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Aliases for WDTC1 Gene

Aliases for WDTC1 Gene

  • WD And Tetratricopeptide Repeats 1 2 3 5
  • DDB1 And CUL4 Associated Factor 9 2 3
  • WD And Tetratricopeptide Repeats Protein 1 3
  • Adipose Homolog (Drosophila) 2
  • Adipose Homolog 3
  • KIAA1037 4
  • DCAF9 3
  • ADP 3

External Ids for WDTC1 Gene

Previous GeneCards Identifiers for WDTC1 Gene

  • GC01P027165
  • GC01P027134
  • GC01P027433
  • GC01P027561
  • GC01P025818

Summaries for WDTC1 Gene

GeneCards Summary for WDTC1 Gene

WDTC1 (WD And Tetratricopeptide Repeats 1) is a Protein Coding gene. Diseases associated with WDTC1 include Hermansky-Pudlak Syndrome 2 and Qualitative Platelet Defect. GO annotations related to this gene include histone binding and enzyme inhibitor activity. An important paralog of this gene is DCAF6.

UniProtKB/Swiss-Prot for WDTC1 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDTC1 Gene

Genomics for WDTC1 Gene

Regulatory Elements for WDTC1 Gene

Enhancers for WDTC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G027135 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.3 -96.9 -96913 4.1 HDGF PKNOX1 ATF1 SIN3A ZNF766 ELK1 ZNF143 FOS ZNF263 ZNF592 ZDHHC18 WDTC1 LOC105376890 SLC9A1 TMEM222 ACTG1P20 RNU6-48P NUDC GPATCH3 FGR
GH01G027140 1.5 Ensembl ENCODE dbSUPER 14.7 -90.9 -90878 6.8 PKNOX1 SIN3A ZNF121 FOS JUNB REST ZNF592 ZNF579 MBD2 SMARCA4 WDTC1 LOC105376890 TMEM222 ACTG1P20 RNU6-48P NUDC GPATCH3 SLC9A1 LOC102723760 GC01P027051
GH01G026958 1.6 FANTOM5 Ensembl ENCODE 9.8 -273.7 -273674 3.9 FOXA2 MLX AGO1 ARID4B SIN3A DMAP1 ZNF48 ETS1 ZNF121 GLIS2 PIGV NR0B2 NUDC FAM46B GPATCH3 ENSG00000226698 SFN LOC105376890 WDTC1 ACTG1P20
GH01G026782 1.7 FANTOM5 ENCODE dbSUPER 8.9 -447.4 -447370 9.2 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ACTG1P20 HMGN2 RPS6KA1 PIGV ZDHHC18 ENSG00000226698 SFN MIR1976 GPATCH3 NUDC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDTC1 on UCSC Golden Path with GeneCards custom track

Promoters for WDTC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for WDTC1 Gene

27,234,516 bp from pter
27,308,633 bp from pter
74,118 bases
Plus strand

Genomic View for WDTC1 Gene

Genes around WDTC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDTC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDTC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDTC1 Gene

Proteins for WDTC1 Gene

  • Protein details for WDTC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD and tetratricopeptide repeats protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DPL5
    • Q5SSC5
    • Q9NV87
    • Q9UPW4

    Protein attributes for WDTC1 Gene

    677 amino acids
    Molecular mass:
    75920 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for WDTC1 Gene

    Alternative splice isoforms for WDTC1 Gene

neXtProt entry for WDTC1 Gene

Post-translational modifications for WDTC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDTC1 Gene

No data available for DME Specific Peptides for WDTC1 Gene

Domains & Families for WDTC1 Gene

Suggested Antigen Peptide Sequences for WDTC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDTC1: view

No data available for UniProtKB/Swiss-Prot for WDTC1 Gene

Function for WDTC1 Gene

Molecular function for WDTC1 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
GO:0005515 protein binding IPI 16964240
GO:0042393 histone binding IEA --
GO:0042826 histone deacetylase binding IEA --
genes like me logo Genes that share ontologies with WDTC1: view
genes like me logo Genes that share phenotypes with WDTC1: view

Animal Models for WDTC1 Gene

MGI Knock Outs for WDTC1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDTC1 Gene

Localization for WDTC1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDTC1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 4
plasma membrane 3
extracellular 3
cytoskeleton 3
endoplasmic reticulum 3
golgi apparatus 3
peroxisome 2
lysosome 2
endosome 2

Gene Ontology (GO) - Cellular Components for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with WDTC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDTC1 Gene

Pathways & Interactions for WDTC1 Gene

SuperPathways for WDTC1 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N5D0-WDTC1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006006 glucose metabolic process IEA --
GO:0008361 regulation of cell size IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with WDTC1: view

No data available for Pathways by source and SIGNOR curated interactions for WDTC1 Gene

Drugs & Compounds for WDTC1 Gene

No Compound Related Data Available

Transcripts for WDTC1 Gene

Unigene Clusters for WDTC1 Gene

WD and tetratricopeptide repeats 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDTC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a ·
SP1: -
SP2: -
SP3: - - - - -
SP5: -
SP6: -

ExUns: 16b

Relevant External Links for WDTC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDTC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDTC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDTC1 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for WDTC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.4), Retina (9.7), Testis (8.9), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDTC1 Gene

Protein tissue co-expression partners for WDTC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDTC1 Gene:


SOURCE GeneReport for Unigene cluster for WDTC1 Gene:


Evidence on tissue expression from TISSUES for WDTC1 Gene

  • Nervous system(4.9)
  • Muscle(4)
  • Blood(3.8)
  • Heart(3.7)
  • Liver(3.4)
  • Kidney(3.1)
  • Eye(2.9)
  • Pancreas(2.8)
  • Adrenal gland(2.7)
  • Intestine(2.6)
  • Lung(2.6)
  • Thyroid gland(2.5)
  • Skin(2.4)
  • Stomach(2.4)
  • Spleen(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with WDTC1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDTC1 Gene

Orthologs for WDTC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDTC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDTC1 34 35
  • 99.85 (n)
(Monodelphis domestica)
Mammalia WDTC1 35
  • 94 (a)
(Canis familiaris)
Mammalia WDTC1 34 35
  • 93.85 (n)
(Bos Taurus)
Mammalia WDTC1 34
  • 93.06 (n)
(Mus musculus)
Mammalia Wdtc1 34 16 35
  • 89.99 (n)
(Rattus norvegicus)
Mammalia Wdtc1 34
  • 89.89 (n)
(Ornithorhynchus anatinus)
Mammalia WDTC1 35
  • 69 (a)
(Gallus gallus)
Aves WDTC1 34 35
  • 81.67 (n)
(Anolis carolinensis)
Reptilia WDTC1 35
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdtc1 34
  • 73.05 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68614 34
(Danio rerio)
Actinopterygii wdtc1 34 35
  • 74.35 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003346 34
  • 52.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta adp 34 35
  • 49.97 (n)
(Caenorhabditis elegans)
Secernentea adpr-1 35
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10940 34
  • 44.69 (n)
(Oryza sativa)
Liliopsida Os03g0187300 34
  • 45.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8881 35
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8135 34
Species where no ortholog for WDTC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDTC1 Gene

Gene Tree for WDTC1 (if available)
Gene Tree for WDTC1 (if available)

Paralogs for WDTC1 Gene

Paralogs for WDTC1 Gene

genes like me logo Genes that share paralogs with WDTC1: view

Variants for WDTC1 Gene

Sequence variations from dbSNP and Humsavar for WDTC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000009528 -- 27,235,437(+) TGTGT(-/CC)CCACA intron-variant, upstream-variant-2KB
rs1000013999 -- 27,276,075(+) GGCCA(A/G)ATAGC intron-variant
rs1000023631 -- 27,304,254(+) TCATC(C/T)CCACC intron-variant
rs1000082223 -- 27,261,504(+) GCTTG(C/T)ATTCT intron-variant
rs1000087532 -- 27,283,849(+) CTCCC(A/C)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDTC1 Gene

Variant ID Type Subtype PubMed ID
esv2665584 CNV deletion 23128226
esv3585558 CNV loss 21293372
nsv1010793 CNV gain 25217958
nsv1119670 CNV deletion 24896259
nsv1122314 CNV deletion 24896259
nsv1133827 CNV deletion 24896259
nsv526051 CNV gain 19592680

Variation tolerance for WDTC1 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 29.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDTC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDTC1 Gene

Disorders for WDTC1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for WDTC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hermansky-pudlak syndrome 2
  • platelet storage pool deficiency
qualitative platelet defect
  • qualitative platelet deficiency nos
glycogen storage disease vii
  • glycogen storage disease type vii
commensal bacterial infectious disease
alveolar periostitis
  • alveolitis of jaw
- elite association - COSMIC cancer census association via MalaCards
Search WDTC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDTC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDTC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDTC1 Gene

Publications for WDTC1 Gene

  1. WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake. (PMID: 19238144) Lai C.Q. … OrdovA!s J.M. (Obesity (Silver Spring) 2009) 2 3 46 64
  2. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S. … Zheng N. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Control of triglyceride storage by a WD40/TPR-domain protein. (PMID: 12717455) HAoder T. … BrAPnner G. (EMBO Rep. 2003) 2 3 64

Products for WDTC1 Gene

Sources for WDTC1 Gene

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