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WDYHV1 Gene

protein-coding   GIFtS: 46
GCID: GC08P124428

WDYHV Motif Containing 1

(Previous name: chromosome 8 open reading frame 32)
(Previous symbol: C8orf32)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WDYHV Motif Containing 11 2     nt(Q)-amidase2
C8orf321 2 3     Protein N-Terminal Glutamine Amidohydrolase2
Protein NH2-Terminal Glutamine Deamidase2 3     EC 3.5.1.-3
N-Terminal Gln Amidase2 3     NTAQ13
WDYHV Motif-Containing Protein 12 3     Nt(Q)-amidase3
Chromosome 8 Open Reading Frame 321     

External Ids:    HGNC: 254901   Entrez Gene: 550932   Ensembl: ENSG000001567957   UniProtKB: Q96HA83   

Export aliases for WDYHV1 gene to outside databases

Previous GC identifers: GC08P124500 GC08P119754


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WDYHV1 Gene:
WDYHV1 (WDYHV motif containing 1) is a protein-coding gene. GO annotations related to this gene include protein-N-terminal glutamine amidohydrolase activity.

UniProtKB/Swiss-Prot: NTAQ1_HUMAN, Q96HA8
Function: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in
N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders
the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does
not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any
position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested
second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at
position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity)

Gene Wiki entry for WDYHV1 (C8orf32) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDYHV1 gene promoter:
         HFH-3   AML1a   RREB-1   FOXI1   CREB   HEN1   deltaCREB   FOXO4   ZIC2/Zic2   TGIF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDYHV1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

WDYHV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDYHV1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P124428:  view genomic region     (about GC identifiers)

Start:
124,428,965 bp from pter      End:
124,479,470 bp from pter
Size:
50,506 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NTAQ1_HUMAN, Q96HA8 (See protein sequence)
Recommended Name: Protein N-terminal glutamine amidohydrolase  
Size: 205 amino acids; 23680 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for WDYHV1:
3C9Q (3D)    
Secondary accessions: Q9NW95

Explore the universe of human proteins at neXtProt for WDYHV1: NX_Q96HA8

Explore proteomics data for WDYHV1 at MOPED


See WDYHV1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001269953.1  NP_001269956.1  NP_060494.1  

ENSEMBL proteins: 
 ENSP00000287387   ENSP00000430427   ENSP00000434252   ENSP00000430390   ENSP00000428615  
 ENSP00000429258  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR023128 Prot_N_Gln_amidohydro_ab_roll

Graphical View of Domain Structure for InterPro Entry Q96HA8

ProtoNet protein and cluster: Q96HA8

UniProtKB/Swiss-Prot: NTAQ1_HUMAN, Q96HA8
Similarity: Belongs to the NTAQ1 family


Find genes that share domains with WDYHV1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NTAQ1_HUMAN, Q96HA8
Function: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in
N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders
the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does
not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any
position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested
second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at
position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity)

     Enzyme Number (IUBMB): EC 3.5.1.-1

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI16189514
GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ----
GO:0070773protein-N-terminal glutamine amidohydrolase activity ISS--
     
Find genes that share ontologies with WDYHV1           About GenesLikeMe


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Wdyhv1):
 behavior/neurological 

Find genes that share phenotypes with WDYHV1           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDYHV1
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miRNA
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miRTarBase miRNAs that target WDYHV1:
hsa-mir-193b-3p (MIRT016567)

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2 qRT-PCR Assays for microRNAs that regulate WDYHV1:
hsa-miR-137 hsa-miR-548u
SwitchGear 3'UTR luciferase reporter plasmidWDYHV1 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NTAQ1_HUMAN, Q96HA8: Cytoplasm, cytosol (By similarity). Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
nucleus4
extracellular1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ISS--
GO:0005829cytosol ISS--

Find genes that share ontologies with WDYHV1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDYHV1
Interactions:

    Search GeneGlobe Interaction Network for WDYHV1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for WDYHV1 (Q96HA81, 2, 3 ENSP000002873874) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
InteractantInteraction Details
GeneCardExternal ID(s)
HPRT1P004921, 2, 3, ENSP000002985564EBI-741158,EBI-748210 MINT-67224 I2D: score=5 STRING: ENSP00000298556
HSD17B14Q9BPX11, 2, 3, ENSP000002632784EBI-741158,EBI-742664 MINT-66311 I2D: score=5 STRING: ENSP00000263278
JUPP149231, 2, 3, ENSP000003111134EBI-741158,EBI-702484 MINT-66801 I2D: score=5 STRING: ENSP00000311113
NME1P155311, 2, 3, ENSP000000130344EBI-741158,EBI-741141 MINT-66144 I2D: score=5 STRING: ENSP00000013034
SMN1Q166372, 3, ENSP000003700834MINT-68375 I2D: score=5 STRING: ENSP00000370083
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006464cellular protein modification process ISS--

Find genes that share ontologies with WDYHV1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for WDYHV1 (NTAQ1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for WDYHV1 gene (3 alternative transcripts): 
NM_001283024.1  NM_001283027.1  NM_018024.2  

Unigene Cluster for WDYHV1:

WDYHV motif containing 1
Hs.18029  [show with all ESTs]
Unigene Representative Sequence: AK293492
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000287387(uc003yqn.1) ENST00000523984(uc011lij.1) ENST00000524254
ENST00000522194 ENST00000517609 ENST00000519199 ENST00000523551 ENST00000523356
ENST00000518125
miRNA
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2 qRT-PCR Assays for microRNAs that regulate WDYHV1:
hsa-miR-137 hsa-miR-548u
SwitchGear 3'UTR luciferase reporter plasmidWDYHV1 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat WDYHV1
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Primer
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OriGene qPCR primer pairs and template standards for WDYHV1
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDYHV1
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  QuantiFast Probe-based Assays in human, mouse, rat WDYHV1

Additional mRNA sequence: 

AK001066.1 AK225643.1 AK293492.1 BC008781.2 

6 DOTS entries:

DT.449017  DT.100788165  DT.91763765  DT.91763760  DT.100788162  DT.95088716 

Selected AceView cDNA sequences (see all 136):

BE673522 AL538334 BM468411 NM_018024 BU632739 AI400386 CA313379 AU119047 
AI093302 AI271660 CR600640 BX119233 BI916514 AI422883 AI057379 AK001066 
BF437211 AI399793 AI871929 CB161316 BU556535 BE889754 AI918945 AI197936 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for WDYHV1    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1:                    -                                                               
SP2:                                            -                                       
SP3:                    -                       -                                       
SP4:                                                                                    
SP5:                                            -     -                                 


ECgene alternative splicing isoforms for WDYHV1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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WDYHV1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
WDYHV1 Expression
About this image

WDYHV1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

WDYHV1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.18029
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for WDYHV1 gene from Selected species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Wdyhv11 , 5 WDYHV motif containing 11, 5 83.01(n)1
84.8(a)1
  15 (24.38 cM)5
767731  NM_029734.11  NP_084010.11 
 581414365 
chicken
(Gallus gallus)
Aves WDYHV11 WDYHV motif containing 1 72.77(n)
67.82(a)
  420345  XM_418452.4  XP_418452.1 
lizard
(Anolis carolinensis)
Reptilia WDYHV16
WDYHV motif containing 1
63(a)
1 ↔ 1
4(6784754-6792246)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.127942 Transcribed sequence with weak similarity to protein more 74.67(n)    BX716305.1 
zebrafish
(Danio rerio)
Actinopterygii wdyhv11 WDYHV motif containing 1 67.51(n)
65.99(a)
  560935  NM_001044947.1  NP_001038412.1 
fruit fly
(Drosophila melanogaster)
Insecta tun1 tungus 50.09(n)
49.19(a)
  36743  NM_001259422.1  NP_001246351.1 
worm
(Caenorhabditis elegans)
Secernentea R06C7.61 R06C7.6 48.3(n)
39.2(a)
  187641  NM_059647.1  NP_492048.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G417601 AT2G41760 54.62(n)
39.35(a)
  818775  NM_129740.3  NP_565959.1 
rice
(Oryza sativa)
Liliopsida Os05g03879001 Os05g0387900 54.24(n)
48.52(a)
  4338665  NM_001061962.1  NP_001055427.1 


ENSEMBL Gene Tree for WDYHV1 (if available)
TreeFam Gene Tree for WDYHV1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for WDYHV1 gene
1 SIMAP similar gene for WDYHV1 using alignment to 5 protein entries:     NTAQ1_HUMAN (see all proteins):
C8orf32

Find genes that share paralogs with WDYHV1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for WDYHV1 (see all 753)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1874234201,2
--124426971(+) CTGGTC/TTTTGT 1 -- us2k10--------
rs1904547181,2
--124427015(+) AAACCC/TGCAAG 1 -- us2k10--------
rs1396169901,2
--124427302(+) CAAGAC/TTTAGA 1 -- us2k10--------
rs1495729861,2
--124427403(+) TGATGC/TTTAGT 1 -- us2k10--------
rs1442389301,2
--124427605(+) ACACAC/GGAACT 1 -- us2k10--------
rs1420211931,2
C--124427769(+) AAGAC-/TG    
   TAAAG
TGTAA
1 -- us2k10--------
rs1816681301,2
--124427811(+) TATTAA/GTATCA 1 -- us2k10--------
rs113065611,2
C,F--124427841(+) CACTA-/TTTTTT 1 -- us2k1 trp33Minor allele frequency- T:0.33NA CSA 6
rs1487099291,2
--124427978(+) TACAGA/GCGCGC 1 -- us2k10--------
rs1855577381,2
--124428024(+) GAGACA/GGAGTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for WDYHV1 (124428965 - 124479470 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for WDYHV1:    About this table    
Variant IDTypeSubtypePubMed ID
esv1157152CNV Insertion17803354
nsv831449CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing WDYHV1
DNA2.0 Custom Variant and Variant Library Synthesis for WDYHV1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for WDYHV1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with WDYHV1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  6. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
  7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55093 HGNC: 25490 AceView: FLJ10204 Ensembl:ENSG00000156795 euGenes: HUgn55093
ECgene: WDYHV1 H-InvDB: WDYHV1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for WDYHV1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for WDYHV1 gene:
Search GeneIP for patents involving WDYHV1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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