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Aliases for WFDC13 Gene

Aliases for WFDC13 Gene

  • WAP Four-Disulfide Core Domain 13 2 3 5
  • C20orf138 3 4
  • WAP13 3 4
  • Chromosome 20 Open Reading Frame 138 2
  • Protease Inhibitor WAP13 3
  • Protein WFDC13 3
  • DJ601O1.3 3

External Ids for WFDC13 Gene

Previous HGNC Symbols for WFDC13 Gene

  • C20orf138

Previous GeneCards Identifiers for WFDC13 Gene

  • GC20U900002
  • GC20P044969
  • GC20P045017
  • GC20P045018
  • GC20P043764
  • GC20P044330
  • GC20P041072

Summaries for WFDC13 Gene

Entrez Gene Summary for WFDC13 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC13 Gene

WFDC13 (WAP Four-Disulfide Core Domain 13) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for WFDC13 Gene

  • Putative acid-stable proteinase inhibitor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC13 Gene

Genomics for WFDC13 Gene

Regulatory Elements for WFDC13 Gene

Enhancers for WFDC13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WFDC13 on UCSC Golden Path with GeneCards custom track

Genomic Location for WFDC13 Gene

45,702,016 bp from pter
45,708,817 bp from pter
6,802 bases
Plus strand

Genomic View for WFDC13 Gene

Genes around WFDC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC13 Gene

Proteins for WFDC13 Gene

  • Protein details for WFDC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 13
    Protein Accession:
    Secondary Accessions:
    • Q5TEU7
    • Q8WWK7

    Protein attributes for WFDC13 Gene

    93 amino acids
    Molecular mass:
    10386 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WFDC13 Gene

Proteomics data for WFDC13 Gene at MOPED

Post-translational modifications for WFDC13 Gene

No Post-translational modifications

Other Protein References for WFDC13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC13 Gene

Domains & Families for WFDC13 Gene

Gene Families for WFDC13 Gene

Protein Domains for WFDC13 Gene


Suggested Antigen Peptide Sequences for WFDC13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 WAP domain.
  • Contains 1 WAP domain.
genes like me logo Genes that share domains with WFDC13: view

Function for WFDC13 Gene

Molecular function for WFDC13 Gene

UniProtKB/Swiss-Prot Function:
Putative acid-stable proteinase inhibitor.
genes like me logo Genes that share phenotypes with WFDC13: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC13 Gene

Localization for WFDC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC13 Gene


Subcellular locations from

Jensen Localization Image for WFDC13 Gene COMPARTMENTS Subcellular localization image for WFDC13 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for WFDC13 Gene

Pathways & Interactions for WFDC13 Gene

SuperPathways for WFDC13 Gene

No Data Available

Interacting Proteins for WFDC13 Gene

Gene Ontology (GO) - Biological Process for WFDC13 Gene


No data available for Pathways by source and SIGNOR curated interactions for WFDC13 Gene

Drugs & Compounds for WFDC13 Gene

No Compound Related Data Available

Transcripts for WFDC13 Gene

mRNA/cDNA for WFDC13 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC13 Gene

No ASD Table

Relevant External Links for WFDC13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC13 Gene

mRNA expression in normal human tissues for WFDC13 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC13 Gene

This gene is overexpressed in Bladder (x12.1).

SOURCE GeneReport for Unigene cluster for WFDC13 Gene Hs.406733

genes like me logo Genes that share expression patterns with WFDC13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for WFDC13 Gene

Orthologs for WFDC13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for WFDC13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WFDC13 35
  • 78.57 (n)
  • 63.1 (a)
WFDC13 36
  • 60 (a)
(Pan troglodytes)
Mammalia WFDC13 35
  • 100 (n)
  • 100 (a)
WFDC13 36
  • 100 (a)
(Canis familiaris)
Mammalia WFDC13 36
  • 67 (a)
(Mus musculus)
Mammalia Wfdc13 36
  • 53 (a)
Species with no ortholog for WFDC13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC13 Gene

Gene Tree for WFDC13 (if available)
Gene Tree for WFDC13 (if available)

Paralogs for WFDC13 Gene

No data available for Paralogs for WFDC13 Gene

Variants for WFDC13 Gene

Sequence variations from dbSNP and Humsavar for WFDC13 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs170800 -- 45,708,217(-) GATCA(A/G)TTAGC utr-variant-3-prime
rs232286 -- 45,709,047(-) AGTGC(A/G)TACAA downstream-variant-500B
rs232287 -- 45,707,427(-) tgacc(A/G)gtgcc intron-variant
rs232288 -- 45,707,336(-) CAACT(C/T)GAACC intron-variant
rs6017653 -- 45,708,285(+) GCCAG(C/T)CTTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WFDC13 Gene

Variant ID Type Subtype PubMed ID
nsv525287 CNV Loss 19592680
esv2751915 CNV Loss 17911159

Variation tolerance for WFDC13 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WFDC13 Gene

Disorders for WFDC13 Gene

Relevant External Links for WFDC13

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WFDC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC13 Gene

Publications for WFDC13 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3 4 67
  2. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z. … Hurle B. (Mol. Biol. Evol. 2013) 3
  3. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PMID: 15950183) Clauss A. … Lundwall A. (Biochem. Biophys. Res. Commun. 2005) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3

Products for WFDC13 Gene

Sources for WFDC13 Gene