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WFDC8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WFDC8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 2, 3 Clauss A.... Lundwall A. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Differing evolutionary histories of WFDC8 (short-term balancing) in Europeans and SPINT4 (incomplete selective sweep) in Africans. (PubMed id 21536719)1 Ferreira Z....Seixas S. (2011)
- The evolution of a genetic locus encoding small serine proteinase inhibitors. (PubMed id 15950183)1 Clauss A....Lundwall A. (2005)
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External Searches for WFDC8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing WFDC8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WFDC8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WFDC8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WFDC8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WFDC8 gene:
Search GeneIP for patents involving WFDC8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WFDC8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WFDC8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WFDC8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC8 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WFDC8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | WFDC8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC8 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC8 |
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