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Aliases for WEE1 Gene

Aliases for WEE1 Gene

  • WEE1 G2 Checkpoint Kinase 2 3
  • Wee1A Kinase 3 4
  • EC 2.7.10.2 4 63
  • WEE1hu 3 4
  • Wee1+ (S. Pombe) Homolog 2
  • Wee1-Like Protein Kinase 3
  • WEE1 Homolog (S. Pombe) 2
  • WEE1+ Homolog 3
  • WEE1 Homolog 3
  • WEE1A 3

External Ids for WEE1 Gene

Previous GeneCards Identifiers for WEE1 Gene

  • GC11P010605
  • GC11P010164
  • GC11P009633
  • GC11P009558
  • GC11P009550
  • GC11P009266
  • GC11P009595

Summaries for WEE1 Gene

Entrez Gene Summary for WEE1 Gene

  • This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]

GeneCards Summary for WEE1 Gene

WEE1 (WEE1 G2 Checkpoint Kinase) is a Protein Coding gene. Diseases associated with WEE1 include suppurative lymphadenitis. Among its related pathways are ERK Signaling and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is WEE2.

UniProtKB/Swiss-Prot for WEE1 Gene

  • Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on Tyr-15. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on Tyr-15 and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation

Gene Wiki entry for WEE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WEE1 Gene

Genomics for WEE1 Gene

Regulatory Elements for WEE1 Gene

Transcription factor binding sites by QIAGEN in the WEE1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WEE1 Gene

Start:
9,573,650 bp from pter
End:
9,593,468 bp from pter
Size:
19,819 bases
Orientation:
Plus strand

Genomic View for WEE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WEE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WEE1 Gene

Proteins for WEE1 Gene

  • Protein details for WEE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30291-WEE1_HUMAN
    Recommended name:
    Wee1-like protein kinase
    Protein Accession:
    P30291
    Secondary Accessions:
    • B3KVE1
    • D3DQV0

    Protein attributes for WEE1 Gene

    Size:
    646 amino acids
    Molecular mass:
    71597 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for WEE1 Gene

    Alternative splice isoforms for WEE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WEE1 Gene

Proteomics data for WEE1 Gene at MOPED

Selected DME Specific Peptides for WEE1 Gene

Post-translational modifications for WEE1 Gene

  • Dephosphorylated at Thr-239 by CTDP1
  • Phosphorylated during M and G1 phases. Also autophosphorylated. Phosphorylation at Ser-642 by BRSK1 and BRSK2 in post-mitotic neurons, leads to down-regulate WEE1 activity in polarized neurons. Phosphorylated at Ser-53 and Ser-123 by PLK1 and CDK1, respectively, generating an signal for degradation that can be recognized by the SCF(BTRC) complex, leading to its ubiquitination and degradation at the onset of G2/M phase.
  • Ubiquitinated and degraded at the onset of G2/M phase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WEE1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WEE1 (Wee1)

Domains for WEE1 Gene

Gene Families for WEE1 Gene

Graphical View of Domain Structure for InterPro Entry

P30291

UniProtKB/Swiss-Prot:

WEE1_HUMAN :
  • P30291
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
genes like me logo Genes that share domains with WEE1: view

Function for WEE1 Gene

Molecular function for WEE1 Gene

GENATLAS Biochemistry: wee1 tyrosine kinase,yeast wee1 homolog,involved in cell cycle regulation
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Synthesis is increased during S and G2 phases, presumably by an increase in transcription; activity is decreased by phosphorylation during m phase. Protein levels fall in M phase as a result of decreased synthesis combined with degradation. Activity seems to be negatively regulated by phosphorylation upon entry into mitosis, although N-terminal phosphorylation might also regulate the protein stability via protection from proteolysis or might regulate the subcellular location
UniProtKB/Swiss-Prot Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on Tyr-15. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on Tyr-15 and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation

Enzyme Numbers (IUBMB) for WEE1 Gene

Gene Ontology (GO) - Molecular Function for WEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004713 protein tyrosine kinase activity TAS 7774574
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with WEE1: view
genes like me logo Genes that share phenotypes with WEE1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WEE1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for WEE1 Gene

Localization for WEE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WEE1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WEE1 Gene COMPARTMENTS Subcellular localization image for WEE1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8348613
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with WEE1: view

Pathways for WEE1 Gene

genes like me logo Genes that share pathways with WEE1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for WEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0000278 mitotic cell cycle TAS --
GO:0006468 protein phosphorylation --
genes like me logo Genes that share ontologies with WEE1: view

Compounds for WEE1 Gene

(3) HMDB Compounds for WEE1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(4) Novoseek inferred chemical compound relationships for WEE1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 53.8 21
berberine 36.1 5
curcumin 31 3
oxygen 0 1
genes like me logo Genes that share compounds with WEE1: view

Transcripts for WEE1 Gene

Unigene Clusters for WEE1 Gene

WEE1 homolog (S. pombe):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WEE1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WEE1 Gene

No ASD Table

Relevant External Links for WEE1 Gene

GeneLoc Exon Structure for
WEE1
ECgene alternative splicing isoforms for
WEE1

Expression for WEE1 Gene

mRNA expression in normal human tissues for WEE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WEE1 Gene

SOURCE GeneReport for Unigene cluster for WEE1 Gene Hs.249441

genes like me logo Genes that share expressions with WEE1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WEE1 Gene

Orthologs for WEE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WEE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WEE1 35
  • 99.17 (n)
  • 99.54 (a)
WEE1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WEE1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WEE1 35
  • 93.24 (n)
  • 97.06 (a)
WEE1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wee1 35
  • 87.06 (n)
  • 90.68 (a)
Wee1 16
Wee1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WEE1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WEE1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wee1 35
  • 88.35 (n)
  • 91.77 (a)
chicken
(Gallus gallus)
Aves WEE1 35
  • 77.05 (n)
  • 81.31 (a)
WEE1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WEE1 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17393 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5859 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28346 35
wee1 35
  • 65.76 (n)
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007798 35
  • 26.82 (n)
  • 12.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta wee 35
  • 51.51 (n)
  • 49.42 (a)
wee 36
  • 36 (a)
OneToMany
wee 37
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWE1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3882 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7177 36
  • 43 (a)
OneToMany
Species with no ortholog for WEE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WEE1 Gene

ENSEMBL:
Gene Tree for WEE1 (if available)
TreeFam:
Gene Tree for WEE1 (if available)

Paralogs for WEE1 Gene

Paralogs for WEE1 Gene

Selected SIMAP similar genes for WEE1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with WEE1: view

Variants for WEE1 Gene

Sequence variations from dbSNP and Humsavar for WEE1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10534 -- 9,589,461(-) AAAAA(A/C)AGACT utr-variant-3-prime, intron-variant
rs1049403 -- 9,589,258(+) TGATG(A/G)AAAGC utr-variant-3-prime, intron-variant
rs2305500 -- 9,586,432(+) AAAAA(C/T)TGTTT intron-variant
rs2872220 -- 9,593,912(-) ATAAT(A/C)ATCCT downstream-variant-500B
rs3763868 -- 9,573,341(-) ACGCA(C/G/T)CCCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WEE1 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
nsv7672 CNV Insertion 18451855
esv2744094 CNV Deletion 23290073

Relevant External Links for WEE1 Gene

HapMap Linkage Disequilibrium report
WEE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WEE1 Gene

Disorders for WEE1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for WEE1 Gene including...

Search for WEE1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for WEE1 Gene

(6) Novoseek inferred disease relationships for WEE1 Gene

Disease -log(P) Hits PubMed IDs
beckwith-wiedemann syndrome 40.1 1
cancer 18.8 5
tumors 3.68 7
leukemia 0 2
cancer lung 0 2

Relevant External Links for WEE1

Genetic Association Database (GAD)
WEE1
Human Genome Epidemiology (HuGE) Navigator
WEE1
Tumor Gene Database (TGDB):
WEE1
genes like me logo Genes that share disorders with WEE1: view

No data available for UniProtKB/Swiss-Prot for WEE1 Gene

Publications for WEE1 Gene

  1. Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. (PMID: 8428596) McGowan C.H. … Russell P. (EMBO J. 1993) 3 4 23
  2. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. (PMID: 7743995) Watanabe N. … Hunter T. (EMBO J. 1995) 3 4 23
  3. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). (PMID: 11528126) Cichutek A. … Zabel B.U. (Cytogenet. Cell Genet. 2001) 3 4 23
  4. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. (PMID: 15070733) Watanabe N. … Osada H. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  5. Wee1(+)-like gene in human cells. (PMID: 1840647) Igarashi M. … Okayama H. (Nature 1991) 2 3 4

Products for WEE1 Gene

Sources for WEE1 Gene

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