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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WFDC10B Gene

protein-coding   GIFtS: 40
GCID: GC20M044314

WAP Four-Disulfide Core Domain 10B

  Search for WFDC10B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WAP Four-Disulfide Core Domain 10B1 2
WAP122 3
Protease Inhibitor WAP122
Protein WFDC10B2

External Ids:    HGNC: 204791   Entrez Gene: 2806642   Ensembl: ENSG000001829317   UniProtKB: Q8IUB33   

Export aliases for WFDC10B gene to outside databases

Previous GC identifers: GC20U900001 GC20M044951 GC20M044998 GC20M043746 GC20M041054


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WFDC10B Gene:
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP
signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions
as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters:
centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript
variants have been found for this gene, and they encode distinct isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for WFDC10B Gene: 
WFDC10B (WAP four-disulfide core domain 10B) is a protein-coding gene. GO annotations related to this gene include peptidase inhibitor activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WFDC10B gene promoter:
         AhR   RFX1   Pax-6   Arnt   Gfi-1   MEF-2A   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWFDC10B promoter sequence
   Search SABiosciences Chromatin IP Primers for WFDC10B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC10B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

WFDC10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WFDC10B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044314:  view genomic region     (about GC identifiers)

Start:
44,313,290 bp from pter      End:
44,333,658 bp from pter
Size:
20,369 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WF10B_HUMAN, Q8IUB3 (See protein sequence)
Recommended Name: Protein WFDC10B precursor  
Size: 73 amino acids; 8325 Da
Subcellular location: Secreted (Potential)
Secondary accessions: A6PVD7 Q0VAG0 Q0VAG1 Q5TGZ5 Q8IUB4
Alternative splicing: 2 isoforms:  Q8IUB3-1   Q8IUB3-2   

Explore the universe of human proteins at neXtProt for WFDC10B: NX_Q8IUB3

Explore proteomics data for WFDC10B at MOPED 

WFDC10B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

WFDC10B Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_742003.1  NP_742143.1  

ENSEMBL proteins: 
 ENSP00000327628   ENSP00000337466  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

WFDC10B for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
WFDC: WAP four-disulfide core domain containing

1 InterPro protein domain:
 IPR008197 WAP-type_4-diS_core

Graphical View of Domain Structure for InterPro Entry Q8IUB3

ProtoNet protein and cluster: Q8IUB3

1 Blocks protein domain: IPB008197 4-disulphide core signature

UniProtKB/Swiss-Prot: WF10B_HUMAN, Q8IUB3
Similarity: Contains 1 WAP domain


WFDC10B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030414peptidase inhibitor activity IEA--
     
WFDC10B for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for WFDC10B:
 Cells with protrusions 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFDC10B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WFDC10B (WF10B)

Search CenterWatch for drugs/clinical trials and news about WFDC10B / WF10B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WFDC10B gene (2 alternative transcripts): 
NM_172006.2  NM_172131.2  

Unigene Cluster for WFDC10B:

WAP four-disulfide core domain 10B
Hs.237392  [show with all ESTs]
Unigene Representative Sequence: NM_172006
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000330523(uc002xpb.3) ENST00000335769(uc002xpc.3)
miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AF454506.1 AF454507.1 BC121071.1 BC121072.1 

3 DOTS entries:

DT.100015336  DT.100015335  DT.65286404 

6 AceView cDNA sequences:

NM_172131 NM_172006 AF454507 AF454506 BV192880 BI035811 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for WFDC10B    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4
SP1:                        
SP2:              -         


ECgene alternative splicing isoforms for WFDC10B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WFDC10B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
WFDC10B Expression
About this image


See WFDC10B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WFDC10B

SOURCE GeneReport for Unigene cluster: Hs.237392

UniProtKB/Swiss-Prot: WF10B_HUMAN, Q8IUB3
Tissue specificity: Ubiquitously expressed

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for WFDC10B gene from 1/2 species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia WFDC10B1 WAP four-disulfide core domain 10B 77.46(n)
63.38(a)
  100685937  XM_003433215.1  XP_003433263.1 


ENSEMBL Gene Tree for WFDC10B (if available)
TreeFam Gene Tree for WFDC10B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for WFDC10B gene
3 SIMAP similar genes for WFDC10B using alignment to 1 protein entry:     WF10B_HUMAN:
WFDC10A    WFDC11    WFDC9

WFDC10B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/366 SNPs in WFDC10B are shown (see all 366)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs22812111,2
C,F,A,H--44312858(+) ATTATC/TCTCAT 2 -- ds500116Minor allele frequency- T:0.23NS EA NA WA 1150
rs801530091,2
C,F--44312929(+) CCAAGG/ACTAAG 2 -- ds50011Minor allele frequency- A:0.03WA 118
rs1863346281,2
--44312950(+) CAGTGC/TTTGGG 2 -- ds50010--------
rs1910322951,2
--44312957(+) TGGGGC/GCCTCC 2 -- ds50010--------
rs18257751,2
C,F,O,A,H--44312991(+) TGCCAC/TCCATC 2 -- ds500110Minor allele frequency- N:0.00EA NA WA 584
rs1465248131,2
--44312992(+) GCCACC/TCATCT 2 -- ds50010--------
rs60738561,2
C,F,A,H--44313020(+) TCTGAT/CTCCAG 2 -- ds50018Minor allele frequency- C:0.47NA WA CSA 19
rs1153527811,2
C,F--44313058(+) GAGACG/ACTGCA 2 -- ds50011Minor allele frequency- A:0.03WA 118
rs1436628021,2
--44313117(+) CAAGGC/GGCTGG 2 -- ds50010--------
rs1160481271,2
C,F--44313160(+) AAAGAA/GGGAGA 2 -- ds50011Minor allele frequency- G:0.03WA 118

HapMap Linkage Disequilibrium report for WFDC10B (44313290 - 44333658 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for WFDC10B:    About this table     
Variant IDTypeSubtypePubMed ID
nsv525287CNV Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for WFDC10B gene integrated from 9 sources:
(articles sorted by number of sources associating them with WFDC10B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 2, 3 Clauss A.... Lundwall A. (2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  4. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PubMed id 15950183)1 Clauss A....Lundwall A. (2005)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 280664 HGNC: 20479 AceView: WFDC10B Ensembl:ENSG00000182931 euGenes: HUgn280664
ECgene: WFDC10B H-InvDB: WFDC10B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for WFDC10B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for WFDC10B gene:
Search GeneIP for patents involving WFDC10B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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