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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WFDC3 Gene

protein-coding   GIFtS: 42
GCID: GC20M044377

WAP Four-Disulfide Core Domain 3

  Search for WFDC3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WAP Four-Disulfide Core Domain 31 2     Protease Inhibitor WAP142
Putative Protease Inhibitor WAP142 3     WAP Four-Disulfide Core Domain Protein 32
WAP142 3     Whey Acidic Protein 142
dJ447F3.32     

External Ids:    HGNC: 159571   Entrez Gene: 1406862   Ensembl: ENSG000001241167   UniProtKB: Q8IUB23   

Export aliases for WFDC3 gene to outside databases

Previous GC identifers: GC20M044131 GC20M045041 GC20M045088 GC20M043836 GC20M041144


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WFDC3 Gene:
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP
signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions
as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to
chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster.
Alternatively spliced transcript variants have been observed but their full-length nature has not been
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for WFDC3 Gene: 
WFDC3 (WAP four-disulfide core domain 3) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WFDC3 gene promoter:
         Max1   AML1a   GATA-3   Pax-2   Pax-2a   GATA-2   GATA-1   c-Rel   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWFDC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for WFDC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

WFDC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WFDC3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044377:  view genomic region     (about GC identifiers)

Start:
44,376,583 bp from pter      End:
44,420,571 bp from pter
Size:
43,989 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WFDC3_HUMAN, Q8IUB2 (See protein sequence)
Recommended Name: WAP four-disulfide core domain protein 3 precursor  
Size: 231 amino acids; 24687 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=AAI02014.1; Type=Erroneous initiation; Sequence=AAI02015.1; Type=Erroneous initiation;
Secondary accessions: A6PVF2 Q0P6A5 Q3T1C5 Q8TC52 Q9BQP3 Q9BQP4

Explore the universe of human proteins at neXtProt for WFDC3: NX_Q8IUB2

Explore proteomics data for WFDC3 at MOPED 

WFDC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

WFDC3 Protein Expression

REFSEQ proteins: NP_542181.1  
ENSEMBL proteins: 
 ENSP00000337815   ENSP00000243938   ENSP00000361715   ENSP00000361713  

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Cloud-Clone Corp. Proteins for WFDC3 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

WFDC3 for ontologies           About GeneDecksing



WFDC3 Antibody Products: 
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Cloud-Clone Corp. CLIAs for WFDC3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
WFDC: WAP four-disulfide core domain containing

1 InterPro protein domain:
 IPR008197 WAP-type_4-diS_core

Graphical View of Domain Structure for InterPro Entry Q8IUB2

ProtoNet protein and cluster: Q8IUB2

1 Blocks protein domain: IPB008197 4-disulphide core signature

UniProtKB/Swiss-Prot: WFDC3_HUMAN, Q8IUB2
Similarity: Contains 4 WAP domains


WFDC3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004867serine-type endopeptidase inhibitor activity IEA--
GO:0030414peptidase inhibitor activity ----
     
WFDC3 for ontologies           About GeneDecksing


Phenotypes:
     1 MGI phenotypic allele for Wfdc3 (no phenotypes)

WFDC3 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for WFDC3 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WFDC3 
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miRNA
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1 QIAGEN miScript miRNA Assays for microRNA that regulate WFDC3:
hsa-miR-4323
SwitchGear 3'UTR luciferase reporter plasmidWFDC3 3' UTR sequence
Inhib. RNA
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Gene Editing
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFDC3

1 Interacting protein for WFDC3 (Q8IUB22) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
--P310162MINT-8107029
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WFDC3

Search CenterWatch for drugs/clinical trials and news about WFDC3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WFDC3 gene (4 alternative transcripts): 
NM_080614.1  NM_181522.1  NM_181525.1  NM_181530.1  

Unigene Cluster for WFDC3:

WAP four-disulfide core domain 3
Hs.419126  [show with all ESTs]
Unigene Representative Sequence: NM_080614
13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000481847 ENST00000337205 ENST00000243938(uc002xpf.1 uc002xpj.1 uc002xph.1 uc010ghh.1)
ENST00000474942 ENST00000372632 ENST00000372630 ENST00000471401 ENST00000493693
ENST00000487343 ENST00000462017 ENST00000467679 ENST00000490877 ENST00000465935

miRNA
Products:
     
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1 QIAGEN miScript miRNA Assays for microRNA that regulate WFDC3:
hsa-miR-4323
SwitchGear 3'UTR luciferase reporter plasmidWFDC3 3' UTR sequence
Inhib. RNA
Products:
     
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OriGene RNAi products in human, mouse, rat for WFDC3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WFDC3
Clone
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OriGene clones in human, mouse for WFDC3 (see all 9)
OriGene ORF clones in mouse, rat for WFDC3
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GenScript: all cDNA clones in your preferred vector: WFDC3 (NM_080614)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for WFDC3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC3
Sirion Biotech Customized lentivirus for stable overexpression of WFDC3 
                     Customized lentivirus expression plasmids for stable overexpression of WFDC3 
Primer
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OriGene qPCR primer pairs and template standards for WFDC3
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SABiosciences RT2 qPCR Primer Assay in human, mouse / rat WFDC3
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC3

Additional mRNA sequence: 

AF488306.1 AL591713.1 BC026014.1 BC102013.1 BC102014.1 

7 DOTS entries:

DT.100009331  DT.97831689  DT.100009332  DT.120817217  DT.95102994  DT.65286346  DT.99927584 

23 AceView cDNA sequences:

BM727641 BF002489 NM_181530 AL591713 NM_181522 NM_181525 NM_080614 BI912742 
AI985094 CB111238 AW448916 AF488306 BM701270 BM716782 BC026014 AI243277 
BX091378 BI460167 CD511978 AL449629 AA536130 CD102193 BF197609 

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for WFDC3 (see all 9)    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1:              -     -                       -     -     -     -                                                   
SP2:              -     -     -                 -     -     -     -                                                   
SP3:                                                        -     -                                                   
SP4:              -     -     -     -           -     -     -     -     -                                             
SP5:                                      -     -     -     -     -     -                                             


ECgene alternative splicing isoforms for WFDC3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WFDC3 expression in normal human tissues (normalized intensities)      WFDC3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAAATAGCC
WFDC3 Expression
About this image


WFDC3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Testis (Reproductive System)
         sperm   
 
 Liver (Hepatobiliary System)
         Human Mesenchymal Stem Cell-hepatic (HMSC-he)   
 
 Blood (Hematopoietic System)
         Proerythroblasts Hematopoietic Bone Marrow
 
 Mesenchymal Stem Cells
         Human Mesenchymal Stem Cell-hepatic (HMSC-he)   

See WFDC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WFDC3

SOURCE GeneReport for Unigene cluster: Hs.419126

UniProtKB/Swiss-Prot: WFDC3_HUMAN, Q8IUB2
Tissue specificity: Ubiquitously expressed

    SABiosciences Custom PCR Arrays for WFDC3
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for WFDC3 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Wfdc35 WAP four-disulfide core domain 3   --   2 (85.27 cM) 164731180 
chicken
(Gallus gallus)
Aves WFDC21 WAP four-disulfide core domain 2 51.38(n)
42.04(a)
  419300  XM_417472.3  XP_417472.3 
zebrafish
(Danio rerio)
Actinopterygii wfdc21 WAP four-disulfide core domain 2 41.84(n)
32.41(a)
  556600  XM_679439.4  XP_684531.2 


ENSEMBL Gene Tree for WFDC3 (if available)
TreeFam Gene Tree for WFDC3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for WFDC3 gene
2 SIMAP similar genes for WFDC3 using alignment to 4 protein entries:     WFDC3_HUMAN (see all proteins):
EPPIN    KAL1

WFDC3 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for WFDC3
PGOHUM00000259564


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/371 SNPs in WFDC3 are shown (see all 371)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1404267761,2
Cuntested144405812(+) CACACG/AGAAGG 2 /P /L mis11Minor allele frequency- A:0.00NA 4548
rs60739061,2
C,F,A,H--41144192(+) AGGCAC/TGGTAG 1 -- ds50017Minor allele frequency- T:0.20NA WA CSA 15
rs1486930041,2
C--41144193(+) GGCATA/GGTAGC 1 -- ds50010--------
rs1422419001,2
--44402364(+) ATTGCA/GCCACT 1 -- ds50010--------
rs587421531,2
--44402457(+) CCACAG/TTCTCC 1 -- ds50010--------
rs622150161,2
C,F--44402686(+) TTCCAC/TCCATC 1 -- ds50016Minor allele frequency- T:0.40WA NA CSA EA 364
rs1853487021,2
--44402761(+) CTGTCA/CTAAAT 1 -- ds50010--------
rs1902018241,2
--44402853(+) GAGGTC/TAGCAC 1 -- ut310--------
rs26645291,2
C,F,A,H--44402869(+) TTTATT/CGGGAA 1 -- ut31 ese335Minor allele frequency- C:0.37NS NA EA WA CSA 3299
rs731227201,2
C,F--44402970(+) GAGTGC/TCCCTG 1 -- ut311Minor allele frequency- T:0.16NA 120

HapMap Linkage Disequilibrium report for WFDC3 (44376583 - 44420571 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for WFDC3:    About this table     
Variant IDTypeSubtypePubMed ID
esv2722452CNV Deletion23290073
nsv833990CNV Loss17160897

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing WFDC3
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for WFDC3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WFDC3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 2, 3 Clauss A.... Lundwall A. (2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  4. The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. (PubMed id 10680116)1, 3 Ranganathan S....Nicholas K.R. (1999)
  5. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
  6. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PubMed id 15950183)1 Clauss A....Lundwall A. (2005)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a single whey acidic protein motif. (PubMed id 12574366)9 Hagiwara K....Nukiwa T. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 140686 HGNC: 15957 AceView: WFDC3 Ensembl:ENSG00000124116 euGenes: HUgn140686
ECgene: WFDC3 H-InvDB: WFDC3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for WFDC3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for WFDC3 gene:
Search GeneIP for patents involving WFDC3

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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