WDR92 Gene
protein-coding GIFtS: 45
GCID: GC02M068350
|
|
WD repeat domain 92
| |
Aliases
for WDR92 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 921 2 | | Monad1 | | WD Repeat-Containing Protein Monad2 3 | | WD Repeat-Containing Protein 922 | | FLJ317411 | | LOC1161435 | | Monad1 | | MONAD5 |
Export aliases for WDR92 gene to outside databasesPrevious GC identifers: GC02M068205 GC02M068094 |
Summaries
for WDR92 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDR92:
This gene encodes a protein with two WD40 repeat domains thought to be involved in an apoptosis via activation ofcaspase-3. Multiple transcript variants encoding different isoforms have been found for this gene. (provided byRefSeq, Feb 2012)
UniProtKB/Swiss-Prot: WDR92_HUMAN, Q96MX6Function: Seems to act as a modulator of apoptosis
|
Genomic Views
for WDR92 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR92 gene promoter:
GR Nkx3-1 Nkx3-1 v4 C/EBPbeta p53 Nkx3-1 v1 NF-kappaB Nkx3-1 v2 Nkx3-1 v3 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR92
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR92 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p14 Ensembl cytogenetic band: 2p14 HGNC cytogenetic band: 2p14WDR92 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M068350: view genomic region
(about GC identifiers)
Start:
|
68,350,068 bp from pter |
End:
|
68,384,692 bp from pter |
Size:
|
34,625 bases |
Orientation:
|
minus strand |
|
Proteins
for WDR92 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR92_HUMAN, Q96MX6 (See
protein sequence)Recommended Name: WD repeat-containing protein 92 Size: 357 amino acids; 39740 Da
1 PDB 3D structure from  and Proteopedia  for WDR92:3I2N (3D)
Secondary accessions: Q96CR6Alternative splicing: 2 isoforms: Q96MX6-1 Q96MX6-2 Explore the universe of human proteins at neXtProt for WDR92: NX_Q96MX6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96MX6
WDR92 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001243405.1 NP_612467.1
ENSEMBL proteins: ENSP00000295121 ENSP00000410301 ENSP00000384518 ENSP00000386746
Human Recombinant Protein Products:
WDR92 Antibody Products:
Assay Products for WDR92: |
Protein
Domains /
Families
for WDR92 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR92 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96MX6ProtoNet protein and cluster: Q96MX6 UniProtKB/Swiss-Prot: WDR92_HUMAN, Q96MX6Similarity: Contains 6 WD repeats |
Function
for WDR92 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WDR92_HUMAN, Q96MX6Function: Seems to act as a modulator of apoptosis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR92 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR92 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR92 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035064 | methylated histone residue binding |
IDA | 16600877 |
WDR92 for ontologies About GeneDecksing
|
Pathways & Interactions
for WDR92 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR92
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for WDR92 (Q96MX62, 3 ENSP000002951214) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
WDR92 for ontologies About GeneDecksing
|
Drugs & Compounds
for WDR92 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR92
Search CenterWatch for drugs/clinical trials and news about WDR92
|
Transcripts
for WDR92 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR92 gene (2 alternative transcripts): NM_001256476.1 NM_138458.3 Unigene Cluster for WDR92: WD repeat domain 92 Hs.631877 [show with all ESTs]Unigene Representative Sequence: AL8341426 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000492039(uc002sed.1) ENST00000295121(uc002see.1) ENST00000457114
ENST00000406245 ENST00000409164(uc002sef.1 uc002seg.1) ENST00000468984
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR92 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR92 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR92 (NM_138458) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR92 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR92 |
Additional cDNA sequence: AK056303.1 AK058090.1 AL834142.1 AY541587.1 BC014022.2 BC020271.1 BC036904.1 BC066657.1 NR_046234.1 8 DOTS entries: DT.40195773 DT.40206172 DT.100735333 DT.453079 DT.40125810 DT.102833044 DT.103697 DT.40196285 24/430 AceView cDNA sequences (see all 430): AY183476 AI263100 AA019009 BX349081 AI619993 BM142471 CB160277 BU688593 AA279031 NM_173177 CK820228 AI435863 BU581314 BX340492 AA283054 AK058090 BM263178 BM786368 NM_006333 BC014022 AI866855 AA703412 BM129531 AL834142
GeneLoc Exon Structure
|
Expression
for WDR92 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR92 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGGGCATCT
About this image
See WDR92 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR92
SOURCE GeneReport for Unigene cluster: Hs.631877
UniProtKB/Swiss-Prot: WDR92_HUMAN, Q96MX6Tissue specificity: Widely expressed with the highest expression in testis
SABiosciences Custom PCR Arrays for WDR92
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR92
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR92 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR92 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR92 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR92 |
Orthologs
for WDR92 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WDR92 gene from 6/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Wdr921 , 5 |
WD repeat domain 921, 5 |
88.24(n)1
93.56(a)1 |
|
11 (9.75 cM)5
1037841 NM_178909.41 NP_849240.11
171821075 |
chicken
(Gallus gallus) |
Aves |
WDR921 |
WD repeat domain 92 |
79.7(n)
90.1(a) |
|
769534 NM_001079744.1 NP_001073212.1 |
lizard
(Anolis carolinensis) |
Reptilia |
WDR926 |
-- |
43(a) |
1 ↔ 1 |
1(126546387-126600869) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.164002 |
Xenopus laevis transcribed sequence with weak similarity to protein refNP_037361.1 (H.sapiens) apoptotic protease activating factor isoform a; apoptotic protease activating factor 1 [Homo sapiens] less |
78.66(n) |
|
CD301610.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BI428243.12 |
-- |
71.88(n) |
|
BI428243.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG143531 |
CG14353 |
58.97(n)
59.26(a) |
|
39997 NM_140768.2 NP_649025.1 |
ENSEMBL Gene Tree for WDR92 (if available)
TreeFam Gene Tree for WDR92 (if available) |
Paralogs
for WDR92 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR92 gene
- CIB12 CIB32 PPP3R22 CIB42 PPP3R12 CHP22 TESC2 CIB22
- CHP12
2 SIMAP similar genes for WDR92 using alignment to 2 protein entries: WDR92_HUMAN (see all proteins):DKFZp434B156 HZGJ
WDR92 for paralogs About GeneDecksing
|
Genomic Variants
for WDR92 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR92 (68350068 - 68384692 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WDR92: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR92 |
|
Disorders
/ Diseases
for WDR92 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR92 for disorders About GeneDecksing
OMIM gene information: 610729
OMIM disorders: --
1  disease for WDR92: About MalaCardsmalaria
Export disorders for WDR92 gene to outside databases
|
Publications
for WDR92 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR92 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with WDR92) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Monad, a WD40 repeat protein, promotes apoptosis induced by TNF- alpha. (PubMed id 16487927)1, 2, 3 Saeki M.... Kamisaki Y. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Structure and function of WD40 domain proteins. (PubMed id 21468892)2 Xu C. and Min J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- High-resolution mapping of the protein interaction ne twork for the human transcription machinery and affinity purification of RNA po lymerase II-associated complexes. (PubMed id 19450687)1 Cloutier P....Coulombe B. (2009)
|
External Searches for WDR92 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR92 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR92 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR92 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR92 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR92 gene:
Search GeneIP for patents involving WDR92
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR92 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR92 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR92 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR92 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR92 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR92 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR92 |
| |
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 | | | WDR92 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR92 |
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