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Aliases for WFDC3 Gene

Aliases for WFDC3 Gene

  • WAP Four-Disulfide Core Domain 3 2 3 5
  • Putative Protease Inhibitor WAP14 3 4
  • WAP14 3 4
  • WAP Four-Disulfide Core Domain Protein 3 3
  • Protease Inhibitor WAP14 3
  • Whey Acidic Protein 14 3
  • DJ447F3.3 3

External Ids for WFDC3 Gene

Previous GeneCards Identifiers for WFDC3 Gene

  • GC20M044131
  • GC20M045041
  • GC20M045088
  • GC20M043836
  • GC20M044377
  • GC20M041144

Summaries for WFDC3 Gene

Entrez Gene Summary for WFDC3 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC3 Gene

WFDC3 (WAP Four-Disulfide Core Domain 3) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC3 Gene

Genomics for WFDC3 Gene

Regulatory Elements for WFDC3 Gene

Enhancers for WFDC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F045777 1.3 FANTOM5 Ensembl ENCODE 70.7 +11.2 11240 5.6 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS DEK WFDC3 NCOA5 TP53RK CD40 PCIF1 ENSG00000271984 ZNF335 DNTTIP1 WFDC13 RNU6ATAC38P
GH20F045783 1.2 Ensembl ENCODE 70.2 +7.7 7653 1.4 PAF1 GABPB1 ZMYM3 ZIC2 WFDC3 WFDC13 RNU6ATAC38P
GH20F045791 0.6 ENCODE 56.6 -0.4 -368 2.0 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF207 WFDC3 SLC2A10 NEURL2 CD40 DNTTIP1 UBE2C
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WFDC3 on UCSC Golden Path with GeneCards custom track

Promoters for WFDC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009752 -368 1801 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF207

Genomic Location for WFDC3 Gene

45,747,944 bp from pter
45,791,932 bp from pter
43,989 bases
Minus strand

Genomic View for WFDC3 Gene

Genes around WFDC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC3 Gene

Proteins for WFDC3 Gene

  • Protein details for WFDC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 3
    Protein Accession:
    Secondary Accessions:
    • A6PVF2
    • Q0P6A5
    • Q3T1C5
    • Q8TC52
    • Q9BQP3
    • Q9BQP4

    Protein attributes for WFDC3 Gene

    231 amino acids
    Molecular mass:
    24687 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI02014.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI02015.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WFDC3 Gene

Post-translational modifications for WFDC3 Gene

  • Glycosylation at Asn 107 and Asn 217

Other Protein References for WFDC3 Gene

No data available for DME Specific Peptides for WFDC3 Gene

Domains & Families for WFDC3 Gene

Gene Families for WFDC3 Gene

Protein Domains for WFDC3 Gene


Suggested Antigen Peptide Sequences for WFDC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 WAP domains.
  • Contains 4 WAP domains.
genes like me logo Genes that share domains with WFDC3: view

Function for WFDC3 Gene

Gene Ontology (GO) - Molecular Function for WFDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFDC3: view
genes like me logo Genes that share phenotypes with WFDC3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WFDC3

miRNA for WFDC3 Gene

miRTarBase miRNAs that target WFDC3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WFDC3 Gene

Localization for WFDC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC3 Gene


Subcellular locations from

Jensen Localization Image for WFDC3 Gene COMPARTMENTS Subcellular localization image for WFDC3 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for WFDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC3: view

Pathways & Interactions for WFDC3 Gene

SuperPathways for WFDC3 Gene

No Data Available

Interacting Proteins for WFDC3 Gene

Selected Interacting proteins: Q8IUB2-WFDC3_HUMAN for WFDC3 Gene via IID

Gene Ontology (GO) - Biological Process for WFDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with WFDC3: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC3 Gene

Transcripts for WFDC3 Gene

Unigene Clusters for WFDC3 Gene

WAP four-disulfide core domain 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - -
SP9: - - - - - - -

Relevant External Links for WFDC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WFDC3 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC3 Gene

This gene is overexpressed in Testis (x24.6), Skin - Sun Exposed (Lower leg) (x7.1), and Skin - Not Sun Exposed (Suprapubic) (x4.4).

Protein differential expression in normal tissues from HIPED for WFDC3 Gene

This gene is overexpressed in Synovial fluid (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WFDC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of WFDC3 Gene:


SOURCE GeneReport for Unigene cluster for WFDC3 Gene:


mRNA Expression by UniProt/SwissProt for WFDC3 Gene:

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with WFDC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for WFDC3 Gene

Orthologs for WFDC3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for WFDC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WFDC3 34 35
  • 99.13 (n)
(Canis familiaris)
Mammalia WFDC3 34 35
  • 86.09 (n)
(Mus musculus)
Mammalia Wfdc3 35
  • 68 (a)
(Bos Taurus)
Mammalia WFDC3 35
  • 65 (a)
(Monodelphis domestica)
Mammalia WFDC3 35
  • 36 (a)
Species where no ortholog for WFDC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC3 Gene

Gene Tree for WFDC3 (if available)
Gene Tree for WFDC3 (if available)

Paralogs for WFDC3 Gene

(2) SIMAP similar genes for WFDC3 Gene using alignment to 4 proteins: Pseudogenes for WFDC3 Gene

genes like me logo Genes that share paralogs with WFDC3: view

No data available for Paralogs for WFDC3 Gene

Variants for WFDC3 Gene

Sequence variations from dbSNP and Humsavar for WFDC3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10470050 -- 45,750,543(+) aTAGA(G/T)agcca intron-variant
rs10523104 -- 45,783,075(+) ACTAT(-/AT)GAGCA intron-variant
rs10535060 -- 45,765,261(+) ACTTT(-/A)AAAAA intron-variant
rs10562211 -- 45,783,072(+) CACAC(-/TA)TATGA intron-variant
rs10630278 -- 45,781,262(+) CATAG(-/AC)GACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC3 Gene

Variant ID Type Subtype PubMed ID
esv2722452 CNV deletion 23290073
nsv586131 CNV loss 21841781
nsv586132 CNV loss 21841781
nsv833990 CNV loss 17160897

Variation tolerance for WFDC3 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WFDC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC3 Gene

Disorders for WFDC3 Gene

Relevant External Links for WFDC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WFDC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC3 Gene

Publications for WFDC3 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. (PMID: 10680116) Ranganathan S. … Nicholas K.R. (J. Mol. Graph. Model. 1999) 2 3 64
  5. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z. … Hurle B. (Mol. Biol. Evol. 2013) 3 64

Products for WFDC3 Gene

Sources for WFDC3 Gene

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