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Aliases for WFDC1 Gene

Aliases for WFDC1 Gene

  • WAP Four-Disulfide Core Domain 1 2 3 5
  • Prostate Stromal Protein Ps20 3 4
  • Ps20 Growth Inhibitor 3 4
  • PS20 3 4
  • WAP Four-Disulfide Core Domain 1 Homolog 3
  • WAP Four-Disulfide Core Domain Protein 1 3

External Ids for WFDC1 Gene

Previous GeneCards Identifiers for WFDC1 Gene

  • GC16P075178
  • GC16P085295
  • GC16P084067
  • GC16P084108
  • GC16P082885
  • GC16P070082

Summaries for WFDC1 Gene

Entrez Gene Summary for WFDC1 Gene

  • This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for WFDC1 Gene

WFDC1 (WAP Four-Disulfide Core Domain 1) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.

UniProtKB/Swiss-Prot for WFDC1 Gene

  • Has growth inhibitory activity.

Gene Wiki entry for WFDC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WFDC1 Gene

Genomics for WFDC1 Gene

Regulatory Elements for WFDC1 Gene

Enhancers for WFDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F084266 0.9 ENCODE 12.5 -28.1 -28067 0.2 ATF1 CBX3 CREB3L1 MLX ZNF76 ARID4B FEZF1 ETS1 ZNF143 FOS WFDC1 KCNG4 CRISPLD2 NECAB2 ENSG00000261243 GC16M084262 RNA5SP433 LOC105376777
GH16F084443 0.7 ENCODE 10.4 +148.8 148824 0.9 GATAD2A ELF3 SAP130 RAD21 ZNF644 HBP1 RARA KLF16 GABPB1 ETV4 WFDC1 LOC105371374 GC16P084460 ATP2C2
GH16F085219 1.2 Ensembl ENCODE 5.5 +926.6 926586 3.3 PKNOX1 SIN3A FEZF1 ZNF2 ZNF48 YY1 ZNF121 GLIS2 ZNF143 ZNF263 WFDC1 PIR44306 COX6CP16
GH16F084300 0.7 Ensembl ENCODE 7 +8.5 8453 4.2 TAL1 NR2F2 WFDC1 ENSG00000260530 ENSG00000260504
GH16F084294 0.9 Ensembl ENCODE 0.8 +1.1 1090 3.2 PKNOX1 MNT ZIC2 NR2F2 ZNF664 ZNF316 POLR2A GLIS1 NFE2 MAFK ENSG00000260530 WFDC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WFDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for WFDC1 Gene

Chromosome:
16
Start:
84,294,646 bp from pter
End:
84,329,851 bp from pter
Size:
35,206 bases
Orientation:
Plus strand

Genomic View for WFDC1 Gene

Genes around WFDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WFDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WFDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WFDC1 Gene

Proteins for WFDC1 Gene

  • Protein details for WFDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC57-WFDC1_HUMAN
    Recommended name:
    WAP four-disulfide core domain protein 1
    Protein Accession:
    Q9HC57
    Secondary Accessions:
    • D3DUL7
    • Q8NC27
    • Q9HAU1

    Protein attributes for WFDC1 Gene

    Size:
    220 amino acids
    Molecular mass:
    23977 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG15263.1; Type=Frameshift; Positions=166, 173; Evidence={ECO:0000305};

neXtProt entry for WFDC1 Gene

Post-translational modifications for WFDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WFDC1 Gene

No data available for DME Specific Peptides for WFDC1 Gene

Domains & Families for WFDC1 Gene

Gene Families for WFDC1 Gene

Protein Domains for WFDC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for WFDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HC57

UniProtKB/Swiss-Prot:

WFDC1_HUMAN :
  • Contains 1 WAP domain.
Domain:
  • Contains 1 WAP domain.
genes like me logo Genes that share domains with WFDC1: view

Function for WFDC1 Gene

Molecular function for WFDC1 Gene

UniProtKB/Swiss-Prot Function:
Has growth inhibitory activity.

Gene Ontology (GO) - Molecular Function for WFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with WFDC1: view
genes like me logo Genes that share phenotypes with WFDC1: view

Animal Models for WFDC1 Gene

MGI Knock Outs for WFDC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for WFDC1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for WFDC1 Gene

Localization for WFDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WFDC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WFDC1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for WFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space NAS 10967136
genes like me logo Genes that share ontologies with WFDC1: view

Pathways & Interactions for WFDC1 Gene

SuperPathways for WFDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IBA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0030308 negative regulation of cell growth NAS 10967136
GO:0032355 response to estradiol IEA --
genes like me logo Genes that share ontologies with WFDC1: view

No data available for Pathways by source and SIGNOR curated interactions for WFDC1 Gene

Transcripts for WFDC1 Gene

Unigene Clusters for WFDC1 Gene

WAP four-disulfide core domain 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WFDC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:
SP3:

Relevant External Links for WFDC1 Gene

GeneLoc Exon Structure for
WFDC1
ECgene alternative splicing isoforms for
WFDC1

Expression for WFDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WFDC1 Gene

mRNA differential expression in normal tissues according to GTEx for WFDC1 Gene

This gene is overexpressed in Artery - Coronary (x5.8), Artery - Tibial (x5.4), and Prostate (x4.8).

Protein differential expression in normal tissues from HIPED for WFDC1 Gene

This gene is overexpressed in Heart (43.0) and Peripheral blood mononuclear cells (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WFDC1 Gene



Protein tissue co-expression partners for WFDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of WFDC1 Gene:

WFDC1

SOURCE GeneReport for Unigene cluster for WFDC1 Gene:

Hs.36688
genes like me logo Genes that share expression patterns with WFDC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WFDC1 Gene

Orthologs for WFDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WFDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WFDC1 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia WFDC1 34 35
  • 86.79 (n)
cow
(Bos Taurus)
Mammalia WFDC1 34
  • 83.72 (n)
mouse
(Mus musculus)
Mammalia Wfdc1 34 16 35
  • 79.59 (n)
oppossum
(Monodelphis domestica)
Mammalia WFDC1 35
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wfdc1 34
  • 78.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WFDC1 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves WFDC1 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WFDC1 35
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wfdc1 35
  • 55 (a)
OneToOne
Species where no ortholog for WFDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WFDC1 Gene

ENSEMBL:
Gene Tree for WFDC1 (if available)
TreeFam:
Gene Tree for WFDC1 (if available)

Paralogs for WFDC1 Gene

No data available for Paralogs for WFDC1 Gene

Variants for WFDC1 Gene

Sequence variations from dbSNP and Humsavar for WFDC1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11643870 A breast cancer sample 84,318,346(+) AGGAG(A/G)TGTTA intron-variant, reference, missense
rs10438602 -- 84,301,002(+) agaga(C/T)ataga intron-variant
rs10438618 -- 84,300,994(+) aaagg(A/G)gaaga intron-variant
rs10541544 -- 84,309,869(+) GTGCT(-/TGTG)TGTGT intron-variant
rs10687228 -- 84,322,191(+) GTGTG(-/TG/TGTGTGTGTG)AGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WFDC1 Gene

Variant ID Type Subtype PubMed ID
nsv833310 CNV loss 17160897
nsv573425 CNV loss 21841781
nsv523416 CNV loss 19592680
nsv483044 CNV gain 15286789
esv3639414 CNV loss 21293372
esv2761930 CNV gain 21179565
esv2714827 CNV deletion 23290073
dgv548e214 CNV gain 21293372
dgv547e214 CNV loss 21293372
dgv1372n106 CNV deletion 24896259

Variation tolerance for WFDC1 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WFDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WFDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WFDC1 Gene

Disorders for WFDC1 Gene

Relevant External Links for WFDC1

Genetic Association Database (GAD)
WFDC1
Human Genome Epidemiology (HuGE) Navigator
WFDC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WFDC1

No disorders were found for WFDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WFDC1 Gene

Publications for WFDC1 Gene

  1. The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers. (PMID: 10967136) Larsen M. … Rowley D.R. (Mamm. Genome 2000) 2 3 4 22 64
  2. The WFDC1 gene: role in wound response and tissue homoeostasis. (PMID: 21936833) Ressler S.J. … Rowley D.R. (Biochem. Soc. Trans. 2011) 2 3 64
  3. Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis. (PMID: 20090771) Briggs F.B. … Barcellos L.F. (Genes Immun. 2010) 3 46 64
  4. Modulated expression of WFDC1 during carcinogenesis and cellular senescence. (PMID: 18842679) Madar S. … Rotter V. (Carcinogenesis 2009) 3 22 64
  5. WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection. (PMID: 17942534) Alvarez R. … Vyakarnam A. (J. Virol. 2008) 3 22 64

Products for WFDC1 Gene

Sources for WFDC1 Gene

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