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Aliases for WDR93 Gene

Aliases for WDR93 Gene

  • WD Repeat Domain 93 2 3 5

External Ids for WDR93 Gene

Previous GeneCards Identifiers for WDR93 Gene

  • GC15P088036
  • GC15P090234
  • GC15P066346

Summaries for WDR93 Gene

GeneCards Summary for WDR93 Gene

WDR93 (WD Repeat Domain 93) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on NAD(P)H.

Additional gene information for WDR93 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR93 Gene

Genomics for WDR93 Gene

GeneHancer (GH) Regulatory Elements for WDR93 Gene

Promoters and enhancers for WDR93 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I089689 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 566.6 +0.5 516 1.6 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 YY1 WDR93 PEX11A TICRR
GH15I089692 Promoter 0.5 EPDnew 550.8 +2.4 2408 0.1 PEX11A WDR93 GC15P089694
GH15I089892 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 13.6 +203.8 203822 2.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 AP3S2 POLG ENSG00000259314 LOC100631255 NIFKP5 FANCI ENSG00000259212 RPL36AP43 KIF7 ARPIN
GH15I089749 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.3 +61.1 61070 2.6 HDGF PKNOX1 CLOCK ATF1 ARID4B NEUROD1 SIN3A ZBTB7B ZNF48 POLR2B MESP1 MRPL15P1 POLG LOC100631255 ENSG00000259314 WDR93 PEX11A FANCI GC15M089695
GH15I090664 Enhancer 1.4 Ensembl ENCODE dbSUPER 13.5 +975.4 975365 2.1 HDGF PKNOX1 CLOCK ATF1 SMAD1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ENSG00000259314 ENSG00000259212 UNC45A WDR93 NIFKP5 FES MAN2A2 BLM RCCD1 ENSG00000200677
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR93 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR93 gene promoter:

Genomic Locations for WDR93 Gene

Genomic Locations for WDR93 Gene
chr15:89,690,085-89,743,790
(GRCh38/hg38)
Size:
53,706 bases
Orientation:
Plus strand
chr15:90,234,028-90,286,869
(GRCh37/hg19)

Genomic View for WDR93 Gene

Genes around WDR93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR93 Gene

Proteins for WDR93 Gene

  • Protein details for WDR93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2C0-WDR93_HUMAN
    Recommended name:
    WD repeat-containing protein 93
    Protein Accession:
    Q6P2C0
    Secondary Accessions:
    • Q8N7Y8
    • Q9NP89

    Protein attributes for WDR93 Gene

    Size:
    686 amino acids
    Molecular mass:
    77378 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR93 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR93 Gene

Post-translational modifications for WDR93 Gene

No Post-translational modifications

No data available for DME Specific Peptides for WDR93 Gene

Domains & Families for WDR93 Gene

Gene Families for WDR93 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR93 Gene

Suggested Antigen Peptide Sequences for WDR93 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR93: view

No data available for UniProtKB/Swiss-Prot for WDR93 Gene

Function for WDR93 Gene

Gene Ontology (GO) - Molecular Function for WDR93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016651 oxidoreductase activity, acting on NAD(P)H IEA --
genes like me logo Genes that share ontologies with WDR93: view

Phenotypes for WDR93 Gene

GenomeRNAi human phenotypes for WDR93:
genes like me logo Genes that share phenotypes with WDR93: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR93 Gene

Localization for WDR93 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR93 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR93 Gene

Pathways & Interactions for WDR93 Gene

SuperPathways for WDR93 Gene

No Data Available

Interacting Proteins for WDR93 Gene

Gene Ontology (GO) - Biological Process for WDR93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022900 electron transport chain IEA --
genes like me logo Genes that share ontologies with WDR93: view

No data available for Pathways by source and SIGNOR curated interactions for WDR93 Gene

Drugs & Compounds for WDR93 Gene

No Compound Related Data Available

Transcripts for WDR93 Gene

Unigene Clusters for WDR93 Gene

WD repeat domain 93:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR93 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5:

Relevant External Links for WDR93 Gene

GeneLoc Exon Structure for
WDR93
ECgene alternative splicing isoforms for
WDR93

Expression for WDR93 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR93 Gene

mRNA differential expression in normal tissues according to GTEx for WDR93 Gene

This gene is overexpressed in Testis (x17.5).

NURSA nuclear receptor signaling pathways regulating expression of WDR93 Gene:

WDR93

SOURCE GeneReport for Unigene cluster for WDR93 Gene:

Hs.177557

Evidence on tissue expression from TISSUES for WDR93 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with WDR93: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR93 Gene

Orthologs for WDR93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR93 33 34
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia WDR93 33 34
  • 83.63 (n)
mouse
(Mus musculus)
Mammalia Wdr93 33 16 34
  • 75.97 (n)
rat
(Rattus norvegicus)
Mammalia Wdr93 33
  • 75.7 (n)
cow
(Bos Taurus)
Mammalia WDR93 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR93 34
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR93 34
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR93 34
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr93 33
  • 52.99 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100149569 33
  • 46.32 (n)
WDR93 34
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToOne
Species where no ortholog for WDR93 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR93 Gene

ENSEMBL:
Gene Tree for WDR93 (if available)
TreeFam:
Gene Tree for WDR93 (if available)

Paralogs for WDR93 Gene

No data available for Paralogs for WDR93 Gene

Variants for WDR93 Gene

Sequence variations from dbSNP and Humsavar for WDR93 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs730882204 likely-pathogenic, Autistic spectrum disorder with isolated skills 89,702,026(+) T/C 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000127902 -- 89,696,267(+) A/C/G genic_upstream_transcript_variant, intron_variant
rs1000222397 -- 89,715,534(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000327881 -- 89,716,486(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000329520 -- 89,733,710(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR93 Gene

Variant ID Type Subtype PubMed ID
esv3344503 CNV insertion 20981092
esv3427628 CNV insertion 20981092
esv3637201 CNV loss 21293372
esv9488 CNV gain 19470904
nsv1046117 CNV gain 25217958
nsv1055055 CNV loss 25217958
nsv1660 CNV insertion 18451855
nsv570387 CNV loss 21841781
nsv570388 CNV loss 21841781
nsv952025 CNV deletion 24416366

Variation tolerance for WDR93 Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.59; 89.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR93 Gene

Human Gene Mutation Database (HGMD)
WDR93
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR93

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR93 Gene

Disorders for WDR93 Gene

Additional Disease Information for WDR93

No disorders were found for WDR93 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR93 Gene

Publications for WDR93 Gene

  1. A FAP46 mutant provides new insights into the function and assembly of the C1d complex of the ciliary central apparatus. (PMID: 22573824) Brown JM … Witman GB (Journal of cell science 2012) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families. (PMID: 25558065) Alazami AM … Alkuraya FS (Cell reports 2015) 3 58
  4. A genome-wide association study of sporadic ALS in a homogenous Irish population. (PMID: 18057069) Cronin S … Hardiman O (Human molecular genetics 2008) 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for WDR93 Gene

Sources for WDR93 Gene

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