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Aliases for WEE2 Gene

Aliases for WEE2 Gene

  • WEE1 Homolog 2 (S. Pombe) 2 3
  • WEE1B 3 4 6
  • Wee1-Like Protein Kinase 1B 3 4
  • Wee1B Kinase 3 4
  • EC 2.7.10.2 4 63
  • Wee1-Like Protein Kinase 2 3
  • EC 2.7.10 63

External Ids for WEE2 Gene

Summaries for WEE2 Gene

GeneCards Summary for WEE2 Gene

WEE2 (WEE1 Homolog 2 (S. Pombe)) is a Protein Coding gene. Diseases associated with WEE2 include western equine encephalitis. Among its related pathways are Cell cycle. GO annotations related to this gene include protein serine/threonine kinase activity and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is PKMYT1.

UniProtKB/Swiss-Prot for WEE2 Gene

  • Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at Tyr-15, leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at Tyr-15, to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WEE2 Gene

Genomics for WEE2 Gene

Genomic Location for WEE2 Gene

Start:
141,708,353 bp from pter
End:
141,731,271 bp from pter
Size:
22,919 bases
Orientation:
Plus strand

Genomic View for WEE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WEE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WEE2 Gene

Regulatory Elements for WEE2 Gene

Proteins for WEE2 Gene

  • Protein details for WEE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C1S8-WEE2_HUMAN
    Recommended name:
    Wee1-like protein kinase 2
    Protein Accession:
    P0C1S8
    Secondary Accessions:

    Protein attributes for WEE2 Gene

    Size:
    567 amino acids
    Molecular mass:
    62925 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WEE2 Gene

Proteomics data for WEE2 Gene at MOPED

Selected DME Specific Peptides for WEE2 Gene

Post-translational modifications for WEE2 Gene

Other Protein References for WEE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for WEE2 Gene

Gene Families for WEE2 Gene

Suggested Antigen Peptide Sequences for WEE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C1S8

UniProtKB/Swiss-Prot:

WEE2_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P0C1S8
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.:
    • P0C1S8
genes like me logo Genes that share domains with WEE2: view

Function for WEE2 Gene

Molecular function for WEE2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at Tyr-15, leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at Tyr-15, to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).

Enzyme Numbers (IUBMB) for WEE2 Gene

Gene Ontology (GO) - Molecular Function for WEE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with WEE2: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WEE2 Gene

Localization for WEE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WEE2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WEE2 Gene COMPARTMENTS Subcellular localization image for WEE2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for WEE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with WEE2: view

Pathways for WEE2 Gene

SuperPathways for WEE2 Gene

Superpath Contained pathways
1 Cell cycle
genes like me logo Genes that share pathways with WEE2: view

Pathways by source for WEE2 Gene

1 KEGG pathway for WEE2 Gene

Gene Ontology (GO) - Biological Process for WEE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007067 mitotic nuclear division IEA --
GO:0007143 female meiotic division ISS --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0035038 female pronucleus assembly ISS --
genes like me logo Genes that share ontologies with WEE2: view

Transcripts for WEE2 Gene

mRNA/cDNA for WEE2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WEE2 Gene

WEE1 homolog 2 (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WEE2 Gene

No ASD Table

Relevant External Links for WEE2 Gene

GeneLoc Exon Structure for
WEE2
ECgene alternative splicing isoforms for
WEE2

Expression for WEE2 Gene

mRNA expression in normal human tissues for WEE2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WEE2 Gene

SOURCE GeneReport for Unigene cluster for WEE2 Gene Hs.657927

mRNA Expression by UniProt/SwissProt for WEE2 Gene

P0C1S8-WEE2_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with WEE2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WEE2 Gene

Orthologs for WEE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WEE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WEE2 35
  • 99.76 (n)
  • 99.65 (a)
WEE2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WEE2 35
  • 80.52 (n)
  • 74.07 (a)
WEE2 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WEE2 35
  • 83.78 (n)
  • 79.22 (a)
WEE2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wee2 35
  • 77.8 (n)
  • 68.98 (a)
Wee2 16
Wee2 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WEE2 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WEE2 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wee2 35
  • 76.82 (n)
  • 68.41 (a)
chicken
(Gallus gallus)
Aves WEE2 35
  • 63.02 (n)
  • 56.83 (a)
WEE2 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WEE2 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wee2 35
  • 56.62 (n)
  • 52.31 (a)
zebrafish
(Danio rerio)
Actinopterygii wee2 35
  • 58.17 (n)
  • 54.55 (a)
wee2 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wee 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWE1 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7177 36
  • 39 (a)
OneToMany
Species with no ortholog for WEE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WEE2 Gene

ENSEMBL:
Gene Tree for WEE2 (if available)
TreeFam:
Gene Tree for WEE2 (if available)

Paralogs for WEE2 Gene

Paralogs for WEE2 Gene

Selected SIMAP similar genes for WEE2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for WEE2 Gene

genes like me logo Genes that share paralogs with WEE2: view

Variants for WEE2 Gene

Sequence variations from dbSNP and Humsavar for WEE2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_041304 -
VAR_041305 A gastric adenocarcinoma sample
VAR_041306 An ovarian mucinous carcinoma sample
VAR_041307 -
VAR_041308 -

Structural Variations from Database of Genomic Variants (DGV) for WEE2 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV Loss 18971310

Relevant External Links for WEE2 Gene

HapMap Linkage Disequilibrium report
WEE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WEE2 Gene

Disorders for WEE2 Gene

(2) University of Copenhagen DISEASES for WEE2 Gene

genes like me logo Genes that share disorders with WEE2: view

No data available for UniProtKB/Swiss-Prot for WEE2 Gene

Publications for WEE2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. (PMID: 11029659) Nakanishi M. … Sasaki M. (Genes Cells 2000) 3 4
  3. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for WEE2 Gene

Sources for WEE2 Gene

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