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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WFDC1 Gene

protein-coding   GIFtS: 51
GCID: GC16P084328

WAP Four-Disulfide Core Domain 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WAP Four-Disulfide Core Domain 11 2
PS202 3 5
Prostate Stromal Protein Ps202 3
Ps20 Growth Inhibitor2 3
WAP Four-Disulfide Core Domain 1 Homolog2
WAP Four-Disulfide Core Domain Protein 12

External Ids:    HGNC: 154661   Entrez Gene: 581892   Ensembl: ENSG000001031757   OMIM: 6053225   UniProtKB: Q9HC573   

Export aliases for WFDC1 gene to outside databases

Previous GC identifers: GC16P075178 GC16P085295 GC16P084067 GC16P084108 GC16P082885 GC16P070082


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WFDC1 Gene:
This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core
domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a
protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of
heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is
downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded
protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus
infection. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for WFDC1 Gene: 
WFDC1 (WAP four-disulfide core domain 1) is a protein-coding gene. Diseases associated with WFDC1 include prostatitis, and wilms tumor. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and molecular_function.

UniProtKB/Swiss-Prot: WFDC1_HUMAN, Q9HC57
Function: Has growth inhibitory activity (By similarity)

Gene Wiki entry for WFDC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WFDC1 gene promoter:
         NF-1   Pbx1a   MyoD   HSF1 (long)   C/EBPalpha   PPAR-gamma1   HSF2   HSF1short   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWFDC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for WFDC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

WFDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WFDC1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P084328:  view genomic region     (about GC identifiers)

Start:
84,328,252 bp from pter      End:
84,363,450 bp from pter
Size:
35,199 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WFDC1_HUMAN, Q9HC57 (See protein sequence)
Recommended Name: WAP four-disulfide core domain protein 1 precursor  
Size: 220 amino acids; 23977 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=AAG15263.1; Type=Frameshift; Positions=166, 173;
Secondary accessions: D3DUL7 Q8NC27 Q9HAU1

Explore the universe of human proteins at neXtProt for WFDC1: NX_Q9HC57

Explore proteomics data for WFDC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HC57

  • WFDC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WFDC1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269395.1  NP_001269396.1  NP_067020.2  

    ENSEMBL proteins: 
     ENSP00000219454   ENSP00000456920  

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    Cloud-Clone Corp. Proteins for WFDC1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space NAS10967136

    WFDC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WFDC: WAP four-disulfide core domain containing

    1 InterPro protein domain:
     IPR008197 WAP-type_4-diS_core

    Graphical View of Domain Structure for InterPro Entry Q9HC57

    ProtoNet protein and cluster: Q9HC57

    1 Blocks protein domain: IPB008197 4-disulphide core signature

    UniProtKB/Swiss-Prot: WFDC1_HUMAN, Q9HC57
    Similarity: Contains 1 WAP domain


    WFDC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WFDC1_HUMAN, Q9HC57
    Function: Has growth inhibitory activity (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0030414peptidase inhibitor activity ----
         
    WFDC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WFDC1:
     Decreased nuclei size in G2M 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WFDC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for WFDC1 (ENSP000002194544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZRENSP000003389344STRING: ENSP00000338934
    FOSL1ENSP000003101704STRING: ENSP00000310170
    RAB40BENSP000002693474STRING: ENSP00000269347
    XRCC2ENSP000003522714STRING: ENSP00000352271
    ZNF677ENSP000003343944STRING: ENSP00000334394
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth ----
    GO:0030308negative regulation of cell growth NAS10967136
    GO:0032355response to estradiol stimulus IEA--
    GO:0042493response to drug IEA--
    GO:0050680negative regulation of epithelial cell proliferation IEA--

    WFDC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WFDC1

    Search CenterWatch for drugs/clinical trials and news about WFDC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WFDC1 gene (3 alternative transcripts): 
    NM_001282466.1  NM_001282467.1  NM_021197.3  

    Unigene Cluster for WFDC1:

    WAP four-disulfide core domain 1
    Hs.36688  [show with all ESTs]
    Unigene Representative Sequence: AK128711
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219454(uc002fhv.3 uc002fhw.3) ENST00000568638 ENST00000567056

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF169631.1 AF302109.1 AK075061.1 AK128711.1 AL713785.1 BC029159.1 

    4 DOTS entries:

    DT.212641  DT.100777273  DT.101962741  DT.120691337 

    24/110 AceView cDNA sequences (see all 110):

    BF725477 AI190199 BF447098 CR608359 CR610530 W25322 CR615719 AI224935 
    BF449060 AI360465 AI246305 CR604862 CR595501 AL545137 AI289243 AI925090 
    AI142995 BM663231 AW052100 BQ678502 AI742302 BQ671964 AI025573 AI859156 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WFDC1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            


    ECgene alternative splicing isoforms for WFDC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WFDC1 expression in normal human tissues (normalized intensities)      WFDC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGCATTTC
    WFDC1 Expression
    About this image


    WFDC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Lower Urinary Tract (Urinary System)
             bladder   
     
     Eye (Sensory Organs)
             lens   
     
     Neural Tube (Nervous System)
             Prosencephalon
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived hematopoietic stem cells
     
     Endothelium (Cardiovascular System)
             aorta   

    See WFDC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WFDC1

    SOURCE GeneReport for Unigene cluster: Hs.36688
        SABiosciences Custom PCR Arrays for WFDC1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for WFDC1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wfdc11 , 5 WAP four-disulfide core domain 11, 5 79.59(n)1
    83.73(a)1
      8 (68.15 cM)5
    678661  NM_023395.21  NP_075884.11 
     1196663655 
    chicken
    (Gallus gallus)
    Aves WFDC11 WAP four-disulfide core domain 1 67.15(n)
    65.38(a)
      395238  NM_204554.1  NP_989885.1 
    lizard
    (Anolis carolinensis)
    Reptilia WFDC16
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL343849.1(68594-75410)
    zebrafish
    (Danio rerio)
    Actinopterygii wfdc11 WAP four-disulfide core domain 1 62.94(n)
    62.44(a)
      560860  NM_001100000.1  NP_001093470.1 


    ENSEMBL Gene Tree for WFDC1 (if available)
    TreeFam Gene Tree for WFDC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1283 SNPs in WFDC1 are shown (see all 1283)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116438701,2,4
    C,F,HA breast cancer sample4 --84351952(+) AGGAGG/ATGTTA 2 /M /V mis1 ese38Minor allele frequency- A:0.01NS NA EU 6388
    rs1896027891,2
    --84326435(+) TCTCAC/TGCTTG 1 -- us2k10--------
    rs1821257001,2
    --84326436(+) CTCACG/TCTTGG 1 -- us2k10--------
    rs755015841,2
    C,F--84326459(+) ACAGGA/TCTCTG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1867289551,2
    --84326543(+) ACCTGC/TTTATA 1 -- us2k10--------
    rs2008762511,2
    --84326629(+) TTTAA-/GGGTTT 1 -- us2k10--------
    rs2008522041,2
    C--84326644(+) TTTTTG/TATACA 1 -- us2k10--------
    rs1911704181,2
    --84326651(+) TACAGA/GGTCTT 1 -- us2k10--------
    rs1836989591,2
    C--84326652(+) ACAGGA/C/GTCTTG 1 -- us2k10--------
    rs8897341,2
    C,F--84326666(-) cctggG/Ttcaca 1 -- us2k14Minor allele frequency- T:0.14NA 126

    HapMap Linkage Disequilibrium report for WFDC1 (84328252 - 84363450 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for WFDC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714827CNV Deletion23290073
    nsv523416CNV Loss19592680
    nsv833310CNV Loss17160897
    nsv907066CNV Gain21882294
    nsv907065CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605322    OMIM disorders: --

    9 diseases for WFDC1:    About MalaCards
    prostatitis    wilms tumor    hiv type 1    retinoblastoma
    rheumatoid arthritis    arthritis    hepatocellular carcinoma    prostate cancer
    melanoma


    WFDC1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for WFDC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 11 10 14522910 (3), 18842679 (2), 17210724 (1)

    Genetic Association Database (GAD): WFDC1
    Human Genome Epidemiology (HuGE) Navigator: WFDC1 (2 documents)

    Export disorders for WFDC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WFDC1 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with WFDC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers. (PubMed id 10967136)1, 2, 3, 9 Larsen M....Rowley D.R. (2000)
    2. Supervised machine learning and logistic regression i dentifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis. (PubMed id 20090771)1, 4 Briggs F.B....Barcellos L.F. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. (PubMed id 14522910)1, 9 McAlhany S.J....Rowley D.R. (2003)
    6. WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection. (PubMed id 17942534)1, 9 Alvarez R....Vyakarnam A. (2008)
    7. Modulated expression of WFDC1 during carcinogenesis and cellular senescence. (PubMed id 18842679)1, 9 Madar S....Rotter V. (2008)
    8. PAX2 Expression in Ovarian Cancer. (PubMed id 23502471)1 Song H....Wong K.K. (2013)
    9. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    10. Immunotherapy of prostate cancer: identification of ne w treatments and targets for therapy, and role of WAP domain-containing proteins . (PubMed id 21936828)1 Galustian C....Smith R.A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58189 HGNC: 15466 AceView: WFDC1 Ensembl:ENSG00000103175 euGenes: HUgn58189
    ECgene: WFDC1 H-InvDB: WFDC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WFDC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WFDC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WFDC1 gene:
    Search GeneIP for patents involving WFDC1

    GeneCards and IP:
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