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Aliases for WDR92 Gene

Aliases for WDR92 Gene

  • WD Repeat Domain 92 2 3 5
  • WD Repeat-Containing Protein Monad 3 4
  • Testicular Secretory Protein Li 67 3
  • WD Repeat-Containing Protein 92 3
  • Monad 3

External Ids for WDR92 Gene

Previous GeneCards Identifiers for WDR92 Gene

  • GC02M068205
  • GC02M068350
  • GC02M068094

Summaries for WDR92 Gene

Entrez Gene Summary for WDR92 Gene

  • This gene encodes a protein with two WD40 repeat domains thought to be involved in an apoptosis via activation of caspase-3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for WDR92 Gene

WDR92 (WD Repeat Domain 92) is a Protein Coding gene. GO annotations related to this gene include methylated histone binding.

UniProtKB/Swiss-Prot for WDR92 Gene

  • Seems to act as a modulator of apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR92 Gene

Genomics for WDR92 Gene

Regulatory Elements for WDR92 Gene

Enhancers for WDR92 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F068192 1.8 VISTA Ensembl ENCODE 20.9 -37.0 -36981 4.7 ATF1 PKNOX1 ARNT ZNF766 ZNF143 FOS JUNB REST TBX21 ZNF518A WDR92 PPP3R1 PNO1 C1D ENSG00000273275 LOC102724389
GH02F068120 1.6 FANTOM5 Ensembl ENCODE 19 +36.4 36354 1.6 HDGF PKNOX1 ATF1 ARNT WRNIP1 SIN3A FEZF1 ELK1 GATA2 NCOA1 WDR92 PNO1 CNRIP1 LOC102724389 C1D LOC100287361 LOC105374789
GH02F068235 1.4 Ensembl ENCODE 18.4 -81.5 -81541 6.6 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF766 PPP3R1 WDR92 ETAA1 PNO1 APLF LOC102724389 ENSG00000273275
GH02F068248 1.1 ENCODE 18.5 -94.0 -94045 5.9 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 PPP3R1 WDR92 ETAA1 PNO1 LOC102724389
GH02F068189 1 Ensembl ENCODE 19.8 -33.3 -33340 2.6 BRD4 PKNOX1 JUN EED PRDM10 FOS MAFK ZNF197 ZNF680 ZNF362 PPP3R1 WDR92 PNO1 ENSG00000273275 LOC102724389
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR92 on UCSC Golden Path with GeneCards custom track

Promoters for WDR92 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001543229 -340 3001 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Location for WDR92 Gene

Chromosome:
2
Start:
68,122,936 bp from pter
End:
68,157,560 bp from pter
Size:
34,625 bases
Orientation:
Minus strand

Genomic View for WDR92 Gene

Genes around WDR92 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR92 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR92 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR92 Gene

Proteins for WDR92 Gene

  • Protein details for WDR92 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MX6-WDR92_HUMAN
    Recommended name:
    WD repeat-containing protein 92
    Protein Accession:
    Q96MX6
    Secondary Accessions:
    • Q96CR6

    Protein attributes for WDR92 Gene

    Size:
    357 amino acids
    Molecular mass:
    39740 Da
    Quaternary structure:
    • Interacts with PIH1D1.

    Three dimensional structures from OCA and Proteopedia for WDR92 Gene

    Alternative splice isoforms for WDR92 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR92 Gene

Post-translational modifications for WDR92 Gene

  • Ubiquitination at Lys 69 and Lys 235
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR92 Gene

No data available for DME Specific Peptides for WDR92 Gene

Domains & Families for WDR92 Gene

Gene Families for WDR92 Gene

Protein Domains for WDR92 Gene

Suggested Antigen Peptide Sequences for WDR92 Gene

Graphical View of Domain Structure for InterPro Entry

Q96MX6

UniProtKB/Swiss-Prot:

WDR92_HUMAN :
  • Contains 6 WD repeats.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR92: view

Function for WDR92 Gene

Molecular function for WDR92 Gene

UniProtKB/Swiss-Prot Function:
Seems to act as a modulator of apoptosis.

Gene Ontology (GO) - Molecular Function for WDR92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18538670
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with WDR92: view
genes like me logo Genes that share phenotypes with WDR92: view

Animal Model Products

miRNA for WDR92 Gene

miRTarBase miRNAs that target WDR92

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WDR92

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR92 Gene

Localization for WDR92 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR92 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR92 Gene

Pathways & Interactions for WDR92 Gene

SuperPathways for WDR92 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with WDR92: view

No data available for Pathways by source and SIGNOR curated interactions for WDR92 Gene

Transcripts for WDR92 Gene

Unigene Clusters for WDR92 Gene

WD repeat domain 92:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WDR92

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR92 Gene

No ASD Table

Relevant External Links for WDR92 Gene

GeneLoc Exon Structure for
WDR92
ECgene alternative splicing isoforms for
WDR92

Expression for WDR92 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR92 Gene

Protein differential expression in normal tissues from HIPED for WDR92 Gene

This gene is overexpressed in Breast (28.7) and Brain (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR92 Gene



Protein tissue co-expression partners for WDR92 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR92 Gene:

WDR92

SOURCE GeneReport for Unigene cluster for WDR92 Gene:

Hs.631877

mRNA Expression by UniProt/SwissProt for WDR92 Gene:

Q96MX6-WDR92_HUMAN
Tissue specificity: Widely expressed with the highest expression in testis.
genes like me logo Genes that share expression patterns with WDR92: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR92 Gene

Orthologs for WDR92 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR92 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR92 34
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia WDR92 34 35
  • 92.06 (n)
PPP3R1 35
  • 5 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia WDR92 34
  • 91.97 (n)
-- 35
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Wdr92 34 16
  • 88.24 (n)
Ppp3r1 35
  • 5 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Wdr92 34
  • 86.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
ManyToMany
-- 35
  • 4 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 5 (a)
ManyToMany
chicken
(Gallus gallus)
Aves WDR92 34 35
  • 79.7 (n)
PPP3R1 35
  • 5 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr92 34
  • 76.69 (n)
Str.20053 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16400 34
zebrafish
(Danio rerio)
Actinopterygii wdr92 34 35
  • 72.38 (n)
ppp3r1a 35
  • 5 (a)
ManyToMany
ppp3r1b 35
  • 5 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14353 34 35
  • 58.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006359 34
  • 56.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 67 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.876 34
Species where no ortholog for WDR92 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR92 Gene

ENSEMBL:
Gene Tree for WDR92 (if available)
TreeFam:
Gene Tree for WDR92 (if available)

Paralogs for WDR92 Gene

(2) SIMAP similar genes for WDR92 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WDR92: view

No data available for Paralogs for WDR92 Gene

Variants for WDR92 Gene

Sequence variations from dbSNP and Humsavar for WDR92 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10169081 -- 68,146,038(+) gagta(C/G)atcac intron-variant
rs1054867 -- 68,134,364(-) CCTTG(C/T)CTAAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10574149 -- 68,130,105(+) GTTTT(-/GA)GAGAG downstream-variant-500B
rs10606309 -- 68,156,124(+) AAAAA(-/AA)GCCAC intron-variant, upstream-variant-2KB
rs1060815 -- 68,158,503(+) TTAAC(C/T)TGAAA nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for WDR92 Gene

Variant ID Type Subtype PubMed ID
nsv834251 CNV loss 17160897
esv2762262 CNV loss 21179565

Variation tolerance for WDR92 Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR92 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR92

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR92 Gene

Disorders for WDR92 Gene

Relevant External Links for WDR92

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR92

No disorders were found for WDR92 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR92 Gene

Publications for WDR92 Gene

  1. Monad, a WD40 repeat protein, promotes apoptosis induced by TNF- alpha. (PMID: 16487927) Saeki M. … Kamisaki Y. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 64
  2. PIH1D1, a subunit of R2TP complex, inhibits doxorubicin-induced apoptosis. (PMID: 21078300) Inoue M. … Kamisaki Y. (Biochem. Biophys. Res. Commun. 2010) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for WDR92 Gene

Sources for WDR92 Gene

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