WDSUB1 Gene
protein-coding GIFtS: 44
GCID: GC02M160092
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|
WD repeat, sterile alpha motif and U-box domain containing...(Previous names: WD repeat and SAM domain containing 1, WD repeat, SAM and...)
(Previous symbol: WDSAM1)
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Aliases
for WDSUB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat, Sterile Alpha Motif And U-Box Domain Containing 11 2 | | WD Repeat, SAM And U-Box Domain Containing 11 2 | | WDSAM11 2 3 | | FLJ361751 | | UBOX61 2 | | 2610014F08Rik2 | | WD Repeat And SAM Domain Containing 11 2 | | WD Repeat, SAM And U-Box Domain-Containing Protein 12 |
Export aliases for WDSUB1 gene to outside databasesPrevious GC identifers: GC02M159918 GC02M159800 GC02M151978 |
Summaries
for WDSUB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDSUB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDSUB1 gene promoter:
NF-YB CBF-A CBF-B CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDSUB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDSUB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q24.2 Ensembl cytogenetic band: 2q24.2 HGNC cytogenetic band: 2q24.2WDSUB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M160092: view genomic region
(about GC identifiers)
Start:
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160,092,304 bp from pter |
End:
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160,143,310 bp from pter |
Size:
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51,007 bases |
Orientation:
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minus strand |
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Proteins
for WDSUB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WSDU1_HUMAN, Q8N9V3 (See
protein sequence)Recommended Name: WD repeat, SAM and U-box domain-containing protein 1 Size: 476 amino acids; 52817 Da
Secondary accessions: Q53TI9 Q8N6N8Alternative splicing: 2 isoforms: Q8N9V3-1 Q8N9V3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDSUB1: NX_Q8N9V3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N9V3
WDSUB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001121684.1 NP_001121685.1 NP_689741.2
ENSEMBL proteins: ENSP00000352820 ENSP00000350866 ENSP00000376545 ENSP00000387078 ENSP00000386891
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000151 | ubiquitin ligase complex |
IEA | -- |
WDSUB1 for ontologies About GeneDecksing
WDSUB1 Antibody Products:
Assay Products for WDSUB1: |
Protein
Domains /
Families
for WDSUB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDSUB1 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q8N9V3ProtoNet protein and cluster: Q8N9V3 4 Blocks protein families: IPB001632 Beta G-protein (transducin) signature IPB001660 Sterile alpha motif SAM IPB003613 Zn-finger IPB011510 Sterile alpha motif homology 2
UniProtKB/Swiss-Prot: WSDU1_HUMAN, Q8N9V3Similarity: Contains 1 SAM (sterile alpha motif) domainSimilarity: Contains 1 U-box domainSimilarity: Contains 7 WD repeats |
Function
for WDSUB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDSUB1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDSUB1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for WDSUB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDSUB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDSUB1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
IEA | -- |
WDSUB1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for WDSUB1:
Animal Models:
Mouse knock-out Wdsub1tm1Lex for WDSUB1
1 MGI phenotypic allele  for Wdsub1 (no phenotypes)
WDSUB1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for WDSUB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDSUB1
|
Drugs & Compounds
for WDSUB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDSUB1
Search CenterWatch for drugs/clinical trials and news about WDSUB1 / WSDU1
|
Transcripts
for WDSUB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDSUB1 gene (3 alternative transcripts): NM_001128212.1 NM_001128213.1 NM_152528.2 Unigene Cluster for WDSUB1: WD repeat, sterile alpha motif and U-box domain containing 1 Hs.20848 [show with all ESTs]Unigene Representative Sequence: NM_0011282135 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359774(uc002ual.4 uc010foo.3) ENST00000358147 ENST00000392796(uc002uaj.4)
ENST00000409990(uc002uak.4) ENST00000409124
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDSUB1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDSUB1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): WDSUB1 (NM_001128212) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDSUB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDSUB1 |
Additional cDNA sequence: AK093494.1 AK129983.1 BC029520.1 6 DOTS entries: DT.412010 DT.100012673 DT.92430032 DT.412011 DT.100735497 DT.100666820 24/92 AceView cDNA sequences (see all 92): BU729598 CR607851 BE669639 AA492441 AI635762 BE501611 CB240898 CR619104 BF110272 BF110027 BG769613 BG217163 AA353945 BC029520 BE675766 BE048489 AX748164 BG186973 AV703043 BF432932 BG562985 AW137678 CB987596 BM543484
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for WDSUB1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDSUB1
|
Expression
for WDSUB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDSUB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTTACTAT
About this image
See WDSUB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDSUB1
SOURCE GeneReport for Unigene cluster: Hs.20848
SABiosciences Expression via Pathway-Focused PCR Array including WDSUB1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDSUB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDSUB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDSUB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDSUB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDSUB1 |
Orthologs
for WDSUB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WDSUB1 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for WDSUB1 (if available)
TreeFam Gene Tree for WDSUB1 (if available) |
Paralogs
for WDSUB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDSUB1 gene
- POC1B2 WDR832 WDR52 ATG16L12 WDR882 SNRNP402 WDR5B2 KATNB12
- PAFAH1B12 PRPF42 DAW12 WDR382 ATG16L22 POC1A2
5 SIMAP similar genes for WDSUB1 using alignment to 3 protein entries: WSDU1_HUMAN (see all proteins):GNB1 WSB1 POC1B PF20 WDR38
WDSUB1 for paralogs About GeneDecksing
|
Genomic Variants
for WDSUB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDSUB1 (160092304 - 160143310 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for WDSUB1
4 CNVs: 78840 90101 43566 63223
2 Indels: 45884 11160 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDSUB1 |
|
Disorders
/ Diseases
for WDSUB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WDSUB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDSUB1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDSUB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for WDSUB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDSUB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDSUB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDSUB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDSUB1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDSUB1 gene:
Search GeneIP for patents involving WDSUB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDSUB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for WDSUB1 | | OriGene Custom Protein Services for WDSUB1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDSUB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDSUB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDSUB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDSUB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDSUB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDSUB1 |
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 | | | WDSUB1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDSUB1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDSUB1 |
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