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Aliases for WFDC3 Gene

Aliases for WFDC3 Gene

  • WAP Four-Disulfide Core Domain 3 2 3
  • Putative Protease Inhibitor WAP14 3 4
  • WAP14 3 4
  • WAP Four-Disulfide Core Domain Protein 3 3
  • Protease Inhibitor WAP14 3
  • Whey Acidic Protein 14 3
  • DJ447F3.3 3

External Ids for WFDC3 Gene

Previous GeneCards Identifiers for WFDC3 Gene

  • GC20M044131
  • GC20M045041
  • GC20M045088
  • GC20M043836
  • GC20M044377
  • GC20M041144

Summaries for WFDC3 Gene

Entrez Gene Summary for WFDC3 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC3 Gene

WFDC3 (WAP Four-Disulfide Core Domain 3) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC3 Gene

Genomics for WFDC3 Gene

Regulatory Elements for WFDC3 Gene

Genomic Location for WFDC3 Gene

45,747,944 bp from pter
45,791,932 bp from pter
43,989 bases
Minus strand

Genomic View for WFDC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WFDC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC3 Gene

Proteins for WFDC3 Gene

  • Protein details for WFDC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 3
    Protein Accession:
    Secondary Accessions:
    • A6PVF2
    • Q0P6A5
    • Q3T1C5
    • Q8TC52
    • Q9BQP3
    • Q9BQP4

    Protein attributes for WFDC3 Gene

    231 amino acids
    Molecular mass:
    24687 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI02014.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI02015.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WFDC3 Gene

Proteomics data for WFDC3 Gene at MOPED

Post-translational modifications for WFDC3 Gene

  • Glycosylation at Asn107 and Asn217

Other Protein References for WFDC3 Gene

Antibody Products

No data available for DME Specific Peptides for WFDC3 Gene

Domains for WFDC3 Gene

Gene Families for WFDC3 Gene

Protein Domains for WFDC3 Gene


Suggested Antigen Peptide Sequences for WFDC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 WAP domains.
  • Contains 4 WAP domains.
genes like me logo Genes that share domains with WFDC3: view

Function for WFDC3 Gene

Gene Ontology (GO) - Molecular Function for WFDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity --
genes like me logo Genes that share ontologies with WFDC3: view

Animal Model Products

miRNA for WFDC3 Gene

miRTarBase miRNAs that target WFDC3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for WFDC3 Gene

Localization for WFDC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC3 Gene


Subcellular locations from

Jensen Localization Image for WFDC3 Gene COMPARTMENTS Subcellular localization image for WFDC3 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for WFDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC3: view

Pathways for WFDC3 Gene

SuperPathways for WFDC3 Gene

No Data Available

Interacting Proteins for WFDC3 Gene

Selected Interacting proteins: Q8IUB2-WFDC3_HUMAN for WFDC3 Gene via MINT

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for WFDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with WFDC3: view

No data available for Pathways by source for WFDC3 Gene

Transcripts for WFDC3 Gene

Unigene Clusters for WFDC3 Gene

WAP four-disulfide core domain 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - -
SP9: - - - - - - -

Relevant External Links for WFDC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC3 Gene

mRNA expression in normal human tissues for WFDC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WFDC3 Gene

This gene is overexpressed in Testis (24.6), Skin - Sun Exposed (Lower leg) (7.1), and Skin - Not Sun Exposed (Suprapubic) (4.4).

Protein differential expression in normal tissues for WFDC3 Gene

This gene is overexpressed in Synovial fluid (68.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for WFDC3 Gene

SOURCE GeneReport for Unigene cluster for WFDC3 Gene Hs.419126

mRNA Expression by UniProt/SwissProt for WFDC3 Gene

Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with WFDC3: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Expression partners for WFDC3 Gene

Orthologs for WFDC3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for WFDC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia WFDC3 35
  • 86.09 (n)
  • 79.36 (a)
WFDC3 36
  • 48 (a)
(Pan troglodytes)
Mammalia WFDC3 35
  • 99.13 (n)
  • 99.57 (a)
WFDC3 36
  • 100 (a)
(Mus musculus)
Mammalia Wfdc3 16
Wfdc3 36
  • 68 (a)
(Bos Taurus)
Mammalia WFDC3 36
  • 65 (a)
(Monodelphis domestica)
Mammalia WFDC3 36
  • 36 (a)
Species with no ortholog for WFDC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC3 Gene

Gene Tree for WFDC3 (if available)
Gene Tree for WFDC3 (if available)

Paralogs for WFDC3 Gene

(2) SIMAP similar genes for WFDC3 Gene using alignment to 4 proteins: Pseudogenes for WFDC3 Gene

genes like me logo Genes that share paralogs with WFDC3: view

No data available for Paralogs for WFDC3 Gene

Variants for WFDC3 Gene

Sequence variations from dbSNP and Humsavar for WFDC3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs397244 -- 45,776,660(+) TATAT(A/G)TGTGT intron-variant
rs411945 -- 45,789,832(+) GATGA(C/G)TTCTC intron-variant
rs567348 -- 45,782,294(+) CCCAT(C/T)AATTC intron-variant
rs1516579 -- 45,778,505(+) GCAAC(A/T)AGGGG intron-variant
rs2056162 -- 45,776,470(+) GCATG(A/G)TGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC3 Gene

Variant ID Type Subtype PubMed ID
nsv833990 CNV Loss 17160897
esv2722452 CNV Deletion 23290073

Relevant External Links for WFDC3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC3 Gene

Disorders for WFDC3 Gene

No disorders were found for WFDC3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for WFDC3 Gene

Publications for WFDC3 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3 4
  2. The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. (PMID: 10680116) Ranganathan S. … Nicholas K.R. (J. Mol. Graph. Model. 1999) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PMID: 15950183) Clauss A. … Lundwall A. (Biochem. Biophys. Res. Commun. 2005) 3

Products for WFDC3 Gene

Sources for WFDC3 Gene

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