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Aliases for WDTC1 Gene

Aliases for WDTC1 Gene

  • WD And Tetratricopeptide Repeats 1 2 3
  • DDB1 And CUL4 Associated Factor 9 2 3
  • WD And Tetratricopeptide Repeats Protein 1 3
  • Adipose Homolog (Drosophila) 2
  • Adipose Homolog 3
  • KIAA1037 4
  • DCAF9 3
  • ADP 3

External Ids for WDTC1 Gene

Previous GeneCards Identifiers for WDTC1 Gene

  • GC01P027165
  • GC01P027134
  • GC01P027433
  • GC01P027561
  • GC01P025818

Summaries for WDTC1 Gene

GeneCards Summary for WDTC1 Gene

WDTC1 (WD And Tetratricopeptide Repeats 1) is a Protein Coding gene. GO annotations related to this gene include histone deacetylase binding and enzyme inhibitor activity. An important paralog of this gene is DCAF8.

UniProtKB/Swiss-Prot for WDTC1 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDTC1 Gene

Genomics for WDTC1 Gene

Regulatory Elements for WDTC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDTC1 Gene

Start:
27,234,516 bp from pter
End:
27,308,633 bp from pter
Size:
74,118 bases
Orientation:
Plus strand

Genomic View for WDTC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDTC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDTC1 Gene

Proteins for WDTC1 Gene

  • Protein details for WDTC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5D0-WDTC1_HUMAN
    Recommended name:
    WD and tetratricopeptide repeats protein 1
    Protein Accession:
    Q8N5D0
    Secondary Accessions:
    • D3DPL5
    • Q5SSC5
    • Q9NV87
    • Q9UPW4

    Protein attributes for WDTC1 Gene

    Size:
    677 amino acids
    Molecular mass:
    75920 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for WDTC1 Gene

    Alternative splice isoforms for WDTC1 Gene

neXtProt entry for WDTC1 Gene

Proteomics data for WDTC1 Gene at MOPED

Post-translational modifications for WDTC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDTC1 Gene

No data available for DME Specific Peptides for WDTC1 Gene

Domains for WDTC1 Gene

Gene Families for WDTC1 Gene

HGNC:
  • DCAF :DDB1 and CUL4 associated factors
  • TTC :Tetratricopeptide (TTC) repeat domain containing
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for WDTC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5D0

UniProtKB/Swiss-Prot:

WDTC1_HUMAN :
  • Q8N5D0
Similarity:
  • Contains 2 TPR repeats.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDTC1: view

Function for WDTC1 Gene

Molecular function for WDTC1 Gene

UniProtKB/Swiss-Prot Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IEA --
GO:0005515 protein binding IPI 16964240
GO:0042393 histone binding IEA --
GO:0042826 histone deacetylase binding IEA --
genes like me logo Genes that share ontologies with WDTC1: view
genes like me logo Genes that share phenotypes with WDTC1: view

Animal Model Products

CRISPR Products

miRNA for WDTC1 Gene

miRTarBase miRNAs that target WDTC1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDTC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDTC1 Gene

Localization for WDTC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDTC1 Gene COMPARTMENTS Subcellular localization image for WDTC1 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with WDTC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDTC1 Gene

Pathways for WDTC1 Gene

SuperPathways for WDTC1 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N5D0-WDTC1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for WDTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006006 glucose metabolic process IEA --
GO:0008361 regulation of cell size IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with WDTC1: view

No data available for Pathways by source for WDTC1 Gene

Transcripts for WDTC1 Gene

Unigene Clusters for WDTC1 Gene

WD and tetratricopeptide repeats 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDTC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDTC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a ·
SP1: -
SP2: -
SP3: - - - - -
SP4:
SP5: -
SP6: -
SP7:
SP8:

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for WDTC1 Gene

GeneLoc Exon Structure for
WDTC1
ECgene alternative splicing isoforms for
WDTC1

Expression for WDTC1 Gene

mRNA expression in normal human tissues for WDTC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDTC1 Gene

This gene is overexpressed in Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDTC1 Gene

SOURCE GeneReport for Unigene cluster for WDTC1 Gene Hs.469154

genes like me logo Genes that share expressions with WDTC1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for WDTC1 Gene

Orthologs for WDTC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDTC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDTC1 35
  • 99.85 (n)
  • 100 (a)
WDTC1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDTC1 35
  • 93.06 (n)
  • 98.52 (a)
dog
(Canis familiaris)
Mammalia WDTC1 35
  • 93.85 (n)
  • 98.82 (a)
WDTC1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdtc1 35
  • 89.99 (n)
  • 96.75 (a)
Wdtc1 16
Wdtc1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDTC1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDTC1 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdtc1 35
  • 89.89 (n)
  • 97.63 (a)
chicken
(Gallus gallus)
Aves WDTC1 35
  • 81.67 (n)
  • 94.04 (a)
WDTC1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDTC1 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68614 35
tropical clawed frog
(Silurana tropicalis)
Amphibia wdtc1 35
  • 73.05 (n)
  • 80.84 (a)
zebrafish
(Danio rerio)
Actinopterygii wdtc1 35
  • 74.35 (n)
  • 81.89 (a)
wdtc1 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003346 35
  • 52.42 (n)
  • 43.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta adp 35
  • 49.97 (n)
  • 41.36 (a)
adp 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea adpr-1 36
  • 33 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10940 35
  • 44.69 (n)
  • 37.56 (a)
rice
(Oryza sativa)
Liliopsida Os03g0187300 35
  • 45.37 (n)
  • 39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8135 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8881 36
  • 49 (a)
OneToOne
Species with no ortholog for WDTC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDTC1 Gene

ENSEMBL:
Gene Tree for WDTC1 (if available)
TreeFam:
Gene Tree for WDTC1 (if available)

Paralogs for WDTC1 Gene

Paralogs for WDTC1 Gene

genes like me logo Genes that share paralogs with WDTC1: view

Variants for WDTC1 Gene

Sequence variations from dbSNP and Humsavar for WDTC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3813789 -- 27,296,581(+) CTTCA(A/C)GAGCT intron-variant
rs3813790 -- 27,296,637(+) TCCAT(A/G)GCTTG intron-variant
rs3813791 -- 27,306,634(+) TGCCC(C/G)CCCCC utr-variant-3-prime
rs3841357 -- 27,306,631(+) CCCCC(-/C)ATCTC utr-variant-3-prime
rs4078440 -- 27,301,718(+) ctggg(A/G)gagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDTC1 Gene

Variant ID Type Subtype PubMed ID
esv2665584 CNV Deletion 23128226
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294

Relevant External Links for WDTC1 Gene

HapMap Linkage Disequilibrium report
WDTC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDTC1 Gene

Disorders for WDTC1 Gene

Relevant External Links for WDTC1

Genetic Association Database (GAD)
WDTC1
Human Genome Epidemiology (HuGE) Navigator
WDTC1
genes like me logo Genes that share disorders with WDTC1: view

No data available for UniProtKB/Swiss-Prot for WDTC1 Gene

Publications for WDTC1 Gene

  1. WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake. (PMID: 19238144) Lai C.Q. … OrdovA!s J.M. (Obesity (Silver Spring) 2009) 2 3 48
  2. Control of triglyceride storage by a WD40/TPR-domain protein. (PMID: 12717455) HAoder T. … BrAPnner G. (EMBO Rep. 2003) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S. … Zheng N. (Nature 2006) 3 4

Products for WDTC1 Gene

Sources for WDTC1 Gene

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