WFDC5 Gene
protein-coding GIFtS: 45
GCID: GC20M043738
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|
WAP four-disulfide core domain 5
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Aliases
for WFDC5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WAP Four-Disulfide Core Domain 51 2 | | Putative Protease Inhibitor WAP12 3 | | WAP11 2 3 5 | | P53-Responsive Gene 5 Protein2 3 | | PRG52 3 5 | | Protease Inhibitor WAP12 | | DJ211D12.51 | | WAP Four-Disulfide Core Domain Protein 52 |
Export aliases for WFDC5 gene to outside databasesPrevious GC identifers: GC20M043426 GC20M044376 GC20M044423 GC20M043171 GC20M040479 |
Summaries
for WFDC5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WFDC5:
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain onlyone WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, containseight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. MostWFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongsto the centromeric cluster. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: WFDC5_HUMAN, Q8TCV5Function: Putative acid-stable proteinase inhibitor
Gene Wiki entry for WFDC5
|
Genomic Views
for WFDC5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WFDC5 gene promoter:
STAT1 STAT1beta RelA NF-kappaB C/EBPalpha STAT1alpha POU2F1 POU2F1a NF-kappaB1 AP-2alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for WFDC5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.11WFDC5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M043738: view genomic region
(about GC identifiers)
Start:
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43,738,093 bp from pter |
End:
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43,743,813 bp from pter |
Size:
|
5,721 bases |
Orientation:
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minus strand |
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Proteins
for WFDC5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WFDC5_HUMAN, Q8TCV5 (See
protein sequence)Recommended Name: WAP four-disulfide core domain protein 5 precursor Size: 224 amino acids; 24238 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q5H981 Q6UWE4Alternative splicing: 2 isoforms: Q8TCV5-1 Q8TCV5-2 (Gene prediction confirmed by EST data)Explore the universe of human proteins at neXtProt for WFDC5: NX_Q8TCV5
WFDC5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_663627.1
ENSEMBL proteins: ENSP00000312381 ENSP00000361875
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
WFDC5 for ontologies About GeneDecksing
WFDC5 Antibody Products:
Assay Products for WFDC5: |
Protein
Domains /
Families
for WFDC5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WFDC5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TCV5ProtoNet protein and cluster: Q8TCV5 1 Blocks protein family: IPB008197 4-disulphide core signature
UniProtKB/Swiss-Prot: WFDC5_HUMAN, Q8TCV5Similarity: Contains 2 WAP domains |
Function
for WFDC5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WFDC5_HUMAN, Q8TCV5Function: Putative acid-stable proteinase inhibitorInduction: By p53/TP53
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity |
IEA | -- |
WFDC5 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Wfdc5tm1Lex for WFDC5
1 MGI phenotypic allele  for Wfdc5 (no phenotypes)
WFDC5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for WFDC5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFDC5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for WFDC5 (Q8TCV53 ENSP000003618754) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for WFDC5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WFDC5
Search CenterWatch for drugs/clinical trials and news about WFDC5
|
Transcripts
for WFDC5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WFDC5 gene: NM_145652.3 Unigene Cluster for WFDC5: WAP four-disulfide core domain 5 Hs.375031 [show with all ESTs]Unigene Representative Sequence: BC0391732 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000307971 ENST00000372789(uc002xne.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WFDC5 (NM_145652) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WFDC5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC5 |
Additional cDNA sequence: AY038181.1 AY358822.1 BC039173.1 1 DOTS entry: DT.70104508 9 AceView cDNA sequences: NM_145652 BC039173 AY358822 AY038181 AI242082 BG675206 AI307134 BF353401 AF147078
GeneLoc Exon Structure
|
Expression
for WFDC5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WFDC5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTTCACCA
About this image
See WFDC5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WFDC5
SOURCE GeneReport for Unigene cluster: Hs.375031
SABiosciences Custom PCR Arrays for WFDC5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WFDC5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC5 |
Orthologs
for WFDC5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WFDC5 gene from 1/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
20(a) |
1 → many |
Group5.25(83189-83923) |
ENSEMBL Gene Tree for WFDC5 (if available)
TreeFam Gene Tree for WFDC5 (if available) |
Paralogs
for WFDC5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WFDC5 gene
- WFDC32 WFDC22 SLPI2
1 SIMAP similar gene for WFDC5 using alignment to 1 protein entry: WFDC5_HUMAN:SLPI
WFDC5 for paralogs About GeneDecksing
|
Genomic Variants
for WFDC5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WFDC5 (43738093 - 43743813 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WFDC5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC5 |
|
Disorders
/ Diseases
for WFDC5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 WFDC5 for disorders About MalaCards
WFDC5 for disorders About GeneDecksing
OMIM gene information: 605161
OMIM disorders: --
Export disorders for WFDC5 gene to outside databases
|
Publications
for WFDC5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WFDC5 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with WFDC5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 2, 3 Clauss A.... Lundwall A. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. (PubMed id 10680116)1, 3 Ranganathan S....Nicholas K.R. (1999)
- Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. (PubMed id 10441517)1, 2 Horikoshi N.... Shenk T. (1999)
- Cohesin promotes the repair of ionizing radiation-ind uced DNA double-strand breaks in replicated chromatin. (PubMed id 19906707)1 Bauerschmidt C....Rothkamm K. (2010)
- The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells. (PubMed id 17511965)1 Mukhopadhyay S.S. and Rosen J.M. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. (PubMed id 17112726)1 Gandhi R....Hirano T. (2006)
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External Searches for WFDC5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WFDC5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WFDC5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WFDC5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for WFDC5 gene:
Search GeneIP for patents involving WFDC5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WFDC5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WFDC5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WFDC5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC5 |
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| |  |  |  |  | | | | |
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 | | | WFDC5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC5 |
|  |  |  | | | | ThermoFisher Antibody for WFDC5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC5 |
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