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Aliases for WDR89 Gene

Aliases for WDR89 Gene

  • WD Repeat Domain 89 2 3 5
  • C14orf150 3 4
  • WD Repeat-Containing Protein 89 3
  • MSTP050 3

External Ids for WDR89 Gene

Previous HGNC Symbols for WDR89 Gene

  • C14orf150

Previous GeneCards Identifiers for WDR89 Gene

  • GC14M063135
  • GC14M064063
  • GC14M044230

Summaries for WDR89 Gene

GeneCards Summary for WDR89 Gene

WDR89 (WD Repeat Domain 89) is a Protein Coding gene.

Additional gene information for WDR89 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR89 Gene

Genomics for WDR89 Gene

Regulatory Elements for WDR89 Gene

Enhancers for WDR89 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H063852 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -213.7 -213663 6 SIN3A ZNF2 FOS RUNX3 SMARCB1 ZNF592 ZNF610 WT1 SP7 CTCF SYNE2 WDR89 PPP2R5E GC14P064073
GH14H064538 1.3 Ensembl ENCODE 11.1 -898.8 -898824 4 HDGF FOXA2 PKNOX1 ATF1 MLX ARID4B SIN3A BRCA1 YY1 GLIS2 LOC102723809 ZBTB25 ZBTB1 PPP1R36 ENSG00000214770 GCATP1 WDR89 PLEKHG3
GH14H063648 1.1 FANTOM5 Ensembl ENCODE 10.8 -8.5 -8473 3 PKNOX1 ZNF687 IKZF1 ZBTB33 IKZF2 WDR89 SYNE2 ENSG00000200693 GC14M063652 LOC105370532
GH14H063639 1.4 FANTOM5 ENCODE 7.5 +0.1 128 3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZBTB1 LOC102723809 SYNE2 WDR89 GCATP1 RNU6-1162P
GH14H064324 0.7 ENCODE 12.6 -683.1 -683055 1 ZNF146 JUN ZNF140 ZEB1 ZNF316 NFE2 PRDM10 MAFK NFE2L2 CEBPB ZBTB25 ENSG00000214770 WDR89 ZBTB1 GC14M064323 PIR41332
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR89 on UCSC Golden Path with GeneCards custom track

Promoters for WDR89 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069537 23 2601 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for WDR89 Gene

Chromosome:
14
Start:
63,597,039 bp from pter
End:
63,641,923 bp from pter
Size:
44,885 bases
Orientation:
Minus strand

Genomic View for WDR89 Gene

Genes around WDR89 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR89 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR89 Gene

Proteins for WDR89 Gene

  • Protein details for WDR89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FK6-WDR89_HUMAN
    Recommended name:
    WD repeat-containing protein 89
    Protein Accession:
    Q96FK6

    Protein attributes for WDR89 Gene

    Size:
    387 amino acids
    Molecular mass:
    43215 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDR89 Gene

Post-translational modifications for WDR89 Gene

  • Ubiquitination at Lys95
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR89 Gene

No data available for DME Specific Peptides for WDR89 Gene

Domains & Families for WDR89 Gene

Gene Families for WDR89 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR89 Gene

Suggested Antigen Peptide Sequences for WDR89 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR89: view

No data available for UniProtKB/Swiss-Prot for WDR89 Gene

Function for WDR89 Gene

Phenotypes From GWAS Catalog for WDR89 Gene

genes like me logo Genes that share phenotypes with WDR89: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDR89
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR89 Gene

Localization for WDR89 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR89 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR89 Gene

Pathways & Interactions for WDR89 Gene

SuperPathways for WDR89 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR89 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR89 Gene

Drugs & Compounds for WDR89 Gene

No Compound Related Data Available

Transcripts for WDR89 Gene

Unigene Clusters for WDR89 Gene

WD repeat domain 89:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDR89
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WDR89 Gene

No ASD Table

Relevant External Links for WDR89 Gene

GeneLoc Exon Structure for
WDR89
ECgene alternative splicing isoforms for
WDR89

Expression for WDR89 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR89 Gene

Protein differential expression in normal tissues from HIPED for WDR89 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.5), Lung (16.8), and CD4 Tcells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR89 Gene



Protein tissue co-expression partners for WDR89 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR89 Gene:

WDR89

SOURCE GeneReport for Unigene cluster for WDR89 Gene:

Hs.655666

Evidence on tissue expression from TISSUES for WDR89 Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with WDR89: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR89 Gene

Orthologs for WDR89 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR89 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR89 33 34
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia WDR89 33 34
  • 89.75 (n)
cow
(Bos Taurus)
Mammalia WDR89 33 34
  • 88.43 (n)
rat
(Rattus norvegicus)
Mammalia Wdr89 33
  • 82.04 (n)
mouse
(Mus musculus)
Mammalia Wdr89 33 16 34
  • 81.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR89 34
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR89 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR89 33 34
  • 67.1 (n)
lizard
(Anolis carolinensis)
Reptilia WDR89 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr89 33
  • 66.4 (n)
Str.16071 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17137 33
zebrafish
(Danio rerio)
Actinopterygii wdr89 33
  • 53.24 (n)
WDR89 34
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12134 33 34
  • 44.01 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005524 33
  • 42.26 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08449g 33
  • 47.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNL035C 33
  • 42.69 (n)
-- 34
  • 25 (a)
OneToOne
-- 36
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL218C 33
  • 40 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G47790 33
  • 48.27 (n)
rice
(Oryza sativa)
Liliopsida Os12g0294100 33
  • 47.67 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC63.06 33
  • 43.76 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02570 33
  • 41.93 (n)
Species where no ortholog for WDR89 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR89 Gene

ENSEMBL:
Gene Tree for WDR89 (if available)
TreeFam:
Gene Tree for WDR89 (if available)

Paralogs for WDR89 Gene

Pseudogenes.org Pseudogenes for WDR89 Gene

genes like me logo Genes that share paralogs with WDR89: view

No data available for Paralogs for WDR89 Gene

Variants for WDR89 Gene

Sequence variations from dbSNP and Humsavar for WDR89 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000007999 -- 63,632,699(+) ATAGC(A/T)GATGA intron-variant
rs1000015639 -- 63,620,333(+) AGATA(C/T)AGAAA intron-variant
rs1000046216 -- 63,598,330(+) AGCAT(A/G)ATACA utr-variant-3-prime
rs1000047457 -- 63,604,871(+) GTGGT(A/T)ACCCA intron-variant, upstream-variant-2KB
rs1000068339 -- 63,643,705(+) CAGGC(C/T)GGAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDR89 Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV gain 19592680
esv2677727 CNV deletion 23128226
esv3634726 CNV gain 21293372
esv3634734 CNV gain 21293372
esv3892555 CNV loss 25118596
nsv528691 CNV gain 19592680
nsv977475 CNV duplication 23825009

Variation tolerance for WDR89 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR89 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR89

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR89 Gene

Disorders for WDR89 Gene

Relevant External Links for WDR89

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR89

No disorders were found for WDR89 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR89 Gene

Publications for WDR89 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for WDR89 Gene

Sources for WDR89 Gene

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