Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDSUB1 Gene

Aliases for WDSUB1 Gene

  • WD Repeat, Sterile Alpha Motif And U-Box Domain Containing 1 2 3
  • WD Repeat, SAM And U-Box Domain Containing 1 2 3
  • WD Repeat And SAM Domain Containing 1 2 3
  • WDSAM1 3 4
  • WD Repeat, SAM And U-Box Domain-Containing Protein 1 3
  • 2610014F08Rik 3
  • UBOX6 3

External Ids for WDSUB1 Gene

Previous HGNC Symbols for WDSUB1 Gene

  • WDSAM1

Previous GeneCards Identifiers for WDSUB1 Gene

  • GC02M159918
  • GC02M159800
  • GC02M160092
  • GC02M151978

Summaries for WDSUB1 Gene

GeneCards Summary for WDSUB1 Gene

WDSUB1 (WD Repeat, Sterile Alpha Motif And U-Box Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TAF5L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDSUB1 Gene

Genomics for WDSUB1 Gene

Regulatory Elements for WDSUB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDSUB1 Gene

Start:
159,235,793 bp from pter
End:
159,286,799 bp from pter
Size:
51,007 bases
Orientation:
Minus strand

Genomic View for WDSUB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDSUB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDSUB1 Gene

Proteins for WDSUB1 Gene

  • Protein details for WDSUB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9V3-WSDU1_HUMAN
    Recommended name:
    WD repeat, SAM and U-box domain-containing protein 1
    Protein Accession:
    Q8N9V3
    Secondary Accessions:
    • Q53TI9
    • Q8N6N8

    Protein attributes for WDSUB1 Gene

    Size:
    476 amino acids
    Molecular mass:
    52817 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDSUB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDSUB1 Gene

Proteomics data for WDSUB1 Gene at MOPED

Post-translational modifications for WDSUB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDSUB1 Gene

Antibody Products

No data available for DME Specific Peptides for WDSUB1 Gene

Domains for WDSUB1 Gene

Gene Families for WDSUB1 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing
  • UBOX :U-box domain containing
  • WDR :WD repeat domain containing

Graphical View of Domain Structure for InterPro Entry

Q8N9V3

UniProtKB/Swiss-Prot:

WSDU1_HUMAN :
  • Q8N9V3
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 1 U-box domain.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDSUB1: view

Function for WDSUB1 Gene

Gene Ontology (GO) - Molecular Function for WDSUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with WDSUB1: view

Phenotypes for WDSUB1 Gene

GenomeRNAi human phenotypes for WDSUB1:
genes like me logo Genes that share phenotypes with WDSUB1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDSUB1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WDSUB1 Gene

Localization for WDSUB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDSUB1 Gene COMPARTMENTS Subcellular localization image for WDSUB1 gene
Compartment Confidence
cytosol 3
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDSUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
genes like me logo Genes that share ontologies with WDSUB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDSUB1 Gene

Pathways for WDSUB1 Gene

SuperPathways for WDSUB1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for WDSUB1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352820%0d%0a9606.ENSP00000276326%0d%0a
Selected Interacting proteins: ENSP00000352820 for WDSUB1 Gene via STRING

Symbol External ID(s) Details
FBXO25

Gene Ontology (GO) - Biological Process for WDSUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with WDSUB1: view

No data available for Pathways by source for WDSUB1 Gene

Transcripts for WDSUB1 Gene

Unigene Clusters for WDSUB1 Gene

WD repeat, sterile alpha motif and U-box domain containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDSUB1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDSUB1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: -
SP3: - - - - - - -
SP4: - - -
SP5: - -

Relevant External Links for WDSUB1 Gene

GeneLoc Exon Structure for
WDSUB1
ECgene alternative splicing isoforms for
WDSUB1

Expression for WDSUB1 Gene

mRNA expression in normal human tissues for WDSUB1 Gene

Protein differential expression in normal tissues for WDSUB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.2), Monocytes (9.9), and Blymphocyte (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for WDSUB1 Gene

SOURCE GeneReport for Unigene cluster for WDSUB1 Gene Hs.20848

genes like me logo Genes that share expressions with WDSUB1: view

Expression partners for WDSUB1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDSUB1 Gene

Orthologs for WDSUB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDSUB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDSUB1 35
  • 90.32 (n)
  • 88.84 (a)
WDSUB1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDSUB1 35
  • 90.48 (n)
  • 92.23 (a)
WDSUB1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdsub1 35
  • 80.1 (n)
  • 82.49 (a)
Wdsub1 16
Wdsub1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDSUB1 35
  • 99.65 (n)
  • 99.16 (a)
WDSUB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdsub1 35
  • 80.53 (n)
  • 84.03 (a)
oppossum
(Monodelphis domestica)
Mammalia WDSUB1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDSUB1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDSUB1 35
  • 76.26 (n)
  • 74.79 (a)
WDSUB1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDSUB1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdsub1 35
  • 63.99 (n)
  • 61.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13287 35
zebrafish
(Danio rerio)
Actinopterygii wdsub1 35
  • 59.53 (n)
  • 58.67 (a)
wdsub1 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5875 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005577 35
  • 44.18 (n)
  • 35.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta can 36
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-5 36
  • 8 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 36
  • 9 (a)
OneToMany
Species with no ortholog for WDSUB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDSUB1 Gene

ENSEMBL:
Gene Tree for WDSUB1 (if available)
TreeFam:
Gene Tree for WDSUB1 (if available)

Paralogs for WDSUB1 Gene

Paralogs for WDSUB1 Gene

Selected SIMAP similar genes for WDSUB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDSUB1: view

Variants for WDSUB1 Gene

Sequence variations from dbSNP and Humsavar for WDSUB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs52848 -- 159,281,227(+) TAAAA(G/T)TGTTA intron-variant
rs52849 -- 159,281,484(+) TTGCA(A/G)TACAA intron-variant
rs174262 -- 159,286,274(-) ACATT(C/T)CTGGT intron-variant
rs174263 -- 159,282,370(+) TGTAT(C/T)TTTAG intron-variant
rs174264 -- 159,279,826(+) TATGC(A/G)GACAC missense, reference, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for WDSUB1 Gene

Variant ID Type Subtype PubMed ID
esv259475 OTHER Complex 20981092
esv259940 OTHER Complex 20981092
nsv214147 CNV Insertion 16902084
esv1058134 CNV Insertion 17803354
esv3946 CNV Deletion 18987735
esv2661160 CNV Deletion 23128226
esv2721031 CNV Deletion 23290073
esv2667062 CNV Deletion 23128226
nsv820981 CNV Deletion 20802225
nsv821770 CNV Loss 20364138
esv27856 CNV Gain+Loss 19812545
esv33532 CNV Loss 17666407
esv1504441 CNV Insertion 17803354
esv1008546 CNV Insertion 20482838
nsv875335 CNV Loss 21882294
dgv4350n71 CNV Loss 21882294
nsv508175 CNV Loss 20534489
esv2245332 CNV Deletion 18987734
esv2721032 CNV Deletion 23290073
esv1748759 CNV Deletion 17803354
esv2675744 CNV Deletion 23128226

Relevant External Links for WDSUB1 Gene

HapMap Linkage Disequilibrium report
WDSUB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDSUB1 Gene

Disorders for WDSUB1 Gene

No disorders were found for WDSUB1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for WDSUB1 Gene

Publications for WDSUB1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira F.R. … Gomes M.D. (J. Biol. Chem. 2013) 3

Products for WDSUB1 Gene

Sources for WDSUB1 Gene

Back to Top

Content