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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WFDC2 Gene

protein-coding   GIFtS: 50
GCID: GC20P044098

WAP four-disulfide core domain 2
 Explore 11 diseases affiliated with
WFDC2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WFDC2    

Aliases
for WFDC2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
WAP Four-Disulfide Core Domain 21 2     Major Epididymis-Specific Protein E42 3
HE41 2 3     Putative Protease Inhibitor WAP52 3
WAP51 2 3     Epididymal Protein 42
EDDM41 2     Epididymis-Specific, Whey-Acidic Protein Type, Four-Disulfide Core2
DJ461P17.61     WAP Domain Containing Protein HE4-V42
Epididymal Secretory Protein E42 3     WAP Four-Disulfide Core Domain Protein 22

External Ids:    HGNC: 159391   Entrez Gene: 104062   Ensembl: ENSG000001014437   UniProtKB: Q145083   

Export aliases for WFDC2 gene to outside databases

Previous GC identifers: GC20P043826 GC20P044736 GC20P044783 GC20P043532 GC20P040839


Summaries
for WFDC2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WFDC2:
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif,
contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease
inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be
expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm
maturation. (provided by RefSeq, Jul 2008)

Gene Wiki entry for WFDC2


Genomic Views
for WFDC2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WFDC2 gene promoter:
         STAT1   Sp1   Pax-6   Pax-2   STAT1beta   Nkx2-5   IRF-1   Pax-2a   STAT1alpha   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WFDC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for WFDC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

WFDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WFDC2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P044098:  view genomic region     (about GC identifiers)

Start:
 44,098,346 bp from pter      End:
 44,110,172 bp from pter
Size:
 11,827 bases      Orientation:
 plus strand

Proteins
for WFDC2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WFDC2_HUMAN, Q14508 (See protein sequence)
Recommended Name: WAP four-disulfide core domain protein 2 precursor  
Size: 124 amino acids; 12993 Da
Subcellular location: Secreted
Secondary accessions: A2A2A5 A2A2A6 A6PVD5 Q6IB27 Q8WXV9 Q8WXW0 Q8WXW1 Q8WXW2 Q96KJ1
Alternative splicing: 5 isoforms:  Q14508-1   Q14508-2   Q14508-3   Q14508-4   Q14508-5   

Explore the universe of human proteins at neXtProt for WFDC2: NX_Q14508

WFDC2 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_006094.3  
ENSEMBL proteins: 
 ENSP00000361761   ENSP00000217425   ENSP00000404760   ENSP00000340215   ENSP00000342890  

Human Recombinant Protein Products: 
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Novus Biologicals WFDC2 Protein
Novus Biologicals WFDC2 Lysate
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Uscn Proteins for WFDC2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space TAS1686187


WFDC2 for ontologies           About GeneDecksing



WFDC2 Antibody Products: 
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ThermoFisher Antibodies for WFDC2

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Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for WFDC2

Protein Domains /
Families
for WFDC2 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
WFDC2 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR008197 Whey_acidic_protein_4-diS_core
 IPR015874 4-disulphide_core

Graphical View of Domain Structure for InterPro Entry Q14508

ProtoNet protein and cluster: Q14508

UniProtKB/Swiss-Prot: WFDC2_HUMAN, Q14508
Similarity: Contains 2 WAP domains


Function
for WFDC2 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
Products:    		 OriGene 3'-UTR Clone: WFDC2
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WFDC2
1 QIAGEN miScript miRNA Assays for microRNA that regulate WFDC2:
hsa-miR-3652
SwitchGear 3'UTR luciferase reporter plasmid: WFDC2 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WFDC2 (see all 7)
OriGene shRNA RFP: WFDC2
OriGene siRNA: WFDC2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WFDC2

Gene Editing
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Clone
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GenScript: all cDNA clones in your preferred vector: WFDC2 (NM_006103)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for WFDC2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC2 

Cell Line
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Search LifeMap BioReagents cell lines for WFDC2

In Situ Assay
Products:   
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for WFDC2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004866endopeptidase inhibitor activity TAS1686187
GO:0004867serine-type endopeptidase inhibitor activity IEA--
GO:0030414peptidase inhibitor activity ----


WFDC2 for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for WFDC2:
 Proliferating cells 


Pathways & Interactions
for WFDC2 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFDC2

1 Interacting protein for WFDC2 (Q145082, 3) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PTNP212462, 3MINT-64174 I2D: score=5 
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis TAS1686187
GO:0007283spermatogenesis TAS1686187
GO:0010951negative regulation of endopeptidase activity TAS1686187


WFDC2 for ontologies           About GeneDecksing



Drugs & Compounds
for WFDC2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

WFDC2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WFDC2
2 Novoseek chemical compound relationships for WFDC2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
oligonucleotide 26.4 1 16607372 (1)
testosterone 6.76 1 11574662 (1)

Search CenterWatch for drugs/clinical trials and news about WFDC2 

Transcripts
for WFDC2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for WFDC2 gene (5 alternative transcripts): 
NM_006103.3  NM_080733.1  NM_080734.1  NM_080735.1  NM_080736.1  

Unigene Cluster for WFDC2:

WAP four-disulfide core domain 2
Hs.2719  [show with all ESTs]
Unigene Representative Sequence: BM921431
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000372676(uc002xoo.3 uc002xop.3) ENST00000217425 ENST00000447118(uc002xoq.3)
ENST00000339946 ENST00000462062 ENST00000342873(uc002xor.3) ENST00000488143


miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WFDC2
1 QIAGEN miScript miRNA Assays for microRNA that regulate WFDC2:
hsa-miR-3652
SwitchGear 3'UTR luciferase reporter plasmid: WFDC2 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WFDC2 (see all 7)
OriGene shRNA RFP: WFDC2
OriGene siRNA: WFDC2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WFDC2
Clone
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GenScript: all cDNA clones in your preferred vector: WFDC2 (NM_006103)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for WFDC2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC2 
Primer
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Browse OriGene validated miRNA SYBR primer pairs
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC2

Additional cDNA sequence: 

AF330260.1 AF330261.1 AF330262.1 AK225528.1 AK290288.1 AK311966.1 AY212888.1 BC039816.1 
BC046106.1 CR456977.1 X63187.1 

7 DOTS entries:

DT.455898  DT.100817289  DT.92425100  DT.95072592  DT.100817290  DT.100672779  DT.120798237 

24/174 AceView cDNA sequences (see all 174):

AI298658 NM_080736 CK301175 AA335459 W67669 AA290981 AA385556 BM990005 
AW170346 BE898899 AA284324 AF330262 AI800229 AA025750 AW054677 AA010660 
BX096167 BM969057 AA403038 AA385354 BU684449 AA411533 AA287213 BM679249 

GeneLoc Exon Structure


Expression
for WFDC2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WFDC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGCTTGTC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

WFDC2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
5 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
KidneyLoop of HenleLoop of Henle CellsKidney
TestisSeminiferous TubulesSertoli cellsTestis
KidneyEpithelial TubuleKidney
KidneyLoop of HenleKidney
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

See WFDC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WFDC2

SOURCE GeneReport for Unigene cluster: Hs.2719

UniProtKB/Swiss-Prot: WFDC2_HUMAN, Q14508
Tissue specificity: Expressed in a number of normal tissues, including male reproductive system, regions of the
respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast,
lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis

    SABiosciences Custom PCR Arrays for WFDC2
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC2
In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for WFDC2

Orthologs
for WFDC2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for WFDC2 gene from 2/11 species (see all 11)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves LOC1008592721 WAP four-disulfide core domain protein 2-like 61.65(n)
53.98(a)		   100859272  XM_003642469.1  XP_003642517.1 
honey bee
(Apis mellifera)		 Insecta --
 --
 24(a)
 1 → many
 Group5.25(83189-83923)


ENSEMBL Gene Tree for WFDC2 (if available)
TreeFam Gene Tree for WFDC2 (if available) 

Paralogs
for WFDC2 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for WFDC2 gene
WFDC32  WFDC52  SLPI2  
3 SIMAP similar genes for WFDC2 using alignment to 2 protein entries:     WFDC2_HUMAN (see all proteins):
WFDC12    KAL1    WFDC13

WFDC2 for paralogs           About GeneDecksing



Genomic Variants
for WFDC2 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/282 NCBI SNPs in WFDC2 are shown (see all 282)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 20 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs790268691,2
F,--44096480(+) ACCTAG/ACACGG 1 -- us2k11Minor allele frequency- A:0.06EA 120
rs1382765891,2
--44096483(+) TAGCAC/TGGAAC 1 -- us2k10--------
rs1429582671,2
--44096526(+) TTGACG/TGATGA 1 -- us2k10--------
rs61041731,2
C,F,--44096559(+) CCTGGC/TCCTGC 1 -- us2k17Minor allele frequency- T:0.20NA WA CSA EA 365
rs1911298521,2
--44096560(+) CTGGCC/TCTGCC 1 -- us2k10--------
rs1168744541,2
--44096581(+) AGTCTG/ATATTC 1 -- us2k11Minor allele frequency- A:0.01NA 120
rs1461366651,2
--44096700(+) CAGCAA/GTGCCT 1 -- us2k10--------
rs1388867221,2
--44096738(+) GTCCAC/TGGGCT 1 -- us2k10--------
rs22395331,2
C,F,A,H,--44096817(+) TGTGTC/TCCCAC 1 -- us2k117Minor allele frequency- T:0.46EA NS NA WA CSA 2589
rs1494393301,2
--44097021(+) CCCAGG/TGCCCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for WFDC2 (44098346 - 44110172 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for WFDC2: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC2
DNA2.0 Custom Variant and Variant Library Synthesis for WFDC2

Disorders / Diseases
for WFDC2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
WFDC2 for disorders           About GeneDecksing

11 diseases for WFDC2:    About MalaCards
ovarian cancer    epididymitis    epithelial ovarian cancer    ovarian carcinoma
noma    endometrial cancer    lung adenocarcinoma    adenocarcinoma
endometriosis    carcinoma    breast cancer

1 disease from the University of Copenhagen DISEASES database for WFDC2:
Ovarian cancer

6 Novoseek disease relationships for WFDC2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian carcinoma 57.4 9 12839961 (3), 15781627 (2), 19053170 (1), 20126474 (1)
ovarian cancer 53.6 11 19337252 (3), 20478777 (3), 11965550 (2), 15781627 (1)
carcinoma 16.6 4 15781627 (2), 16607372 (1)
adenocarcinoma 4.71 4 16600032 (2), 16607372 (1)
tumors 0 7 15161682 (2), 15781627 (1), 16607372 (1), 17982616 (1)
cancer 0 2 16455481 (1), 19337252 (1)


Export disorders for WFDC2 gene to outside databases

Publications
for WFDC2 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for WFDC2 gene, integrated from 9 sources (see all 68):
(articles sorted by number of sources associating them with WFDC2)		    Utopia: connect your pdf to the dynamic
world of online information

  1. A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. (PubMed id 1686187)1, 2, 3, 9 Kirchhoff C.... Krull N. (1991)
  2. Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. (PubMed id 15781627)1, 2, 9 Drapkin R....Hecht J.L. (2005)
  3. The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. (PubMed id 12839961)1, 2, 9 Hellstrom I.... Hellstrom K.E. (2003)
  4. The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms. (PubMed id 11965550)1, 2, 9 Bingle L.... Bingle C.D. (2002)
  5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  8. Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas. (PubMed id 10570965)1, 3 Schummer M....Hood L. (1999)
  9. WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung. (PubMed id 16600032)1, 9 Bingle L....Bingle C.D. (2006)
  10. Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts. (PubMed id 19337252)1, 9 Huhtinen K....Perheentupa A. (2009)

External Searches for WFDC2 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
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Genome Databases showing WFDC2 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10406 HGNC: 15939 AceView: WFDC2 Ensembl:ENSG00000101443 euGenes: HUgn10406
ECgene: WFDC2 H-InvDB: WFDC2

Other Databases showing WFDC2 gene

(According to HUGE)
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   --

Specialized Databases showing WFDC2 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for WFDC2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WFDC2 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for WFDC2 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for WFDC2 gene:
Search GeneIP for patents involving WFDC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for WFDC2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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