Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WDTC1 Gene

protein-coding GIFtS: 48
GCID: GC01P027561

WD and tetratricopeptide repeats 1

Explore 8 diseases affiliated with
WDTC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
WD And Tetratricopeptide Repeats 1¹ ²		Adipose Homolog²
ADP¹ ²		DDB1 And CUL4 Associated Factor 9²
DCAF9¹ ²		WD And Tetratricopeptide Repeats Protein 1²
KIAA1037¹ ³

External Ids:	HGNC: 29175¹	Entrez Gene: 23038²	Ensembl: ENSG00000142784⁷	UniProtKB: Q8N5D0³

Export aliases for WDTC1 gene to outside databases

Previous GC identifers: GC01P027165 GC01P027134 GC01P027245 GC01P027433 GC01P025818

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WDTC1 gene promoter:
CREB TBP PPAR-gamma1 AP-1 c-Jun PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WDTC1 promoter sequence

Search SABiosciences Chromatin IP Primers for WDTC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDTC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p35.3

WDTC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDTC1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P027561: view genomic region (about GC identifiers)

Start:	27,561,007 bp from pter	End:	27,635,110 bp from pter
Size:	74,104 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WDTC1_HUMAN, Q8N5D0 (See protein sequence)

Recommended Name: WD and tetratricopeptide repeats protein 1

Size: 677 amino acids; 75920 Da

1 PDB 3D structure from and Proteopedia for WDTC1:

3I7N (3D)

Secondary accessions: D3DPL5 Q5SSC5 Q9NV87 Q9UPW4

Alternative splicing: 6 isoforms: Q8N5D0-1 Q8N5D0-2 Q8N5D0-3 Q8N5D0-4 Q8N5D0-5 Q8N5D0-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDTC1: NX_Q8N5D0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N5D0

WDTC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001263181.1 NP_055838.2

ENSEMBL proteins:

ENSP00000355317 ENSP00000434578 ENSP00000435903 ENSP00000317971

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: WDTC1 OriGene Protein Over-expression Lysate: WDTC1 OriGene Custom Protein Services for WDTC1
	GenScript Custom Purified and Recombinant Proteins Services for WDTC1
	Novus Biologicals WDTC1 Protein Novus Biologicals WDTC1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for WDTC1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	IEA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

WDTC1 for ontologies About GeneDecksing

WDTC1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for WDTC1
	GenScript Custom Superior Antibodies Services for WDTC1
	Novus Biologicals WDTC1 Antibodies
	Search for Antibodies for WDTC1 at Abcam
	Uscn Antibodies for WDTC1
	ThermoFisher Antibodies for WDTC1

Assay Products for WDTC1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for WDTC1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for WDTC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WDTC1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR011990 TPR-like_helical

IPR001680 WD40_repeat

IPR013105 TPR_2

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q8N5D0

ProtoNet protein and cluster: Q8N5D0

UniProtKB/Swiss-Prot: WDTC1_HUMAN, Q8N5D0

Similarity: Contains 2 TPR repeats

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone: WDTC1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WDTC1
		8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate WDTC1 (see all 86):
		hsa-miR-1321 hsa-miR-1914* hsa-miR-15a hsa-miR-128 hsa-miR-938 hsa-miR-509-3-5p hsa-miR-3612 hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: WDTC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDTC1 (see all 7) OriGene shRNA RFP: WDTC1 OriGene siRNA: WDTC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDTC1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for WDTC1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDTC1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDTC1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: WDTC1 (NM_015023)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDTC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDTC1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for WDTC1
		Search LifeMap BioReagents cell lines for WDTC1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDTC1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004857	enzyme inhibitor activity	IEA	--
GO:0005515	protein binding	IPI	16964240
GO:0042393	histone binding	IEA	--
GO:0042826	histone deacetylase binding	IEA	--

WDTC1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for WDTC1:

Decreased Wnt reporter activit

Decreased p24 protein expressi

Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Wdtc1):

adipose tissue

growth/size

homeostasis/metabolism

mortality/aging

WDTC1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for WDTC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/10 Interacting proteins for WDTC1 (Q8N5D0³ ENSP00000355317⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MED23	Q9ULK4³, ENSP00000357047⁴	I2D: score=3 STRING: ENSP00000357047
TADA2A	O75478³, ENSP00000225396⁴	I2D: score=1 STRING: ENSP00000225396
DDB1	Q16531³, ENSP00000301764⁴	I2D: score=2 STRING: ENSP00000301764
CUL4A	Q13619³, ENSP00000364589⁴	I2D: score=1 STRING: ENSP00000364589
USP3	Q9Y6I4³, ENSP00000369681⁴	I2D: score=2 STRING: ENSP00000369681

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001701	in utero embryonic development	IEA	--
GO:0006006	glucose metabolic process	IEA	--
GO:0008361	regulation of cell size	IEA	--
GO:0032869	cellular response to insulin stimulus	IEA	--

WDTC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WDTC1
Search CenterWatch for drugs/clinical trials and news about WDTC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WDTC1 gene (2 alternative transcripts):

NM_001276252.1 NM_015023.4

Unigene Cluster for WDTC1:

WD and tetratricopeptide repeats 1

Hs.469154 [show with all ESTs]

Unigene Representative Sequence: AB028960

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361771 ENST00000447062 ENST00000491239 ENST00000472249 ENST00000319394(uc009vst.2 uc001bnp.1 uc001bno.3 uc001bnq.3)

miRNA Products:		OriGene 3'-UTR Clone: WDTC1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WDTC1
		8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate WDTC1 (see all 86):
		hsa-miR-1321 hsa-miR-1914* hsa-miR-15a hsa-miR-128 hsa-miR-938 hsa-miR-509-3-5p hsa-miR-3612 hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: WDTC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDTC1 (see all 7) OriGene shRNA RFP: WDTC1 OriGene siRNA: WDTC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDTC1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDTC1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDTC1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: WDTC1 (NM_015023)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDTC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDTC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDTC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat WDTC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDTC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDTC1

Additional cDNA sequence:

AB028960.1 AK001734.1 AK023101.1 AK023778.1 AK315564.1 BC032523.1

17 DOTS entries:

DT.450261 DT.95134375 DT.100749634 DT.100749637 DT.102843772 DT.121427566 DT.100749635 DT.97814287

DT.121427578 DT.121427584 DT.121427586 DT.40107182 DT.87012714 DT.100749631 DT.100877814 DT.102843767

DT.99942089

24/272 AceView cDNA sequences (see all 272):

AI911533 AU133289 AI200837 AL705424 BQ643428 CK902884 BM696106 BC032523

AV698989 AI625097 AL042892 BQ056582 BF932279 AI090491 AB028960 BE252068

AL042893 AI247978 BQ063983 BQ643006 AI536937 BQ054989 BQ065354 CD513294

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WDTC1 (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b	·	13c	^	14a	·	14b	·	14c	^	15a	·	15b	^	16a	·
SP1:							-
SP2:																																	-
SP3:																					-		-		-		-						-
SP4:
SP5:																																	-

ExUns:	16b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for WDTC1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WDTC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAAAAGCTT

About this image

WDTC1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Left Ventricle

Heart

Right Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See WDTC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDTC1

SOURCE GeneReport for Unigene cluster: Hs.469154

SABiosciences Custom PCR Arrays for WDTC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDTC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat WDTC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDTC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDTC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDTC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDTC1 gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	WDTC1¹	WD and tetratricopeptide repeats 1	81.89(n) 94.33(a)		419581 XM_417728.3 XP_417728.2
lizard (Anolis carolinensis)	Reptilia	WDTC1⁶	--	90(a)	1 ↔ 1	GL343488.1(504420-520034)
African clawed frog (Xenopus laevis)	Amphibia	MGC68614²	hypothetical protein MGC68614	78.82(n)		BC060468.1
zebrafish (Danio rerio)	Actinopterygii	BI884877.1²	--	79.84(n)		BI884877.1
fruit fly (Drosophila melanogaster)	Insecta	adp¹	adipose	50.82(n) 41.75(a)		37073 NM_137452.3 NP_611296.2
worm (Caenorhabditis elegans)	Secernentea	adpr-1⁶	ADiPose (Drosophila obesity gene) Related family m...	30(a)	1 ↔ 1	I(1610392-1619945)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G10940¹	WD and tetratricopeptide repeats protein 1	44.69(n) 39.52(a)		830961 NM_121132.4 NP_568242.1
rice (Oryza sativa)	Liliopsida	Os03g0187300¹	hypothetical protein	46.38(n) 42.75(a)		4331878 NM_001055743.1 NP_001049208.2

ENSEMBL Gene Tree for WDTC1 (if available)
TreeFam Gene Tree for WDTC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WDTC1 gene

DCAF5² ENSG00000258465² DCAF8² DCAF8L2² DCAF6² DCAF8L1²

WDTC1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141988094^1,2		--	27559009(+)	`TTCACC/TATGCT`	1	--	us2k¹		0	--	--	--	--
rs182307916^1,2		--	27559224(+)	`GCTGCA/GCCTCC`	1	--	us2k¹		0	--	--	--	--
rs115711550^1,2	F,	--	27559576(+)	`GATGAT/ACTCAA`	1	--	us2k¹		1		WA	118
rs114327478^1,2	F,	--	27559730(+)	`CTCCTC/GTAAAT`	1	--	us2k¹		2		WA NA	238
rs71010341^1,2	C	--	27559849(+)	`ATTGG-/AAAAAA AAAAA`	1	--	us2k¹		1		NA	2
rs186625616^1,2		--	27559882(+)	`CAAGCA/GACACA`	1	--	us2k¹		0	--	--	--	--
rs11247628^1,2	C,A,H	--	27559939(+)	`ACTGAG/AAGCGG`	1	--	us2k¹		4		NS EA	418
rs11247629^1,2	C,A,H	--	27559992(+)	`GCTCAG/AACTCT`	1	--	us2k¹		6		NS EA NA	424
rs11247630^1,2	A,H	--	27560009(+)	`aggcaG/Aatctg`	1	--	us2k¹		1		NS	120
rs12023621^1,2	C,H	--	27560128(+)	`GCTAAG/AAGACT`	1	--	us2k¹		4		NS EA	414

HapMap Linkage Disequilibrium report for WDTC1 (27561007 - 27635110 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WDTC1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDTC1

DNA2.0 Custom Variant and Variant Library Synthesis for WDTC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WDTC1 for disorders About GeneDecksing

8 diseases for WDTC1: About MalaCards

hypersensitivity reaction type ii disease diphtheria hemorrhagic disease hypercholesterolemia

cholera hyperglycemia pertussis obesity

Human Genome Epidemiology (HuGE) Navigator: WDTC1 (3 documents)

Export disorders for WDTC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WDTC1 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with WDTC1)

Utopia: connect your pdf to the dynamic
world of online information

WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake. (PubMed id 19238144)^{1, 3} Lai C.Q....OrdovA!s J.M. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Control of triglyceride storage by a WD40/TPR-domain protein. (PubMed id 12717455)^{1, 3} Hader T....Bronner G. (2003)
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{1, 2} Kikuno R....Ohara O. (1999)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. (PubMed id 20508642)¹ Krebs A.R....Tora L. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23038	HGNC: 29175	AceView: WDTC1	Ensembl:ENSG00000142784	euGenes: HUgn23038
ECgene: WDTC1	H-InvDB: WDTC1

(According to HUGE)
About This Section

HUGE: KIAA1037

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WDTC1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WDTC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WDTC1 gene:
Search GeneIP for patents involving WDTC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for WDTC1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDTC1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDTC1
	OriGene Protein Over-expression Lysate for WDTC1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for WDTC1		OriGene 3'-UTR Clone for WDTC1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDTC1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDTC1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for WDTC1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for WDTC1		OriGene Custom Protein Services for WDTC1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDTC1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDTC1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDTC1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDTC1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDTC1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDTC1

	GenScript Custom Purified and Recombinant Proteins Services for WDTC1		GenScript cDNA clones with any tag delivered in your preferred vector for WDTC1
	GenScript Custom Assay Services for WDTC1		GenScript Custom Superior Antibodies Services for WDTC1
	GenScript Custom overexpressing Cell Line Services for WDTC1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in WDTC1 promoter
	Search Chromatin IP Primers for WDTC1
	RT² qPCR Primer Assay in human, mouse / rat WDTC1
	GNC Network for WDTC1
	SABiosciences Custom PCR Arrays for WDTC1

Search Tocris compounds for WDTC1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	WDTC1 antibodies
	WDTC1 proteins
	WDTC1 lysates

	Search for Antibodies for WDTC1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for WDTC1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

WDTC1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for WDTC1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDTC1

	SwitchGear 3'UTR luciferase reporter plasmids for WDTC1
	SwitchGear Promoter luciferase reporter plasmids for WDTC1

ThermoFisher Antibodies for WDTC1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDTC1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes WDTC1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

WDTC1 Gene

WD and tetratricopeptide repeats 1

Aliases
for WDTC1 gene

Summaries
for WDTC1 gene

Genomic Views
for WDTC1 gene

Proteins
for WDTC1 gene

Protein Domains /
Families
for WDTC1 gene

Function
for WDTC1 gene

Pathways & Interactions
for WDTC1 gene

Drugs & Compounds
for WDTC1 gene

Transcripts
for WDTC1 gene

Expression
for WDTC1 gene

Orthologs
for WDTC1 gene

Paralogs
for WDTC1 gene

Genomic Variants
for WDTC1 gene

Disorders / Diseases
for WDTC1 gene

Publications
for WDTC1 gene

External Searches for WDTC1 gene

Genome Databases showing WDTC1 gene

Other Databases showing WDTC1 gene

Specialized Databases showing WDTC1 gene

Intellectual Property
for WDTC1 gene

Products
for WDTC1 gene

View Random Gene

Advanced Search

Export list of displayed genes

WDTC1 Gene

WD and tetratricopeptide repeats 1

Aliasesfor WDTC1 gene

Summariesfor WDTC1 gene

Genomic Viewsfor WDTC1 gene

Proteinsfor WDTC1 gene

Protein Domains /Familiesfor WDTC1 gene

Functionfor WDTC1 gene

Pathways & Interactionsfor WDTC1 gene

Drugs & Compoundsfor WDTC1 gene

Transcriptsfor WDTC1 gene

Expression for WDTC1 gene

Orthologsfor WDTC1 gene

Paralogsfor WDTC1 gene

Genomic Variantsfor WDTC1 gene

Disorders / Diseasesfor WDTC1 gene

Publicationsfor WDTC1 gene

External Searches for WDTC1 gene

Genome Databases showing WDTC1 gene

Other Databases showing WDTC1 gene

Specialized Databases showing WDTC1 gene

Intellectual Propertyfor WDTC1 gene

Productsfor WDTC1 gene

View Random Gene

Aliases
for WDTC1 gene

Summaries
for WDTC1 gene

Genomic Views
for WDTC1 gene

Proteins
for WDTC1 gene

Protein Domains /
Families
for WDTC1 gene

Function
for WDTC1 gene

Pathways & Interactions
for WDTC1 gene

Drugs & Compounds
for WDTC1 gene

Transcripts
for WDTC1 gene

Expression
for WDTC1 gene

Orthologs
for WDTC1 gene

Paralogs
for WDTC1 gene

Genomic Variants
for WDTC1 gene

Disorders / Diseases
for WDTC1 gene

Publications
for WDTC1 gene

Intellectual Property
for WDTC1 gene

Products
for WDTC1 gene