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WDTC1 Gene

protein-coding   GIFtS: 50
GCID: GC01P027561

WD And Tetratricopeptide Repeats 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD And Tetratricopeptide Repeats 11 2     DCAF92
DDB1 And CUL4 Associated Factor 91 2     Adipose Homolog2
Adipose Homolog (Drosophila)1     WD And Tetratricopeptide Repeats Protein 12
ADP2     KIAA10373

External Ids:    HGNC: 291751   Entrez Gene: 230382   Ensembl: ENSG000001427847   UniProtKB: Q8N5D03   

Export aliases for WDTC1 gene to outside databases

Previous GC identifers: GC01P027165 GC01P027134 GC01P027245 GC01P027433 GC01P025818


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WDTC1 Gene:
WDTC1 (WD and tetratricopeptide repeats 1) is a protein-coding gene. GO annotations related to this gene include enzyme inhibitor activity and histone deacetylase binding. An important paralog of this gene is ENSG00000258465.

UniProtKB/Swiss-Prot: WDTC1_HUMAN, Q8N5D0
Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDTC1 gene promoter:
         CREB   TBP   PPAR-gamma1   AP-1   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDTC1 promoter sequence
   Search Chromatin IP Primers for WDTC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDTC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3

WDTC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDTC1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P027561:  view genomic region     (about GC identifiers)

Start:
27,561,007 bp from pter      End:
27,635,110 bp from pter
Size:
74,104 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WDTC1_HUMAN, Q8N5D0 (See protein sequence)
Recommended Name: WD and tetratricopeptide repeats protein 1  
Size: 677 amino acids; 75920 Da
1 PDB 3D structure from and Proteopedia for WDTC1:
3I7N (3D)    
Secondary accessions: D3DPL5 Q5SSC5 Q9NV87 Q9UPW4
Alternative splicing: 6 isoforms:  Q8N5D0-1   Q8N5D0-2   Q8N5D0-3   Q8N5D0-4   Q8N5D0-5   Q8N5D0-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDTC1: NX_Q8N5D0

Explore proteomics data for WDTC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WDTC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001263181.1  NP_055838.2  

    ENSEMBL proteins: 
     ENSP00000355317   ENSP00000434578   ENSP00000435903   ENSP00000317971  

    WDTC1 Human Recombinant Protein Products:

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    Novus Biologicals WDTC1 Protein
    Novus Biologicals WDTC1 Lysates
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    Cloud-Clone Corp. Proteins for WDTC1

     
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    antibodies-online proteins for WDTC1 (4 products) 

     
    antibodies-online peptides for WDTC1

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    antibodies-online antibodies for WDTC1 (5 products) 

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    antibodies-online kits for WDTC1 (32 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DCAF: DDB1 and CUL4 associated factors
    WDR: WD repeat domain containing
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR001680 WD40_repeat
     IPR013105 TPR_2
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N5D0

    ProtoNet protein and cluster: Q8N5D0

    UniProtKB/Swiss-Prot: WDTC1_HUMAN, Q8N5D0
    Similarity: Contains 2 TPR repeats
    Similarity: Contains 7 WD repeats


    Find genes that share domains with WDTC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDTC1_HUMAN, Q8N5D0
    Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity IEA--
    GO:0005515protein binding IPI16964240
    GO:0042393histone binding IEA--
    GO:0042826histone deacetylase binding IEA--
         
    Find genes that share ontologies with WDTC1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for WDTC1:
     Decreased Wnt reporter activit  Decreased p24 protein expressi 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Wdtc1):
     adipose tissue  growth/size/body  homeostasis/metabolism  mortality/aging 

    Find genes that share phenotypes with WDTC1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WDTC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target WDTC1:
    hsa-mir-148a-3p (MIRT048038)

    Block miRNA regulation of human, mouse, rat WDTC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDTC1 (see all 86):
    hsa-miR-1321 hsa-miR-1914* hsa-miR-15a hsa-miR-128 hsa-miR-938 hsa-miR-509-3-5p hsa-miR-3612 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidWDTC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WDTC1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: WDTC1 (NM_015023)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDTC1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDTC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus3
    cytosol2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with WDTC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: WDTC1_HUMAN, Q8N5D0
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDTC1
    Interactions:

        GeneGlobe Interaction Network for WDTC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for WDTC1 (Q8N5D03 ENSP000003553174) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED23Q9ULK43, ENSP000003570474I2D: score=3 STRING: ENSP00000357047
    TADA2AO754783, ENSP000002253964I2D: score=1 STRING: ENSP00000225396
    DDB1Q165313, ENSP000003017644I2D: score=2 STRING: ENSP00000301764
    CUL4AQ136193, ENSP000003645894I2D: score=1 STRING: ENSP00000364589
    USP3Q9Y6I43, ENSP000003696814I2D: score=2 STRING: ENSP00000369681
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006006glucose metabolic process IEA--
    GO:0008361regulation of cell size IEA--
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with WDTC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDTC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDTC1 gene (2 alternative transcripts): 
    NM_001276252.1  NM_015023.4  

    Unigene Cluster for WDTC1:

    WD and tetratricopeptide repeats 1
    Hs.469154  [show with all ESTs]
    Unigene Representative Sequence: NM_001276252
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361771 ENST00000447062 ENST00000491239 ENST00000472249 ENST00000319394(uc009vst.2 uc001bnp.1 uc001bno.3 uc001bnq.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat WDTC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDTC1 (see all 86):
    hsa-miR-1321 hsa-miR-1914* hsa-miR-15a hsa-miR-128 hsa-miR-938 hsa-miR-509-3-5p hsa-miR-3612 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidWDTC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WDTC1
    Predesigned siRNA for gene silencing in human, mouse, rat WDTC1
    Clone
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    OriGene clones in human, mouse for WDTC1 (see all 7)
    OriGene ORF clones in mouse, rat for WDTC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WDTC1 (NM_015023)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDTC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDTC1
    Primer
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    OriGene qPCR primer pairs and template standards for WDTC1
    OriGene qSTAR qPCR primer pairs in human, mouse for WDTC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat WDTC1
      QuantiTect SYBR Green Assays in human, mouse, rat WDTC1
      QuantiFast Probe-based Assays in human, mouse, rat WDTC1

    Additional mRNA sequence: 

    AK001734.1 AK023101.1 AK023778.1 AK315564.1 BC032523.1 

    17 DOTS entries:

    DT.450261  DT.95134375  DT.100749634  DT.100749637  DT.102843772  DT.121427566  DT.100749635  DT.97814287 
    DT.121427578  DT.121427584  DT.121427586  DT.40107182  DT.87012714  DT.100749631  DT.100877814  DT.102843767 
    DT.99942089 

    Selected AceView cDNA sequences (see all 272):

    AI224521 BQ063584 BQ061888 BF932279 BQ063983 BF437110 BQ424546 AW366716 
    BQ643428 AU133289 BQ437673 CK902884 BQ058809 AI200837 BE252068 AU130694 
    BQ671974 BQ055748 BC032523 AL042884 AW576552 AI090491 BF222800 AI950673 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDTC1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a ·
    SP1:                    -                                                                                                                                       
    SP2:                                                                                                  -                                                         
    SP3:                                                              -     -     -     -                 -                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                  -                                                         

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for WDTC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDTC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAAAGCTT
    WDTC1 Expression
    About this image


    WDTC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Left Ventricle
     
     Testis (Reproductive System)
     
     Lymph (Hematopoietic System)
    WDTC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDTC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469154
        Custom PCR Arrays for WDTC1
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat WDTC1
    QuantiFast Probe-based Assays in human, mouse, rat WDTC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDTC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDTC1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdtc11 , 5 WD and tetratricopeptide repeats 11, 5 89.99(n)1
    96.75(a)1
      4 (66.25 cM)5
    2307961  NM_199306.41  NP_955010.11 
     1332924595 
    chicken
    (Gallus gallus)
    Aves WDTC11 WD and tetratricopeptide repeats 1 81.67(n)
    94.04(a)
      419581  XM_004947707.1  XP_004947764.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDTC16
    WD and tetratricopeptide repeats 1
    88(a)
    1 ↔ 1
    GL343488.1(499154-523793)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686142 hypothetical protein MGC68614 78.82(n)    BC060468.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI884877.12   -- 79.84(n)    BI884877.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta adp1 adipose 49.97(n)
    41.36(a)
      37073  NM_137452.3  NP_611296.2 
    worm
    (Caenorhabditis elegans)
    Secernentea adpr-16
    Protein ADPR-1 (adpr-1) mRNA, complete cds
    33(a)
    1 ↔ 1
    I(1610390-1619943) WBGene00044440
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G109401 AT5G10940 44.69(n)
    37.56(a)
      830961  NM_001203357.1  NP_001190286.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01873001 Os03g0187300 45.37(n)
    39(a)
      4331878  NM_001055743.1  NP_001049208.2 


    ENSEMBL Gene Tree for WDTC1 (if available)
    TreeFam Gene Tree for WDTC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDTC1 gene
    ENSG000002584652  DCAF82  DCAF8L22  DCAF62  DCAF8L12  

    Find genes that share paralogs with WDTC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDTC1 (see all 1263)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419880941,2
    C--27559009(+) TTCACC/TATGCT 2 -- us2k10--------
    rs1823079161,2
    --27559224(+) GCTGCA/GCCTCC 2 -- us2k10--------
    rs1157115501,2
    C,F--27559576(+) GATGAT/ACTCAA 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1143274781,2
    F--27559730(+) CTCCTC/GTAAAT 2 -- us2k12Minor allele frequency- G:0.03WA NA 238
    rs2004890041,2
    C--27559877(+) AAAAAA/CAAGCG 2 -- us2k10--------
    rs1866256161,2
    --27559882(+) CAAGCA/GACACA 2 -- us2k10--------
    rs112476281,2
    C,A,H--27559939(+) ACTGAG/AAGCGG 2 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs112476291,2
    C,A,H--27559992(+) gctcaG/Aactct 2 -- us2k16Minor allele frequency- A:0.00NS EA NA 424
    rs112476301,2
    A,H--27560009(+) aggcaG/Aatctg 2 -- us2k11Minor allele frequency- A:0.00NS 120
    rs120236211,2
    C,H--27560128(+) gctaaG/AagACT 2 -- us2k14Minor allele frequency- A:0.00NS EA 414

    HapMap Linkage Disequilibrium report for WDTC1 (27561007 - 27635110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WDTC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665584CNV Deletion23128226
    dgv203n71CNV Loss21882294
    nsv526051CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with WDTC1           About GenesLikeMe

    Genetic Association Database (GAD): WDTC1
    Human Genome Epidemiology (HuGE) Navigator: WDTC1 (3 documents)

    Export disorders for WDTC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDTC1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with WDTC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake. (PubMed id 19238144)1, 3, 4 Lai C.Q....OrdovA!s J.M. (Obesity (Silver Spring) 2009)
    2. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PubMed id 16964240)1, 2 Angers S.... Zheng N. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Control of triglyceride storage by a WD40/TPR-domain protein. (PubMed id 12717455)1, 3 HAoder T....BrAPnner G. (EMBO Rep. 2003)
    6. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    9. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23038 HGNC: 29175 AceView: WDTC1 Ensembl:ENSG00000142784 euGenes: HUgn23038
    ECgene: WDTC1 H-InvDB: WDTC1

    (According to HUGE)
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    HUGE: KIAA1037

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WDTC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDTC1 gene:
    Search GeneIP for patents involving WDTC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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