WFDC11 Gene
protein-coding GIFtS: 38
GCID: GC20M044277
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WAP four-disulfide core domain 11
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Aliases
for WFDC11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WAP Four-Disulfide Core Domain 111 2 | | WAP111 2 3 | | Protease Inhibitor WAP112 | | Protein WFDC112 |
Export aliases for WFDC11 gene to outside databasesPrevious GC identifers: GC20M043965 GC20M044916 GC20M044962 GC20M043710 GC20M041018 |
Summaries
for WFDC11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WFDC11:
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signaturemotif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a proteaseinhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric.This gene belongs to the telomeric cluster. (provided by RefSeq, Jul 2008)
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Genomic Views
for WFDC11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WFDC11 gene promoter:
GR GR-beta GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for WFDC11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12WFDC11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M044277: view genomic region
(about GC identifiers)
Start:
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44,277,202 bp from pter |
End:
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44,298,909 bp from pter |
Size:
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21,708 bases |
Orientation:
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minus strand |
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Proteins
for WFDC11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WFD11_HUMAN, Q8NEX6 (See
protein sequence)Recommended Name: Protein WFDC11 precursor Size: 87 amino acids; 10340 Da
Subcellular location: Secreted (Potential)
Miscellaneous: Although this protein was isolated in a region containing several WAP proteins and was defined as a WAPprotein, it does not contain a classical WAP domain
Secondary accessions: E1P624 Q5TGZ6Explore the universe of human proteins at neXtProt for WFDC11: NX_Q8NEX6
WFDC11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_671730.1
ENSEMBL proteins: ENSP00000348968 ENSP00000318753
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
WFDC11 for ontologies About GeneDecksing
WFDC11 Antibody Products:
Assay Products for WFDC11: |
Protein
Domains /
Families
for WFDC11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WFDC11 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NEX6ProtoNet protein and cluster: Q8NEX6 |
Function
for WFDC11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC11 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WFDC11 (NM_147197) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WFDC11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC11 |
|
Pathways & Interactions
for WFDC11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFDC11
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for WFDC11 (ENSP000003187534) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for WFDC11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WFDC11
Search CenterWatch for drugs/clinical trials and news about WFDC11 / WFD11
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Transcripts
for WFDC11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WFDC11 gene: NM_147197.2 Unigene Cluster for WFDC11: WAP four-disulfide core domain 11 Hs.374924 [show with all ESTs]Unigene Representative Sequence: BQ4328122 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000356562 ENST00000324384(uc002xpa.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC11 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WFDC11 (NM_147197) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WFDC11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC11 |
Additional cDNA sequence: AY047609.1 BC062670.1 1 DOTS entry: DT.97765012 4 AceView cDNA sequences: BC062670 AY047609 NM_147197 BQ432812
GeneLoc Exon Structure
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Expression
for WFDC11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WFDC11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACATTCTTCT
About this image
See WFDC11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WFDC11
SOURCE GeneReport for Unigene cluster: Hs.374924
SABiosciences Custom PCR Arrays for WFDC11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WFDC11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC11 |
Orthologs
for WFDC11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for WFDC11 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for WFDC11 (if available)
TreeFam Gene Tree for WFDC11 (if available) |
Paralogs
for WFDC11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WFDC11 gene
- WFDC92
3 SIMAP similar genes for WFDC11 using alignment to 1 protein entry: WFD11_HUMAN:WFDC10A WFDC10B WFDC9
WFDC11 for paralogs About GeneDecksing
|
Genomic Variants
for WFDC11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WFDC11 (44277202 - 44298909 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WFDC11: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC11 |
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Disorders
/ Diseases
for WFDC11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 WFDC11 for disorders About MalaCards
WFDC11 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: WFDC11 (1 document)
Export disorders for WFDC11 gene to outside databases
|
Publications
for WFDC11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WFDC11 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WFDC11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 2, 3 Clauss A.... Lundwall A. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The evolution of a genetic locus encoding small serine proteinase inhibitors. (PubMed id 15950183)1 Clauss A....Lundwall A. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for WFDC11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing WFDC11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WFDC11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WFDC11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WFDC11 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for WFDC11 gene:
Search GeneIP for patents involving WFDC11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WFDC11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WFDC11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WFDC11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC11 | | | OriGene Protein Over-expression Lysate for WFDC11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WFDC11 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WFDC11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WFDC11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC11 |
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 | | | WFDC11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for WFDC11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC11 |
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