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WFDC5 Gene

protein-coding   GIFtS: 45
GCID: GC20M043738

WAP Four-Disulfide Core Domain 5

  Search for WFDC5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WAP Four-Disulfide Core Domain 51 2     P53-Responsive Gene 5 Protein2 3
PRG52 3 5     dJ211D12.52
WAP12 3 5     Protease Inhibitor WAP12
Putative Protease Inhibitor WAP12 3     WAP Four-Disulfide Core Domain Protein 52

External Ids:    HGNC: 204771   Entrez Gene: 1497082   Ensembl: ENSG000001751217   OMIM: 6051615   UniProtKB: Q8TCV53   

Export aliases for WFDC5 gene to outside databases

Previous GC identifers: GC20M043426 GC20M044376 GC20M044423 GC20M043171 GC20M040479


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WFDC5 Gene:
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain
only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature
motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a
protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and
telomeric. This gene belongs to the centromeric cluster. (provided by RefSeq, Jul 2008)

GeneCards Summary for WFDC5 Gene:
WFDC5 (WAP four-disulfide core domain 5) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot: WFDC5_HUMAN, Q8TCV5
Function: Putative acid-stable proteinase inhibitor

Gene Wiki entry for WFDC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the WFDC5 gene promoter:
         STAT1   STAT1beta   RelA   NF-kappaB   C/EBPalpha   STAT1alpha   POU2F1   POU2F1a   NF-kappaB1   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWFDC5 promoter sequence
   Search Chromatin IP Primers for WFDC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WFDC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.11

WFDC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WFDC5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043738:  view genomic region     (about GC identifiers)

Start:
43,738,093 bp from pter      End:
43,743,813 bp from pter
Size:
5,721 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WFDC5_HUMAN, Q8TCV5 (See protein sequence)
Recommended Name: WAP four-disulfide core domain protein 5 precursor  
Size: 224 amino acids; 24238 Da
Secondary accessions: Q5H981 Q6UWE4
Alternative splicing: 2 isoforms:  Q8TCV5-1   Q8TCV5-2   (Gene prediction confirmed by EST data)

Explore the universe of human proteins at neXtProt for WFDC5: NX_Q8TCV5

Explore proteomics data for WFDC5 at MOPED


See WFDC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_663627.1  
ENSEMBL proteins: 
 ENSP00000312381   ENSP00000361875  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
WFDC: WAP four-disulfide core domain containing

1 InterPro protein domain:
 IPR008197 WAP-type_4-diS_core

Graphical View of Domain Structure for InterPro Entry Q8TCV5

ProtoNet protein and cluster: Q8TCV5

1 Blocks protein domain: IPB008197 4-disulphide core signature

UniProtKB/Swiss-Prot: WFDC5_HUMAN, Q8TCV5
Similarity: Contains 2 WAP domains


WFDC5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: WFDC5_HUMAN, Q8TCV5
Function: Putative acid-stable proteinase inhibitor
Induction: By p53/TP53

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004867serine-type endopeptidase inhibitor activity IEA--
GO:0030414peptidase inhibitor activity ----
     
WFDC5 for ontologies           About GeneDecksing


Phenotypes:
     1 MGI phenotypic allele for Wfdc5 (no phenotypes)

WFDC5 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Wfdc5tm1Lex for WFDC5

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WFDC5
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
WFDC5_HUMAN, Q8TCV5: Secreted (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

WFDC5 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WFDC5
Interactions:

    Search GeneGlobe Interaction Network for WFDC5

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for WFDC5 (Q8TCV53 ENSP000003618754) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
PDS5AQ29RF73, ENSP000003034274I2D: score=1 STRING: ENSP00000303427
SMC1AQ146833, ENSP000003234214I2D: score=1 STRING: ENSP00000323421
SMC3Q9UQE73, ENSP000003547204I2D: score=1 STRING: ENSP00000354720
STAG1Q8WVM73, ENSP000003726894I2D: score=1 STRING: ENSP00000372689
PDS5BQ9NTI53, ENSP000003138514I2D: score=1 STRING: ENSP00000313851
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for WFDC5



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for WFDC5 gene: 
NM_145652.3  

Unigene Cluster for WFDC5:

WAP four-disulfide core domain 5
Hs.375031  [show with all ESTs]
Unigene Representative Sequence: BC039173
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000307971 ENST00000372789(uc002xne.2)
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Additional mRNA sequence: 

AY038181.1 AY358822.1 BC039173.1 

1 DOTS entry:

DT.70104508 

9 AceView cDNA sequences:

NM_145652 BC039173 AI307134 BG675206 AY358822 AI242082 AY038181 BF353401 
AF147078 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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WFDC5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATTTTCACCA
WFDC5 Expression
About this image

WFDC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

WFDC5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.375031
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for WFDC5 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Wfdc51 , 5 WAP four-disulfide core domain 51, 5 74.53(n)1
67.48(a)1
  2 (84.60 cM)5
2092321  NM_145369.31  NP_663344.21 
 1641763275 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 5)
Uncharacterized protein
(see all 5)
36(a)
34(a)
(see all 5)
many → 1
many → 1
(see all 5)
4(143216887-143224592)
4(143178017-143184282)


ENSEMBL Gene Tree for WFDC5 (if available)
TreeFam Gene Tree for WFDC5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for WFDC5 gene
1 SIMAP similar gene for WFDC5 using alignment to 1 protein entry:     WFDC5_HUMAN:
SLPI

WFDC5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for WFDC5 (see all 207)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1409582991,2
--43737652(+) CAGCAC/TTTTGG 1 -- ds50010--------
rs573580181,2
C--43737725(+) AAAACC/TTGTCT 1 -- ds50010--------
rs1901315081,2
--43737754(+) TTAGCA/CAGGCA 1 -- ds50010--------
rs1513384681,2
C--43737809(+) AGAAGA/TATCGC 1 -- ds50010--------
rs1930695321,2
C--43737833(+) ACGGAA/GGTTGC 1 -- ds50010--------
rs1394122611,2
C--43738039(+) CTGTTG/TCCATT 1 -- ds50010--------
rs61307531,2
C,F,H--43738168(+) GTAAAT/CGGTGG 1 -- ut31 ese319Minor allele frequency- C:0.13NS EA NA 2228
rs1129244581,2
C,F--43738183(+) GGCAGC/TGTGCA 1 -- ut310--------
rs1147817381,2
C,F--43738184(+) GCAGCG/ATGCAA 1 -- ut311Minor allele frequency- A:0.03WA 118
rs1905109931,2
--43738241(+) GTGAAC/TGACTG 1 -- ut310--------

HapMap Linkage Disequilibrium report for WFDC5 (43738093 - 43743813 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for WFDC5: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing WFDC5
DNA2.0 Custom Variant and Variant Library Synthesis for WFDC5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605161    OMIM disorders: --


WFDC5 for disorders           About GeneDecksing


Export disorders for WFDC5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for WFDC5 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with WFDC5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 2, 3 Clauss A.... Lundwall A. (Biochem. J. 2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
  5. The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. (PubMed id 10680116)1, 3 Ranganathan S....Nicholas K.R. (amp 1999)
  6. Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. (PubMed id 10441517)1, 2 Horikoshi N.... Shenk T. (Biochem. Biophys. Res. Commun. 1999)
  7. Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin. (PubMed id 19906707)1 Bauerschmidt C....Rothkamm K. (Nucleic Acids Res. 2010)
  8. The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells. (PubMed id 17511965)1 Mukhopadhyay S.S. and Rosen J.M. (Biochem. Biophys. Res. Commun. 2007)
  9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  10. Human Wapl is a cohesin-binding protein that promotes sister- chromatid resolution in mitotic prophase. (PubMed id 17112726)1 Gandhi R.... Hirano T. (Curr. Biol. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 149708 HGNC: 20477 AceView: WFDC5 Ensembl:ENSG00000175121 euGenes: HUgn149708
ECgene: WFDC5 H-InvDB: WFDC5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for WFDC5 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WFDC5 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for WFDC5 gene:
Search GeneIP for patents involving WFDC5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WFDC5
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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