Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WFDC13 Gene

Aliases for WFDC13 Gene

  • WAP Four-Disulfide Core Domain 13 2 3 5
  • C20orf138 3 4
  • WAP13 3 4
  • WAP Four-Disulfide Core Domain Protein 13 3
  • Chromosome 20 Open Reading Frame 138 2
  • Protease Inhibitor WAP13 3
  • Protein WFDC13 3
  • DJ601O1.3 3

External Ids for WFDC13 Gene

Previous HGNC Symbols for WFDC13 Gene

  • C20orf138

Previous GeneCards Identifiers for WFDC13 Gene

  • GC20U900002
  • GC20P044969
  • GC20P045017
  • GC20P045018
  • GC20P043764
  • GC20P044330
  • GC20P041072

Summaries for WFDC13 Gene

Entrez Gene Summary for WFDC13 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC13 Gene

WFDC13 (WAP Four-Disulfide Core Domain 13) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for WFDC13 Gene

  • Putative acid-stable proteinase inhibitor.

Additional gene information for WFDC13 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC13 Gene

Genomics for WFDC13 Gene

Regulatory Elements for WFDC13 Gene

Enhancers for WFDC13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H045770 1.5 Ensembl ENCODE dbSUPER 15.8 +69.3 69322 1 FOXA2 MLX ARID4B SLC30A9 GATA2 ZNF143 DEK MXD4 REST MIER2 WFDC3 WFDC13 SPINT5P HNRNPA1P3 DNTTIP1 EPPIN EPPIN-WFDC6 HSPD1P21 WFDC6 ENSG00000232135
GH20H045777 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.1 +78.7 78677 5 PKNOX1 ATF1 BRCA1 ATF7 FOS DEK REST MAFF SMARCA4 GLIS1 WFDC3 DNTTIP1 WFDC13 RNU6ATAC38P
GH20H045725 0.9 ENCODE 10.6 +23.2 23240 0 FOXA2 ARID4B RARA HSF1 RCOR1 CREM MIXL1 THAP11 HMG20B CEBPB PIGT HNRNPA1P3 SPINT5P WFDC10B WFDC13 SPINT4
GH20H045817 1.4 Ensembl ENCODE dbSUPER 6.3 +115.9 115906 1 HDAC1 KLF17 ZEB1 TCF12 ZNF121 GLIS2 ZNF366 SCRT2 RCOR1 ATF7 WFDC3 PLTP NCOA5 ZSWIM3 ACOT8 DNTTIP1 ZSWIM1 NEURL2 SPATA25 CTSA
GH20H045765 0.4 ENCODE 16.3 +64.4 64388 2 POLR2A WFDC3 WFDC13 DNTTIP1 HNRNPA1P3 EPPIN-WFDC6 EPPIN ENSG00000232135 HSPD1P21 WFDC6 SPINT3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WFDC13 on UCSC Golden Path with GeneCards custom track

Genomic Location for WFDC13 Gene

Chromosome:
20
Start:
45,702,016 bp from pter
End:
45,708,817 bp from pter
Size:
6,802 bases
Orientation:
Plus strand

Genomic View for WFDC13 Gene

Genes around WFDC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC13 Gene

Proteins for WFDC13 Gene

  • Protein details for WFDC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUB5-WFD13_HUMAN
    Recommended name:
    WAP four-disulfide core domain protein 13
    Protein Accession:
    Q8IUB5
    Secondary Accessions:
    • Q5TEU7
    • Q8WWK7

    Protein attributes for WFDC13 Gene

    Size:
    93 amino acids
    Molecular mass:
    10386 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WFDC13 Gene

Post-translational modifications for WFDC13 Gene

No Post-translational modifications

Other Protein References for WFDC13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC13 Gene

Domains & Families for WFDC13 Gene

Gene Families for WFDC13 Gene

Protein Domains for WFDC13 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WFDC13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WFDC13: view

No data available for UniProtKB/Swiss-Prot for WFDC13 Gene

Function for WFDC13 Gene

Molecular function for WFDC13 Gene

UniProtKB/Swiss-Prot Function:
Putative acid-stable proteinase inhibitor.

Gene Ontology (GO) - Molecular Function for WFDC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFDC13: view
genes like me logo Genes that share phenotypes with WFDC13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WFDC13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC13 Gene

Localization for WFDC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC13 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for WFDC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WFDC13 Gene

Pathways & Interactions for WFDC13 Gene

SuperPathways for WFDC13 Gene

No Data Available

Interacting Proteins for WFDC13 Gene

Selected Interacting proteins: Q8IUB5-WFD13_HUMAN for WFDC13 Gene via IID

Symbol External ID(s) Details
EIF4A1

Gene Ontology (GO) - Biological Process for WFDC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with WFDC13: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC13 Gene

Drugs & Compounds for WFDC13 Gene

No Compound Related Data Available

Transcripts for WFDC13 Gene

mRNA/cDNA for WFDC13 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WFDC13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC13 Gene

No ASD Table

Relevant External Links for WFDC13 Gene

GeneLoc Exon Structure for
WFDC13
ECgene alternative splicing isoforms for
WFDC13

Expression for WFDC13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WFDC13 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC13 Gene

This gene is overexpressed in Bladder (x12.1).

NURSA nuclear receptor signaling pathways regulating expression of WFDC13 Gene:

WFDC13

SOURCE GeneReport for Unigene cluster for WFDC13 Gene:

Hs.406733
genes like me logo Genes that share expression patterns with WFDC13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WFDC13 Gene

Orthologs for WFDC13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for WFDC13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WFDC13 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia WFDC13 33 34
  • 78.57 (n)
dog
(Canis familiaris)
Mammalia WFDC13 34
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wfdc13 34
  • 53 (a)
OneToOne
Species where no ortholog for WFDC13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC13 Gene

ENSEMBL:
Gene Tree for WFDC13 (if available)
TreeFam:
Gene Tree for WFDC13 (if available)

Paralogs for WFDC13 Gene

No data available for Paralogs for WFDC13 Gene

Variants for WFDC13 Gene

Sequence variations from dbSNP and Humsavar for WFDC13 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000818625 -- 45,703,851(+) CATTC(G/T)GAAAT intron-variant
rs1000828863 -- 45,707,563(+) ACATT(A/T)TAAAT intron-variant
rs1000932052 -- 45,707,150(+) TTTCT(A/G)TTAAA intron-variant, upstream-variant-2KB
rs1001056750 -- 45,700,836(+) CATTA(A/G)AAATG intron-variant, upstream-variant-2KB
rs1002233434 -- 45,704,563(+) TAGTC(C/T)GTTCA reference, missense, splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC13 Gene

Variant ID Type Subtype PubMed ID
dgv1247e212 CNV loss 25503493
esv2751915 CNV loss 17911159
nsv525287 CNV loss 19592680
nsv586081 CNV loss 21841781

Variation tolerance for WFDC13 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WFDC13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WFDC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC13 Gene

Disorders for WFDC13 Gene

Relevant External Links for WFDC13

Genetic Association Database (GAD)
WFDC13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WFDC13

No disorders were found for WFDC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC13 Gene

Publications for WFDC13 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A … Lundwall A (The Biochemical journal 2002) 2 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  3. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z … Hurle B (Molecular biology and evolution 2013) 3 60
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 45 60
  5. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PMID: 15950183) Clauss A … Lundwall A (Biochemical and biophysical research communications 2005) 3 60

Products for WFDC13 Gene

Sources for WFDC13 Gene

Content
Loading form....