Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR92 Gene

Aliases for WDR92 Gene

  • WD Repeat Domain 92 2 3
  • WD Repeat-Containing Protein Monad 3 4
  • Monad 3 6
  • WD Repeat-Containing Protein 92 3
  • LOC116143 6

External Ids for WDR92 Gene

Previous GeneCards Identifiers for WDR92 Gene

  • GC02M068205
  • GC02M068350
  • GC02M068094

Summaries for WDR92 Gene

Entrez Gene Summary for WDR92 Gene

  • This gene encodes a protein with two WD40 repeat domains thought to be involved in an apoptosis via activation of caspase-3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for WDR92 Gene

WDR92 (WD Repeat Domain 92) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is CHP1.

UniProtKB/Swiss-Prot for WDR92 Gene

  • Seems to act as a modulator of apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR92 Gene

Genomics for WDR92 Gene

Regulatory Elements for WDR92 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR92 Gene

Start:
68,122,936 bp from pter
End:
68,157,560 bp from pter
Size:
34,625 bases
Orientation:
Minus strand

Genomic View for WDR92 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR92 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR92 Gene

Proteins for WDR92 Gene

  • Protein details for WDR92 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MX6-WDR92_HUMAN
    Recommended name:
    WD repeat-containing protein 92
    Protein Accession:
    Q96MX6
    Secondary Accessions:
    • Q96CR6

    Protein attributes for WDR92 Gene

    Size:
    357 amino acids
    Molecular mass:
    39740 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for WDR92 Gene

    Alternative splice isoforms for WDR92 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR92 Gene

Proteomics data for WDR92 Gene at MOPED

Post-translational modifications for WDR92 Gene

  • Ubiquitination at Lys69 and Lys235
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR92 Gene

Antibody Products

No data available for DME Specific Peptides for WDR92 Gene

Domains for WDR92 Gene

Gene Families for WDR92 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR92 Gene

Suggested Antigen Peptide Sequences for WDR92 Gene

Graphical View of Domain Structure for InterPro Entry

Q96MX6

UniProtKB/Swiss-Prot:

WDR92_HUMAN :
  • Q96MX6
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR92: view

Function for WDR92 Gene

Molecular function for WDR92 Gene

UniProtKB/Swiss-Prot Function: Seems to act as a modulator of apoptosis.

Gene Ontology (GO) - Molecular Function for WDR92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18538670
GO:0035064 methylated histone binding IDA 16600877
genes like me logo Genes that share ontologies with WDR92: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR92

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WDR92 Gene

Localization for WDR92 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR92 Gene COMPARTMENTS Subcellular localization image for WDR92 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR92 Gene

Pathways for WDR92 Gene

genes like me logo Genes that share pathways with WDR92: view

Gene Ontology (GO) - Biological Process for WDR92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0034968 histone lysine methylation IDA 16600877
genes like me logo Genes that share ontologies with WDR92: view

Transcripts for WDR92 Gene

Unigene Clusters for WDR92 Gene

WD repeat domain 92:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR92

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR92 Gene

No ASD Table

Relevant External Links for WDR92 Gene

GeneLoc Exon Structure for
WDR92
ECgene alternative splicing isoforms for
WDR92

Expression for WDR92 Gene

mRNA expression in normal human tissues for WDR92 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR92 Gene

SOURCE GeneReport for Unigene cluster for WDR92 Gene Hs.631877

mRNA Expression by UniProt/SwissProt for WDR92 Gene

Q96MX6-WDR92_HUMAN
Tissue specificity: Widely expressed with the highest expression in testis.
genes like me logo Genes that share expressions with WDR92: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR92 Gene

Orthologs for WDR92 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR92 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR92 35
  • 99.81 (n)
  • 99.72 (a)
cow
(Bos Taurus)
Mammalia PPP3R1 36
  • 5 (a)
ManyToMany
WDR92 35
  • 92.06 (n)
  • 94.96 (a)
WDR92 36
  • 95 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 50 (a)
OneToMany
WDR92 35
  • 91.97 (n)
  • 96.36 (a)
mouse
(Mus musculus)
Mammalia Ppp3r1 36
  • 5 (a)
ManyToMany
Wdr92 35
  • 88.24 (n)
  • 93.56 (a)
Wdr92 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 5 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
ManyToMany
-- 36
  • 4 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Wdr92 35
  • 86.65 (n)
  • 93.28 (a)
chicken
(Gallus gallus)
Aves PPP3R1 36
  • 5 (a)
ManyToMany
WDR92 35
  • 79.7 (n)
  • 90.1 (a)
WDR92 36
  • 83 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.16400 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20053 35
wdr92 35
  • 76.69 (n)
  • 83.71 (a)
zebrafish
(Danio rerio)
Actinopterygii ppp3r1a 36
  • 5 (a)
ManyToMany
ppp3r1b 36
  • 5 (a)
ManyToMany
wdr92 35
  • 72.38 (n)
  • 83.71 (a)
wdr92 36
  • 83 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006359 35
  • 56.53 (n)
  • 57.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14353 35
  • 58.9 (n)
  • 59.09 (a)
CG14353 36
  • 55 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.876 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToMany
Species with no ortholog for WDR92:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR92 Gene

ENSEMBL:
Gene Tree for WDR92 (if available)
TreeFam:
Gene Tree for WDR92 (if available)

Paralogs for WDR92 Gene

Paralogs for WDR92 Gene

Selected SIMAP similar genes for WDR92 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WDR92: view

Variants for WDR92 Gene

Sequence variations from dbSNP and Humsavar for WDR92 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs720110 -- 68,147,022(-) GAAAC(A/G)TATCT intron-variant
rs720111 -- 68,147,077(-) TAGCA(A/C)TGCAG intron-variant
rs1054867 -- 68,134,364(-) CCTTG(C/T)CTAAA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1135547 -- 68,132,374(-) GATTT(A/G)TAGGG intron-variant
rs1562666 -- 68,141,833(+) CAAAA(A/G)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR92 Gene

Variant ID Type Subtype PubMed ID
nsv834251 CNV Loss 17160897

Relevant External Links for WDR92 Gene

HapMap Linkage Disequilibrium report
WDR92

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR92 Gene

Disorders for WDR92 Gene

No disorders were found for WDR92 Gene.

No data available for UniProtKB/Swiss-Prot for WDR92 Gene

Publications for WDR92 Gene

  1. Monad, a WD40 repeat protein, promotes apoptosis induced by TNF- alpha. (PMID: 16487927) Saeki M. … Kamisaki Y. (Biochem. Biophys. Res. Commun. 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PMID: 14676191) Brajenovic M. … Drewes G. (J. Biol. Chem. 2004) 3

Products for WDR92 Gene

  • Addgene plasmids for WDR92

Sources for WDR92 Gene

Back to Top

Content