Aliases for WDYHV1 Gene
External Ids for WDYHV1 Gene
Previous Symbols for WDYHV1 Gene
GeneCards Summary for WDYHV1 Gene
WDYHV1 (WDYHV Motif Containing 1) is a Protein Coding gene. GO annotations related to this gene include protein-N-terminal glutamine amidohydrolase activity.
UniProtKB/Swiss-Prot for WDYHV1 Gene
Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity).