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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WFDC3 Gene

protein-coding GIFtS: 43
GCID: GC20M044377

WAP four-disulfide core domain 3

Search for WFDC3
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
WAP Four-Disulfide Core Domain 3¹ ²		Protease Inhibitor WAP14²
WAP14¹ ² ³		WAP Four-Disulfide Core Domain Protein 3²
DJ447F3.3¹		Whey Acidic Protein 14²
Putative Protease Inhibitor WAP14² ³

External Ids:	HGNC: 15957¹	Entrez Gene: 140686²	Ensembl: ENSG00000124116⁷	UniProtKB: Q8IUB2³

Export aliases for WFDC3 gene to outside databases

Previous GC identifers: GC20M044131 GC20M045041 GC20M045088 GC20M043836 GC20M041144

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WFDC3:

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature

motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease

inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in

two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript

variants have been observed but their full-length nature has not been determined. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WFDC3 gene promoter:
Max1 AML1a GATA-3 Pax-2 Pax-2a GATA-2 GATA-1 c-Rel c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WFDC3 promoter sequence

Search SABiosciences Chromatin IP Primers for WFDC3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12

WFDC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WFDC3 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M044377: view genomic region (about GC identifiers)

Start:	44,376,583 bp from pter	End:	44,420,571 bp from pter
Size:	43,989 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WFDC3_HUMAN, Q8IUB2 (See protein sequence)

Recommended Name: WAP four-disulfide core domain protein 3 precursor

Size: 231 amino acids; 24687 Da

Subcellular location: Secreted (Potential)

Sequence caution: Sequence=AAI02014.1; Type=Erroneous initiation; Sequence=AAI02015.1; Type=Erroneous initiation;

Secondary accessions: A6PVF2 Q0P6A5 Q3T1C5 Q8TC52 Q9BQP3 Q9BQP4

Explore the universe of human proteins at neXtProt for WFDC3: NX_Q8IUB2

WFDC3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_542181.1

ENSEMBL proteins:

ENSP00000337815 ENSP00000243938 ENSP00000361715 ENSP00000361713

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

WFDC3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WFDC3 for domains About GeneDecksing

2 InterPro domains/families:

IPR008197 Whey_acidic_protein_4-diS_core

IPR015874 4-disulphide_core

Graphical View of Domain Structure for InterPro Entry Q8IUB2

ProtoNet protein and cluster: Q8IUB2

1 Blocks protein family: IPB008197 4-disulphide core signature

UniProtKB/Swiss-Prot: WFDC3_HUMAN, Q8IUB2

Similarity: Contains 4 WAP domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone: WFDC3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WFDC3
		1 QIAGEN miScript miRNA Assays for microRNA that regulate WFDC3:
		hsa-miR-4323
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	--
GO:0030414	peptidase inhibitor activity	--	--

WFDC3 for ontologies About GeneDecksing

Animal Models:
1 MGI phenotypic allele

for Wfdc3 (no phenotypes)

WFDC3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for WFDC3

1 Interacting protein for WFDC3 (Q8IUB2²) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
--	P31016²	MINT-8107029

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WFDC3
Search CenterWatch for drugs/clinical trials and news about WFDC3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WFDC3 gene (4 alternative transcripts):

NM_080614.1 NM_181522.1 NM_181525.1 NM_181530.1

Unigene Cluster for WFDC3:

WAP four-disulfide core domain 3

Hs.419126 [show with all ESTs]

Unigene Representative Sequence: NM_080614

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000481847 ENST00000337205 ENST00000243938(uc002xpf.1 uc002xpj.1 uc002xph.1 uc010ghh.1)

ENST00000474942 ENST00000372632 ENST00000372630 ENST00000471401 ENST00000493693

ENST00000487343 ENST00000462017 ENST00000467679 ENST00000490877 ENST00000465935

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate WFDC3:
		hsa-miR-4323
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AF488306.1 AL591713.1 BC026014.1 BC102013.1 BC102014.1

7 DOTS entries:

DT.100009331 DT.97831689 DT.100009332 DT.120817217 DT.95102994 DT.65286346 DT.99927584

23 AceView cDNA sequences:

BF002489 BM727641 NM_080614 NM_181525 AL591713 NM_181522 NM_181530 AI985094

AW448916 CB111238 BM701270 BI912742 AF488306 BC026014 BX091378 BI460167

BM716782 AI243277 CD511978 AL449629 CD102193 AA536130 BF197609

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for WFDC3 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	·	10d	·	10e	·	10f
SP1:					-		-								-		-		-		-
SP2:					-		-		-						-		-		-		-
SP3:																			-		-
SP4:					-		-		-		-				-		-		-		-		-
SP5:													-		-		-		-		-		-

ECgene alternative splicing isoforms for WFDC3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WFDC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAATAGCC

About this image

WFDC3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See WFDC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WFDC3

SOURCE GeneReport for Unigene cluster: Hs.419126

UniProtKB/Swiss-Prot: WFDC3_HUMAN, Q8IUB2

Tissue specificity: Ubiquitously expressed

SABiosciences Custom PCR Arrays for WFDC3

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for WFDC3 gene from 5/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Wfdc3⁵	WAP four-disulfide core domain 3	--		2 (85.27 cM) 164731180
chicken (Gallus gallus)	Aves	WFDC2¹	WAP four-disulfide core domain 2	51.38(n) 42.04(a)		419300 XM_417472.3 XP_417472.3
lizard (Anolis carolinensis)	Reptilia	WFDC2⁶ -- (see all 4)	--	29(a) 29(a) (see all 4)	possible ortholog possible ortholog (see all 4)	GL343690.1(232632-241056) GL344356.1(11630-17177)
zebrafish (Danio rerio)	Actinopterygii	wfdc2¹	WAP four-disulfide core domain 2	41.84(n) 32.41(a)		556600 XM_679439.4 XP_684531.2
honey bee (Apis mellifera)	Insecta	--	--	18(a)	1 → many	Group5.25(83189-83923)

ENSEMBL Gene Tree for WFDC3 (if available)
TreeFam Gene Tree for WFDC3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WFDC3 gene

WFDC2² WFDC5² SLPI²

2 SIMAP similar genes for WFDC3 using alignment to 4 protein entries: WFDC3_HUMAN (see all proteins):

EPPIN KAL1

WFDC3 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for WFDC3
PGOHUM00000259564

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140426776^1,2	C	other	44405812(+)	`CACACG/AGAAGG`	2	/P /L	mis¹		1		NA	4548
rs78254036^1,2	C,	--	41153518(+)	`ACACTA/CTATGA`	1	--	int¹		0	--	--	--	--
rs142241900^1,2		--	44402364(+)	`ATTGCA/GCCACT`	1	--	ds500¹		0	--	--	--	--
rs58742153^1,2		--	44402457(+)	`CCACAG/TTCTCC`	1	--	ds500¹		0	--	--	--	--
rs62215016^1,2	C,F,	--	44402686(+)	`TTCCAC/TCCATC`	1	--	ds500¹		6		WA NA CSA EA	364
rs185348702^1,2		--	44402761(+)	`CTGTCA/CTAAAT`	1	--	ds500¹		0	--	--	--	--
rs190201824^1,2		--	44402853(+)	`GAGGTC/TAGCAC`	1	--	ut3¹		0	--	--	--	--
rs2664529^1,2	C,F,A,H,	--	44402869(+)	`TTTATT/CGGGAA`	1	--	ut3¹ ese³		35		NS NA EA WA CSA	3299
rs73122720^1,2	C,F,	--	44402970(+)	`GAGTGC/TCCCTG`	1	--	ut3¹		1		NA	120
rs149882811^1,2	C,F,	--	44403076(+)	`GGCACC/TGGGAT`	2	P	syn¹		2		NA EU	5867

HapMap Linkage Disequilibrium report for WFDC3 (44376583 - 44420571 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WFDC3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC3

DNA2.0 Custom Variant and Variant Library Synthesis for WFDC3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WFDC3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WFDC3)

Utopia: connect your pdf to the dynamic
world of online information

A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)^{1, 2, 3} Clauss A.... Lundwall A. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. (PubMed id 10680116)^{1, 3} Ranganathan S....Nicholas K.R. (1999)
The evolution of a genetic locus encoding small serine proteinase inhibitors. (PubMed id 15950183)¹ Clauss A....Lundwall A. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a single whey acidic protein motif. (PubMed id 12574366)⁹ Hagiwara K....Nukiwa T. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 140686	HGNC: 15957	AceView: WFDC3	Ensembl:ENSG00000124116	euGenes: HUgn140686
ECgene: WFDC3	H-InvDB: WFDC3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WFDC3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WFDC3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WFDC3 gene:
Search GeneIP for patents involving WFDC3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for WFDC3
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WFDC3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WFDC3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC3
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	GenScript Custom Purified and Recombinant Proteins Services for WFDC3		GenScript cDNA clones with any tag delivered in your preferred vector for WFDC3
	GenScript Custom Assay Services for WFDC3		GenScript Custom Superior Antibodies Services for WFDC3
	GenScript Custom overexpressing Cell Line Services for WFDC3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes WFDC3 gene at Home site.

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WFDC3 Gene

WAP four-disulfide core domain 3

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WFDC3 Gene

WAP four-disulfide core domain 3

Aliasesfor WFDC3 gene

Summariesfor WFDC3 gene

Genomic Viewsfor WFDC3 gene

Proteinsfor WFDC3 gene

Protein Domains /Familiesfor WFDC3 gene

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