WFDC13 Gene
protein-coding GIFtS: 37
GCID: GC20P044330
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WAP four-disulfide core domain 13(Previous name: chromosome 20 open reading frame 138 )
(Previous symbol: C20orf138)
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Aliases
for WFDC13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WAP Four-Disulfide Core Domain 131 2 | | Chromosome 20 Open Reading Frame 1381 | | C20orf1381 2 3 | | Protease Inhibitor WAP132 | | WAP131 2 3 | | Protein WFDC132 | | DJ601O1.31 | | WAP Four-Disulfide Core Domain Protein 132 |
Export aliases for WFDC13 gene to outside databasesPrevious GC identifers: GC20U900002 GC20P044969 GC20P045017 GC20P045018 GC20P043764 GC20P041072 |
Summaries
for WFDC13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WFDC13:
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signaturemotif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a proteaseinhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric.This gene belongs to the telomeric cluster. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: WFD13_HUMAN, Q8IUB5Function: Putative acid-stable proteinase inhibitor (By similarity)
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Genomic Views
for WFDC13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for WFDC13
Other transcription factors
Search SABiosciences Chromatin IP Primers for WFDC13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.11WFDC13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P044330: view genomic region
(about GC identifiers)
Start:
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44,330,655 bp from pter |
End:
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44,337,456 bp from pter |
Size:
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6,802 bases |
Orientation:
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plus strand |
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Proteins
for WFDC13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WFD13_HUMAN, Q8IUB5 (See
protein sequence)Recommended Name: WAP four-disulfide core domain protein 13 precursor Size: 93 amino acids; 10386 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q5TEU7 Q8WWK7Explore the universe of human proteins at neXtProt for WFDC13: NX_Q8IUB5
WFDC13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_742002.1
ENSEMBL proteins: ENSP00000302938
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
WFDC13 for ontologies About GeneDecksing
WFDC13 Antibody Products:
Assay Products for WFDC13: |
Protein
Domains /
Families
for WFDC13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WFDC13 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IUB5ProtoNet protein and cluster: Q8IUB5 1 Blocks protein family: IPB008197 4-disulphide core signature
UniProtKB/Swiss-Prot: WFD13_HUMAN, Q8IUB5Similarity: Contains 1 WAP domain |
Function
for WFDC13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WFD13_HUMAN, Q8IUB5Function: Putative acid-stable proteinase inhibitor (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC13 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WFDC13 (NM_172005) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WFDC13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC13 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC13 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity |
IEA | -- |
WFDC13 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for WFDC13:
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Pathways & Interactions
for WFDC13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFDC13
|
Drugs & Compounds
for WFDC13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WFDC13
Search CenterWatch for drugs/clinical trials and news about WFDC13 / WFD13
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Transcripts
for WFDC13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WFDC13 gene: NM_172005.1 Unigene Clusters for WFDC13: WAP four-disulfide core domain 13 Hs.406733 , Hs.690734 Unigene Representative Sequences: AF454505, BC1044231 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000305479(uc002xpd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC13 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WFDC13 (NM_172005) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WFDC13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC13 |
Additional cDNA sequence: BC104423.1 1 DOTS entry: DT.99997517 2 AceView cDNA sequences: NM_172005 AF454505
GeneLoc Exon Structure
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Expression
for WFDC13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WFDC13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See WFDC13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WFDC13
SOURCE GeneReport for Unigene clusters: Hs.406733 Hs.690734
SABiosciences Custom PCR Arrays for WFDC13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat WFDC13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC13 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC13 |
Orthologs
for WFDC13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for WFDC13 gene from 1/3 species (see all 3) About this table
ENSEMBL Gene Tree for WFDC13 (if available)
TreeFam Gene Tree for WFDC13 (if available) |
Paralogs
for WFDC13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WFDC13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WFDC13 (44330655 - 44337456 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WFDC13
1 CNV: 9320 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for WFDC13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WFDC13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WFDC13 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WFDC13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 2, 3 Clauss A.... Lundwall A. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- The evolution of a genetic locus encoding small serine proteinase inhibitors. (PubMed id 15950183)1 Clauss A....Lundwall A. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for WFDC13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing WFDC13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WFDC13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WFDC13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WFDC13 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for WFDC13 gene:
Search GeneIP for patents involving WFDC13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WFDC13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WFDC13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WFDC13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC13 | | | OriGene Protein Over-expression Lysate for WFDC13 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WFDC13 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WFDC13 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WFDC13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC13 |
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| | | | Search Tocris compounds for WFDC13 |
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 | | | WFDC13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC13 |
|  |  |  | | | | Search ThermoFisher Antibodies for WFDC13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC13 |
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