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Aliases for WDR97 Gene

Aliases for WDR97 Gene

  • WD Repeat Domain 97 2 3 5
  • KIAA1875 2 3 4
  • WD Repeat-Containing Protein 97 3

External Ids for WDR97 Gene

Previous HGNC Symbols for WDR97 Gene

  • KIAA1875

Summaries for WDR97 Gene

Entrez Gene Summary for WDR97 Gene

  • The function and protein-coding potential of this gene is unknown. The exon combination is based on AB058778.1 for which two possible open reading frames can be predicted (with start codons at nucleotide 26 or 2614). The position of the first ORF stop codon is consistent with a prediction of nonsense-mediated decay. Given the observation of the first ORF and its length, a predicted translation of the second ORF is inconsistent with the translation leaky scanning theory. Therefore, this gene is represented as a non-protein-coding transcript. [provided by RefSeq, Oct 2008]

GeneCards Summary for WDR97 Gene

WDR97 (WD Repeat Domain 97) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR97 Gene

Genomics for WDR97 Gene

Regulatory Elements for WDR97 Gene

Enhancers for WDR97 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around WDR97 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR97 Gene

Chromosome:
8
Start:
144,107,726 bp from pter
End:
144,118,315 bp from pter
Size:
10,590 bases
Orientation:
Plus strand

Genomic View for WDR97 Gene

Genes around WDR97 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR97 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR97 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR97 Gene

Proteins for WDR97 Gene

  • Protein details for WDR97 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NE52-WDR97_HUMAN
    Recommended name:
    WD repeat-containing protein 97
    Protein Accession:
    A6NE52
    Secondary Accessions:
    • Q96JF2

    Protein attributes for WDR97 Gene

    Size:
    1622 amino acids
    Molecular mass:
    180307 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47504.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR97 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR97 Gene

Post-translational modifications for WDR97 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR97 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR97 Gene

Domains & Families for WDR97 Gene

Gene Families for WDR97 Gene

Protein Domains for WDR97 Gene

Suggested Antigen Peptide Sequences for WDR97 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NE52

UniProtKB/Swiss-Prot:

WDR97_HUMAN :
  • Contains 6 WD repeats.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR97: view

Function for WDR97 Gene

Gene Ontology (GO) - Molecular Function for WDR97 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000386 contributes_to second spliceosomal transesterification activity IBA --
genes like me logo Genes that share ontologies with WDR97: view
genes like me logo Genes that share phenotypes with WDR97: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR97 Gene

Localization for WDR97 Gene

Gene Ontology (GO) - Cellular Components for WDR97 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071013 catalytic step 2 spliceosome IBA --
genes like me logo Genes that share ontologies with WDR97: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for WDR97 Gene

Pathways & Interactions for WDR97 Gene

SuperPathways for WDR97 Gene

No Data Available

Interacting Proteins for WDR97 Gene

Selected Interacting proteins: A6NE52-WDR97_HUMAN for WDR97 Gene via IID

Symbol External ID(s) Details
FBXW7

Gene Ontology (GO) - Biological Process for WDR97 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000350 generation of catalytic spliceosome for second transesterification step IBA --
genes like me logo Genes that share ontologies with WDR97: view

No data available for Pathways by source and SIGNOR curated interactions for WDR97 Gene

Drugs & Compounds for WDR97 Gene

No Compound Related Data Available

Transcripts for WDR97 Gene

mRNA/cDNA for WDR97 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for WDR97 Gene

No ASD Table

Relevant External Links for WDR97 Gene

GeneLoc Exon Structure for
WDR97
ECgene alternative splicing isoforms for
WDR97

Expression for WDR97 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR97 Gene:

WDR97
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for WDR97 Gene

Orthologs for WDR97 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR97 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 69 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia KIAA1875 35
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
cow
(Bos Taurus)
Mammalia KIAA1875 35
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA1875 35
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1875 35
  • 36 (a)
OneToOne
Species where no ortholog for WDR97 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WDR97 Gene

ENSEMBL:
Gene Tree for WDR97 (if available)
TreeFam:
Gene Tree for WDR97 (if available)

Paralogs for WDR97 Gene

No data available for Paralogs for WDR97 Gene

Variants for WDR97 Gene

Sequence variations from dbSNP and Humsavar for WDR97 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs4977196 - 144,108,511(-) AAGCC(C/G)GACAG nc-transcript-variant
rs34324679 - 144,109,615(+) CTCCA(A/C)GTGCA nc-transcript-variant
rs13250446 - 144,109,944(+) TCTCG(A/G)AGGCG nc-transcript-variant
rs1132230 -- 144,116,298(+) ACCGG(A/C/G)CTGGT nc-transcript-variant
rs4075064 -- 144,113,593(-) GCCGG(C/T)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR97 Gene

Variant ID Type Subtype PubMed ID
dgv12431n54 CNV loss 21841781
dgv12433n54 CNV gain 21841781
dgv906n27 CNV loss 19166990
esv2759651 CNV gain 17122850
esv29971 CNV loss 17803354
esv3619121 CNV loss 21293372
esv3619122 CNV gain 21293372
nsv1025071 CNV gain 25217958
nsv1030888 CNV gain 25217958
nsv428208 CNV gain 18775914
nsv466014 CNV loss 19166990
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612914 CNV loss 21841781
nsv612915 CNV loss 21841781
nsv6448 CNV insertion 18451855
nsv824802 CNV gain 20364138
nsv824803 CNV gain 20364138
nsv950015 CNV deletion 24416366

Variation tolerance for WDR97 Gene

Gene Damage Index Score: 5.26; 70.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR97 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR97

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR97 Gene

Disorders for WDR97 Gene

Relevant External Links for WDR97

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR97
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR97

No disorders were found for WDR97 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR97 Gene

Publications for WDR97 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 65
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 65
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 65

Products for WDR97 Gene

Sources for WDR97 Gene

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