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Aliases for WDTC1 Gene

Aliases for WDTC1 Gene

  • WD And Tetratricopeptide Repeats 1 2 3
  • DDB1 And CUL4 Associated Factor 9 2 3
  • WD And Tetratricopeptide Repeats Protein 1 3
  • Adipose Homolog (Drosophila) 2
  • Adipose Homolog 3
  • KIAA1037 4
  • DCAF9 3
  • ADP 3

External Ids for WDTC1 Gene

Summaries for WDTC1 Gene

GeneCards Summary for WDTC1 Gene

WDTC1 (WD And Tetratricopeptide Repeats 1) is a Protein Coding gene. GO annotations related to this gene include histone deacetylase binding and enzyme inhibitor activity. An important paralog of this gene is DCAF8.

UniProtKB/Swiss-Prot for WDTC1 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDTC1 Gene

Genomics for WDTC1 Gene

Genomic Location for WDTC1 Gene

27,234,516 bp from pter
27,308,633 bp from pter
74,118 bases
Plus strand

Genomic View for WDTC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDTC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDTC1 Gene

Regulatory Elements for WDTC1 Gene

Proteins for WDTC1 Gene

  • Protein details for WDTC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD and tetratricopeptide repeats protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DPL5
    • Q5SSC5
    • Q9NV87
    • Q9UPW4

    Protein attributes for WDTC1 Gene

    677 amino acids
    Molecular mass:
    75920 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for WDTC1 Gene

    Alternative splice isoforms for WDTC1 Gene

neXtProt entry for WDTC1 Gene

Proteomics data for WDTC1 Gene at MOPED

Post-translational modifications for WDTC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDTC1 Gene

No data available for DME Specific Peptides for WDTC1 Gene

Domains for WDTC1 Gene

Gene Families for WDTC1 Gene

  • WDR :WD repeat domain containing
  • TTC :Tetratricopeptide (TTC) repeat domain containing
  • DCAF :DDB1 and CUL4 associated factors


  • Contains 2 TPR repeats.:
    • Q8N5D0
  • Contains 7 WD repeats.:
    • Q8N5D0
genes like me logo Genes that share domains with WDTC1: view

Function for WDTC1 Gene

Molecular function for WDTC1 Gene

UniProtKB/Swiss-Prot Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
GO:0005515 protein binding IPI 16964240
GO:0042393 histone binding IEA --
GO:0042826 histone deacetylase binding IEA --
genes like me logo Genes that share ontologies with WDTC1: view
genes like me logo Genes that share phenotypes with WDTC1: view

miRNA for WDTC1 Gene

miRTarBase miRNAs that target WDTC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDTC1 Gene

Localization for WDTC1 Gene

Subcellular locations from

Jensen Localization Image for WDTC1 Gene COMPARTMENTS Subcellular localization image for WDTC1 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with WDTC1: view

Pathways for WDTC1 Gene

SuperPathways for WDTC1 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N5D0-WDTC1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006006 glucose metabolic process IEA --
GO:0008361 regulation of cell size IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with WDTC1: view

No data available for Pathways by source for WDTC1 Gene

Transcripts for WDTC1 Gene

Unigene Clusters for WDTC1 Gene

WD and tetratricopeptide repeats 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDTC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a ·
SP1: -
SP2: -
SP3: - - - - -
SP5: -
SP6: -

ExUns: 16b

Relevant External Links for WDTC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDTC1 Gene

mRNA expression in normal human tissues for WDTC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDTC1 Gene

This gene is overexpressed in Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDTC1 Gene

SOURCE GeneReport for Unigene cluster for WDTC1 Gene Hs.469154

genes like me logo Genes that share expressions with WDTC1: view

Orthologs for WDTC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDTC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDTC1 36
  • 99.85 (n)
  • 100 (a)
WDTC1 37
  • 100 (a)
(Bos Taurus)
Mammalia WDTC1 36
  • 93.06 (n)
  • 98.52 (a)
(Canis familiaris)
Mammalia WDTC1 36
  • 93.85 (n)
  • 98.82 (a)
WDTC1 37
  • 99 (a)
(Mus musculus)
Mammalia Wdtc1 36
  • 89.99 (n)
  • 96.75 (a)
Wdtc1 16
Wdtc1 37
  • 97 (a)
(Monodelphis domestica)
Mammalia WDTC1 37
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia WDTC1 37
  • 69 (a)
(Rattus norvegicus)
Mammalia Wdtc1 36
  • 89.89 (n)
  • 97.63 (a)
(Gallus gallus)
Aves WDTC1 36
  • 81.67 (n)
  • 94.04 (a)
WDTC1 37
  • 91 (a)
(Anolis carolinensis)
Reptilia WDTC1 37
  • 88 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68614 36
tropical clawed frog
(Silurana tropicalis)
Amphibia wdtc1 36
  • 73.05 (n)
  • 80.84 (a)
(Danio rerio)
Actinopterygii wdtc1 36
  • 74.35 (n)
  • 81.89 (a)
wdtc1 37
  • 81 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003346 36
  • 52.42 (n)
  • 43.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta adp 36
  • 49.97 (n)
  • 41.36 (a)
adp 37
  • 39 (a)
(Caenorhabditis elegans)
Secernentea adpr-1 37
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10940 36
  • 44.69 (n)
  • 37.56 (a)
(Oryza sativa)
Liliopsida Os03g0187300 36
  • 45.37 (n)
  • 39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8135 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8881 37
  • 49 (a)
Species with no ortholog for WDTC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDTC1 Gene

Gene Tree for WDTC1 (if available)
Gene Tree for WDTC1 (if available)

Paralogs for WDTC1 Gene

Paralogs for WDTC1 Gene

genes like me logo Genes that share paralogs with WDTC1: view

Variants for WDTC1 Gene

Sequence variations from dbSNP and Humsavar for WDTC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3813789 -- 27,296,581(+) CTTCA(A/C)GAGCT intron-variant
rs3813790 -- 27,296,637(+) TCCAT(A/G)GCTTG intron-variant
rs3813791 -- 27,306,634(+) TGCCC(C/G)CCCCC utr-variant-3-prime
rs3841357 -- 27,306,631(+) CCCCC(-/C)ATCTC utr-variant-3-prime
rs4078440 -- 27,301,718(+) ctggg(A/G)gagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDTC1 Gene

Variant ID Type Subtype PubMed ID
esv2665584 CNV Deletion 23128226
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294

Relevant External Links for WDTC1 Gene

HapMap Linkage Disequilibrium report

Disorders for WDTC1 Gene

Relevant External Links for WDTC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with WDTC1: view

No data available for UniProtKB/Swiss-Prot for WDTC1 Gene

Publications for WDTC1 Gene

  1. WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake. (PMID: 19238144) Lai C.Q. … OrdovA!s J.M. (Obesity (Silver Spring) 2009) 2 3 49
  2. Control of triglyceride storage by a WD40/TPR-domain protein. (PMID: 12717455) HAoder T. … BrAPnner G. (EMBO Rep. 2003) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S. … Zheng N. (Nature 2006) 3 4

Products for WDTC1 Gene

Sources for WDTC1 Gene

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