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Aliases for WFDC5 Gene

Aliases for WFDC5 Gene

  • WAP Four-Disulfide Core Domain 5 2 3
  • Putative Protease Inhibitor WAP1 3 4
  • P53-Responsive Gene 5 Protein 3 4
  • PRG5 3 4
  • WAP1 3 4
  • Protease Inhibitor WAP1 3
  • DJ211D12.5 3

External Ids for WFDC5 Gene

Previous GeneCards Identifiers for WFDC5 Gene

  • GC20M043426
  • GC20M044376
  • GC20M044423
  • GC20M043171
  • GC20M043738
  • GC20M040479

Summaries for WFDC5 Gene

Entrez Gene Summary for WFDC5 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC5 Gene

WFDC5 (WAP Four-Disulfide Core Domain 5) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.

UniProtKB/Swiss-Prot for WFDC5 Gene

  • Putative acid-stable proteinase inhibitor

Gene Wiki entry for WFDC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC5 Gene

Genomics for WFDC5 Gene

Genomic Location for WFDC5 Gene

45,109,452 bp from pter
45,116,321 bp from pter
6,870 bases
Minus strand

Genomic View for WFDC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WFDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC5 Gene

Proteins for WFDC5 Gene

  • Protein details for WFDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 5
    Protein Accession:
    Secondary Accessions:
    • Q5H981
    • Q6UWE4

    Protein attributes for WFDC5 Gene

    224 amino acids
    Molecular mass:
    24238 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WFDC5 Gene


neXtProt entry for WFDC5 Gene

Proteomics data for WFDC5 Gene at MOPED

Post-translational modifications for WFDC5 Gene

No Post-translational modifications

Other Protein References for WFDC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WFDC5 Gene

Domains & Families for WFDC5 Gene

Gene Families for WFDC5 Gene

Protein Domains for WFDC5 Gene


Suggested Antigen Peptide Sequences for WFDC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 WAP domains.
  • Contains 2 WAP domains.
genes like me logo Genes that share domains with WFDC5: view

Function for WFDC5 Gene

Molecular function for WFDC5 Gene

UniProtKB/Swiss-Prot Function:
Putative acid-stable proteinase inhibitor
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Gene Ontology (GO) - Molecular Function for WFDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity --
genes like me logo Genes that share ontologies with WFDC5: view

Phenotypes for WFDC5 Gene

GenomeRNAi human phenotypes for WFDC5:
genes like me logo Genes that share phenotypes with WFDC5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC5 Gene

Localization for WFDC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC5 Gene


Subcellular locations from

Jensen Localization Image for WFDC5 Gene COMPARTMENTS Subcellular localization image for WFDC5 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for WFDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC5: view

Pathways & Interactions for WFDC5 Gene

SuperPathways for WFDC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WFDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with WFDC5: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC5 Gene

Drugs & Compounds for WFDC5 Gene

No Compound Related Data Available

Transcripts for WFDC5 Gene

mRNA/cDNA for WFDC5 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC5 Gene

WAP four-disulfide core domain 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC5 Gene

No ASD Table

Relevant External Links for WFDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC5 Gene

mRNA expression in normal human tissues for WFDC5 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x25.8) and Skin - Not Sun Exposed (Suprapubic) (x25.2).

SOURCE GeneReport for Unigene cluster for WFDC5 Gene Hs.375031

genes like me logo Genes that share expression patterns with WFDC5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for WFDC5 Gene

Orthologs for WFDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WFDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WFDC5 35
  • 79.06 (n)
  • 74.38 (a)
WFDC5 36
  • 70 (a)
(Canis familiaris)
Mammalia WFDC5 35
  • 79.95 (n)
  • 72.36 (a)
WFDC5 36
  • 60 (a)
(Mus musculus)
Mammalia Wfdc5 35
  • 74.53 (n)
  • 67.48 (a)
Wfdc5 16
Wfdc5 36
  • 66 (a)
(Pan troglodytes)
Mammalia WFDC5 35
  • 99.19 (n)
  • 100 (a)
WFDC5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wfdc5 35
  • 76.96 (n)
  • 69.92 (a)
(Monodelphis domestica)
Mammalia WFDC5 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia WFDC5 36
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
-- 36
  • 28 (a)
-- 36
  • 36 (a)
-- 36
  • 31 (a)
-- 36
  • 32 (a)
Species with no ortholog for WFDC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC5 Gene

Gene Tree for WFDC5 (if available)
Gene Tree for WFDC5 (if available)

Paralogs for WFDC5 Gene

(1) SIMAP similar genes for WFDC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC5: view

No data available for Paralogs for WFDC5 Gene

Variants for WFDC5 Gene

Sequence variations from dbSNP and Humsavar for WFDC5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs734685 -- 45,112,882(-) TGCCT(A/G)TTTAT intron-variant
rs763058 -- 45,112,843(-) TAACT(A/C)TCTGA intron-variant
rs2157360 -- 45,111,849(+) TGAGT(C/G)TCCAC intron-variant
rs6017491 -- 45,113,797(+) GGTAA(A/G)GTGAA intron-variant
rs6017492 -- 45,113,802(+) AGTGA(A/G)TCTTT intron-variant

Variation tolerance for WFDC5 Gene

Residual Variation Intolerance Score: 53.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WFDC5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for WFDC5 Gene

Disorders for WFDC5 Gene

Relevant External Links for WFDC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WFDC5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC5 Gene

Publications for WFDC5 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 67
  2. The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. (PMID: 10680116) Ranganathan S. … Nicholas K.R. (J. Mol. Graph. Model. 1999) 2 67
  3. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z. … Hurle B. (Mol. Biol. Evol. 2013) 67
  4. Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin. (PMID: 19906707) Bauerschmidt C. … Rothkamm K. (Nucleic Acids Res. 2010) 67
  5. The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells. (PMID: 17511965) Mukhopadhyay S.S. … Rosen J.M. (Biochem. Biophys. Res. Commun. 2007) 67

Products for WFDC5 Gene

Sources for WFDC5 Gene

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