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Aliases for WFDC1 Gene

Aliases for WFDC1 Gene

  • WAP Four-Disulfide Core Domain 1 2 3
  • PS20 3 4 6
  • Prostate Stromal Protein Ps20 3 4
  • Ps20 Growth Inhibitor 3 4
  • WAP Four-Disulfide Core Domain 1 Homolog 3
  • WAP Four-Disulfide Core Domain Protein 1 3

External Ids for WFDC1 Gene

Previous GeneCards Identifiers for WFDC1 Gene

  • GC16P075178
  • GC16P085295
  • GC16P084067
  • GC16P084108
  • GC16P082885
  • GC16P070082

Summaries for WFDC1 Gene

Entrez Gene Summary for WFDC1 Gene

  • This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for WFDC1 Gene

WFDC1 (WAP Four-Disulfide Core Domain 1) is a Protein Coding gene. Diseases associated with WFDC1 include wilms tumor. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for WFDC1 Gene

  • Has growth inhibitory activity.

Gene Wiki entry for WFDC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC1 Gene

Genomics for WFDC1 Gene

Regulatory Elements for WFDC1 Gene

Genomic Location for WFDC1 Gene

Start:
84,294,645 bp from pter
End:
84,329,851 bp from pter
Size:
35,207 bases
Orientation:
Plus strand

Genomic View for WFDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WFDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC1 Gene

Proteins for WFDC1 Gene

  • Protein details for WFDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC57-WFDC1_HUMAN
    Recommended name:
    WAP four-disulfide core domain protein 1
    Protein Accession:
    Q9HC57
    Secondary Accessions:
    • D3DUL7
    • Q8NC27
    • Q9HAU1

    Protein attributes for WFDC1 Gene

    Size:
    220 amino acids
    Molecular mass:
    23977 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG15263.1; Type=Frameshift; Positions=166, 173; Evidence={ECO:0000305};

neXtProt entry for WFDC1 Gene

Proteomics data for WFDC1 Gene at MOPED

Post-translational modifications for WFDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WFDC1 Gene

No data available for DME Specific Peptides for WFDC1 Gene

Domains for WFDC1 Gene

Gene Families for WFDC1 Gene

HGNC:
  • WFDC :WAP four-disulfide core domain containing

Protein Domains for WFDC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for WFDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HC57

UniProtKB/Swiss-Prot:

WFDC1_HUMAN :
  • Q9HC57
Domain:
  • Contains 1 WAP domain.
genes like me logo Genes that share domains with WFDC1: view

Function for WFDC1 Gene

Molecular function for WFDC1 Gene

UniProtKB/Swiss-Prot Function: Has growth inhibitory activity.

Gene Ontology (GO) - Molecular Function for WFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity --
genes like me logo Genes that share ontologies with WFDC1: view

Phenotypes for WFDC1 Gene

GenomeRNAi human phenotypes for WFDC1:
genes like me logo Genes that share phenotypes with WFDC1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WFDC1 Gene

Localization for WFDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WFDC1 Gene COMPARTMENTS Subcellular localization image for WFDC1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space NAS 10967136
genes like me logo Genes that share ontologies with WFDC1: view

Pathways for WFDC1 Gene

SuperPathways for WFDC1 Gene

No Data Available

Interacting Proteins for WFDC1 Gene

Gene Ontology (GO) - Biological Process for WFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0030308 negative regulation of cell growth NAS 10967136
GO:0032355 response to estradiol IEA --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with WFDC1: view

No data available for Pathways by source for WFDC1 Gene

Transcripts for WFDC1 Gene

Unigene Clusters for WFDC1 Gene

WAP four-disulfide core domain 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WFDC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:
SP3:

Relevant External Links for WFDC1 Gene

GeneLoc Exon Structure for
WFDC1
ECgene alternative splicing isoforms for
WFDC1

Expression for WFDC1 Gene

mRNA expression in normal human tissues for WFDC1 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC1 Gene

This gene is overexpressed in Artery - Coronary (5.8), Artery - Tibial (5.4), and Prostate (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WFDC1 Gene

SOURCE GeneReport for Unigene cluster for WFDC1 Gene Hs.36688

genes like me logo Genes that share expressions with WFDC1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WFDC1 Gene

Orthologs for WFDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WFDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WFDC1 35
  • 99.24 (n)
  • 99.09 (a)
WFDC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WFDC1 35
  • 83.72 (n)
  • 83.87 (a)
dog
(Canis familiaris)
Mammalia WFDC1 35
  • 86.79 (n)
  • 89.4 (a)
WFDC1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wfdc1 35
  • 79.59 (n)
  • 83.73 (a)
Wfdc1 16
Wfdc1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WFDC1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WFDC1 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wfdc1 35
  • 78.41 (n)
  • 81.9 (a)
chicken
(Gallus gallus)
Aves WFDC1 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WFDC1 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wfdc1 36
  • 55 (a)
OneToOne
Species with no ortholog for WFDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WFDC1 Gene

ENSEMBL:
Gene Tree for WFDC1 (if available)
TreeFam:
Gene Tree for WFDC1 (if available)

Paralogs for WFDC1 Gene

No data available for Paralogs for WFDC1 Gene

Variants for WFDC1 Gene

Sequence variations from dbSNP and Humsavar for WFDC1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4557 -- 84,329,589(-) ATGGG(C/G/T)GGCGG utr-variant-3-prime
rs9910 -- 84,329,720(+) CATCC(A/T)TCAGG utr-variant-3-prime
rs173429 -- 84,324,739(+) AAACA(C/T)GCCTG intron-variant
rs181740 -- 84,314,288(+) AAGTG(C/G)GGAGT intron-variant
rs184955 -- 84,301,983(+) CAGAT(G/T)GATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC1 Gene

Variant ID Type Subtype PubMed ID
nsv833310 CNV Loss 17160897
nsv907065 CNV Gain 21882294
nsv907066 CNV Gain 21882294
esv2714827 CNV Deletion 23290073
nsv523416 CNV Loss 19592680

Relevant External Links for WFDC1 Gene

HapMap Linkage Disequilibrium report
WFDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC1 Gene

Disorders for WFDC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for WFDC1 Gene including...

Search for WFDC1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for WFDC1 Gene

Disease -log(P) Hits PubMed IDs
tumors 11 6

Relevant External Links for WFDC1

Genetic Association Database (GAD)
WFDC1
Human Genome Epidemiology (HuGE) Navigator
WFDC1
genes like me logo Genes that share disorders with WFDC1: view

No data available for UniProtKB/Swiss-Prot for WFDC1 Gene

Publications for WFDC1 Gene

  1. The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers. (PMID: 10967136) Larsen M. … Rowley D.R. (Mamm. Genome 2000) 2 3 4 23
  2. Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. (PMID: 14522910) McAlhany S.J. … Rowley D.R. (Cancer Res. 2003) 3 23
  3. WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection. (PMID: 17942534) Alvarez R. … Vyakarnam A. (J. Virol. 2008) 3 23
  4. Modulated expression of WFDC1 during carcinogenesis and cellular senescence. (PMID: 18842679) Madar S. … Rotter V. (Carcinogenesis 2009) 3 23
  5. Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis. (PMID: 20090771) Briggs F.B. … Barcellos L.F. (Genes Immun. 2010) 3 48

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