Aliases for WEE2 Gene
External Ids for WEE2 Gene
Previous GeneCards Identifiers for WEE2 Gene
GeneCards Summary for WEE2 Gene
WEE2 (WEE1 Homolog 2 (S. Pombe)) is a Protein Coding gene. Diseases associated with WEE2 include western equine encephalitis. Among its related pathways are Cell cycle. GO annotations related to this gene include protein serine/threonine kinase activity and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is PKMYT1.
UniProtKB/Swiss-Prot for WEE2 Gene
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at Tyr-15, leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at Tyr-15, to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).