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WEE1 Gene

protein-coding   GIFtS: 70
GCID: GC11P009595

WEE1 G2 Checkpoint Kinase

(Previous names: wee1+ (S. pombe) homolog, WEE1 homolog (S. pombe))
  See WEE1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WEE1 G2 Checkpoint Kinase1 2     Wee1+ (S. Pombe) Homolog1
Wee1A Kinase2 3     WEE1A2
WEE1hu2 3     WEE1 Homolog2
EC 2.7.10.23 8     WEE1+ Homolog2
WEE1 Homolog (S. Pombe)1     Wee1-Like Protein Kinase2

External Ids:    HGNC: 127611   Entrez Gene: 74652   Ensembl: ENSG000001664837   OMIM: 1935255   UniProtKB: P302913   

Export aliases for WEE1 gene to outside databases

Previous GC identifers: GC11P010605 GC11P010164 GC11P009633 GC11P009558 GC11P009550 GC11P009266


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WEE1 Gene:
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein
kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to
coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically
activated CDC2 kinase. (provided by RefSeq, Jul 2008)

GeneCards Summary for WEE1 Gene:
WEE1 (WEE1 G2 checkpoint kinase) is a protein-coding gene. Diseases associated with WEE1 include suppurative lymphadenitis. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is WEE2.

UniProtKB/Swiss-Prot: WEE1_HUMAN, P30291
Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from
cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of
CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during
G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15'
and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases
at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably
due to its degradation

Gene Wiki entry for WEE1 (Wee1-like protein kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WEE1 gene promoter:
         p53   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): WEE1 promoter sequence
   Search Chromatin IP Primers for WEE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WEE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

WEE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WEE1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P009595:  view genomic region     (about GC identifiers)

Start:
9,595,228 bp from pter      End:
9,615,004 bp from pter
Size:
19,777 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WEE1_HUMAN, P30291 (See protein sequence)
Recommended Name: Wee1-like protein kinase  
Size: 646 amino acids; 71597 Da
Cofactor: Binds 2 magnesium ions per subunit
Selected PDB 3D structures from and Proteopedia for WEE1 (see all 8):
1X8B (3D)        2IN6 (3D)        2IO6 (3D)        2Z2W (3D)        3BI6 (3D)        3BIZ (3D)    
Secondary accessions: B3KVE1 D3DQV0
Alternative splicing: 2 isoforms:  P30291-1   P30291-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WEE1: NX_P30291

Explore proteomics data for WEE1 at MOPED

Post-translational modifications: 

  • Phosphorylated during M and G1 phases. Also autophosphorylated. Phosphorylation at Ser-642 by BRSK1 and BRSK2 in
    post-mitotic neurons, leads to down-regulate WEE1 activity in polarized neurons. Phosphorylated at Ser-53 and
    Ser-123 by PLK1 and CDK1, respectively, generating an signal for degradation that can be recognized by the
    SCF(BTRC) complex, leading to its ubiquitination and degradation at the onset of G2/M phase1
  • Dephosphorylated at Thr-239 by CTDP11
  • Ubiquitinated and degraded at the onset of G2/M phase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for WEE1 (P30291) (see all 5)
     WAEDDHM  RLDGCIYAIK  VEEGDSRFLANE  YAIKRSKKPLAGS 


    See WEE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137448.1  NP_003381.1  

    ENSEMBL proteins: 
     ENSP00000402084   ENSP00000299613   ENSP00000434446   ENSP00000434148   ENSP00000435945  
     ENSP00000432284  
    Reactome Protein details: P30291

    WEE1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    GenScript Custom Purified and Recombinant Proteins Services for WEE1
    Novus Biologicals WEE1 Proteins
    Novus Biologicals WEE1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WEE1

     
    Search eBioscience for Proteins for WEE1 

     
    antibodies-online proteins for WEE1 (7 products) 

     
    antibodies-online peptides for WEE1

    WEE1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals WEE1 Antibodies
    Abcam antibodies for WEE1
    Cloud-Clone Corp. Antibodies for WEE1
    ThermoFisher Antibodies for WEE1
    LSBio Antibodies in human, mouse, rat for WEE1
    antibodies-online antibodies for WEE1 (142 products) 

    WEE1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for WEE1
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    Cloud-Clone Corp. ELISAs for WEE1
    Cloud-Clone Corp. CLIAs for WEE1
    Search eBioscience for ELISAs for WEE1 
    antibodies-online kits for WEE1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: WEE1 homolog (S. pombe)
    WEE family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR017164 Wee1-like_protein_kinase

    Graphical View of Domain Structure for InterPro Entry P30291

    ProtoNet protein and cluster: P30291

    UniProtKB/Swiss-Prot: WEE1_HUMAN, P30291
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with WEE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WEE1_HUMAN, P30291
    Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from
    cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of
    CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during
    G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15'
    and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases
    at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably
    due to its degradation
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Synthesis is increased during S and G2 phases, presumably by an increase in transcription;
    activity is decreased by phosphorylation during m phase. Protein levels fall in M phase as a result of decreased
    synthesis combined with degradation. Activity seems to be negatively regulated by phosphorylation upon entry into
    mitosis, although N-terminal phosphorylation might also regulate the protein stability via protection from
    proteolysis or might regulate the subcellular location

         Genatlas biochemistry entry for WEE1:
    wee1 tyrosine kinase,yeast wee1 homolog,involved in cell cycle regulation

         Enzyme Number (IUBMB): EC 2.7.10.21 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity TAS7774574
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
         
    Find genes that share ontologies with WEE1           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for WEE1:
     Cell cycle / mitosis defect  Decreased cell number, increas  Decreased substrate adherent c  Gemcitabine induced cell-death 
     Increased cell death in HCC-19  Increased cell number in S  Increased number of mitotic ce  S arrest 
     Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Wee1 (no phenotypes)

    Find genes that share phenotypes with WEE1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WEE1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WEE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WEE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WEE1

    miRNA
    Products:
        
    miRTarBase miRNAs that target WEE1:
    hsa-mir-103a-3p (MIRT027225), hsa-mir-195-5p (MIRT000222), hsa-mir-92a-3p (MIRT048975), hsa-mir-130b-3p (MIRT020289), hsa-mir-106b-5p (MIRT005868), hsa-mir-424-5p (MIRT000659), hsa-mir-106a-5p (MIRT048347), hsa-mir-128-3p (MIRT006099), hsa-mir-20a-5p (MIRT005860), hsa-mir-372-3p (MIRT000057), hsa-mir-17-5p (MIRT005853), hsa-mir-10a-5p (MIRT025608), hsa-mir-16-5p (MIRT031934), hsa-mir-186-5p (MIRT045230), hsa-mir-221-3p (MIRT024171), hsa-mir-484 (MIRT041691), hsa-mir-130b-5p (MIRT038315), hsa-mir-155-5p (MIRT020929), hsa-mir-503-5p (MIRT000644), hsa-mir-19b-3p (MIRT031249)

    Block miRNA regulation of human, mouse, rat WEE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WEE1 (see all 45):
    hsa-miR-520e hsa-miR-302d hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-219-5p hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidWEE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WEE1
    Predesigned siRNA for gene silencing in human, mouse, rat WEE1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WEE1

    Clone
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    OriGene clones in human, mouse for WEE1 (see all 13)
    OriGene ORF clones in mouse, rat for WEE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WEE1 (NM_003390)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WEE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WEE1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for WEE1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WEE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WEE1_HUMAN, P30291: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8348613
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with WEE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WEE1 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    G1/S Transition0.81
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    4CDK-mediated phosphorylation and removal of Cdc6
    Cyclin E associated events during G1/S transition0.86
    S Phase0.78
    Cyclin A-Cdk2-associated events at S phase entry0.85
    Cell Cycle Checkpoints0.58
    5G2/M Checkpoints
    G2/M Checkpoints0.84
    G2/M DNA damage checkpoint0.00
    Chk1/Chk2(Cds1) mediated inactivation of Cyclin B-Cdk1 complex0.00


    Find genes that share SuperPaths with WEE1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WEE1
        14-3-3 and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation
    Molecular Mechanisms of Cancer
    Mitotic Roles of Polo Like Kinases

    2 Cell Signaling Technology (CST) Pathways for WEE1
        Cell Cycle / Checkpoint Control
    DNA Damage

    2 GeneGo (Thomson Reuters) Pathways for WEE1
        Cell cycle Role of SCF complex in cell cycle regulation
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5 BioSystems Pathways for WEE1
        Cell cycle
    G1 to S cell cycle control
    Integrated Breast Cancer Pathway
    RB in Cancer
    PLK1 signaling events

    Selected Reactome Pathways for WEE1 (see all 7)
        Factors involved in megakaryocyte development and platelet production
    Cyclin A:Cdk2-associated events at S phase entry
    Polo-like kinase mediated events
    Cyclin A/B1 associated events during G2/M transition
    G2/M DNA replication checkpoint


    1 Kegg Pathway  (Kegg details for WEE1):
        Cell cycle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WEE1: 
              Cell Cycle in human mouse rat
              Circadian Rhythms in human mouse rat
              Cancer PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WEE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WEE1 (P302911, 2, 3 ENSP000004020844) via UniProtKB, MINT, STRING, and/or I2D (see all 215)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 2, 3EBI-914695,EBI-347088 MINT-3294834 MINT-3294458 MINT-3295375 I2D: score=2 
    YWHABP319462, 3, ENSP000003001614MINT-16603 MINT-16602 MINT-50988 I2D: score=4 STRING: ENSP00000300161
    BTRCQ9Y2971, 3, ENSP000003592064EBI-914695,EBI-307461 I2D: score=4 STRING: ENSP00000359206
    FBXW11Q9UKB11, 3, ENSP000002650944EBI-914695,EBI-355189 I2D: score=4 STRING: ENSP00000265094
    SFNP319472, 3, ENSP000003409894MINT-3975741 I2D: score=2 STRING: ENSP00000340989
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0000278mitotic cell cycle TAS--
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with WEE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WEE1

    3 HMDB Compounds for WEE1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    6 DrugBank Compounds for WEE1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID-- --target--10592235
    4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione-- --target--10592235
    8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide-- --target--10592235
    9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE-- --target--10592235
    9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE-- --target--10592235
    N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE-- --target--10592235

    4 Novoseek inferred chemical compound relationships for WEE1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 53.8 24 14711880 (2), 7813446 (2), 1384126 (1), 15558017 (1) (see all 19)
    berberine 36.1 5 16619512 (4), 16440412 (1)
    curcumin 31 3 17201156 (1), 14534529 (1), 16596191 (1)
    oxygen 0 1 17201156 (1)



    Find genes that share compounds with WEE1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WEE1 gene (2 alternative transcripts): 
    NM_001143976.1  NM_003390.3  

    Unigene Cluster for WEE1:

    WEE1 homolog (S. pombe)
    Hs.249441  [show with all ESTs]
    Unigene Representative Sequence: BC070052
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450114(uc001mhs.3) ENST00000299613(uc001mht.3) ENST00000524549(uc001mhu.3)
    ENST00000524612 ENST00000530712 ENST00000530175 ENST00000532275 ENST00000527848

    miRNA
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    Block miRNA regulation of human, mouse, rat WEE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WEE1 (see all 45):
    hsa-miR-520e hsa-miR-302d hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-219-5p hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidWEE1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): WEE1 (NM_003390)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WEE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WEE1
    Primer
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    OriGene qPCR primer pairs and template standards for WEE1
    OriGene qSTAR qPCR primer pairs in human, mouse for WEE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WEE1
      QuantiTect SYBR Green Assays in human, mouse, rat WEE1
      QuantiFast Probe-based Assays in human, mouse, rat WEE1

    Additional mRNA sequence: 

    AK122837.1 BC051831.1 BC070052.1 U10564.1 X62048.1 

    8 DOTS entries:

    DT.315661  DT.95290127  DT.92432867  DT.95373536  DT.100036218  DT.100787721  DT.120680022  DT.120680029 

    Selected AceView cDNA sequences (see all 226):

    BE349189 AA916706 AI473778 AU125150 AW630943 AW949527 AI925639 AI589239 
    BQ024511 BX641032 AU116898 N34248 AA554199 AK122837 BU689831 CD517624 
    BU752866 AU126299 AU280199 AI799425 BC051831 BG611243 BQ009495 T63333 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    WEE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGCACTTG
    WEE1 Expression
    About this image


    WEE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Esophagus (Gastrointestinal Tract)
     
     Gall Bladder (Hepatobiliary System)
    WEE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WEE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249441
        Pathway & Disease-focused RT2 Profiler PCR Arrays including WEE1: 
              Cell Cycle in human mouse rat
              Circadian Rhythms in human mouse rat
              Cancer PathwayFinder in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WEE1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wee11 , 5 WEE 1 homolog 1 (S. pombe)1, 5 87.06(n)1
    90.68(a)1
      7 (57.70 cM)5
    223901  NM_009516.31  NP_033542.21 
     1101223505 
    chicken
    (Gallus gallus)
    Aves WEE11 WEE1 homolog (S. pombe) 77.05(n)
    81.31(a)
      423045  NM_001031181.2  NP_001026352.2 
    lizard
    (Anolis carolinensis)
    Reptilia WEE16
    WEE1 G2 checkpoint kinase
    74(a)
    1 ↔ 1
    1(64142847-64158598)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.173932 Xenopus laevis mRNA for Wee1B kinase, complete cds 80.09(n)    AB071983.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283462 Danio rerio cDNA clone IMAGE3815602, partial cds 77.65(n)    BC058071.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wee1 , 3 mitotic checkpoint protein tyrosine
    kinase3
    wee1
    43(a)3
    51.51(n)1
    49.42(a)1
      2 27C43
    339651  NM_001273238.11  NP_001260167.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWE16
    Protein kinase that regulates the G2/M transition ...
    13(a)
    1 → many
    X(76803-79262) YJL187C


    ENSEMBL Gene Tree for WEE1 (if available)
    TreeFam Gene Tree for WEE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WEE1 gene
    WEE22  PKMYT12  
    2 SIMAP similar genes for WEE1 using alignment to 7 protein entries:     WEE1_HUMAN (see all proteins):
    DKFZp686I18166    WEE2

    Find genes that share paralogs with WEE1           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for WEE1
    PGOHUM00000236992 PGOHUM00000237324 PGOHUM00000245419 PGOHUM00000245420 PGOHUM00000245423


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WEE1 (see all 368)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37638721,2
    C,F,A,H--9593427(-) ACATCG/AGTGGA 1 -- us2k124Minor allele frequency- A:0.32EA NS NA WA CSA 3839
    rs79406721,2
    C,F--9593574(+) ggccaG/Agcgcg 1 -- us2k16Minor allele frequency- A:0.16NA WA EA 364
    rs1901861011,2
    --9593608(+) CACTTC/TGGGAG 1 -- us2k10--------
    rs1453731771,2
    C--9593627(+) GGGCAC/GATCAC 1 -- us2k10--------
    rs1826376821,2
    --9593668(+) AACATA/GGTGAA 1 -- us2k10--------
    rs1873177221,2
    --9593781(+) AACCCA/GGGAGG 1 -- us2k10--------
    rs113703751,2
    C--9593857(+) TGTCGA/-AAAAA 1 -- us2k12Minor allele frequency- -:0.25NA CSA 4
    rs754099041,2
    C--9593870(+) CCAAAC/GCAAAC 1 -- us2k13Minor allele frequency- G:0.06NA WA 240
    rs618768301,2
    C--9594137(+) CGCTTC/GAACTC 1 -- us2k10--------
    rs37638711,2
    C--9594235(-) TTTTTA/TTTTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for WEE1 (9595228 - 9615004 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WEE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744094CNV Deletion23290073
    nsv7672CNV Insertion18451855
    nsv499766OTHER Inversion21111241
    nsv7215OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WEE1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 193525    OMIM disorders: --

    1 disease for WEE1:    
    About MalaCards
    suppurative lymphadenitis

    1 disease from the University of Copenhagen DISEASES database for WEE1:
    Suppurative lymphadenitis

    Find genes that share disorders with WEE1           About GenesLikeMe

    6 Novoseek inferred disease relationships for WEE1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beckwith-wiedemann syndrome 40.1 1 7842740 (1)
    cancer 18.8 7 19500427 (2), 20159553 (1), 11585773 (1), 15735666 (1)
    tumors 3.68 7 14760118 (1), 19288185 (1), 19887545 (1), 14726685 (1) (see all 7)
    leukemia 0 2 16619512 (1), 18351645 (1)
    cancer lung 0 2 14760118 (2)
    immunodeficiency 0 1 16968670 (1)

    Genetic Association Database (GAD): WEE1
    Human Genome Epidemiology (HuGE) Navigator: WEE1 (5 documents)
    Tumor Gene Database (TGDB): WEE1

    Export disorders for WEE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WEE1 gene, integrated from 10 sources (see all 224):
    (articles sorted by number of sources associating them with WEE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Wee1(+)-like gene in human cells. (PubMed id 1840647)1, 2, 3 Igarashi M.... Okayama H. (Nature 1991)
    2. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. (PubMed id 7743995)1, 2, 9 Watanabe N.... Hunter T. (EMBO J. 1995)
    3. Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. (PubMed id 8428596)1, 2, 9 McGowan C.H. and Russell P. (EMBO J. 1993)
    4. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). (PubMed id 11528126)1, 2, 9 Cichutek A.... Zabel B.U. (Cytogenet. Cell Genet. 2001)
    5. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. (PubMed id 15070733)1, 2, 9 Watanabe N.... Osada H. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. (PubMed id 15837193)1, 2, 9 Squire C.J.... Baker E.N. (Structure 2005)
    7. Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. (PubMed id 22692537)1, 2 Visconti R.... Grieco D. (Nat. Commun. 2012)
    8. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7465 HGNC: 12761 AceView: WEE1 Ensembl:ENSG00000166483 euGenes: HUgn7465
    ECgene: WEE1 Kegg: 7465 H-InvDB: WEE1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WEE1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WEE1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for WEE1 gene:
    Search GeneIP for patents involving WEE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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