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Aliases for WDR91 Gene

Aliases for WDR91 Gene

  • WD Repeat Domain 91 2 3 5
  • HSPC049 3
  • SORF-1 3

External Ids for WDR91 Gene

Previous GeneCards Identifiers for WDR91 Gene

  • GC07M134521
  • GC07M134868
  • GC07M129171

Summaries for WDR91 Gene

GeneCards Summary for WDR91 Gene

WDR91 (WD Repeat Domain 91) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR91 Gene

Genomics for WDR91 Gene

Regulatory Elements for WDR91 Gene

Promoters for WDR91 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR91 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR91 Gene

Chromosome:
7
Start:
135,183,838 bp from pter
End:
135,211,564 bp from pter
Size:
27,727 bases
Orientation:
Minus strand

Genomic View for WDR91 Gene

Genes around WDR91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR91 Gene

Proteins for WDR91 Gene

  • Protein details for WDR91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1P6-WDR91_HUMAN
    Recommended name:
    WD repeat-containing protein 91
    Protein Accession:
    A4D1P6
    Secondary Accessions:
    • A6NK54
    • C9JMI4
    • Q6FI65
    • Q6MZQ1
    • Q6P4I1
    • Q96AE5
    • Q96G63
    • Q9H062
    • Q9H9B6
    • Q9NVG7
    • Q9NZY6

    Protein attributes for WDR91 Gene

    Size:
    747 amino acids
    Molecular mass:
    83344 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF29021.1; Type=Frameshift; Positions=136, 161, 166, 381, 392, 400, 405, 424, 442, 448, 458, 462, 501, 505, 508, 605, 626, 646, 712, 736; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR91 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR91 Gene

Proteomics data for WDR91 Gene at MOPED

Post-translational modifications for WDR91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR91 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR91 Gene

Domains & Families for WDR91 Gene

Gene Families for WDR91 Gene

Protein Domains for WDR91 Gene

Suggested Antigen Peptide Sequences for WDR91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4D1P6

UniProtKB/Swiss-Prot:

WDR91_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR91: view

Function for WDR91 Gene

genes like me logo Genes that share phenotypes with WDR91: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR91 Gene

Localization for WDR91 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR91 Gene COMPARTMENTS Subcellular localization image for WDR91 gene
Compartment Confidence
nucleus 3
cytosol 2
endosome 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR91 Gene

Pathways & Interactions for WDR91 Gene

SuperPathways for WDR91 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR91 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR91 Gene

Drugs & Compounds for WDR91 Gene

No Compound Related Data Available

Transcripts for WDR91 Gene

Unigene Clusters for WDR91 Gene

WD repeat domain 91:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR91 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: -
SP7: -
SP8:
SP9: -
SP10: - -

ExUns: 13a · 13b ^ 14 ^ 15
SP1:
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for WDR91 Gene

GeneLoc Exon Structure for
WDR91
ECgene alternative splicing isoforms for
WDR91

Expression for WDR91 Gene

mRNA expression in normal human tissues for WDR91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR91 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.2) and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR91 Gene



SOURCE GeneReport for Unigene cluster for WDR91 Gene Hs.459858

genes like me logo Genes that share expression patterns with WDR91: view

Protein tissue co-expression partners for WDR91 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR91 Gene

Orthologs for WDR91 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR91 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR91 35
  • 90.17 (n)
  • 93.61 (a)
WDR91 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR91 35
  • 89.71 (n)
  • 93.8 (a)
WDR91 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr91 35
  • 87.72 (n)
  • 92.47 (a)
Wdr91 16
Wdr91 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR91 35
  • 99.64 (n)
  • 99.6 (a)
WDR91 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr91 35
  • 87.41 (n)
  • 92.47 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR91 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR91 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR91 35
  • 75.3 (n)
  • 79.33 (a)
WDR91 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR91 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17335 35
wdr91 35
  • 69.37 (n)
  • 71.58 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18243 35
wdr91 35
  • 67.18 (n)
  • 68.1 (a)
wdr91 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6005 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK563.5 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.770 36
  • 36 (a)
OneToOne
Species with no ortholog for WDR91:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR91 Gene

ENSEMBL:
Gene Tree for WDR91 (if available)
TreeFam:
Gene Tree for WDR91 (if available)

Paralogs for WDR91 Gene

No data available for Paralogs for WDR91 Gene

Variants for WDR91 Gene

Sequence variations from dbSNP and Humsavar for WDR91 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs292592 - 135,204,389(+) CACGA(A/G)GTGAC nc-transcript-variant, reference, missense
rs8345 -- 135,185,449(+) tagcc(C/T)gTCTT nc-transcript-variant, utr-variant-3-prime
rs10457 -- 135,184,072(+) ACAGA(A/G)TCACT utr-variant-3-prime
rs11904 -- 135,184,202(+) AATAA(C/T)TATTT utr-variant-3-prime
rs292549 -- 135,184,296(+) CTTTG(A/G)TACCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WDR91 Gene

Variant ID Type Subtype PubMed ID
nsv527014 CNV Gain 19592680

Variation tolerance for WDR91 Gene

Residual Variation Intolerance Score: 5.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR91 Gene

HapMap Linkage Disequilibrium report
WDR91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR91 Gene

Disorders for WDR91 Gene

Relevant External Links for WDR91

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR91

No disorders were found for WDR91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR91 Gene

Publications for WDR91 Gene

  1. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  2. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. (PMID: 24550385) Abu-Odeh M. … Aqeilan R.I. (J. Biol. Chem. 2014) 3
  3. Novel Cul3 binding proteins function to remodel E3 ligase complexes. (PMID: 25011449) Wimuttisuk W. … Singer J.D. (BMC Cell Biol. 2014) 3
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for WDR91 Gene

Sources for WDR91 Gene

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