WFDC12 Gene
protein-coding GIFtS: 46
GCID: GC20M043752
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WAP four-disulfide core domain 12(Previous name: chromosome 20 open reading frame 122 )
(Previous symbol: C20orf122)
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Aliases
for WFDC12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WAP Four-Disulfide Core Domain 121 2 | | SWAM22 5 | | WAP21 2 3 5 | | Chromosome 20 Open Reading Frame 1221 | | C20orf1221 2 3 | | Protease Inhibitor WAP22 | | DJ211D12.41 | | Single WAP Motif Protein 22 | | Putative Protease Inhibitor WAP122 3 | | WAP Four-Disulfide Core Domain Protein 122 | | Whey Acidic Protein 22 3 | | |
Export aliases for WFDC12 gene to outside databasesPrevious GC identifers: GC20M043440 GC20M044390 GC20M044437 GC20M043185 GC20M040493 |
Summaries
for WFDC12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WFDC12:
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signaturemotif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a proteaseinhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric.This gene belongs to the centromeric cluster. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: WFD12_HUMAN, Q8WWY7Function: Antibacterial protein. Putative acid-stable proteinase inhibitor
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Genomic Views
for WFDC12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WFDC12 gene promoter:
AP-1 POU2F1 POU2F1a Nkx5-1 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for WFDC12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12WFDC12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M043752: view genomic region
(about GC identifiers)
Start:
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43,752,066 bp from pter |
End:
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43,753,106 bp from pter |
Size:
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1,041 bases |
Orientation:
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minus strand |
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Proteins
for WFDC12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WFD12_HUMAN, Q8WWY7 (See
protein sequence)Recommended Name: WAP four-disulfide core domain protein 12 precursor Size: 111 amino acids; 12050 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q5H980 Q9BR31Explore the universe of human proteins at neXtProt for WFDC12: NX_Q8WWY7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WWY7
WFDC12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_543145.1
ENSEMBL proteins: ENSP00000361871
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
WFDC12 for ontologies About GeneDecksing
WFDC12 Antibody Products:
Assay Products for WFDC12: |
Protein
Domains /
Families
for WFDC12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WFDC12 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WWY7ProtoNet protein and cluster: Q8WWY7 1 Blocks protein family: IPB008197 4-disulphide core signature
UniProtKB/Swiss-Prot: WFD12_HUMAN, Q8WWY7Similarity: Contains 1 WAP domain |
Function
for WFDC12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WFD12_HUMAN, Q8WWY7Function: Antibacterial protein. Putative acid-stable proteinase inhibitor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for WFDC12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC12 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity |
NAS | 11779191 |
WFDC12 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for WFDC12:
Animal Models:
Mouse knock-out Wfdc12tm1Lex for WFDC12
1 MGI phenotypic allele  for Wfdc12 (no phenotypes)
WFDC12 for phenotypes About GeneDecksing
|
Pathways & Interactions
for WFDC12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFDC12
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for WFDC12 (ENSP000003618714) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042742 | defense response to bacterium |
ISS | -- |
WFDC12 for ontologies About GeneDecksing
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Drugs & Compounds
for WFDC12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WFDC12
Search CenterWatch for drugs/clinical trials and news about WFDC12 / WFD12
|
Transcripts
for WFDC12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WFDC12 gene: NM_080869.1 Unigene Cluster for WFDC12: WAP four-disulfide core domain 12 Hs.352180 Unigene Representative Sequence: AY0378031 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000372785(uc002xnf.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WFDC12 (NM_080869) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WFDC12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC12 |
Additional cDNA sequence: AY037803.1 AY358678.1 1 DOTS entry: DT.97816550 3 AceView cDNA sequences: NM_080869 AY037803 AY358678
GeneLoc Exon Structure
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Expression
for WFDC12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WFDC12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGAAACCA
About this image
See WFDC12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WFDC12
SOURCE GeneReport for Unigene cluster: Hs.352180
UniProtKB/Swiss-Prot: WFD12_HUMAN, Q8WWY7Tissue specificity: Highly expressed in prostate, skin, lung and esophagus. Weakly expressed in skeletal muscle,epididymis, kidney, trachea, salivary gland, testis and seminal vesicle
SABiosciences Custom PCR Arrays for WFDC12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat WFDC12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC12 |
Orthologs
for WFDC12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for WFDC12 (if available)
TreeFam Gene Tree for WFDC12 (if available) |
Paralogs
for WFDC12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WFDC12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WFDC12 (43752066 - 43753106 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WFDC12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC12 |
|
Disorders
/ Diseases
for WFDC12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WFDC12 for disorders About GeneDecksing
OMIM gene information: 609872
OMIM disorders: --
1  disease for WFDC12: About MalaCardsprostatitis
Export disorders for WFDC12 gene to outside databases
|
Publications
for WFDC12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WFDC12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WFDC12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel protease inhibitor gene that is highly expressed in the prostate. (PubMed id 11779191)1, 2, 3 Lundwall A. and Clauss A. (2002)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 3 Clauss A.... Lundwall A. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- The evolution of a genetic locus encoding small serine proteinase inhibitors. (PubMed id 15950183)1 Clauss A....Lundwall A. (2005)
- Comparative sequence analyses reveal rapid and divergent evolutionary changes of the WFDC locus in the primate lineage. (PubMed id 17267810)9 Hurle B....Green E.D. (2007)
- Species-specific alternative splicing of transgenic RNA in the mammary glands of pigs, rabbits, and mice. (PubMed id 10208871)9 Aigner B....Brem G. (1999)
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External Searches for WFDC12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing WFDC12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WFDC12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WFDC12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WFDC12 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for WFDC12 gene:
Search GeneIP for patents involving WFDC12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WFDC12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WFDC12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WFDC12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC12 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WFDC12 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for WFDC12 |
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 | | | WFDC12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC12 |
|  |  |  | | | | ThermoFisher Antibody for WFDC12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC12 |
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