WFDC10A Gene
protein-coding GIFtS: 38
GCID: GC20P044258
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WAP four-disulfide core domain 10A(Previous name: chromosome 20 open reading frame 146 )
(Previous symbol: C20orf146)
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Aliases
for WFDC10A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WAP Four-Disulfide Core Domain 10A1 2 | | Putative Protease Inhibitor WAP10A2 3 | | C20orf1461 2 3 | | Chromosome 20 Open Reading Frame 1461 | | WAP101 2 3 | | WAP Four-Disulfide Core Domain Protein 10A2 | | DJ688G8.31 | | |
Export aliases for WFDC10A gene to outside databasesPrevious GC identifers: GC20P043946 GC20P044896 GC20P044943 GC20P043691 GC20P040999 |
Summaries
for WFDC10A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WFDC10A:
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signaturemotif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a proteaseinhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric.This gene belongs to the telomeric cluster. (provided by RefSeq, Jul 2008)
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Genomic Views
for WFDC10A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WFDC10A gene promoter:
Ik-2 HNF-1 STAT3 Nkx5-1 HNF-3beta HNF-1A Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WFDC10A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC10A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.11WFDC10A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P044258: view genomic region
(about GC identifiers)
Start:
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44,258,165 bp from pter |
End:
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44,259,835 bp from pter |
Size:
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1,671 bases |
Orientation:
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plus strand |
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Proteins
for WFDC10A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WF10A_HUMAN, Q9H1F0 (See
protein sequence)Recommended Name: WAP four-disulfide core domain protein 10A precursor Size: 79 amino acids; 8943 Da
Subcellular location: Secreted (Potential)
Secondary accessions: A2RRE9 Q5TGZ7Explore the universe of human proteins at neXtProt for WFDC10A: NX_Q9H1F0
WFDC10A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_542791.1
ENSEMBL proteins: ENSP00000361726
Human Recombinant Protein Products for WFDC10A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005576 | extracellular region |
IEA | -- |
WFDC10A for ontologies About GeneDecksing
WFDC10A Antibody Products:
Assay Products for WFDC10A: |
Protein
Domains /
Families
for WFDC10A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WFDC10A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H1F0ProtoNet protein and cluster: Q9H1F0 1 Blocks protein family: IPB008197 4-disulphide core signature
UniProtKB/Swiss-Prot: WF10A_HUMAN, Q9H1F0Similarity: Contains 1 WAP domain |
Function
for WFDC10A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0004867 | serine-type endopeptidase inhibitor activity |
IEA | -- |
WFDC10A for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for WFDC10A:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC10A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC10A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WFDC10A (NM_080753) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WFDC10A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC10A |
|
Pathways & Interactions
for WFDC10A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFDC10A
|
Drugs & Compounds
for WFDC10A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WFDC10A
Search CenterWatch for drugs/clinical trials and news about WFDC10A / WF10A
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Transcripts
for WFDC10A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WFDC10A gene: NM_080753.2 Unigene Cluster for WFDC10A: WAP four-disulfide core domain 10A Hs.199380 [show with all ESTs]Unigene Representative Sequence: BG1944251 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000372643(uc002xoz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC10A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC10A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WFDC10A (NM_080753) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WFDC10A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC10A |
Additional cDNA sequence: AY038182.1 BC131579.1 1 DOTS entry: DT.100000412 7 AceView cDNA sequences: AY038182 NM_080753 CR598861 AI673291 BX380556 BX330465 BG181924
GeneLoc Exon Structure
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Expression
for WFDC10A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WFDC10A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCATCCTGT
About this image
See WFDC10A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WFDC10A
SOURCE GeneReport for Unigene cluster: Hs.199380
SABiosciences Custom PCR Arrays for WFDC10A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC10A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat WFDC10A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC10A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC10A |
Orthologs
for WFDC10A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
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ENSEMBL Gene Tree for WFDC10A (if available)
TreeFam Gene Tree for WFDC10A (if available) |
Paralogs
for WFDC10A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WFDC10A gene
- WFDC10B2
2 SIMAP similar genes for WFDC10A using alignment to 1 protein entry: WF10A_HUMAN:WFDC10B WFDC11
WFDC10A for paralogs About GeneDecksing
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Genomic Variants
for WFDC10A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WFDC10A (44258165 - 44259835 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WFDC10A
1 Inversion: 37231 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC10A |
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Disorders
/ Diseases
for WFDC10A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WFDC10A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WFDC10A gene integrated from 9 sources:
(articles sorted by number of sources associating them with WFDC10A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 2, 3 Clauss A.... Lundwall A. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- The evolution of a genetic locus encoding small serine proteinase inhibitors. (PubMed id 15950183)1 Clauss A....Lundwall A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for WFDC10A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing WFDC10A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing WFDC10A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WFDC10A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WFDC10A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for WFDC10A gene:
Search GeneIP for patents involving WFDC10A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WFDC10A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WFDC10A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WFDC10A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC10A | | | OriGene Protein Over-expression Lysate for WFDC10A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WFDC10A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC10A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC10A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for WFDC10A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WFDC10A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC10A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC10A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WFDC10A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC10A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC10A |
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 | | | WFDC10A Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for WFDC10A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC10A |
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