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Aliases for WFDC5 Gene

Aliases for WFDC5 Gene

  • WAP Four-Disulfide Core Domain 5 2 3 5
  • Putative Protease Inhibitor WAP1 3 4
  • P53-Responsive Gene 5 Protein 3 4
  • PRG5 3 4
  • WAP1 3 4
  • WAP Four-Disulfide Core Domain Protein 5 3
  • Protease Inhibitor WAP1 3
  • DJ211D12.5 3

External Ids for WFDC5 Gene

Previous GeneCards Identifiers for WFDC5 Gene

  • GC20M043426
  • GC20M044376
  • GC20M044423
  • GC20M043171
  • GC20M043738
  • GC20M040479

Summaries for WFDC5 Gene

Entrez Gene Summary for WFDC5 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC5 Gene

WFDC5 (WAP Four-Disulfide Core Domain 5) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.

UniProtKB/Swiss-Prot for WFDC5 Gene

  • Putative acid-stable proteinase inhibitor.

Gene Wiki entry for WFDC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC5 Gene

Genomics for WFDC5 Gene

Regulatory Elements for WFDC5 Gene

Enhancers for WFDC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F045153 0.3 FANTOM5 11.3 -37.6 -37627 0.1 ZNF639 ZNF175 MAX GABPA FOSL1 ZNF589 ZKSCAN8 IRF1 ZNF584 SPI1 WFDC5 SYS1 LOC101929863 PI3
GH20F045154 0.2 Ensembl 11.3 -37.3 -37281 0.4 ZNF639 ZNF175 GABPA FOSL1 ZNF589 JUND ZKSCAN8 IRF1 ZNF584 SLPI WFDC5 LOC101929863 PI3
GH20F045138 0.2 ENCODE 11.2 -22.4 -22380 1.3 CTCF TFAP4 CBX3 PKNOX1 ZNF175 ZBTB40 RAD21 SMC3 ZNF143 NR2F6 SLPI WFDC5 LOC101929863 WFDC12
GH20F045068 1 Ensembl ENCODE 11 +45.6 45580 3.7 PKNOX1 ATF1 FEZF1 BRCA1 ELK1 GATA2 FOS DEK NCOA1 TSHZ1 KCNS1 WFDC5 STK4 PIR48188 ENSG00000252021
GH20F045066 0.2 ENCODE 11 +48.6 48577 1.8 JUND PBX2 STAT3 KCNS1 WFDC5 STK4 PIR48188 ENSG00000252021
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WFDC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for WFDC5 Gene

45,109,452 bp from pter
45,116,321 bp from pter
6,870 bases
Minus strand

Genomic View for WFDC5 Gene

Genes around WFDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC5 Gene

Proteins for WFDC5 Gene

  • Protein details for WFDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 5
    Protein Accession:
    Secondary Accessions:
    • Q5H981
    • Q6UWE4

    Protein attributes for WFDC5 Gene

    224 amino acids
    Molecular mass:
    24238 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WFDC5 Gene


neXtProt entry for WFDC5 Gene

Post-translational modifications for WFDC5 Gene

No Post-translational modifications

Other Protein References for WFDC5 Gene

No data available for DME Specific Peptides for WFDC5 Gene

Domains & Families for WFDC5 Gene

Gene Families for WFDC5 Gene

Protein Domains for WFDC5 Gene

Suggested Antigen Peptide Sequences for WFDC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 WAP domains.
  • Contains 2 WAP domains.
genes like me logo Genes that share domains with WFDC5: view

Function for WFDC5 Gene

Molecular function for WFDC5 Gene

UniProtKB/Swiss-Prot Function:
Putative acid-stable proteinase inhibitor.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Gene Ontology (GO) - Molecular Function for WFDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFDC5: view
genes like me logo Genes that share phenotypes with WFDC5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WFDC5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC5 Gene

Localization for WFDC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC5 Gene


Subcellular locations from

Jensen Localization Image for WFDC5 Gene COMPARTMENTS Subcellular localization image for WFDC5 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for WFDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC5: view

Pathways & Interactions for WFDC5 Gene

SuperPathways for WFDC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WFDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with WFDC5: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC5 Gene

Transcripts for WFDC5 Gene

mRNA/cDNA for WFDC5 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC5 Gene

WAP four-disulfide core domain 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC5 Gene

No ASD Table

Relevant External Links for WFDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC5 Gene

mRNA expression in normal human tissues for WFDC5 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x25.8) and Skin - Not Sun Exposed (Suprapubic) (x25.2).

NURSA nuclear receptor signaling pathways regulating expression of WFDC5 Gene:


SOURCE GeneReport for Unigene cluster for WFDC5 Gene:

genes like me logo Genes that share expression patterns with WFDC5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for WFDC5 Gene

Orthologs for WFDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WFDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WFDC5 34 35
  • 99.19 (n)
(Canis familiaris)
Mammalia WFDC5 34 35
  • 79.95 (n)
(Bos Taurus)
Mammalia WFDC5 34 35
  • 79.06 (n)
(Rattus norvegicus)
Mammalia Wfdc5 34
  • 76.96 (n)
(Mus musculus)
Mammalia Wfdc5 34 16 35
  • 74.53 (n)
(Monodelphis domestica)
Mammalia WFDC5 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia WFDC5 35
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
-- 35
  • 34 (a)
-- 35
  • 32 (a)
-- 35
  • 31 (a)
-- 35
  • 28 (a)
Species where no ortholog for WFDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC5 Gene

Gene Tree for WFDC5 (if available)
Gene Tree for WFDC5 (if available)

Paralogs for WFDC5 Gene

(1) SIMAP similar genes for WFDC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC5: view

No data available for Paralogs for WFDC5 Gene

Variants for WFDC5 Gene

Sequence variations from dbSNP and Humsavar for WFDC5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111436767 -- 45,110,375(+) GCACC(A/T)GCCCT intron-variant
rs111660564 -- 45,110,753(+) TCATC(C/T)GGCGG reference, synonymous-codon
rs111728580 -- 45,116,939(+) AAGTG(C/G)TGGGA upstream-variant-2KB
rs111992595 -- 45,110,414(+) GATCC(C/T)GGCAA reference, missense
rs112248539 -- 45,111,336(+) TGTGA(C/T)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC5 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958

Variation tolerance for WFDC5 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WFDC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC5 Gene

Disorders for WFDC5 Gene

Relevant External Links for WFDC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WFDC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC5 Gene

Publications for WFDC5 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. (PMID: 10680116) Ranganathan S. … Nicholas K.R. (J. Mol. Graph. Model. 1999) 2 3 64

Products for WFDC5 Gene

Sources for WFDC5 Gene

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