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Aliases for WFDC10B Gene

Aliases for WFDC10B Gene

  • WAP Four-Disulfide Core Domain 10B 2 3 5
  • WAP12 3 4
  • Protease Inhibitor WAP12 3

External Ids for WFDC10B Gene

Previous GeneCards Identifiers for WFDC10B Gene

  • GC20U900001
  • GC20M044951
  • GC20M044998
  • GC20M043746
  • GC20M044314
  • GC20M041054

Summaries for WFDC10B Gene

Entrez Gene Summary for WFDC10B Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC10B Gene

WFDC10B (WAP Four-Disulfide Core Domain 10B) is a Protein Coding gene. GO annotations related to this gene include peptidase inhibitor activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC10B Gene

Genomics for WFDC10B Gene

Regulatory Elements for WFDC10B Gene

Enhancers for WFDC10B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WFDC10B on UCSC Golden Path with GeneCards custom track

Genomic Location for WFDC10B Gene

45,684,651 bp from pter
45,705,019 bp from pter
20,369 bases
Minus strand

Genomic View for WFDC10B Gene

Genes around WFDC10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC10B Gene

Proteins for WFDC10B Gene

  • Protein details for WFDC10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein WFDC10B
    Protein Accession:
    Secondary Accessions:
    • A6PVD7
    • Q0VAG0
    • Q0VAG1
    • Q5TGZ5
    • Q8IUB4

    Protein attributes for WFDC10B Gene

    73 amino acids
    Molecular mass:
    8325 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WFDC10B Gene


neXtProt entry for WFDC10B Gene

Proteomics data for WFDC10B Gene at MOPED

Post-translational modifications for WFDC10B Gene

No Post-translational modifications

Other Protein References for WFDC10B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC10B Gene

Domains & Families for WFDC10B Gene

Gene Families for WFDC10B Gene

Protein Domains for WFDC10B Gene


Suggested Antigen Peptide Sequences for WFDC10B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 WAP domain.
  • Contains 1 WAP domain.
genes like me logo Genes that share domains with WFDC10B: view

Function for WFDC10B Gene

genes like me logo Genes that share phenotypes with WFDC10B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC10B Gene

Localization for WFDC10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC10B Gene


Subcellular locations from

Jensen Localization Image for WFDC10B Gene COMPARTMENTS Subcellular localization image for WFDC10B gene
Compartment Confidence
extracellular 4
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for WFDC10B Gene

Pathways & Interactions for WFDC10B Gene

SuperPathways for WFDC10B Gene

No Data Available

Interacting Proteins for WFDC10B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000337466 for WFDC10B Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for WFDC10B Gene


No data available for Pathways by source and SIGNOR curated interactions for WFDC10B Gene

Drugs & Compounds for WFDC10B Gene

No Compound Related Data Available

Transcripts for WFDC10B Gene

mRNA/cDNA for WFDC10B Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC10B Gene

WAP four-disulfide core domain 10B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC10B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4
SP2: -

Relevant External Links for WFDC10B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC10B Gene

mRNA expression in normal human tissues for WFDC10B Gene

mRNA differential expression in normal tissues according to GTEx for WFDC10B Gene

This gene is overexpressed in Bladder (x13.1), Testis (x11.1), and Skin - Sun Exposed (Lower leg) (x4.0).

SOURCE GeneReport for Unigene cluster for WFDC10B Gene Hs.237392

mRNA Expression by UniProt/SwissProt for WFDC10B Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with WFDC10B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for WFDC10B Gene

Orthologs for WFDC10B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for WFDC10B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WFDC10B 36
  • 98 (a)
Species with no ortholog for WFDC10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC10B Gene

Gene Tree for WFDC10B (if available)
Gene Tree for WFDC10B (if available)

Paralogs for WFDC10B Gene

(3) SIMAP similar genes for WFDC10B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC10B: view

No data available for Paralogs for WFDC10B Gene

Variants for WFDC10B Gene

Sequence variations from dbSNP and Humsavar for WFDC10B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs232729 - 45,685,970(+) GGACA(A/G)GCAGC intron-variant, reference, missense
rs1825775 -- 45,684,352(+) TGCCA(C/T)CCATC downstream-variant-500B
rs392034 -- 45,698,591(-) ttggg(G/T)ttttt intron-variant
rs1487312 -- 45,685,394(+) TCTCC(A/G)TCACT intron-variant
rs1487313 -- 45,685,598(+) ATTGT(C/G)TTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC10B Gene

Variant ID Type Subtype PubMed ID
nsv525287 CNV Loss 19592680

Variation tolerance for WFDC10B Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WFDC10B Gene

Disorders for WFDC10B Gene

Relevant External Links for WFDC10B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WFDC10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC10B Gene

Publications for WFDC10B Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z. … Hurle B. (Mol. Biol. Evol. 2013) 3
  4. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PMID: 15950183) Clauss A. … Lundwall A. (Biochem. Biophys. Res. Commun. 2005) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for WFDC10B Gene

Sources for WFDC10B Gene