WDR90 Gene
protein-coding GIFtS: 41
GCID: GC16P000699
|
|
WD repeat domain 90(Previous names: chromosome 16 open reading frame 17, chromosome 16 open...)
(Previous symbols: C16orf17, C16orf15, C16orf16, C16orf19, C16orf18)
| |
Aliases
for WDR90 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 901 2 | | FLJ364831 | | C16orf151 2 3 | | Chromosome 16 Open Reading Frame 151 | | C16orf161 2 3 | | Chromosome 16 Open Reading Frame 161 | | C16orf171 2 3 | | Chromosome 16 Open Reading Frame 171 | | C16orf181 2 3 | | Chromosome 16 Open Reading Frame 181 | | C16orf191 2 3 | | Chromosome 16 Open Reading Frame 191 | | KIAA19241 3 | | WD Repeat-Containing Protein 902 |
Export aliases for WDR90 gene to outside databasesPrevious GC identifers: GC16P000644 GC16P000645 GC16P000624 |
Summaries
for WDR90 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDR90 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR90 gene promoter:
STAT1 STAT1beta AP-2alpha isoform 2 LCR-F1 STAT1alpha E47 HEN1 Ik-2 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR90
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR90 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3WDR90 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P000699: view genomic region
(about GC identifiers)
Start:
|
699,311 bp from pter |
End:
|
717,833 bp from pter |
Size:
|
18,523 bases |
Orientation:
|
plus strand |
|
Proteins
for WDR90 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR90_HUMAN, Q96KV7 (See
protein sequence)Recommended Name: WD repeat-containing protein 90 Size: 1748 amino acids; 187437 Da
Sequence caution: Sequence=AAK61239.1; Type=Erroneous gene model prediction; Sequence=BAB67817.1; Type=Miscellaneousdiscrepancy; Note=Intron retention; Sequence=BAC03575.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform.Aberrant splicing; Sequence=BAC04225.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAC04225.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=BAD18654.1;Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=EAW85775.1; Type=Erroneous gene modelprediction;
Secondary accessions: Q0VA87 Q0VA88 Q6P048 Q6ZMS1 Q6ZTH1 Q8N202 Q8N221 Q8NBB8 Q96PW4 Q96S18Alternative splicing: 5 isoforms: Q96KV7-1 Q96KV7-10 Q96KV7-3 Q96KV7-7 Q96KV7-5 (No experimental confirmation available. Ref.6 (AAI21186) sequence differs from that shown due to a frameshift in position 697)Explore the universe of human proteins at neXtProt for WDR90: NX_Q96KV7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96KV7
WDR90 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660337.3
ENSEMBL proteins: ENSP00000448122 ENSP00000293879 ENSP00000448603 ENSP00000447435 ENSP00000449576 ENSP00000322808 ENSP00000450308 ENSP00000447915
Human Recombinant Protein Products:
WDR90 Antibody Products:
Assay Products for WDR90: |
Protein
Domains /
Families
for WDR90 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR90 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q96KV7ProtoNet protein and cluster: Q96KV7 UniProtKB/Swiss-Prot: WDR90_HUMAN, Q96KV7Similarity: Contains 21 WD repeats |
Function
for WDR90 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR90 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR90
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR90 (NM_145294) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR90 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR90 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR90 |
1 GenomeRNAi human phenotype for WDR90:
|
Pathways & Interactions
for WDR90 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR90
|
Drugs & Compounds
for WDR90 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR90
Search CenterWatch for drugs/clinical trials and news about WDR90
|
Transcripts
for WDR90 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR90 gene (2 alternative transcripts): NM_145294.4 NM_153239.2 Unigene Cluster for WDR90: WD repeat domain 90 Hs.511903 [show with all ESTs]Unigene Representative Sequence: NM_14529418/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000552943(uc002cig.1 uc002cih.1 uc002cij.1) ENST00000549091(uc002cii.1)
ENST00000549648 ENST00000420061 ENST00000293879 ENST00000550593 ENST00000552648
ENST00000546516(uc002cik.1 uc002cim.1) ENST00000547407 ENST00000552728(uc002cil.1)
ENST00000548859 ENST00000552683 ENST00000548844 ENST00000550739 ENST00000549024(uc002cin.1)
ENST00000550902 ENST00000546923 ENST00000548603
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR90 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR90
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR90 (NM_145294) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR90 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR90 |
Additional cDNA sequence: AK092719.1 AK131510.1 BC062304.1 BC065836.1 BC121185.1 BC121186.1 12 DOTS entries: DT.97765830 DT.113593 DT.97827433 DT.75100565 DT.40311238 DT.120714617 DT.102836289 DT.70103140 DT.100677433 DT.121151992 DT.95343921 DT.97778329 24/136 AceView cDNA sequences (see all 136): BX492629 AA468572 AI797967 BX492640 BU070227 BM709834 BQ898698 CA432568 BU734188 CD518315 AW015205 AI634727 AI339873 AI493534 CA843007 AB067511 BM706508 BM547352 AA906707 AA448183 AA262616 BC065836 AX747688 NM_153239
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for WDR90 (see all 13) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31 | ^ | 32a | · | 32b | · | 32c | ^ | 33 | ^ | 34a | · | 34b | · | 34c | ^ | 35a | · | 35b | ^ | 36 |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR90
|
Expression
for WDR90 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR90 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCATTTATT
About this image
See WDR90 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR90
SOURCE GeneReport for Unigene cluster: Hs.511903
SABiosciences Custom PCR Arrays for WDR90
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR90
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR90 |
Orthologs
for WDR90 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for WDR90 gene from 3/16 species (see all 16) About this table
ENSEMBL Gene Tree for WDR90 (if available)
TreeFam Gene Tree for WDR90 (if available) |
Paralogs
for WDR90 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR90 gene
- EML52 EML32 MAPKBP12 WDR162 EML12 EML22 WDR622 EML62
- EML42
WDR90 for paralogs About GeneDecksing
|
Genomic Variants
for WDR90 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR90 (699311 - 717833 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for WDR90
11 CNVs: 49727 53069 29986 49728 3987 29982 5329 30732 29983 4914 29985 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR90 |
|
Disorders
/ Diseases
for WDR90 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR90 for disorders About GeneDecksing
1  disease for WDR90: About MalaCardsmalaria
Export disorders for WDR90 gene to outside databases
|
Publications
for WDR90 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR90 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR90) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T....Ohara O. (2001)
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2, 3 Daniels R.J....Higgs D.R. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for WDR90 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR90 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR90 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing WDR90 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR90 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR90 gene:
Search GeneIP for patents involving WDR90
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR90 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR90 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR90 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR90 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR90 | | OriGene 3'-UTR Clone for WDR90 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR90 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR90 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR90 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR90 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR90 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR90 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR90 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR90 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR90 |
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