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Aliases for WDR91 Gene

Aliases for WDR91 Gene

  • WD Repeat Domain 91 2 3 5
  • WD Repeat-Containing Protein 91 3
  • HSPC049 3
  • SORF-1 3
  • SORF1 3

External Ids for WDR91 Gene

Previous GeneCards Identifiers for WDR91 Gene

  • GC07M134521
  • GC07M134868
  • GC07M129171

Summaries for WDR91 Gene

GeneCards Summary for WDR91 Gene

WDR91 (WD Repeat Domain 91) is a Protein Coding gene. Diseases associated with WDR91 include Usher Syndrome, Type 1B.

Additional gene information for WDR91 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR91 Gene

Genomics for WDR91 Gene

Regulatory Elements for WDR91 Gene

Enhancers for WDR91 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H135163 1.4 ENCODE dbSUPER 23.1 +43.1 43082 9.2 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 NUP205 ENSG00000273219 ENSG00000231794 WDR91 C7orf49 TMEM140 AGBL3 CNOT4 ENSG00000272941
GH07H135175 1.3 FANTOM5 ENCODE dbSUPER 23.1 +33.5 33516 4.9 MAFG CEBPB EP300 JUND ZNF316 SMARCC2 FOS NFE2 MLLT1 RUNX3 ENSG00000231794 WDR91 TMEM140 PIR40282 PIR51488
GH07H135253 1.2 FANTOM5 Ensembl ENCODE 22.4 -42.8 -42825 2 MCM3 JUND POLR2A JUN NFE2 ZIC2 NFE2L2 SPI1 WDR91 NUP205 STRA8 CALD1 ENSG00000231794 TMEM140 CNOT4 GC07P135285
GH07H135158 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +51.1 51073 4.6 HDGF PKNOX1 ATF1 ARNT ARID4B YY1 TCF12 ZNF766 CBX5 GATA2 C7orf49 WDR91 TMEM140 CNOT4 GC07M135162 PIR50393
GH07H135206 1.3 Ensembl ENCODE dbSUPER 12.4 +4.5 4487 1.6 PKNOX1 BACH1 BMI1 EBF1 BATF EED ATF7 ETV6 RUNX3 IKZF2 ENSG00000231794 WDR91 STRA8 C7orf49 TMEM140 AGBL3 MIR6509
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR91 on UCSC Golden Path with GeneCards custom track

Promoters for WDR91 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for WDR91 Gene

Genomic Locations for WDR91 Gene
27,727 bases
Minus strand

Genomic View for WDR91 Gene

Genes around WDR91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR91 Gene

Proteins for WDR91 Gene

  • Protein details for WDR91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 91
    Protein Accession:
    Secondary Accessions:
    • A6NK54
    • C9JMI4
    • Q6FI65
    • Q6MZQ1
    • Q6P4I1
    • Q96AE5
    • Q96G63
    • Q9H062
    • Q9H9B6
    • Q9NVG7
    • Q9NZY6

    Protein attributes for WDR91 Gene

    747 amino acids
    Molecular mass:
    83344 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF29021.1; Type=Frameshift; Positions=136, 161, 166, 381, 392, 400, 405, 424, 442, 448, 458, 462, 501, 505, 508, 605, 626, 646, 712, 736; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR91 Gene


neXtProt entry for WDR91 Gene

Post-translational modifications for WDR91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR91 Gene

No data available for DME Specific Peptides for WDR91 Gene

Domains & Families for WDR91 Gene

Gene Families for WDR91 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR91 Gene

Suggested Antigen Peptide Sequences for WDR91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR91: view

No data available for UniProtKB/Swiss-Prot for WDR91 Gene

Function for WDR91 Gene

Phenotypes From GWAS Catalog for WDR91 Gene

Gene Ontology (GO) - Molecular Function for WDR91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26783301
GO:0035014 phosphatidylinositol 3-kinase regulator activity IMP 26783301
genes like me logo Genes that share ontologies with WDR91: view
genes like me logo Genes that share phenotypes with WDR91: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR91 Gene

Localization for WDR91 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR91 gene
Compartment Confidence
nucleus 3
cytosol 2
endosome 2
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WDR91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 26783301
GO:0031313 extrinsic component of endosome membrane IDA 26783301
GO:0031901 early endosome membrane IDA 26783301
GO:0031902 late endosome membrane IDA 26783301
genes like me logo Genes that share ontologies with WDR91: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR91 Gene

Pathways & Interactions for WDR91 Gene

SuperPathways for WDR91 Gene

No Data Available

Interacting Proteins for WDR91 Gene

Gene Ontology (GO) - Biological Process for WDR91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 NOT ubiquitin-dependent protein catabolic process IMP 28404643
GO:0043551 regulation of phosphatidylinositol 3-kinase activity IMP 26783301
GO:0045022 early endosome to late endosome transport IMP 26783301
GO:1903362 regulation of cellular protein catabolic process IMP 27126989
genes like me logo Genes that share ontologies with WDR91: view

No data available for Pathways by source and SIGNOR curated interactions for WDR91 Gene

Drugs & Compounds for WDR91 Gene

No Compound Related Data Available

Transcripts for WDR91 Gene

Unigene Clusters for WDR91 Gene

WD repeat domain 91:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR91 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: -
SP7: -
SP9: -
SP10: - -

ExUns: 13a · 13b ^ 14 ^ 15
SP2: - -

Relevant External Links for WDR91 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR91 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR91 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.2) and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR91 Gene

Protein tissue co-expression partners for WDR91 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR91 Gene:


SOURCE GeneReport for Unigene cluster for WDR91 Gene:


Evidence on tissue expression from TISSUES for WDR91 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with WDR91: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR91 Gene

Orthologs for WDR91 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR91 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR91 33 34
  • 99.64 (n)
(Bos Taurus)
Mammalia WDR91 33 34
  • 90.17 (n)
(Canis familiaris)
Mammalia WDR91 33 34
  • 89.71 (n)
(Mus musculus)
Mammalia Wdr91 33 16 34
  • 87.72 (n)
(Rattus norvegicus)
Mammalia Wdr91 33
  • 87.41 (n)
(Monodelphis domestica)
Mammalia WDR91 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia WDR91 34
  • 69 (a)
(Gallus gallus)
Aves WDR91 33 34
  • 75.3 (n)
(Anolis carolinensis)
Reptilia WDR91 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr91 33
  • 69.37 (n)
Str.17335 33
(Danio rerio)
Actinopterygii wdr91 33 34
  • 67.18 (n)
Dr.18243 33
fruit fly
(Drosophila melanogaster)
Insecta CG6005 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea ZK563.5 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.770 34
  • 36 (a)
Species where no ortholog for WDR91 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR91 Gene

Gene Tree for WDR91 (if available)
Gene Tree for WDR91 (if available)

Paralogs for WDR91 Gene

No data available for Paralogs for WDR91 Gene

Variants for WDR91 Gene

Sequence variations from dbSNP and Humsavar for WDR91 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000006460 -- 135,191,697(+) AAGGG(C/T)TACAC intron-variant
rs1000209767 -- 135,188,466(+) GTGTT(C/T)TCATC intron-variant, nc-transcript-variant, reference, synonymous-codon
rs1000243621 -- 135,208,095(+) GGTGG(A/G)CCTCT intron-variant, upstream-variant-2KB
rs1000447724 -- 135,186,743(+) CCAGC(C/T)TGCCA intron-variant
rs1000453269 -- 135,196,619(+) CCCAG(G/T)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR91 Gene

Variant ID Type Subtype PubMed ID
nsv527014 CNV gain 19592680

Variation tolerance for WDR91 Gene

Residual Variation Intolerance Score: 5.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR91 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR91 Gene

Disorders for WDR91 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR91 Gene - From: DISEASES

Disorder Aliases PubMed IDs
usher syndrome, type 1b
  • usher syndrome type 1
- elite association - COSMIC cancer census association via MalaCards
Search WDR91 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDR91

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDR91: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR91 Gene

Publications for WDR91 Gene

  1. Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. (PMID: 26783301) Liu K … Yang C (The Journal of cell biology 2016) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 60
  5. The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. (PMID: 28404643) Liu X … Yang C (The Journal of cell biology 2017) 3 60

Products for WDR91 Gene

Sources for WDR91 Gene

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