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Aliases for WDR90 Gene

Aliases for WDR90 Gene

  • WD Repeat Domain 90 2 3 5
  • C16ORF15 3 4
  • C16orf16 3 4
  • C16orf17 3 4
  • C16orf18 3 4
  • C16orf19 3 4
  • Chromosome 16 Open Reading Frame 17 2
  • Chromosome 16 Open Reading Frame 15 2
  • Chromosome 16 Open Reading Frame 16 2
  • Chromosome 16 Open Reading Frame 19 2
  • Chromosome 16 Open Reading Frame 18 2
  • WD Repeat-Containing Protein 90 3
  • KIAA1924 4

External Ids for WDR90 Gene

Previous HGNC Symbols for WDR90 Gene

  • C16orf17
  • C16orf15
  • C16orf16
  • C16orf19
  • C16orf18

Previous GeneCards Identifiers for WDR90 Gene

  • GC16P000644
  • GC16P000645
  • GC16P000699
  • GC16P000624
  • GC16P000687
  • GC16P000688
  • GC16P000856
  • GC16P000884

Summaries for WDR90 Gene

GeneCards Summary for WDR90 Gene

WDR90 (WD Repeat Domain 90) is a Protein Coding gene. An important paralog of this gene is MAPKBP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR90 Gene

Genomics for WDR90 Gene

Regulatory Elements for WDR90 Gene

Enhancers for WDR90 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F000625 1 ENCODE 12.3 -22.5 -22486 1.9 SIN3A GLI4 ZNF2 GLIS2 FOS SMARCB1 SMARCA4 GLIS1 SP7 ZNF785 WFIKKN1 RAB40C WDR90 LOC105371038 ENSG00000261505 MPG ENSG00000260954 GC16M000614
GH16F000610 1.1 Ensembl ENCODE 12.2 -38.4 -38435 1.4 HDGF ARID4B SIN3A DMAP1 ZNF2 GLIS2 ZNF143 SP3 REST MBD2 WFIKKN1 RAB40C METTL26 NHLRC4 PIGQ WDR90 LOC105371038 PRR35 PIR61406 GC16P000603
GH16F000582 1.3 Ensembl ENCODE 7.6 -65.9 -65897 2.6 KLF17 ZNF2 GLIS2 ZNF366 EGR2 ZNF263 SP3 ZEB2 ZFP69B ZNF341 WFIKKN1 RAB40C WDR90 GC16P000587 ENSG00000282907
GH16F000640 0.5 ENCODE 6.5 -3.8 -3756 10.1 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 IFT140 ENSG00000262528 LOC105371038 ENSG00000268836 WFIKKN1 JMJD8 ENSG00000269482 WASH4P RHBDL1 TMEM204
GH16F000635 0.6 ENCODE 6.1 -12.2 -12239 4.1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 JMJD8 METTL26 WFIKKN1 ENSG00000260954 ENSG00000261505 ENSG00000226890 ENSG00000260051 HBZP1 PRSS29P IFT140
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WDR90 on UCSC Golden Path with GeneCards custom track

Promoters for WDR90 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502053 189 1801 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 PAF1 SP3 SP5 NFYC
ENSR00001798860 -1011 201 HDGF SIN3A ARID4B DMAP1 ZNF48 ZNF2 YY1 GLIS2 ZNF143 KLF7

Genomic Location for WDR90 Gene

Chromosome:
16
Start:
649,311 bp from pter
End:
667,833 bp from pter
Size:
18,523 bases
Orientation:
Plus strand

Genomic View for WDR90 Gene

Genes around WDR90 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR90 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR90 Gene

Proteins for WDR90 Gene

  • Protein details for WDR90 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KV7-WDR90_HUMAN
    Recommended name:
    WD repeat-containing protein 90
    Protein Accession:
    Q96KV7
    Secondary Accessions:
    • Q0VA87
    • Q0VA88
    • Q6P048
    • Q6ZMS1
    • Q6ZTH1
    • Q8N202
    • Q8N221
    • Q8NBB8
    • Q96PW4
    • Q96S18

    Protein attributes for WDR90 Gene

    Size:
    1748 amino acids
    Molecular mass:
    187437 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK61239.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB67817.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAC03575.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAC04225.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04225.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAD18654.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=EAW85775.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR90 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR90 Gene

Post-translational modifications for WDR90 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR90 Gene

Domains & Families for WDR90 Gene

Gene Families for WDR90 Gene

Suggested Antigen Peptide Sequences for WDR90 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KV7

UniProtKB/Swiss-Prot:

WDR90_HUMAN :
  • Contains 21 WD repeats.
Similarity:
  • Contains 21 WD repeats.
genes like me logo Genes that share domains with WDR90: view

Function for WDR90 Gene

Gene Ontology (GO) - Molecular Function for WDR90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WDR90: view
genes like me logo Genes that share phenotypes with WDR90: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR90 Gene

Localization for WDR90 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR90 Gene COMPARTMENTS Subcellular localization image for WDR90 gene
Compartment Confidence
nucleus 3
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR90 Gene

Pathways & Interactions for WDR90 Gene

SuperPathways for WDR90 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR90 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR90 Gene

Transcripts for WDR90 Gene

Unigene Clusters for WDR90 Gene

WD repeat domain 90:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR90 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34a · 34b · 34c ^ 35a · 35b ^ 36
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:

Relevant External Links for WDR90 Gene

GeneLoc Exon Structure for
WDR90
ECgene alternative splicing isoforms for
WDR90

Expression for WDR90 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR90 Gene

mRNA differential expression in normal tissues according to GTEx for WDR90 Gene

This gene is overexpressed in Testis (x4.2).

Protein differential expression in normal tissues from HIPED for WDR90 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR90 Gene



Protein tissue co-expression partners for WDR90 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR90 Gene:

WDR90

SOURCE GeneReport for Unigene cluster for WDR90 Gene:

Hs.511903
genes like me logo Genes that share expression patterns with WDR90: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WDR90 Gene

Orthologs for WDR90 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR90 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR90 34 35
  • 97.7 (n)
cow
(Bos Taurus)
Mammalia WDR90 34 35
  • 77.64 (n)
rat
(Rattus norvegicus)
Mammalia LOC102555298 34
  • 76.36 (n)
mouse
(Mus musculus)
Mammalia Wdr90 34 16 35
  • 75.62 (n)
dog
(Canis familiaris)
Mammalia WDR90 34 35
  • 75.15 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR90 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR90 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR90 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR90 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr90 34
  • 60.97 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr90 34 35
  • 55.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10064 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for WDR90 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR90 Gene

ENSEMBL:
Gene Tree for WDR90 (if available)
TreeFam:
Gene Tree for WDR90 (if available)

Paralogs for WDR90 Gene

Paralogs for WDR90 Gene

genes like me logo Genes that share paralogs with WDR90: view

Variants for WDR90 Gene

Sequence variations from dbSNP and Humsavar for WDR90 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1044662 -- 665,060(+) GCTTC(C/T)TCTCA intron-variant
rs1044663 -- 665,161(+) CAATC(A/G)GCGTG intron-variant
rs1047431 -- 648,380(+) CCCGT(C/T)TGACC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1057834 -- 662,758(+) TGGGC(A/G)TCGTG reference, missense
rs1057835 -- 662,867(+) TGGGC(A/G)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR90 Gene

Variant ID Type Subtype PubMed ID
dgv334n27 CNV loss 19166990
dgv4823n54 CNV loss 21841781
dgv4824n54 CNV loss 21841781
dgv4825n54 CNV loss 21841781
dgv4826n54 CNV loss 21841781
esv1011191 CNV deletion 20482838
esv2422427 CNV duplication 17116639
esv2750220 CNV deletion 23290073
esv2750221 CNV deletion 23290073
esv2750222 CNV deletion 23290073
esv2750223 CNV deletion 23290073
esv3637581 CNV loss 21293372
nsv103377 CNV deletion 16902084
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457310 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571016 CNV loss 21841781
nsv827479 CNV gain 20364138
nsv833114 CNV gain+loss 17160897
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for WDR90 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.39; 97.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR90 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR90

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR90 Gene

Disorders for WDR90 Gene

Relevant External Links for WDR90

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR90

No disorders were found for WDR90 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR90 Gene

Publications for WDR90 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for WDR90 Gene

Sources for WDR90 Gene

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