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WEE2 Gene

protein-coding   GIFtS: 45
GCID: GC07P141409

WEE1 Homolog 2 (S. Pombe)

  See WEE2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WEE1 Homolog 2 (S. Pombe)1 2     EC 2.7.10.23 8
WEE1B2 3 5     Wee1-Like Protein Kinase 22
Wee1-Like Protein Kinase 1B2 3     EC 2.7.108
Wee1B Kinase2 3     

External Ids:    HGNC: 196841   Entrez Gene: 4945512   Ensembl: ENSG000002141027   OMIM: 6140845   UniProtKB: P0C1S83   

Export aliases for WEE2 gene to outside databases

Previous GC identifers: GC07U901539 GC07P141055 GC07P135704


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WEE2 Gene:
WEE2 (WEE1 homolog 2 (S. pombe)) is a protein-coding gene. Diseases associated with WEE2 include western equine encephalitis. GO annotations related to this gene include non-membrane spanning protein tyrosine kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is WEE1.

UniProtKB/Swiss-Prot: WEE2_HUMAN, P0C1S8
Function: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key
regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes
during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating
CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II
exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and
promote pronuclear formation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the WEE2 gene promoter:
         AML1a   GATA-3   Tal-1beta   HNF-1A   PPAR-alpha   POU2F1   POU2F1a   HNF-1   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for WEE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WEE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q32

WEE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WEE2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P141409:  view genomic region     (about GC identifiers)

Start:
141,408,153 bp from pter      End:
141,431,071 bp from pter
Size:
22,919 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,CRA_TCAG 140,745,872-140,768,791      Chr7+,NW_003315922 80,953-103,871     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WEE2_HUMAN, P0C1S8 (See protein sequence)
Recommended Name: Wee1-like protein kinase 2  
Size: 567 amino acids; 62925 Da

Explore the universe of human proteins at neXtProt for WEE2: NX_P0C1S8

Explore proteomics data for WEE2 at MOPED

Post-translational modifications: 

  • Phosphorylation leads to increase its activity (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for WEE2 (P0C1S8)
     WAEDDHM  LGHHPHV  VEEGDSRFLANE 


    See WEE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001099028.1  
    ENSEMBL proteins: 
     ENSP00000380675   ENSP00000420388  

    WEE2 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WEE2

     
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    antibodies-online proteins for WEE2 

     
    antibodies-online peptides for WEE2

    WEE2 Antibody Products:

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    antibodies-online antibodies for WEE2 (20 products) 

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    Cloud-Clone Corp. CLIAs for WEE2
    Search eBioscience for ELISAs for WEE2 
    antibodies-online kits for WEE2 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: WEE1 homolog 2 (S. pombe)
    WEE family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR017164 Wee1-like_protein_kinase

    Graphical View of Domain Structure for InterPro Entry P0C1S8

    ProtoNet protein and cluster: P0C1S8

    UniProtKB/Swiss-Prot: WEE2_HUMAN, P0C1S8
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with WEE2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WEE2_HUMAN, P0C1S8
    Function: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key
    regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes
    during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating
    CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II
    exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and
    promote pronuclear formation (By similarity)
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
         
    Find genes that share ontologies with WEE2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WEE2

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    4 qRT-PCR Assays for microRNAs that regulate WEE2:
    hsa-miR-577 hsa-miR-3163 hsa-miR-548d-3p hsa-miR-551b*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WEE2_HUMAN, P0C1S8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome ----

    Find genes that share ontologies with WEE2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WEE2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59


    Find genes that share SuperPaths with WEE2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for WEE2):
        Cell cycle

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WEE2
    Interactions:

        Search GeneGlobe Interaction Network for WEE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WEE2 (ENSP000003806754) via UniProtKB, MINT, STRING, and/or I2D (see all 152)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF38ENSP000002651544STRING: ENSP00000416125 STRING: ENSP00000265154
    PRMT5ENSP000003191694STRING: ENSP00000319169
    CHEK2ENSP000003720234STRING: ENSP00000372023
    SMPD2ENSP000002580524STRING: ENSP00000258052
    ATRENSP000003437414STRING: ENSP00000343741
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007067mitosis IEA--
    GO:0007143female meiosis ISS--
    GO:0035038female pronucleus assembly ISS--
    GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA--

    Find genes that share ontologies with WEE2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WEE2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WEE2 gene: 
    NM_001105558.1  

    Unigene Cluster for WEE2:

    WEE1 homolog 2 (S. pombe)
    Hs.657927  [show with all ESTs]
    Unigene Representative Sequence: NM_001105558
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397541(uc003vwn.2) ENST00000493845
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate WEE2:
    hsa-miR-577 hsa-miR-3163 hsa-miR-548d-3p hsa-miR-551b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WEE2
      QuantiTect SYBR Green Assays in human, mouse, rat WEE2
      QuantiFast Probe-based Assays in human, mouse, rat WEE2

    Additional mRNA sequence: AK131218.1 

    2 DOTS entries:

    DT.92064000  DT.40111195 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WEE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCAACCTG
    WEE2 Expression
    About this image

    WEE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WEE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657927

    UniProtKB/Swiss-Prot: WEE2_HUMAN, P0C1S8
    Tissue specificity: Expressed in testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WEE2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wee21 , 5 WEE1 homolog 2 (S. pombe)1, 5 77.8(n)1
    68.98(a)1
      6 (18.82 cM)5
    3817591  NM_201370.21  NP_958758.21 
     404428635 
    chicken
    (Gallus gallus)
    Aves WEE21 WEE1 homolog 2 (S. pombe) 63.02(n)
    56.83(a)
      427918  XM_004937874.1  XP_004937931.1 
    lizard
    (Anolis carolinensis)
    Reptilia WEE26
    WEE1 homolog 2 (S. pombe)
    50(a)
    1 ↔ 1
    5(16166056-16184640)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wee21 WEE1 homolog 2 56.62(n)
    52.31(a)
      100125126  XM_004912469.1  XP_004912526.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wee21 WEE1 homolog 2 (S. pombe) 58.17(n)
    54.55(a)
      327471  NM_001044902.1  NP_001038367.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wee6
    wee
    30(a)
    1 → many
    2L(6911090-6914138)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWE16
    Protein kinase that regulates the G2/M transition ...
    14(a)
    1 → many
    X(76803-79262) YJL187C


    ENSEMBL Gene Tree for WEE2 (if available)
    TreeFam Gene Tree for WEE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WEE2 gene
    WEE12  PKMYT12  
    3 SIMAP similar genes for WEE2 using alignment to 2 protein entries:     WEE2_HUMAN (see all proteins):
    DKFZp686I18166    WEE1    DKFZp564L2416

    Find genes that share paralogs with WEE2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for WEE2
    PGOHUM00000242209


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    8 SNPs for WEE2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413054
    A gastric adenocarcinoma sample4--see VAR_0413052 N K mis40--------
    VAR_0413064
    An ovarian mucinous carcinoma sample4--see VAR_0413062 R H mis40--------
    rs1834519411,2
    --144792923(+) CTCTCG/TCTCGC 1 -- ds50010--------
    rs559010991,2,4
    ----see VAR_0413072 mis40--------
    rs356836591,2,4
    ----see VAR_0413082 mis40--------
    rs356727881,2,4
    ----see VAR_0413042 mis40--------
    rs1419136721,2
    ----144792927(+) CTCTCG/TCTCTC 1 -- ds50010--------
    rs1499374981,2
    ----144792907(+) CTCTCG/TCTCTC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for WEE2 (141408153 - 141431071 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WEE2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34135CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WEE2
    DNA2.0 Custom Variant and Variant Library Synthesis for WEE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614084    OMIM disorders: --

    1 disease for WEE2:    
    About MalaCards
    western equine encephalitis

    2 diseases from the University of Copenhagen DISEASES database for WEE2:
    Western equine encephalitis     Subacute thyroiditis

    Find genes that share disorders with WEE2           About GenesLikeMe


    Export disorders for WEE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WEE2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with WEE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. (PubMed id 11029659)1, 2 Nakanishi M.... Sasaki M. (Genes Cells 2000)
    3. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    4. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    7. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 494551 HGNC: 19684 Ensembl:ENSG00000214102 euGenes: HUgn494551 ECgene: WEE2 Kegg: 494551
    H-InvDB: WEE2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WEE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WEE2 gene:
    Search GeneIP for patents involving WEE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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