Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WFDC2 Gene

Aliases for WFDC2 Gene

  • WAP Four-Disulfide Core Domain 2 2 3 5
  • Major Epididymis-Specific Protein E4 3 4
  • Putative Protease Inhibitor WAP5 3 4
  • Epididymal Secretory Protein E4 3 4
  • Epididymal Protein 4 2 3
  • WAP5 3 4
  • HE4 3 4
  • Epididymis-Specific, Whey-Acidic Protein Type, Four-Disulfide Core 3
  • WAP Domain Containing Protein HE4-V4 3
  • DJ461P17.6 3
  • EDDM4 3

External Ids for WFDC2 Gene

Previous GeneCards Identifiers for WFDC2 Gene

  • GC20P043826
  • GC20P044736
  • GC20P044783
  • GC20P043532
  • GC20P044098
  • GC20P040839

Summaries for WFDC2 Gene

Entrez Gene Summary for WFDC2 Gene

  • This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC2 Gene

WFDC2 (WAP Four-Disulfide Core Domain 2) is a Protein Coding gene. Diseases associated with WFDC2 include Ovarian Cancer. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for WFDC2 Gene

  • Broad range protease inhibitor.

Gene Wiki entry for WFDC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC2 Gene

Genomics for WFDC2 Gene

Regulatory Elements for WFDC2 Gene

Enhancers for WFDC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WFDC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for WFDC2 Gene

45,448,648 bp from pter
45,481,532 bp from pter
32,885 bases
Plus strand

Genomic View for WFDC2 Gene

Genes around WFDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC2 Gene

Proteins for WFDC2 Gene

  • Protein details for WFDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 2
    Protein Accession:
    Secondary Accessions:
    • A2A2A5
    • A2A2A6
    • A6PVD5
    • Q6IB27
    • Q8WXV9
    • Q8WXW0
    • Q8WXW1
    • Q8WXW2
    • Q96KJ1

    Protein attributes for WFDC2 Gene

    124 amino acids
    Molecular mass:
    12993 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked.

    Alternative splice isoforms for WFDC2 Gene


neXtProt entry for WFDC2 Gene

Proteomics data for WFDC2 Gene at MOPED

Post-translational modifications for WFDC2 Gene

Other Protein References for WFDC2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for WFDC2

No data available for DME Specific Peptides for WFDC2 Gene

Domains & Families for WFDC2 Gene

Gene Families for WFDC2 Gene

Protein Domains for WFDC2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 2 WAP domains.
  • Contains 2 WAP domains.
genes like me logo Genes that share domains with WFDC2: view

Function for WFDC2 Gene

Molecular function for WFDC2 Gene

UniProtKB/Swiss-Prot Function:
Broad range protease inhibitor.

Gene Ontology (GO) - Molecular Function for WFDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFDC2: view

Phenotypes for WFDC2 Gene

GenomeRNAi human phenotypes for WFDC2:
genes like me logo Genes that share phenotypes with WFDC2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WFDC2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC2 Gene

Localization for WFDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC2 Gene


Subcellular locations from

Jensen Localization Image for WFDC2 Gene COMPARTMENTS Subcellular localization image for WFDC2 gene
Compartment Confidence
extracellular 5
cytosol 2

Gene Ontology (GO) - Cellular Components for WFDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC2: view

Pathways & Interactions for WFDC2 Gene

SuperPathways for WFDC2 Gene

No Data Available

Interacting Proteins for WFDC2 Gene

Selected Interacting proteins: Q14508-WFDC2_HUMAN for WFDC2 Gene via MINT I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for WFDC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for WFDC2 Gene

Drugs & Compounds for WFDC2 Gene

(1) Drugs for WFDC2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for WFDC2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WFDC2: view

Transcripts for WFDC2 Gene

Unigene Clusters for WFDC2 Gene

WAP four-disulfide core domain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC2 Gene

No ASD Table

Relevant External Links for WFDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC2 Gene

mRNA expression in normal human tissues for WFDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WFDC2 Gene

This gene is overexpressed in Cervix - Endocervix (x11.2), Minor Salivary Gland (x10.2), and Kidney - Cortex (x10.1).

Protein differential expression in normal tissues from HIPED for WFDC2 Gene

This gene is overexpressed in Urine (35.8), Cervix (20.6), and Saliva (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WFDC2 Gene

SOURCE GeneReport for Unigene cluster for WFDC2 Gene Hs.2719

mRNA Expression by UniProt/SwissProt for WFDC2 Gene

Tissue specificity: Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.
genes like me logo Genes that share expression patterns with WFDC2: view

Protein tissue co-expression partners for WFDC2 Gene

Primer Products

Orthologs for WFDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WFDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WFDC2 35
  • 73.98 (n)
  • 68.29 (a)
WFDC2 36
  • 52 (a)
(Canis familiaris)
Mammalia WFDC2 35
  • 83.06 (n)
  • 78.23 (a)
WFDC2 36
  • 58 (a)
(Mus musculus)
Mammalia Wfdc2 35
  • 74.04 (n)
  • 63.93 (a)
Wfdc2 16
Wfdc2 36
  • 45 (a)
(Pan troglodytes)
Mammalia WFDC2 35
  • 99.73 (n)
  • 100 (a)
WFDC2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wfdc2 35
  • 74.32 (n)
  • 61.48 (a)
(Monodelphis domestica)
Mammalia WFDC2 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia WFDC2 36
  • 60 (a)
(Gallus gallus)
Aves WFDC2 36
  • 6 (a)
Species with no ortholog for WFDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC2 Gene

Gene Tree for WFDC2 (if available)
Gene Tree for WFDC2 (if available)

Paralogs for WFDC2 Gene

(1) SIMAP similar genes for WFDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WFDC2: view

No data available for Paralogs for WFDC2 Gene

Variants for WFDC2 Gene

Sequence variations from dbSNP and Humsavar for WFDC2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs9880 -- 45,480,062(+) CTGTG(A/G)GAAGG reference, missense
rs973446 -- 45,465,735(-) TTTCT(C/G)TTGCT intron-variant
rs973447 -- 45,465,504(-) GGCTC(A/G)GGTCC intron-variant
rs1016496 -- 45,456,820(-) GAACC(C/T)GAGGG intron-variant
rs1028365 -- 45,456,901(-) TTGGC(A/T)GCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC2 Gene

Variant ID Type Subtype PubMed ID
nsv912892 CNV Loss 21882294

Variation tolerance for WFDC2 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WFDC2 Gene

Disorders for WFDC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WFDC2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
- elite association - COSMIC cancer census association via MalaCards
Search WFDC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WFDC2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WFDC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WFDC2 Gene

Publications for WFDC2 Gene

  1. A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. (PMID: 1686187) Kirchhoff C. … Krull N. (Biol. Reprod. 1991) 2 3 4 23 67
  2. Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts. (PMID: 19337252) Huhtinen K. … Perheentupa A. (Br. J. Cancer 2009) 3 23
  3. HE4 as a biomarker for ovarian and endometrial cancer management. (PMID: 19732003) Li J. … Jiang S.W. (Expert Rev. Mol. Diagn. 2009) 3 23
  4. WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung. (PMID: 16600032) Bingle L. … Bingle C.D. (Respir. Res. 2006) 3 23
  5. Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. (PMID: 15781627) Drapkin R. … Hecht J.L. (Cancer Res. 2005) 3 23

Products for WFDC2 Gene

Sources for WFDC2 Gene