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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WDR96 Gene

protein-coding GIFtS: 40
GCID: GC10M105889

WD repeat domain 96

(Previous name: chromosome 10 open reading frame 79 )
(Previous symbol: C10orf79)

Explore 2 diseases affiliated with
WDR96 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
WD Repeat Domain 96¹ ²		FLJ36006¹
C10orf79¹ ² ³		Chromosome 10 Open Reading Frame 79¹
BA373N18.2¹		WD Repeat-Containing Protein 96²
FLJ22944¹		WD Repeat-Containing Protein C10orf79²

External Ids:	HGNC: 26684¹	Entrez Gene: 80217²	Ensembl: ENSG00000197748⁷	UniProtKB: Q8NDM7³

Export aliases for WDR96 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for WDR96
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for WDR96

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR96

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1 Ensembl cytogenetic band: 10q25.1 HGNC cytogenetic band: 10q25.1

WDR96 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR96 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M105889: view genomic region (about GC identifiers)

Start:	105,889,646 bp from pter	End:	105,992,120 bp from pter
Size:	102,475 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WDR96_HUMAN, Q8NDM7 (See protein sequence)

Recommended Name: WD repeat-containing protein 96

Size: 1665 amino acids; 191984 Da

Sequence caution: Sequence=BAC04133.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=CAB66835.1; Type=Frameshift; Positions=34, 625, 849, 1232, 1348, 1351, 1460, 1473, 1524, 1577;

Sequence=CAI17220.1; Type=Erroneous gene model prediction; Sequence=CAI17221.1; Type=Erroneous gene model prediction;

Sequence=CAI40457.1; Type=Erroneous gene model prediction;

Secondary accessions: Q8N9Z8 Q8NE17 Q9H085 Q9H5W3

Alternative splicing: 5 isoforms: Q8NDM7-1 Q8NDM7-2 Q8NDM7-3 Q8NDM7-4 Q8NDM7-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR96: NX_Q8NDM7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NDM7

WDR96 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_079421.5

ENSEMBL proteins:

ENSP00000394274 ENSP00000391364 ENSP00000278064 ENSP00000358734 ENSP00000358733

ENSP00000349568 ENSP00000400289

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	Uscn ELISAs and CLIAs for WDR96

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WDR96 for domains About GeneDecksing

3 InterPro domains/families:

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q8NDM7

ProtoNet protein and cluster: Q8NDM7

UniProtKB/Swiss-Prot: WDR96_HUMAN, Q8NDM7

Similarity: Contains 9 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for WDR96:

Increased homologous recombina

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for WDR96

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR96

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for WDR96

1 Interacting protein for WDR96 (Q8NDM7³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAE	P62258³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WDR96
Search CenterWatch for drugs/clinical trials and news about WDR96

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WDR96 gene:

NM_025145.5

Unigene Cluster for WDR96:

WD repeat domain 96

Hs.288927 [show with all ESTs]

Unigene Representative Sequence: NM_025145

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000457071 ENST00000434629 ENST00000479392 ENST00000278064(uc001kxx.4)

ENST00000369720(uc001kxy.1) ENST00000369719(uc001kxz.3) ENST00000357060(uc001kxw.3)

ENST00000428666(uc009xxq.3)

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Additional cDNA sequence:

AK026597.1 AK093325.1 AK295018.1 AL136901.1 AL833836.1 BC036647.2 BC071565.1

9 DOTS entries:

DT.108069 DT.99941151 DT.75189594 DT.97833844 DT.91994967 DT.95282853 DT.95366415 DT.95366416

DT.99951037

24/55 AceView cDNA sequences (see all 55):

AL833836 AX748056 AL136901 CB306422 AL040174 BU674528 AI696602 AK093325

CD358816 AW665251 AW513742 AA813813 CN479147 NM_025145 CB215249 AK026597

AW510393 AI016235 AW148631 CD104492 CA423527 AI798901 BC071565 AI870243

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for WDR96 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:
SP2:																							-
SP3:
SP4:
SP5:							-

ExUns:	22a	·	22b	^	23	^	24	^	25	^	26	^	27a	·	27b	^	28a	·	28b	^	29a	·	29b	^	30	^	31	^	32	^	33	^	34	^	35	^	36a	·	36b	^	37	^	38a	·	38b
SP1:			-																				-		-												-
SP2:
SP3:																							-														-
SP4:
SP5:

ECgene alternative splicing isoforms for WDR96

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WDR96 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAATGTG

About this image

WDR96 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See WDR96 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR96

SOURCE GeneReport for Unigene cluster: Hs.288927

SABiosciences Custom PCR Arrays for WDR96

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR96

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for WDR96 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Wdr96^{1 , 5}	WD repeat domain 96^{1, 5}	76.97(n)¹ 73.9(a)¹		19 (40.41 cM)⁵ 100048534¹ NM_027559.2¹ NP_081835.2¹ 47737561⁵
chicken (Gallus gallus)	Aves	WDR96¹	WD repeat domain 96	58.8(n) 46.93(a)		423879 XM_421745.3 XP_421745.3
lizard (Anolis carolinensis)	Reptilia	WDR96⁶	--	49(a)	1 ↔ 1	3(41520247-41572965)
zebrafish (Danio rerio)	Actinopterygii	BM777651.1²	--	70.03(n)		BM777651.1
fruit fly (Drosophila melanogaster)	Insecta	CG17687⁶	--	16(a)	1 ↔ 1	3L(13342265-13348040)

ENSEMBL Gene Tree for WDR96 (if available)
TreeFam Gene Tree for WDR96 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112749115^1,2	C	--	105889249(+)	`GTCAAGATGG TCTC/-GATCT`	1	--	ds500¹		1		CSA	2
rs201013681^1,2		--	105889251(+)	`CAAGA-/TGGTCTCC`	1	--	ds500¹		0	--	--	--	--
rs11191929^1,2	C,F,H	--	105889334(+)	`AAATAT/AGTTGT`	1	--	ds500¹		24		NS EA NA WA	2902
rs41313473^1,2	C	--	105889661(+)	`CTTCAA/GGNNNN`	1	--	ut3¹		3		NA	124
rs138778238^1,2	C,F	--	105889912(+)	`ACAAGA/TGCAGG`	2	A	syn¹		2		NA EU	5823
rs185709522^1,2		--	105890135(+)	`AGAATC/TATACA`	1	--	int¹		0	--	--	--	--
rs149715495^1,2	C	--	105890162(+)	`GTAGC-/AAAAAG`	1	--	int¹		0	--	--	--	--
rs12260034^1,2	C,F	--	105890184(+)	`TGTATG/ATTTAC`	1	--	int¹		8		NA CSA WA EA	368
rs188911540^1,2		--	105890395(+)	`CAAATA/GCCACA`	1	--	int¹		0	--	--	--	--
rs181649335^1,2		--	105890425(+)	`GAGCTA/GAACAG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for WDR96 (105889646 - 105992120 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WDR96: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR96

DNA2.0 Custom Variant and Variant Library Synthesis for WDR96

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WDR96 for disorders About GeneDecksing

2 diseases for WDR96: About MalaCards

adhd alzheimer's disease

Export disorders for WDR96 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WDR96 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR96)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2, 3} Ota T.... Sugano S. (2004)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)¹ Lesch K.P....Jacob C. (2008)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)¹ Grupe A....Goate A. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)² Deloukas P.... Rogers J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)² Wiemann S.... Poustka A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 80217	HGNC: 26684	AceView: C10orf79	Ensembl:ENSG00000197748	euGenes: HUgn80217
ECgene: WDR96	H-InvDB: WDR96

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WDR96	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WDR96 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WDR96 gene:
Search GeneIP for patents involving WDR96

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR96
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR96

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for WDR96

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes WDR96 gene at Home site.

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WDR96 Gene

WD repeat domain 96

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WDR96 Gene

WD repeat domain 96

Aliasesfor WDR96 gene

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for WDR96 gene

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for WDR96 gene

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