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Aliases for WFDC10A Gene

Aliases for WFDC10A Gene

  • WAP Four-Disulfide Core Domain 10A 2 3
  • Putative Protease Inhibitor WAP10A 3 4
  • C20orf146 3 4
  • WAP10 3 4
  • WAP Four-Disulfide Core Domain Protein 10A 3
  • Chromosome 20 Open Reading Frame 146 2
  • DJ688G8.3 3

External Ids for WFDC10A Gene

Previous HGNC Symbols for WFDC10A Gene

  • C20orf146

Previous GeneCards Identifiers for WFDC10A Gene

  • GC20P043946
  • GC20P044896
  • GC20P044943
  • GC20P043691
  • GC20P044258
  • GC20P040999

Summaries for WFDC10A Gene

Entrez Gene Summary for WFDC10A Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC10A Gene

WFDC10A (WAP Four-Disulfide Core Domain 10A) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC10A Gene

Genomics for WFDC10A Gene

Regulatory Elements for WFDC10A Gene

Genomic Location for WFDC10A Gene

45,629,526 bp from pter
45,631,196 bp from pter
1,671 bases
Plus strand

Genomic View for WFDC10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WFDC10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC10A Gene

Proteins for WFDC10A Gene

  • Protein details for WFDC10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 10A
    Protein Accession:
    Secondary Accessions:
    • A2RRE9
    • Q5TGZ7

    Protein attributes for WFDC10A Gene

    79 amino acids
    Molecular mass:
    8943 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WFDC10A Gene

Proteomics data for WFDC10A Gene at MOPED

Post-translational modifications for WFDC10A Gene

No Post-translational modifications

Other Protein References for WFDC10A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC10A Gene

Domains for WFDC10A Gene

Gene Families for WFDC10A Gene

Protein Domains for WFDC10A Gene


Suggested Antigen Peptide Sequences for WFDC10A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 WAP domain.
  • Contains 1 WAP domain.
genes like me logo Genes that share domains with WFDC10A: view

Function for WFDC10A Gene

Gene Ontology (GO) - Molecular Function for WFDC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity --
genes like me logo Genes that share ontologies with WFDC10A: view

Phenotypes for WFDC10A Gene

GenomeRNAi human phenotypes for WFDC10A:
genes like me logo Genes that share phenotypes with WFDC10A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC10A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC10A Gene

Localization for WFDC10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC10A Gene


Subcellular locations from

Jensen Localization Image for WFDC10A Gene COMPARTMENTS Subcellular localization image for WFDC10A gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for WFDC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC10A: view

Pathways for WFDC10A Gene

SuperPathways for WFDC10A Gene

No Data Available

Interacting Proteins for WFDC10A Gene

Gene Ontology (GO) - Biological Process for WFDC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with WFDC10A: view

No data available for Pathways by source for WFDC10A Gene

Transcripts for WFDC10A Gene

mRNA/cDNA for WFDC10A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC10A Gene

WAP four-disulfide core domain 10A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC10A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC10A Gene

No ASD Table

Relevant External Links for WFDC10A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC10A Gene

mRNA expression in normal human tissues for WFDC10A Gene

SOURCE GeneReport for Unigene cluster for WFDC10A Gene Hs.199380

genes like me logo Genes that share expressions with WFDC10A: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for WFDC10A Gene

Orthologs for WFDC10A Gene

This gene was present in the common ancestor of mammals.

Orthologs for WFDC10A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WFDC10A 35
  • 99.58 (n)
  • 100 (a)
WFDC10A 36
  • 100 (a)
(Bos Taurus)
Mammalia WFDC10A 36
  • 60 (a)
(Canis familiaris)
Mammalia WFDC10A 36
  • 63 (a)
(Mus musculus)
Mammalia Wfdc10 36
  • 31 (a)
Species with no ortholog for WFDC10A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC10A Gene

Gene Tree for WFDC10A (if available)
Gene Tree for WFDC10A (if available)

Paralogs for WFDC10A Gene

(2) SIMAP similar genes for WFDC10A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC10A: view

No data available for Paralogs for WFDC10A Gene

Variants for WFDC10A Gene

Structural Variations from Database of Genomic Variants (DGV) for WFDC10A Gene

Variant ID Type Subtype PubMed ID
nsv7342 OTHER Inversion 18451855
nsv912893 CNV Loss 21882294

Relevant External Links for WFDC10A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for WFDC10A Gene

Disorders for WFDC10A Gene

No disorders were found for WFDC10A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for WFDC10A Gene

Publications for WFDC10A Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PMID: 15950183) Clauss A. … Lundwall A. (Biochem. Biophys. Res. Commun. 2005) 3
  5. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z. … Hurle B. (Mol. Biol. Evol. 2013) 3

Products for WFDC10A Gene

Sources for WFDC10A Gene

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