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Aliases for WFDC11 Gene

Aliases for WFDC11 Gene

  • WAP Four-Disulfide Core Domain 11 2 3 5
  • WAP11 3 4
  • Protease Inhibitor WAP11 3
  • Protein WFDC11 3

External Ids for WFDC11 Gene

Previous GeneCards Identifiers for WFDC11 Gene

  • GC20M043965
  • GC20M044916
  • GC20M044962
  • GC20M043710
  • GC20M044277
  • GC20M041018

Summaries for WFDC11 Gene

Entrez Gene Summary for WFDC11 Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC11 Gene

WFDC11 (WAP Four-Disulfide Core Domain 11) is a Protein Coding gene. An important paralog of this gene is WFDC9.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC11 Gene

Genomics for WFDC11 Gene

Regulatory Elements for WFDC11 Gene

Enhancers for WFDC11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G045433 1.3 FANTOM5 ENCODE dbSUPER 4.8 +236.8 236772 0.8 ZFP64 ZNF140 ZNF384 ZNF697 ZNF316 NFE2 ZNF680 ZBTB11 ZNF426 REST SPATA25 DBNDD2 NCOA5 SYS1 SYS1-DBNDD2 WFDC11 KCNS1 WFDC6 GC20P045440 LOC105372631
GH20G045372 1.6 FANTOM5 Ensembl ENCODE 1.4 +296.7 296665 2.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZNF143 DEK SP5 ZHX2 DBNDD2 TP53TG5 PIGT SYS1 KCNS1 WFDC11 SYS1-DBNDD2 NDUFB4P10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WFDC11 on UCSC Golden Path with GeneCards custom track

Genomic Location for WFDC11 Gene

Chromosome:
20
Start:
45,648,563 bp from pter
End:
45,670,270 bp from pter
Size:
21,708 bases
Orientation:
Minus strand

Genomic View for WFDC11 Gene

Genes around WFDC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC11 Gene

Proteins for WFDC11 Gene

  • Protein details for WFDC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEX6-WFD11_HUMAN
    Recommended name:
    Protein WFDC11
    Protein Accession:
    Q8NEX6
    Secondary Accessions:
    • E1P624
    • Q5TGZ6

    Protein attributes for WFDC11 Gene

    Size:
    87 amino acids
    Molecular mass:
    10340 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Although this protein was isolated in a region containing several WAP proteins and was defined as a WAP protein, it does not contain a classical WAP domain.

neXtProt entry for WFDC11 Gene

Post-translational modifications for WFDC11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WFDC11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC11 Gene

Domains & Families for WFDC11 Gene

Gene Families for WFDC11 Gene

Protein Domains for WFDC11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WFDC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WFDC11: view

No data available for UniProtKB/Swiss-Prot for WFDC11 Gene

Function for WFDC11 Gene

genes like me logo Genes that share phenotypes with WFDC11: view

Animal Model Products

CRISPR Products

miRNA for WFDC11 Gene

miRTarBase miRNAs that target WFDC11

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WFDC11 Gene

Localization for WFDC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC11 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for WFDC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC11: view

Pathways & Interactions for WFDC11 Gene

SuperPathways for WFDC11 Gene

No Data Available

Interacting Proteins for WFDC11 Gene

Gene Ontology (GO) - Biological Process for WFDC11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WFDC11 Gene

Transcripts for WFDC11 Gene

mRNA/cDNA for WFDC11 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC11 Gene

WAP four-disulfide core domain 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC11 Gene

No ASD Table

Relevant External Links for WFDC11 Gene

GeneLoc Exon Structure for
WFDC11
ECgene alternative splicing isoforms for
WFDC11

Expression for WFDC11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WFDC11 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC11 Gene

This gene is overexpressed in Testis (x43.7).

NURSA nuclear receptor signaling pathways regulating expression of WFDC11 Gene:

WFDC11

SOURCE GeneReport for Unigene cluster for WFDC11 Gene:

Hs.374924
genes like me logo Genes that share expression patterns with WFDC11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WFDC11 Gene

Orthologs for WFDC11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for WFDC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WFDC11 34 35
  • 98.85 (n)
dog
(Canis familiaris)
Mammalia LOC102153638 34
  • 82.91 (n)
WFDC11 35
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wfdc11 35
  • 50 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WFDC11 35
  • 49 (a)
OneToOne
Species where no ortholog for WFDC11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC11 Gene

ENSEMBL:
Gene Tree for WFDC11 (if available)
TreeFam:
Gene Tree for WFDC11 (if available)

Paralogs for WFDC11 Gene

Paralogs for WFDC11 Gene

(3) SIMAP similar genes for WFDC11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC11: view

Variants for WFDC11 Gene

Sequence variations from dbSNP and Humsavar for WFDC11 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000051994 -- 45,648,158(+) GACCT(A/G)GAGCC downstream-variant-500B
rs1000212113 -- 45,664,243(+) GTGAC(C/G)CCTGC intron-variant
rs1000257159 -- 45,659,064(+) TGCAT(A/T)GTATT intron-variant
rs1000316312 -- 45,651,178(+) TTGAA(A/C)AAAAT intron-variant
rs1000475569 -- 45,654,187(+) TAAAG(C/T)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC11 Gene

Variant ID Type Subtype PubMed ID
esv3444784 CNV duplication 20981092
nsv1055601 CNV loss 25217958
nsv586081 CNV loss 21841781
nsv965877 CNV duplication 23825009

Variation tolerance for WFDC11 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WFDC11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WFDC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC11 Gene

Disorders for WFDC11 Gene

Relevant External Links for WFDC11

Genetic Association Database (GAD)
WFDC11
Human Genome Epidemiology (HuGE) Navigator
WFDC11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WFDC11

No disorders were found for WFDC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC11 Gene

Publications for WFDC11 Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z. … Hurle B. (Mol. Biol. Evol. 2013) 3 64

Products for WFDC11 Gene

Sources for WFDC11 Gene

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