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Aliases for WFDC1 Gene

Aliases for WFDC1 Gene

  • WAP Four-Disulfide Core Domain 1 2 3 5
  • Prostate Stromal Protein Ps20 3 4
  • Ps20 Growth Inhibitor 3 4
  • PS20 3 4
  • WAP Four-Disulfide Core Domain 1 Homolog 3
  • WAP Four-Disulfide Core Domain Protein 1 3

External Ids for WFDC1 Gene

Previous GeneCards Identifiers for WFDC1 Gene

  • GC16P075178
  • GC16P085295
  • GC16P084067
  • GC16P084108
  • GC16P082885
  • GC16P070082

Summaries for WFDC1 Gene

Entrez Gene Summary for WFDC1 Gene

  • This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for WFDC1 Gene

WFDC1 (WAP Four-Disulfide Core Domain 1) is a Protein Coding gene. Diseases associated with WFDC1 include Corneal Staphyloma and Hypochondriasis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.

UniProtKB/Swiss-Prot for WFDC1 Gene

  • Has growth inhibitory activity.

Gene Wiki entry for WFDC1 Gene

Additional gene information for WFDC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC1 Gene

Genomics for WFDC1 Gene

GeneHancer (GH) Regulatory Elements for WFDC1 Gene

Promoters and enhancers for WFDC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I084294 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.1 1089 3.2 PKNOX1 ZNF316 POLR2A ZFP36 MNT MAFK NR2F2 ENSG00000260530 WFDC1 LOC105376777
GH16I084266 Enhancer 0.9 ENCODE 12.5 -28.1 -28066 0.2 PKNOX1 ATF1 MLX ARID4B ZNF76 FEZF1 ETS1 ZNF143 FOS CREM WFDC1 KCNG4 NECAB2 RNA5SP433 GC16M084262 LOC105376777
GH16I085219 Enhancer 1.3 Ensembl ENCODE dbSUPER 5.5 +926.6 926621 3.2 PKNOX1 ZSCAN4 MZF1 FEZF1 ZNF48 RAD21 YY1 ZNF335 ZNF121 GLIS2 WFDC1 PIR44306 GSE1 COX6CP16
GH16I084443 Enhancer 0.6 ENCODE 10.4 +148.8 148824 0.9 ELF3 GATAD2A SAP130 ZNF644 RAD21 RARA GABPA KLF16 ETV4 HNF4A WFDC1 ATP2C2-AS1 GC16P084460 ATP2C2
GH16I084300 Enhancer 0.8 Ensembl ENCODE dbSUPER 7 +8.5 8453 4.2 FOXA2 NR2F2 WFDC1 ENSG00000260530 ENSG00000260504
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WFDC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WFDC1 gene promoter:

Genomic Locations for WFDC1 Gene

Genomic Locations for WFDC1 Gene
chr16:84,294,646-84,329,851
(GRCh38/hg38)
Size:
35,206 bases
Orientation:
Plus strand
chr16:84,328,252-84,363,450
(GRCh37/hg19)

Genomic View for WFDC1 Gene

Genes around WFDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC1 Gene

Proteins for WFDC1 Gene

  • Protein details for WFDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC57-WFDC1_HUMAN
    Recommended name:
    WAP four-disulfide core domain protein 1
    Protein Accession:
    Q9HC57
    Secondary Accessions:
    • D3DUL7
    • Q8NC27
    • Q9HAU1

    Protein attributes for WFDC1 Gene

    Size:
    220 amino acids
    Molecular mass:
    23977 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG15263.1; Type=Frameshift; Positions=166, 173; Evidence={ECO:0000305};

neXtProt entry for WFDC1 Gene

Post-translational modifications for WFDC1 Gene

No Post-translational modifications

Other Protein References for WFDC1 Gene

No data available for DME Specific Peptides for WFDC1 Gene

Domains & Families for WFDC1 Gene

Gene Families for WFDC1 Gene

Protein Domains for WFDC1 Gene

Suggested Antigen Peptide Sequences for WFDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WFDC1: view

No data available for UniProtKB/Swiss-Prot for WFDC1 Gene

Function for WFDC1 Gene

Molecular function for WFDC1 Gene

UniProtKB/Swiss-Prot Function:
Has growth inhibitory activity.

Phenotypes From GWAS Catalog for WFDC1 Gene

Gene Ontology (GO) - Molecular Function for WFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFDC1: view
genes like me logo Genes that share phenotypes with WFDC1: view

Animal Models for WFDC1 Gene

MGI Knock Outs for WFDC1:

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC1 Gene

Localization for WFDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for WFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,NAS 10967136
genes like me logo Genes that share ontologies with WFDC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WFDC1 Gene

Pathways & Interactions for WFDC1 Gene

SuperPathways for WFDC1 Gene

No Data Available

Interacting Proteins for WFDC1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000219454%0d%0a9606.ENSP00000358309%0d%0a9606.ENSP00000363763%0d%0a9606.ENSP00000351209%0d%0a9606.ENSP00000273854%0d%0a9606.ENSP00000381097%0d%0a
Selected Interacting proteins: Q9HC57-WFDC1_HUMAN ENSP00000219454 for WFDC1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for WFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IBA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0030308 negative regulation of cell growth NAS 10967136
GO:0032355 response to estradiol IEA --
genes like me logo Genes that share ontologies with WFDC1: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC1 Gene

Drugs & Compounds for WFDC1 Gene

No Compound Related Data Available

Transcripts for WFDC1 Gene

Unigene Clusters for WFDC1 Gene

WAP four-disulfide core domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:
SP3:

Relevant External Links for WFDC1 Gene

GeneLoc Exon Structure for
WFDC1
ECgene alternative splicing isoforms for
WFDC1

Expression for WFDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WFDC1 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC1 Gene

This gene is overexpressed in Artery - Coronary (x5.8), Artery - Tibial (x5.4), and Prostate (x4.8).

Protein differential expression in normal tissues from HIPED for WFDC1 Gene

This gene is overexpressed in Heart (43.0) and Peripheral blood mononuclear cells (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WFDC1 Gene



Protein tissue co-expression partners for WFDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of WFDC1 Gene:

WFDC1

SOURCE GeneReport for Unigene cluster for WFDC1 Gene:

Hs.36688

Evidence on tissue expression from TISSUES for WFDC1 Gene

  • Intestine(4.2)
  • Kidney(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with WFDC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WFDC1 Gene

Orthologs for WFDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WFDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WFDC1 33 34
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia WFDC1 33 34
  • 86.79 (n)
cow
(Bos Taurus)
Mammalia WFDC1 33
  • 83.72 (n)
mouse
(Mus musculus)
Mammalia Wfdc1 33 16 34
  • 79.59 (n)
oppossum
(Monodelphis domestica)
Mammalia WFDC1 34
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wfdc1 33
  • 78.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WFDC1 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves WFDC1 34
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WFDC1 34
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wfdc1 34
  • 55 (a)
OneToOne
Species where no ortholog for WFDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WFDC1 Gene

ENSEMBL:
Gene Tree for WFDC1 (if available)
TreeFam:
Gene Tree for WFDC1 (if available)

Paralogs for WFDC1 Gene

No data available for Paralogs for WFDC1 Gene

Variants for WFDC1 Gene

Sequence variations from dbSNP and Humsavar for WFDC1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs11643870 A breast cancer sample 84,318,346(+) G/A coding_sequence_variant, intron_variant, missense_variant
rs1000024918 -- 84,324,852(+) C/G intron_variant
rs1000077505 -- 84,324,990(+) T/G intron_variant
rs1000102476 -- 84,299,093(+) G/T intron_variant
rs1000148462 -- 84,310,005(+) TTTTT/TTTTTT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC1 Gene

Variant ID Type Subtype PubMed ID
dgv1372n106 CNV deletion 24896259
dgv547e214 CNV loss 21293372
dgv548e214 CNV gain 21293372
esv2714827 CNV deletion 23290073
esv2761930 CNV gain 21179565
esv3639414 CNV loss 21293372
nsv483044 CNV gain 15286789
nsv523416 CNV loss 19592680
nsv573425 CNV loss 21841781
nsv833310 CNV loss 17160897

Variation tolerance for WFDC1 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WFDC1 Gene

Human Gene Mutation Database (HGMD)
WFDC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WFDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC1 Gene

Disorders for WFDC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WFDC1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
corneal staphyloma
hypochondriasis
  • hypochondria
- elite association - COSMIC cancer census association via MalaCards
Search WFDC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WFDC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WFDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WFDC1 Gene

Publications for WFDC1 Gene

  1. The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers. (PMID: 10967136) Larsen M … Rowley DR (Mammalian genome : official journal of the International Mammalian Genome Society 2000) 2 3 4 22 58
  2. The WFDC1 gene: role in wound response and tissue homoeostasis. (PMID: 21936833) Ressler SJ … Rowley DR (Biochemical Society transactions 2011) 2 3 58
  3. Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis. (PMID: 20090771) Briggs FB … Barcellos LF (Genes and immunity 2010) 3 44 58
  4. Modulated expression of WFDC1 during carcinogenesis and cellular senescence. (PMID: 18842679) Madar S … Rotter V (Carcinogenesis 2009) 3 22 58
  5. WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection. (PMID: 17942534) Alvarez R … Vyakarnam A (Journal of virology 2008) 3 22 58

Products for WFDC1 Gene

Sources for WFDC1 Gene

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