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Aliases for WFDC10A Gene

Aliases for WFDC10A Gene

  • WAP Four-Disulfide Core Domain 10A 2 3 5
  • Putative Protease Inhibitor WAP10A 3 4
  • C20orf146 3 4
  • WAP10 3 4
  • WAP Four-Disulfide Core Domain Protein 10A 3
  • Chromosome 20 Open Reading Frame 146 2
  • DJ688G8.3 3

External Ids for WFDC10A Gene

Previous HGNC Symbols for WFDC10A Gene

  • C20orf146

Previous GeneCards Identifiers for WFDC10A Gene

  • GC20P043946
  • GC20P044896
  • GC20P044943
  • GC20P043691
  • GC20P044258
  • GC20P040999

Summaries for WFDC10A Gene

Entrez Gene Summary for WFDC10A Gene

  • This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for WFDC10A Gene

WFDC10A (WAP Four-Disulfide Core Domain 10A) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity. An important paralog of this gene is WFDC10B.

Additional gene information for WFDC10A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC10A Gene

Genomics for WFDC10A Gene

Regulatory Elements for WFDC10A Gene

Enhancers for WFDC10A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H045629 0.7 ENCODE 0.7 +0.2 151 0.2 SMARCA5 CTCF TRIM22 MAX ELF1 RAD21 GATA3 ZNF366 SMC3 CREB1 WFDC9 WFDC10A
GH20H045610 0.6 ENCODE 0.4 -18.2 -18181 1.6 MAZ RFX1 HLF CEBPG GABPA ZFHX2 GATA3 EGR1 EGR2 WFDC3 WFDC13 ENSG00000237464 WFDC10A WFDC8
GH20H045583 0.2 ENCODE 0.2 -45.8 -45750 0.2 WFDC8 WFDC10A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WFDC10A on UCSC Golden Path with GeneCards custom track

Genomic Locations for WFDC10A Gene

Genomic Locations for WFDC10A Gene
1,671 bases
Plus strand

Genomic View for WFDC10A Gene

Genes around WFDC10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC10A Gene

Proteins for WFDC10A Gene

  • Protein details for WFDC10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WAP four-disulfide core domain protein 10A
    Protein Accession:
    Secondary Accessions:
    • A2RRE9
    • Q5TGZ7

    Protein attributes for WFDC10A Gene

    79 amino acids
    Molecular mass:
    8943 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WFDC10A Gene

Post-translational modifications for WFDC10A Gene

No Post-translational modifications

Other Protein References for WFDC10A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WFDC10A Gene

Domains & Families for WFDC10A Gene

Gene Families for WFDC10A Gene

Protein Domains for WFDC10A Gene


Suggested Antigen Peptide Sequences for WFDC10A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WFDC10A: view

No data available for UniProtKB/Swiss-Prot for WFDC10A Gene

Function for WFDC10A Gene

Gene Ontology (GO) - Molecular Function for WFDC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFDC10A: view
genes like me logo Genes that share phenotypes with WFDC10A: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC10A Gene

Localization for WFDC10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC10A Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC10A gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for WFDC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with WFDC10A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WFDC10A Gene

Pathways & Interactions for WFDC10A Gene

SuperPathways for WFDC10A Gene

No Data Available

Interacting Proteins for WFDC10A Gene

Gene Ontology (GO) - Biological Process for WFDC10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with WFDC10A: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC10A Gene

Drugs & Compounds for WFDC10A Gene

No Compound Related Data Available

Transcripts for WFDC10A Gene

mRNA/cDNA for WFDC10A Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WFDC10A Gene

WAP four-disulfide core domain 10A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC10A Gene

No ASD Table

Relevant External Links for WFDC10A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WFDC10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WFDC10A Gene

NURSA nuclear receptor signaling pathways regulating expression of WFDC10A Gene:


SOURCE GeneReport for Unigene cluster for WFDC10A Gene:

genes like me logo Genes that share expression patterns with WFDC10A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WFDC10A Gene

Orthologs for WFDC10A Gene

This gene was present in the common ancestor of mammals.

Orthologs for WFDC10A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WFDC10A 33 34
  • 99.58 (n)
(Canis familiaris)
Mammalia WFDC10A 34
  • 63 (a)
(Bos Taurus)
Mammalia WFDC10A 34
  • 60 (a)
(Mus musculus)
Mammalia Wfdc10 34
  • 31 (a)
Species where no ortholog for WFDC10A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WFDC10A Gene

Gene Tree for WFDC10A (if available)
Gene Tree for WFDC10A (if available)

Paralogs for WFDC10A Gene

Paralogs for WFDC10A Gene

(2) SIMAP similar genes for WFDC10A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WFDC10A: view

Variants for WFDC10A Gene

Sequence variations from dbSNP and Humsavar for WFDC10A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000119134 -- 45,630,272(+) GACGG(C/T)AGGTG intron-variant
rs1000402050 -- 45,631,554(+) CTCCT(C/T)AGCCT downstream-variant-500B, upstream-variant-2KB
rs1001774922 -- 45,631,065(+) CTCTA(A/T)CCAAG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1002122558 -- 45,631,273(+) TCTTG(C/T)GTCCT downstream-variant-500B, upstream-variant-2KB
rs1002405629 -- 45,630,191(+) TGAGA(A/G)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC10A Gene

Variant ID Type Subtype PubMed ID
nsv7342 OTHER inversion 18451855
nsv586081 CNV loss 21841781
nsv1056102 CNV loss 25217958

Variation tolerance for WFDC10A Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WFDC10A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC10A Gene

Disorders for WFDC10A Gene

Relevant External Links for WFDC10A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WFDC10A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC10A Gene

Publications for WFDC10A Gene

  1. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A … Lundwall A (The Biochemical journal 2002) 2 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Reproduction and immunity-driven natural selection in the human WFDC locus. (PMID: 23292442) Ferreira Z … Hurle B (Molecular biology and evolution 2013) 3 60
  5. The evolution of a genetic locus encoding small serine proteinase inhibitors. (PMID: 15950183) Clauss A … Lundwall A (Biochemical and biophysical research communications 2005) 3 60

Products for WFDC10A Gene

Sources for WFDC10A Gene

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