Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDSUB1 Gene

Aliases for WDSUB1 Gene

  • WD Repeat, Sterile Alpha Motif And U-Box Domain Containing 1 2 3 5
  • WD Repeat, SAM And U-Box Domain Containing 1 2 3
  • WD Repeat And SAM Domain Containing 1 2 3
  • WDSAM1 3 4
  • 2610014F08Rik 3
  • UBOX6 3

External Ids for WDSUB1 Gene

Previous HGNC Symbols for WDSUB1 Gene

  • WDSAM1

Previous GeneCards Identifiers for WDSUB1 Gene

  • GC02M159918
  • GC02M159800
  • GC02M160092
  • GC02M151978

Summaries for WDSUB1 Gene

GeneCards Summary for WDSUB1 Gene

WDSUB1 (WD Repeat, Sterile Alpha Motif And U-Box Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is WSB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDSUB1 Gene

Genomics for WDSUB1 Gene

Regulatory Elements for WDSUB1 Gene

Enhancers for WDSUB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDSUB1 on UCSC Golden Path with GeneCards custom track

Promoters for WDSUB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDSUB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDSUB1 Gene

159,235,793 bp from pter
159,286,799 bp from pter
51,007 bases
Minus strand

Genomic View for WDSUB1 Gene

Genes around WDSUB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDSUB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDSUB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDSUB1 Gene

Proteins for WDSUB1 Gene

  • Protein details for WDSUB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat, SAM and U-box domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q53TI9
    • Q8N6N8

    Protein attributes for WDSUB1 Gene

    476 amino acids
    Molecular mass:
    52817 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDSUB1 Gene


neXtProt entry for WDSUB1 Gene

Proteomics data for WDSUB1 Gene at MOPED

Post-translational modifications for WDSUB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDSUB1 Gene

No data available for DME Specific Peptides for WDSUB1 Gene

Domains & Families for WDSUB1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 7 WD repeats.
  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 1 U-box domain.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDSUB1: view

Function for WDSUB1 Gene

Gene Ontology (GO) - Molecular Function for WDSUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
genes like me logo Genes that share ontologies with WDSUB1: view
genes like me logo Genes that share phenotypes with WDSUB1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WDSUB1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDSUB1 Gene

Localization for WDSUB1 Gene

Subcellular locations from

Jensen Localization Image for WDSUB1 Gene COMPARTMENTS Subcellular localization image for WDSUB1 gene
Compartment Confidence
cytosol 3
extracellular 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDSUB1 Gene

Pathways & Interactions for WDSUB1 Gene

SuperPathways for WDSUB1 Gene

No Data Available

Interacting Proteins for WDSUB1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000352820 for WDSUB1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for WDSUB1 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDSUB1 Gene

Drugs & Compounds for WDSUB1 Gene

No Compound Related Data Available

Transcripts for WDSUB1 Gene

Unigene Clusters for WDSUB1 Gene

WD repeat, sterile alpha motif and U-box domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDSUB1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP2: -
SP3: - - - - - - -
SP4: - - -
SP5: - -

Relevant External Links for WDSUB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDSUB1 Gene

mRNA expression in normal human tissues for WDSUB1 Gene

Protein differential expression in normal tissues from HIPED for WDSUB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.2), Monocytes (9.9), and Blymphocyte (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDSUB1 Gene

SOURCE GeneReport for Unigene cluster for WDSUB1 Gene Hs.20848

genes like me logo Genes that share expression patterns with WDSUB1: view

Protein tissue co-expression partners for WDSUB1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDSUB1 Gene

Orthologs for WDSUB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDSUB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDSUB1 35
  • 90.32 (n)
  • 88.84 (a)
  • 88 (a)
(Canis familiaris)
Mammalia WDSUB1 35
  • 90.48 (n)
  • 92.23 (a)
  • 92 (a)
(Mus musculus)
Mammalia Wdsub1 35
  • 80.1 (n)
  • 82.49 (a)
Wdsub1 16
Wdsub1 36
  • 82 (a)
(Pan troglodytes)
Mammalia WDSUB1 35
  • 99.65 (n)
  • 99.16 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Wdsub1 35
  • 80.53 (n)
  • 84.03 (a)
(Monodelphis domestica)
Mammalia WDSUB1 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia WDSUB1 36
  • 83 (a)
(Gallus gallus)
Aves WDSUB1 35
  • 76.26 (n)
  • 74.79 (a)
  • 73 (a)
(Anolis carolinensis)
Reptilia WDSUB1 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdsub1 35
  • 63.99 (n)
  • 61.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13287 35
(Danio rerio)
Actinopterygii wdsub1 35
  • 59.53 (n)
  • 58.67 (a)
wdsub1 36
  • 56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5875 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005577 35
  • 44.18 (n)
  • 35.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta can 36
  • 7 (a)
(Caenorhabditis elegans)
Secernentea taf-5 36
  • 8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 36
  • 9 (a)
Species with no ortholog for WDSUB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDSUB1 Gene

Gene Tree for WDSUB1 (if available)
Gene Tree for WDSUB1 (if available)

Paralogs for WDSUB1 Gene

Paralogs for WDSUB1 Gene

(5) SIMAP similar genes for WDSUB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDSUB1: view

Variants for WDSUB1 Gene

Sequence variations from dbSNP and Humsavar for WDSUB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs16843852 - 159,275,578(+) AAATT(A/G/T)TGACT nc-transcript-variant, reference, missense
rs17852677 - 159,275,555(+) GATAT(C/G)GGTAA nc-transcript-variant, reference, missense
rs7591849 - 159,256,370(+) TGTGC(A/G/T)CCTTG nc-transcript-variant, reference, missense
rs375471 -- 159,272,711(+) AAATA(C/T)TTTCT intron-variant
rs455862 -- 159,282,323(+) aagta(C/T)ctggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDSUB1 Gene

Variant ID Type Subtype PubMed ID
esv259475 OTHER Complex 20981092
esv259940 OTHER Complex 20981092
nsv214147 CNV Insertion 16902084
esv1058134 CNV Insertion 17803354
esv3946 CNV Deletion 18987735
esv2661160 CNV Deletion 23128226
esv2721031 CNV Deletion 23290073
esv2667062 CNV Deletion 23128226
nsv820981 CNV Deletion 20802225
nsv821770 CNV Loss 20364138
esv27856 CNV Gain+Loss 19812545
esv33532 CNV Loss 17666407
esv1504441 CNV Insertion 17803354
esv1008546 CNV Insertion 20482838
nsv875335 CNV Loss 21882294
dgv4350n71 CNV Loss 21882294
nsv508175 CNV Loss 20534489
esv2245332 CNV Deletion 18987734
esv2721032 CNV Deletion 23290073
esv1748759 CNV Deletion 17803354
esv2675744 CNV Deletion 23128226

Variation tolerance for WDSUB1 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.90; 97.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDSUB1 Gene

Disorders for WDSUB1 Gene

Relevant External Links for WDSUB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDSUB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDSUB1 Gene

Publications for WDSUB1 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira F.R. … Gomes M.D. (J. Biol. Chem. 2013) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for WDSUB1 Gene

Sources for WDSUB1 Gene