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WDR92 Gene

protein-coding   GIFtS: 48
GCID: GC02M068350

WD Repeat Domain 92

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 921 2
WD Repeat-Containing Protein Monad2 3
monad2
WD Repeat-Containing Protein 922
LOC1161435
MONAD5

External Ids:    HGNC: 251761   Entrez Gene: 1161432   Ensembl: ENSG000002436677   OMIM: 6107295   UniProtKB: Q96MX63   

Export aliases for WDR92 gene to outside databases

Previous GC identifers: GC02M068205 GC02M068094


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR92 Gene:
This gene encodes a protein with two WD40 repeat domains thought to be involved in an apoptosis via activation of
caspase-3. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Feb 2012)

GeneCards Summary for WDR92 Gene:
WDR92 (WD repeat domain 92) is a protein-coding gene. GO annotations related to this gene include methylated histone residue binding. An important paralog of this gene is CIB1.

UniProtKB/Swiss-Prot: WDR92_HUMAN, Q96MX6
Function: Seems to act as a modulator of apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR92 gene promoter:
         GR   Nkx3-1   Nkx3-1 v4   C/EBPbeta   p53   Nkx3-1 v1   NF-kappaB   Nkx3-1 v2   Nkx3-1 v3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR92 promoter sequence
   Search Chromatin IP Primers for WDR92

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR92


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p14

WDR92 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR92 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M068350:  view genomic region     (about GC identifiers)

Start:
68,350,068 bp from pter      End:
68,384,692 bp from pter
Size:
34,625 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WDR92_HUMAN, Q96MX6 (See protein sequence)
Recommended Name: WD repeat-containing protein 92  
Size: 357 amino acids; 39740 Da
1 PDB 3D structure from and Proteopedia for WDR92:
3I2N (3D)    
Secondary accessions: Q96CR6
Alternative splicing: 2 isoforms:  Q96MX6-1   Q96MX6-2   

Explore the universe of human proteins at neXtProt for WDR92: NX_Q96MX6

Explore proteomics data for WDR92 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys69, Lys235
  • Modification sites at PhosphoSitePlus

  • See WDR92 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243405.1  NP_612467.1  

    ENSEMBL proteins: 
     ENSP00000295121   ENSP00000410301   ENSP00000384518   ENSP00000386746  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96MX6

    ProtoNet protein and cluster: Q96MX6

    UniProtKB/Swiss-Prot: WDR92_HUMAN, Q96MX6
    Similarity: Contains 6 WD repeats


    Find genes that share domains with WDR92           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR92_HUMAN, Q96MX6
    Function: Seems to act as a modulator of apoptosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18538670
    GO:0035064methylated histone residue binding IDA16600877
         
    Find genes that share ontologies with WDR92           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WDR92 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    2Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Activation of BAD and translocation to mitochondria0.00
    Intrinsic Pathway for Apoptosis0.68
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    4PI-3K cascade
    Fc epsilon receptor (FCERI) signaling0.64
    5Ca-dependent events
    Opioid Signalling0.54




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR92
    Interactions:

        Search GeneGlobe Interaction Network for WDR92

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for WDR92 (Q96MX61, 2, 3 ENSP000002951214) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPAP3Q9H6T31, 2, 3, ENSP000000053864EBI-2434101,EBI-356928 MINT-6551118 MINT-6551132 MINT-6551090 MINT-6551101 I2D: score=1 STRING: ENSP00000005386
    PARD6AQ9NPB63, ENSP000002192554I2D: score=2 STRING: ENSP00000219255
    PRPF8ENSP000003043504STRING: ENSP00000304350
    ECDENSP000004015664STRING: ENSP00000401566
    TSSC4ENSP000003310874STRING: ENSP00000331087
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0034968histone lysine methylation IDA16600877

    Find genes that share ontologies with WDR92           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for WDR92



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR92 gene (2 alternative transcripts): 
    NM_001256476.1  NM_138458.3  

    Unigene Cluster for WDR92:

    WD repeat domain 92
    Hs.631877  [show with all ESTs]
    Unigene Representative Sequence: AL834142
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492039(uc002sed.1) ENST00000295121(uc002see.1) ENST00000457114
    ENST00000406245 ENST00000409164(uc002sef.1 uc002seg.1) ENST00000468984

    miRNA
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    hsa-miR-375 hsa-miR-1264 hsa-miR-216b hsa-miR-616* hsa-miR-371-5p hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidWDR92 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat WDR92

    Additional mRNA sequence: 

    AK056303.1 AK058090.1 AL834142.1 AY541587.1 BC014022.2 BC020271.1 BC036904.1 BC066657.1 
    NR_046234.1 

    8 DOTS entries:

    DT.40195773  DT.40206172  DT.100735333  DT.453079  DT.40125810  DT.102833044  DT.103697  DT.40196285 

    Selected AceView cDNA sequences (see all 430):

    AI263100 BU675203 BF223912 AA019009 BU581314 AI493088 AA954730 BP350152 
    CB160277 CB243698 NM_173177 BC009589 CK820229 BE857571 BM263178 BC014022 
    W01341 BX349081 BM786368 CK430831 BQ636280 AY183476 AA805413 AI017653 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR92 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGGCATCT
    WDR92 Expression
    About this image

    WDR92 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR92 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631877

    UniProtKB/Swiss-Prot: WDR92_HUMAN, Q96MX6
    Tissue specificity: Widely expressed with the highest expression in testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WDR92 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr921 , 5 WD repeat domain 921, 5 88.24(n)1
    93.56(a)1
      11 (9.75 cM)5
    1037841  NM_178909.41  NP_849240.11 
     171821075 
    chicken
    (Gallus gallus)
    Aves WDR921 WD repeat domain 92 79.7(n)
    90.1(a)
      769534  NM_001079744.1  NP_001073212.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    43(a)
    1 → many
    1(126546387-126637462)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.164002 Xenopus laevis transcribed sequence with weak similarity more 78.66(n)    CD301610.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI428243.12   -- 71.88(n)    BI428243.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG143531 CG14353 58.9(n)
    59.09(a)
      39997  NM_140768.2  NP_649025.1 


    ENSEMBL Gene Tree for WDR92 (if available)
    TreeFam Gene Tree for WDR92 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR92 gene
    CIB12  CIB32  PPP3R22  CIB42  PPP3R12  ENSG000002733982  CHP22  CIB22  
    CHP12  
    2 SIMAP similar genes for WDR92 using alignment to 2 protein entries:     WDR92_HUMAN (see all proteins):
    DKFZp434B156    HZGJ

    Find genes that share paralogs with WDR92           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR92 (see all 686)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1812585271,2
    --68214048(+) TGGGAA/GGCCAA 1 -- ds50010--------
    rs1382147381,2
    --68214146(+) CCAGAC/TATGGT 1 -- ds50010--------
    rs1853211771,2
    --68214179(+) TACTCA/GGGAGG 1 -- ds50010--------
    rs1905287151,2
    --68214201(+) GAATCA/GCTTGA 1 -- ds50010--------
    rs1144913821,2
    C,F--68214454(+) TCTAGA/GGACAG 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1832354041,2
    --68214497(+) TCACTA/GTCTTT 1 -- ds50010--------
    rs1869609081,2
    --68214612(+) TCAAGA/CGATTC 1 -- int10--------
    rs75996871,2
    C,F,H--68214911(+) ATTCAT/CAACAA 1 -- int131Minor allele frequency- C:0.26NS EA NA WA CSA 2906
    rs1921014361,2
    --68214924(+) CCTAAA/GTGGCC 1 -- int10--------
    rs729088361,2
    C,F--68214956(+) GTGGCC/GGTCAG 1 -- int12Minor allele frequency- G:0.17WA 120

    HapMap Linkage Disequilibrium report for WDR92 (68350068 - 68384692 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WDR92:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834251CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR92
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610729    OMIM disorders: --


    Find genes that share disorders with WDR92           About GenesLikeMe


    Export disorders for WDR92 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR92 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with WDR92)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Monad, a WD40 repeat protein, promotes apoptosis induced by TNF- alpha. (PubMed id 16487927)1, 2, 3 Saeki M.... Kamisaki Y. (Biochem. Biophys. Res. Commun. 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    4. Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA. (PubMed id 23844004)1 Saeki M....Kamisaki Y. (PLoS ONE 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    7. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (Hum. Genet. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Structure and function of WD40 domain proteins. (PubMed id 21468892)2 Xu C. and Min J. (Protein Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116143 HGNC: 25176 AceView: PPP3R1andC1DandLOC116143 Ensembl:ENSG00000243667 euGenes: HUgn116143
    ECgene: WDR92 H-InvDB: WDR92

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR92 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR92 gene:
    Search GeneIP for patents involving WDR92

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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