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Aliases for WFDC6 Gene

Aliases for WFDC6 Gene

  • WAP Four-Disulfide Core Domain 6 2 3 5
  • C20orf171 3 4
  • WAP6 3 4
  • Chromosome 20 Open Reading Frame 171 2
  • Epididymis Secretory Protein Li 295 3
  • Putative Protease Inhibitor WAP6 4
  • Protease Inhibitor WAP6 3
  • DJ461P17.11 3
  • HEL-S-295 3

External Ids for WFDC6 Gene

Previous HGNC Symbols for WFDC6 Gene

  • C20orf171

Previous GeneCards Identifiers for WFDC6 Gene

  • GC20M043851
  • GC20M044801
  • GC20M044848
  • GC20M043596
  • GC20M044162
  • GC20M040904

Summaries for WFDC6 Gene

Entrez Gene Summary for WFDC6 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for WFDC6 Gene

WFDC6 (WAP Four-Disulfide Core Domain 6) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. An important paralog of this gene is WFDC8.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC6 Gene

Genomics for WFDC6 Gene

Regulatory Elements for WFDC6 Gene

Enhancers for WFDC6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WFDC6 on UCSC Golden Path with GeneCards custom track

Genomic Location for WFDC6 Gene

45,534,196 bp from pter
45,539,495 bp from pter
5,300 bases
Minus strand

Genomic View for WFDC6 Gene

Genes around WFDC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC6 Gene

Proteins for WFDC6 Gene

  • Protein details for WFDC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 6
    Protein Accession:
    Secondary Accessions:
    • Q3MJ23
    • Q5JYQ4
    • Q8NFV6

    Protein attributes for WFDC6 Gene

    131 amino acids
    Molecular mass:
    14626 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WFDC6 Gene


neXtProt entry for WFDC6 Gene

Proteomics data for WFDC6 Gene at MOPED

Post-translational modifications for WFDC6 Gene

No Post-translational modifications

Other Protein References for WFDC6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC6 Gene

Domains & Families for WFDC6 Gene

Gene Families for WFDC6 Gene

Protein Domains for WFDC6 Gene

Suggested Antigen Peptide Sequences for WFDC6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BPTI/Kunitz inhibitor domain.
  • Contains 1 BPTI/Kunitz inhibitor domain.
  • Contains 1 WAP domain.
genes like me logo Genes that share domains with WFDC6: view

Function for WFDC6 Gene

Phenotypes for WFDC6 Gene

GenomeRNAi human phenotypes for WFDC6:
genes like me logo Genes that share phenotypes with WFDC6: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WFDC6 Gene

Localization for WFDC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC6 Gene

Subcellular locations from

Jensen Localization Image for WFDC6 Gene COMPARTMENTS Subcellular localization image for WFDC6 gene
Compartment Confidence
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for WFDC6 Gene

Pathways & Interactions for WFDC6 Gene

SuperPathways for WFDC6 Gene

No Data Available

Interacting Proteins for WFDC6 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000361755 for WFDC6 Gene via STRING

Gene Ontology (GO) - Biological Process for WFDC6 Gene


No data available for Pathways by source and SIGNOR curated interactions for WFDC6 Gene

Drugs & Compounds for WFDC6 Gene

No Compound Related Data Available

Transcripts for WFDC6 Gene

mRNA/cDNA for WFDC6 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(54) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC6 Gene

WAP four-disulfide core domain 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC6 Gene

No ASD Table

Relevant External Links for WFDC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC6 Gene

mRNA expression in normal human tissues for WFDC6 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC6 Gene

This gene is overexpressed in Testis (x45.5).

Protein differential expression in normal tissues from HIPED for WFDC6 Gene

This gene is overexpressed in Testis (53.4) and Ovary (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WFDC6 Gene

SOURCE GeneReport for Unigene cluster for WFDC6 Gene Hs.673237

mRNA Expression by UniProt/SwissProt for WFDC6 Gene

Tissue specificity: Ubiquitously expressed, but the highest levels are found in epididymis, testis and trachea.
genes like me logo Genes that share expression patterns with WFDC6: view

Protein tissue co-expression partners for WFDC6 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for WFDC6 Gene

Orthologs for WFDC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for WFDC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia WFDC6 36
  • 32 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 16 (a)
(Mus musculus)
Mammalia Wfdc6a 36
  • 34 (a)
Wfdc6b 36
  • 28 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 11 (a)
-- 36
  • 13 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 12 (a)
-- 36
  • 12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3604 36
  • 7 (a)
(Caenorhabditis elegans)
Secernentea R12A1.3 36
  • 5 (a)
Species with no ortholog for WFDC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for WFDC6 Gene

Gene Tree for WFDC6 (if available)
Gene Tree for WFDC6 (if available)

Paralogs for WFDC6 Gene

Paralogs for WFDC6 Gene

(1) SIMAP similar genes for WFDC6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WFDC6: view

Variants for WFDC6 Gene

Sequence variations from dbSNP and Humsavar for WFDC6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2143224 -- 45,533,846(+) actcc(C/T)gacct downstream-variant-500B
rs2143225 -- 45,533,861(+) tgatc(C/T)gccct downstream-variant-500B
rs3746593 -- 45,534,210(+) ACAGA(A/G)CACTT utr-variant-3-prime
rs2206446 -- 45,534,570(+) TCTTG(C/G)ACCTA intron-variant
rs6032274 -- 45,535,349(+) CAGAA(C/T)AGAGC intron-variant

Variation tolerance for WFDC6 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for WFDC6 Gene

Disorders for WFDC6 Gene

Relevant External Links for WFDC6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WFDC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC6 Gene

Publications for WFDC6 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3 4 67
  2. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z. … Hurle B. (Mol. Biol. Evol. 2013) 3
  3. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PMID: 15950183) Clauss A. … Lundwall A. (Biochem. Biophys. Res. Commun. 2005) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3

Products for WFDC6 Gene

Sources for WFDC6 Gene