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Aliases for WDR93 Gene

Aliases for WDR93 Gene

  • WD Repeat Domain 93 2 3 5

External Ids for WDR93 Gene

Previous GeneCards Identifiers for WDR93 Gene

  • GC15P088036
  • GC15P090234
  • GC15P066346

Summaries for WDR93 Gene

GeneCards Summary for WDR93 Gene

WDR93 (WD Repeat Domain 93) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity, acting on NAD(P)H.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR93 Gene

Genomics for WDR93 Gene

Regulatory Elements for WDR93 Gene

Enhancers for WDR93 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F089690 0.9 ENCODE 16.6 +0.7 672 1.3 PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 WDR93 PEX11A
GH15F089664 1 Ensembl ENCODE 11.8 -24.4 -24356 2.3 SUZ12 ZIC2 GLIS2 ZBTB48 POLR2A EED ZNF143 PRDM10 ETV6 CREM WDR93 RPL36AP43 PEX11A MESP1 TICRR KIF7 PLIN1
GH15F089662 1.1 Ensembl ENCODE 11.8 -26.9 -26862 1.8 ETV1 RAD21 GABPA YY1 ZNF83 POLR2A ZNF341 PBX2 ZBTB33 RPL36AP43 PEX11A WDR93 MESP1 TICRR ENSG00000228998 KIF7 PLIN1
GH15F089728 0.4 ENCODE 11.6 +38.4 38368 0.6 ZNF263 MESP1 WDR93 PEX11A RPL36AP43 PLIN1 GC15M089695
GH15F089749 1.1 ENCODE 10.3 +61.1 61071 2.6 HDGF ATF1 PKNOX1 MLX CREB3L1 ARID4B SIN3A ZNF2 ZNF48 GLIS2 MESP1 WDR93 PEX11A FANCI GC15M089695
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WDR93 on UCSC Golden Path with GeneCards custom track

Promoters for WDR93 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000128317 416 1799 PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for WDR93 Gene

Chromosome:
15
Start:
89,690,085 bp from pter
End:
89,743,790 bp from pter
Size:
53,706 bases
Orientation:
Plus strand

Genomic View for WDR93 Gene

Genes around WDR93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR93 Gene

Proteins for WDR93 Gene

  • Protein details for WDR93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2C0-WDR93_HUMAN
    Recommended name:
    WD repeat-containing protein 93
    Protein Accession:
    Q6P2C0
    Secondary Accessions:
    • Q8N7Y8
    • Q9NP89

    Protein attributes for WDR93 Gene

    Size:
    686 amino acids
    Molecular mass:
    77378 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR93 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR93 Gene

Post-translational modifications for WDR93 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR93 Gene

Domains & Families for WDR93 Gene

Gene Families for WDR93 Gene

Protein Domains for WDR93 Gene

Suggested Antigen Peptide Sequences for WDR93 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P2C0

UniProtKB/Swiss-Prot:

WDR93_HUMAN :
  • Contains 1 WD repeat.
Similarity:
  • Contains 1 WD repeat.
genes like me logo Genes that share domains with WDR93: view

Function for WDR93 Gene

Gene Ontology (GO) - Molecular Function for WDR93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity IBA --
GO:0016651 oxidoreductase activity, acting on NAD(P)H IEA --
genes like me logo Genes that share ontologies with WDR93: view

Phenotypes for WDR93 Gene

GenomeRNAi human phenotypes for WDR93:
genes like me logo Genes that share phenotypes with WDR93: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR93 Gene

Localization for WDR93 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR93 Gene COMPARTMENTS Subcellular localization image for WDR93 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WDR93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005747 mitochondrial respiratory chain complex I IBA --
genes like me logo Genes that share ontologies with WDR93: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR93 Gene

Pathways & Interactions for WDR93 Gene

SuperPathways for WDR93 Gene

No Data Available

Interacting Proteins for WDR93 Gene

Gene Ontology (GO) - Biological Process for WDR93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022900 electron transport chain IEA --
genes like me logo Genes that share ontologies with WDR93: view

No data available for Pathways by source and SIGNOR curated interactions for WDR93 Gene

Transcripts for WDR93 Gene

Unigene Clusters for WDR93 Gene

WD repeat domain 93:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR93 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5:

Relevant External Links for WDR93 Gene

GeneLoc Exon Structure for
WDR93
ECgene alternative splicing isoforms for
WDR93

Expression for WDR93 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR93 Gene

mRNA differential expression in normal tissues according to GTEx for WDR93 Gene

This gene is overexpressed in Testis (x17.5).

NURSA nuclear receptor signaling pathways regulating expression of WDR93 Gene:

WDR93

SOURCE GeneReport for Unigene cluster for WDR93 Gene:

Hs.177557
genes like me logo Genes that share expression patterns with WDR93: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for WDR93 Gene

Orthologs for WDR93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR93 34 35
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia WDR93 34 35
  • 83.63 (n)
mouse
(Mus musculus)
Mammalia Wdr93 34 16 35
  • 75.97 (n)
rat
(Rattus norvegicus)
Mammalia Wdr93 34
  • 75.7 (n)
cow
(Bos Taurus)
Mammalia WDR93 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR93 35
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR93 35
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR93 35
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr93 34
  • 52.99 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100149569 34
  • 46.32 (n)
WDR93 35
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToOne
Species where no ortholog for WDR93 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR93 Gene

ENSEMBL:
Gene Tree for WDR93 (if available)
TreeFam:
Gene Tree for WDR93 (if available)

Paralogs for WDR93 Gene

No data available for Paralogs for WDR93 Gene

Variants for WDR93 Gene

Sequence variations from dbSNP and Humsavar for WDR93 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs730882204 Likely pathogenic 89,702,026(+) CCGTC(C/T)ACCCT intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs10152653 -- 89,723,825(+) TCATG(C/T)CGTAC intron-variant
rs10528128 -- 89,732,617(+) TGGCC(-/A)CACAC intron-variant
rs10636523 -- 89,712,379(+) TTCAC(-/TAAT)TAGTT intron-variant
rs11073884 -- 89,689,212(+) TTGCG(G/T)GGATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDR93 Gene

Variant ID Type Subtype PubMed ID
esv3344503 CNV insertion 20981092
esv3427628 CNV insertion 20981092
esv3637201 CNV loss 21293372
esv9488 CNV gain 19470904
nsv1046117 CNV gain 25217958
nsv1055055 CNV loss 25217958
nsv1660 CNV insertion 18451855
nsv570387 CNV loss 21841781
nsv570388 CNV loss 21841781
nsv952025 CNV deletion 24416366

Variation tolerance for WDR93 Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.59; 89.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR93 Gene

Human Gene Mutation Database (HGMD)
WDR93
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR93

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR93 Gene

Disorders for WDR93 Gene

Relevant External Links for WDR93

Genetic Association Database (GAD)
WDR93
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR93

No disorders were found for WDR93 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR93 Gene

Publications for WDR93 Gene

  1. A FAP46 mutant provides new insights into the function and assembly of the C1d complex of the ciliary central apparatus. (PMID: 22573824) Brown J.M. … Witman G.B. (J. Cell. Sci. 2012) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families. (PMID: 25558065) Alazami A.M. … Alkuraya F.S. (Cell Rep 2015) 3 64
  4. A genome-wide association study of sporadic ALS in a homogenous Irish population. (PMID: 18057069) Cronin S. … Hardiman O. (Hum. Mol. Genet. 2008) 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for WDR93 Gene

Sources for WDR93 Gene

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