Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WFDC1 Gene

protein-coding GIFtS: 49
GCID: GC16P084328

WAP four-disulfide core domain 1

Explore 13 diseases affiliated with
WFDC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
WAP Four-Disulfide Core Domain 1¹ ²
PS20¹ ² ³ ⁵
Prostate Stromal Protein Ps20² ³
Ps20 Growth Inhibitor² ³
WAP Four-Disulfide Core Domain 1 Homolog²
WAP Four-Disulfide Core Domain Protein 1²

External Ids:	HGNC: 15466¹	Entrez Gene: 58189²	Ensembl: ENSG00000103175⁷	OMIM: 605322⁵	UniProtKB: Q9HC57³

Export aliases for WFDC1 gene to outside databases

Previous GC identifers: GC16P075178 GC16P085295 GC16P084067 GC16P084108 GC16P082885 GC16P070082

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WFDC1:

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain,

or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and

functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the

rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome

16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers

and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is

suggested to be a tumor suppressor gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WFDC1_HUMAN, Q9HC57

Function: Has growth inhibitory activity (By similarity)

Gene Wiki entry for WFDC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WFDC1 gene promoter:
NF-1 Pbx1a MyoD HSF1 (long) C/EBPalpha PPAR-gamma1 HSF2 HSF1short PPAR-gamma2 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WFDC1 promoter sequence

Search SABiosciences Chromatin IP Primers for WFDC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3 Ensembl cytogenetic band: 16q24.1 HGNC cytogenetic band: 16q24.1

WFDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WFDC1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P084328: view genomic region (about GC identifiers)

Start:	84,328,252 bp from pter	End:	84,363,450 bp from pter
Size:	35,199 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WFDC1_HUMAN, Q9HC57 (See protein sequence)

Recommended Name: WAP four-disulfide core domain protein 1 precursor

Size: 220 amino acids; 23977 Da

Subcellular location: Secreted (Potential)

Sequence caution: Sequence=AAG15263.1; Type=Frameshift; Positions=166, 173;

Secondary accessions: D3DUL7 Q8NC27 Q9HAU1

Explore the universe of human proteins at neXtProt for WFDC1: NX_Q9HC57

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HC57

WFDC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_067020.2

ENSEMBL proteins:

ENSP00000219454 ENSP00000456920

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: WFDC1 OriGene Custom Protein Services for WFDC1
	GenScript Custom Purified and Recombinant Proteins Services for WFDC1
	Novus Biologicals WFDC1 Protein Novus Biologicals WFDC1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for WFDC1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	NAS	10967136

WFDC1 for ontologies About GeneDecksing

WFDC1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: WFDC1 OriGene Custom Antibody Services for WFDC1
	GenScript Custom Superior Antibodies Services for WFDC1
	Novus Biologicals WFDC1 Antibodies
	Search for Antibodies for WFDC1 at Abcam
	Uscn Antibodies for WFDC1
	Search ThermoFisher Antibodies for WFDC1

Assay Products for WFDC1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for WFDC1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for WFDC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WFDC1 for domains About GeneDecksing

1 InterPro domain/family:

IPR008197 Whey_acidic_protein_4-diS_core

Graphical View of Domain Structure for InterPro Entry Q9HC57

ProtoNet protein and cluster: Q9HC57

1 Blocks protein family: IPB008197 4-disulphide core signature

UniProtKB/Swiss-Prot: WFDC1_HUMAN, Q9HC57

Similarity: Contains 1 WAP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: WFDC1_HUMAN, Q9HC57

Function: Has growth inhibitory activity (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: WFDC1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WFDC1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate WFDC1
		SwitchGear 3'UTR luciferase reporter plasmid: WFDC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WFDC1 (see all 7) OriGene shRNA RFP: WFDC1 OriGene siRNA: WFDC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WFDC1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for WFDC1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: WFDC1 (NM_021197)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WFDC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for WFDC1
		Search LifeMap BioReagents cell lines for WFDC1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	--

WFDC1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for WFDC1:

Decreased nuclei size in G2M

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for WFDC1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for WFDC1 (ENSP00000219454⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EZR	ENSP00000338934⁴	STRING: ENSP00000338934
FOSL1	ENSP00000310170⁴	STRING: ENSP00000310170
RAB40B	ENSP00000269347⁴	STRING: ENSP00000269347
XRCC2	ENSP00000352271⁴	STRING: ENSP00000352271
ZNF677	ENSP00000334394⁴	STRING: ENSP00000334394

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	--	--
GO:0030308	negative regulation of cell growth	NAS	10967136
GO:0032355	response to estradiol stimulus	IEA	--
GO:0042493	response to drug	IEA	--
GO:0050680	negative regulation of epithelial cell proliferation	IEA	--

WFDC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WFDC1
Search CenterWatch for drugs/clinical trials and news about WFDC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WFDC1 gene:

NM_021197.2

Unigene Cluster for WFDC1:

WAP four-disulfide core domain 1

Hs.36688 [show with all ESTs]

Unigene Representative Sequence: AK128711

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000219454(uc002fhv.3 uc002fhw.3) ENST00000568638 ENST00000567056

ENST00000564658

miRNA Products:		OriGene 3'-UTR Clone: WFDC1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WFDC1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate WFDC1
		SwitchGear 3'UTR luciferase reporter plasmid: WFDC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WFDC1 (see all 7) OriGene shRNA RFP: WFDC1 OriGene siRNA: WFDC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WFDC1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: WFDC1 (NM_021197)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WFDC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat WFDC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC1

Additional cDNA sequence:

AF169631.1 AF302109.1 AK075061.1 AK128711.1 AL713785.1 BC029159.1

4 DOTS entries:

DT.212641 DT.100777273 DT.101962741 DT.120691337

24/110 AceView cDNA sequences (see all 110):

BF447098 AI360465 W25322 CR615719 BQ678502 AL545137 BM663231 AI289243

BF725477 AI742302 AI224935 CR604862 AI142995 CR595501 AW052100 AI925090

CR608359 BF449060 CR610530 AI190199 AI246305 BQ670532 AI568809 AI199143

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for WFDC1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b
SP1:
SP2:
SP3:

ECgene alternative splicing isoforms for WFDC1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WFDC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGCATTTC

About this image

WFDC1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Extraembryonic endoderm-like cells (Generation of extrae...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See WFDC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WFDC1

SOURCE GeneReport for Unigene cluster: Hs.36688

SABiosciences Custom PCR Arrays for WFDC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat WFDC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for WFDC1 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Wfdc1^{1 , 5}	WAP four-disulfide core domain 1^{1, 5}	79.59(n)¹ 83.73(a)¹		8 (68.15 cM)⁵ 67866¹ NM_023395.2¹ NP_075884.1¹ 119666365⁵
chicken (Gallus gallus)	Aves	WFDC1¹	WAP four-disulfide core domain 1	67.15(n) 65.38(a)		395238 NM_204554.1 NP_989885.1
lizard (Anolis carolinensis)	Reptilia	WFDC1⁶	--	57(a)	1 ↔ 1	GL343849.1(68594-75410)
zebrafish (Danio rerio)	Actinopterygii	wfdc1¹	WAP four-disulfide core domain 1	62.94(n) 62.44(a)		560860 NM_001100000.1 NP_001093470.1

ENSEMBL Gene Tree for WFDC1 (if available)
TreeFam Gene Tree for WFDC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189602789^1,2		--	84326435(+)	`TCTCAC/TGCTTG`	1	--	us2k¹		0	--	--	--	--
rs182125700^1,2		--	84326436(+)	`CTCACG/TCTTGG`	1	--	us2k¹		0	--	--	--	--
rs75501584^1,2	C,F,	--	84326459(+)	`ACAGGA/TCTCTG`	1	--	us2k¹		1		NA	120
rs186728955^1,2		--	84326543(+)	`ACCTGC/TTTATA`	1	--	us2k¹		0	--	--	--	--
rs200876251^1,2		--	84326629(+)	`TTTAA-/GGGTTT`	1	--	us2k¹		0	--	--	--	--
rs56215460^1,2	C	--	84326632(+)	`TTTTTT/-GATAC`	1	--	us2k¹		1		NA	2
rs200852204^1,2	C	--	84326644(+)	`TTTTTG/TATACA`	1	--	us2k¹		0	--	--	--	--
rs191170418^1,2		--	84326651(+)	`TACAGA/GGTCTT`	1	--	us2k¹		0	--	--	--	--
rs183698959^1,2		--	84326652(+)	`ACAGGC/GTCTTG`	1	--	us2k¹		0	--	--	--	--
rs889734^1,2	C,F,	--	84326666(-)	`cctggG/Ttcaca`	1	--	us2k¹		4		NA	126

HapMap Linkage Disequilibrium report for WFDC1 (84328252 - 84363450 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WFDC1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC1

DNA2.0 Custom Variant and Variant Library Synthesis for WFDC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WFDC1 for disorders           About GeneDecksing

OMIM gene information: 605322    OMIM disorders: --

13 diseases for WFDC1:    About MalaCards

prostatitis hepatocellular cancer wilms tumor rheumatoid arthritis

hepatocellular carcinoma arthritis retinoblastoma breast carcinoma

prostate cancer carcinoma immunodeficiency melanoma

hiv type 1

1 Novoseek disease relationship for WFDC1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	11	10	14522910 (3), 18842679 (2), 17210724 (1)

Human Genome Epidemiology (HuGE) Navigator: WFDC1 (2 documents)

Export disorders for WFDC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WFDC1 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with WFDC1)

Utopia: connect your pdf to the dynamic
world of online information

The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers. (PubMed id 10967136)^{1, 2, 3, 9} Larsen M....Rowley D.R. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. (PubMed id 14522910)^{1, 9} McAlhany S.J....Rowley D.R. (2003)
WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection. (PubMed id 17942534)^{1, 9} Alvarez R....Vyakarnam A. (2008)
Modulated expression of WFDC1 during carcinogenesis and cellular senescence. (PubMed id 18842679)^{1, 9} Madar S....Rotter V. (2008)
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)¹ Fox C.S....Borecki I.B. (2012)
WFDC1 expression identifies memory CD4 T-lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhe sive junctions. (PubMed id 21545747)¹ Alvarez R.A....Vyakarnam A. (2011)
Supervised machine learning and logistic regression i dentifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis. (PubMed id 20090771)¹ Briggs F.B....Barcellos L.F. (2010)
Expression and functional analysis of the WAP four di sulfide core domain 1 gene in human melanoma. (PubMed id 19488830)¹ Liu S....Riker A.I. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 58189	HGNC: 15466	AceView: WFDC1	Ensembl:ENSG00000103175	euGenes: HUgn58189
ECgene: WFDC1	H-InvDB: WFDC1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WFDC1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WFDC1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for WFDC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WFDC1 gene:
Search GeneIP for patents involving WFDC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for WFDC1		OriGene shRNA RFP for WFDC1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WFDC1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WFDC1
	OriGene Protein Over-expression Lysate for WFDC1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for WFDC1		OriGene 3'-UTR Clone for WFDC1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WFDC1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for WFDC1		OriGene Custom Protein Services for WFDC1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WFDC1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WFDC1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WFDC1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WFDC1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WFDC1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WFDC1

	GenScript Custom Purified and Recombinant Proteins Services for WFDC1		GenScript cDNA clones with any tag delivered in your preferred vector for WFDC1
	GenScript Custom Assay Services for WFDC1		GenScript Custom Superior Antibodies Services for WFDC1
	GenScript Custom overexpressing Cell Line Services for WFDC1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in WFDC1 promoter
	Search Chromatin IP Primers for WFDC1
	RT² qPCR Primer Assay in human, mouse, rat WFDC1
	Search GNC Networks for WFDC1
	SABiosciences Custom PCR Arrays for WFDC1

Search Tocris compounds for WFDC1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	WFDC1 antibodies
	WFDC1 proteins
	WFDC1 lysates

	Search for Antibodies for WFDC1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for WFDC1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

WFDC1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for WFDC1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WFDC1

	SwitchGear 3'UTR luciferase reporter plasmids for WFDC1
	SwitchGear Promoter luciferase reporter plasmids for WFDC1

Search ThermoFisher Antibodies for WFDC1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WFDC1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes WFDC1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

WFDC1 Gene

WAP four-disulfide core domain 1

Aliases
for WFDC1 gene

Summaries
for WFDC1 gene

Genomic Views
for WFDC1 gene

Proteins
for WFDC1 gene

Protein Domains /
Families
for WFDC1 gene

Function
for WFDC1 gene

Pathways & Interactions
for WFDC1 gene

Drugs & Compounds
for WFDC1 gene

Transcripts
for WFDC1 gene

Expression
for WFDC1 gene

Orthologs
for WFDC1 gene

Paralogs
for WFDC1 gene

Genomic Variants
for WFDC1 gene

Disorders / Diseases
for WFDC1 gene

Publications
for WFDC1 gene

External Searches for WFDC1 gene

Genome Databases showing WFDC1 gene

Other Databases showing WFDC1 gene

Specialized Databases showing WFDC1 gene

Intellectual Property
for WFDC1 gene

Products
for WFDC1 gene

View Random Gene

Advanced Search

Export list of displayed genes

WFDC1 Gene

WAP four-disulfide core domain 1

Aliasesfor WFDC1 gene

Summariesfor WFDC1 gene

Genomic Viewsfor WFDC1 gene

Proteinsfor WFDC1 gene

Protein Domains /Familiesfor WFDC1 gene

Functionfor WFDC1 gene

Pathways & Interactionsfor WFDC1 gene

Drugs & Compoundsfor WFDC1 gene

Transcriptsfor WFDC1 gene

Expression for WFDC1 gene

Orthologsfor WFDC1 gene

Paralogsfor WFDC1 gene

Genomic Variantsfor WFDC1 gene

Disorders / Diseasesfor WFDC1 gene

Publicationsfor WFDC1 gene

External Searches for WFDC1 gene

Genome Databases showing WFDC1 gene

Other Databases showing WFDC1 gene

Specialized Databases showing WFDC1 gene

Intellectual Propertyfor WFDC1 gene

Productsfor WFDC1 gene

View Random Gene

Aliases
for WFDC1 gene

Summaries
for WFDC1 gene

Genomic Views
for WFDC1 gene

Proteins
for WFDC1 gene

Protein Domains /
Families
for WFDC1 gene

Function
for WFDC1 gene

Pathways & Interactions
for WFDC1 gene

Drugs & Compounds
for WFDC1 gene

Transcripts
for WFDC1 gene

Expression
for WFDC1 gene

Orthologs
for WFDC1 gene

Paralogs
for WFDC1 gene

Genomic Variants
for WFDC1 gene

Disorders / Diseases
for WFDC1 gene

Publications
for WFDC1 gene

Intellectual Property
for WFDC1 gene

Products
for WFDC1 gene