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Aliases for WEE2 Gene

Aliases for WEE2 Gene

  • WEE1 Homolog 2 (S. Pombe) 2 3 5
  • Wee1-Like Protein Kinase 1B 3 4
  • Wee1B Kinase 3 4
  • EC 2.7.10.2 4 63
  • WEE1B 3 4
  • EC 2.7.10 63

External Ids for WEE2 Gene

Previous GeneCards Identifiers for WEE2 Gene

  • GC07U901539
  • GC07P141055
  • GC07P141409
  • GC07P135704

Summaries for WEE2 Gene

GeneCards Summary for WEE2 Gene

WEE2 (WEE1 Homolog 2 (S. Pombe)) is a Protein Coding gene. Among its related pathways are Cell cycle. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PKMYT1.

UniProtKB/Swiss-Prot for WEE2 Gene

  • Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at Tyr-15, leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at Tyr-15, to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WEE2 Gene

Genomics for WEE2 Gene

Regulatory Elements for WEE2 Gene

Genomic Location for WEE2 Gene

Chromosome:
7
Start:
141,708,353 bp from pter
End:
141,731,271 bp from pter
Size:
22,919 bases
Orientation:
Plus strand

Genomic View for WEE2 Gene

Genes around WEE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WEE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WEE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WEE2 Gene

Proteins for WEE2 Gene

  • Protein details for WEE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C1S8-WEE2_HUMAN
    Recommended name:
    Wee1-like protein kinase 2
    Protein Accession:
    P0C1S8

    Protein attributes for WEE2 Gene

    Size:
    567 amino acids
    Molecular mass:
    62925 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WEE2 Gene

Proteomics data for WEE2 Gene at MOPED

Selected DME Specific Peptides for WEE2 Gene

Post-translational modifications for WEE2 Gene

Other Protein References for WEE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for WEE2 Gene

Gene Families for WEE2 Gene

Suggested Antigen Peptide Sequences for WEE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C1S8

UniProtKB/Swiss-Prot:

WEE2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
genes like me logo Genes that share domains with WEE2: view

Function for WEE2 Gene

Molecular function for WEE2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at Tyr-15, leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at Tyr-15, to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).

Enzyme Numbers (IUBMB) for WEE2 Gene

Gene Ontology (GO) - Molecular Function for WEE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
genes like me logo Genes that share ontologies with WEE2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WEE2

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WEE2 Gene

Localization for WEE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WEE2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WEE2 Gene COMPARTMENTS Subcellular localization image for WEE2 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for WEE2 Gene

Pathways & Interactions for WEE2 Gene

SuperPathways for WEE2 Gene

Superpath Contained pathways
1 Cell cycle
genes like me logo Genes that share pathways with WEE2: view

Pathways by source for WEE2 Gene

1 GeneTex pathway for WEE2 Gene
1 KEGG pathway for WEE2 Gene

Gene Ontology (GO) - Biological Process for WEE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0007143 female meiotic division IEA,ISS --
GO:0035038 female pronucleus assembly IEA,ISS --
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0060631 regulation of meiosis I IEA,ISS --
genes like me logo Genes that share ontologies with WEE2: view

No data available for SIGNOR curated interactions for WEE2 Gene

Drugs & Compounds for WEE2 Gene

(1) Drugs for WEE2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Resveratrol Experimental, Investigational Pharma Wee1 kinase inhibtor,potent and ATP-competitive, Others, Cyclooxygenase inhibitor 105

(1) ApexBio Compounds for WEE2 Gene

Compound Action Cas Number
MK-1775 Wee1 kinase inhibtor,potent and ATP-competitive 955365-80-7
genes like me logo Genes that share compounds with WEE2: view

Transcripts for WEE2 Gene

mRNA/cDNA for WEE2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WEE2 Gene

WEE1 homolog 2 (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WEE2 Gene

No ASD Table

Relevant External Links for WEE2 Gene

GeneLoc Exon Structure for
WEE2
ECgene alternative splicing isoforms for
WEE2

Expression for WEE2 Gene

mRNA expression in normal human tissues for WEE2 Gene

Protein differential expression in normal tissues from HIPED for WEE2 Gene

This gene is overexpressed in Platelet (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WEE2 Gene



SOURCE GeneReport for Unigene cluster for WEE2 Gene Hs.657927

mRNA Expression by UniProt/SwissProt for WEE2 Gene

P0C1S8-WEE2_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with WEE2: view

Protein tissue co-expression partners for WEE2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WEE2 Gene

Orthologs for WEE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WEE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WEE2 35
  • 80.52 (n)
  • 74.07 (a)
WEE2 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WEE2 35
  • 83.78 (n)
  • 79.22 (a)
WEE2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wee2 35
  • 77.8 (n)
  • 68.98 (a)
Wee2 16
Wee2 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WEE2 35
  • 99.76 (n)
  • 99.65 (a)
WEE2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wee2 35
  • 76.82 (n)
  • 68.41 (a)
oppossum
(Monodelphis domestica)
Mammalia WEE2 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WEE2 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves WEE2 35
  • 63.02 (n)
  • 56.83 (a)
WEE2 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WEE2 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wee2 35
  • 56.62 (n)
  • 52.31 (a)
zebrafish
(Danio rerio)
Actinopterygii wee2 35
  • 58.17 (n)
  • 54.55 (a)
wee2 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wee 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWE1 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7177 36
  • 39 (a)
OneToMany
Species with no ortholog for WEE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WEE2 Gene

ENSEMBL:
Gene Tree for WEE2 (if available)
TreeFam:
Gene Tree for WEE2 (if available)

Paralogs for WEE2 Gene

Paralogs for WEE2 Gene

(3) SIMAP similar genes for WEE2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for WEE2 Gene

genes like me logo Genes that share paralogs with WEE2: view

Variants for WEE2 Gene

Sequence variations from dbSNP and Humsavar for WEE2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_041304 -
VAR_041305 A gastric adenocarcinoma sample
VAR_041306 An ovarian mucinous carcinoma sample
VAR_041307 -
VAR_041308 -

Structural Variations from Database of Genomic Variants (DGV) for WEE2 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV Loss 18971310

Variation tolerance for WEE2 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WEE2 Gene

HapMap Linkage Disequilibrium report
WEE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WEE2 Gene

Disorders for WEE2 Gene

Relevant External Links for WEE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WEE2

No disorders were found for WEE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WEE2 Gene

Publications for WEE2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3
  3. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PMID: 22623531) Toyoshima M. … Grandori C. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for WEE2 Gene

Sources for WEE2 Gene

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