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Aliases for WFDC12 Gene

Aliases for WFDC12 Gene

  • WAP Four-Disulfide Core Domain 12 2 3 5
  • Putative Protease Inhibitor WAP12 3 4
  • Whey Acidic Protein 2 3 4
  • C20orf122 3 4
  • WAP2 3 4
  • Chromosome 20 Open Reading Frame 122 2
  • Single WAP Motif Protein 2 3
  • Protease Inhibitor WAP2 3
  • DJ211D12.4 3
  • SWAM2 3

External Ids for WFDC12 Gene

Previous HGNC Symbols for WFDC12 Gene

  • C20orf122

Previous GeneCards Identifiers for WFDC12 Gene

  • GC20M043440
  • GC20M044390
  • GC20M044437
  • GC20M043185
  • GC20M043752
  • GC20M040493

Summaries for WFDC12 Gene

Entrez Gene Summary for WFDC12 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC12 Gene

WFDC12 (WAP Four-Disulfide Core Domain 12) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.

UniProtKB/Swiss-Prot for WFDC12 Gene

  • Antibacterial protein. Putative acid-stable proteinase inhibitor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC12 Gene

Genomics for WFDC12 Gene

Regulatory Elements for WFDC12 Gene

Enhancers for WFDC12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WFDC12 on UCSC Golden Path with GeneCards custom track

Genomic Location for WFDC12 Gene

Chromosome:
20
Start:
45,123,425 bp from pter
End:
45,124,465 bp from pter
Size:
1,041 bases
Orientation:
Minus strand

Genomic View for WFDC12 Gene

Genes around WFDC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC12 Gene

Proteins for WFDC12 Gene

  • Protein details for WFDC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWY7-WFD12_HUMAN
    Recommended name:
    WAP four-disulfide core domain protein 12
    Protein Accession:
    Q8WWY7
    Secondary Accessions:
    • Q5H980
    • Q9BR31

    Protein attributes for WFDC12 Gene

    Size:
    111 amino acids
    Molecular mass:
    12050 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WFDC12 Gene

Proteomics data for WFDC12 Gene at MOPED

Post-translational modifications for WFDC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WFDC12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC12 Gene

Domains & Families for WFDC12 Gene

Gene Families for WFDC12 Gene

Protein Domains for WFDC12 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for WFDC12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWY7

UniProtKB/Swiss-Prot:

WFD12_HUMAN :
  • Contains 1 WAP domain.
Domain:
  • Contains 1 WAP domain.
genes like me logo Genes that share domains with WFDC12: view

Function for WFDC12 Gene

Molecular function for WFDC12 Gene

UniProtKB/Swiss-Prot Function:
Antibacterial protein. Putative acid-stable proteinase inhibitor.
genes like me logo Genes that share phenotypes with WFDC12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WFDC12

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC12 Gene

Localization for WFDC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC12 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WFDC12 Gene COMPARTMENTS Subcellular localization image for WFDC12 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for WFDC12 Gene

Pathways & Interactions for WFDC12 Gene

SuperPathways for WFDC12 Gene

No Data Available

Interacting Proteins for WFDC12 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361871%0d%0a9606.ENSP00000430432%0d%0a
Selected Interacting proteins: ENSP00000361871 for WFDC12 Gene via STRING

Symbol External ID(s) Details
HDAC2

Gene Ontology (GO) - Biological Process for WFDC12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WFDC12 Gene

Drugs & Compounds for WFDC12 Gene

No Compound Related Data Available

Transcripts for WFDC12 Gene

mRNA/cDNA for WFDC12 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC12 Gene

WAP four-disulfide core domain 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC12 Gene

No ASD Table

Relevant External Links for WFDC12 Gene

GeneLoc Exon Structure for
WFDC12
ECgene alternative splicing isoforms for
WFDC12

Expression for WFDC12 Gene

mRNA expression in normal human tissues for WFDC12 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC12 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x19.3), Vagina (x13.0), Skin - Not Sun Exposed (Suprapubic) (x9.2), and Esophagus - Mucosa (x6.9).

Protein differential expression in normal tissues from HIPED for WFDC12 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WFDC12 Gene



SOURCE GeneReport for Unigene cluster for WFDC12 Gene Hs.352180

mRNA Expression by UniProt/SwissProt for WFDC12 Gene

Q8WWY7-WFD12_HUMAN
Tissue specificity: Highly expressed in prostate, skin, lung and esophagus. Weakly expressed in skeletal muscle, epididymis, kidney, trachea, salivary gland, testis and seminal vesicle.
genes like me logo Genes that share expression patterns with WFDC12: view

Protein tissue co-expression partners for WFDC12 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for WFDC12 Gene

Orthologs for WFDC12 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for WFDC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WFDC12 35
  • 98.2 (n)
  • 98.2 (a)
WFDC12 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wfdc12 36
  • 51 (a)
OneToOne
Species with no ortholog for WFDC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC12 Gene

ENSEMBL:
Gene Tree for WFDC12 (if available)
TreeFam:
Gene Tree for WFDC12 (if available)

Paralogs for WFDC12 Gene

(3) SIMAP similar genes for WFDC12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC12: view

No data available for Paralogs for WFDC12 Gene

Variants for WFDC12 Gene

Sequence variations from dbSNP and Humsavar for WFDC12 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1573699 -- 45,123,019(+) ATGGC(A/G)CCCTG downstream-variant-500B
rs1573700 -- 45,123,388(+) TTAGC(A/T)GGTTT downstream-variant-500B
rs2157361 -- 45,123,141(+) CCAAG(A/G)TGAAC downstream-variant-500B
rs6032006 -- 45,126,412(+) gatac(A/G)tgttg upstream-variant-2KB
rs6073652 -- 45,124,381(+) AACTC(A/C/T)TTCCA reference, missense

Variation tolerance for WFDC12 Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for WFDC12 Gene

Disorders for WFDC12 Gene

Relevant External Links for WFDC12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WFDC12

No disorders were found for WFDC12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC12 Gene

Publications for WFDC12 Gene

  1. Identification of a novel protease inhibitor gene that is highly expressed in the prostate. (PMID: 11779191) Lundwall A. … Clauss A. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 67
  2. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3
  3. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z. … Hurle B. (Mol. Biol. Evol. 2013) 3
  4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3
  5. Comparative sequence analyses reveal rapid and divergent evolutionary changes of the WFDC locus in the primate lineage. (PMID: 17267810) Hurle B. … Green E.D. (Genome Res. 2007) 23

Products for WFDC12 Gene

Sources for WFDC12 Gene

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