Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDYHV1 Gene

Aliases for WDYHV1 Gene

  • WDYHV Motif Containing 1 2 3
  • Protein NH2-Terminal Glutamine Deamidase 3 4
  • WDYHV Motif-Containing Protein 1 3 4
  • N-Terminal Gln Amidase 3 4
  • Nt(Q)-Amidase 3 4
  • C8orf32 3 4
  • Protein N-Terminal Glutamine Amidohydrolase 3
  • Chromosome 8 Open Reading Frame 32 2
  • EC 3.5.1.- 4
  • NTAQ1 4

External Ids for WDYHV1 Gene

Previous Symbols for WDYHV1 Gene

  • C8orf32

Summaries for WDYHV1 Gene

GeneCards Summary for WDYHV1 Gene

WDYHV1 (WDYHV Motif Containing 1) is a Protein Coding gene. GO annotations related to this gene include protein-N-terminal glutamine amidohydrolase activity.

UniProtKB/Swiss-Prot for WDYHV1 Gene

  • Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity).

Gene Wiki entry for WDYHV1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDYHV1 Gene

Genomics for WDYHV1 Gene

Genomic Location for WDYHV1 Gene

Start:
123,416,725 bp from pter
End:
123,467,230 bp from pter
Size:
50,506 bases
Orientation:
Plus strand

Genomic View for WDYHV1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDYHV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDYHV1 Gene

Regulatory Elements for WDYHV1 Gene

Proteins for WDYHV1 Gene

  • Protein details for WDYHV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HA8-NTAQ1_HUMAN
    Recommended name:
    Protein N-terminal glutamine amidohydrolase
    Protein Accession:
    Q96HA8
    Secondary Accessions:
    • B4DE68
    • Q9NW95

    Protein attributes for WDYHV1 Gene

    Size:
    205 amino acids
    Molecular mass:
    23680 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for WDYHV1 Gene

    Alternative splice isoforms for WDYHV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDYHV1 Gene

Proteomics data for WDYHV1 Gene at MOPED

Post-translational modifications for WDYHV1 Gene

No Post-translational modifications

Other Protein References for WDYHV1 Gene

No data available for DME Specific Peptides for WDYHV1 Gene

Domains for WDYHV1 Gene

Protein Domains for WDYHV1 Gene

Suggested Antigen Peptide Sequences for WDYHV1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HA8

UniProtKB/Swiss-Prot:

NTAQ1_HUMAN
Family:
  • Belongs to the NTAQ1 family.:
    • Q96HA8
genes like me logo Genes that share domains with WDYHV1: view

No data available for Gene Families for WDYHV1 Gene

Function for WDYHV1 Gene

Molecular function for WDYHV1 Gene

UniProtKB/Swiss-Prot Function: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity).

Enzyme Numbers (IUBMB) for WDYHV1 Gene

Gene Ontology (GO) - Molecular Function for WDYHV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides --
GO:0070773 protein-N-terminal glutamine amidohydrolase activity ISS --
genes like me logo Genes that share ontologies with WDYHV1: view

Phenotypes for WDYHV1 Gene

MGI mutant phenotypes for WDYHV1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with WDYHV1: view

miRNA for WDYHV1 Gene

miRTarBase miRNAs that target WDYHV1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for WDYHV1 Gene

Localization for WDYHV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDYHV1 Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDYHV1 Gene COMPARTMENTS Subcellular localization image for WDYHV1 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for WDYHV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with WDYHV1: view

Pathways for WDYHV1 Gene

SuperPathways for WDYHV1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDYHV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process ISS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with WDYHV1: view

No data available for Pathways by source for WDYHV1 Gene

Transcripts for WDYHV1 Gene

Unigene Clusters for WDYHV1 Gene

WDYHV motif containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDYHV1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: -
SP2: -
SP3: - -
SP4:
SP5: - -

Relevant External Links for WDYHV1 Gene

GeneLoc Exon Structure for
WDYHV1
ECgene alternative splicing isoforms for
WDYHV1

Expression for WDYHV1 Gene

mRNA expression in normal human tissues for WDYHV1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDYHV1 Gene

SOURCE GeneReport for Unigene cluster for WDYHV1 Gene Hs.18029

genes like me logo Genes that share expressions with WDYHV1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDYHV1 Gene

Orthologs for WDYHV1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDYHV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDYHV1 35
  • 99.02 (n)
  • 98.54 (a)
WDYHV1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDYHV1 35
  • 89.3 (n)
  • 92.51 (a)
WDYHV1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDYHV1 35
  • 91.5 (n)
  • 93.63 (a)
WDYHV1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdyhv1 35
  • 83.01 (n)
  • 84.8 (a)
Wdyhv1 16
Wdyhv1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDYHV1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDYHV1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdyhv1 35
  • 84.15 (n)
  • 86.76 (a)
chicken
(Gallus gallus)
Aves WDYHV1 35
  • 72.77 (n)
  • 67.82 (a)
WDYHV1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDYHV1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12794 35
wdyhv1 35
  • 66.49 (n)
  • 62.9 (a)
zebrafish
(Danio rerio)
Actinopterygii wdyhv1 35
  • 67.51 (n)
  • 65.99 (a)
wdyhv1 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NTAQ1_ANOGA 35
  • 55 (n)
  • 51.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta tun 35
  • 50.09 (n)
  • 49.19 (a)
tun 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R06C7.6 35
  • 48.3 (n)
  • 39.2 (a)
R06C7.6 36
  • 38 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G41760 35
  • 54.62 (n)
  • 39.35 (a)
rice
(Oryza sativa)
Liliopsida Os05g0387900 35
  • 54.24 (n)
  • 48.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for WDYHV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDYHV1 Gene

ENSEMBL:
Gene Tree for WDYHV1 (if available)
TreeFam:
Gene Tree for WDYHV1 (if available)

Paralogs for WDYHV1 Gene

Selected SIMAP similar genes for WDYHV1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDYHV1: view

No data available for Paralogs for WDYHV1 Gene

Variants for WDYHV1 Gene

Sequence variations from dbSNP and Humsavar for WDYHV1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1045270 -- 123,441,559(+) AGTGA(A/G)TACAA utr-variant-3-prime
rs1045284 -- 123,441,739(+) CTGTT(C/T)TGGAT utr-variant-3-prime
rs1045291 -- 123,441,767(+) CTACA(C/T)TGTAA utr-variant-3-prime
rs3765211 -- 123,437,945(+) CATGC(C/T)TGTGT intron-variant
rs3765212 -- 123,438,124(+) TTTAT(G/T)TGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDYHV1 Gene

Variant ID Type Subtype PubMed ID
nsv831449 CNV Loss 17160897
esv1157152 CNV Insertion 17803354

Relevant External Links for WDYHV1 Gene

HapMap Linkage Disequilibrium report
WDYHV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDYHV1 Gene

Disorders for WDYHV1 Gene

No disorders were found for WDYHV1 Gene.

No data available for UniProtKB/Swiss-Prot for WDYHV1 Gene

Publications for WDYHV1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3

Products for WDYHV1 Gene

Sources for WDYHV1 Gene

Back to Top

Content