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Aliases for WFDC2 Gene

Aliases for WFDC2 Gene

  • WAP Four-Disulfide Core Domain 2 2 3
  • Major Epididymis-Specific Protein E4 3 4
  • Putative Protease Inhibitor WAP5 3 4
  • Epididymal Secretory Protein E4 3 4
  • Epididymal Protein 4 2 3
  • WAP5 3 4
  • HE4 3 4
  • Epididymis-Specific, Whey-Acidic Protein Type, Four-Disulfide Core 3
  • WAP Four-Disulfide Core Domain Protein 2 3
  • WAP Domain Containing Protein HE4-V4 3
  • DJ461P17.6 3
  • EDDM4 3

External Ids for WFDC2 Gene

Previous GeneCards Identifiers for WFDC2 Gene

  • GC20P043826
  • GC20P044736
  • GC20P044783
  • GC20P043532
  • GC20P044098
  • GC20P040839

Summaries for WFDC2 Gene

Entrez Gene Summary for WFDC2 Gene

  • This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC2 Gene

WFDC2 (WAP Four-Disulfide Core Domain 2) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for WFDC2 Gene

  • Broad range protease inhibitor.

Gene Wiki entry for WFDC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC2 Gene

Genomics for WFDC2 Gene

Regulatory Elements for WFDC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WFDC2 Gene

45,469,706 bp from pter
45,481,532 bp from pter
11,827 bases
Plus strand

Genomic View for WFDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WFDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC2 Gene

Proteins for WFDC2 Gene

  • Protein details for WFDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 2
    Protein Accession:
    Secondary Accessions:
    • A2A2A5
    • A2A2A6
    • A6PVD5
    • Q6IB27
    • Q8WXV9
    • Q8WXW0
    • Q8WXW1
    • Q8WXW2
    • Q96KJ1

    Protein attributes for WFDC2 Gene

    124 amino acids
    Molecular mass:
    12993 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked.

    Alternative splice isoforms for WFDC2 Gene


neXtProt entry for WFDC2 Gene

Proteomics data for WFDC2 Gene at MOPED

Post-translational modifications for WFDC2 Gene

Other Protein References for WFDC2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for WFDC2

No data available for DME Specific Peptides for WFDC2 Gene

Domains for WFDC2 Gene

Gene Families for WFDC2 Gene

  • WFDC :WAP four-disulfide core domain containing

Protein Domains for WFDC2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q14508
  • Contains 2 WAP domains.
genes like me logo Genes that share domains with WFDC2: view

Function for WFDC2 Gene

Molecular function for WFDC2 Gene

UniProtKB/Swiss-Prot Function: Broad range protease inhibitor.

Gene Ontology (GO) - Molecular Function for WFDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 1686187
GO:0004867 serine-type endopeptidase inhibitor activity IDA 23139753
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0019828 aspartic-type endopeptidase inhibitor activity IDA 23139753
GO:0030414 peptidase inhibitor activity --
genes like me logo Genes that share ontologies with WFDC2: view

Phenotypes for WFDC2 Gene

GenomeRNAi human phenotypes for WFDC2:
genes like me logo Genes that share phenotypes with WFDC2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WFDC2 Gene

Localization for WFDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC2 Gene


Subcellular locations from

Jensen Localization Image for WFDC2 Gene COMPARTMENTS Subcellular localization image for WFDC2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for WFDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space TAS 1686187
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with WFDC2: view

Pathways for WFDC2 Gene

SuperPathways for WFDC2 Gene

No Data Available

Interacting Proteins for WFDC2 Gene

Selected Interacting proteins: Q14508-WFDC2_HUMAN for WFDC2 Gene via MINT I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for WFDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 1686187
GO:0007283 spermatogenesis TAS 1686187
GO:0010466 negative regulation of peptidase activity --
GO:0010951 negative regulation of endopeptidase activity TAS 1686187
genes like me logo Genes that share ontologies with WFDC2: view

No data available for Pathways by source for WFDC2 Gene

Compounds for WFDC2 Gene

(2) Novoseek inferred chemical compound relationships for WFDC2 Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 26.4 1
testosterone 6.76 1
genes like me logo Genes that share compounds with WFDC2: view

Transcripts for WFDC2 Gene

Unigene Clusters for WFDC2 Gene

WAP four-disulfide core domain 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC2 Gene

No ASD Table

Relevant External Links for WFDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC2 Gene

mRNA expression in normal human tissues for WFDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WFDC2 Gene

This gene is overexpressed in Cervix - Endocervix (11.2), Minor Salivary Gland (10.2), and Kidney - Cortex (10.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for WFDC2 Gene

SOURCE GeneReport for Unigene cluster for WFDC2 Gene Hs.2719

mRNA Expression by UniProt/SwissProt for WFDC2 Gene

Tissue specificity: Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.
genes like me logo Genes that share expressions with WFDC2: view

In Situ Assay Products

Orthologs for WFDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WFDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WFDC2 35
  • 99.73 (n)
  • 100 (a)
WFDC2 36
  • 100 (a)
(Bos Taurus)
Mammalia WFDC2 35
  • 73.98 (n)
  • 68.29 (a)
WFDC2 36
  • 52 (a)
(Canis familiaris)
Mammalia WFDC2 35
  • 83.06 (n)
  • 78.23 (a)
WFDC2 36
  • 58 (a)
(Mus musculus)
Mammalia Wfdc2 35
  • 74.04 (n)
  • 63.93 (a)
Wfdc2 16
Wfdc2 36
  • 45 (a)
(Monodelphis domestica)
Mammalia WFDC2 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia WFDC2 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Wfdc2 35
  • 74.32 (n)
  • 61.48 (a)
(Gallus gallus)
Aves WFDC2 36
  • 6 (a)
Species with no ortholog for WFDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC2 Gene

Gene Tree for WFDC2 (if available)
Gene Tree for WFDC2 (if available)

Paralogs for WFDC2 Gene

Selected SIMAP similar genes for WFDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WFDC2: view

No data available for Paralogs for WFDC2 Gene

Variants for WFDC2 Gene

Sequence variations from dbSNP and Humsavar for WFDC2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs9880 -- 45,480,062(+) CTGTG(A/G)GAAGG missense, reference
rs960352 -- 45,481,012(-) CTTTA(A/G)GTTAA intron-variant
rs1997745 -- 45,470,697(+) GGCCC(A/C)GGGGT intron-variant
rs2072956 -- 45,469,654(-) TTTGC(C/G)GGCAC upstream-variant-2KB
rs2092368 -- 45,476,152(+) tttaa(C/T)tgggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC2 Gene

Variant ID Type Subtype PubMed ID
nsv912892 CNV Loss 21882294

Relevant External Links for WFDC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC2 Gene

Disorders for WFDC2 Gene

(1) University of Copenhagen DISEASES for WFDC2 Gene

(6) Novoseek inferred disease relationships for WFDC2 Gene

Disease -log(P) Hits PubMed IDs
ovarian carcinoma 57.4 7
ovarian cancer 53.6 9
carcinoma 16.6 3
adenocarcinoma 4.71 3
tumors 0 5

Relevant External Links for WFDC2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with WFDC2: view

No data available for UniProtKB/Swiss-Prot for WFDC2 Gene

Publications for WFDC2 Gene

  1. A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. (PMID: 1686187) Kirchhoff C. … Krull N. (Biol. Reprod. 1991) 2 3 4 23
  2. Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. (PMID: 15781627) Drapkin R. … Hecht J.L. (Cancer Res. 2005) 3 4 23
  3. The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. (PMID: 12839961) Hellstrom I. … Hellstrom K.E. (Cancer Res. 2003) 3 4 23
  4. The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms. (PMID: 11965550) Bingle L. … Bingle C.D. (Oncogene 2002) 3 4 23
  5. Molecular characterization of epididymal proteins. (PMID: 9685187) Kirchhoff C. (Rev. Reprod. 1998) 3 23

Products for WFDC2 Gene

  • Addgene plasmids for WFDC2

Sources for WFDC2 Gene

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