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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WEE1 Gene

protein-coding   GIFtS: 71
GCID: GC11P009595

WEE1 Homolog (S. Pombe)

(Previous name: wee1+ (S. pombe) homolog)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WEE1 Homolog (S. Pombe)1 2     Wee1+ (S. Pombe) Homolog1
Wee1A Kinase2 3     WEE1A2
WEE1hu2 3     WEE1+ Homolog2
EC 2.7.10.23 8     Wee1-Like Protein Kinase2

External Ids:    HGNC: 127611   Entrez Gene: 74652   Ensembl: ENSG000001664837   OMIM: 1935255   UniProtKB: P302913   

Export aliases for WEE1 gene to outside databases

Previous GC identifers: GC11P010605 GC11P010164 GC11P009633 GC11P009558 GC11P009550 GC11P009266


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WEE1 Gene:
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein
kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to
coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically
activated CDC2 kinase. (provided by RefSeq, Jul 2008)

GeneCards Summary for WEE1 Gene: 
WEE1 (WEE1 homolog (S. pombe)) is a protein-coding gene. Diseases associated with WEE1 include suppurative lymphadenitis, and lymphadenitis, and among its related super-pathways are Mitotic G1-G1/S phases and Cell cycle. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is WEE2.

UniProtKB/Swiss-Prot: WEE1_HUMAN, P30291
Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from
cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of
CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during
G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15'
and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases
at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably
due to its degradation

Gene Wiki entry for WEE1 (Wee1-like protein kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WEE1 gene promoter:
         p53   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): WEE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for WEE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WEE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3-p15.1   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.3-p15.1

WEE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WEE1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P009595:  view genomic region     (about GC identifiers)

Start:
9,595,228 bp from pter      End:
9,615,004 bp from pter
Size:
19,777 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WEE1_HUMAN, P30291 (See protein sequence)
Recommended Name: Wee1-like protein kinase  
Size: 646 amino acids; 71597 Da
Cofactor: Binds 2 magnesium ions per subunit
Subcellular location: Nucleus
6/8 PDB 3D structures from and Proteopedia for WEE1 (see all 8):
1X8B (3D)        2IN6 (3D)        2IO6 (3D)        2Z2W (3D)        3BI6 (3D)        3BIZ (3D)    
Secondary accessions: B3KVE1 D3DQV0
Alternative splicing: 2 isoforms:  P30291-1   P30291-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WEE1: NX_P30291

Explore proteomics data for WEE1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated during M and G1 phases. Also autophosphorylated. Phosphorylation at Ser-642 by BRSK1 and BRSK2 in
    post-mitotic neurons, leads to down-regulate WEE1 activity in polarized neurons. Phosphorylated at Ser-53 and
    Ser-123 by PLK1 and CDK1, respectively, generating an signal for degradation that can be recognized by the
    SCF(BTRC) complex, leading to its ubiquitination and degradation at the onset of G2/M phase
  • UniProtKB: Dephosphorylated at Thr-239 by CTDP1
  • UniProtKB: Ubiquitinated and degraded at the onset of G2/M phase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30291

  • 4/5 DME Specific Peptides for WEE1 (P30291) (see all 5)
     WAEDDHM  RLDGCIYAIK  VEEGDSRFLANE  YAIKRSKKPLAGS 

    WEE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WEE1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137448.1  NP_003381.1  

    ENSEMBL proteins: 
     ENSP00000402084   ENSP00000299613   ENSP00000434446   ENSP00000434148   ENSP00000435945  
     ENSP00000432284  
    Reactome Protein details: P30291
    Human Recombinant Protein Products for WEE1: 
    EMD Millipore Purified and/or Recombinant WEE1 Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for WEE1
    OriGene Protein Over-expression Lysate for WEE1
    OriGene MassSpec for WEE1 
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    Novus Biologicals WEE1 Proteins
    Novus Biologicals WEE1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WEE1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8348613
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--

    WEE1 for ontologies           About GeneDecksing



    WEE1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of WEE1
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    Assay Products for WEE1: 
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    Cloud-Clone Corp. ELISAs for WEE1 
    Cloud-Clone Corp. CLIAs for WEE1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: WEE1 homolog (S. pombe) 
    WEE family

    5 InterPro protein domains:
     IPR017164 Wee1-like_protein_kinase
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P30291

    ProtoNet protein and cluster: P30291

    UniProtKB/Swiss-Prot: WEE1_HUMAN, P30291
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily
    Similarity: Contains 1 protein kinase domain


    WEE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WEE1_HUMAN, P30291
    Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from
    cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of
    CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during
    G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15'
    and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases
    at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably
    due to its degradation
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Synthesis is increased during S and G2 phases, presumably by an increase in transcription;
    activity is decreased by phosphorylation during m phase. Protein levels fall in M phase as a result of decreased
    synthesis combined with degradation. Activity seems to be negatively regulated by phosphorylation upon entry into
    mitosis, although N-terminal phosphorylation might also regulate the protein stability via protection from
    proteolysis or might regulate the subcellular location

         Genatlas biochemistry entry for WEE1:
    wee1 tyrosine kinase,yeast wee1 homolog,involved in cell cycle regulation

         Enzyme Number (IUBMB): EC 2.7.10.21 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity TAS7774574
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
         
    WEE1 for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for WEE1:
     Cell cycle / mitosis defect  Decreased cell number, increas  Decreased substrate adherent c  Gemcitabine induced cell-death 
     Increased cell death in HCC-19  Increased cell number in S  Increased number of mitotic ce  S arrest 
     Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Wee1 (no phenotypes)

    WEE1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WEE1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WEE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WEE1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WEE1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target WEE1:
    hsa-mir-17 (MIRT005853), hsa-mir-195 (MIRT000222), hsa-mir-106b (MIRT005868), hsa-mir-424 (MIRT000659), hsa-mir-20a (MIRT005860), hsa-mir-503 (MIRT000644), hsa-mir-372 (MIRT000057)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WEE1
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate WEE1 (see all 45):
    hsa-miR-520e hsa-miR-302d hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-219-5p hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidWEE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): WEE1 (NM_003390)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WEE1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WEE1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WEE1 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    4CDK-mediated phosphorylation and removal of Cdc6
    Cyclin E associated events during G1/S transition 0.89
    S Phase0.79
    Cyclin A:Cdk2-associated events at S phase entry0.88
    Cell Cycle Checkpoints0.58
    5Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
    Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex0.56
    G2/M DNA replication checkpoint0.50
    G2/M DNA damage checkpoint0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for WEE1
        Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle Role of SCF complex in cell cycle regulation

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WEE1
        14-3-3 and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation
    Molecular Mechanisms of Cancer
    Mitotic Roles of Polo Like Kinases

    2 Cell Signaling Technology (CST) Pathways for WEE1
        Cell Cycle / Checkpoint Control
    DNA Damage

    2 GeneGo (Thomson Reuters) Pathways for WEE1
        Cell cycle Role of SCF complex in cell cycle regulation
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    4 BioSystems Pathways for WEE1
        Cell cycle
    G1 to S cell cycle control
    Integrated Breast Cancer Pathway
    PLK1 signaling events

    5/18        Reactome Pathways for WEE1 (see all 18)
        Mitotic G1-G1/S phases
    Cell Cycle
    S Phase
    Factors involved in megakaryocyte development and platelet production
    G2/M Transition


    1         Kegg Pathway  (Kegg details for WEE1):
        Cell cycle


    WEE1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WEE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for WEE1 (P302911, 2, 3 ENSP000004020844) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-16603 MINT-16602 MINT-50988 I2D: score=4 STRING: ENSP00000300161
    YWHAZP631042, 3MINT-3294834 MINT-3294458 MINT-3295375 I2D: score=2 
    BTRCQ9Y2971, 3, ENSP000003592064EBI-914695,EBI-307461 I2D: score=4 STRING: ENSP00000359206
    SFNP319472, 3, ENSP000003409894MINT-3975741 I2D: score=2 STRING: ENSP00000340989
    FBXW11Q9UKB11, 3, ENSP000002650944EBI-914695,EBI-355189 I2D: score=4 STRING: ENSP00000265094
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0000278mitotic cell cycle TAS--
    GO:0006468protein phosphorylation ----

    WEE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WEE1 for compounds           About GeneDecksing

    EMD Millipore small molecules for WEE1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WEE1

    3 HMDB Compounds for WEE1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    6 DrugBank Compounds for WEE1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID-- --target--10592235
    4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione-- --target--10592235
    8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide-- --target--10592235
    9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE-- --target--10592235
    9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE-- --target--10592235
    N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE-- --target--10592235

    4 Novoseek inferred chemical compound relationships for WEE1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 53.8 24 14711880 (2), 7813446 (2), 1384126 (1), 15558017 (1) (see all 19)
    berberine 36.1 5 16619512 (4), 16440412 (1)
    curcumin 31 3 17201156 (1), 14534529 (1), 16596191 (1)
    oxygen 0 1 17201156 (1)

    Search CenterWatch for drugs/clinical trials and news about WEE1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WEE1 gene (2 alternative transcripts): 
    NM_001143976.1  NM_003390.3  

    Unigene Cluster for WEE1:

    WEE1 homolog (S. pombe)
    Hs.249441  [show with all ESTs]
    Unigene Representative Sequence: BC070052
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450114(uc001mhs.3) ENST00000299613(uc001mht.3) ENST00000524549(uc001mhu.3)
    ENST00000524612 ENST00000530712 ENST00000530175 ENST00000532275 ENST00000527848

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate WEE1 (see all 45):
    hsa-miR-520e hsa-miR-302d hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-219-5p hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidWEE1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): WEE1 (NM_003390)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WEE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WEE1
    Sirion Biotech Customized lentivirus for stable overexpression of WEE1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WEE1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WEE1

    Additional mRNA sequence: 

    AK122837.1 BC051831.1 BC070052.1 U10564.1 X62048.1 

    8 DOTS entries:

    DT.315661  DT.95290127  DT.92432867  DT.95373536  DT.100036218  DT.100787721  DT.120680022  DT.120680029 

    24/226 AceView cDNA sequences (see all 226):

    BU752866 AI961592 BM718727 BM695000 AU125150 AI473778 AI474012 BG611243 
    CD517624 AK122837 AW949527 AU143572 BU161880 BE349189 CB113055 BQ024511 
    BX117974 AW630943 AU126299 U10564 AA554199 CB149989 BF478052 AI589239 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WEE1 expression in normal human tissues (normalized intensities)      WEE1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGCACTTG
    WEE1 Expression
    About this image


    WEE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             testis ; cells in seminiferus ducts   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; squamous epithelial cells   
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             placenta ; decidual cells   
     
     Nose (Sensory Organs)
             nasopharynx ; respiratory epithelial cells   

    See WEE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WEE1

    SOURCE GeneReport for Unigene cluster: Hs.249441
        SABiosciences Expression via Pathway-Focused PCR Arrays including WEE1: 
              Cell Cycle in human mouse rat
              Circadian Rhythms in human mouse rat
              Cancer PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WEE1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wee11 , 5 WEE 1 homolog 1 (S. pombe)1, 5 87.22(n)1
    90.84(a)1
      7 (57.70 cM)5
    223901  NM_009516.31  NP_033542.21 
     1101223505 
    chicken
    (Gallus gallus)
    Aves WEE11 WEE1 homolog (S. pombe) 77.19(n)
    81.5(a)
      423045  NM_001031181.2  NP_001026352.2 
    lizard
    (Anolis carolinensis)
    Reptilia WEE16
    WEE1 homolog (S. pombe)
    74(a)
    1 ↔ 1
    1(64142847-64158598)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.173932 Xenopus laevis mRNA for Wee1B kinase, complete cds 80.09(n)    AB071983.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283462 Danio rerio cDNA clone IMAGE3815602, partial cds 77.65(n)    BC058071.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wee1 , 3 mitotic checkpoint protein tyrosine
    kinase3
    CG4488-PA1
    43(a)3
    50.87(n)1
    48.75(a)1
      2 27C43
    339651  NM_057687.31  NP_477035.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWE16
    Protein kinase that regulates the G2/M transition ...
    13(a)
    1 → many
    X(76803-79262)


    ENSEMBL Gene Tree for WEE1 (if available)
    TreeFam Gene Tree for WEE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WEE1 gene
    WEE22  PKMYT12  
    2 SIMAP similar genes for WEE1 using alignment to 7 protein entries:     WEE1_HUMAN (see all proteins):
    DKFZp686I18166    WEE2

    WEE1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for WEE1
    PGOHUM00000236992 PGOHUM00000237324 PGOHUM00000245419 PGOHUM00000245420 PGOHUM00000245423


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/368 SNPs in WEE1 are shown (see all 368)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37638721,2
    C,F,A,H--9593427(-) ACATCG/AGTGGA 1 -- us2k124Minor allele frequency- A:0.32EA NS NA WA CSA 3839
    rs79406721,2
    C,F--9593574(+) ggccaG/Agcgcg 1 -- us2k16Minor allele frequency- A:0.16NA WA EA 364
    rs1901861011,2
    --9593608(+) CACTTC/TGGGAG 1 -- us2k10--------
    rs1453731771,2
    C--9593627(+) GGGCAC/GATCAC 1 -- us2k10--------
    rs1826376821,2
    --9593668(+) AACATA/GGTGAA 1 -- us2k10--------
    rs1873177221,2
    --9593781(+) AACCCA/GGGAGG 1 -- us2k10--------
    rs113703751,2
    C--9593857(+) TGTCGA/-AAAAA 1 -- us2k12Minor allele frequency- -:0.25NA CSA 4
    rs754099041,2
    C--9593870(+) CCAAAC/GCAAAC 1 -- us2k13Minor allele frequency- G:0.06NA WA 240
    rs618768301,2
    C--9594137(+) CGCTTC/GAACTC 1 -- us2k10--------
    rs37638711,2
    C--9594235(-) TTTTTA/TTTTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for WEE1 (9595228 - 9615004 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WEE1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744094CNV Deletion23290073
    nsv7672CNV Insertion18451855
    nsv499766OTHER Inversion21111241
    nsv7215OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 193525    OMIM disorders: --

    20/27 diseases for WEE1 (see all 27):    About MalaCards
    suppurative lymphadenitis    lymphadenitis    beckwith-wiedemann syndrome    sporadic breast cancer
    acute promyelocytic leukemia    lipodystrophy    oral squamous cell carcinoma    pituitary adenoma
    nasopharyngitis    infertility    chronic lymphocytic leukemia    insulin resistance
    osteosarcoma    adenoma    glioblastoma    squamous cell carcinoma
    acute myeloid leukemia    leukemia    breast cancer    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for WEE1:
    Suppurative lymphadenitis

    WEE1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for WEE1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beckwith-wiedemann syndrome 40.1 1 7842740 (1)
    cancer 18.8 7 19500427 (2), 20159553 (1), 11585773 (1), 15735666 (1)
    tumors 3.68 7 14760118 (1), 19288185 (1), 19887545 (1), 14726685 (1) (see all 7)
    leukemia 0 2 16619512 (1), 18351645 (1)
    cancer lung 0 2 14760118 (2)
    immunodeficiency 0 1 16968670 (1)

    Genetic Association Database (GAD): WEE1
    Human Genome Epidemiology (HuGE) Navigator: WEE1 (5 documents)
    Tumor Gene Database (TGDB): WEE1

    Export disorders for WEE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WEE1 gene, integrated from 9 sources (see all 222):
    (articles sorted by number of sources associating them with WEE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Wee1(+)-like gene in human cells. (PubMed id 1840647)1, 2, 3 Igarashi M.... Okayama H. (1991)
    2. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. (PubMed id 7743995)1, 2, 9 Watanabe N.... Hunter T. (1995)
    3. Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. (PubMed id 8428596)1, 2, 9 McGowan C.H. and Russell P. (1993)
    4. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). (PubMed id 11528126)1, 2, 9 Cichutek A.... Zabel B.U. (2001)
    5. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. (PubMed id 15070733)1, 2, 9 Watanabe N....Osada H. (2004)
    6. Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. (PubMed id 15837193)1, 2, 9 Squire C.J.... Baker E.N. (2005)
    7. Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. (PubMed id 22692537)1, 2 Visconti R.... Grieco D. (2012)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    10. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7465 HGNC: 12761 AceView: WEE1 Ensembl:ENSG00000166483 euGenes: HUgn7465
    ECgene: WEE1 Kegg: 7465 H-InvDB: WEE1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WEE1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WEE1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WEE1 gene:
    Search GeneIP for patents involving WEE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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