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Aliases for WEE2 Gene

Aliases for WEE2 Gene

  • WEE1 Homolog 2 2 3 5
  • Wee1-Like Protein Kinase 1B 3 4
  • Wee1B Kinase 3 4
  • EC 2.7.10.2 4 58
  • WEE1B 3 4
  • Wee1-Like Protein Kinase 2 3
  • WEE1 Homolog 2 (S. Pombe) 2
  • EC 2.7.10 58

External Ids for WEE2 Gene

Previous GeneCards Identifiers for WEE2 Gene

  • GC07U901539
  • GC07P141055
  • GC07P141409
  • GC07P135704

Summaries for WEE2 Gene

GeneCards Summary for WEE2 Gene

WEE2 (WEE1 Homolog 2) is a Protein Coding gene. Among its related pathways are Cell cycle. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WEE1.

UniProtKB/Swiss-Prot for WEE2 Gene

  • Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at Tyr-15, leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at Tyr-15, to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).

Additional gene information for WEE2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WEE2 Gene

Genomics for WEE2 Gene

Regulatory Elements for WEE2 Gene

Enhancers for WEE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H141736 1.2 ENCODE 12.4 +30.0 29989 3 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC WEE2-AS1 TAS2R6P TAS2R5 PRSS37 WEE2 KIAA1147 SSBP1 TAS2R4
GH07H141649 1.3 Ensembl ENCODE dbSUPER 11.2 -58.3 -58308 1 CTCF MXI1 PKNOX1 MAX SIN3A BMI1 RAD21 RFX5 GATA3 ZNF143 KIAA1147 WEE2 AGK ENSG00000244701 ENSG00000261570
GH07H141673 1.1 Ensembl ENCODE dbSUPER 11.8 -33.0 -32951 3 CTCF JUN REST RAD21 NR2F2 ZFHX2 POLR2A RUNX3 EGR2 WEE2-AS1 KIAA1147 WEE2 GC07M141687 ENSG00000270157 PIR58736
GH07H141662 1.1 ENCODE dbSUPER 11.1 -44.6 -44627 3 ELF3 HNRNPUL1 FOXA2 NFIB SIN3A RAD21 YY1 FOS ZNF217 MTA1 KIAA1147 WEE2 TAS2R5 ENSG00000270157 ENSG00000244701 WEE2-AS1 PIR48863
GH07H141654 1.1 ENCODE dbSUPER 11 -53.6 -53632 0 RB1 NFXL1 RAD21 ZNF143 RCOR1 RUNX3 MIXL1 THAP11 ZNF202 ZNF654 TAS2R6P TAS2R5 KIAA1147 WEE2 AGK WEE2-AS1 ENSG00000244701 ENSG00000261570
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WEE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for WEE2 Gene

Chromosome:
7
Start:
141,708,353 bp from pter
End:
141,731,271 bp from pter
Size:
22,919 bases
Orientation:
Plus strand

Genomic View for WEE2 Gene

Genes around WEE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WEE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WEE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WEE2 Gene

Proteins for WEE2 Gene

  • Protein details for WEE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C1S8-WEE2_HUMAN
    Recommended name:
    Wee1-like protein kinase 2
    Protein Accession:
    P0C1S8

    Protein attributes for WEE2 Gene

    Size:
    567 amino acids
    Molecular mass:
    62925 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WEE2 Gene

Selected DME Specific Peptides for WEE2 Gene

P0C1S8:
  • WAEDDHM
  • LGHHPHV
  • VEEGDSRFLANE

Post-translational modifications for WEE2 Gene

Other Protein References for WEE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for WEE2 Gene

Gene Families for WEE2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WEE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C1S8

UniProtKB/Swiss-Prot:

WEE2_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
genes like me logo Genes that share domains with WEE2: view

Function for WEE2 Gene

Molecular function for WEE2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at Tyr-15, leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at Tyr-15, to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).

Enzyme Numbers (IUBMB) for WEE2 Gene

Gene Ontology (GO) - Molecular Function for WEE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with WEE2: view

Phenotypes for WEE2 Gene

genes like me logo Genes that share phenotypes with WEE2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WEE2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WEE2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WEE2 Gene

Localization for WEE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WEE2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WEE2 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WEE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with WEE2: view

Pathways & Interactions for WEE2 Gene

SuperPathway Contained pathways
1 Cell cycle
genes like me logo Genes that share pathways with WEE2: view

Pathways by source for WEE2 Gene

1 GeneTex pathway for WEE2 Gene
1 KEGG pathway for WEE2 Gene

Gene Ontology (GO) - Biological Process for WEE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007143 female meiotic division IEA,ISS --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with WEE2: view

No data available for SIGNOR curated interactions for WEE2 Gene

Drugs & Compounds for WEE2 Gene

(1) Drugs for WEE2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MK-1775 Investigational Pharma Wee1 kinase inhibtor,potent and ATP-competitive, Others 0

(1) ApexBio Compounds for WEE2 Gene

Compound Action Cas Number
MK-1775 Wee1 kinase inhibtor,potent and ATP-competitive 955365-80-7
genes like me logo Genes that share compounds with WEE2: view

Drug Products

Transcripts for WEE2 Gene

mRNA/cDNA for WEE2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WEE2 Gene

WEE1 homolog 2 (S. pombe):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WEE2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WEE2 Gene

No ASD Table

Relevant External Links for WEE2 Gene

GeneLoc Exon Structure for
WEE2
ECgene alternative splicing isoforms for
WEE2

Expression for WEE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WEE2 Gene

Protein differential expression in normal tissues from HIPED for WEE2 Gene

This gene is overexpressed in Platelet (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WEE2 Gene



Protein tissue co-expression partners for WEE2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WEE2 Gene:

WEE2

SOURCE GeneReport for Unigene cluster for WEE2 Gene:

Hs.657927

mRNA Expression by UniProt/SwissProt for WEE2 Gene:

P0C1S8-WEE2_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with WEE2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WEE2 Gene

Orthologs for WEE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WEE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WEE2 33 34
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia WEE2 33 34
  • 83.78 (n)
cow
(Bos Taurus)
Mammalia WEE2 33 34
  • 80.52 (n)
mouse
(Mus musculus)
Mammalia Wee2 33 16 34
  • 77.8 (n)
rat
(Rattus norvegicus)
Mammalia Wee2 33
  • 76.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WEE2 34
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WEE2 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves WEE2 33 34
  • 63.02 (n)
lizard
(Anolis carolinensis)
Reptilia WEE2 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wee2 33
  • 56.62 (n)
zebrafish
(Danio rerio)
Actinopterygii wee2 33 34
  • 58.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta wee 34
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWE1 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7177 34
  • 39 (a)
OneToMany
Species where no ortholog for WEE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WEE2 Gene

ENSEMBL:
Gene Tree for WEE2 (if available)
TreeFam:
Gene Tree for WEE2 (if available)

Paralogs for WEE2 Gene

Paralogs for WEE2 Gene

(3) SIMAP similar genes for WEE2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for WEE2 Gene

genes like me logo Genes that share paralogs with WEE2: view

Variants for WEE2 Gene

Sequence variations from dbSNP and Humsavar for WEE2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs200610853 An ovarian mucinous carcinoma sample
VAR_041305 A gastric adenocarcinoma sample
rs35672788 --
rs35683659 --
rs55901099 --

Structural Variations from Database of Genomic Variants (DGV) for WEE2 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV loss 18971310

Variation tolerance for WEE2 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WEE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WEE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WEE2 Gene

Disorders for WEE2 Gene

Relevant External Links for WEE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WEE2

No disorders were found for WEE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WEE2 Gene

Publications for WEE2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. (PMID: 11029659) Nakanishi M … Sasaki M (Genes to cells : devoted to molecular & cellular mechanisms 2000) 3 4 60
  3. Genetic variants associated with disordered eating. (PMID: 23568457) Wade TD … Martin NG (The International journal of eating disorders 2013) 3 60
  4. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PMID: 22623531) Toyoshima M … Grandori C (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 60
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 60

Products for WEE2 Gene

Sources for WEE2 Gene

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