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WFDC3 Gene

protein-coding   GIFtS: 46
GCID: GC20M044377

WAP Four-Disulfide Core Domain 3

  Search for WFDC3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
WAP Four-Disulfide Core Domain 31 2     Protease Inhibitor WAP142
Putative Protease Inhibitor WAP142 3     WAP Four-Disulfide Core Domain Protein 32
WAP142 3     Whey Acidic Protein 142
dJ447F3.32     

External Ids:    HGNC: 159571   Entrez Gene: 1406862   Ensembl: ENSG000001241167   UniProtKB: Q8IUB23   
ORGUL members:         

Export aliases for WFDC3 gene to outside databases

Previous GC identifers: GC20M044131 GC20M045041 GC20M045088 GC20M043836 GC20M041144


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WFDC3 Gene:
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP
signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions
as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to
chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster.
Alternatively spliced transcript variants have been observed but their full-length nature has not been
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for WFDC3 Gene:
WFDC3 (WAP four-disulfide core domain 3) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the WFDC3 gene promoter:
         Max1   AML1a   GATA-3   Pax-2   Pax-2a   GATA-2   GATA-1   c-Rel   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWFDC3 promoter sequence
   Search Chromatin IP Primers for WFDC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WFDC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

WFDC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WFDC3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044377:  view genomic region     (about GC identifiers)

Start:
44,376,583 bp from pter      End:
44,420,571 bp from pter
Size:
43,989 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WFDC3_HUMAN, Q8IUB2 (See protein sequence)
Recommended Name: WAP four-disulfide core domain protein 3 precursor  
Size: 231 amino acids; 24687 Da
Sequence caution: Sequence=AAI02014.1; Type=Erroneous initiation; Sequence=AAI02015.1; Type=Erroneous initiation;
Secondary accessions: A6PVF2 Q0P6A5 Q3T1C5 Q8TC52 Q9BQP3 Q9BQP4

Explore the universe of human proteins at neXtProt for WFDC3: NX_Q8IUB2

Explore proteomics data for WFDC3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn107, Asn217

  • See WFDC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_542181.1  
    ENSEMBL proteins: 
     ENSP00000337815   ENSP00000243938   ENSP00000361715   ENSP00000361713  

    WFDC3 Human Recombinant Protein Products:

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    WFDC3 Assay Products:

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    Cloud-Clone Corp. ELISAs for WFDC3
    Cloud-Clone Corp. CLIAs for WFDC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WFDC: WAP four-disulfide core domain containing

    1 InterPro protein domain:
     IPR008197 WAP-type_4-diS_core

    Graphical View of Domain Structure for InterPro Entry Q8IUB2

    ProtoNet protein and cluster: Q8IUB2

    1 Blocks protein domain: IPB008197 4-disulphide core signature

    UniProtKB/Swiss-Prot: WFDC3_HUMAN, Q8IUB2
    Similarity: Contains 4 WAP domains


    WFDC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0030414peptidase inhibitor activity ----
         
    WFDC3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Wfdc3 (no phenotypes)

    WFDC3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WFDC3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WFDC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WFDC3

    miRNA
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    miRTarBase miRNAs that target WFDC3:
    hsa-mir-335-5p (MIRT018314)

    Block miRNA regulation of human, mouse, rat WFDC3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate WFDC3:
    hsa-miR-4323
    SwitchGear 3'UTR luciferase reporter plasmidWFDC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WFDC3
    Predesigned siRNA for gene silencing in human, mouse, rat WFDC3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: WFDC3 (NM_080614)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WFDC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WFDC3_HUMAN, Q8IUB2: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    WFDC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WFDC3
    Interactions:

        Search GeneGlobe Interaction Network for WFDC3

    1 Interacting protein for WFDC3 (Q8IUB22) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --P310162MINT-8107029
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WFDC3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WFDC3 gene (4 alternative transcripts): 
    NM_080614.1  NM_181522.1  NM_181525.1  NM_181530.1  

    Unigene Cluster for WFDC3:

    WAP four-disulfide core domain 3
    Hs.419126  [show with all ESTs]
    Unigene Representative Sequence: NM_080614
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481847 ENST00000337205 ENST00000243938(uc002xpf.1 uc002xpj.1 uc002xph.1 uc010ghh.1)
    ENST00000474942 ENST00000372632 ENST00000372630 ENST00000471401 ENST00000493693
    ENST00000487343 ENST00000462017 ENST00000467679 ENST00000490877 ENST00000465935

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WFDC3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate WFDC3:
    hsa-miR-4323
    SwitchGear 3'UTR luciferase reporter plasmidWFDC3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WFDC3
    Predesigned siRNA for gene silencing in human, mouse, rat WFDC3
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    OriGene ORF clones in mouse, rat for WFDC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WFDC3 (NM_080614)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WFDC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC3
    Primer
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    OriGene qPCR primer pairs and template standards for WFDC3
    OriGene qSTAR qPCR primer pairs in human, mouse for WFDC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat WFDC3
      QuantiTect SYBR Green Assays in human, mouse, rat WFDC3
      QuantiFast Probe-based Assays in human, mouse, rat WFDC3

    Additional mRNA sequence: 

    AF488306.1 AL591713.1 BC026014.1 BC102013.1 BC102014.1 

    7 DOTS entries:

    DT.100009331  DT.97831689  DT.100009332  DT.120817217  DT.95102994  DT.65286346  DT.99927584 

    23 AceView cDNA sequences:

    NM_181522 NM_181530 NM_181525 BF002489 AL591713 NM_080614 BM727641 AW448916 
    BI912742 BM701270 AF488306 CB111238 AI985094 BC026014 BI460167 BX091378 
    CD511978 BM716782 AI243277 AL449629 CD102193 BF197609 AA536130 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WFDC3 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
    SP1:              -     -                       -     -     -     -                                                   
    SP2:              -     -     -                 -     -     -     -                                                   
    SP3:                                                        -     -                                                   
    SP4:              -     -     -     -           -     -     -     -     -                                             
    SP5:                                      -     -     -     -     -     -                                             


    ECgene alternative splicing isoforms for WFDC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WFDC3 expression in normal human tissues (normalized intensities)      WFDC3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAATAGCC
    WFDC3 Expression
    About this image


    WFDC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
    WFDC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WFDC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.419126

    UniProtKB/Swiss-Prot: WFDC3_HUMAN, Q8IUB2
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for WFDC3 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wfdc35 WAP four-disulfide core domain 3   --   2 (85.27 cM) 164731180 


    ENSEMBL Gene Tree for WFDC3 (if available)
    TreeFam Gene Tree for WFDC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WFDC3 gene
    2 SIMAP similar genes for WFDC3 using alignment to 4 protein entries:     WFDC3_HUMAN (see all proteins):
    EPPIN    KAL1

    WFDC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WFDC3
    PGOHUM00000259564


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WFDC3 (see all 371)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404267761,2
    Cuntested144405812(+) CACACG/AGAAGG 2 /P /L mis11Minor allele frequency- A:0.00NA 4548
    rs60739061,2
    C,F,A,H--41144192(+) AGGCAC/TGGTAG 1 -- ds50017Minor allele frequency- T:0.20NA WA CSA 15
    rs1486930041,2
    C--41144193(+) GGCATA/GGTAGC 1 -- ds50010--------
    rs1422419001,2
    --44402364(+) ATTGCA/GCCACT 1 -- ds50010--------
    rs587421531,2
    --44402457(+) CCACAG/TTCTCC 1 -- ds50010--------
    rs622150161,2
    C,F--44402686(+) TTCCAC/TCCATC 1 -- ds50016Minor allele frequency- T:0.40WA NA CSA EA 364
    rs1853487021,2
    --44402761(+) CTGTCA/CTAAAT 1 -- ds50010--------
    rs1902018241,2
    --44402853(+) GAGGTC/TAGCAC 1 -- ut310--------
    rs26645291,2
    C,F,A,H--44402869(+) TTTATT/CGGGAA 1 -- ut31 ese335Minor allele frequency- C:0.37NS NA EA WA CSA 3299
    rs731227201,2
    C,F--44402970(+) GAGTGC/TCCCTG 1 -- ut311Minor allele frequency- T:0.16NA 120

    HapMap Linkage Disequilibrium report for WFDC3 (44376583 - 44420571 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WFDC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722452CNV Deletion23290073
    nsv833990CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WFDC3
    DNA2.0 Custom Variant and Variant Library Synthesis for WFDC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WFDC3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with WFDC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 2, 3 Clauss A.... Lundwall A. (Biochem. J. 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    4. The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. (PubMed id 10680116)1, 3 Ranganathan S....Nicholas K.R. (amp 1999)
    5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    6. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PubMed id 15950183)1 Clauss A....Lundwall A. (Biochem. Biophys. Res. Commun. 2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a single whey acidic protein motif. (PubMed id 12574366)9 Hagiwara K....Nukiwa T. (J. Immunol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140686 HGNC: 15957 AceView: WFDC3 Ensembl:ENSG00000124116 euGenes: HUgn140686
    ECgene: WFDC3 H-InvDB: WFDC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WFDC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WFDC3 gene:
    Search GeneIP for patents involving WFDC3

    GeneCards and IP:
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